locus-tag	class	description
F5989_RS00080	COG2801	Transposase and inactivated derivatives
F5989_RS00095	COG2226	methyltransferase
F5989_RS00100	COG1136	(ABC) transporter
F5989_RS00115	COG1309	transcriptional regulator
F5989_RS00155	COG1136	(ABC) transporter
F5989_RS00245	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F5989_RS00255	COG2884	Cell division ATP-binding protein ftsE
F5989_RS00260	COG2177	Part of the ABC transporter FtsEX involved in
F5989_RS00300	COG1122	ATPase activity
F5989_RS00310	COG1199	ATP-dependent helicase activity
F5989_RS00310	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F5989_RS00315	COG0436	Aminotransferase
F5989_RS00320	COG0017	Asparaginyl-tRNA synthetase
F5989_RS00330	COG0371	Dehydrogenase
F5989_RS00335	COG0251	oxidation-reduction process
F5989_RS00345	COG1660	Displays ATPase and GTPase activities
F5989_RS00355	COG1481	regulation of sporulation
F5989_RS00370	COG2226	methyltransferase
F5989_RS00385	COG0254	rRNA binding
F5989_RS00390	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
F5989_RS00395	COG0625	glutathione transferase activity
F5989_RS00400	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F5989_RS00405	COG0716	FMN binding
F5989_RS00420	COG0077	Prephenate dehydratase
F5989_RS00420	COG1605	Chorismate mutase
F5989_RS00425	COG0038	chloride channel
F5989_RS00430	COG0038	chloride channel
F5989_RS00440	COG0038	chloride channel
F5989_RS00450	COG0038	chloride channel
F5989_RS00460	COG0038	chloride channel
F5989_RS00470	COG0038	chloride channel
F5989_RS00475	COG0335	large ribosomal subunit rRNA binding
F5989_RS00485	COG2814	Major facilitator Superfamily
F5989_RS00510	COG0772	Belongs to the SEDS family
F5989_RS00525	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
F5989_RS00530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F5989_RS00535	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
F5989_RS00540	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F5989_RS00545	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F5989_RS00550	COG0560	Phosphoserine phosphatase
F5989_RS00555	COG0131	Imidazoleglycerol-phosphate dehydratase
F5989_RS00565	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F5989_RS00570	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F5989_RS00575	COG0107	imidazoleglycerol-phosphate synthase activity
F5989_RS00580	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F5989_RS00615	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F5989_RS00620	COG0732	type I restriction modification DNA specificity domain
F5989_RS00625	COG4974	Belongs to the 'phage' integrase family
F5989_RS00650	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F5989_RS00695	COG0148	phosphopyruvate hydratase activity
F5989_RS00705	COG1011	Hydrolase
F5989_RS00715	COG0322	excinuclease ABC activity
F5989_RS00725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F5989_RS00730	COG1573	uracil-dna glycosylase
F5989_RS00750	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F5989_RS00755	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
F5989_RS00760	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
F5989_RS00785	COG0813	purine-nucleoside phosphorylase activity
F5989_RS00800	COG0543	2 iron, 2 sulfur cluster binding
F5989_RS00805	COG0167	dihydroorotate dehydrogenase activity
F5989_RS00810	COG0284	orotidine-5'-phosphate decarboxylase activity
F5989_RS00815	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F5989_RS00820	COG1881	PFAM PEBP family protein
F5989_RS00825	COG2315	Protein conserved in bacteria
F5989_RS00835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F5989_RS00840	COG0765	amino acid transport
F5989_RS00845	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F5989_RS00855	COG0737	Belongs to the 5'-nucleotidase family
F5989_RS00860	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
F5989_RS00865	COG0187	DNA topoisomerase II activity
F5989_RS00890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F5989_RS00910	COG0539	negative regulation of cytoplasmic translation
F5989_RS00940	COG1131	(ABC) transporter
F5989_RS00945	COG1725	Transcriptional regulator
F5989_RS00955	COG0205	6-phosphofructokinase activity
F5989_RS00960	COG0469	pyruvate kinase activity
F5989_RS00965	COG2261	transglycosylase associated protein
F5989_RS00975	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F5989_RS00980	COG2213	PTS system mannitol-specific
F5989_RS00985	COG3711	transcriptional antiterminator
F5989_RS00990	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F5989_RS00995	COG0246	Mannitol dehydrogenase
F5989_RS01000	COG2824	Alkylphosphonate utilization operon protein PhnA
F5989_RS01005	COG0765	amino acid transport
F5989_RS01010	COG1126	abc transporter atp-binding protein
F5989_RS01015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F5989_RS01020	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F5989_RS01025	COG1115	amino acid carrier protein
F5989_RS01030	COG0210	DNA helicase
F5989_RS01035	COG2873	o-acetylhomoserine
F5989_RS01055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F5989_RS01080	COG2375	cellular response to nickel ion
F5989_RS01080	COG1132	(ABC) transporter
F5989_RS01085	COG1132	(ABC) transporter
F5989_RS01090	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
F5989_RS01145	COG0745	RESPONSE REGULATOR receiver
F5989_RS01150	COG2205	protein histidine kinase activity
F5989_RS01155	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F5989_RS01160	COG0196	riboflavin kinase activity
F5989_RS01165	COG1393	Belongs to the ArsC family
F5989_RS01170	COG4476	Belongs to the UPF0223 family
F5989_RS01175	COG0483	inositol monophosphate 1-phosphatase activity
F5989_RS01180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F5989_RS01180	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
F5989_RS01190	COG0573	inorganic phosphate transmembrane transporter activity
F5989_RS01195	COG0581	inorganic phosphate transmembrane transporter activity
F5989_RS01200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F5989_RS01205	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F5989_RS01210	COG0704	Plays a role in the regulation of phosphate uptake
F5989_RS01225	COG0745	RESPONSE REGULATOR receiver
F5989_RS01230	COG5002	protein histidine kinase activity
F5989_RS01235	COG0268	Binds directly to 16S ribosomal RNA
F5989_RS01240	COG1072	(Pantothenic acid kinase))
F5989_RS01245	COG2813	Specifically methylates the guanine in position
F5989_RS01250	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
F5989_RS01255	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F5989_RS01260	COG0295	cytidine deaminase activity
F5989_RS01265	COG1744	ABC transporter substrate-binding protein PnrA-like
F5989_RS01270	COG3845	ABC transporter
F5989_RS01275	COG4603	Belongs to the binding-protein-dependent transport system permease family
F5989_RS01280	COG1079	Belongs to the binding-protein-dependent transport system permease family
F5989_RS01295	COG0039	L-malate dehydrogenase activity
F5989_RS01305	COG3764	Sortase (surface protein transpeptidase)
F5989_RS01310	COG0346	lactoylglutathione lyase activity
F5989_RS01325	COG0561	phosphatase activity
F5989_RS01340	COG0406	alpha-ribazole phosphatase activity
F5989_RS01350	COG2723	6-phospho-beta-galactosidase activity
F5989_RS01355	COG0628	permease
F5989_RS01360	COG1063	alcohol dehydrogenase
F5989_RS01375	COG1174	glycine betaine transport
F5989_RS01380	COG1136	(ABC) transporter
F5989_RS01385	COG0577	efflux transmembrane transporter activity
F5989_RS01395	COG3976	FMN-binding domain protein
F5989_RS01395	COG1053	succinate dehydrogenase
F5989_RS01395	COG0431	NADPH-dependent FMN reductase
F5989_RS01410	COG1942	4-Oxalocrotonate Tautomerase
F5989_RS01415	COG1435	thymidine kinase activity
F5989_RS01420	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F5989_RS01425	COG2890	protein-(glutamine-N5) methyltransferase activity
F5989_RS01430	COG0009	L-threonylcarbamoyladenylate synthase
