locus-tag	class	description
HB751_RS00070	COG0527	aspartate kinase activity
HB751_RS00075	COG0546	phosphoglycolate phosphatase activity
HB751_RS00080	COG1024	Enoyl-CoA hydratase
HB751_RS00085	COG1846	Transcriptional regulator
HB751_RS00090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HB751_RS00105	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HB751_RS00110	COG1028	Short-chain dehydrogenase reductase Sdr
HB751_RS00115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HB751_RS00125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HB751_RS00130	COG0439	Biotin carboxylase
HB751_RS00145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HB751_RS00155	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HB751_RS00165	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HB751_RS00170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HB751_RS00175	COG0706	membrane insertase activity
HB751_RS00180	COG1254	Belongs to the acylphosphatase family
HB751_RS00185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HB751_RS00200	COG0019	diaminopimelate decarboxylase activity
HB751_RS00205	COG3763	UPF0154 protein
HB751_RS00210	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HB751_RS00215	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HB751_RS00230	COG0582	viral genome integration into host DNA
HB751_RS00235	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HB751_RS00240	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HB751_RS00245	COG1187	pseudouridine synthase activity
HB751_RS00250	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HB751_RS00255	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HB751_RS00260	COG0569	domain protein
HB751_RS00285	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HB751_RS00290	COG0671	phosphoesterase, PA-phosphatase related
HB751_RS00300	COG1346	cytolysis
HB751_RS00305	COG1242	4 iron, 4 sulfur cluster binding
HB751_RS00310	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HB751_RS00315	COG1119	ATPase activity
HB751_RS00320	COG0628	permease
HB751_RS00325	COG1253	flavin adenine dinucleotide binding
HB751_RS00330	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HB751_RS00340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB751_RS00345	COG1696	Membrane protein involved in D-alanine export
HB751_RS00350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB751_RS00355	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HB751_RS00360	COG1227	inorganic diphosphatase activity
HB751_RS00370	COG2378	regulation of single-species biofilm formation
HB751_RS00375	COG0693	protein deglycase activity
HB751_RS00400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HB751_RS00405	COG2244	polysaccharide biosynthetic process
HB751_RS00410	COG0626	cystathionine gamma-synthase activity
HB751_RS00415	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HB751_RS00420	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HB751_RS00425	COG0740	serine-type endopeptidase activity
HB751_RS00435	COG4471	UPF0298 protein
HB751_RS00445	COG0559	Belongs to the binding-protein-dependent transport system permease family
HB751_RS00465	COG0517	IMP dehydrogenase activity
HB751_RS00470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HB751_RS00475	COG0470	DNA polymerase III
HB751_RS00480	COG1774	PSP1 C-terminal conserved region
HB751_RS00485	COG4467	Involved in initiation control of chromosome replication
HB751_RS00495	COG0004	ammonium transporteR
HB751_RS00500	COG0347	Belongs to the P(II) protein family
HB751_RS00505	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HB751_RS00515	COG0454	-acetyltransferase
HB751_RS00520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB751_RS00525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HB751_RS00530	COG1393	Belongs to the ArsC family
HB751_RS00535	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HB751_RS00540	COG0708	Exodeoxyribonuclease III
HB751_RS00550	COG0640	Transcriptional regulator
HB751_RS00585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB751_RS00585	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB751_RS00615	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HB751_RS00640	COG1674	ftsk spoiiie
HB751_RS00650	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HB751_RS00655	COG0081	regulation of translation
HB751_RS00660	COG0528	UMP kinase activity
HB751_RS00665	COG0233	cytoplasmic translational termination
HB751_RS00675	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HB751_RS00680	COG4479	Belongs to the UPF0346 family
HB751_RS00685	COG1702	phosphate starvation-inducible protein PhoH
HB751_RS00690	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HB751_RS00695	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HB751_RS00700	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HB751_RS00715	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HB751_RS00720	COG0237	dephospho-CoA kinase activity
HB751_RS00730	COG2814	Major facilitator Superfamily
HB751_RS00735	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HB751_RS00745	COG0557	exoribonuclease II activity
HB751_RS00750	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HB751_RS00755	COG0346	lactoylglutathione lyase activity
HB751_RS00760	COG0778	Nitroreductase
HB751_RS00770	COG2723	6-phospho-beta-galactosidase activity
HB751_RS00775	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HB751_RS00780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB751_RS00780	COG3711	transcriptional antiterminator
HB751_RS00785	COG1447	Phosphotransferase system cellobiose-specific component IIA
HB751_RS00795	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HB751_RS00815	COG1609	Transcriptional regulator
HB751_RS00830	COG0438	transferase activity, transferring glycosyl groups
HB751_RS00845	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HB751_RS00850	COG1956	GAF domain-containing protein
HB751_RS00855	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HB751_RS00880	COG0653	protein targeting
HB751_RS00890	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HB751_RS00895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HB751_RS00900	COG3842	ATPase activity
HB751_RS00905	COG3833	ABC-type maltose transport systems, permease component
HB751_RS00910	COG1175	transmembrane transport
HB751_RS00925	COG1640	4-alpha-glucanotransferase
HB751_RS00930	COG0058	SHG alpha-glucan phosphorylase activity
HB751_RS00935	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HB751_RS00940	COG0569	domain protein
HB751_RS00960	COG4109	DRTGG domain
HB751_RS00990	COG1131	(ABC) transporter
HB751_RS01000	COG4585	Histidine kinase
HB751_RS01005	COG2197	response regulator
HB751_RS01015	COG4708	membrane
HB751_RS01020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HB751_RS01025	COG1597	lipid kinase activity
HB751_RS01030	COG1523	belongs to the glycosyl hydrolase 13 family
HB751_RS01035	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HB751_RS01040	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HB751_RS01045	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HB751_RS01050	COG0297	glycogen (starch) synthase activity
HB751_RS01055	COG0058	SHG alpha-glucan phosphorylase activity
HB751_RS01065	COG0356	it plays a direct role in the translocation of protons across the membrane
HB751_RS01070	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HB751_RS01075	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HB751_RS01080	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HB751_RS01085	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HB751_RS01090	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HB751_RS01095	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HB751_RS01105	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HB751_RS01120	COG0765	amino acid transport
