locus-tag	class	description
SMUNN2025_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SMUNN2025_RS00010	COG0592	DNA-directed DNA polymerase activity
SMUNN2025_RS00020	COG0012	GTP binding
SMUNN2025_RS00025	COG0193	aminoacyl-tRNA hydrolase activity
SMUNN2025_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SMUNN2025_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SMUNN2025_RS00055	COG0037	tRNA processing
SMUNN2025_RS00060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SMUNN2025_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMUNN2025_RS00070	COG0531	amino acid
SMUNN2025_RS00180	COG1792	Involved in formation and maintenance of cell shape
SMUNN2025_RS00190	COG3942	CHAP domain
SMUNN2025_RS00195	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMUNN2025_RS00200	COG0436	Aminotransferase
SMUNN2025_RS00205	COG1381	Involved in DNA repair and RecF pathway recombination
SMUNN2025_RS00210	COG0416	fatty acid biosynthetic process
SMUNN2025_RS00215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMUNN2025_RS00220	COG2274	protein secretion by the type I secretion system
SMUNN2025_RS00225	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SMUNN2025_RS00230	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMUNN2025_RS00240	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SMUNN2025_RS00245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SMUNN2025_RS00250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SMUNN2025_RS00260	COG0138	bifunctional purine biosynthesis protein purh
SMUNN2025_RS00300	COG0151	Belongs to the GarS family
SMUNN2025_RS00310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SMUNN2025_RS00325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMUNN2025_RS00345	COG2255	four-way junction helicase activity
SMUNN2025_RS00350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMUNN2025_RS00370	COG0534	Mate efflux family protein
SMUNN2025_RS00375	COG3830	Belongs to the UPF0237 family
SMUNN2025_RS00380	COG2848	UPF0210 protein
SMUNN2025_RS00395	COG1705	Flagellar rod assembly protein muramidase FlgJ
SMUNN2025_RS00400	COG5492	domain, Protein
SMUNN2025_RS00400	COG3583	domain protein
SMUNN2025_RS00400	COG1621	beta-fructofuranosidase activity
SMUNN2025_RS00410	COG1420	regulation of RNA biosynthetic process
SMUNN2025_RS00415	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SMUNN2025_RS00420	COG0443	Heat shock 70 kDa protein
SMUNN2025_RS00425	COG0484	heat shock protein binding
SMUNN2025_RS00430	COG0101	tRNA pseudouridine synthase activity
SMUNN2025_RS00435	COG0351	phosphomethylpyrimidine kinase
SMUNN2025_RS00440	COG4720	Psort location CytoplasmicMembrane, score
SMUNN2025_RS00445	COG4475	Protein of unknown function (DUF436)
SMUNN2025_RS00450	COG0668	transmembrane transport
SMUNN2025_RS00460	COG0544	peptidyl-prolyl cis-trans isomerase activity
SMUNN2025_RS00470	COG2226	methyltransferase
SMUNN2025_RS00475	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SMUNN2025_RS00480	COG1854	S-ribosylhomocysteine lyase activity
SMUNN2025_RS00485	COG0697	spore germination
SMUNN2025_RS00490	COG1959	2 iron, 2 sulfur cluster binding
SMUNN2025_RS00495	COG2223	nitrite transmembrane transporter activity
SMUNN2025_RS00520	COG3343	RNA polymerase activity
SMUNN2025_RS00525	COG0504	CTP synthase activity
SMUNN2025_RS00545	COG0191	fructose-bisphosphate aldolase activity
SMUNN2025_RS00555	COG3715	PTS system
SMUNN2025_RS00595	COG1396	sequence-specific DNA binding
SMUNN2025_RS00605	COG1105	Belongs to the carbohydrate kinase PfkB family
SMUNN2025_RS00610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMUNN2025_RS00610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMUNN2025_RS00610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUNN2025_RS00615	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMUNN2025_RS00615	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMUNN2025_RS00615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUNN2025_RS00620	COG3684	Belongs to the aldolase LacD family
SMUNN2025_RS00640	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SMUNN2025_RS00645	COG0534	Mate efflux family protein
SMUNN2025_RS00650	COG2176	DNA-directed DNA polymerase activity
SMUNN2025_RS00655	COG1846	Transcriptional regulator
SMUNN2025_RS00660	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SMUNN2025_RS00665	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SMUNN2025_RS00670	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMUNN2025_RS00670	COG0022	dehydrogenase e1 component
SMUNN2025_RS00685	COG0095	Lipoate-protein ligase
SMUNN2025_RS00690	COG1473	amidohydrolase
SMUNN2025_RS00695	COG0477	Major facilitator Superfamily
SMUNN2025_RS00700	COG1309	transcriptional regulator
SMUNN2025_RS00705	COG0242	peptide deformylase activity
SMUNN2025_RS00710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMUNN2025_RS00720	COG1454	alcohol dehydrogenase
SMUNN2025_RS00720	COG1012	belongs to the aldehyde dehydrogenase family
SMUNN2025_RS00725	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SMUNN2025_RS00730	COG1185	polyribonucleotide nucleotidyltransferase activity
SMUNN2025_RS00740	COG1045	serine acetyltransferase
SMUNN2025_RS00745	COG0215	cysteine-tRNA ligase activity
SMUNN2025_RS00750	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SMUNN2025_RS00755	COG5504	Zn-dependent protease
SMUNN2025_RS00775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMUNN2025_RS00795	COG1476	TRANSCRIPTIONal
SMUNN2025_RS00800	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SMUNN2025_RS00805	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SMUNN2025_RS00825	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMUNN2025_RS00835	COG1053	succinate dehydrogenase
SMUNN2025_RS00835	COG3976	FMN-binding domain protein
SMUNN2025_RS00835	COG0431	NADPH-dependent FMN reductase
SMUNN2025_RS00840	COG0431	NADPH-dependent FMN reductase
SMUNN2025_RS00840	COG1053	succinate dehydrogenase
SMUNN2025_RS00840	COG3976	FMN-binding domain protein
SMUNN2025_RS00845	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SMUNN2025_RS00860	COG0803	Belongs to the bacterial solute-binding protein 9 family
SMUNN2025_RS00870	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SMUNN2025_RS00875	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SMUNN2025_RS00915	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SMUNN2025_RS00925	COG1121	(ABC) transporter
SMUNN2025_RS00930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SMUNN2025_RS00935	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SMUNN2025_RS00940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMUNN2025_RS00945	COG0085	RNA polymerase activity
SMUNN2025_RS00950	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SMUNN2025_RS00960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SMUNN2025_RS00965	COG1459	type II secretion system
SMUNN2025_RS00995	COG0827	DNA restriction-modification system
SMUNN2025_RS01000	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SMUNN2025_RS01020	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SMUNN2025_RS01025	COG1363	Peptidase, m42
SMUNN2025_RS01035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMUNN2025_RS01040	COG0072	phenylalanine-tRNA ligase activity
SMUNN2025_RS01040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMUNN2025_RS01045	COG1846	Transcriptional regulator
SMUNN2025_RS01065	COG4585	Histidine kinase
SMUNN2025_RS01070	COG2197	response regulator
SMUNN2025_RS01090	COG3715	PTS system
SMUNN2025_RS01095	COG3716	PTS system mannose fructose sorbose family IID component
SMUNN2025_RS01105	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SMUNN2025_RS01110	COG0459	protein refolding
SMUNN2025_RS01120	COG0564	pseudouridine synthase activity
SMUNN2025_RS01125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMUNN2025_RS01155	COG0495	leucyl-tRNA aminoacylation
SMUNN2025_RS01160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUNN2025_RS01165	COG1464	Belongs to the NlpA lipoprotein family
SMUNN2025_RS01170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMUNN2025_RS01175	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SMUNN2025_RS01185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMUNN2025_RS01195	COG4720	Psort location CytoplasmicMembrane, score
SMUNN2025_RS01200	COG1122	ATPase activity
SMUNN2025_RS01210	COG0357	Ribosomal RNA small subunit methyltransferase G
SMUNN2025_RS01215	COG1704	LemA family
SMUNN2025_RS01220	COG0501	Belongs to the peptidase M48B family
