locus-tag	class	description
APQ13_RS00010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APQ13_RS00015	COG0706	membrane insertase activity
APQ13_RS00020	COG1254	Belongs to the acylphosphatase family
APQ13_RS00025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APQ13_RS00040	COG0019	diaminopimelate decarboxylase activity
APQ13_RS00045	COG3763	UPF0154 protein
APQ13_RS00050	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
APQ13_RS00055	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APQ13_RS00070	COG0582	viral genome integration into host DNA
APQ13_RS00075	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
APQ13_RS00080	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
APQ13_RS00085	COG1187	pseudouridine synthase activity
APQ13_RS00090	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
APQ13_RS00095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
APQ13_RS00100	COG0569	domain protein
APQ13_RS00125	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
APQ13_RS00130	COG0671	phosphoesterase, PA-phosphatase related
APQ13_RS00135	COG1380	Effector of murein hydrolase LrgA
APQ13_RS00140	COG1346	cytolysis
APQ13_RS00145	COG1242	4 iron, 4 sulfur cluster binding
APQ13_RS00150	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
APQ13_RS00155	COG1119	ATPase activity
APQ13_RS00160	COG0628	permease
APQ13_RS00165	COG1253	flavin adenine dinucleotide binding
APQ13_RS00170	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APQ13_RS00175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APQ13_RS00180	COG1696	Membrane protein involved in D-alanine export
APQ13_RS00185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APQ13_RS00190	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
APQ13_RS00195	COG1227	inorganic diphosphatase activity
APQ13_RS00205	COG2378	regulation of single-species biofilm formation
APQ13_RS00210	COG0693	protein deglycase activity
APQ13_RS00235	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APQ13_RS00240	COG2244	polysaccharide biosynthetic process
APQ13_RS00245	COG0626	cystathionine gamma-synthase activity
APQ13_RS00250	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
APQ13_RS00255	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APQ13_RS00260	COG0740	serine-type endopeptidase activity
APQ13_RS00270	COG4471	UPF0298 protein
APQ13_RS00280	COG0559	Belongs to the binding-protein-dependent transport system permease family
APQ13_RS00300	COG0517	IMP dehydrogenase activity
APQ13_RS00305	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APQ13_RS00310	COG0470	DNA polymerase III
APQ13_RS00315	COG1774	PSP1 C-terminal conserved region
APQ13_RS00320	COG4467	Involved in initiation control of chromosome replication
APQ13_RS00330	COG0004	ammonium transporteR
APQ13_RS00335	COG0347	Belongs to the P(II) protein family
APQ13_RS00340	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
APQ13_RS00350	COG0454	-acetyltransferase
APQ13_RS00355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APQ13_RS00360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APQ13_RS00365	COG1393	Belongs to the ArsC family
APQ13_RS00370	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APQ13_RS00375	COG0708	Exodeoxyribonuclease III
APQ13_RS00385	COG0640	Transcriptional regulator
APQ13_RS00420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APQ13_RS00420	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APQ13_RS00435	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APQ13_RS00460	COG1674	ftsk spoiiie
APQ13_RS00470	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APQ13_RS00475	COG0081	regulation of translation
APQ13_RS00480	COG0528	UMP kinase activity
APQ13_RS00485	COG0233	cytoplasmic translational termination
APQ13_RS00495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APQ13_RS00500	COG4479	Belongs to the UPF0346 family
APQ13_RS00505	COG1702	phosphate starvation-inducible protein PhoH
APQ13_RS00510	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APQ13_RS00515	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
APQ13_RS00520	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APQ13_RS00535	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
APQ13_RS00540	COG0237	dephospho-CoA kinase activity
APQ13_RS00545	COG2264	protein methyltransferase activity
APQ13_RS00550	COG2814	Major facilitator Superfamily
APQ13_RS00555	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APQ13_RS00565	COG0557	exoribonuclease II activity
APQ13_RS00570	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APQ13_RS00575	COG0346	lactoylglutathione lyase activity
APQ13_RS00580	COG0778	Nitroreductase
APQ13_RS00585	COG2723	6-phospho-beta-galactosidase activity
APQ13_RS00590	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APQ13_RS00595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APQ13_RS00595	COG3711	transcriptional antiterminator
APQ13_RS00600	COG1447	Phosphotransferase system cellobiose-specific component IIA
APQ13_RS00610	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APQ13_RS00630	COG1609	Transcriptional regulator
APQ13_RS00645	COG0438	transferase activity, transferring glycosyl groups
APQ13_RS00660	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APQ13_RS00670	COG4716	Myosin-crossreactive antigen
APQ13_RS00675	COG1956	GAF domain-containing protein
APQ13_RS00680	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APQ13_RS00715	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APQ13_RS00720	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APQ13_RS00725	COG3842	ATPase activity
APQ13_RS00730	COG3833	ABC-type maltose transport systems, permease component
APQ13_RS00735	COG1175	transmembrane transport
APQ13_RS00745	COG1609	Transcriptional regulator
APQ13_RS00750	COG1640	4-alpha-glucanotransferase
APQ13_RS00755	COG0058	SHG alpha-glucan phosphorylase activity
APQ13_RS00760	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
APQ13_RS00765	COG0569	domain protein
APQ13_RS00785	COG4109	DRTGG domain
APQ13_RS00795	COG1295	ribonuclease BN
APQ13_RS00815	COG1131	(ABC) transporter
APQ13_RS00825	COG4585	Histidine kinase
APQ13_RS00830	COG2197	response regulator
APQ13_RS00840	COG4708	membrane
APQ13_RS00845	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APQ13_RS00850	COG1597	lipid kinase activity
APQ13_RS00855	COG1523	belongs to the glycosyl hydrolase 13 family
APQ13_RS00865	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APQ13_RS00870	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APQ13_RS00875	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APQ13_RS00880	COG0297	glycogen (starch) synthase activity
APQ13_RS00885	COG0058	SHG alpha-glucan phosphorylase activity
APQ13_RS00895	COG0356	it plays a direct role in the translocation of protons across the membrane
APQ13_RS00900	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APQ13_RS00905	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APQ13_RS00910	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APQ13_RS00915	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APQ13_RS00920	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APQ13_RS00925	COG0355	proton-transporting ATP synthase activity, rotational mechanism
APQ13_RS00935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APQ13_RS00950	COG0765	amino acid transport
APQ13_RS00955	COG0765	amino acid transport
APQ13_RS00960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APQ13_RS00970	COG0745	RESPONSE REGULATOR receiver
APQ13_RS00975	COG5002	protein histidine kinase activity
APQ13_RS00980	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
APQ13_RS00985	COG0571	ribonuclease III activity
APQ13_RS00990	COG1196	nuclear chromosome segregation
APQ13_RS00995	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APQ13_RS01005	COG0072	phenylalanine-tRNA ligase activity
APQ13_RS01005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APQ13_RS01020	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