HB751_RS01125	COG0765	amino acid transport
HB751_RS01130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB751_RS01135	COG1126	abc transporter atp-binding protein
HB751_RS01140	COG0745	RESPONSE REGULATOR receiver
HB751_RS01145	COG5002	protein histidine kinase activity
HB751_RS01150	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HB751_RS01155	COG0571	ribonuclease III activity
HB751_RS01160	COG1196	nuclear chromosome segregation
HB751_RS01165	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HB751_RS01175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB751_RS01175	COG0072	phenylalanine-tRNA ligase activity
HB751_RS01180	COG1396	sequence-specific DNA binding
HB751_RS01185	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HB751_RS01215	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HB751_RS01220	COG1074	ATP-dependent DNA helicase activity
HB751_RS01225	COG1349	DNA-binding transcription factor activity
HB751_RS01230	COG0698	ribose 5-phosphate isomerase
HB751_RS01235	COG0698	ribose 5-phosphate isomerase
HB751_RS01240	COG1105	Belongs to the carbohydrate kinase PfkB family
HB751_RS01245	COG3684	Belongs to the aldolase LacD family
HB751_RS01250	COG1447	Phosphotransferase system cellobiose-specific component IIA
HB751_RS01255	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HB751_RS01255	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HB751_RS01260	COG2723	6-phospho-beta-galactosidase activity
HB751_RS01290	COG1401	restriction endodeoxyribonuclease activity
HB751_RS01320	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HB751_RS01335	COG1234	tRNA 3'-trailer cleavage
HB751_RS01340	COG0300	oxidoreductase activity
HB751_RS01345	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HB751_RS01345	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HB751_RS01350	COG2378	regulation of single-species biofilm formation
HB751_RS01370	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HB751_RS01375	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HB751_RS01385	COG2384	SAM-dependent methyltransferase
HB751_RS01395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB751_RS01400	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HB751_RS01415	COG1088	dTDP-glucose 4,6-dehydratase activity
HB751_RS01420	COG1051	belongs to the nudix hydrolase family
HB751_RS01425	COG0628	permease
HB751_RS01435	COG0028	Belongs to the TPP enzyme family
HB751_RS01440	COG3527	Alpha-acetolactate decarboxylase
HB751_RS01445	COG1113	amino acid transport
HB751_RS01450	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HB751_RS01465	COG3842	ATPase activity
HB751_RS01485	COG4808	Protein conserved in bacteria
HB751_RS01495	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HB751_RS01510	COG1215	transferase activity, transferring glycosyl groups
HB751_RS01520	COG0488	(ABC) transporter
HB751_RS01530	COG3442	glutamine amidotransferase
HB751_RS01535	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HB751_RS01540	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HB751_RS01550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB751_RS01555	COG0542	response to heat
HB751_RS01565	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HB751_RS01570	COG0022	dehydrogenase e1 component
HB751_RS01575	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB751_RS01580	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB751_RS01590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HB751_RS01600	COG1051	belongs to the nudix hydrolase family
HB751_RS01605	COG0647	UMP catabolic process
HB751_RS01615	COG1136	(ABC) transporter
HB751_RS01615	COG0577	efflux transmembrane transporter activity
HB751_RS01625	COG3976	FMN-binding domain protein
HB751_RS01625	COG1053	succinate dehydrogenase
HB751_RS01640	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HB751_RS01645	COG1518	maintenance of DNA repeat elements
HB751_RS01650	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HB751_RS01670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HB751_RS01690	COG0481	GTPase activity
HB751_RS01725	COG0673	inositol 2-dehydrogenase activity
HB751_RS01730	COG0572	uridine kinase
HB751_RS01740	COG0473	3-isopropylmalate dehydrogenase activity
HB751_RS01745	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HB751_RS01750	COG0066	3-isopropylmalate dehydratase activity
HB751_RS01765	COG0456	acetyltransferase
HB751_RS01765	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HB751_RS01775	COG2813	Specifically methylates the guanine in position
HB751_RS01785	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HB751_RS01795	COG2884	Cell division ATP-binding protein ftsE
HB751_RS01800	COG2177	Part of the ABC transporter FtsEX involved in
HB751_RS01840	COG1122	ATPase activity
HB751_RS01855	COG0436	Aminotransferase
HB751_RS01860	COG0017	Asparaginyl-tRNA synthetase
HB751_RS01865	COG0371	Dehydrogenase
HB751_RS01870	COG0251	oxidation-reduction process
HB751_RS01880	COG1660	Displays ATPase and GTPase activities
HB751_RS01890	COG1481	regulation of sporulation
HB751_RS01905	COG2226	methyltransferase
HB751_RS01920	COG0254	rRNA binding
HB751_RS01925	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HB751_RS01930	COG0625	glutathione transferase activity
HB751_RS01935	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HB751_RS01940	COG0716	FMN binding
HB751_RS01955	COG0077	Prephenate dehydratase
HB751_RS01955	COG1605	Chorismate mutase
HB751_RS01960	COG0038	chloride channel
HB751_RS01965	COG0038	chloride channel
HB751_RS01970	COG0335	large ribosomal subunit rRNA binding
HB751_RS01980	COG2814	Major facilitator Superfamily
HB751_RS02005	COG0772	Belongs to the SEDS family
HB751_RS02020	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HB751_RS02030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HB751_RS02035	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HB751_RS02040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HB751_RS02045	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HB751_RS02050	COG0560	Phosphoserine phosphatase
HB751_RS02055	COG0131	Imidazoleglycerol-phosphate dehydratase
HB751_RS02065	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HB751_RS02070	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HB751_RS02075	COG0107	imidazoleglycerol-phosphate synthase activity
HB751_RS02080	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HB751_RS02190	COG0148	phosphopyruvate hydratase activity
HB751_RS02200	COG1011	Hydrolase
HB751_RS02210	COG0322	excinuclease ABC activity
HB751_RS02220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HB751_RS02225	COG1573	uracil-dna glycosylase
HB751_RS02245	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HB751_RS02250	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HB751_RS02255	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HB751_RS02285	COG0813	purine-nucleoside phosphorylase activity
HB751_RS02300	COG0543	2 iron, 2 sulfur cluster binding
HB751_RS02305	COG0167	dihydroorotate dehydrogenase activity
HB751_RS02310	COG0284	orotidine-5'-phosphate decarboxylase activity
HB751_RS02315	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HB751_RS02320	COG1881	PFAM PEBP family protein
HB751_RS02325	COG2315	Protein conserved in bacteria
HB751_RS02335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB751_RS02340	COG0765	amino acid transport
HB751_RS02345	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HB751_RS02355	COG0737	Belongs to the 5'-nucleotidase family
HB751_RS02360	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HB751_RS02365	COG0187	DNA topoisomerase II activity
HB751_RS02380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HB751_RS02400	COG0539	negative regulation of cytoplasmic translation