SMUNN2025_RS01230	COG1136	(ABC) transporter
SMUNN2025_RS01245	COG0745	RESPONSE REGULATOR receiver
SMUNN2025_RS01250	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SMUNN2025_RS01260	COG1484	DNA-dependent DNA replication
SMUNN2025_RS01265	COG1160	GTP binding
SMUNN2025_RS01275	COG0586	Pfam SNARE associated Golgi protein
SMUNN2025_RS01285	COG3290	protein histidine kinase activity
SMUNN2025_RS01340	COG2274	protein secretion by the type I secretion system
SMUNN2025_RS01345	COG2274	protein secretion by the type I secretion system
SMUNN2025_RS01375	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SMUNN2025_RS01395	COG2274	protein secretion by the type I secretion system
SMUNN2025_RS01400	COG3716	PTS system mannose fructose sorbose family IID component
SMUNN2025_RS01405	COG3715	PTS system
SMUNN2025_RS01420	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SMUNN2025_RS01425	COG0681	Belongs to the peptidase S26 family
SMUNN2025_RS01430	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SMUNN2025_RS01450	COG1193	negative regulation of DNA recombination
SMUNN2025_RS01455	COG3118	belongs to the thioredoxin family
SMUNN2025_RS01460	COG1063	alcohol dehydrogenase
SMUNN2025_RS01465	COG1194	a g-specific adenine glycosylase
SMUNN2025_RS01480	COG0360	Binds together with S18 to 16S ribosomal RNA
SMUNN2025_RS01485	COG0629	single-stranded DNA binding
SMUNN2025_RS01490	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SMUNN2025_RS01525	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SMUNN2025_RS01530	COG0006	proline dipeptidase activity
SMUNN2025_RS01535	COG2131	deaminase
SMUNN2025_RS01540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMUNN2025_RS01545	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SMUNN2025_RS01555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMUNN2025_RS01560	COG1609	Transcriptional regulator
SMUNN2025_RS01565	COG1621	beta-fructofuranosidase activity
SMUNN2025_RS01570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMUNN2025_RS01570	COG2190	(PTS) system
SMUNN2025_RS01570	COG1263	PTS System
SMUNN2025_RS01575	COG1940	carbohydrate kinase activity
SMUNN2025_RS01580	COG1482	cell wall glycoprotein biosynthetic process
SMUNN2025_RS01585	COG0653	protein targeting
SMUNN2025_RS01590	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SMUNN2025_RS01595	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SMUNN2025_RS01600	COG0736	holo-[acyl-carrier-protein] synthase activity
SMUNN2025_RS01605	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SMUNN2025_RS01610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SMUNN2025_RS01620	COG0252	asparaginase activity
SMUNN2025_RS01625	COG0561	phosphatase activity
SMUNN2025_RS01635	COG1268	BioY protein
SMUNN2025_RS01640	COG0436	Aminotransferase
SMUNN2025_RS01645	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SMUNN2025_RS01650	COG1335	isochorismatase
SMUNN2025_RS01655	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SMUNN2025_RS01660	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMUNN2025_RS01665	COG0154	amidase activity
SMUNN2025_RS01670	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMUNN2025_RS01680	COG0745	RESPONSE REGULATOR receiver
SMUNN2025_RS01685	COG5002	protein histidine kinase activity
SMUNN2025_RS01745	COG0697	spore germination
SMUNN2025_RS01750	COG1819	glycosyl
SMUNN2025_RS01770	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SMUNN2025_RS01775	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SMUNN2025_RS01780	COG1534	Rna-binding protein
SMUNN2025_RS01785	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SMUNN2025_RS01790	COG1713	HD superfamily hydrolase involved in NAD metabolism
SMUNN2025_RS01795	COG0799	negative regulation of ribosome biogenesis
SMUNN2025_RS01805	COG2226	methyltransferase
SMUNN2025_RS01820	COG1323	Belongs to the UPF0348 family
SMUNN2025_RS01825	COG0789	Transcriptional regulator
SMUNN2025_RS01830	COG0217	transcriptional regulatory protein
SMUNN2025_RS01840	COG1862	Preprotein translocase
SMUNN2025_RS01845	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMUNN2025_RS01850	COG4589	Belongs to the CDS family
SMUNN2025_RS01860	COG0442	prolyl-tRNA aminoacylation
SMUNN2025_RS01915	COG3557	Belongs to the UPF0374 family
SMUNN2025_RS01920	COG2137	regulation of response to DNA damage stimulus
SMUNN2025_RS01925	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMUNN2025_RS01930	COG1780	Probably involved in ribonucleotide reductase function
SMUNN2025_RS01980	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SMUNN2025_RS01985	COG0525	valine-tRNA ligase activity
SMUNN2025_RS01990	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SMUNN2025_RS02085	COG0527	aspartate kinase activity
SMUNN2025_RS02090	COG0546	phosphoglycolate phosphatase activity
SMUNN2025_RS02095	COG1024	Enoyl-CoA hydratase
SMUNN2025_RS02100	COG1846	Transcriptional regulator
SMUNN2025_RS02105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMUNN2025_RS02120	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SMUNN2025_RS02125	COG1028	Short-chain dehydrogenase reductase Sdr
SMUNN2025_RS02130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMUNN2025_RS02140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMUNN2025_RS02145	COG0439	Biotin carboxylase
SMUNN2025_RS02160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SMUNN2025_RS02170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SMUNN2025_RS02180	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SMUNN2025_RS02185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMUNN2025_RS02190	COG0706	membrane insertase activity
SMUNN2025_RS02195	COG1254	Belongs to the acylphosphatase family
SMUNN2025_RS02200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMUNN2025_RS02215	COG0019	diaminopimelate decarboxylase activity
SMUNN2025_RS02220	COG3763	UPF0154 protein
SMUNN2025_RS02225	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SMUNN2025_RS02230	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SMUNN2025_RS02245	COG0582	viral genome integration into host DNA
SMUNN2025_RS02250	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SMUNN2025_RS02255	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SMUNN2025_RS02260	COG1187	pseudouridine synthase activity
SMUNN2025_RS02265	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SMUNN2025_RS02270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SMUNN2025_RS02275	COG0569	domain protein
SMUNN2025_RS02300	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SMUNN2025_RS02305	COG0671	phosphoesterase, PA-phosphatase related
SMUNN2025_RS02315	COG1346	cytolysis
SMUNN2025_RS02320	COG1242	4 iron, 4 sulfur cluster binding
SMUNN2025_RS02325	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SMUNN2025_RS02330	COG1119	ATPase activity
SMUNN2025_RS02335	COG0628	permease
SMUNN2025_RS02340	COG1253	flavin adenine dinucleotide binding
SMUNN2025_RS02345	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SMUNN2025_RS02350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMUNN2025_RS02355	COG1696	Membrane protein involved in D-alanine export
SMUNN2025_RS02360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMUNN2025_RS02365	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SMUNN2025_RS02370	COG1227	inorganic diphosphatase activity
SMUNN2025_RS02380	COG2378	regulation of single-species biofilm formation
SMUNN2025_RS02385	COG0693	protein deglycase activity
SMUNN2025_RS02410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SMUNN2025_RS02415	COG2244	polysaccharide biosynthetic process
SMUNN2025_RS02420	COG0626	cystathionine gamma-synthase activity
SMUNN2025_RS02425	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SMUNN2025_RS02430	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SMUNN2025_RS02435	COG0740	serine-type endopeptidase activity
SMUNN2025_RS02445	COG4471	UPF0298 protein
SMUNN2025_RS02455	COG0559	Belongs to the binding-protein-dependent transport system permease family
SMUNN2025_RS02475	COG0517	IMP dehydrogenase activity
SMUNN2025_RS02480	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SMUNN2025_RS02485	COG0470	DNA polymerase III
SMUNN2025_RS02490	COG1774	PSP1 C-terminal conserved region
SMUNN2025_RS02495	COG4467	Involved in initiation control of chromosome replication
SMUNN2025_RS02505	COG0004	ammonium transporteR
SMUNN2025_RS02510	COG0347	Belongs to the P(II) protein family