APQ13_RS01025	COG1074	ATP-dependent DNA helicase activity
APQ13_RS01030	COG1349	DNA-binding transcription factor activity
APQ13_RS01035	COG0698	ribose 5-phosphate isomerase
APQ13_RS01040	COG0698	ribose 5-phosphate isomerase
APQ13_RS01045	COG1105	Belongs to the carbohydrate kinase PfkB family
APQ13_RS01050	COG3684	Belongs to the aldolase LacD family
APQ13_RS01055	COG1447	Phosphotransferase system cellobiose-specific component IIA
APQ13_RS01060	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APQ13_RS01060	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APQ13_RS01065	COG2723	6-phospho-beta-galactosidase activity
APQ13_RS01090	COG1401	restriction endodeoxyribonuclease activity
APQ13_RS01120	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APQ13_RS01125	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APQ13_RS01135	COG1234	tRNA 3'-trailer cleavage
APQ13_RS01140	COG0300	oxidoreductase activity
APQ13_RS01145	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
APQ13_RS01145	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
APQ13_RS01150	COG2378	regulation of single-species biofilm formation
APQ13_RS01170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APQ13_RS01175	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
APQ13_RS01185	COG2384	SAM-dependent methyltransferase
APQ13_RS01195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APQ13_RS01200	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
APQ13_RS01210	COG1088	dTDP-glucose 4,6-dehydratase activity
APQ13_RS01220	COG1051	belongs to the nudix hydrolase family
APQ13_RS01225	COG0628	permease
APQ13_RS01235	COG0028	Belongs to the TPP enzyme family
APQ13_RS01240	COG3527	Alpha-acetolactate decarboxylase
APQ13_RS01245	COG1113	amino acid transport
APQ13_RS01250	COG1293	RNA-binding protein homologous to eukaryotic snRNP
APQ13_RS01285	COG4808	Protein conserved in bacteria
APQ13_RS01295	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
APQ13_RS01310	COG1215	transferase activity, transferring glycosyl groups
APQ13_RS01320	COG0488	(ABC) transporter
APQ13_RS01325	COG3442	glutamine amidotransferase
APQ13_RS01330	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APQ13_RS01335	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
APQ13_RS01345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APQ13_RS01350	COG0542	response to heat
APQ13_RS01360	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
APQ13_RS01365	COG0022	dehydrogenase e1 component
APQ13_RS01370	COG0508	dehydrogenase complex catalyzes the overall conversion of
APQ13_RS01375	COG2249	NAD(P)H dehydrogenase (quinone) activity
APQ13_RS01385	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APQ13_RS01395	COG1051	belongs to the nudix hydrolase family
APQ13_RS01400	COG0647	UMP catabolic process
APQ13_RS01410	COG0577	efflux transmembrane transporter activity
APQ13_RS01410	COG1136	(ABC) transporter
APQ13_RS01420	COG1053	succinate dehydrogenase
APQ13_RS01420	COG3976	FMN-binding domain protein
APQ13_RS01435	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
APQ13_RS01440	COG1518	maintenance of DNA repeat elements
APQ13_RS01445	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
APQ13_RS01465	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APQ13_RS01490	COG0481	GTPase activity
APQ13_RS01515	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
APQ13_RS01525	COG0673	inositol 2-dehydrogenase activity
APQ13_RS01530	COG0572	uridine kinase
APQ13_RS01540	COG0473	3-isopropylmalate dehydrogenase activity
APQ13_RS01545	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APQ13_RS01550	COG0066	3-isopropylmalate dehydratase activity
APQ13_RS01565	COG0456	acetyltransferase
APQ13_RS01565	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
APQ13_RS01590	COG2801	Transposase and inactivated derivatives
APQ13_RS01595	COG2226	methyltransferase
APQ13_RS01600	COG1136	(ABC) transporter
APQ13_RS01615	COG1309	transcriptional regulator
APQ13_RS01645	COG1136	(ABC) transporter
APQ13_RS01730	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APQ13_RS01740	COG2884	Cell division ATP-binding protein ftsE
APQ13_RS01745	COG2177	Part of the ABC transporter FtsEX involved in
APQ13_RS01780	COG1122	ATPase activity
APQ13_RS01790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APQ13_RS01790	COG1199	ATP-dependent helicase activity
APQ13_RS01795	COG0436	Aminotransferase
APQ13_RS01800	COG0017	Asparaginyl-tRNA synthetase
APQ13_RS01805	COG0371	Dehydrogenase
APQ13_RS01810	COG0251	oxidation-reduction process
APQ13_RS01820	COG1660	Displays ATPase and GTPase activities
APQ13_RS01845	COG2226	methyltransferase
APQ13_RS01860	COG0254	rRNA binding
APQ13_RS01865	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
APQ13_RS01870	COG0625	glutathione transferase activity
APQ13_RS01875	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
APQ13_RS01880	COG0716	FMN binding
APQ13_RS01895	COG0077	Prephenate dehydratase
APQ13_RS01895	COG1605	Chorismate mutase
APQ13_RS01900	COG0038	chloride channel
APQ13_RS01905	COG0038	chloride channel
APQ13_RS01910	COG0335	large ribosomal subunit rRNA binding
APQ13_RS01920	COG2814	Major facilitator Superfamily
APQ13_RS01945	COG0772	Belongs to the SEDS family
APQ13_RS01960	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
APQ13_RS01970	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APQ13_RS01975	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
APQ13_RS01980	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
APQ13_RS01985	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APQ13_RS01990	COG0560	Phosphoserine phosphatase
APQ13_RS01995	COG0131	Imidazoleglycerol-phosphate dehydratase
APQ13_RS02005	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APQ13_RS02010	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APQ13_RS02015	COG0107	imidazoleglycerol-phosphate synthase activity
APQ13_RS02020	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APQ13_RS02050	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
APQ13_RS02060	COG4974	Belongs to the 'phage' integrase family
APQ13_RS02085	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APQ13_RS02135	COG0148	phosphopyruvate hydratase activity
APQ13_RS02145	COG1011	Hydrolase
APQ13_RS02160	COG0322	excinuclease ABC activity
APQ13_RS02170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APQ13_RS02175	COG1573	uracil-dna glycosylase
APQ13_RS02195	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APQ13_RS02200	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
APQ13_RS02205	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
APQ13_RS02230	COG0813	purine-nucleoside phosphorylase activity
APQ13_RS02245	COG0543	2 iron, 2 sulfur cluster binding
APQ13_RS02250	COG0167	dihydroorotate dehydrogenase activity
APQ13_RS02255	COG0284	orotidine-5'-phosphate decarboxylase activity
APQ13_RS02260	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APQ13_RS02265	COG1881	PFAM PEBP family protein
APQ13_RS02270	COG2315	Protein conserved in bacteria
APQ13_RS02280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APQ13_RS02285	COG0765	amino acid transport
APQ13_RS02290	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
APQ13_RS02300	COG0737	Belongs to the 5'-nucleotidase family
APQ13_RS02305	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
APQ13_RS02310	COG0187	DNA topoisomerase II activity
APQ13_RS02335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APQ13_RS02355	COG0539	negative regulation of cytoplasmic translation
APQ13_RS02385	COG1131	(ABC) transporter
APQ13_RS02390	COG1725	Transcriptional regulator
APQ13_RS02400	COG0205	6-phosphofructokinase activity
APQ13_RS02405	COG0469	pyruvate kinase activity
APQ13_RS02410	COG2261	transglycosylase associated protein
APQ13_RS02420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APQ13_RS02425	COG2213	PTS system mannitol-specific
APQ13_RS02430	COG3711	transcriptional antiterminator