HB751_RS02430	COG1131	(ABC) transporter
HB751_RS02435	COG1725	Transcriptional regulator
HB751_RS02445	COG0205	6-phosphofructokinase activity
HB751_RS02450	COG0469	pyruvate kinase activity
HB751_RS02455	COG2261	transglycosylase associated protein
HB751_RS02465	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HB751_RS02470	COG2213	PTS system mannitol-specific
HB751_RS02475	COG3711	transcriptional antiterminator
HB751_RS02480	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB751_RS02485	COG0246	Mannitol dehydrogenase
HB751_RS02490	COG2824	Alkylphosphonate utilization operon protein PhnA
HB751_RS02495	COG0765	amino acid transport
HB751_RS02500	COG1126	abc transporter atp-binding protein
HB751_RS02505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB751_RS02510	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HB751_RS02515	COG1115	amino acid carrier protein
HB751_RS02520	COG0210	DNA helicase
HB751_RS02525	COG2873	o-acetylhomoserine
HB751_RS02540	COG0785	Cytochrome C biogenesis protein
HB751_RS02545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HB751_RS02580	COG1132	(ABC) transporter
HB751_RS02645	COG0745	RESPONSE REGULATOR receiver
HB751_RS02650	COG2205	protein histidine kinase activity
HB751_RS02655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HB751_RS02660	COG0196	riboflavin kinase activity
HB751_RS02665	COG1393	Belongs to the ArsC family
HB751_RS02670	COG4476	Belongs to the UPF0223 family
HB751_RS02675	COG0483	inositol monophosphate 1-phosphatase activity
HB751_RS02680	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HB751_RS02680	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HB751_RS02690	COG0573	inorganic phosphate transmembrane transporter activity
HB751_RS02695	COG0581	inorganic phosphate transmembrane transporter activity
HB751_RS02700	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HB751_RS02705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HB751_RS02710	COG0704	Plays a role in the regulation of phosphate uptake
HB751_RS02725	COG0745	RESPONSE REGULATOR receiver
HB751_RS02730	COG5002	protein histidine kinase activity
HB751_RS02735	COG0268	Binds directly to 16S ribosomal RNA
HB751_RS02740	COG1072	(Pantothenic acid kinase))
HB751_RS02745	COG2813	Specifically methylates the guanine in position
HB751_RS02750	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HB751_RS02755	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HB751_RS02760	COG0295	cytidine deaminase activity
HB751_RS02765	COG1744	ABC transporter substrate-binding protein PnrA-like
HB751_RS02795	COG0039	L-malate dehydrogenase activity
HB751_RS02805	COG3764	Sortase (surface protein transpeptidase)
HB751_RS02810	COG0346	lactoylglutathione lyase activity
HB751_RS02825	COG0561	phosphatase activity
HB751_RS02855	COG2723	6-phospho-beta-galactosidase activity
HB751_RS02860	COG0628	permease
HB751_RS02880	COG1174	glycine betaine transport
HB751_RS02885	COG1136	(ABC) transporter
HB751_RS02890	COG0577	efflux transmembrane transporter activity
HB751_RS02900	COG3976	FMN-binding domain protein
HB751_RS02900	COG1053	succinate dehydrogenase
HB751_RS02900	COG0431	NADPH-dependent FMN reductase
HB751_RS02915	COG1942	4-Oxalocrotonate Tautomerase
HB751_RS02920	COG1435	thymidine kinase activity
HB751_RS02925	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HB751_RS02930	COG2890	protein-(glutamine-N5) methyltransferase activity
HB751_RS02935	COG0009	L-threonylcarbamoyladenylate synthase
HB751_RS02940	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HB751_RS02955	COG1132	(ABC) transporter
HB751_RS02960	COG1132	(ABC) transporter
HB751_RS02965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB751_RS02970	COG4684	Psort location CytoplasmicMembrane, score
HB751_RS02975	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HB751_RS02985	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HB751_RS02990	COG1247	-acetyltransferase
HB751_RS03010	COG1131	(ABC) transporter
HB751_RS03085	COG0519	Catalyzes the synthesis of GMP from XMP
HB751_RS03090	COG2188	Transcriptional regulator
HB751_RS03100	COG4175	Glycine betaine
HB751_RS03100	COG3448	diguanylate cyclase activity
HB751_RS03110	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HB751_RS03115	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HB751_RS03140	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HB751_RS03145	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HB751_RS03155	COG1104	cysteine desulfurase activity
HB751_RS03160	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HB751_RS03165	COG4116	CYTH
HB751_RS03175	COG2357	RelA SpoT domain protein
HB751_RS03180	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HB751_RS03185	COG0564	pseudouridine synthase activity
HB751_RS03190	COG0280	phosphate acetyltransferase
HB751_RS03200	COG1131	(ABC) transporter
HB751_RS03205	COG4221	oxidoreductase activity
HB751_RS03210	COG1442	glycosyl transferase family 8
HB751_RS03215	COG0745	RESPONSE REGULATOR receiver
HB751_RS03220	COG5002	protein histidine kinase activity
HB751_RS03230	COG1131	(ABC) transporter
HB751_RS03235	COG4974	Belongs to the 'phage' integrase family
HB751_RS03270	COG3052	prosthetic group binding
HB751_RS03275	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HB751_RS03280	COG0511	ligase activity, forming carbon-carbon bonds
HB751_RS03290	COG2851	Citrate transporter
HB751_RS03300	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HB751_RS03305	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HB751_RS03310	COG0642	Histidine kinase
HB751_RS03315	COG0745	RESPONSE REGULATOR receiver
HB751_RS03325	COG1136	(ABC) transporter
HB751_RS03330	COG0366	Alpha amylase catalytic
HB751_RS03330	COG5263	repeat protein
HB751_RS03335	COG0366	Alpha amylase catalytic
HB751_RS03335	COG5263	repeat protein
HB751_RS03340	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HB751_RS03345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HB751_RS03350	COG0758	DNA mediated transformation
HB751_RS03360	COG4607	ABC-type enterochelin transport system periplasmic component
HB751_RS03365	COG4604	ABC transporter, ATP-binding protein
HB751_RS03370	COG4605	iron ion homeostasis
HB751_RS03375	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB751_RS03380	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HB751_RS03385	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HB751_RS03400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB751_RS03405	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HB751_RS03415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HB751_RS03420	COG4932	domain protein
HB751_RS03450	COG1263	PTS System
HB751_RS03450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HB751_RS03450	COG2190	(PTS) system
HB751_RS03455	COG3711	transcriptional antiterminator
HB751_RS03465	COG1177	transmembrane transport
HB751_RS03470	COG1176	ABC-type spermidine putrescine transport system, permease component I
HB751_RS03475	COG3842	ATPase activity
HB751_RS03480	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HB751_RS03500	COG0302	gtp cyclohydrolase
HB751_RS03505	COG0285	dihydrofolate synthase activity
HB751_RS03510	COG0083	homoserine kinase activity
HB751_RS03520	COG0726	polysaccharide deacetylase
HB751_RS03525	COG1960	acyl-CoA dehydrogenase activity
HB751_RS03535	COG0222	ribosome binding
HB751_RS03540	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HB751_RS03565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB751_RS03570	COG2040	homocysteine
HB751_RS03575	COG0833	amino acid
HB751_RS03580	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HB751_RS03585	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HB751_RS03595	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HB751_RS03600	COG3201	nicotinamide mononucleotide transporter