SMUNN2025_RS02515	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SMUNN2025_RS02525	COG0454	-acetyltransferase
SMUNN2025_RS02530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMUNN2025_RS02535	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMUNN2025_RS02540	COG1393	Belongs to the ArsC family
SMUNN2025_RS02545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SMUNN2025_RS02550	COG0708	Exodeoxyribonuclease III
SMUNN2025_RS02560	COG0640	Transcriptional regulator
SMUNN2025_RS02595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMUNN2025_RS02595	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMUNN2025_RS02610	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SMUNN2025_RS02635	COG1674	ftsk spoiiie
SMUNN2025_RS02645	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SMUNN2025_RS02650	COG0081	regulation of translation
SMUNN2025_RS02655	COG0528	UMP kinase activity
SMUNN2025_RS02660	COG0233	cytoplasmic translational termination
SMUNN2025_RS02670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMUNN2025_RS02675	COG4479	Belongs to the UPF0346 family
SMUNN2025_RS02680	COG1702	phosphate starvation-inducible protein PhoH
SMUNN2025_RS02685	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SMUNN2025_RS02690	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SMUNN2025_RS02695	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SMUNN2025_RS02710	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SMUNN2025_RS02715	COG0237	dephospho-CoA kinase activity
SMUNN2025_RS02720	COG2264	protein methyltransferase activity
SMUNN2025_RS02725	COG2814	Major facilitator Superfamily
SMUNN2025_RS02730	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMUNN2025_RS02740	COG0557	exoribonuclease II activity
SMUNN2025_RS02745	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SMUNN2025_RS02750	COG2814	Major facilitator Superfamily
SMUNN2025_RS02760	COG0346	lactoylglutathione lyase activity
SMUNN2025_RS02765	COG0778	Nitroreductase
SMUNN2025_RS02775	COG2723	6-phospho-beta-galactosidase activity
SMUNN2025_RS02780	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMUNN2025_RS02785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUNN2025_RS02785	COG3711	transcriptional antiterminator
SMUNN2025_RS02790	COG1447	Phosphotransferase system cellobiose-specific component IIA
SMUNN2025_RS02800	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMUNN2025_RS02820	COG1609	Transcriptional regulator
SMUNN2025_RS02835	COG0438	transferase activity, transferring glycosyl groups
SMUNN2025_RS02845	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMUNN2025_RS02850	COG1956	GAF domain-containing protein
SMUNN2025_RS02855	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SMUNN2025_RS02880	COG0653	protein targeting
SMUNN2025_RS02890	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SMUNN2025_RS02895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMUNN2025_RS02900	COG3842	ATPase activity
SMUNN2025_RS02905	COG3833	ABC-type maltose transport systems, permease component
SMUNN2025_RS02910	COG1175	transmembrane transport
SMUNN2025_RS02920	COG1609	Transcriptional regulator
SMUNN2025_RS02925	COG1640	4-alpha-glucanotransferase
SMUNN2025_RS02930	COG0058	SHG alpha-glucan phosphorylase activity
SMUNN2025_RS02935	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SMUNN2025_RS02940	COG0569	domain protein
SMUNN2025_RS02960	COG4109	DRTGG domain
SMUNN2025_RS02965	COG0024	Methionine aminopeptidase
SMUNN2025_RS02970	COG1295	ribonuclease BN
SMUNN2025_RS02990	COG1131	(ABC) transporter
SMUNN2025_RS03000	COG4585	Histidine kinase
SMUNN2025_RS03005	COG2197	response regulator
SMUNN2025_RS03015	COG4708	membrane
SMUNN2025_RS03020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMUNN2025_RS03025	COG1597	lipid kinase activity
SMUNN2025_RS03030	COG1523	belongs to the glycosyl hydrolase 13 family
SMUNN2025_RS03040	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SMUNN2025_RS03045	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SMUNN2025_RS03050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SMUNN2025_RS03055	COG0297	glycogen (starch) synthase activity
SMUNN2025_RS03060	COG0058	SHG alpha-glucan phosphorylase activity
SMUNN2025_RS03070	COG0356	it plays a direct role in the translocation of protons across the membrane
SMUNN2025_RS03075	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SMUNN2025_RS03080	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMUNN2025_RS03085	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SMUNN2025_RS03090	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SMUNN2025_RS03095	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SMUNN2025_RS03100	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SMUNN2025_RS03110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMUNN2025_RS03125	COG0765	amino acid transport
SMUNN2025_RS03130	COG0765	amino acid transport
SMUNN2025_RS03135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUNN2025_RS03140	COG1126	abc transporter atp-binding protein
SMUNN2025_RS03145	COG0745	RESPONSE REGULATOR receiver
SMUNN2025_RS03150	COG5002	protein histidine kinase activity
SMUNN2025_RS03155	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SMUNN2025_RS03160	COG0571	ribonuclease III activity
SMUNN2025_RS03165	COG1196	nuclear chromosome segregation
SMUNN2025_RS03170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SMUNN2025_RS03180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMUNN2025_RS03180	COG0072	phenylalanine-tRNA ligase activity
SMUNN2025_RS03185	COG1396	sequence-specific DNA binding
SMUNN2025_RS03190	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SMUNN2025_RS03235	COG1857	crispr-associated protein
SMUNN2025_RS03250	COG1518	maintenance of DNA repeat elements
SMUNN2025_RS03260	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SMUNN2025_RS03265	COG1074	ATP-dependent DNA helicase activity
SMUNN2025_RS03270	COG1349	DNA-binding transcription factor activity
SMUNN2025_RS03275	COG0698	ribose 5-phosphate isomerase
SMUNN2025_RS03280	COG0698	ribose 5-phosphate isomerase
SMUNN2025_RS03285	COG1105	Belongs to the carbohydrate kinase PfkB family
SMUNN2025_RS03290	COG3684	Belongs to the aldolase LacD family
SMUNN2025_RS03295	COG1447	Phosphotransferase system cellobiose-specific component IIA
SMUNN2025_RS03300	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMUNN2025_RS03300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMUNN2025_RS03305	COG2723	6-phospho-beta-galactosidase activity
SMUNN2025_RS03330	COG1401	restriction endodeoxyribonuclease activity
SMUNN2025_RS03360	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SMUNN2025_RS03365	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SMUNN2025_RS03375	COG1234	tRNA 3'-trailer cleavage
SMUNN2025_RS03380	COG0300	oxidoreductase activity
SMUNN2025_RS03385	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SMUNN2025_RS03385	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SMUNN2025_RS03390	COG2378	regulation of single-species biofilm formation
SMUNN2025_RS03410	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMUNN2025_RS03415	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SMUNN2025_RS03425	COG2384	SAM-dependent methyltransferase
SMUNN2025_RS03435	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SMUNN2025_RS03445	COG1088	dTDP-glucose 4,6-dehydratase activity
SMUNN2025_RS03455	COG1051	belongs to the nudix hydrolase family
SMUNN2025_RS03460	COG0628	permease
SMUNN2025_RS03470	COG0028	Belongs to the TPP enzyme family
SMUNN2025_RS03475	COG3527	Alpha-acetolactate decarboxylase
SMUNN2025_RS03480	COG1113	amino acid transport
SMUNN2025_RS03485	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SMUNN2025_RS03500	COG3842	ATPase activity
SMUNN2025_RS03515	COG4808	Protein conserved in bacteria
SMUNN2025_RS03525	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SMUNN2025_RS03540	COG1215	transferase activity, transferring glycosyl groups
SMUNN2025_RS03550	COG0488	(ABC) transporter
SMUNN2025_RS03555	COG3442	glutamine amidotransferase
SMUNN2025_RS03560	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SMUNN2025_RS03565	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SMUNN2025_RS03575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMUNN2025_RS03580	COG0542	response to heat
SMUNN2025_RS03590	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SMUNN2025_RS03595	COG0022	dehydrogenase e1 component