APQ13_RS02435	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
APQ13_RS02440	COG0246	Mannitol dehydrogenase
APQ13_RS02445	COG2824	Alkylphosphonate utilization operon protein PhnA
APQ13_RS02450	COG0765	amino acid transport
APQ13_RS02455	COG1126	abc transporter atp-binding protein
APQ13_RS02460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APQ13_RS02465	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
APQ13_RS02470	COG1115	amino acid carrier protein
APQ13_RS02475	COG0210	DNA helicase
APQ13_RS02480	COG2873	o-acetylhomoserine
APQ13_RS02500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APQ13_RS02525	COG2375	cellular response to nickel ion
APQ13_RS02525	COG1132	(ABC) transporter
APQ13_RS02530	COG1132	(ABC) transporter
APQ13_RS02535	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
APQ13_RS02585	COG0745	RESPONSE REGULATOR receiver
APQ13_RS02590	COG2205	protein histidine kinase activity
APQ13_RS02595	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APQ13_RS02600	COG0196	riboflavin kinase activity
APQ13_RS02605	COG1393	Belongs to the ArsC family
APQ13_RS02610	COG4476	Belongs to the UPF0223 family
APQ13_RS02615	COG0483	inositol monophosphate 1-phosphatase activity
APQ13_RS02620	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APQ13_RS02620	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
APQ13_RS02630	COG0573	inorganic phosphate transmembrane transporter activity
APQ13_RS02635	COG0581	inorganic phosphate transmembrane transporter activity
APQ13_RS02640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APQ13_RS02645	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APQ13_RS02650	COG0704	Plays a role in the regulation of phosphate uptake
APQ13_RS02665	COG0745	RESPONSE REGULATOR receiver
APQ13_RS02670	COG5002	protein histidine kinase activity
APQ13_RS02675	COG0268	Binds directly to 16S ribosomal RNA
APQ13_RS02680	COG1072	(Pantothenic acid kinase))
APQ13_RS02685	COG2813	Specifically methylates the guanine in position
APQ13_RS02690	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
APQ13_RS02695	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
APQ13_RS02700	COG0295	cytidine deaminase activity
APQ13_RS02705	COG1744	ABC transporter substrate-binding protein PnrA-like
APQ13_RS02710	COG3845	ABC transporter
APQ13_RS02715	COG4603	Belongs to the binding-protein-dependent transport system permease family
APQ13_RS02720	COG1079	Belongs to the binding-protein-dependent transport system permease family
APQ13_RS02735	COG0039	L-malate dehydrogenase activity
APQ13_RS02745	COG3764	Sortase (surface protein transpeptidase)
APQ13_RS02750	COG0346	lactoylglutathione lyase activity
APQ13_RS02765	COG0561	phosphatase activity
APQ13_RS02785	COG0406	alpha-ribazole phosphatase activity
APQ13_RS02795	COG2723	6-phospho-beta-galactosidase activity
APQ13_RS02800	COG0628	permease
APQ13_RS02805	COG1063	alcohol dehydrogenase
APQ13_RS02820	COG1174	glycine betaine transport
APQ13_RS02825	COG1136	(ABC) transporter
APQ13_RS02830	COG0577	efflux transmembrane transporter activity
APQ13_RS02845	COG3976	FMN-binding domain protein
APQ13_RS02845	COG0431	NADPH-dependent FMN reductase
APQ13_RS02845	COG1053	succinate dehydrogenase
APQ13_RS02860	COG1942	4-Oxalocrotonate Tautomerase
APQ13_RS02865	COG1435	thymidine kinase activity
APQ13_RS02870	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APQ13_RS02875	COG2890	protein-(glutamine-N5) methyltransferase activity
APQ13_RS02880	COG0009	L-threonylcarbamoyladenylate synthase
APQ13_RS02885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APQ13_RS02900	COG1132	(ABC) transporter
APQ13_RS02905	COG1132	(ABC) transporter
APQ13_RS02910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APQ13_RS02915	COG4684	Psort location CytoplasmicMembrane, score
APQ13_RS02920	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APQ13_RS02930	COG2759	Belongs to the formate--tetrahydrofolate ligase family
APQ13_RS02935	COG1247	-acetyltransferase
APQ13_RS02955	COG1131	(ABC) transporter
APQ13_RS02965	COG0519	Catalyzes the synthesis of GMP from XMP
APQ13_RS02970	COG2188	Transcriptional regulator
APQ13_RS02980	COG3448	diguanylate cyclase activity
APQ13_RS02980	COG4175	Glycine betaine
APQ13_RS02990	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
APQ13_RS02995	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APQ13_RS03015	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
APQ13_RS03020	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
APQ13_RS03030	COG1104	cysteine desulfurase activity
APQ13_RS03035	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APQ13_RS03040	COG4116	CYTH
APQ13_RS03050	COG2357	RelA SpoT domain protein
APQ13_RS03055	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APQ13_RS03060	COG0564	pseudouridine synthase activity
APQ13_RS03065	COG0280	phosphate acetyltransferase
APQ13_RS03075	COG1131	(ABC) transporter
APQ13_RS03080	COG4221	oxidoreductase activity
APQ13_RS03085	COG1442	glycosyl transferase family 8
APQ13_RS03090	COG0745	RESPONSE REGULATOR receiver
APQ13_RS03095	COG5002	protein histidine kinase activity
APQ13_RS03105	COG1131	(ABC) transporter
APQ13_RS03110	COG4974	Belongs to the 'phage' integrase family
APQ13_RS03135	COG3052	prosthetic group binding
APQ13_RS03145	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
APQ13_RS03150	COG0511	ligase activity, forming carbon-carbon bonds
APQ13_RS03160	COG2851	Citrate transporter
APQ13_RS03170	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
APQ13_RS03175	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
APQ13_RS03180	COG0642	Histidine kinase
APQ13_RS03185	COG0745	RESPONSE REGULATOR receiver
APQ13_RS03195	COG1136	(ABC) transporter
APQ13_RS03200	COG0366	Alpha amylase catalytic
APQ13_RS03200	COG5263	repeat protein
APQ13_RS03205	COG5263	repeat protein
APQ13_RS03205	COG0366	Alpha amylase catalytic
APQ13_RS03210	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
APQ13_RS03215	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APQ13_RS03220	COG0758	DNA mediated transformation
APQ13_RS03235	COG4607	ABC-type enterochelin transport system periplasmic component
APQ13_RS03240	COG4604	ABC transporter, ATP-binding protein
APQ13_RS03245	COG4605	iron ion homeostasis
APQ13_RS03250	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APQ13_RS03255	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APQ13_RS03260	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
APQ13_RS03275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APQ13_RS03280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APQ13_RS03290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APQ13_RS03295	COG4932	domain protein
APQ13_RS03325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APQ13_RS03325	COG2190	(PTS) system
APQ13_RS03325	COG1263	PTS System
APQ13_RS03330	COG3711	transcriptional antiterminator
APQ13_RS03335	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
APQ13_RS03340	COG1177	transmembrane transport
APQ13_RS03345	COG1176	ABC-type spermidine putrescine transport system, permease component I
APQ13_RS03350	COG3842	ATPase activity
APQ13_RS03355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APQ13_RS03375	COG0302	gtp cyclohydrolase
APQ13_RS03380	COG0285	dihydrofolate synthase activity
APQ13_RS03385	COG0083	homoserine kinase activity
APQ13_RS03395	COG0726	polysaccharide deacetylase
APQ13_RS03400	COG1960	acyl-CoA dehydrogenase activity
APQ13_RS03410	COG0222	ribosome binding
APQ13_RS03415	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APQ13_RS03435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APQ13_RS03440	COG2040	homocysteine
APQ13_RS03445	COG0833	amino acid
APQ13_RS03450	COG0218	Necessary for normal cell division and for the maintenance of normal septation
APQ13_RS03455	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APQ13_RS03465	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APQ13_RS03470	COG3201	nicotinamide mononucleotide transporter