F5989_RS01435	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F5989_RS01450	COG1132	(ABC) transporter
F5989_RS01455	COG1132	(ABC) transporter
F5989_RS01460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F5989_RS01465	COG4684	Psort location CytoplasmicMembrane, score
F5989_RS01470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F5989_RS01480	COG2759	Belongs to the formate--tetrahydrofolate ligase family
F5989_RS01485	COG1247	-acetyltransferase
F5989_RS01505	COG1131	(ABC) transporter
F5989_RS01515	COG0519	Catalyzes the synthesis of GMP from XMP
F5989_RS01520	COG2188	Transcriptional regulator
F5989_RS01530	COG4175	Glycine betaine
F5989_RS01530	COG3448	diguanylate cyclase activity
F5989_RS01540	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
F5989_RS01545	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F5989_RS01575	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F5989_RS01580	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
F5989_RS01590	COG1104	cysteine desulfurase activity
F5989_RS01595	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F5989_RS01600	COG4116	CYTH
F5989_RS01615	COG2357	RelA SpoT domain protein
F5989_RS01620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F5989_RS01625	COG0564	pseudouridine synthase activity
F5989_RS01630	COG0280	phosphate acetyltransferase
F5989_RS01640	COG1131	(ABC) transporter
F5989_RS01645	COG4221	oxidoreductase activity
F5989_RS01650	COG1442	glycosyl transferase family 8
F5989_RS01655	COG0745	RESPONSE REGULATOR receiver
F5989_RS01660	COG5002	protein histidine kinase activity
F5989_RS01670	COG1131	(ABC) transporter
F5989_RS01675	COG4974	Belongs to the 'phage' integrase family
F5989_RS01680	COG2801	Transposase and inactivated derivatives
F5989_RS01705	COG3052	prosthetic group binding
F5989_RS01710	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
F5989_RS01715	COG0511	ligase activity, forming carbon-carbon bonds
F5989_RS01725	COG2851	Citrate transporter
F5989_RS01735	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
F5989_RS01740	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
F5989_RS01745	COG0642	Histidine kinase
F5989_RS01750	COG0745	RESPONSE REGULATOR receiver
F5989_RS01760	COG1136	(ABC) transporter
F5989_RS01765	COG5263	repeat protein
F5989_RS01765	COG0366	Alpha amylase catalytic
F5989_RS01770	COG0366	Alpha amylase catalytic
F5989_RS01770	COG5263	repeat protein
F5989_RS01775	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
F5989_RS01780	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F5989_RS01785	COG0758	DNA mediated transformation
F5989_RS01800	COG4607	ABC-type enterochelin transport system periplasmic component
F5989_RS01805	COG4604	ABC transporter, ATP-binding protein
F5989_RS01810	COG4605	iron ion homeostasis
F5989_RS01815	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F5989_RS01820	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F5989_RS01825	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
F5989_RS01840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F5989_RS01845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F5989_RS01855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F5989_RS01860	COG4932	domain protein
F5989_RS01890	COG1263	PTS System
F5989_RS01890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F5989_RS01890	COG2190	(PTS) system
F5989_RS01895	COG3711	transcriptional antiterminator
F5989_RS01900	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F5989_RS01905	COG1177	transmembrane transport
F5989_RS01910	COG1176	ABC-type spermidine putrescine transport system, permease component I
F5989_RS01915	COG3842	ATPase activity
F5989_RS01920	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F5989_RS01940	COG0302	gtp cyclohydrolase
F5989_RS01945	COG0285	dihydrofolate synthase activity
F5989_RS01950	COG0083	homoserine kinase activity
F5989_RS01960	COG0726	polysaccharide deacetylase
F5989_RS01965	COG1960	acyl-CoA dehydrogenase activity
F5989_RS01975	COG0222	ribosome binding
F5989_RS01980	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F5989_RS02000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F5989_RS02005	COG2040	homocysteine
F5989_RS02010	COG0833	amino acid
F5989_RS02015	COG0218	Necessary for normal cell division and for the maintenance of normal septation
F5989_RS02020	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F5989_RS02030	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F5989_RS02035	COG3201	nicotinamide mononucleotide transporter
F5989_RS02040	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
F5989_RS02045	COG3425	synthase
F5989_RS02060	COG1272	protein, Hemolysin III
F5989_RS02065	COG1304	FMN binding
F5989_RS02080	COG1126	abc transporter atp-binding protein
F5989_RS02085	COG0765	amino acid transport
F5989_RS02090	COG0765	amino acid transport
F5989_RS02095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F5989_RS02105	COG0583	DNA-binding transcription factor activity
F5989_RS02110	COG3759	membrane
F5989_RS02120	COG0745	RESPONSE REGULATOR receiver
F5989_RS02125	COG2357	RelA SpoT domain protein
F5989_RS02135	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
F5989_RS02140	COG1132	(ABC) transporter
F5989_RS02155	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F5989_RS02165	COG0602	queuosine metabolic process
F5989_RS02170	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F5989_RS02180	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F5989_RS02190	COG0366	Alpha amylase catalytic
F5989_RS02190	COG5263	repeat protein
F5989_RS02210	COG0488	(ABC) transporter
F5989_RS02215	COG0617	tRNA 3'-terminal CCA addition
F5989_RS02220	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F5989_RS02225	COG1307	EDD domain protein, DegV family
F5989_RS02260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F5989_RS02265	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
F5989_RS02270	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F5989_RS02275	COG1609	Transcriptional regulator
F5989_RS02280	COG0366	Alpha amylase catalytic
F5989_RS02285	COG3842	ATPase activity
F5989_RS02290	COG0366	Alpha amylase catalytic
F5989_RS02295	COG0395	ABC-type sugar transport system, permease component
F5989_RS02300	COG1175	transmembrane transport
F5989_RS02305	COG1653	transport
F5989_RS02310	COG3345	alpha-galactosidase
F5989_RS02315	COG2207	Transcriptional regulator
F5989_RS02325	COG2801	Transposase and inactivated derivatives
F5989_RS02330	COG0646	methionine synthase
F5989_RS02330	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
F5989_RS02335	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F5989_RS02340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F5989_RS02340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F5989_RS02340	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F5989_RS02345	COG1105	Belongs to the carbohydrate kinase PfkB family
F5989_RS02350	COG1349	DNA-binding transcription factor activity
F5989_RS02355	COG0492	ferredoxin-NADP+ reductase activity
F5989_RS02360	COG0336	Belongs to the RNA methyltransferase TrmD family
F5989_RS02365	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F5989_RS02370	COG1837	Belongs to the UPF0109 family
F5989_RS02375	COG0228	four-way junction DNA binding
F5989_RS02380	COG0577	efflux transmembrane transporter activity
F5989_RS02385	COG1136	(ABC) transporter
F5989_RS02395	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F5989_RS02400	COG0505	Belongs to the CarA family
F5989_RS02405	COG0540	Belongs to the ATCase OTCase family
F5989_RS02415	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
F5989_RS02425	COG0564	pseudouridine synthase activity
F5989_RS02430	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F5989_RS02435	COG0583	DNA-binding transcription factor activity
F5989_RS02440	COG2816	NAD+ diphosphatase activity
F5989_RS02450	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F5989_RS02460	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F5989_RS02480	COG0301	tRNA thio-modification
F5989_RS02485	COG1104	cysteine desulfurase activity
F5989_RS02495	COG0285	dihydrofolate synthase activity
F5989_RS02500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F5989_RS02505	COG0656	L-ascorbic acid biosynthetic process
F5989_RS02510	COG3942	CHAP domain
F5989_RS02525	COG0463	Glycosyl transferase, family 2
F5989_RS02535	COG1368	sulfuric ester hydrolase activity
F5989_RS02570	COG1091	dTDP-4-dehydrorhamnose reductase activity
F5989_RS02575	COG2151	metal-sulfur cluster biosynthetic enzyme
F5989_RS02580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F5989_RS02585	COG0358	DNA primase activity
F5989_RS02595	COG1970	mechanosensitive ion channel activity
F5989_RS02605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F5989_RS02615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F5989_RS02640	COG0556	nucleotide-excision repair
F5989_RS02655	COG1126	abc transporter atp-binding protein
F5989_RS02660	COG0488	(ABC) transporter
F5989_RS02670	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F5989_RS02730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F5989_RS02740	COG0077	Prephenate dehydratase
F5989_RS02745	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F5989_RS02750	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F5989_RS02755	COG3679	Belongs to the UPF0342 family
F5989_RS02760	COG0287	Prephenate dehydrogenase
F5989_RS02765	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F5989_RS02770	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F5989_RS02775	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F5989_RS02780	COG0710	3-dehydroquinate dehydratase activity
F5989_RS02785	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F5989_RS02790	COG1368	sulfuric ester hydrolase activity
F5989_RS02810	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F5989_RS02835	COG0366	Alpha amylase catalytic
F5989_RS02835	COG5263	repeat protein
F5989_RS02845	COG1914	H( )-stimulated, divalent metal cation uptake system
F5989_RS02850	COG4443	Transcriptional Coactivator p15 (PC4)
F5989_RS02865	COG0450	alkyl hydroperoxide reductase
F5989_RS02870	COG0826	peptidase U32
F5989_RS02895	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F5989_RS02900	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
F5989_RS02910	COG3091	SprT-like family
F5989_RS02915	COG2183	response to ionizing radiation
F5989_RS02930	COG0701	Predicted permease
F5989_RS02935	COG3689	TIGRFAM TIGR03943 family protein
F5989_RS02940	COG0477	Major facilitator Superfamily
F5989_RS02945	COG0552	protein localization to endoplasmic reticulum
F5989_RS02950	COG0561	phosphatase activity
F5989_RS02955	COG0561	phosphatase activity
F5989_RS03010	COG0604	alcohol dehydrogenase
F5989_RS03025	COG0584	glycerophosphoryl diester phosphodiesterase
F5989_RS03050	COG1078	dGTPase activity
F5989_RS03060	COG2348	transferase activity, transferring amino-acyl groups
F5989_RS03070	COG0149	triose-phosphate isomerase activity
F5989_RS03075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F5989_RS03080	COG0772	Belongs to the SEDS family
F5989_RS03085	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F5989_RS03105	COG3859	Proton-coupled thiamine transporter YuaJ
F5989_RS03120	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F5989_RS03130	COG0588	phosphoglycerate mutase activity
F5989_RS03135	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F5989_RS03140	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F5989_RS03145	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F5989_RS03150	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F5989_RS03170	COG2195	Cleaves the N-terminal amino acid of tripeptides
F5989_RS03210	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
F5989_RS03225	COG0656	L-ascorbic acid biosynthetic process
F5989_RS03230	COG0656	L-ascorbic acid biosynthetic process
F5989_RS03235	COG0789	Transcriptional regulator
F5989_RS03240	COG1012	belongs to the aldehyde dehydrogenase family
F5989_RS03245	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F5989_RS03250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F5989_RS03260	COG0538	isocitrate dehydrogenase activity
F5989_RS03265	COG0372	Belongs to the citrate synthase family
F5989_RS03270	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F5989_RS03275	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F5989_RS03280	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F5989_RS03290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F5989_RS03295	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F5989_RS03300	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F5989_RS03305	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F5989_RS03345	COG1131	(ABC) transporter
F5989_RS03365	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F5989_RS03375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F5989_RS03380	COG4122	O-methyltransferase activity
F5989_RS03385	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F5989_RS03385	COG0131	Imidazoleglycerol-phosphate dehydratase
F5989_RS03410	COG1028	Short-chain dehydrogenase reductase Sdr
F5989_RS03410	COG0604	alcohol dehydrogenase
F5989_RS03410	COG3321	synthase
F5989_RS03415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F5989_RS03425	COG1187	pseudouridine synthase activity
F5989_RS03435	COG0363	glucosamine-6-phosphate deaminase activity
F5989_RS03445	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F5989_RS03470	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F5989_RS03485	COG2333	competence protein COMEC
F5989_RS03485	COG0658	competence protein
F5989_RS03490	COG1555	photosystem II stabilization
F5989_RS03490	COG1596	polysaccharide export
F5989_RS03495	COG0204	Acyl-transferase
F5989_RS03500	COG0726	polysaccharide deacetylase
F5989_RS03510	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
F5989_RS03545	COG0513	Belongs to the DEAD box helicase family
F5989_RS03550	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F5989_RS03550	COG3064	Membrane
F5989_RS03560	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
F5989_RS03580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F5989_RS03585	COG0385	Bile acid
F5989_RS03595	COG1181	Belongs to the D-alanine--D-alanine ligase family
F5989_RS03600	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F5989_RS03605	COG0768	penicillin binding
F5989_RS03610	COG0588	phosphoglycerate mutase activity
F5989_RS03625	COG0735	belongs to the Fur family
F5989_RS03640	COG2801	Transposase and inactivated derivatives
F5989_RS03645	COG0776	regulation of translation
F5989_RS03655	COG2755	lipolytic protein G-D-S-L family
F5989_RS03660	COG1307	EDD domain protein, DegV family
F5989_RS03665	COG0497	DNA recombination
F5989_RS03670	COG1438	arginine binding
F5989_RS03675	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
F5989_RS03685	COG1722	exodeoxyribonuclease VII activity
F5989_RS03690	COG1570	exodeoxyribonuclease VII activity
F5989_RS03695	COG3275	phosphorelay sensor kinase activity
F5989_RS03700	COG3279	Response regulator of the LytR AlgR family
F5989_RS03705	COG1380	Effector of murein hydrolase LrgA
F5989_RS03710	COG1346	cytolysis
F5989_RS03715	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F5989_RS03720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F5989_RS03740	COG1126	abc transporter atp-binding protein
F5989_RS03745	COG0765	amino acid transport
F5989_RS03750	COG4703	Protein of unknown function (DUF1797)
F5989_RS03755	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F5989_RS03760	COG0542	response to heat
F5989_RS03775	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F5989_RS03780	COG3599	regulation of cell shape
F5989_RS03785	COG2302	S4 RNA-binding domain
F5989_RS03795	COG1799	cell septum assembly
F5989_RS03800	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F5989_RS03810	COG0849	cell division
F5989_RS03820	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F5989_RS03825	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F5989_RS03835	COG1217	gtp-binding protein TYPA
F5989_RS03845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F5989_RS03850	COG1940	carbohydrate kinase activity
F5989_RS03860	COG0783	Belongs to the Dps family
F5989_RS03870	COG0159	tryptophan synthase activity
F5989_RS03875	COG0133	tryptophan synthase activity
F5989_RS03880	COG0135	phosphoribosylanthranilate isomerase activity
F5989_RS03885	COG0134	indole-3-glycerol-phosphate synthase activity
F5989_RS03890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F5989_RS03895	COG0512	Glutamine amidotransferase of anthranilate synthase
F5989_RS03900	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F5989_RS03920	COG3804	dihydrodipicolinate reductase
F5989_RS03930	COG1132	(ABC) transporter
F5989_RS03935	COG1132	(ABC) transporter
F5989_RS03945	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F5989_RS03950	COG4470	Protein conserved in bacteria
F5989_RS03955	COG0737	Belongs to the 5'-nucleotidase family
F5989_RS03960	COG3480	Lon protease (S16) C-terminal proteolytic domain
F5989_RS03965	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F5989_RS03970	COG0742	ribosomal rna small subunit methyltransferase
F5989_RS03975	COG4716	Myosin-crossreactive antigen
F5989_RS04030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F5989_RS04040	COG0561	phosphatase activity
F5989_RS04045	COG1349	DNA-binding transcription factor activity
F5989_RS04090	COG1040	competence protein
F5989_RS04095	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
F5989_RS04100	COG1739	Uncharacterized protein family UPF0029
F5989_RS04120	COG1882	Formate acetyltransferase
F5989_RS04125	COG1349	DNA-binding transcription factor activity
F5989_RS04130	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F5989_RS04135	COG1098	S1 RNA binding domain
F5989_RS04145	COG2197	response regulator
F5989_RS04150	COG4585	Histidine kinase
F5989_RS04170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F5989_RS04170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F5989_RS04175	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F5989_RS04180	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F5989_RS04185	COG1758	RNA polymerase activity
F5989_RS04190	COG0194	GDP metabolic process
F5989_RS04195	COG1418	mRNA catabolic process
F5989_RS04195	COG4372	Transposase
F5989_RS04200	COG1854	S-ribosylhomocysteine lyase activity
F5989_RS04210	COG0116	Belongs to the methyltransferase superfamily
F5989_RS04220	COG3599	regulation of cell shape
F5989_RS04225	COG4474	Belongs to the UPF0398 family
F5989_RS04230	COG3331	DNA recombination
F5989_RS04235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F5989_RS04240	COG3579	cysteine-type endopeptidase activity
F5989_RS04245	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F5989_RS04250	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
F5989_RS04255	COG0492	ferredoxin-NADP+ reductase activity
F5989_RS04265	COG1126	abc transporter atp-binding protein
F5989_RS04280	COG0513	Belongs to the DEAD box helicase family
F5989_RS04290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F5989_RS04295	COG0768	penicillin binding
F5989_RS04300	COG4839	cell division protein FtsL
F5989_RS04305	COG0275	rRNA processing
F5989_RS04315	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F5989_RS04320	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F5989_RS04330	COG4224	UPF0291 protein
F5989_RS04335	COG0751	glycine-tRNA ligase activity
F5989_RS04340	COG0752	glycyl-tRNA synthetase alpha subunit
F5989_RS04350	COG1673	EVE domain
F5989_RS04370	COG1924	4 iron, 4 sulfur cluster binding
F5989_RS04395	COG1131	(ABC) transporter
F5989_RS04405	COG0561	phosphatase activity
F5989_RS04415	COG2217	Heavy metal translocating P-type atpase
F5989_RS04430	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F5989_RS04435	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F5989_RS04445	COG2740	Nucleic-acid-binding protein implicated in transcription termination
F5989_RS04450	COG0195	Participates in both transcription termination and antitermination
F5989_RS04455	COG0779	Required for maturation of 30S ribosomal subunits
F5989_RS04465	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F5989_RS04475	COG4473	ABC transporter
F5989_RS04480	COG1131	(ABC) transporter
F5989_RS04485	COG0537	adenosine 5'-monophosphoramidase activity
F5989_RS04495	COG1316	TRANSCRIPTIONal
F5989_RS04500	COG0802	atpase or kinase
F5989_RS04505	COG2252	PERMEase
F5989_RS04515	COG0561	phosphatase activity
F5989_RS04530	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F5989_RS04535	COG1882	Formate acetyltransferase
F5989_RS04545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F5989_RS04560	COG2936	dipeptidyl-peptidase activity
F5989_RS04565	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F5989_RS04575	COG2081	HI0933 family
F5989_RS04595	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F5989_RS04600	COG0456	acetyltransferase
F5989_RS04605	COG1214	PFAM Peptidase M22, glycoprotease
F5989_RS04615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F5989_RS04620	COG0667	Aldo Keto reductase
F5989_RS04635	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F5989_RS04650	COG2226	methyltransferase
F5989_RS04670	COG5503	Protein of unknown function (DUF1447)
F5989_RS04680	COG3942	CHAP domain
F5989_RS04685	COG0493	'glutamate synthase
F5989_RS04690	COG0067	glutamate synthase
F5989_RS04690	COG0070	glutamate synthase
F5989_RS04690	COG0069	glutamate synthase activity
F5989_RS04695	COG0174	glutamine synthetase
F5989_RS04700	COG0789	Transcriptional regulator
F5989_RS04710	COG0126	phosphoglycerate kinase activity
F5989_RS04720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F5989_RS04725	COG0049	tRNA binding
F5989_RS04730	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F5989_RS04735	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F5989_RS04760	COG1162	GTPase activity
F5989_RS04780	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F5989_RS04815	COG0084	hydrolase, TatD family'
F5989_RS04820	COG0230	Belongs to the bacterial ribosomal protein bL34 family
F5989_RS04835	COG0706	membrane insertase activity
F5989_RS04840	COG0594	ribonuclease P activity
F5989_RS04845	COG0165	Argininosuccinate lyase
F5989_RS04850	COG0137	argininosuccinate synthase activity
F5989_RS04865	COG1827	regulation of RNA biosynthetic process
F5989_RS04870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F5989_RS04895	COG0756	dUTP diphosphatase activity
F5989_RS04900	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F5989_RS04905	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F5989_RS04910	COG0705	Rhomboid family
F5989_RS04910	COG0457	Tetratricopeptide repeat
F5989_RS04915	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F5989_RS04920	COG1473	amidohydrolase
F5989_RS04925	COG2171	N-acyltransferase activity
F5989_RS04945	COG3732	PTS system glucitol sorbitol-specific
F5989_RS04950	COG3730	PTS system glucitol sorbitol-specific
F5989_RS04960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F5989_RS04960	COG3711	transcriptional antiterminator
F5989_RS04970	COG0166	Belongs to the GPI family
F5989_RS04990	COG1234	tRNA 3'-trailer cleavage
F5989_RS05005	COG0343	queuine tRNA-ribosyltransferase activity
F5989_RS05015	COG1832	CoA-binding protein
F5989_RS05020	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F5989_RS05020	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F5989_RS05035	COG0583	DNA-binding transcription factor activity
F5989_RS05065	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F5989_RS05095	COG3711	transcriptional antiterminator
F5989_RS05095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F5989_RS05110	COG2274	protein secretion by the type I secretion system
F5989_RS05165	COG3623	hexulose-6-phosphate isomerase
F5989_RS05175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F5989_RS05190	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F5989_RS05195	COG1181	Belongs to the D-alanine--D-alanine ligase family
F5989_RS05195	COG2918	glutathione biosynthetic process
F5989_RS05205	COG2957	Belongs to the agmatine deiminase family
F5989_RS05210	COG0531	amino acid
F5989_RS05215	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F5989_RS05230	COG4608	Belongs to the ABC transporter superfamily
F5989_RS05235	COG0444	Belongs to the ABC transporter superfamily
F5989_RS05240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F5989_RS05245	COG0601	transmembrane transport
F5989_RS05250	COG4166	transmembrane transport
F5989_RS05265	COG0719	Fe-S assembly protein
F5989_RS05275	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F5989_RS05280	COG0719	Fe-S assembly protein
F5989_RS05290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F5989_RS05295	COG4862	establishment of competence for transformation
F5989_RS05300	COG1968	undecaprenyl-diphosphatase activity
F5989_RS05310	COG0765	amino acid transport
F5989_RS05315	COG1126	abc transporter atp-binding protein
F5989_RS05335	COG1309	transcriptional regulator
F5989_RS05345	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F5989_RS05350	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F5989_RS05355	COG0440	acetolactate synthase activity
F5989_RS05360	COG0028	Belongs to the TPP enzyme family
F5989_RS05400	COG0582	viral genome integration into host DNA
F5989_RS05465	COG1674	ftsk spoiiie
F5989_RS05515	COG0433	COG0433 Predicted ATPase
F5989_RS05525	COG3942	CHAP domain
F5989_RS05525	COG1388	LysM domain
F5989_RS05640	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
F5989_RS05645	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F5989_RS05655	COG0803	Belongs to the bacterial solute-binding protein 9 family
F5989_RS05670	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F5989_RS05675	COG0431	NADPH-dependent FMN reductase
F5989_RS05675	COG1053	succinate dehydrogenase
F5989_RS05675	COG3976	FMN-binding domain protein
F5989_RS05680	COG0431	NADPH-dependent FMN reductase
F5989_RS05680	COG1053	succinate dehydrogenase
F5989_RS05680	COG3976	FMN-binding domain protein
F5989_RS05690	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F5989_RS05715	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F5989_RS05720	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F5989_RS05725	COG1476	TRANSCRIPTIONal
F5989_RS05745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F5989_RS05765	COG5504	Zn-dependent protease
F5989_RS05770	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
F5989_RS05775	COG0215	cysteine-tRNA ligase activity
F5989_RS05780	COG1045	serine acetyltransferase
F5989_RS05790	COG1185	polyribonucleotide nucleotidyltransferase activity
F5989_RS05795	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F5989_RS05800	COG1012	belongs to the aldehyde dehydrogenase family
F5989_RS05800	COG1454	alcohol dehydrogenase
F5989_RS05810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F5989_RS05815	COG0242	peptide deformylase activity
F5989_RS05830	COG2140	Oxalate decarboxylase
F5989_RS05835	COG0679	Auxin Efflux Carrier
F5989_RS05840	COG0281	malic enzyme
F5989_RS05850	COG0583	DNA-binding transcription factor activity
F5989_RS05855	COG1309	transcriptional regulator
F5989_RS05860	COG0477	Major facilitator Superfamily
F5989_RS05865	COG1473	amidohydrolase
F5989_RS05870	COG0095	Lipoate-protein ligase
F5989_RS05885	COG0508	dehydrogenase complex catalyzes the overall conversion of
F5989_RS05885	COG0022	dehydrogenase e1 component
F5989_RS05890	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F5989_RS05895	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F5989_RS05900	COG1846	Transcriptional regulator
F5989_RS05905	COG2176	DNA-directed DNA polymerase activity
F5989_RS05910	COG0534	Mate efflux family protein
F5989_RS05915	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F5989_RS05935	COG3684	Belongs to the aldolase LacD family
F5989_RS05940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F5989_RS05940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F5989_RS05940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F5989_RS05945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F5989_RS05945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F5989_RS05945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F5989_RS05950	COG1105	Belongs to the carbohydrate kinase PfkB family
F5989_RS05965	COG0191	fructose-bisphosphate aldolase activity
F5989_RS05975	COG0504	CTP synthase activity
F5989_RS05980	COG3343	RNA polymerase activity
F5989_RS05985	COG0544	peptidyl-prolyl cis-trans isomerase activity
F5989_RS05995	COG0668	transmembrane transport
F5989_RS06000	COG4475	Protein of unknown function (DUF436)
F5989_RS06005	COG4720	Psort location CytoplasmicMembrane, score
F5989_RS06010	COG0351	phosphomethylpyrimidine kinase
F5989_RS06015	COG0101	tRNA pseudouridine synthase activity
F5989_RS06020	COG0484	heat shock protein binding
F5989_RS06025	COG0443	Heat shock 70 kDa protein
F5989_RS06030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F5989_RS06035	COG1420	regulation of RNA biosynthetic process
F5989_RS06040	COG1621	beta-fructofuranosidase activity
F5989_RS06045	COG3583	domain protein
F5989_RS06045	COG1621	beta-fructofuranosidase activity
F5989_RS06045	COG5492	domain, Protein
F5989_RS06050	COG1705	Flagellar rod assembly protein muramidase FlgJ
F5989_RS06065	COG2848	UPF0210 protein
F5989_RS06070	COG3830	Belongs to the UPF0237 family
F5989_RS06075	COG0534	Mate efflux family protein
F5989_RS06100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F5989_RS06105	COG2255	four-way junction helicase activity
F5989_RS06125	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F5989_RS06145	COG1794	racemase activity, acting on amino acids and derivatives
F5989_RS06160	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F5989_RS06170	COG0151	Belongs to the GarS family
F5989_RS06175	COG0457	Tetratricopeptide repeat
F5989_RS06205	COG0138	bifunctional purine biosynthesis protein purh
F5989_RS06215	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F5989_RS06220	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F5989_RS06225	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F5989_RS06235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F5989_RS06240	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F5989_RS06245	COG2274	protein secretion by the type I secretion system
F5989_RS06250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F5989_RS06255	COG0416	fatty acid biosynthetic process
F5989_RS06260	COG1381	Involved in DNA repair and RecF pathway recombination
F5989_RS06265	COG0436	Aminotransferase
F5989_RS06270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F5989_RS06275	COG3942	CHAP domain
F5989_RS06285	COG1792	Involved in formation and maintenance of cell shape
F5989_RS06400	COG0531	amino acid
F5989_RS06405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F5989_RS06410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
F5989_RS06415	COG0037	tRNA processing
F5989_RS06435	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F5989_RS06440	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F5989_RS06445	COG0193	aminoacyl-tRNA hydrolase activity
F5989_RS06450	COG0012	GTP binding
F5989_RS06460	COG0592	DNA-directed DNA polymerase activity
F5989_RS06465	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F5989_RS06470	COG1475	DNA binding
F5989_RS06475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F5989_RS06480	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F5989_RS06510	COG0488	(ABC) transporter
F5989_RS06515	COG0180	Tryptophanyl-tRNA synthetase
F5989_RS06520	COG0517	IMP dehydrogenase activity
F5989_RS06520	COG0516	GMP reductase activity
F5989_RS06525	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F5989_RS06540	COG0612	Peptidase, M16
F5989_RS06550	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F5989_RS06555	COG1122	ATPase activity
F5989_RS06560	COG1122	ATPase activity
F5989_RS06565	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
F5989_RS06575	COG0741	lytic transglycosylase activity
F5989_RS06580	COG0482	sulfurtransferase activity
F5989_RS06590	COG0445	tRNA wobble uridine modification
F5989_RS06600	COG0359	binds to the 23S rRNA
F5989_RS06605	COG0305	Participates in initiation and elongation during chromosome replication
F5989_RS06620	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F5989_RS06645	COG2151	metal-sulfur cluster biosynthetic enzyme
F5989_RS06650	COG0129	dihydroxy-acid dehydratase activity
F5989_RS06655	COG1012	belongs to the aldehyde dehydrogenase family
F5989_RS06665	COG1733	regulation of RNA biosynthetic process
F5989_RS06680	COG2094	Belongs to the DNA glycosylase MPG family
F5989_RS06705	COG1028	Short-chain dehydrogenase reductase Sdr
F5989_RS06710	COG0789	Transcriptional regulator
F5989_RS06730	COG2814	Major facilitator Superfamily
F5989_RS06735	COG0640	Transcriptional regulator
F5989_RS06755	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F5989_RS06760	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F5989_RS06765	COG0531	amino acid
F5989_RS06770	COG0124	histidyl-tRNA synthetase
F5989_RS06775	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F5989_RS06780	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F5989_RS06785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F5989_RS06790	COG0018	arginyl-trna synthetase
F5989_RS06805	COG1438	arginine binding
F5989_RS06815	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F5989_RS06825	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F5989_RS06830	COG0632	four-way junction helicase activity
F5989_RS06835	COG0519	Catalyzes the synthesis of GMP from XMP
F5989_RS06840	COG1546	Belongs to the CinA family
F5989_RS06840	COG1058	Belongs to the CinA family
F5989_RS06845	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F5989_RS06850	COG1393	Belongs to the ArsC family
F5989_RS06875	COG4472	Bacterial protein of unknown function (DUF965)
F5989_RS06880	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F5989_RS06885	COG3906	Belongs to the UPF0473 family
F5989_RS06920	COG3022	response to hydroperoxide
F5989_RS06925	COG0428	transporter
F5989_RS06930	COG0463	Glycosyl transferase, family 2
F5989_RS06940	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F5989_RS06950	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F5989_RS06960	COG0583	DNA-binding transcription factor activity
F5989_RS06965	COG2855	membrane
F5989_RS06990	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
F5989_RS07005	COG1136	(ABC) transporter
F5989_RS07005	COG0577	efflux transmembrane transporter activity
F5989_RS07010	COG1250	3-hydroxyacyl-CoA dehydrogenase
F5989_RS07050	COG2217	Heavy metal translocating P-type atpase
F5989_RS07065	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F5989_RS07085	COG2264	protein methyltransferase activity
F5989_RS07090	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F5989_RS07095	COG1609	Transcriptional regulator
F5989_RS07110	COG2190	(PTS) system
F5989_RS07110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F5989_RS07110	COG1263	PTS System
F5989_RS07125	COG1490	D-aminoacyl-tRNA deacylase activity
F5989_RS07130	COG5297	Belongs to the glycosyl hydrolase family 6
F5989_RS07145	COG2188	Transcriptional regulator
F5989_RS07150	COG1263	PTS System
F5989_RS07150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F5989_RS07155	COG0366	Alpha amylase catalytic
F5989_RS07160	COG3590	peptidase
F5989_RS07165	COG1619	proteins homologs of microcin C7 resistance protein MccF
F5989_RS07180	COG0052	Belongs to the universal ribosomal protein uS2 family
F5989_RS07185	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F5989_RS07190	COG4463	regulation of RNA biosynthetic process
F5989_RS07195	COG0542	response to heat
F5989_RS07200	COG1621	beta-fructofuranosidase activity
F5989_RS07210	COG0051	transcription antitermination factor activity, RNA binding
F5989_RS07215	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F5989_RS07225	COG0089	rRNA binding
F5989_RS07230	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F5989_RS07240	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F5989_RS07245	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F5989_RS07250	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F5989_RS07255	COG0255	Belongs to the universal ribosomal protein uL29 family
F5989_RS07260	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F5989_RS07265	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F5989_RS07270	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F5989_RS07275	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F5989_RS07280	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F5989_RS07285	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F5989_RS07290	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F5989_RS07300	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F5989_RS07305	COG1841	ribosomal large subunit assembly
F5989_RS07310	COG0200	Binds to the 23S rRNA
F5989_RS07315	COG0201	protein transport
F5989_RS07320	COG0563	adenylate kinase activity
F5989_RS07325	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F5989_RS07335	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F5989_RS07340	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F5989_RS07345	COG0202	RNA polymerase activity
F5989_RS07350	COG0203	ribosomal protein L17
F5989_RS07390	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F5989_RS07400	COG1121	(ABC) transporter
F5989_RS07405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F5989_RS07410	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F5989_RS07415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F5989_RS07420	COG0085	RNA polymerase activity
F5989_RS07425	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F5989_RS07435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F5989_RS07440	COG1459	type II secretion system
F5989_RS07470	COG0827	DNA restriction-modification system
F5989_RS07475	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F5989_RS07495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F5989_RS07500	COG1363	Peptidase, m42
F5989_RS07510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F5989_RS07515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F5989_RS07515	COG0072	phenylalanine-tRNA ligase activity
F5989_RS07520	COG1846	Transcriptional regulator
F5989_RS07540	COG4585	Histidine kinase
F5989_RS07545	COG2197	response regulator
F5989_RS07565	COG3715	PTS system
F5989_RS07570	COG3716	PTS system mannose fructose sorbose family IID component
F5989_RS07580	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F5989_RS07585	COG0459	protein refolding
F5989_RS07595	COG0564	pseudouridine synthase activity
F5989_RS07600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F5989_RS07630	COG0495	leucyl-tRNA aminoacylation
F5989_RS07635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F5989_RS07640	COG1464	Belongs to the NlpA lipoprotein family
F5989_RS07645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F5989_RS07650	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F5989_RS07660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F5989_RS07670	COG4720	Psort location CytoplasmicMembrane, score
F5989_RS07675	COG1122	ATPase activity
F5989_RS07685	COG0357	Ribosomal RNA small subunit methyltransferase G
F5989_RS07690	COG1704	LemA family
F5989_RS07695	COG0501	Belongs to the peptidase M48B family
F5989_RS07700	COG4591	ABC-type transport system involved in lipoprotein release permease component
F5989_RS07705	COG1136	(ABC) transporter
F5989_RS07720	COG0745	RESPONSE REGULATOR receiver
F5989_RS07725	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F5989_RS07735	COG1484	DNA-dependent DNA replication
F5989_RS07740	COG1160	GTP binding
F5989_RS07750	COG0586	Pfam SNARE associated Golgi protein
F5989_RS07760	COG3290	protein histidine kinase activity
F5989_RS07840	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F5989_RS07860	COG2274	protein secretion by the type I secretion system
F5989_RS07865	COG3716	PTS system mannose fructose sorbose family IID component
F5989_RS07870	COG3715	PTS system
F5989_RS07885	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F5989_RS07890	COG0681	Belongs to the peptidase S26 family
F5989_RS07895	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F5989_RS07910	COG1193	negative regulation of DNA recombination
F5989_RS07915	COG3118	belongs to the thioredoxin family
F5989_RS07920	COG1063	alcohol dehydrogenase
F5989_RS07925	COG1194	a g-specific adenine glycosylase
F5989_RS07940	COG0360	Binds together with S18 to 16S ribosomal RNA
F5989_RS07945	COG0629	single-stranded DNA binding
F5989_RS07950	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F5989_RS07985	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F5989_RS07990	COG0006	proline dipeptidase activity
F5989_RS07995	COG2131	deaminase
F5989_RS08000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F5989_RS08005	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F5989_RS08015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F5989_RS08020	COG1609	Transcriptional regulator
F5989_RS08025	COG1621	beta-fructofuranosidase activity
F5989_RS08030	COG2190	(PTS) system
F5989_RS08030	COG1263	PTS System
F5989_RS08030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F5989_RS08035	COG1940	carbohydrate kinase activity
F5989_RS08040	COG1482	cell wall glycoprotein biosynthetic process
F5989_RS08045	COG0653	protein targeting
F5989_RS08050	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F5989_RS08055	COG0736	holo-[acyl-carrier-protein] synthase activity
F5989_RS08060	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F5989_RS08065	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F5989_RS08075	COG0252	asparaginase activity
F5989_RS08080	COG0561	phosphatase activity
F5989_RS08090	COG1268	BioY protein
F5989_RS08095	COG0436	Aminotransferase
F5989_RS08100	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
F5989_RS08105	COG1335	isochorismatase
F5989_RS08110	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F5989_RS08115	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F5989_RS08120	COG0154	amidase activity
F5989_RS08125	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F5989_RS08130	COG0697	spore germination
F5989_RS08135	COG1819	glycosyl
F5989_RS08155	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
F5989_RS08160	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
F5989_RS08165	COG1534	Rna-binding protein
F5989_RS08170	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F5989_RS08175	COG1713	HD superfamily hydrolase involved in NAD metabolism
F5989_RS08180	COG0799	negative regulation of ribosome biogenesis
F5989_RS08185	COG2226	methyltransferase
F5989_RS08200	COG1323	Belongs to the UPF0348 family
F5989_RS08205	COG0789	Transcriptional regulator
F5989_RS08210	COG0217	transcriptional regulatory protein
F5989_RS08220	COG1862	Preprotein translocase
F5989_RS08225	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F5989_RS08230	COG4589	Belongs to the CDS family
F5989_RS08240	COG0442	prolyl-tRNA aminoacylation
F5989_RS08300	COG3557	Belongs to the UPF0374 family
F5989_RS08305	COG2137	regulation of response to DNA damage stimulus
F5989_RS08310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F5989_RS08315	COG1780	Probably involved in ribonucleotide reductase function
F5989_RS08355	COG0525	valine-tRNA ligase activity
F5989_RS08360	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F5989_RS08440	COG0527	aspartate kinase activity
F5989_RS08445	COG0546	phosphoglycolate phosphatase activity
F5989_RS08450	COG1024	Enoyl-CoA hydratase
F5989_RS08455	COG1846	Transcriptional regulator
F5989_RS08460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F5989_RS08475	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F5989_RS08480	COG1028	Short-chain dehydrogenase reductase Sdr
F5989_RS08485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F5989_RS08495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F5989_RS08500	COG0439	Biotin carboxylase
F5989_RS08515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F5989_RS08525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F5989_RS08535	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F5989_RS08540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F5989_RS08545	COG0706	membrane insertase activity
F5989_RS08550	COG1254	Belongs to the acylphosphatase family
F5989_RS08555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F5989_RS08570	COG0019	diaminopimelate decarboxylase activity
F5989_RS08575	COG3763	UPF0154 protein
F5989_RS08580	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F5989_RS08585	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F5989_RS08600	COG0582	viral genome integration into host DNA
F5989_RS08605	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F5989_RS08610	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F5989_RS08615	COG1187	pseudouridine synthase activity
F5989_RS08620	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F5989_RS08625	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F5989_RS08630	COG0569	domain protein
F5989_RS08655	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
F5989_RS08660	COG0671	phosphoesterase, PA-phosphatase related
F5989_RS08665	COG1380	Effector of murein hydrolase LrgA
F5989_RS08670	COG1346	cytolysis
F5989_RS08675	COG1242	4 iron, 4 sulfur cluster binding
F5989_RS08680	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
F5989_RS08685	COG1119	ATPase activity
F5989_RS08690	COG0628	permease
F5989_RS08695	COG1253	flavin adenine dinucleotide binding
F5989_RS08700	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F5989_RS08710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5989_RS08715	COG1696	Membrane protein involved in D-alanine export
F5989_RS08720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F5989_RS08725	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
F5989_RS08730	COG1227	inorganic diphosphatase activity
F5989_RS08740	COG2378	regulation of single-species biofilm formation
F5989_RS08745	COG0693	protein deglycase activity
F5989_RS08770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F5989_RS08775	COG2244	polysaccharide biosynthetic process
F5989_RS08780	COG0626	cystathionine gamma-synthase activity
F5989_RS08785	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
F5989_RS08790	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F5989_RS08795	COG0740	serine-type endopeptidase activity
F5989_RS08805	COG4471	UPF0298 protein
F5989_RS08815	COG0559	Belongs to the binding-protein-dependent transport system permease family
F5989_RS08835	COG0517	IMP dehydrogenase activity
F5989_RS08840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F5989_RS08845	COG0470	DNA polymerase III
F5989_RS08850	COG1774	PSP1 C-terminal conserved region
F5989_RS08855	COG4467	Involved in initiation control of chromosome replication
F5989_RS08865	COG0004	ammonium transporteR
F5989_RS08870	COG0347	Belongs to the P(II) protein family
F5989_RS08875	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F5989_RS08890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F5989_RS08895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F5989_RS08900	COG1393	Belongs to the ArsC family
F5989_RS08905	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F5989_RS08910	COG0708	Exodeoxyribonuclease III
F5989_RS08920	COG0640	Transcriptional regulator
F5989_RS08955	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F5989_RS08955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F5989_RS08975	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F5989_RS09000	COG1674	ftsk spoiiie
F5989_RS09010	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F5989_RS09015	COG0081	regulation of translation
F5989_RS09020	COG0528	UMP kinase activity
F5989_RS09025	COG0233	cytoplasmic translational termination
F5989_RS09035	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F5989_RS09040	COG4479	Belongs to the UPF0346 family
F5989_RS09045	COG1702	phosphate starvation-inducible protein PhoH
F5989_RS09050	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F5989_RS09055	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
F5989_RS09060	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F5989_RS09075	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F5989_RS09080	COG0237	dephospho-CoA kinase activity
F5989_RS09085	COG2264	protein methyltransferase activity
F5989_RS09090	COG2814	Major facilitator Superfamily
F5989_RS09095	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F5989_RS09105	COG0557	exoribonuclease II activity
F5989_RS09110	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F5989_RS09115	COG0346	lactoylglutathione lyase activity
F5989_RS09120	COG0778	Nitroreductase
F5989_RS09130	COG2723	6-phospho-beta-galactosidase activity
F5989_RS09135	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F5989_RS09140	COG3711	transcriptional antiterminator
F5989_RS09140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F5989_RS09145	COG1447	Phosphotransferase system cellobiose-specific component IIA
F5989_RS09155	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F5989_RS09175	COG1609	Transcriptional regulator
F5989_RS09190	COG0438	transferase activity, transferring glycosyl groups
F5989_RS09205	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F5989_RS09215	COG4716	Myosin-crossreactive antigen
F5989_RS09220	COG1956	GAF domain-containing protein
F5989_RS09225	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F5989_RS09260	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F5989_RS09265	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F5989_RS09270	COG3842	ATPase activity
F5989_RS09275	COG3833	ABC-type maltose transport systems, permease component
F5989_RS09280	COG1175	transmembrane transport
F5989_RS09290	COG1609	Transcriptional regulator
F5989_RS09295	COG1640	4-alpha-glucanotransferase
F5989_RS09300	COG0058	SHG alpha-glucan phosphorylase activity
F5989_RS09305	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F5989_RS09310	COG0569	domain protein
F5989_RS09330	COG4109	DRTGG domain
F5989_RS09340	COG1295	ribonuclease BN
F5989_RS09360	COG1131	(ABC) transporter
F5989_RS09370	COG4585	Histidine kinase
F5989_RS09375	COG2197	response regulator
F5989_RS09385	COG4708	membrane
F5989_RS09390	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F5989_RS09395	COG1597	lipid kinase activity
F5989_RS09400	COG1523	belongs to the glycosyl hydrolase 13 family
F5989_RS09405	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F5989_RS09410	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F5989_RS09415	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F5989_RS09420	COG0297	glycogen (starch) synthase activity
F5989_RS09425	COG0058	SHG alpha-glucan phosphorylase activity
F5989_RS09435	COG0356	it plays a direct role in the translocation of protons across the membrane
F5989_RS09440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F5989_RS09445	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F5989_RS09450	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F5989_RS09455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F5989_RS09460	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F5989_RS09465	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F5989_RS09475	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F5989_RS09490	COG0765	amino acid transport
F5989_RS09495	COG0765	amino acid transport
F5989_RS09500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F5989_RS09510	COG0745	RESPONSE REGULATOR receiver
F5989_RS09515	COG5002	protein histidine kinase activity
F5989_RS09520	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
F5989_RS09525	COG0571	ribonuclease III activity
F5989_RS09530	COG1196	nuclear chromosome segregation
F5989_RS09535	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F5989_RS09545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F5989_RS09545	COG0072	phenylalanine-tRNA ligase activity
F5989_RS09560	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
F5989_RS09565	COG1074	ATP-dependent DNA helicase activity
F5989_RS09570	COG1349	DNA-binding transcription factor activity
F5989_RS09575	COG0698	ribose 5-phosphate isomerase
F5989_RS09580	COG0698	ribose 5-phosphate isomerase
F5989_RS09585	COG1105	Belongs to the carbohydrate kinase PfkB family
F5989_RS09590	COG3684	Belongs to the aldolase LacD family
F5989_RS09595	COG1447	Phosphotransferase system cellobiose-specific component IIA
F5989_RS09600	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F5989_RS09600	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F5989_RS09605	COG2723	6-phospho-beta-galactosidase activity
F5989_RS09630	COG1401	restriction endodeoxyribonuclease activity
F5989_RS09660	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F5989_RS09665	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F5989_RS09675	COG1234	tRNA 3'-trailer cleavage
F5989_RS09680	COG0300	oxidoreductase activity
F5989_RS09685	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
F5989_RS09685	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F5989_RS09690	COG2378	regulation of single-species biofilm formation
F5989_RS09710	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F5989_RS09715	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
F5989_RS09725	COG2384	SAM-dependent methyltransferase
F5989_RS09735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F5989_RS09740	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
F5989_RS09755	COG1088	dTDP-glucose 4,6-dehydratase activity
F5989_RS09765	COG1051	belongs to the nudix hydrolase family
F5989_RS09770	COG0628	permease
F5989_RS09780	COG0028	Belongs to the TPP enzyme family
F5989_RS09785	COG3527	Alpha-acetolactate decarboxylase
F5989_RS09790	COG1113	amino acid transport
F5989_RS09795	COG1293	RNA-binding protein homologous to eukaryotic snRNP
F5989_RS09830	COG4808	Protein conserved in bacteria
F5989_RS09840	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F5989_RS09855	COG1215	transferase activity, transferring glycosyl groups
F5989_RS09865	COG0488	(ABC) transporter
F5989_RS09870	COG3442	glutamine amidotransferase
F5989_RS09875	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F5989_RS09880	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
F5989_RS09890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F5989_RS09895	COG0542	response to heat
F5989_RS09905	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F5989_RS09910	COG0022	dehydrogenase e1 component
F5989_RS09915	COG0508	dehydrogenase complex catalyzes the overall conversion of
F5989_RS09920	COG2249	NAD(P)H dehydrogenase (quinone) activity
F5989_RS09930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F5989_RS09940	COG1051	belongs to the nudix hydrolase family
F5989_RS09945	COG0647	UMP catabolic process
F5989_RS09955	COG0577	efflux transmembrane transporter activity
F5989_RS09955	COG1136	(ABC) transporter
F5989_RS09965	COG3976	FMN-binding domain protein
F5989_RS09965	COG1053	succinate dehydrogenase
F5989_RS09980	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
F5989_RS09985	COG1518	maintenance of DNA repeat elements
F5989_RS09990	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
F5989_RS10010	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F5989_RS10035	COG0481	GTPase activity
F5989_RS10060	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
F5989_RS10070	COG0673	inositol 2-dehydrogenase activity
F5989_RS10075	COG0572	uridine kinase
F5989_RS10085	COG0473	3-isopropylmalate dehydrogenase activity
F5989_RS10090	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F5989_RS10095	COG0066	3-isopropylmalate dehydratase activity
F5989_RS10110	COG0456	acetyltransferase
F5989_RS10110	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A