SMUNN2025_RS03600	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMUNN2025_RS03605	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMUNN2025_RS03615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMUNN2025_RS03625	COG1051	belongs to the nudix hydrolase family
SMUNN2025_RS03630	COG0647	UMP catabolic process
SMUNN2025_RS03640	COG0577	efflux transmembrane transporter activity
SMUNN2025_RS03640	COG1136	(ABC) transporter
SMUNN2025_RS03650	COG1053	succinate dehydrogenase
SMUNN2025_RS03650	COG3976	FMN-binding domain protein
SMUNN2025_RS03665	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
SMUNN2025_RS03670	COG1518	maintenance of DNA repeat elements
SMUNN2025_RS03675	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SMUNN2025_RS03695	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SMUNN2025_RS03720	COG0481	GTPase activity
SMUNN2025_RS03745	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SMUNN2025_RS03755	COG0673	inositol 2-dehydrogenase activity
SMUNN2025_RS03760	COG0572	uridine kinase
SMUNN2025_RS03770	COG0473	3-isopropylmalate dehydrogenase activity
SMUNN2025_RS03775	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SMUNN2025_RS03780	COG0066	3-isopropylmalate dehydratase activity
SMUNN2025_RS03795	COG0456	acetyltransferase
SMUNN2025_RS03795	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SMUNN2025_RS03805	COG2813	Specifically methylates the guanine in position
SMUNN2025_RS03815	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SMUNN2025_RS03825	COG2884	Cell division ATP-binding protein ftsE
SMUNN2025_RS03830	COG2177	Part of the ABC transporter FtsEX involved in
SMUNN2025_RS03880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SMUNN2025_RS03880	COG1199	ATP-dependent helicase activity
SMUNN2025_RS03885	COG0436	Aminotransferase
SMUNN2025_RS03890	COG0017	Asparaginyl-tRNA synthetase
SMUNN2025_RS03895	COG0371	Dehydrogenase
SMUNN2025_RS03900	COG0251	oxidation-reduction process
SMUNN2025_RS03910	COG1660	Displays ATPase and GTPase activities
SMUNN2025_RS03920	COG1481	regulation of sporulation
SMUNN2025_RS03935	COG2226	methyltransferase
SMUNN2025_RS03950	COG0254	rRNA binding
SMUNN2025_RS03955	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SMUNN2025_RS03960	COG0625	glutathione transferase activity
SMUNN2025_RS03965	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMUNN2025_RS03970	COG0716	FMN binding
SMUNN2025_RS03985	COG1605	Chorismate mutase
SMUNN2025_RS03985	COG0077	Prephenate dehydratase
SMUNN2025_RS03990	COG0038	chloride channel
SMUNN2025_RS03995	COG0038	chloride channel
SMUNN2025_RS04000	COG0335	large ribosomal subunit rRNA binding
SMUNN2025_RS04010	COG2814	Major facilitator Superfamily
SMUNN2025_RS04035	COG0772	Belongs to the SEDS family
SMUNN2025_RS04050	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SMUNN2025_RS04060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMUNN2025_RS04065	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SMUNN2025_RS04070	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SMUNN2025_RS04075	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SMUNN2025_RS04080	COG0560	Phosphoserine phosphatase
SMUNN2025_RS04085	COG0131	Imidazoleglycerol-phosphate dehydratase
SMUNN2025_RS04095	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SMUNN2025_RS04100	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SMUNN2025_RS04105	COG0107	imidazoleglycerol-phosphate synthase activity
SMUNN2025_RS04110	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SMUNN2025_RS04145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SMUNN2025_RS04145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SMUNN2025_RS04150	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SMUNN2025_RS04200	COG0148	phosphopyruvate hydratase activity
SMUNN2025_RS04210	COG1011	Hydrolase
SMUNN2025_RS04225	COG0322	excinuclease ABC activity
SMUNN2025_RS04235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMUNN2025_RS04240	COG1573	uracil-dna glycosylase
SMUNN2025_RS04260	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SMUNN2025_RS04265	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SMUNN2025_RS04270	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SMUNN2025_RS04290	COG0813	purine-nucleoside phosphorylase activity
SMUNN2025_RS04305	COG0543	2 iron, 2 sulfur cluster binding
SMUNN2025_RS04310	COG0167	dihydroorotate dehydrogenase activity
SMUNN2025_RS04315	COG0284	orotidine-5'-phosphate decarboxylase activity
SMUNN2025_RS04320	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SMUNN2025_RS04330	COG1881	PFAM PEBP family protein
SMUNN2025_RS04335	COG2315	Protein conserved in bacteria
SMUNN2025_RS04350	COG0765	amino acid transport
SMUNN2025_RS04355	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SMUNN2025_RS04365	COG0737	Belongs to the 5'-nucleotidase family
SMUNN2025_RS04370	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SMUNN2025_RS04375	COG0187	DNA topoisomerase II activity
SMUNN2025_RS04390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SMUNN2025_RS04410	COG0539	negative regulation of cytoplasmic translation
SMUNN2025_RS04435	COG1131	(ABC) transporter
SMUNN2025_RS04440	COG1725	Transcriptional regulator
SMUNN2025_RS04450	COG0205	6-phosphofructokinase activity
SMUNN2025_RS04455	COG0469	pyruvate kinase activity
SMUNN2025_RS04460	COG2261	transglycosylase associated protein
SMUNN2025_RS04470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMUNN2025_RS04475	COG2213	PTS system mannitol-specific
SMUNN2025_RS04480	COG3711	transcriptional antiterminator
SMUNN2025_RS04485	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUNN2025_RS04490	COG0246	Mannitol dehydrogenase
SMUNN2025_RS04495	COG2824	Alkylphosphonate utilization operon protein PhnA
SMUNN2025_RS04500	COG0765	amino acid transport
SMUNN2025_RS04505	COG1126	abc transporter atp-binding protein
SMUNN2025_RS04510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUNN2025_RS04515	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SMUNN2025_RS04520	COG1115	amino acid carrier protein
SMUNN2025_RS04525	COG0210	DNA helicase
SMUNN2025_RS04530	COG2873	o-acetylhomoserine
SMUNN2025_RS04545	COG0785	Cytochrome C biogenesis protein
SMUNN2025_RS04550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMUNN2025_RS04585	COG2375	cellular response to nickel ion
SMUNN2025_RS04585	COG1132	(ABC) transporter
SMUNN2025_RS04590	COG1132	(ABC) transporter
SMUNN2025_RS04650	COG0745	RESPONSE REGULATOR receiver
SMUNN2025_RS04655	COG2205	protein histidine kinase activity
SMUNN2025_RS04660	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SMUNN2025_RS04665	COG0196	riboflavin kinase activity
SMUNN2025_RS04670	COG1393	Belongs to the ArsC family
SMUNN2025_RS04675	COG4476	Belongs to the UPF0223 family
SMUNN2025_RS04680	COG0483	inositol monophosphate 1-phosphatase activity
SMUNN2025_RS04685	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SMUNN2025_RS04685	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SMUNN2025_RS04695	COG0573	inorganic phosphate transmembrane transporter activity
SMUNN2025_RS04700	COG0581	inorganic phosphate transmembrane transporter activity
SMUNN2025_RS04705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SMUNN2025_RS04710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SMUNN2025_RS04715	COG0704	Plays a role in the regulation of phosphate uptake
SMUNN2025_RS04730	COG0745	RESPONSE REGULATOR receiver
SMUNN2025_RS04735	COG5002	protein histidine kinase activity
SMUNN2025_RS04740	COG0268	Binds directly to 16S ribosomal RNA
SMUNN2025_RS04745	COG1072	(Pantothenic acid kinase))
SMUNN2025_RS04750	COG2813	Specifically methylates the guanine in position
SMUNN2025_RS04755	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SMUNN2025_RS04760	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SMUNN2025_RS04765	COG0295	cytidine deaminase activity
SMUNN2025_RS04770	COG1744	ABC transporter substrate-binding protein PnrA-like
SMUNN2025_RS04775	COG3845	ABC transporter
SMUNN2025_RS04780	COG4603	Belongs to the binding-protein-dependent transport system permease family
SMUNN2025_RS04785	COG1079	Belongs to the binding-protein-dependent transport system permease family
SMUNN2025_RS04800	COG0039	L-malate dehydrogenase activity
SMUNN2025_RS04810	COG3764	Sortase (surface protein transpeptidase)
SMUNN2025_RS04815	COG0346	lactoylglutathione lyase activity
SMUNN2025_RS04830	COG0561	phosphatase activity
SMUNN2025_RS04845	COG0406	alpha-ribazole phosphatase activity
SMUNN2025_RS04855	COG2723	6-phospho-beta-galactosidase activity
SMUNN2025_RS04860	COG0628	permease
SMUNN2025_RS04865	COG1063	alcohol dehydrogenase
SMUNN2025_RS04880	COG1174	glycine betaine transport
SMUNN2025_RS04885	COG1136	(ABC) transporter
SMUNN2025_RS04890	COG0577	efflux transmembrane transporter activity
SMUNN2025_RS04905	COG3976	FMN-binding domain protein
SMUNN2025_RS04905	COG0431	NADPH-dependent FMN reductase
SMUNN2025_RS04905	COG1053	succinate dehydrogenase
SMUNN2025_RS04920	COG1942	4-Oxalocrotonate Tautomerase
SMUNN2025_RS04925	COG1435	thymidine kinase activity
SMUNN2025_RS04930	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SMUNN2025_RS04935	COG2890	protein-(glutamine-N5) methyltransferase activity
SMUNN2025_RS04940	COG0009	L-threonylcarbamoyladenylate synthase
SMUNN2025_RS04945	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMUNN2025_RS04960	COG1132	(ABC) transporter
SMUNN2025_RS04965	COG1132	(ABC) transporter
SMUNN2025_RS04970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMUNN2025_RS04975	COG4684	Psort location CytoplasmicMembrane, score
SMUNN2025_RS04980	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SMUNN2025_RS04990	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SMUNN2025_RS04995	COG1247	-acetyltransferase
SMUNN2025_RS05015	COG1131	(ABC) transporter
SMUNN2025_RS05025	COG0519	Catalyzes the synthesis of GMP from XMP
SMUNN2025_RS05030	COG2188	Transcriptional regulator
SMUNN2025_RS05040	COG4175	Glycine betaine
SMUNN2025_RS05040	COG3448	diguanylate cyclase activity
SMUNN2025_RS05050	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SMUNN2025_RS05055	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SMUNN2025_RS05080	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SMUNN2025_RS05085	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SMUNN2025_RS05095	COG1104	cysteine desulfurase activity
SMUNN2025_RS05100	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMUNN2025_RS05105	COG4116	CYTH
SMUNN2025_RS05115	COG2357	RelA SpoT domain protein
SMUNN2025_RS05120	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SMUNN2025_RS05125	COG0564	pseudouridine synthase activity
SMUNN2025_RS05130	COG0280	phosphate acetyltransferase
SMUNN2025_RS05140	COG1131	(ABC) transporter
SMUNN2025_RS05145	COG4221	oxidoreductase activity
SMUNN2025_RS05150	COG1442	glycosyl transferase family 8
SMUNN2025_RS05155	COG0745	RESPONSE REGULATOR receiver
SMUNN2025_RS05160	COG5002	protein histidine kinase activity
SMUNN2025_RS05170	COG1131	(ABC) transporter
SMUNN2025_RS05175	COG4974	Belongs to the 'phage' integrase family
SMUNN2025_RS05200	COG3052	prosthetic group binding
SMUNN2025_RS05210	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SMUNN2025_RS05215	COG0511	ligase activity, forming carbon-carbon bonds
SMUNN2025_RS05225	COG2851	Citrate transporter
SMUNN2025_RS05235	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
SMUNN2025_RS05240	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SMUNN2025_RS05245	COG0642	Histidine kinase
SMUNN2025_RS05250	COG0745	RESPONSE REGULATOR receiver
SMUNN2025_RS05260	COG1136	(ABC) transporter
SMUNN2025_RS05265	COG0366	Alpha amylase catalytic
SMUNN2025_RS05265	COG5263	repeat protein
SMUNN2025_RS05270	COG5263	repeat protein
SMUNN2025_RS05270	COG0366	Alpha amylase catalytic
SMUNN2025_RS05275	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SMUNN2025_RS05280	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMUNN2025_RS05300	COG4607	ABC-type enterochelin transport system periplasmic component
SMUNN2025_RS05305	COG4604	ABC transporter, ATP-binding protein
SMUNN2025_RS05310	COG4605	iron ion homeostasis
SMUNN2025_RS05315	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMUNN2025_RS05320	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SMUNN2025_RS05325	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SMUNN2025_RS05340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMUNN2025_RS05345	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SMUNN2025_RS05355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SMUNN2025_RS05360	COG4932	domain protein
SMUNN2025_RS05390	COG1263	PTS System
SMUNN2025_RS05390	COG2190	(PTS) system
SMUNN2025_RS05390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMUNN2025_RS05395	COG3711	transcriptional antiterminator
SMUNN2025_RS05405	COG1177	transmembrane transport
SMUNN2025_RS05410	COG1176	ABC-type spermidine putrescine transport system, permease component I
SMUNN2025_RS05415	COG3842	ATPase activity
SMUNN2025_RS05420	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SMUNN2025_RS05440	COG0302	gtp cyclohydrolase
SMUNN2025_RS05445	COG0285	dihydrofolate synthase activity
SMUNN2025_RS05450	COG0083	homoserine kinase activity
SMUNN2025_RS05460	COG0726	polysaccharide deacetylase
SMUNN2025_RS05465	COG1960	acyl-CoA dehydrogenase activity
SMUNN2025_RS05525	COG0222	ribosome binding
SMUNN2025_RS05530	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SMUNN2025_RS05550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMUNN2025_RS05555	COG2040	homocysteine
SMUNN2025_RS05560	COG0833	amino acid
SMUNN2025_RS05565	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SMUNN2025_RS05570	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SMUNN2025_RS05580	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SMUNN2025_RS05585	COG3201	nicotinamide mononucleotide transporter
SMUNN2025_RS05590	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SMUNN2025_RS05595	COG3425	synthase
SMUNN2025_RS05610	COG1272	protein, Hemolysin III
SMUNN2025_RS05620	COG1304	FMN binding
SMUNN2025_RS05635	COG1126	abc transporter atp-binding protein
SMUNN2025_RS05640	COG0765	amino acid transport
SMUNN2025_RS05645	COG0765	amino acid transport
SMUNN2025_RS05650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUNN2025_RS05660	COG0583	DNA-binding transcription factor activity
SMUNN2025_RS05665	COG3759	membrane
SMUNN2025_RS05675	COG0745	RESPONSE REGULATOR receiver
SMUNN2025_RS05680	COG2357	RelA SpoT domain protein
SMUNN2025_RS05690	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SMUNN2025_RS05695	COG1132	(ABC) transporter
SMUNN2025_RS05710	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SMUNN2025_RS05725	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SMUNN2025_RS05735	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SMUNN2025_RS05745	COG5263	repeat protein
SMUNN2025_RS05745	COG0366	Alpha amylase catalytic
SMUNN2025_RS05755	COG1132	(ABC) transporter
SMUNN2025_RS05770	COG0488	(ABC) transporter
SMUNN2025_RS05775	COG0617	tRNA 3'-terminal CCA addition
SMUNN2025_RS05780	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SMUNN2025_RS05785	COG1307	EDD domain protein, DegV family
SMUNN2025_RS05800	COG1131	(ABC) transporter
SMUNN2025_RS05815	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SMUNN2025_RS05820	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SMUNN2025_RS05825	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SMUNN2025_RS05830	COG1609	Transcriptional regulator
SMUNN2025_RS05835	COG0366	Alpha amylase catalytic
SMUNN2025_RS05840	COG3842	ATPase activity
SMUNN2025_RS05845	COG0366	Alpha amylase catalytic
SMUNN2025_RS05850	COG0395	ABC-type sugar transport system, permease component
SMUNN2025_RS05855	COG1175	transmembrane transport
SMUNN2025_RS05860	COG1653	transport
SMUNN2025_RS05865	COG3345	alpha-galactosidase
SMUNN2025_RS05870	COG2207	Transcriptional regulator
SMUNN2025_RS05895	COG0646	methionine synthase
SMUNN2025_RS05895	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SMUNN2025_RS05900	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SMUNN2025_RS05905	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMUNN2025_RS05905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUNN2025_RS05905	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMUNN2025_RS05910	COG1105	Belongs to the carbohydrate kinase PfkB family
SMUNN2025_RS05915	COG1349	DNA-binding transcription factor activity
SMUNN2025_RS05920	COG0492	ferredoxin-NADP+ reductase activity
SMUNN2025_RS05925	COG0336	Belongs to the RNA methyltransferase TrmD family
SMUNN2025_RS05930	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SMUNN2025_RS05935	COG1837	Belongs to the UPF0109 family
SMUNN2025_RS05940	COG0228	four-way junction DNA binding
SMUNN2025_RS05945	COG0577	efflux transmembrane transporter activity
SMUNN2025_RS05950	COG1136	(ABC) transporter
SMUNN2025_RS05960	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SMUNN2025_RS05965	COG0505	Belongs to the CarA family
SMUNN2025_RS05970	COG0540	Belongs to the ATCase OTCase family
SMUNN2025_RS05980	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SMUNN2025_RS05990	COG0564	pseudouridine synthase activity
SMUNN2025_RS05995	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SMUNN2025_RS06000	COG0583	DNA-binding transcription factor activity
SMUNN2025_RS06005	COG2816	NAD+ diphosphatase activity
SMUNN2025_RS06015	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SMUNN2025_RS06025	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SMUNN2025_RS06045	COG0301	tRNA thio-modification
SMUNN2025_RS06050	COG1104	cysteine desulfurase activity
SMUNN2025_RS06060	COG0285	dihydrofolate synthase activity
SMUNN2025_RS06065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMUNN2025_RS06070	COG0656	L-ascorbic acid biosynthetic process
SMUNN2025_RS06075	COG3942	CHAP domain
SMUNN2025_RS06090	COG0463	Glycosyl transferase, family 2
SMUNN2025_RS06100	COG1368	sulfuric ester hydrolase activity
SMUNN2025_RS06135	COG1091	dTDP-4-dehydrorhamnose reductase activity
SMUNN2025_RS06140	COG2151	metal-sulfur cluster biosynthetic enzyme
SMUNN2025_RS06145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMUNN2025_RS06150	COG0358	DNA primase activity
SMUNN2025_RS06160	COG1970	mechanosensitive ion channel activity
SMUNN2025_RS06170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUNN2025_RS06180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUNN2025_RS06185	COG1051	belongs to the nudix hydrolase family
SMUNN2025_RS06200	COG0556	nucleotide-excision repair
SMUNN2025_RS06215	COG1126	abc transporter atp-binding protein
SMUNN2025_RS06220	COG0488	(ABC) transporter
SMUNN2025_RS06230	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SMUNN2025_RS06270	COG3620	sequence-specific DNA binding
SMUNN2025_RS06280	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMUNN2025_RS06290	COG0077	Prephenate dehydratase
SMUNN2025_RS06295	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SMUNN2025_RS06300	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SMUNN2025_RS06305	COG3679	Belongs to the UPF0342 family
SMUNN2025_RS06310	COG0287	Prephenate dehydrogenase
SMUNN2025_RS06315	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SMUNN2025_RS06320	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SMUNN2025_RS06325	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SMUNN2025_RS06330	COG0710	3-dehydroquinate dehydratase activity
SMUNN2025_RS06335	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SMUNN2025_RS06340	COG1368	sulfuric ester hydrolase activity
SMUNN2025_RS06360	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SMUNN2025_RS06365	COG0366	Alpha amylase catalytic
SMUNN2025_RS06365	COG5263	repeat protein
SMUNN2025_RS06375	COG1914	H( )-stimulated, divalent metal cation uptake system
SMUNN2025_RS06380	COG4443	Transcriptional Coactivator p15 (PC4)
SMUNN2025_RS06395	COG0450	alkyl hydroperoxide reductase
SMUNN2025_RS06400	COG0826	peptidase U32
SMUNN2025_RS06425	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SMUNN2025_RS06430	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SMUNN2025_RS06440	COG3091	SprT-like family
SMUNN2025_RS06445	COG2183	response to ionizing radiation
SMUNN2025_RS06460	COG0701	Predicted permease
SMUNN2025_RS06465	COG3689	TIGRFAM TIGR03943 family protein
SMUNN2025_RS06470	COG0477	Major facilitator Superfamily
SMUNN2025_RS06475	COG0552	protein localization to endoplasmic reticulum
SMUNN2025_RS06480	COG0561	phosphatase activity
SMUNN2025_RS06485	COG0561	phosphatase activity
SMUNN2025_RS06530	COG1131	(ABC) transporter
SMUNN2025_RS06540	COG0604	alcohol dehydrogenase
SMUNN2025_RS06555	COG0584	glycerophosphoryl diester phosphodiesterase
SMUNN2025_RS06575	COG1078	dGTPase activity
SMUNN2025_RS06585	COG2348	transferase activity, transferring amino-acyl groups
SMUNN2025_RS06595	COG0149	triose-phosphate isomerase activity
SMUNN2025_RS06600	COG2274	protein secretion by the type I secretion system
SMUNN2025_RS06625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMUNN2025_RS06630	COG0772	Belongs to the SEDS family
SMUNN2025_RS06635	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SMUNN2025_RS06655	COG3859	Proton-coupled thiamine transporter YuaJ
SMUNN2025_RS06670	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SMUNN2025_RS06680	COG0588	phosphoglycerate mutase activity
SMUNN2025_RS06685	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SMUNN2025_RS06690	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SMUNN2025_RS06695	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SMUNN2025_RS06700	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SMUNN2025_RS06720	COG2195	Cleaves the N-terminal amino acid of tripeptides
SMUNN2025_RS06745	COG0656	L-ascorbic acid biosynthetic process
SMUNN2025_RS06750	COG0656	L-ascorbic acid biosynthetic process
SMUNN2025_RS06755	COG0789	Transcriptional regulator
SMUNN2025_RS06760	COG1012	belongs to the aldehyde dehydrogenase family
SMUNN2025_RS06765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMUNN2025_RS06770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUNN2025_RS06780	COG0538	isocitrate dehydrogenase activity
SMUNN2025_RS06785	COG0372	Belongs to the citrate synthase family
SMUNN2025_RS06790	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SMUNN2025_RS06795	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SMUNN2025_RS06800	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMUNN2025_RS06810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMUNN2025_RS06815	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SMUNN2025_RS06820	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SMUNN2025_RS06825	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SMUNN2025_RS06875	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMUNN2025_RS06885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMUNN2025_RS06890	COG4122	O-methyltransferase activity
SMUNN2025_RS06895	COG0131	Imidazoleglycerol-phosphate dehydratase
SMUNN2025_RS06895	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SMUNN2025_RS06915	COG0604	alcohol dehydrogenase
SMUNN2025_RS06915	COG3321	synthase
SMUNN2025_RS06915	COG1028	Short-chain dehydrogenase reductase Sdr
SMUNN2025_RS06920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMUNN2025_RS06930	COG1187	pseudouridine synthase activity
SMUNN2025_RS06940	COG0363	glucosamine-6-phosphate deaminase activity
SMUNN2025_RS06950	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SMUNN2025_RS06975	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SMUNN2025_RS06985	COG2801	Transposase and inactivated derivatives
SMUNN2025_RS07000	COG2333	competence protein COMEC
SMUNN2025_RS07000	COG0658	competence protein
SMUNN2025_RS07005	COG1596	polysaccharide export
SMUNN2025_RS07005	COG1555	photosystem II stabilization
SMUNN2025_RS07010	COG0204	Acyl-transferase
SMUNN2025_RS07015	COG0726	polysaccharide deacetylase
SMUNN2025_RS07025	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SMUNN2025_RS07040	COG0513	Belongs to the DEAD box helicase family
SMUNN2025_RS07045	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SMUNN2025_RS07045	COG3064	Membrane
SMUNN2025_RS07055	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SMUNN2025_RS07065	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SMUNN2025_RS07070	COG0385	Bile acid
SMUNN2025_RS07080	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMUNN2025_RS07085	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SMUNN2025_RS07090	COG0768	penicillin binding
SMUNN2025_RS07095	COG0588	phosphoglycerate mutase activity
SMUNN2025_RS07110	COG0735	belongs to the Fur family
SMUNN2025_RS07125	COG0776	regulation of translation
SMUNN2025_RS07135	COG2755	lipolytic protein G-D-S-L family
SMUNN2025_RS07140	COG1307	EDD domain protein, DegV family
SMUNN2025_RS07145	COG0497	DNA recombination
SMUNN2025_RS07150	COG1438	arginine binding
SMUNN2025_RS07155	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SMUNN2025_RS07165	COG1722	exodeoxyribonuclease VII activity
SMUNN2025_RS07170	COG1570	exodeoxyribonuclease VII activity
SMUNN2025_RS07175	COG3275	phosphorelay sensor kinase activity
SMUNN2025_RS07180	COG3279	Response regulator of the LytR AlgR family
SMUNN2025_RS07185	COG1380	Effector of murein hydrolase LrgA
SMUNN2025_RS07190	COG1346	cytolysis
SMUNN2025_RS07195	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SMUNN2025_RS07200	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SMUNN2025_RS07220	COG1126	abc transporter atp-binding protein