APQ13_RS03475	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
APQ13_RS03480	COG3425	synthase
APQ13_RS03495	COG1272	protein, Hemolysin III
APQ13_RS03500	COG1304	FMN binding
APQ13_RS03515	COG1126	abc transporter atp-binding protein
APQ13_RS03520	COG0765	amino acid transport
APQ13_RS03525	COG0765	amino acid transport
APQ13_RS03530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APQ13_RS03540	COG0583	DNA-binding transcription factor activity
APQ13_RS03545	COG3759	membrane
APQ13_RS03555	COG0745	RESPONSE REGULATOR receiver
APQ13_RS03560	COG2357	RelA SpoT domain protein
APQ13_RS03570	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
APQ13_RS03575	COG1132	(ABC) transporter
APQ13_RS03590	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
APQ13_RS03600	COG0602	queuosine metabolic process
APQ13_RS03605	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
APQ13_RS03615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
APQ13_RS03625	COG5263	repeat protein
APQ13_RS03625	COG0366	Alpha amylase catalytic
APQ13_RS03650	COG0488	(ABC) transporter
APQ13_RS03655	COG0617	tRNA 3'-terminal CCA addition
APQ13_RS03660	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
APQ13_RS03665	COG1307	EDD domain protein, DegV family
APQ13_RS03700	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APQ13_RS03705	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
APQ13_RS03710	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
APQ13_RS03715	COG1609	Transcriptional regulator
APQ13_RS03720	COG0366	Alpha amylase catalytic
APQ13_RS03725	COG3842	ATPase activity
APQ13_RS03730	COG0366	Alpha amylase catalytic
APQ13_RS03735	COG0395	ABC-type sugar transport system, permease component
APQ13_RS03740	COG1175	transmembrane transport
APQ13_RS03745	COG1653	transport
APQ13_RS03750	COG3345	alpha-galactosidase
APQ13_RS03765	COG2801	Transposase and inactivated derivatives
APQ13_RS03770	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
APQ13_RS03770	COG0646	methionine synthase
APQ13_RS03775	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APQ13_RS03780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APQ13_RS03780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APQ13_RS03780	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APQ13_RS03785	COG1105	Belongs to the carbohydrate kinase PfkB family
APQ13_RS03790	COG1349	DNA-binding transcription factor activity
APQ13_RS03795	COG0492	ferredoxin-NADP+ reductase activity
APQ13_RS03800	COG0336	Belongs to the RNA methyltransferase TrmD family
APQ13_RS03805	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APQ13_RS03810	COG1837	Belongs to the UPF0109 family
APQ13_RS03815	COG0228	four-way junction DNA binding
APQ13_RS03820	COG0577	efflux transmembrane transporter activity
APQ13_RS03825	COG1136	(ABC) transporter
APQ13_RS03835	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APQ13_RS03840	COG0505	Belongs to the CarA family
APQ13_RS03845	COG0540	Belongs to the ATCase OTCase family
APQ13_RS03855	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
APQ13_RS03865	COG0564	pseudouridine synthase activity
APQ13_RS03870	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APQ13_RS03875	COG0583	DNA-binding transcription factor activity
APQ13_RS03880	COG2816	NAD+ diphosphatase activity
APQ13_RS03890	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APQ13_RS03900	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APQ13_RS03920	COG0301	tRNA thio-modification
APQ13_RS03925	COG1104	cysteine desulfurase activity
APQ13_RS03935	COG0285	dihydrofolate synthase activity
APQ13_RS03940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APQ13_RS03945	COG0656	L-ascorbic acid biosynthetic process
APQ13_RS03950	COG3942	CHAP domain
APQ13_RS03965	COG0463	Glycosyl transferase, family 2
APQ13_RS03975	COG1368	sulfuric ester hydrolase activity
APQ13_RS04010	COG1091	dTDP-4-dehydrorhamnose reductase activity
APQ13_RS04015	COG2151	metal-sulfur cluster biosynthetic enzyme
APQ13_RS04020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APQ13_RS04025	COG0358	DNA primase activity
APQ13_RS04035	COG1970	mechanosensitive ion channel activity
APQ13_RS04045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APQ13_RS04055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APQ13_RS04075	COG0556	nucleotide-excision repair
APQ13_RS04090	COG1126	abc transporter atp-binding protein
APQ13_RS04095	COG0488	(ABC) transporter
APQ13_RS04105	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APQ13_RS04160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APQ13_RS04170	COG0077	Prephenate dehydratase
APQ13_RS04175	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APQ13_RS04180	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
APQ13_RS04185	COG3679	Belongs to the UPF0342 family
APQ13_RS04190	COG0287	Prephenate dehydrogenase
APQ13_RS04195	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APQ13_RS04200	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APQ13_RS04205	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APQ13_RS04210	COG0710	3-dehydroquinate dehydratase activity
APQ13_RS04215	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
APQ13_RS04220	COG1368	sulfuric ester hydrolase activity
APQ13_RS04240	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
APQ13_RS04265	COG0366	Alpha amylase catalytic
APQ13_RS04265	COG5263	repeat protein
APQ13_RS04275	COG1914	H( )-stimulated, divalent metal cation uptake system
APQ13_RS04280	COG4443	Transcriptional Coactivator p15 (PC4)
APQ13_RS04295	COG0450	alkyl hydroperoxide reductase
APQ13_RS04300	COG0826	peptidase U32
APQ13_RS04325	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APQ13_RS04330	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
APQ13_RS04340	COG3091	SprT-like family
APQ13_RS04345	COG2183	response to ionizing radiation
APQ13_RS04355	COG0701	Predicted permease
APQ13_RS04360	COG3689	TIGRFAM TIGR03943 family protein
APQ13_RS04365	COG0477	Major facilitator Superfamily
APQ13_RS04370	COG0552	protein localization to endoplasmic reticulum
APQ13_RS04375	COG0561	phosphatase activity
APQ13_RS04380	COG0561	phosphatase activity
APQ13_RS04425	COG1131	(ABC) transporter
APQ13_RS04435	COG0604	alcohol dehydrogenase
APQ13_RS04450	COG0584	glycerophosphoryl diester phosphodiesterase
APQ13_RS04470	COG1078	dGTPase activity
APQ13_RS04480	COG2348	transferase activity, transferring amino-acyl groups
APQ13_RS04490	COG0149	triose-phosphate isomerase activity
APQ13_RS04495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APQ13_RS04500	COG0772	Belongs to the SEDS family
APQ13_RS04505	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
APQ13_RS04525	COG3859	Proton-coupled thiamine transporter YuaJ
APQ13_RS04540	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APQ13_RS04550	COG0588	phosphoglycerate mutase activity
APQ13_RS04555	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APQ13_RS04560	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APQ13_RS04565	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APQ13_RS04570	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
APQ13_RS04590	COG2195	Cleaves the N-terminal amino acid of tripeptides
APQ13_RS04625	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
APQ13_RS04640	COG0656	L-ascorbic acid biosynthetic process
APQ13_RS04645	COG0656	L-ascorbic acid biosynthetic process
APQ13_RS04650	COG0789	Transcriptional regulator
APQ13_RS04655	COG1012	belongs to the aldehyde dehydrogenase family
APQ13_RS04660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APQ13_RS04665	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APQ13_RS04675	COG0538	isocitrate dehydrogenase activity
APQ13_RS04680	COG0372	Belongs to the citrate synthase family
APQ13_RS04685	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