HB751_RS03605	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HB751_RS03610	COG3425	synthase
HB751_RS03625	COG1272	protein, Hemolysin III
HB751_RS03630	COG1304	FMN binding
HB751_RS03645	COG1126	abc transporter atp-binding protein
HB751_RS03650	COG0765	amino acid transport
HB751_RS03655	COG0765	amino acid transport
HB751_RS03660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB751_RS03670	COG0583	DNA-binding transcription factor activity
HB751_RS03675	COG3759	membrane
HB751_RS03685	COG0745	RESPONSE REGULATOR receiver
HB751_RS03690	COG2357	RelA SpoT domain protein
HB751_RS03700	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HB751_RS03705	COG1132	(ABC) transporter
HB751_RS03720	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HB751_RS03730	COG0602	queuosine metabolic process
HB751_RS03735	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HB751_RS03745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HB751_RS03755	COG0366	Alpha amylase catalytic
HB751_RS03755	COG5263	repeat protein
HB751_RS03775	COG0488	(ABC) transporter
HB751_RS03780	COG0617	tRNA 3'-terminal CCA addition
HB751_RS03785	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HB751_RS03790	COG1307	EDD domain protein, DegV family
HB751_RS03805	COG1131	(ABC) transporter
HB751_RS03825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB751_RS03830	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HB751_RS03835	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HB751_RS03840	COG1609	Transcriptional regulator
HB751_RS03845	COG0366	Alpha amylase catalytic
HB751_RS03850	COG3842	ATPase activity
HB751_RS03855	COG0366	Alpha amylase catalytic
HB751_RS03860	COG0395	ABC-type sugar transport system, permease component
HB751_RS03865	COG1175	transmembrane transport
HB751_RS03870	COG1653	transport
HB751_RS03875	COG3345	alpha-galactosidase
HB751_RS03880	COG2207	Transcriptional regulator
HB751_RS03890	COG2801	Transposase and inactivated derivatives
HB751_RS03895	COG0646	methionine synthase
HB751_RS03895	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HB751_RS03900	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HB751_RS03905	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB751_RS03905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB751_RS03905	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB751_RS03910	COG1105	Belongs to the carbohydrate kinase PfkB family
HB751_RS03915	COG1349	DNA-binding transcription factor activity
HB751_RS03920	COG0492	ferredoxin-NADP+ reductase activity
HB751_RS03925	COG0336	Belongs to the RNA methyltransferase TrmD family
HB751_RS03930	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HB751_RS03935	COG1837	Belongs to the UPF0109 family
HB751_RS03940	COG0228	four-way junction DNA binding
HB751_RS03945	COG0577	efflux transmembrane transporter activity
HB751_RS03950	COG1136	(ABC) transporter
HB751_RS03960	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HB751_RS03965	COG0505	Belongs to the CarA family
HB751_RS03970	COG0540	Belongs to the ATCase OTCase family
HB751_RS03980	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HB751_RS03990	COG0564	pseudouridine synthase activity
HB751_RS03995	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HB751_RS04000	COG0583	DNA-binding transcription factor activity
HB751_RS04005	COG2816	NAD+ diphosphatase activity
HB751_RS04015	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HB751_RS04025	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HB751_RS04045	COG0301	tRNA thio-modification
HB751_RS04050	COG1104	cysteine desulfurase activity
HB751_RS04060	COG0285	dihydrofolate synthase activity
HB751_RS04065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB751_RS04070	COG0656	L-ascorbic acid biosynthetic process
HB751_RS04075	COG3942	CHAP domain
HB751_RS04090	COG0463	Glycosyl transferase, family 2
HB751_RS04100	COG1368	sulfuric ester hydrolase activity
HB751_RS04125	COG1215	transferase activity, transferring glycosyl groups
HB751_RS04135	COG1091	dTDP-4-dehydrorhamnose reductase activity
HB751_RS04140	COG2151	metal-sulfur cluster biosynthetic enzyme
HB751_RS04145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HB751_RS04150	COG0358	DNA primase activity
HB751_RS04160	COG1970	mechanosensitive ion channel activity
HB751_RS04170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB751_RS04180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB751_RS04185	COG1051	belongs to the nudix hydrolase family
HB751_RS04205	COG0556	nucleotide-excision repair
HB751_RS04220	COG1126	abc transporter atp-binding protein
HB751_RS04225	COG0488	(ABC) transporter
HB751_RS04235	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HB751_RS04290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HB751_RS04300	COG0077	Prephenate dehydratase
HB751_RS04305	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HB751_RS04310	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HB751_RS04315	COG3679	Belongs to the UPF0342 family
HB751_RS04320	COG0287	Prephenate dehydrogenase
HB751_RS04325	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HB751_RS04330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HB751_RS04335	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HB751_RS04340	COG0710	3-dehydroquinate dehydratase activity
HB751_RS04345	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HB751_RS04350	COG1368	sulfuric ester hydrolase activity
HB751_RS04370	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HB751_RS04375	COG0366	Alpha amylase catalytic
HB751_RS04375	COG5263	repeat protein
HB751_RS04380	COG1914	H( )-stimulated, divalent metal cation uptake system
HB751_RS04385	COG4443	Transcriptional Coactivator p15 (PC4)
HB751_RS04405	COG0450	alkyl hydroperoxide reductase
HB751_RS04435	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HB751_RS04440	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HB751_RS04450	COG3091	SprT-like family
HB751_RS04455	COG2183	response to ionizing radiation
HB751_RS04460	COG0701	Predicted permease
HB751_RS04465	COG3689	TIGRFAM TIGR03943 family protein
HB751_RS04470	COG0477	Major facilitator Superfamily
HB751_RS04475	COG0552	protein localization to endoplasmic reticulum
HB751_RS04480	COG0561	phosphatase activity
HB751_RS04485	COG0561	phosphatase activity
HB751_RS04525	COG1131	(ABC) transporter
HB751_RS04535	COG0604	alcohol dehydrogenase
HB751_RS04550	COG0584	glycerophosphoryl diester phosphodiesterase
HB751_RS04570	COG1078	dGTPase activity
HB751_RS04590	COG0149	triose-phosphate isomerase activity
HB751_RS04595	COG2274	protein secretion by the type I secretion system
HB751_RS04630	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HB751_RS04635	COG0772	Belongs to the SEDS family
HB751_RS04640	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HB751_RS04660	COG3859	Proton-coupled thiamine transporter YuaJ
HB751_RS04675	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HB751_RS04685	COG0406	alpha-ribazole phosphatase activity
HB751_RS04690	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HB751_RS04695	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HB751_RS04700	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HB751_RS04705	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HB751_RS04725	COG2195	Cleaves the N-terminal amino acid of tripeptides
HB751_RS04760	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HB751_RS04780	COG0656	L-ascorbic acid biosynthetic process
HB751_RS04785	COG0789	Transcriptional regulator
HB751_RS04790	COG1012	belongs to the aldehyde dehydrogenase family
HB751_RS04795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HB751_RS04800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB751_RS04810	COG0538	isocitrate dehydrogenase activity
HB751_RS04815	COG0372	Belongs to the citrate synthase family
HB751_RS04820	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HB751_RS04825	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HB751_RS04830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HB751_RS04840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB751_RS04845	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HB751_RS04850	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HB751_RS04855	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HB751_RS04895	COG1131	(ABC) transporter
HB751_RS04915	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HB751_RS04925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HB751_RS04930	COG4122	O-methyltransferase activity
HB751_RS04935	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HB751_RS04935	COG0131	Imidazoleglycerol-phosphate dehydratase
HB751_RS04965	COG1028	Short-chain dehydrogenase reductase Sdr
HB751_RS04965	COG3321	synthase
HB751_RS04965	COG0604	alcohol dehydrogenase
HB751_RS04970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB751_RS04980	COG1187	pseudouridine synthase activity
HB751_RS04990	COG0363	glucosamine-6-phosphate deaminase activity
HB751_RS05000	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HB751_RS05025	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HB751_RS05045	COG0658	competence protein
HB751_RS05045	COG2333	competence protein COMEC
HB751_RS05050	COG1596	polysaccharide export
HB751_RS05050	COG1555	photosystem II stabilization
HB751_RS05055	COG0204	Acyl-transferase
HB751_RS05060	COG0726	polysaccharide deacetylase
HB751_RS05070	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HB751_RS05095	COG0513	Belongs to the DEAD box helicase family
HB751_RS05100	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HB751_RS05100	COG3064	Membrane
HB751_RS05110	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HB751_RS05120	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HB751_RS05125	COG0385	Bile acid
HB751_RS05135	COG1181	Belongs to the D-alanine--D-alanine ligase family
HB751_RS05140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HB751_RS05145	COG0768	penicillin binding
HB751_RS05150	COG0588	phosphoglycerate mutase activity
HB751_RS05165	COG0735	belongs to the Fur family
HB751_RS05180	COG2801	Transposase and inactivated derivatives
HB751_RS05185	COG0776	regulation of translation
HB751_RS05195	COG2755	lipolytic protein G-D-S-L family
HB751_RS05200	COG1307	EDD domain protein, DegV family
HB751_RS05205	COG0497	DNA recombination
HB751_RS05210	COG1438	arginine binding
HB751_RS05215	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HB751_RS05225	COG1722	exodeoxyribonuclease VII activity
HB751_RS05230	COG1570	exodeoxyribonuclease VII activity
HB751_RS05235	COG3275	phosphorelay sensor kinase activity
HB751_RS05240	COG3279	Response regulator of the LytR AlgR family
HB751_RS05245	COG1380	Effector of murein hydrolase LrgA
HB751_RS05250	COG1346	cytolysis
HB751_RS05255	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HB751_RS05260	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HB751_RS05280	COG1126	abc transporter atp-binding protein
HB751_RS05285	COG0765	amino acid transport
HB751_RS05290	COG4703	Protein of unknown function (DUF1797)
HB751_RS05295	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HB751_RS05300	COG0542	response to heat
HB751_RS05315	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HB751_RS05320	COG3599	regulation of cell shape
HB751_RS05325	COG2302	S4 RNA-binding domain
HB751_RS05335	COG1799	cell septum assembly
HB751_RS05340	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HB751_RS05350	COG0849	cell division
HB751_RS05360	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HB751_RS05365	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HB751_RS05380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HB751_RS05385	COG1940	carbohydrate kinase activity
HB751_RS05395	COG0783	Belongs to the Dps family
HB751_RS05405	COG0159	tryptophan synthase activity
HB751_RS05410	COG0133	tryptophan synthase activity
HB751_RS05415	COG0135	phosphoribosylanthranilate isomerase activity
HB751_RS05420	COG0134	indole-3-glycerol-phosphate synthase activity
HB751_RS05425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HB751_RS05430	COG0512	Glutamine amidotransferase of anthranilate synthase
HB751_RS05435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HB751_RS05455	COG3804	dihydrodipicolinate reductase
HB751_RS05465	COG1132	(ABC) transporter
HB751_RS05470	COG1132	(ABC) transporter
HB751_RS05480	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HB751_RS05485	COG4470	Protein conserved in bacteria
HB751_RS05490	COG0737	Belongs to the 5'-nucleotidase family
HB751_RS05495	COG3480	Lon protease (S16) C-terminal proteolytic domain
HB751_RS05500	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HB751_RS05505	COG0742	ribosomal rna small subunit methyltransferase
HB751_RS05510	COG4716	Myosin-crossreactive antigen
HB751_RS05550	COG0561	phosphatase activity
HB751_RS05555	COG1349	DNA-binding transcription factor activity
HB751_RS05600	COG1040	competence protein
HB751_RS05605	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HB751_RS05610	COG1739	Uncharacterized protein family UPF0029
HB751_RS05630	COG1882	Formate acetyltransferase
HB751_RS05635	COG1349	DNA-binding transcription factor activity
HB751_RS05640	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HB751_RS05645	COG1098	S1 RNA binding domain
HB751_RS05655	COG2197	response regulator
HB751_RS05660	COG4585	Histidine kinase
HB751_RS05680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HB751_RS05680	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HB751_RS05685	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HB751_RS05690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HB751_RS05695	COG1758	RNA polymerase activity
HB751_RS05700	COG0194	GDP metabolic process
HB751_RS05705	COG1418	mRNA catabolic process
HB751_RS05705	COG4372	Transposase
HB751_RS05710	COG1854	S-ribosylhomocysteine lyase activity
HB751_RS05720	COG0116	Belongs to the methyltransferase superfamily
HB751_RS05730	COG3599	regulation of cell shape
HB751_RS05735	COG4474	Belongs to the UPF0398 family
HB751_RS05740	COG3331	DNA recombination
HB751_RS05745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HB751_RS05750	COG3579	cysteine-type endopeptidase activity
HB751_RS05755	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HB751_RS05760	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HB751_RS05765	COG0492	ferredoxin-NADP+ reductase activity
HB751_RS05775	COG1126	abc transporter atp-binding protein
HB751_RS05790	COG0513	Belongs to the DEAD box helicase family
HB751_RS05800	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HB751_RS05805	COG0768	penicillin binding
HB751_RS05810	COG4839	cell division protein FtsL
HB751_RS05815	COG0275	rRNA processing
HB751_RS05820	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HB751_RS05825	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HB751_RS05835	COG4224	UPF0291 protein
HB751_RS05840	COG0751	glycine-tRNA ligase activity
HB751_RS05845	COG0752	glycyl-tRNA synthetase alpha subunit
HB751_RS05850	COG1673	EVE domain
HB751_RS05870	COG1924	4 iron, 4 sulfur cluster binding
HB751_RS05905	COG0561	phosphatase activity
HB751_RS05915	COG2217	Heavy metal translocating P-type atpase
HB751_RS05935	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HB751_RS05940	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HB751_RS05950	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HB751_RS05955	COG0195	Participates in both transcription termination and antitermination
HB751_RS05960	COG0779	Required for maturation of 30S ribosomal subunits
HB751_RS05970	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HB751_RS05980	COG4473	ABC transporter
HB751_RS05985	COG1131	(ABC) transporter
HB751_RS05990	COG0537	adenosine 5'-monophosphoramidase activity
HB751_RS06000	COG1316	TRANSCRIPTIONal
HB751_RS06005	COG0802	atpase or kinase
HB751_RS06010	COG2252	PERMEase
HB751_RS06020	COG0561	phosphatase activity
HB751_RS06035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HB751_RS06040	COG1882	Formate acetyltransferase
HB751_RS06050	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HB751_RS06065	COG2936	dipeptidyl-peptidase activity
HB751_RS06115	COG0582	viral genome integration into host DNA
HB751_RS06120	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HB751_RS06130	COG2081	HI0933 family
HB751_RS06150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HB751_RS06155	COG0456	acetyltransferase
HB751_RS06160	COG1214	PFAM Peptidase M22, glycoprotease
HB751_RS06170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB751_RS06175	COG0667	Aldo Keto reductase
HB751_RS06205	COG3942	CHAP domain
HB751_RS06210	COG0493	'glutamate synthase
HB751_RS06215	COG0070	glutamate synthase
HB751_RS06215	COG0067	glutamate synthase
HB751_RS06215	COG0069	glutamate synthase activity
HB751_RS06220	COG0174	glutamine synthetase
HB751_RS06225	COG0789	Transcriptional regulator
HB751_RS06235	COG0126	phosphoglycerate kinase activity
HB751_RS06245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HB751_RS06250	COG0049	tRNA binding
HB751_RS06255	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HB751_RS06260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HB751_RS06285	COG1162	GTPase activity
HB751_RS06305	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HB751_RS06340	COG0084	hydrolase, TatD family'
HB751_RS06345	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HB751_RS06360	COG0706	membrane insertase activity
HB751_RS06365	COG0594	ribonuclease P activity
HB751_RS06370	COG0165	Argininosuccinate lyase
HB751_RS06375	COG0137	argininosuccinate synthase activity
HB751_RS06390	COG1827	regulation of RNA biosynthetic process
HB751_RS06395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HB751_RS06420	COG0756	dUTP diphosphatase activity
HB751_RS06425	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HB751_RS06430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HB751_RS06435	COG0457	Tetratricopeptide repeat
HB751_RS06435	COG0705	Rhomboid family
HB751_RS06440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HB751_RS06445	COG1473	amidohydrolase
HB751_RS06450	COG2171	N-acyltransferase activity
HB751_RS06465	COG3732	PTS system glucitol sorbitol-specific
HB751_RS06470	COG3730	PTS system glucitol sorbitol-specific
HB751_RS06480	COG3711	transcriptional antiterminator
HB751_RS06480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB751_RS06490	COG0166	Belongs to the GPI family
HB751_RS06505	COG1028	Short-chain dehydrogenase reductase Sdr
HB751_RS06510	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HB751_RS06530	COG1136	(ABC) transporter
HB751_RS06550	COG1131	(ABC) transporter
HB751_RS06560	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HB751_RS06600	COG1234	tRNA 3'-trailer cleavage
HB751_RS06615	COG0343	queuine tRNA-ribosyltransferase activity
HB751_RS06625	COG1832	CoA-binding protein
HB751_RS06630	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HB751_RS06630	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HB751_RS06645	COG0583	DNA-binding transcription factor activity
HB751_RS06675	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HB751_RS06695	COG2274	protein secretion by the type I secretion system
HB751_RS06745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB751_RS06760	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HB751_RS06765	COG2918	glutathione biosynthetic process
HB751_RS06765	COG1181	Belongs to the D-alanine--D-alanine ligase family
HB751_RS06775	COG4608	Belongs to the ABC transporter superfamily
HB751_RS06780	COG0444	Belongs to the ABC transporter superfamily
HB751_RS06785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB751_RS06790	COG0601	transmembrane transport
HB751_RS06795	COG4166	transmembrane transport
HB751_RS06810	COG0719	Fe-S assembly protein
HB751_RS06820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HB751_RS06825	COG0719	Fe-S assembly protein
HB751_RS06835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HB751_RS06840	COG4862	establishment of competence for transformation
HB751_RS06845	COG1968	undecaprenyl-diphosphatase activity
HB751_RS06855	COG0765	amino acid transport
HB751_RS06860	COG1126	abc transporter atp-binding protein
HB751_RS06870	COG1131	(ABC) transporter
HB751_RS06880	COG1309	transcriptional regulator
HB751_RS06890	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HB751_RS06895	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HB751_RS06900	COG0440	acetolactate synthase activity
HB751_RS06905	COG0028	Belongs to the TPP enzyme family
HB751_RS07025	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HB751_RS07030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HB751_RS07040	COG0803	Belongs to the bacterial solute-binding protein 9 family
HB751_RS07055	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HB751_RS07060	COG0431	NADPH-dependent FMN reductase
HB751_RS07060	COG1053	succinate dehydrogenase
HB751_RS07060	COG3976	FMN-binding domain protein
HB751_RS07065	COG3976	FMN-binding domain protein
HB751_RS07065	COG0431	NADPH-dependent FMN reductase
HB751_RS07065	COG1053	succinate dehydrogenase
HB751_RS07075	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HB751_RS07115	COG0640	Transcriptional regulator
HB751_RS07120	COG0697	spore germination
HB751_RS07135	COG0473	3-isopropylmalate dehydrogenase activity
HB751_RS07135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HB751_RS07140	COG0473	3-isopropylmalate dehydrogenase activity
HB751_RS07140	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HB751_RS07160	COG0640	Transcriptional regulator
HB751_RS07205	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HB751_RS07210	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HB751_RS07215	COG1476	TRANSCRIPTIONal
HB751_RS07235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HB751_RS07255	COG5504	Zn-dependent protease
HB751_RS07260	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HB751_RS07265	COG0215	cysteine-tRNA ligase activity
HB751_RS07270	COG1045	serine acetyltransferase
HB751_RS07280	COG1185	polyribonucleotide nucleotidyltransferase activity
HB751_RS07285	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HB751_RS07290	COG1454	alcohol dehydrogenase
HB751_RS07290	COG1012	belongs to the aldehyde dehydrogenase family
HB751_RS07300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB751_RS07305	COG0242	peptide deformylase activity
HB751_RS07320	COG2140	Oxalate decarboxylase
HB751_RS07325	COG0679	Auxin Efflux Carrier
HB751_RS07330	COG0281	malic enzyme
HB751_RS07340	COG0583	DNA-binding transcription factor activity
HB751_RS07345	COG1309	transcriptional regulator
HB751_RS07350	COG0477	Major facilitator Superfamily
HB751_RS07355	COG1473	amidohydrolase
HB751_RS07360	COG0095	Lipoate-protein ligase
HB751_RS07375	COG0022	dehydrogenase e1 component
HB751_RS07375	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB751_RS07380	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HB751_RS07385	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HB751_RS07390	COG1846	Transcriptional regulator
HB751_RS07395	COG2176	DNA-directed DNA polymerase activity
HB751_RS07400	COG0534	Mate efflux family protein
HB751_RS07405	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HB751_RS07410	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HB751_RS07415	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HB751_RS07425	COG3684	Belongs to the aldolase LacD family
HB751_RS07430	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB751_RS07430	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB751_RS07430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB751_RS07435	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB751_RS07435	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB751_RS07435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB751_RS07440	COG1105	Belongs to the carbohydrate kinase PfkB family
HB751_RS07450	COG1396	sequence-specific DNA binding
HB751_RS07500	COG3715	PTS system
HB751_RS07510	COG0191	fructose-bisphosphate aldolase activity
HB751_RS07530	COG0504	CTP synthase activity
HB751_RS07535	COG3343	RNA polymerase activity
HB751_RS07545	COG0544	peptidyl-prolyl cis-trans isomerase activity
HB751_RS07555	COG0668	transmembrane transport
HB751_RS07560	COG4475	Protein of unknown function (DUF436)
HB751_RS07565	COG4720	Psort location CytoplasmicMembrane, score
HB751_RS07570	COG0351	phosphomethylpyrimidine kinase
HB751_RS07575	COG0101	tRNA pseudouridine synthase activity
HB751_RS07580	COG0484	heat shock protein binding
HB751_RS07585	COG0443	Heat shock 70 kDa protein
HB751_RS07590	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HB751_RS07595	COG1420	regulation of RNA biosynthetic process
HB751_RS07605	COG5492	domain, Protein
HB751_RS07605	COG1621	beta-fructofuranosidase activity
HB751_RS07605	COG3583	domain protein
HB751_RS07610	COG1705	Flagellar rod assembly protein muramidase FlgJ
HB751_RS07625	COG2848	UPF0210 protein
HB751_RS07630	COG3830	Belongs to the UPF0237 family
HB751_RS07635	COG0534	Mate efflux family protein
HB751_RS07655	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HB751_RS07660	COG2255	four-way junction helicase activity
HB751_RS07680	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HB751_RS07695	COG1794	racemase activity, acting on amino acids and derivatives
HB751_RS07710	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HB751_RS07720	COG0151	Belongs to the GarS family
HB751_RS07760	COG0138	bifunctional purine biosynthesis protein purh
HB751_RS07765	COG2176	DNA-directed DNA polymerase activity
HB751_RS07770	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HB751_RS07775	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HB751_RS07780	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HB751_RS07790	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HB751_RS07795	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HB751_RS07800	COG2274	protein secretion by the type I secretion system
HB751_RS07805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB751_RS07810	COG0416	fatty acid biosynthetic process
HB751_RS07815	COG1381	Involved in DNA repair and RecF pathway recombination
HB751_RS07820	COG0436	Aminotransferase
HB751_RS07825	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HB751_RS07830	COG3942	CHAP domain
HB751_RS07840	COG1792	Involved in formation and maintenance of cell shape
HB751_RS07950	COG0531	amino acid
HB751_RS07955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HB751_RS07965	COG0037	tRNA processing
HB751_RS07985	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HB751_RS07990	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HB751_RS07995	COG0193	aminoacyl-tRNA hydrolase activity
HB751_RS08000	COG0012	GTP binding
HB751_RS08010	COG0592	DNA-directed DNA polymerase activity
HB751_RS08015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HB751_RS08020	COG1475	DNA binding
HB751_RS08025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB751_RS08030	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HB751_RS08060	COG0488	(ABC) transporter
HB751_RS08065	COG0180	Tryptophanyl-tRNA synthetase
HB751_RS08070	COG0516	GMP reductase activity
HB751_RS08070	COG0517	IMP dehydrogenase activity
HB751_RS08075	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HB751_RS08090	COG0612	Peptidase, M16
HB751_RS08100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HB751_RS08105	COG1122	ATPase activity
HB751_RS08110	COG1122	ATPase activity
HB751_RS08115	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HB751_RS08125	COG0741	lytic transglycosylase activity
HB751_RS08130	COG0482	sulfurtransferase activity
HB751_RS08140	COG0445	tRNA wobble uridine modification
HB751_RS08150	COG0359	binds to the 23S rRNA
HB751_RS08155	COG0305	Participates in initiation and elongation during chromosome replication
HB751_RS08165	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HB751_RS08185	COG2151	metal-sulfur cluster biosynthetic enzyme
HB751_RS08190	COG0129	dihydroxy-acid dehydratase activity
HB751_RS08195	COG1012	belongs to the aldehyde dehydrogenase family
HB751_RS08220	COG2094	Belongs to the DNA glycosylase MPG family
HB751_RS08245	COG1028	Short-chain dehydrogenase reductase Sdr
HB751_RS08250	COG0789	Transcriptional regulator
HB751_RS08275	COG0640	Transcriptional regulator
HB751_RS08290	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HB751_RS08295	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HB751_RS08300	COG0531	amino acid
HB751_RS08305	COG0124	histidyl-tRNA synthetase
HB751_RS08310	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HB751_RS08315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HB751_RS08320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HB751_RS08325	COG0018	arginyl-trna synthetase
HB751_RS08345	COG1438	arginine binding
HB751_RS08355	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HB751_RS08365	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HB751_RS08370	COG0632	four-way junction helicase activity
HB751_RS08375	COG0519	Catalyzes the synthesis of GMP from XMP
HB751_RS08380	COG1058	Belongs to the CinA family
HB751_RS08380	COG1546	Belongs to the CinA family
HB751_RS08385	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HB751_RS08390	COG1393	Belongs to the ArsC family
HB751_RS08415	COG4472	Bacterial protein of unknown function (DUF965)
HB751_RS08420	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HB751_RS08425	COG3906	Belongs to the UPF0473 family
HB751_RS08475	COG0463	Glycosyl transferase, family 2
HB751_RS08485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB751_RS08505	COG0583	DNA-binding transcription factor activity
HB751_RS08510	COG2855	membrane
HB751_RS08520	COG2217	Heavy metal translocating P-type atpase
HB751_RS08535	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HB751_RS08555	COG2264	protein methyltransferase activity
HB751_RS08560	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HB751_RS08575	COG1263	PTS System
HB751_RS08575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HB751_RS08575	COG2190	(PTS) system
HB751_RS08590	COG1490	D-aminoacyl-tRNA deacylase activity
HB751_RS08595	COG5297	Belongs to the glycosyl hydrolase family 6
HB751_RS08605	COG2188	Transcriptional regulator
HB751_RS08610	COG1263	PTS System
HB751_RS08610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HB751_RS08615	COG0366	Alpha amylase catalytic
HB751_RS08625	COG3590	peptidase
HB751_RS08630	COG1619	proteins homologs of microcin C7 resistance protein MccF
HB751_RS08645	COG0052	Belongs to the universal ribosomal protein uS2 family
HB751_RS08650	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HB751_RS08670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB751_RS08695	COG0477	Major facilitator Superfamily
HB751_RS08705	COG4463	regulation of RNA biosynthetic process
HB751_RS08710	COG0542	response to heat
HB751_RS08715	COG1621	beta-fructofuranosidase activity
HB751_RS08725	COG0051	transcription antitermination factor activity, RNA binding
HB751_RS08730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HB751_RS08740	COG0089	rRNA binding
HB751_RS08745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HB751_RS08755	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HB751_RS08760	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HB751_RS08765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HB751_RS08770	COG0255	Belongs to the universal ribosomal protein uL29 family
HB751_RS08775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HB751_RS08780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HB751_RS08785	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HB751_RS08790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HB751_RS08795	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HB751_RS08800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HB751_RS08805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HB751_RS08815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HB751_RS08820	COG1841	ribosomal large subunit assembly
HB751_RS08825	COG0200	Binds to the 23S rRNA
HB751_RS08830	COG0201	protein transport
HB751_RS08835	COG0563	adenylate kinase activity
HB751_RS08840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HB751_RS08850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HB751_RS08855	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HB751_RS08860	COG0202	RNA polymerase activity
HB751_RS08865	COG0203	ribosomal protein L17
HB751_RS08905	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HB751_RS08915	COG1121	(ABC) transporter
HB751_RS08920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HB751_RS08925	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HB751_RS08930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HB751_RS08935	COG0085	RNA polymerase activity
HB751_RS08940	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HB751_RS08950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HB751_RS08955	COG1459	type II secretion system
HB751_RS08985	COG0827	DNA restriction-modification system
HB751_RS08990	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HB751_RS09015	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HB751_RS09030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HB751_RS09035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB751_RS09040	COG1846	Transcriptional regulator
HB751_RS09060	COG4585	Histidine kinase
HB751_RS09065	COG2197	response regulator
HB751_RS09090	COG3715	PTS system
HB751_RS09095	COG3716	PTS system mannose fructose sorbose family IID component
HB751_RS09105	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HB751_RS09110	COG0459	protein refolding
HB751_RS09120	COG0564	pseudouridine synthase activity
HB751_RS09125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HB751_RS09155	COG0495	leucyl-tRNA aminoacylation
HB751_RS09165	COG1131	(ABC) transporter
HB751_RS09200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB751_RS09205	COG1464	Belongs to the NlpA lipoprotein family
HB751_RS09210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HB751_RS09215	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HB751_RS09225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HB751_RS09235	COG4720	Psort location CytoplasmicMembrane, score
HB751_RS09240	COG1122	ATPase activity
HB751_RS09250	COG0357	Ribosomal RNA small subunit methyltransferase G
HB751_RS09255	COG1704	LemA family
HB751_RS09260	COG0501	Belongs to the peptidase M48B family
HB751_RS09265	COG4591	ABC-type transport system involved in lipoprotein release permease component
HB751_RS09270	COG1136	(ABC) transporter
HB751_RS09285	COG0745	RESPONSE REGULATOR receiver
HB751_RS09290	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HB751_RS09300	COG1484	DNA-dependent DNA replication
HB751_RS09305	COG1160	GTP binding
HB751_RS09315	COG0586	Pfam SNARE associated Golgi protein
HB751_RS09395	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HB751_RS09415	COG2274	protein secretion by the type I secretion system
HB751_RS09420	COG3716	PTS system mannose fructose sorbose family IID component
HB751_RS09425	COG3715	PTS system
HB751_RS09440	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HB751_RS09445	COG0681	Belongs to the peptidase S26 family
HB751_RS09450	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HB751_RS09470	COG1193	negative regulation of DNA recombination
HB751_RS09475	COG3118	belongs to the thioredoxin family
HB751_RS09480	COG1063	alcohol dehydrogenase
HB751_RS09500	COG0360	Binds together with S18 to 16S ribosomal RNA
HB751_RS09505	COG0629	single-stranded DNA binding
HB751_RS09510	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HB751_RS09545	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HB751_RS09550	COG0006	proline dipeptidase activity
HB751_RS09555	COG2131	deaminase
HB751_RS09560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB751_RS09675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HB751_RS09675	COG0551	DNA topoisomerase type I activity
HB751_RS09680	COG0542	response to heat
HB751_RS09790	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HB751_RS09800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HB751_RS09805	COG1609	Transcriptional regulator
HB751_RS09810	COG1621	beta-fructofuranosidase activity
HB751_RS09815	COG2190	(PTS) system
HB751_RS09815	COG1263	PTS System
HB751_RS09815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HB751_RS09820	COG1940	carbohydrate kinase activity
HB751_RS09825	COG1482	cell wall glycoprotein biosynthetic process
HB751_RS09830	COG0653	protein targeting
HB751_RS09835	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HB751_RS09840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HB751_RS09845	COG0736	holo-[acyl-carrier-protein] synthase activity
HB751_RS09850	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HB751_RS09855	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HB751_RS09865	COG0252	asparaginase activity
HB751_RS09870	COG0561	phosphatase activity
HB751_RS09880	COG1268	BioY protein
HB751_RS09885	COG0436	Aminotransferase
HB751_RS09890	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HB751_RS09895	COG1335	isochorismatase
HB751_RS09900	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HB751_RS09905	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HB751_RS09910	COG0154	amidase activity
HB751_RS09915	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HB751_RS09930	COG0745	RESPONSE REGULATOR receiver
HB751_RS10000	COG1819	glycosyl
HB751_RS10005	COG1309	transcriptional regulator
HB751_RS10015	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HB751_RS10020	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HB751_RS10025	COG1534	Rna-binding protein
HB751_RS10030	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HB751_RS10035	COG1713	HD superfamily hydrolase involved in NAD metabolism
HB751_RS10040	COG0799	negative regulation of ribosome biogenesis
HB751_RS10045	COG2226	methyltransferase
HB751_RS10060	COG1323	Belongs to the UPF0348 family
HB751_RS10065	COG1373	ATPase (AAA superfamily
HB751_RS10075	COG0789	Transcriptional regulator
HB751_RS10085	COG1862	Preprotein translocase
HB751_RS10090	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HB751_RS10095	COG4589	Belongs to the CDS family
HB751_RS10105	COG0442	prolyl-tRNA aminoacylation
HB751_RS10165	COG3557	Belongs to the UPF0374 family
HB751_RS10170	COG2137	regulation of response to DNA damage stimulus
HB751_RS10175	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HB751_RS10180	COG1780	Probably involved in ribonucleotide reductase function
HB751_RS10230	COG0525	valine-tRNA ligase activity