SMUNN2025_RS07225	COG0765	amino acid transport
SMUNN2025_RS07230	COG4703	Protein of unknown function (DUF1797)
SMUNN2025_RS07235	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMUNN2025_RS07240	COG0542	response to heat
SMUNN2025_RS07260	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SMUNN2025_RS07265	COG3599	regulation of cell shape
SMUNN2025_RS07270	COG2302	S4 RNA-binding domain
SMUNN2025_RS07280	COG1799	cell septum assembly
SMUNN2025_RS07285	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SMUNN2025_RS07295	COG0849	cell division
SMUNN2025_RS07305	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SMUNN2025_RS07310	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SMUNN2025_RS07320	COG1217	gtp-binding protein TYPA
SMUNN2025_RS07325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SMUNN2025_RS07330	COG1940	carbohydrate kinase activity
SMUNN2025_RS07340	COG0783	Belongs to the Dps family
SMUNN2025_RS07350	COG0159	tryptophan synthase activity
SMUNN2025_RS07355	COG0133	tryptophan synthase activity
SMUNN2025_RS07360	COG0135	phosphoribosylanthranilate isomerase activity
SMUNN2025_RS07365	COG0134	indole-3-glycerol-phosphate synthase activity
SMUNN2025_RS07370	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SMUNN2025_RS07375	COG0512	Glutamine amidotransferase of anthranilate synthase
SMUNN2025_RS07380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SMUNN2025_RS07400	COG3804	dihydrodipicolinate reductase
SMUNN2025_RS07410	COG1132	(ABC) transporter
SMUNN2025_RS07415	COG1132	(ABC) transporter
SMUNN2025_RS07425	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SMUNN2025_RS07430	COG4470	Protein conserved in bacteria
SMUNN2025_RS07435	COG0737	Belongs to the 5'-nucleotidase family
SMUNN2025_RS07440	COG3480	Lon protease (S16) C-terminal proteolytic domain
SMUNN2025_RS07445	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SMUNN2025_RS07450	COG0742	ribosomal rna small subunit methyltransferase
SMUNN2025_RS07455	COG4716	Myosin-crossreactive antigen
SMUNN2025_RS07495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUNN2025_RS07505	COG0561	phosphatase activity
SMUNN2025_RS07510	COG1349	DNA-binding transcription factor activity
SMUNN2025_RS07555	COG1040	competence protein
SMUNN2025_RS07560	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SMUNN2025_RS07565	COG1739	Uncharacterized protein family UPF0029
SMUNN2025_RS07585	COG1882	Formate acetyltransferase
SMUNN2025_RS07590	COG1349	DNA-binding transcription factor activity
SMUNN2025_RS07595	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SMUNN2025_RS07600	COG1098	S1 RNA binding domain
SMUNN2025_RS07610	COG2197	response regulator
SMUNN2025_RS07615	COG4585	Histidine kinase
SMUNN2025_RS07635	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMUNN2025_RS07635	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SMUNN2025_RS07640	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SMUNN2025_RS07645	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SMUNN2025_RS07650	COG1758	RNA polymerase activity
SMUNN2025_RS07655	COG0194	GDP metabolic process
SMUNN2025_RS07660	COG4372	Transposase
SMUNN2025_RS07660	COG1418	mRNA catabolic process
SMUNN2025_RS07665	COG1854	S-ribosylhomocysteine lyase activity
SMUNN2025_RS07675	COG0116	Belongs to the methyltransferase superfamily
SMUNN2025_RS07680	COG3599	regulation of cell shape
SMUNN2025_RS07685	COG4474	Belongs to the UPF0398 family
SMUNN2025_RS07690	COG3331	DNA recombination
SMUNN2025_RS07695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMUNN2025_RS07700	COG3579	cysteine-type endopeptidase activity
SMUNN2025_RS07705	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMUNN2025_RS07710	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SMUNN2025_RS07715	COG0492	ferredoxin-NADP+ reductase activity
SMUNN2025_RS07725	COG1126	abc transporter atp-binding protein
SMUNN2025_RS07740	COG0513	Belongs to the DEAD box helicase family
SMUNN2025_RS07750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMUNN2025_RS07755	COG0768	penicillin binding
SMUNN2025_RS07760	COG4839	cell division protein FtsL
SMUNN2025_RS07765	COG0275	rRNA processing
SMUNN2025_RS07770	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SMUNN2025_RS07775	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SMUNN2025_RS07785	COG4224	UPF0291 protein
SMUNN2025_RS07790	COG0751	glycine-tRNA ligase activity
SMUNN2025_RS07795	COG0752	glycyl-tRNA synthetase alpha subunit
SMUNN2025_RS07800	COG1673	EVE domain
SMUNN2025_RS07820	COG1924	4 iron, 4 sulfur cluster binding
SMUNN2025_RS07845	COG1131	(ABC) transporter
SMUNN2025_RS07855	COG0561	phosphatase activity
SMUNN2025_RS07865	COG2217	Heavy metal translocating P-type atpase
SMUNN2025_RS07885	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SMUNN2025_RS07890	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SMUNN2025_RS07900	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SMUNN2025_RS07905	COG0195	Participates in both transcription termination and antitermination
SMUNN2025_RS07910	COG0779	Required for maturation of 30S ribosomal subunits
SMUNN2025_RS07920	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SMUNN2025_RS07930	COG4473	ABC transporter
SMUNN2025_RS07935	COG1131	(ABC) transporter
SMUNN2025_RS07940	COG0537	adenosine 5'-monophosphoramidase activity
SMUNN2025_RS07950	COG1316	TRANSCRIPTIONal
SMUNN2025_RS07955	COG0802	atpase or kinase
SMUNN2025_RS07960	COG2252	PERMEase
SMUNN2025_RS07970	COG0561	phosphatase activity
SMUNN2025_RS07985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMUNN2025_RS07990	COG1882	Formate acetyltransferase
SMUNN2025_RS08000	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMUNN2025_RS08015	COG2936	dipeptidyl-peptidase activity
SMUNN2025_RS08020	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SMUNN2025_RS08025	COG1733	regulation of RNA biosynthetic process
SMUNN2025_RS08030	COG0778	Nitroreductase
SMUNN2025_RS08040	COG2081	HI0933 family
SMUNN2025_RS08060	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SMUNN2025_RS08065	COG0456	acetyltransferase
SMUNN2025_RS08070	COG1214	PFAM Peptidase M22, glycoprotease
SMUNN2025_RS08080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMUNN2025_RS08085	COG0667	Aldo Keto reductase
SMUNN2025_RS08105	COG5503	Protein of unknown function (DUF1447)
SMUNN2025_RS08115	COG3942	CHAP domain
SMUNN2025_RS08120	COG0493	'glutamate synthase
SMUNN2025_RS08125	COG0070	glutamate synthase
SMUNN2025_RS08125	COG0067	glutamate synthase
SMUNN2025_RS08125	COG0069	glutamate synthase activity
SMUNN2025_RS08130	COG0174	glutamine synthetase
SMUNN2025_RS08135	COG0789	Transcriptional regulator
SMUNN2025_RS08145	COG0126	phosphoglycerate kinase activity
SMUNN2025_RS08155	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SMUNN2025_RS08160	COG0049	tRNA binding
SMUNN2025_RS08165	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SMUNN2025_RS08170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMUNN2025_RS08195	COG1162	GTPase activity
SMUNN2025_RS08215	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SMUNN2025_RS08250	COG0084	hydrolase, TatD family'
SMUNN2025_RS08260	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SMUNN2025_RS08275	COG0706	membrane insertase activity
SMUNN2025_RS08280	COG0594	ribonuclease P activity
SMUNN2025_RS08285	COG0165	Argininosuccinate lyase
SMUNN2025_RS08290	COG0137	argininosuccinate synthase activity
SMUNN2025_RS08305	COG1827	regulation of RNA biosynthetic process
SMUNN2025_RS08310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMUNN2025_RS08335	COG0756	dUTP diphosphatase activity
SMUNN2025_RS08340	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SMUNN2025_RS08345	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SMUNN2025_RS08350	COG0457	Tetratricopeptide repeat
SMUNN2025_RS08350	COG0705	Rhomboid family
SMUNN2025_RS08355	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SMUNN2025_RS08360	COG1473	amidohydrolase
SMUNN2025_RS08365	COG2171	N-acyltransferase activity
SMUNN2025_RS08400	COG3732	PTS system glucitol sorbitol-specific
SMUNN2025_RS08405	COG3730	PTS system glucitol sorbitol-specific
SMUNN2025_RS08415	COG3711	transcriptional antiterminator
SMUNN2025_RS08415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUNN2025_RS08425	COG0166	Belongs to the GPI family
SMUNN2025_RS08435	COG1028	Short-chain dehydrogenase reductase Sdr
SMUNN2025_RS08440	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SMUNN2025_RS08460	COG1136	(ABC) transporter
SMUNN2025_RS08480	COG1131	(ABC) transporter
SMUNN2025_RS08490	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SMUNN2025_RS08525	COG1234	tRNA 3'-trailer cleavage
SMUNN2025_RS08540	COG0343	queuine tRNA-ribosyltransferase activity
SMUNN2025_RS08550	COG1832	CoA-binding protein
SMUNN2025_RS08555	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMUNN2025_RS08555	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMUNN2025_RS08585	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SMUNN2025_RS08605	COG2274	protein secretion by the type I secretion system
SMUNN2025_RS08640	COG3623	hexulose-6-phosphate isomerase
SMUNN2025_RS08650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUNN2025_RS08665	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SMUNN2025_RS08670	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMUNN2025_RS08670	COG2918	glutathione biosynthetic process
SMUNN2025_RS08680	COG4608	Belongs to the ABC transporter superfamily
SMUNN2025_RS08685	COG0444	Belongs to the ABC transporter superfamily
SMUNN2025_RS08690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMUNN2025_RS08695	COG0601	transmembrane transport
SMUNN2025_RS08700	COG4166	transmembrane transport
SMUNN2025_RS08715	COG0719	Fe-S assembly protein
SMUNN2025_RS08725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMUNN2025_RS08730	COG0719	Fe-S assembly protein
SMUNN2025_RS08740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMUNN2025_RS08745	COG4862	establishment of competence for transformation
SMUNN2025_RS08750	COG1968	undecaprenyl-diphosphatase activity
SMUNN2025_RS08760	COG0765	amino acid transport
SMUNN2025_RS08765	COG1126	abc transporter atp-binding protein
SMUNN2025_RS08775	COG1131	(ABC) transporter
SMUNN2025_RS08785	COG1309	transcriptional regulator
SMUNN2025_RS08795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SMUNN2025_RS08800	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SMUNN2025_RS08805	COG0440	acetolactate synthase activity
SMUNN2025_RS08810	COG0028	Belongs to the TPP enzyme family
SMUNN2025_RS08940	COG0203	ribosomal protein L17
SMUNN2025_RS08945	COG0202	RNA polymerase activity
SMUNN2025_RS08950	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SMUNN2025_RS08955	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SMUNN2025_RS08965	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SMUNN2025_RS08970	COG0563	adenylate kinase activity
SMUNN2025_RS08975	COG0201	protein transport
SMUNN2025_RS08980	COG0200	Binds to the 23S rRNA
SMUNN2025_RS08985	COG1841	ribosomal large subunit assembly
SMUNN2025_RS08990	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SMUNN2025_RS09000	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SMUNN2025_RS09005	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SMUNN2025_RS09010	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SMUNN2025_RS09015	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SMUNN2025_RS09020	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SMUNN2025_RS09025	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SMUNN2025_RS09030	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SMUNN2025_RS09035	COG0255	Belongs to the universal ribosomal protein uL29 family
SMUNN2025_RS09040	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SMUNN2025_RS09045	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SMUNN2025_RS09050	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SMUNN2025_RS09060	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SMUNN2025_RS09065	COG0089	rRNA binding
SMUNN2025_RS09075	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SMUNN2025_RS09080	COG0051	transcription antitermination factor activity, RNA binding
SMUNN2025_RS09090	COG1621	beta-fructofuranosidase activity
SMUNN2025_RS09095	COG0542	response to heat
SMUNN2025_RS09100	COG4463	regulation of RNA biosynthetic process
SMUNN2025_RS09110	COG0477	Major facilitator Superfamily
SMUNN2025_RS09135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMUNN2025_RS09155	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SMUNN2025_RS09160	COG0052	Belongs to the universal ribosomal protein uS2 family
SMUNN2025_RS09175	COG1619	proteins homologs of microcin C7 resistance protein MccF
SMUNN2025_RS09180	COG3590	peptidase
SMUNN2025_RS09185	COG0366	Alpha amylase catalytic
SMUNN2025_RS09190	COG1263	PTS System
SMUNN2025_RS09190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMUNN2025_RS09195	COG2188	Transcriptional regulator
SMUNN2025_RS09200	COG5297	Belongs to the glycosyl hydrolase family 6
SMUNN2025_RS09205	COG1490	D-aminoacyl-tRNA deacylase activity
SMUNN2025_RS09220	COG1263	PTS System
SMUNN2025_RS09220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMUNN2025_RS09220	COG2190	(PTS) system
SMUNN2025_RS09225	COG1609	Transcriptional regulator
SMUNN2025_RS09230	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SMUNN2025_RS09235	COG2264	protein methyltransferase activity
SMUNN2025_RS09255	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SMUNN2025_RS09265	COG2217	Heavy metal translocating P-type atpase
SMUNN2025_RS09275	COG2855	membrane
SMUNN2025_RS09280	COG0583	DNA-binding transcription factor activity
SMUNN2025_RS09290	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SMUNN2025_RS09300	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SMUNN2025_RS09310	COG0463	Glycosyl transferase, family 2
SMUNN2025_RS09315	COG0428	transporter
SMUNN2025_RS09320	COG3022	response to hydroperoxide
SMUNN2025_RS09355	COG3906	Belongs to the UPF0473 family
SMUNN2025_RS09360	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SMUNN2025_RS09365	COG4472	Bacterial protein of unknown function (DUF965)
SMUNN2025_RS09385	COG1393	Belongs to the ArsC family
SMUNN2025_RS09390	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SMUNN2025_RS09395	COG1546	Belongs to the CinA family
SMUNN2025_RS09395	COG1058	Belongs to the CinA family
SMUNN2025_RS09400	COG0519	Catalyzes the synthesis of GMP from XMP
SMUNN2025_RS09405	COG0632	four-way junction helicase activity
SMUNN2025_RS09410	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SMUNN2025_RS09420	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SMUNN2025_RS09430	COG1438	arginine binding
SMUNN2025_RS09450	COG0018	arginyl-trna synthetase
SMUNN2025_RS09455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SMUNN2025_RS09460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SMUNN2025_RS09465	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SMUNN2025_RS09470	COG0124	histidyl-tRNA synthetase
SMUNN2025_RS09475	COG0531	amino acid
SMUNN2025_RS09480	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SMUNN2025_RS09485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMUNN2025_RS09510	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SMUNN2025_RS09520	COG0640	Transcriptional regulator
SMUNN2025_RS09545	COG0789	Transcriptional regulator
SMUNN2025_RS09550	COG1028	Short-chain dehydrogenase reductase Sdr
SMUNN2025_RS09575	COG2094	Belongs to the DNA glycosylase MPG family
SMUNN2025_RS09590	COG1733	regulation of RNA biosynthetic process
SMUNN2025_RS09600	COG1012	belongs to the aldehyde dehydrogenase family
SMUNN2025_RS09605	COG0129	dihydroxy-acid dehydratase activity
SMUNN2025_RS09610	COG2151	metal-sulfur cluster biosynthetic enzyme
SMUNN2025_RS09630	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMUNN2025_RS09640	COG0305	Participates in initiation and elongation during chromosome replication
SMUNN2025_RS09645	COG0359	binds to the 23S rRNA
SMUNN2025_RS09655	COG0445	tRNA wobble uridine modification
SMUNN2025_RS09665	COG0482	sulfurtransferase activity
SMUNN2025_RS09670	COG0741	lytic transglycosylase activity
SMUNN2025_RS09680	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SMUNN2025_RS09685	COG1122	ATPase activity
SMUNN2025_RS09690	COG1122	ATPase activity
SMUNN2025_RS09695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SMUNN2025_RS09705	COG0612	Peptidase, M16
SMUNN2025_RS09720	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SMUNN2025_RS09725	COG0517	IMP dehydrogenase activity
SMUNN2025_RS09725	COG0516	GMP reductase activity
SMUNN2025_RS09730	COG0180	Tryptophanyl-tRNA synthetase
SMUNN2025_RS09735	COG0488	(ABC) transporter
SMUNN2025_RS09765	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SMUNN2025_RS09770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMUNN2025_RS09775	COG1475	DNA binding