APQ13_RS04690	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APQ13_RS04695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APQ13_RS04705	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APQ13_RS04710	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APQ13_RS04715	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
APQ13_RS04720	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APQ13_RS04760	COG1131	(ABC) transporter
APQ13_RS04780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APQ13_RS04790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APQ13_RS04795	COG4122	O-methyltransferase activity
APQ13_RS04800	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
APQ13_RS04800	COG0131	Imidazoleglycerol-phosphate dehydratase
APQ13_RS04825	COG3321	synthase
APQ13_RS04825	COG1028	Short-chain dehydrogenase reductase Sdr
APQ13_RS04825	COG0604	alcohol dehydrogenase
APQ13_RS04830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APQ13_RS04840	COG1187	pseudouridine synthase activity
APQ13_RS04850	COG0363	glucosamine-6-phosphate deaminase activity
APQ13_RS04860	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APQ13_RS04885	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APQ13_RS04900	COG0658	competence protein
APQ13_RS04900	COG2333	competence protein COMEC
APQ13_RS04905	COG1596	polysaccharide export
APQ13_RS04905	COG1555	photosystem II stabilization
APQ13_RS04910	COG0204	Acyl-transferase
APQ13_RS04915	COG0726	polysaccharide deacetylase
APQ13_RS04925	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
APQ13_RS04950	COG0513	Belongs to the DEAD box helicase family
APQ13_RS04955	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APQ13_RS04955	COG3064	Membrane
APQ13_RS04965	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
APQ13_RS04985	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APQ13_RS04990	COG0385	Bile acid
APQ13_RS05000	COG1181	Belongs to the D-alanine--D-alanine ligase family
APQ13_RS05005	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APQ13_RS05010	COG0768	penicillin binding
APQ13_RS05015	COG0588	phosphoglycerate mutase activity
APQ13_RS05045	COG0776	regulation of translation
APQ13_RS05055	COG2755	lipolytic protein G-D-S-L family
APQ13_RS05060	COG1307	EDD domain protein, DegV family
APQ13_RS05065	COG0497	DNA recombination
APQ13_RS05070	COG1438	arginine binding
APQ13_RS05075	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
APQ13_RS05085	COG1722	exodeoxyribonuclease VII activity
APQ13_RS05090	COG1570	exodeoxyribonuclease VII activity
APQ13_RS05095	COG3275	phosphorelay sensor kinase activity
APQ13_RS05100	COG3279	Response regulator of the LytR AlgR family
APQ13_RS05105	COG1380	Effector of murein hydrolase LrgA
APQ13_RS05110	COG1346	cytolysis
APQ13_RS05115	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
APQ13_RS05120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APQ13_RS05140	COG1126	abc transporter atp-binding protein
APQ13_RS05145	COG0765	amino acid transport
APQ13_RS05150	COG4703	Protein of unknown function (DUF1797)
APQ13_RS05155	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APQ13_RS05160	COG0542	response to heat
APQ13_RS05180	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APQ13_RS05185	COG3599	regulation of cell shape
APQ13_RS05190	COG2302	S4 RNA-binding domain
APQ13_RS05200	COG1799	cell septum assembly
APQ13_RS05205	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APQ13_RS05215	COG0849	cell division
APQ13_RS05225	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APQ13_RS05230	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APQ13_RS05240	COG1217	gtp-binding protein TYPA
APQ13_RS05245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APQ13_RS05250	COG1940	carbohydrate kinase activity
APQ13_RS05260	COG0783	Belongs to the Dps family
APQ13_RS05270	COG0159	tryptophan synthase activity
APQ13_RS05275	COG0133	tryptophan synthase activity
APQ13_RS05280	COG0135	phosphoribosylanthranilate isomerase activity
APQ13_RS05285	COG0134	indole-3-glycerol-phosphate synthase activity
APQ13_RS05290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APQ13_RS05295	COG0512	Glutamine amidotransferase of anthranilate synthase
APQ13_RS05300	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APQ13_RS05320	COG3804	dihydrodipicolinate reductase
APQ13_RS05330	COG1132	(ABC) transporter
APQ13_RS05335	COG1132	(ABC) transporter
APQ13_RS05345	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APQ13_RS05350	COG4470	Protein conserved in bacteria
APQ13_RS05355	COG0737	Belongs to the 5'-nucleotidase family
APQ13_RS05360	COG3480	Lon protease (S16) C-terminal proteolytic domain
APQ13_RS05365	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APQ13_RS05370	COG0742	ribosomal rna small subunit methyltransferase
APQ13_RS05375	COG4716	Myosin-crossreactive antigen
APQ13_RS05430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APQ13_RS05440	COG0561	phosphatase activity
APQ13_RS05445	COG1349	DNA-binding transcription factor activity
APQ13_RS05490	COG1040	competence protein
APQ13_RS05495	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
APQ13_RS05500	COG1739	Uncharacterized protein family UPF0029
APQ13_RS05520	COG1882	Formate acetyltransferase
APQ13_RS05525	COG1349	DNA-binding transcription factor activity
APQ13_RS05530	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APQ13_RS05535	COG1098	S1 RNA binding domain
APQ13_RS05545	COG2197	response regulator
APQ13_RS05550	COG4585	Histidine kinase
APQ13_RS05570	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APQ13_RS05570	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APQ13_RS05575	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APQ13_RS05580	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APQ13_RS05585	COG1758	RNA polymerase activity
APQ13_RS05590	COG0194	GDP metabolic process
APQ13_RS05595	COG4372	Transposase
APQ13_RS05595	COG1418	mRNA catabolic process
APQ13_RS05600	COG1854	S-ribosylhomocysteine lyase activity
APQ13_RS05610	COG0116	Belongs to the methyltransferase superfamily
APQ13_RS05620	COG3599	regulation of cell shape
APQ13_RS05625	COG4474	Belongs to the UPF0398 family
APQ13_RS05630	COG3331	DNA recombination
APQ13_RS05635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APQ13_RS05640	COG3579	cysteine-type endopeptidase activity
APQ13_RS05645	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
APQ13_RS05650	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
APQ13_RS05655	COG0492	ferredoxin-NADP+ reductase activity
APQ13_RS05665	COG1126	abc transporter atp-binding protein
APQ13_RS05680	COG0513	Belongs to the DEAD box helicase family
APQ13_RS05690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APQ13_RS05695	COG0768	penicillin binding
APQ13_RS05700	COG4839	cell division protein FtsL
APQ13_RS05705	COG0275	rRNA processing
APQ13_RS05710	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APQ13_RS05715	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APQ13_RS05725	COG4224	UPF0291 protein
APQ13_RS05730	COG0751	glycine-tRNA ligase activity
APQ13_RS05735	COG0752	glycyl-tRNA synthetase alpha subunit
APQ13_RS05740	COG1673	EVE domain
APQ13_RS05760	COG1924	4 iron, 4 sulfur cluster binding
APQ13_RS05785	COG1131	(ABC) transporter
APQ13_RS05795	COG0561	phosphatase activity
APQ13_RS05805	COG2217	Heavy metal translocating P-type atpase
APQ13_RS05820	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APQ13_RS05825	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APQ13_RS05835	COG2740	Nucleic-acid-binding protein implicated in transcription termination
APQ13_RS05840	COG0195	Participates in both transcription termination and antitermination
APQ13_RS05845	COG0779	Required for maturation of 30S ribosomal subunits
APQ13_RS05855	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APQ13_RS05865	COG4473	ABC transporter
APQ13_RS05870	COG1131	(ABC) transporter
APQ13_RS05875	COG0537	adenosine 5'-monophosphoramidase activity
APQ13_RS05885	COG1316	TRANSCRIPTIONal
APQ13_RS05890	COG0802	atpase or kinase
APQ13_RS05895	COG2252	PERMEase
APQ13_RS05905	COG0561	phosphatase activity
APQ13_RS05920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APQ13_RS05925	COG1882	Formate acetyltransferase
APQ13_RS05935	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
APQ13_RS05950	COG2936	dipeptidyl-peptidase activity
APQ13_RS05955	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APQ13_RS05965	COG2081	HI0933 family
APQ13_RS05985	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APQ13_RS05990	COG0456	acetyltransferase
APQ13_RS05995	COG1214	PFAM Peptidase M22, glycoprotease
APQ13_RS06005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APQ13_RS06010	COG0667	Aldo Keto reductase
APQ13_RS06025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APQ13_RS06040	COG2226	methyltransferase
APQ13_RS06060	COG5503	Protein of unknown function (DUF1447)
APQ13_RS06070	COG3942	CHAP domain
APQ13_RS06075	COG0493	'glutamate synthase
APQ13_RS06080	COG0067	glutamate synthase
APQ13_RS06080	COG0070	glutamate synthase
APQ13_RS06080	COG0069	glutamate synthase activity
APQ13_RS06085	COG0174	glutamine synthetase
APQ13_RS06090	COG0789	Transcriptional regulator
APQ13_RS06100	COG0126	phosphoglycerate kinase activity
APQ13_RS06110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APQ13_RS06115	COG0049	tRNA binding
APQ13_RS06120	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APQ13_RS06125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APQ13_RS06150	COG1162	GTPase activity
APQ13_RS06170	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
APQ13_RS06205	COG0084	hydrolase, TatD family'
APQ13_RS06210	COG0230	Belongs to the bacterial ribosomal protein bL34 family
APQ13_RS06225	COG0706	membrane insertase activity
APQ13_RS06230	COG0594	ribonuclease P activity
APQ13_RS06235	COG0165	Argininosuccinate lyase
APQ13_RS06240	COG0137	argininosuccinate synthase activity
APQ13_RS06255	COG1827	regulation of RNA biosynthetic process
APQ13_RS06260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APQ13_RS06285	COG0756	dUTP diphosphatase activity
APQ13_RS06290	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
APQ13_RS06295	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APQ13_RS06300	COG0705	Rhomboid family
APQ13_RS06300	COG0457	Tetratricopeptide repeat
APQ13_RS06305	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APQ13_RS06310	COG1473	amidohydrolase
APQ13_RS06315	COG2171	N-acyltransferase activity
APQ13_RS06330	COG3732	PTS system glucitol sorbitol-specific
APQ13_RS06335	COG3730	PTS system glucitol sorbitol-specific
APQ13_RS06345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APQ13_RS06345	COG3711	transcriptional antiterminator
APQ13_RS06355	COG0166	Belongs to the GPI family
APQ13_RS06375	COG1234	tRNA 3'-trailer cleavage
APQ13_RS06390	COG0343	queuine tRNA-ribosyltransferase activity
APQ13_RS06400	COG1832	CoA-binding protein
APQ13_RS06405	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APQ13_RS06405	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APQ13_RS06420	COG0583	DNA-binding transcription factor activity
APQ13_RS06450	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APQ13_RS06480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APQ13_RS06480	COG3711	transcriptional antiterminator
APQ13_RS06495	COG2274	protein secretion by the type I secretion system
APQ13_RS06530	COG3623	hexulose-6-phosphate isomerase
APQ13_RS06540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APQ13_RS06555	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APQ13_RS06560	COG2918	glutathione biosynthetic process
APQ13_RS06560	COG1181	Belongs to the D-alanine--D-alanine ligase family
APQ13_RS06570	COG2957	Belongs to the agmatine deiminase family
APQ13_RS06575	COG0531	amino acid
APQ13_RS06580	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APQ13_RS06595	COG4608	Belongs to the ABC transporter superfamily
APQ13_RS06600	COG0444	Belongs to the ABC transporter superfamily
APQ13_RS06605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APQ13_RS06610	COG0601	transmembrane transport
APQ13_RS06615	COG4166	transmembrane transport
APQ13_RS06630	COG0719	Fe-S assembly protein
APQ13_RS06640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APQ13_RS06645	COG0719	Fe-S assembly protein
APQ13_RS06655	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APQ13_RS06660	COG4862	establishment of competence for transformation
APQ13_RS06665	COG1968	undecaprenyl-diphosphatase activity
APQ13_RS06675	COG0765	amino acid transport
APQ13_RS06680	COG1126	abc transporter atp-binding protein
APQ13_RS06700	COG1309	transcriptional regulator
APQ13_RS06710	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APQ13_RS06715	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APQ13_RS06720	COG0440	acetolactate synthase activity
APQ13_RS06725	COG0028	Belongs to the TPP enzyme family
APQ13_RS06760	COG0582	viral genome integration into host DNA
APQ13_RS06850	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
APQ13_RS06855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APQ13_RS06865	COG0803	Belongs to the bacterial solute-binding protein 9 family
APQ13_RS06880	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
APQ13_RS06885	COG0431	NADPH-dependent FMN reductase
APQ13_RS06885	COG3976	FMN-binding domain protein
APQ13_RS06885	COG1053	succinate dehydrogenase
APQ13_RS06890	COG3976	FMN-binding domain protein
APQ13_RS06890	COG1053	succinate dehydrogenase
APQ13_RS06890	COG0431	NADPH-dependent FMN reductase
APQ13_RS06900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APQ13_RS06920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
APQ13_RS06925	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APQ13_RS06930	COG1476	TRANSCRIPTIONal
APQ13_RS06950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APQ13_RS06970	COG5504	Zn-dependent protease
APQ13_RS06975	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
APQ13_RS06980	COG0215	cysteine-tRNA ligase activity
APQ13_RS06985	COG1045	serine acetyltransferase
APQ13_RS06995	COG1185	polyribonucleotide nucleotidyltransferase activity
APQ13_RS07000	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APQ13_RS07005	COG1454	alcohol dehydrogenase
APQ13_RS07005	COG1012	belongs to the aldehyde dehydrogenase family
APQ13_RS07015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APQ13_RS07020	COG0242	peptide deformylase activity
APQ13_RS07035	COG2140	Oxalate decarboxylase
APQ13_RS07040	COG0679	Auxin Efflux Carrier
APQ13_RS07045	COG0281	malic enzyme
APQ13_RS07055	COG0583	DNA-binding transcription factor activity
APQ13_RS07060	COG1309	transcriptional regulator
APQ13_RS07065	COG0477	Major facilitator Superfamily
APQ13_RS07070	COG1473	amidohydrolase
APQ13_RS07075	COG0095	Lipoate-protein ligase
APQ13_RS07090	COG0508	dehydrogenase complex catalyzes the overall conversion of
APQ13_RS07090	COG0022	dehydrogenase e1 component
APQ13_RS07095	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
APQ13_RS07100	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
APQ13_RS07105	COG1846	Transcriptional regulator
APQ13_RS07110	COG2176	DNA-directed DNA polymerase activity
APQ13_RS07115	COG0534	Mate efflux family protein
APQ13_RS07120	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APQ13_RS07140	COG3684	Belongs to the aldolase LacD family
APQ13_RS07145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APQ13_RS07145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APQ13_RS07145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APQ13_RS07150	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APQ13_RS07150	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APQ13_RS07150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APQ13_RS07155	COG1105	Belongs to the carbohydrate kinase PfkB family
APQ13_RS07170	COG0191	fructose-bisphosphate aldolase activity
APQ13_RS07180	COG0504	CTP synthase activity
APQ13_RS07185	COG3343	RNA polymerase activity
APQ13_RS07195	COG0544	peptidyl-prolyl cis-trans isomerase activity
APQ13_RS07205	COG0668	transmembrane transport
APQ13_RS07210	COG4475	Protein of unknown function (DUF436)
APQ13_RS07215	COG4720	Psort location CytoplasmicMembrane, score
APQ13_RS07220	COG0351	phosphomethylpyrimidine kinase
APQ13_RS07225	COG0101	tRNA pseudouridine synthase activity
APQ13_RS07230	COG0484	heat shock protein binding
APQ13_RS07235	COG0443	Heat shock 70 kDa protein
APQ13_RS07240	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APQ13_RS07245	COG1420	regulation of RNA biosynthetic process
APQ13_RS07250	COG1621	beta-fructofuranosidase activity
APQ13_RS07255	COG1621	beta-fructofuranosidase activity
APQ13_RS07255	COG3583	domain protein
APQ13_RS07255	COG5492	domain, Protein
APQ13_RS07260	COG1705	Flagellar rod assembly protein muramidase FlgJ
APQ13_RS07275	COG2848	UPF0210 protein
APQ13_RS07280	COG3830	Belongs to the UPF0237 family
APQ13_RS07285	COG0534	Mate efflux family protein
APQ13_RS07305	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APQ13_RS07310	COG2255	four-way junction helicase activity
APQ13_RS07330	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APQ13_RS07350	COG1794	racemase activity, acting on amino acids and derivatives
APQ13_RS07365	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APQ13_RS07375	COG0151	Belongs to the GarS family
APQ13_RS07380	COG0457	Tetratricopeptide repeat
APQ13_RS07405	COG0138	bifunctional purine biosynthesis protein purh
APQ13_RS07415	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APQ13_RS07420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APQ13_RS07425	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APQ13_RS07435	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APQ13_RS07440	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
APQ13_RS07445	COG2274	protein secretion by the type I secretion system
APQ13_RS07450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APQ13_RS07455	COG0416	fatty acid biosynthetic process
APQ13_RS07460	COG1381	Involved in DNA repair and RecF pathway recombination
APQ13_RS07465	COG0436	Aminotransferase
APQ13_RS07470	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APQ13_RS07475	COG3942	CHAP domain
APQ13_RS07485	COG1792	Involved in formation and maintenance of cell shape
APQ13_RS07595	COG0531	amino acid
APQ13_RS07600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APQ13_RS07605	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
APQ13_RS07610	COG0037	tRNA processing
APQ13_RS07630	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
APQ13_RS07635	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APQ13_RS07640	COG0193	aminoacyl-tRNA hydrolase activity
APQ13_RS07645	COG0012	GTP binding
APQ13_RS07655	COG0592	DNA-directed DNA polymerase activity
APQ13_RS07660	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APQ13_RS07665	COG1475	DNA binding
APQ13_RS07670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APQ13_RS07675	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APQ13_RS07705	COG0488	(ABC) transporter
APQ13_RS07710	COG0180	Tryptophanyl-tRNA synthetase
APQ13_RS07715	COG0517	IMP dehydrogenase activity
APQ13_RS07715	COG0516	GMP reductase activity
APQ13_RS07720	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APQ13_RS07735	COG0612	Peptidase, M16
APQ13_RS07745	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APQ13_RS07750	COG1122	ATPase activity
APQ13_RS07755	COG1122	ATPase activity
APQ13_RS07760	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APQ13_RS07770	COG0741	lytic transglycosylase activity
APQ13_RS07775	COG0482	sulfurtransferase activity
APQ13_RS07785	COG0445	tRNA wobble uridine modification
APQ13_RS07795	COG0359	binds to the 23S rRNA
APQ13_RS07800	COG0305	Participates in initiation and elongation during chromosome replication
APQ13_RS07810	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APQ13_RS07830	COG2151	metal-sulfur cluster biosynthetic enzyme
APQ13_RS07835	COG0129	dihydroxy-acid dehydratase activity
APQ13_RS07840	COG1012	belongs to the aldehyde dehydrogenase family
APQ13_RS07850	COG1733	regulation of RNA biosynthetic process
APQ13_RS07865	COG2094	Belongs to the DNA glycosylase MPG family
APQ13_RS07890	COG1028	Short-chain dehydrogenase reductase Sdr
APQ13_RS07895	COG0789	Transcriptional regulator
APQ13_RS07915	COG2814	Major facilitator Superfamily
APQ13_RS07920	COG0640	Transcriptional regulator
APQ13_RS07935	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APQ13_RS07940	COG0333	Belongs to the bacterial ribosomal protein bL32 family
APQ13_RS07945	COG0531	amino acid
APQ13_RS07950	COG0124	histidyl-tRNA synthetase
APQ13_RS07955	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APQ13_RS07960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
APQ13_RS07965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
APQ13_RS07970	COG0018	arginyl-trna synthetase
APQ13_RS07990	COG1438	arginine binding
APQ13_RS08000	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APQ13_RS08010	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
APQ13_RS08015	COG0632	four-way junction helicase activity
APQ13_RS08020	COG0519	Catalyzes the synthesis of GMP from XMP
APQ13_RS08025	COG1058	Belongs to the CinA family
APQ13_RS08025	COG1546	Belongs to the CinA family
APQ13_RS08030	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APQ13_RS08035	COG1393	Belongs to the ArsC family
APQ13_RS08055	COG4472	Bacterial protein of unknown function (DUF965)
APQ13_RS08060	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APQ13_RS08065	COG3906	Belongs to the UPF0473 family
APQ13_RS08100	COG3022	response to hydroperoxide
APQ13_RS08105	COG0428	transporter
APQ13_RS08110	COG0463	Glycosyl transferase, family 2
APQ13_RS08120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APQ13_RS08130	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APQ13_RS08140	COG0583	DNA-binding transcription factor activity
APQ13_RS08145	COG2855	membrane
APQ13_RS08170	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
APQ13_RS08190	COG1136	(ABC) transporter
APQ13_RS08190	COG0577	efflux transmembrane transporter activity
APQ13_RS08195	COG1250	3-hydroxyacyl-CoA dehydrogenase
APQ13_RS08220	COG0577	efflux transmembrane transporter activity
APQ13_RS08220	COG1136	(ABC) transporter
APQ13_RS08240	COG2217	Heavy metal translocating P-type atpase
APQ13_RS08255	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APQ13_RS08275	COG2264	protein methyltransferase activity
APQ13_RS08280	COG1385	rRNA (uridine-N3-)-methyltransferase activity
APQ13_RS08285	COG1609	Transcriptional regulator
APQ13_RS08295	COG1263	PTS System
APQ13_RS08295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APQ13_RS08295	COG2190	(PTS) system
APQ13_RS08310	COG1490	D-aminoacyl-tRNA deacylase activity
APQ13_RS08315	COG5297	Belongs to the glycosyl hydrolase family 6
APQ13_RS08330	COG2188	Transcriptional regulator
APQ13_RS08335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APQ13_RS08335	COG1263	PTS System
APQ13_RS08340	COG0366	Alpha amylase catalytic
APQ13_RS08345	COG3590	peptidase
APQ13_RS08350	COG1619	proteins homologs of microcin C7 resistance protein MccF
APQ13_RS08365	COG0052	Belongs to the universal ribosomal protein uS2 family
APQ13_RS08370	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APQ13_RS08375	COG4463	regulation of RNA biosynthetic process
APQ13_RS08380	COG0542	response to heat
APQ13_RS08385	COG1621	beta-fructofuranosidase activity
APQ13_RS08395	COG0051	transcription antitermination factor activity, RNA binding
APQ13_RS08400	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APQ13_RS08410	COG0089	rRNA binding
APQ13_RS08415	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APQ13_RS08425	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APQ13_RS08430	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APQ13_RS08435	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APQ13_RS08440	COG0255	Belongs to the universal ribosomal protein uL29 family
APQ13_RS08445	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APQ13_RS08450	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APQ13_RS08455	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APQ13_RS08460	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APQ13_RS08465	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APQ13_RS08470	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APQ13_RS08475	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APQ13_RS08485	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APQ13_RS08490	COG1841	ribosomal large subunit assembly
APQ13_RS08495	COG0200	Binds to the 23S rRNA
APQ13_RS08500	COG0201	protein transport
APQ13_RS08505	COG0563	adenylate kinase activity
APQ13_RS08510	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APQ13_RS08520	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APQ13_RS08525	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APQ13_RS08530	COG0202	RNA polymerase activity
APQ13_RS08535	COG0203	ribosomal protein L17
APQ13_RS08575	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
APQ13_RS08585	COG1121	(ABC) transporter
APQ13_RS08590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APQ13_RS08595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APQ13_RS08600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APQ13_RS08605	COG0085	RNA polymerase activity
APQ13_RS08610	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APQ13_RS08620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APQ13_RS08625	COG1459	type II secretion system
APQ13_RS08655	COG0827	DNA restriction-modification system
APQ13_RS08660	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APQ13_RS08680	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APQ13_RS08685	COG1363	Peptidase, m42
APQ13_RS08695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APQ13_RS08700	COG0072	phenylalanine-tRNA ligase activity
APQ13_RS08700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APQ13_RS08705	COG1846	Transcriptional regulator
APQ13_RS08725	COG4585	Histidine kinase
APQ13_RS08730	COG2197	response regulator
APQ13_RS08750	COG3715	PTS system
APQ13_RS08755	COG3716	PTS system mannose fructose sorbose family IID component
APQ13_RS08765	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APQ13_RS08770	COG0459	protein refolding
APQ13_RS08780	COG0564	pseudouridine synthase activity
APQ13_RS08785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APQ13_RS08815	COG0495	leucyl-tRNA aminoacylation
APQ13_RS08820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APQ13_RS08825	COG1464	Belongs to the NlpA lipoprotein family
APQ13_RS08830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APQ13_RS08835	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APQ13_RS08845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APQ13_RS08855	COG4720	Psort location CytoplasmicMembrane, score
APQ13_RS08860	COG1122	ATPase activity
APQ13_RS08870	COG0357	Ribosomal RNA small subunit methyltransferase G
APQ13_RS08875	COG1704	LemA family
APQ13_RS08880	COG0501	Belongs to the peptidase M48B family
APQ13_RS08885	COG4591	ABC-type transport system involved in lipoprotein release permease component
APQ13_RS08890	COG1136	(ABC) transporter
APQ13_RS08905	COG0745	RESPONSE REGULATOR receiver
APQ13_RS08910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APQ13_RS08920	COG1484	DNA-dependent DNA replication
APQ13_RS08925	COG1160	GTP binding
APQ13_RS08935	COG0586	Pfam SNARE associated Golgi protein
APQ13_RS08945	COG3290	protein histidine kinase activity
APQ13_RS09015	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APQ13_RS09035	COG2274	protein secretion by the type I secretion system
APQ13_RS09040	COG3716	PTS system mannose fructose sorbose family IID component
APQ13_RS09045	COG3715	PTS system
APQ13_RS09060	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APQ13_RS09065	COG0681	Belongs to the peptidase S26 family
APQ13_RS09070	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APQ13_RS09085	COG1193	negative regulation of DNA recombination
APQ13_RS09090	COG3118	belongs to the thioredoxin family
APQ13_RS09095	COG1063	alcohol dehydrogenase
APQ13_RS09100	COG1194	a g-specific adenine glycosylase
APQ13_RS09115	COG0360	Binds together with S18 to 16S ribosomal RNA
APQ13_RS09120	COG0629	single-stranded DNA binding
APQ13_RS09125	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APQ13_RS09160	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APQ13_RS09165	COG0006	proline dipeptidase activity
APQ13_RS09170	COG2131	deaminase
APQ13_RS09175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APQ13_RS09180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APQ13_RS09190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APQ13_RS09195	COG1609	Transcriptional regulator
APQ13_RS09200	COG1621	beta-fructofuranosidase activity
APQ13_RS09205	COG1263	PTS System
APQ13_RS09205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APQ13_RS09205	COG2190	(PTS) system
APQ13_RS09210	COG1940	carbohydrate kinase activity
APQ13_RS09215	COG1482	cell wall glycoprotein biosynthetic process
APQ13_RS09220	COG0653	protein targeting
APQ13_RS09225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APQ13_RS09230	COG0736	holo-[acyl-carrier-protein] synthase activity
APQ13_RS09235	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APQ13_RS09240	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APQ13_RS09250	COG0252	asparaginase activity
APQ13_RS09255	COG0561	phosphatase activity
APQ13_RS09265	COG1268	BioY protein
APQ13_RS09270	COG0436	Aminotransferase
APQ13_RS09275	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
APQ13_RS09280	COG1335	isochorismatase
APQ13_RS09285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APQ13_RS09290	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APQ13_RS09295	COG0154	amidase activity
APQ13_RS09300	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APQ13_RS09305	COG0697	spore germination
APQ13_RS09310	COG1819	glycosyl
APQ13_RS09315	COG1309	transcriptional regulator
APQ13_RS09330	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
APQ13_RS09335	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
APQ13_RS09340	COG1534	Rna-binding protein
APQ13_RS09345	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APQ13_RS09350	COG1713	HD superfamily hydrolase involved in NAD metabolism
APQ13_RS09355	COG0799	negative regulation of ribosome biogenesis
APQ13_RS09360	COG2226	methyltransferase
APQ13_RS09375	COG1323	Belongs to the UPF0348 family
APQ13_RS09380	COG0789	Transcriptional regulator
APQ13_RS09385	COG0217	transcriptional regulatory protein
APQ13_RS09395	COG1862	Preprotein translocase
APQ13_RS09400	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APQ13_RS09405	COG4589	Belongs to the CDS family
APQ13_RS09415	COG0442	prolyl-tRNA aminoacylation
APQ13_RS09470	COG3557	Belongs to the UPF0374 family
APQ13_RS09475	COG2137	regulation of response to DNA damage stimulus
APQ13_RS09480	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APQ13_RS09485	COG1780	Probably involved in ribonucleotide reductase function
APQ13_RS09530	COG0525	valine-tRNA ligase activity
APQ13_RS09535	COG0232	Belongs to the dGTPase family. Type 2 subfamily
APQ13_RS09610	COG0527	aspartate kinase activity
APQ13_RS09615	COG0546	phosphoglycolate phosphatase activity
APQ13_RS09620	COG1024	Enoyl-CoA hydratase
APQ13_RS09625	COG1846	Transcriptional regulator
APQ13_RS09630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APQ13_RS09645	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
APQ13_RS09650	COG1028	Short-chain dehydrogenase reductase Sdr
APQ13_RS09655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APQ13_RS09665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APQ13_RS09670	COG0439	Biotin carboxylase
APQ13_RS09685	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APQ13_RS09695	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity