locus-tag	class	description
SMUFR_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SMUFR_RS00010	COG0592	DNA-directed DNA polymerase activity
SMUFR_RS00020	COG0012	GTP binding
SMUFR_RS00025	COG0193	aminoacyl-tRNA hydrolase activity
SMUFR_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SMUFR_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SMUFR_RS00055	COG0037	tRNA processing
SMUFR_RS00060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SMUFR_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMUFR_RS00070	COG0531	amino acid
SMUFR_RS00180	COG1792	Involved in formation and maintenance of cell shape
SMUFR_RS00190	COG3942	CHAP domain
SMUFR_RS00195	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMUFR_RS00200	COG0436	Aminotransferase
SMUFR_RS00205	COG1381	Involved in DNA repair and RecF pathway recombination
SMUFR_RS00210	COG0416	fatty acid biosynthetic process
SMUFR_RS00215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMUFR_RS00220	COG2274	protein secretion by the type I secretion system
SMUFR_RS00225	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SMUFR_RS00230	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMUFR_RS00240	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SMUFR_RS00250	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SMUFR_RS00255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SMUFR_RS00265	COG0138	bifunctional purine biosynthesis protein purh
SMUFR_RS00315	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SMUFR_RS00335	COG1794	racemase activity, acting on amino acids and derivatives
SMUFR_RS00355	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMUFR_RS00375	COG2255	four-way junction helicase activity
SMUFR_RS00380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMUFR_RS00400	COG0534	Mate efflux family protein
SMUFR_RS00405	COG3830	Belongs to the UPF0237 family
SMUFR_RS00410	COG2848	UPF0210 protein
SMUFR_RS00425	COG1705	Flagellar rod assembly protein muramidase FlgJ
SMUFR_RS00430	COG1621	beta-fructofuranosidase activity
SMUFR_RS00430	COG3583	domain protein
SMUFR_RS00430	COG5492	domain, Protein
SMUFR_RS00440	COG1420	regulation of RNA biosynthetic process
SMUFR_RS00445	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SMUFR_RS00450	COG0443	Heat shock 70 kDa protein
SMUFR_RS00455	COG0484	heat shock protein binding
SMUFR_RS00460	COG0101	tRNA pseudouridine synthase activity
SMUFR_RS00465	COG0351	phosphomethylpyrimidine kinase
SMUFR_RS00470	COG4720	Psort location CytoplasmicMembrane, score
SMUFR_RS00475	COG4475	Protein of unknown function (DUF436)
SMUFR_RS00480	COG0668	transmembrane transport
SMUFR_RS00490	COG0544	peptidyl-prolyl cis-trans isomerase activity
SMUFR_RS00505	COG3343	RNA polymerase activity
SMUFR_RS00510	COG0504	CTP synthase activity
SMUFR_RS00520	COG0191	fructose-bisphosphate aldolase activity
SMUFR_RS00530	COG3715	PTS system
SMUFR_RS00570	COG1396	sequence-specific DNA binding
SMUFR_RS00580	COG1105	Belongs to the carbohydrate kinase PfkB family
SMUFR_RS00585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUFR_RS00585	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMUFR_RS00585	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMUFR_RS00590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUFR_RS00590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMUFR_RS00590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMUFR_RS00595	COG3684	Belongs to the aldolase LacD family
SMUFR_RS00615	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SMUFR_RS00620	COG0534	Mate efflux family protein
SMUFR_RS00625	COG2176	DNA-directed DNA polymerase activity
SMUFR_RS00630	COG1846	Transcriptional regulator
SMUFR_RS00635	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SMUFR_RS00640	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SMUFR_RS00645	COG0022	dehydrogenase e1 component
SMUFR_RS00645	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMUFR_RS00660	COG0095	Lipoate-protein ligase
SMUFR_RS00665	COG1473	amidohydrolase
SMUFR_RS00670	COG0477	Major facilitator Superfamily
SMUFR_RS00675	COG1309	transcriptional regulator
SMUFR_RS00680	COG0583	DNA-binding transcription factor activity
SMUFR_RS00690	COG0281	malic enzyme
SMUFR_RS00695	COG0679	Auxin Efflux Carrier
SMUFR_RS00700	COG2140	Oxalate decarboxylase
SMUFR_RS00715	COG0242	peptide deformylase activity
SMUFR_RS00720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMUFR_RS00730	COG1012	belongs to the aldehyde dehydrogenase family
SMUFR_RS00730	COG1454	alcohol dehydrogenase
SMUFR_RS00755	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SMUFR_RS00760	COG1185	polyribonucleotide nucleotidyltransferase activity
SMUFR_RS00770	COG1045	serine acetyltransferase
SMUFR_RS00775	COG0215	cysteine-tRNA ligase activity
SMUFR_RS00780	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SMUFR_RS00785	COG5504	Zn-dependent protease
SMUFR_RS00805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMUFR_RS00825	COG1476	TRANSCRIPTIONal
SMUFR_RS00830	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SMUFR_RS00835	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SMUFR_RS00855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMUFR_RS00865	COG0431	NADPH-dependent FMN reductase
SMUFR_RS00865	COG1053	succinate dehydrogenase
SMUFR_RS00865	COG3976	FMN-binding domain protein
SMUFR_RS00870	COG3976	FMN-binding domain protein
SMUFR_RS00870	COG0431	NADPH-dependent FMN reductase
SMUFR_RS00870	COG1053	succinate dehydrogenase
SMUFR_RS00875	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SMUFR_RS00890	COG0803	Belongs to the bacterial solute-binding protein 9 family
SMUFR_RS00900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SMUFR_RS00905	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SMUFR_RS01015	COG1705	Flagellar rod assembly protein muramidase FlgJ
SMUFR_RS01015	COG3942	CHAP domain
SMUFR_RS01025	COG0433	COG0433 Predicted ATPase
SMUFR_RS01065	COG1674	ftsk spoiiie
SMUFR_RS01115	COG1396	sequence-specific DNA binding
SMUFR_RS01130	COG0582	viral genome integration into host DNA
SMUFR_RS01165	COG0028	Belongs to the TPP enzyme family
SMUFR_RS01170	COG0440	acetolactate synthase activity
SMUFR_RS01175	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SMUFR_RS01180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SMUFR_RS01190	COG1309	transcriptional regulator
SMUFR_RS01200	COG1131	(ABC) transporter
SMUFR_RS01210	COG1126	abc transporter atp-binding protein
SMUFR_RS01215	COG0765	amino acid transport
SMUFR_RS01225	COG1968	undecaprenyl-diphosphatase activity
SMUFR_RS01230	COG4862	establishment of competence for transformation
SMUFR_RS01235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMUFR_RS01245	COG0719	Fe-S assembly protein
SMUFR_RS01250	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMUFR_RS01260	COG0719	Fe-S assembly protein
SMUFR_RS01275	COG4166	transmembrane transport
SMUFR_RS01280	COG0601	transmembrane transport
SMUFR_RS01285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMUFR_RS01290	COG0444	Belongs to the ABC transporter superfamily
SMUFR_RS01295	COG4608	Belongs to the ABC transporter superfamily
SMUFR_RS01310	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMUFR_RS01315	COG0531	amino acid
SMUFR_RS01320	COG2957	Belongs to the agmatine deiminase family
SMUFR_RS01330	COG2918	glutathione biosynthetic process
SMUFR_RS01330	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMUFR_RS01335	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SMUFR_RS01350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUFR_RS01400	COG2274	protein secretion by the type I secretion system
SMUFR_RS01420	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SMUFR_RS01450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMUFR_RS01450	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMUFR_RS01455	COG1832	CoA-binding protein
SMUFR_RS01465	COG0343	queuine tRNA-ribosyltransferase activity
SMUFR_RS01480	COG1234	tRNA 3'-trailer cleavage
SMUFR_RS01495	COG0166	Belongs to the GPI family
SMUFR_RS01505	COG3711	transcriptional antiterminator
SMUFR_RS01505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUFR_RS01515	COG3730	PTS system glucitol sorbitol-specific
SMUFR_RS01520	COG3732	PTS system glucitol sorbitol-specific
SMUFR_RS01535	COG2171	N-acyltransferase activity
SMUFR_RS01540	COG1473	amidohydrolase
SMUFR_RS01545	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SMUFR_RS01550	COG0705	Rhomboid family
SMUFR_RS01550	COG0457	Tetratricopeptide repeat
SMUFR_RS01555	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SMUFR_RS01560	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SMUFR_RS01565	COG0756	dUTP diphosphatase activity
SMUFR_RS01590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMUFR_RS01595	COG1827	regulation of RNA biosynthetic process
SMUFR_RS01610	COG0137	argininosuccinate synthase activity
SMUFR_RS01615	COG0165	Argininosuccinate lyase
SMUFR_RS01620	COG0594	ribonuclease P activity
SMUFR_RS01625	COG0706	membrane insertase activity
SMUFR_RS01640	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SMUFR_RS01650	COG0084	hydrolase, TatD family'
SMUFR_RS01685	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SMUFR_RS01705	COG1162	GTPase activity
SMUFR_RS01730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMUFR_RS01735	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SMUFR_RS01740	COG0049	tRNA binding
SMUFR_RS01745	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SMUFR_RS01755	COG0126	phosphoglycerate kinase activity
SMUFR_RS01765	COG0789	Transcriptional regulator
SMUFR_RS01770	COG0174	glutamine synthetase
SMUFR_RS01775	COG0069	glutamate synthase activity
SMUFR_RS01775	COG0067	glutamate synthase
SMUFR_RS01775	COG0070	glutamate synthase
SMUFR_RS01780	COG0493	'glutamate synthase
SMUFR_RS01785	COG3942	CHAP domain
SMUFR_RS01795	COG5503	Protein of unknown function (DUF1447)
SMUFR_RS01815	COG2226	methyltransferase
SMUFR_RS01830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMUFR_RS01845	COG0667	Aldo Keto reductase
SMUFR_RS01850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMUFR_RS01860	COG1214	PFAM Peptidase M22, glycoprotease
SMUFR_RS01865	COG0456	acetyltransferase
SMUFR_RS01870	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SMUFR_RS01890	COG2081	HI0933 family
SMUFR_RS01900	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SMUFR_RS01905	COG2936	dipeptidyl-peptidase activity
SMUFR_RS01920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMUFR_RS01930	COG1882	Formate acetyltransferase
SMUFR_RS01935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMUFR_RS01950	COG0561	phosphatase activity
SMUFR_RS01960	COG2252	PERMEase
SMUFR_RS01965	COG0802	atpase or kinase
SMUFR_RS01970	COG1316	TRANSCRIPTIONal
SMUFR_RS01980	COG0537	adenosine 5'-monophosphoramidase activity
SMUFR_RS01985	COG1131	(ABC) transporter
SMUFR_RS01990	COG4473	ABC transporter
SMUFR_RS02000	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SMUFR_RS02010	COG0779	Required for maturation of 30S ribosomal subunits
SMUFR_RS02015	COG0195	Participates in both transcription termination and antitermination
SMUFR_RS02020	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SMUFR_RS02030	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SMUFR_RS02035	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SMUFR_RS02050	COG2217	Heavy metal translocating P-type atpase
SMUFR_RS02060	COG0561	phosphatase activity
SMUFR_RS02070	COG1131	(ABC) transporter
SMUFR_RS02095	COG2801	Transposase and inactivated derivatives
SMUFR_RS02105	COG1924	4 iron, 4 sulfur cluster binding
SMUFR_RS02125	COG1673	EVE domain
SMUFR_RS02130	COG0752	glycyl-tRNA synthetase alpha subunit
SMUFR_RS02135	COG0751	glycine-tRNA ligase activity
SMUFR_RS02140	COG4224	UPF0291 protein
SMUFR_RS02150	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SMUFR_RS02155	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SMUFR_RS02160	COG0275	rRNA processing
SMUFR_RS02165	COG4839	cell division protein FtsL
SMUFR_RS02170	COG0768	penicillin binding
SMUFR_RS02175	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMUFR_RS02185	COG0513	Belongs to the DEAD box helicase family
SMUFR_RS02200	COG1126	abc transporter atp-binding protein
SMUFR_RS02210	COG0492	ferredoxin-NADP+ reductase activity
SMUFR_RS02215	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SMUFR_RS02220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMUFR_RS02225	COG3579	cysteine-type endopeptidase activity
SMUFR_RS02230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMUFR_RS02235	COG3331	DNA recombination
SMUFR_RS02240	COG4474	Belongs to the UPF0398 family
SMUFR_RS02245	COG3599	regulation of cell shape
SMUFR_RS02250	COG0116	Belongs to the methyltransferase superfamily
SMUFR_RS02260	COG1854	S-ribosylhomocysteine lyase activity
SMUFR_RS02265	COG1418	mRNA catabolic process
SMUFR_RS02265	COG4372	Transposase
SMUFR_RS02270	COG0194	GDP metabolic process
SMUFR_RS02280	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SMUFR_RS02285	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SMUFR_RS02290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SMUFR_RS02290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMUFR_RS02310	COG4585	Histidine kinase
SMUFR_RS02315	COG2197	response regulator
SMUFR_RS02325	COG1098	S1 RNA binding domain
SMUFR_RS02330	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SMUFR_RS02335	COG1349	DNA-binding transcription factor activity
SMUFR_RS02340	COG1882	Formate acetyltransferase
SMUFR_RS02360	COG1739	Uncharacterized protein family UPF0029
SMUFR_RS02365	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SMUFR_RS02370	COG1040	competence protein
SMUFR_RS02415	COG1349	DNA-binding transcription factor activity
SMUFR_RS02420	COG0561	phosphatase activity
SMUFR_RS02455	COG4716	Myosin-crossreactive antigen
SMUFR_RS02460	COG0742	ribosomal rna small subunit methyltransferase
SMUFR_RS02465	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SMUFR_RS02470	COG3480	Lon protease (S16) C-terminal proteolytic domain
SMUFR_RS02475	COG0737	Belongs to the 5'-nucleotidase family
SMUFR_RS02480	COG4470	Protein conserved in bacteria
SMUFR_RS02485	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SMUFR_RS02495	COG1132	(ABC) transporter
SMUFR_RS02500	COG1132	(ABC) transporter
SMUFR_RS02510	COG3804	dihydrodipicolinate reductase
SMUFR_RS02530	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SMUFR_RS02535	COG0512	Glutamine amidotransferase of anthranilate synthase
SMUFR_RS02540	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SMUFR_RS02545	COG0134	indole-3-glycerol-phosphate synthase activity
SMUFR_RS02550	COG0135	phosphoribosylanthranilate isomerase activity
SMUFR_RS02555	COG0133	tryptophan synthase activity
SMUFR_RS02560	COG0159	tryptophan synthase activity
SMUFR_RS02570	COG0783	Belongs to the Dps family
SMUFR_RS02580	COG1940	carbohydrate kinase activity
SMUFR_RS02585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SMUFR_RS02590	COG1217	gtp-binding protein TYPA
SMUFR_RS02600	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SMUFR_RS02605	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SMUFR_RS02625	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SMUFR_RS02630	COG1799	cell septum assembly
SMUFR_RS02640	COG2302	S4 RNA-binding domain
SMUFR_RS02645	COG3599	regulation of cell shape
SMUFR_RS02650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SMUFR_RS02670	COG0542	response to heat
SMUFR_RS02675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMUFR_RS02680	COG4703	Protein of unknown function (DUF1797)
SMUFR_RS02685	COG2801	Transposase and inactivated derivatives
SMUFR_RS02695	COG0765	amino acid transport
SMUFR_RS02700	COG1126	abc transporter atp-binding protein
SMUFR_RS02720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SMUFR_RS02725	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SMUFR_RS02730	COG1346	cytolysis
SMUFR_RS02735	COG1380	Effector of murein hydrolase LrgA
SMUFR_RS02740	COG3279	Response regulator of the LytR AlgR family
SMUFR_RS02745	COG3275	phosphorelay sensor kinase activity
SMUFR_RS02750	COG1570	exodeoxyribonuclease VII activity
SMUFR_RS02755	COG1722	exodeoxyribonuclease VII activity
SMUFR_RS02765	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SMUFR_RS02770	COG1438	arginine binding
SMUFR_RS02775	COG0497	DNA recombination
SMUFR_RS02780	COG1307	EDD domain protein, DegV family
SMUFR_RS02785	COG2755	lipolytic protein G-D-S-L family
SMUFR_RS02795	COG0776	regulation of translation
SMUFR_RS02810	COG0735	belongs to the Fur family
SMUFR_RS02825	COG0588	phosphoglycerate mutase activity
SMUFR_RS02830	COG0768	penicillin binding
SMUFR_RS02835	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SMUFR_RS02840	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMUFR_RS02850	COG0385	Bile acid
SMUFR_RS02855	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SMUFR_RS02875	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SMUFR_RS02885	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SMUFR_RS02885	COG3064	Membrane
SMUFR_RS02890	COG0513	Belongs to the DEAD box helicase family
SMUFR_RS02915	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SMUFR_RS02925	COG0726	polysaccharide deacetylase
SMUFR_RS02930	COG0204	Acyl-transferase
SMUFR_RS02935	COG1596	polysaccharide export
SMUFR_RS02935	COG1555	photosystem II stabilization
SMUFR_RS02940	COG0658	competence protein
SMUFR_RS02940	COG2333	competence protein COMEC
SMUFR_RS02955	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SMUFR_RS02980	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SMUFR_RS02990	COG0363	glucosamine-6-phosphate deaminase activity
SMUFR_RS03000	COG1187	pseudouridine synthase activity
SMUFR_RS03010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMUFR_RS03015	COG1028	Short-chain dehydrogenase reductase Sdr
SMUFR_RS03015	COG0604	alcohol dehydrogenase
SMUFR_RS03015	COG3321	synthase
SMUFR_RS03040	COG0131	Imidazoleglycerol-phosphate dehydratase
SMUFR_RS03040	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SMUFR_RS03045	COG4122	O-methyltransferase activity
SMUFR_RS03050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMUFR_RS03060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMUFR_RS03080	COG1131	(ABC) transporter
SMUFR_RS03125	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SMUFR_RS03130	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SMUFR_RS03135	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SMUFR_RS03140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMUFR_RS03150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMUFR_RS03155	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SMUFR_RS03160	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SMUFR_RS03165	COG0372	Belongs to the citrate synthase family
SMUFR_RS03170	COG0538	isocitrate dehydrogenase activity
SMUFR_RS03185	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUFR_RS03190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMUFR_RS03195	COG1012	belongs to the aldehyde dehydrogenase family
SMUFR_RS03200	COG0789	Transcriptional regulator
SMUFR_RS03205	COG0656	L-ascorbic acid biosynthetic process
SMUFR_RS03210	COG0656	L-ascorbic acid biosynthetic process
SMUFR_RS03225	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SMUFR_RS03260	COG2195	Cleaves the N-terminal amino acid of tripeptides
SMUFR_RS03280	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SMUFR_RS03285	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SMUFR_RS03290	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SMUFR_RS03295	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SMUFR_RS03300	COG0588	phosphoglycerate mutase activity
SMUFR_RS03310	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SMUFR_RS03325	COG3859	Proton-coupled thiamine transporter YuaJ
SMUFR_RS03345	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SMUFR_RS03350	COG0772	Belongs to the SEDS family
SMUFR_RS03355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMUFR_RS03360	COG0149	triose-phosphate isomerase activity
SMUFR_RS03380	COG1078	dGTPase activity
SMUFR_RS03400	COG0584	glycerophosphoryl diester phosphodiesterase
SMUFR_RS03415	COG0604	alcohol dehydrogenase
SMUFR_RS03470	COG0561	phosphatase activity
SMUFR_RS03475	COG0561	phosphatase activity
SMUFR_RS03480	COG0552	protein localization to endoplasmic reticulum
SMUFR_RS03485	COG0477	Major facilitator Superfamily
SMUFR_RS03490	COG3689	TIGRFAM TIGR03943 family protein
SMUFR_RS03495	COG0701	Predicted permease
SMUFR_RS03505	COG2183	response to ionizing radiation
SMUFR_RS03510	COG3091	SprT-like family
SMUFR_RS03520	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SMUFR_RS03525	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SMUFR_RS03550	COG0826	peptidase U32
SMUFR_RS03555	COG0450	alkyl hydroperoxide reductase
SMUFR_RS03570	COG2801	Transposase and inactivated derivatives
SMUFR_RS03580	COG4443	Transcriptional Coactivator p15 (PC4)
SMUFR_RS03585	COG1914	H( )-stimulated, divalent metal cation uptake system
SMUFR_RS03595	COG0366	Alpha amylase catalytic
SMUFR_RS03595	COG5263	repeat protein
SMUFR_RS03600	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SMUFR_RS03610	COG1368	sulfuric ester hydrolase activity
SMUFR_RS03615	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SMUFR_RS03620	COG0710	3-dehydroquinate dehydratase activity
SMUFR_RS03625	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SMUFR_RS03630	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SMUFR_RS03635	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SMUFR_RS03640	COG0287	Prephenate dehydrogenase
SMUFR_RS03645	COG3679	Belongs to the UPF0342 family
SMUFR_RS03650	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SMUFR_RS03655	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SMUFR_RS03660	COG0077	Prephenate dehydratase
SMUFR_RS03670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMUFR_RS03680	COG3620	sequence-specific DNA binding
SMUFR_RS03720	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SMUFR_RS03730	COG0488	(ABC) transporter
SMUFR_RS03740	COG1126	abc transporter atp-binding protein
SMUFR_RS03755	COG0556	nucleotide-excision repair
SMUFR_RS03770	COG1051	belongs to the nudix hydrolase family
SMUFR_RS03775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUFR_RS03785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUFR_RS03795	COG1970	mechanosensitive ion channel activity
SMUFR_RS03805	COG0358	DNA primase activity
SMUFR_RS03810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMUFR_RS03815	COG2151	metal-sulfur cluster biosynthetic enzyme
SMUFR_RS03820	COG1091	dTDP-4-dehydrorhamnose reductase activity
SMUFR_RS03855	COG1368	sulfuric ester hydrolase activity
SMUFR_RS03865	COG0463	Glycosyl transferase, family 2
SMUFR_RS03880	COG3942	CHAP domain
SMUFR_RS03885	COG0656	L-ascorbic acid biosynthetic process
SMUFR_RS03890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMUFR_RS03895	COG0285	dihydrofolate synthase activity
SMUFR_RS03905	COG1104	cysteine desulfurase activity
SMUFR_RS03910	COG0301	tRNA thio-modification
SMUFR_RS03930	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SMUFR_RS03940	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SMUFR_RS03950	COG2816	NAD+ diphosphatase activity
SMUFR_RS03955	COG0583	DNA-binding transcription factor activity
SMUFR_RS03960	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SMUFR_RS03965	COG0564	pseudouridine synthase activity
SMUFR_RS03975	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SMUFR_RS03985	COG0540	Belongs to the ATCase OTCase family
SMUFR_RS03990	COG0505	Belongs to the CarA family
SMUFR_RS03995	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SMUFR_RS04005	COG1136	(ABC) transporter
SMUFR_RS04010	COG0577	efflux transmembrane transporter activity
SMUFR_RS04015	COG0228	four-way junction DNA binding
SMUFR_RS04020	COG1837	Belongs to the UPF0109 family
SMUFR_RS04025	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SMUFR_RS04030	COG0336	Belongs to the RNA methyltransferase TrmD family
SMUFR_RS04035	COG0492	ferredoxin-NADP+ reductase activity
SMUFR_RS04040	COG1349	DNA-binding transcription factor activity
SMUFR_RS04045	COG1105	Belongs to the carbohydrate kinase PfkB family
SMUFR_RS04050	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMUFR_RS04050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUFR_RS04050	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMUFR_RS04055	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SMUFR_RS04060	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SMUFR_RS04060	COG0646	methionine synthase
SMUFR_RS04075	COG2207	Transcriptional regulator
SMUFR_RS04080	COG3345	alpha-galactosidase
SMUFR_RS04085	COG1653	transport
SMUFR_RS04090	COG1175	transmembrane transport
SMUFR_RS04095	COG0395	ABC-type sugar transport system, permease component
SMUFR_RS04100	COG0366	Alpha amylase catalytic
SMUFR_RS04105	COG3842	ATPase activity
SMUFR_RS04110	COG0366	Alpha amylase catalytic
SMUFR_RS04115	COG1609	Transcriptional regulator
SMUFR_RS04120	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SMUFR_RS04125	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SMUFR_RS04130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SMUFR_RS04180	COG1307	EDD domain protein, DegV family
SMUFR_RS04185	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SMUFR_RS04190	COG0617	tRNA 3'-terminal CCA addition
SMUFR_RS04195	COG0488	(ABC) transporter
SMUFR_RS04210	COG1132	(ABC) transporter
SMUFR_RS04220	COG5263	repeat protein
SMUFR_RS04220	COG0366	Alpha amylase catalytic
SMUFR_RS04230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SMUFR_RS04240	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SMUFR_RS04245	COG0602	queuosine metabolic process
SMUFR_RS04255	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SMUFR_RS04270	COG1132	(ABC) transporter
SMUFR_RS04275	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SMUFR_RS04285	COG2357	RelA SpoT domain protein
SMUFR_RS04290	COG0745	RESPONSE REGULATOR receiver
SMUFR_RS04300	COG3759	membrane
SMUFR_RS04305	COG0583	DNA-binding transcription factor activity
SMUFR_RS04315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUFR_RS04320	COG0765	amino acid transport
SMUFR_RS04325	COG0765	amino acid transport
SMUFR_RS04330	COG1126	abc transporter atp-binding protein
SMUFR_RS04345	COG1304	FMN binding
SMUFR_RS04350	COG1272	protein, Hemolysin III
SMUFR_RS04365	COG3425	synthase
SMUFR_RS04370	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SMUFR_RS04375	COG3201	nicotinamide mononucleotide transporter
SMUFR_RS04380	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SMUFR_RS04390	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SMUFR_RS04395	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SMUFR_RS04400	COG0833	amino acid
SMUFR_RS04405	COG2040	homocysteine
SMUFR_RS04410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMUFR_RS04430	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SMUFR_RS04435	COG0222	ribosome binding
SMUFR_RS04445	COG1960	acyl-CoA dehydrogenase activity
SMUFR_RS04450	COG0726	polysaccharide deacetylase
SMUFR_RS04460	COG0083	homoserine kinase activity
SMUFR_RS04465	COG0285	dihydrofolate synthase activity
SMUFR_RS04470	COG0302	gtp cyclohydrolase
SMUFR_RS04490	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SMUFR_RS04495	COG3842	ATPase activity
SMUFR_RS04500	COG1176	ABC-type spermidine putrescine transport system, permease component I
SMUFR_RS04505	COG1177	transmembrane transport
SMUFR_RS04510	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SMUFR_RS04520	COG1263	PTS System
SMUFR_RS04520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMUFR_RS04520	COG2190	(PTS) system
SMUFR_RS04550	COG4932	domain protein
SMUFR_RS04555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SMUFR_RS04565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SMUFR_RS04570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMUFR_RS04585	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SMUFR_RS04590	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SMUFR_RS04595	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMUFR_RS04600	COG4605	iron ion homeostasis
SMUFR_RS04605	COG4604	ABC transporter, ATP-binding protein
SMUFR_RS04610	COG4607	ABC-type enterochelin transport system periplasmic component
SMUFR_RS04625	COG0758	DNA mediated transformation
SMUFR_RS04630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMUFR_RS04635	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SMUFR_RS04640	COG5263	repeat protein
SMUFR_RS04640	COG0366	Alpha amylase catalytic
SMUFR_RS04645	COG5263	repeat protein
SMUFR_RS04645	COG0366	Alpha amylase catalytic
SMUFR_RS04650	COG1136	(ABC) transporter
SMUFR_RS04660	COG0745	RESPONSE REGULATOR receiver
SMUFR_RS04665	COG0642	Histidine kinase
SMUFR_RS04670	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SMUFR_RS04675	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
SMUFR_RS04685	COG2851	Citrate transporter
SMUFR_RS04695	COG0511	ligase activity, forming carbon-carbon bonds
SMUFR_RS04700	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SMUFR_RS04710	COG3052	prosthetic group binding
SMUFR_RS04780	COG4974	Belongs to the 'phage' integrase family
SMUFR_RS04785	COG1131	(ABC) transporter
SMUFR_RS04795	COG5002	protein histidine kinase activity
SMUFR_RS04800	COG0745	RESPONSE REGULATOR receiver
SMUFR_RS04805	COG1442	glycosyl transferase family 8
SMUFR_RS04810	COG4221	oxidoreductase activity
SMUFR_RS04815	COG1131	(ABC) transporter
SMUFR_RS04825	COG0280	phosphate acetyltransferase
SMUFR_RS04830	COG0564	pseudouridine synthase activity
SMUFR_RS04835	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SMUFR_RS04840	COG2357	RelA SpoT domain protein
SMUFR_RS04850	COG4116	CYTH
SMUFR_RS04855	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMUFR_RS04860	COG1104	cysteine desulfurase activity
SMUFR_RS04870	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SMUFR_RS04875	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SMUFR_RS04900	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SMUFR_RS04905	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SMUFR_RS04915	COG4175	Glycine betaine
SMUFR_RS04915	COG3448	diguanylate cyclase activity
SMUFR_RS04925	COG2188	Transcriptional regulator
SMUFR_RS04930	COG0519	Catalyzes the synthesis of GMP from XMP
SMUFR_RS04940	COG1131	(ABC) transporter
SMUFR_RS04960	COG1247	-acetyltransferase
SMUFR_RS04965	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SMUFR_RS04975	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SMUFR_RS04980	COG4684	Psort location CytoplasmicMembrane, score
SMUFR_RS04985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMUFR_RS04990	COG1132	(ABC) transporter
SMUFR_RS04995	COG1132	(ABC) transporter
SMUFR_RS05010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMUFR_RS05015	COG0009	L-threonylcarbamoyladenylate synthase
SMUFR_RS05020	COG2890	protein-(glutamine-N5) methyltransferase activity
SMUFR_RS05025	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SMUFR_RS05030	COG1435	thymidine kinase activity
SMUFR_RS05035	COG1942	4-Oxalocrotonate Tautomerase
SMUFR_RS05050	COG0431	NADPH-dependent FMN reductase
SMUFR_RS05050	COG1053	succinate dehydrogenase
SMUFR_RS05050	COG3976	FMN-binding domain protein
SMUFR_RS05065	COG0577	efflux transmembrane transporter activity
SMUFR_RS05070	COG1136	(ABC) transporter
SMUFR_RS05075	COG1174	glycine betaine transport
SMUFR_RS05090	COG1063	alcohol dehydrogenase
SMUFR_RS05095	COG0628	permease
SMUFR_RS05100	COG2723	6-phospho-beta-galactosidase activity
SMUFR_RS05105	COG0588	phosphoglycerate mutase activity
SMUFR_RS05110	COG0406	alpha-ribazole phosphatase activity
SMUFR_RS05125	COG0561	phosphatase activity
SMUFR_RS05140	COG0346	lactoylglutathione lyase activity
SMUFR_RS05145	COG3764	Sortase (surface protein transpeptidase)
SMUFR_RS05155	COG0039	L-malate dehydrogenase activity
SMUFR_RS05170	COG1079	Belongs to the binding-protein-dependent transport system permease family
SMUFR_RS05175	COG4603	Belongs to the binding-protein-dependent transport system permease family
SMUFR_RS05180	COG3845	ABC transporter
SMUFR_RS05185	COG1744	ABC transporter substrate-binding protein PnrA-like
SMUFR_RS05190	COG0295	cytidine deaminase activity
SMUFR_RS05195	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SMUFR_RS05200	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SMUFR_RS05205	COG2813	Specifically methylates the guanine in position
SMUFR_RS05210	COG1072	(Pantothenic acid kinase))
SMUFR_RS05215	COG0268	Binds directly to 16S ribosomal RNA
SMUFR_RS05220	COG5002	protein histidine kinase activity
SMUFR_RS05225	COG0745	RESPONSE REGULATOR receiver
SMUFR_RS05240	COG0704	Plays a role in the regulation of phosphate uptake
SMUFR_RS05245	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SMUFR_RS05250	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SMUFR_RS05255	COG0581	inorganic phosphate transmembrane transporter activity
SMUFR_RS05260	COG0573	inorganic phosphate transmembrane transporter activity
SMUFR_RS05270	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SMUFR_RS05270	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SMUFR_RS05275	COG0483	inositol monophosphate 1-phosphatase activity
SMUFR_RS05280	COG4476	Belongs to the UPF0223 family
SMUFR_RS05285	COG1393	Belongs to the ArsC family
SMUFR_RS05290	COG0196	riboflavin kinase activity
SMUFR_RS05295	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SMUFR_RS05300	COG2205	protein histidine kinase activity
SMUFR_RS05305	COG0745	RESPONSE REGULATOR receiver
SMUFR_RS05370	COG1132	(ABC) transporter
SMUFR_RS05375	COG2375	cellular response to nickel ion
SMUFR_RS05375	COG1132	(ABC) transporter
SMUFR_RS05400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMUFR_RS05405	COG0785	Cytochrome C biogenesis protein
SMUFR_RS05420	COG2873	o-acetylhomoserine
SMUFR_RS05425	COG0210	DNA helicase
SMUFR_RS05430	COG1115	amino acid carrier protein
SMUFR_RS05435	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SMUFR_RS05440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUFR_RS05445	COG1126	abc transporter atp-binding protein
SMUFR_RS05450	COG0765	amino acid transport
SMUFR_RS05455	COG2824	Alkylphosphonate utilization operon protein PhnA
SMUFR_RS05460	COG0246	Mannitol dehydrogenase
SMUFR_RS05465	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUFR_RS05470	COG3711	transcriptional antiterminator
SMUFR_RS05475	COG2213	PTS system mannitol-specific
SMUFR_RS05480	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMUFR_RS05490	COG2261	transglycosylase associated protein
SMUFR_RS05495	COG0469	pyruvate kinase activity
SMUFR_RS05500	COG0205	6-phosphofructokinase activity
SMUFR_RS05510	COG1725	Transcriptional regulator
SMUFR_RS05515	COG1131	(ABC) transporter
SMUFR_RS05540	COG0539	negative regulation of cytoplasmic translation
SMUFR_RS05560	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SMUFR_RS05580	COG2184	nucleotidyltransferase activity
SMUFR_RS05595	COG0187	DNA topoisomerase II activity
SMUFR_RS05600	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SMUFR_RS05605	COG0737	Belongs to the 5'-nucleotidase family
SMUFR_RS05615	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SMUFR_RS05620	COG0765	amino acid transport
SMUFR_RS05625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUFR_RS05635	COG2315	Protein conserved in bacteria
SMUFR_RS05640	COG1881	PFAM PEBP family protein
SMUFR_RS05650	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SMUFR_RS05655	COG0284	orotidine-5'-phosphate decarboxylase activity
SMUFR_RS05660	COG0167	dihydroorotate dehydrogenase activity
SMUFR_RS05665	COG0543	2 iron, 2 sulfur cluster binding
SMUFR_RS05680	COG0813	purine-nucleoside phosphorylase activity
SMUFR_RS05705	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SMUFR_RS05710	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SMUFR_RS05715	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SMUFR_RS05735	COG1573	uracil-dna glycosylase
SMUFR_RS05740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMUFR_RS05750	COG0322	excinuclease ABC activity
SMUFR_RS05765	COG1011	Hydrolase
SMUFR_RS05775	COG0148	phosphopyruvate hydratase activity
SMUFR_RS05845	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SMUFR_RS05850	COG0107	imidazoleglycerol-phosphate synthase activity
SMUFR_RS05855	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SMUFR_RS05860	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SMUFR_RS05870	COG0131	Imidazoleglycerol-phosphate dehydratase
SMUFR_RS05875	COG0560	Phosphoserine phosphatase
SMUFR_RS05880	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SMUFR_RS05885	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SMUFR_RS05890	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SMUFR_RS05895	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMUFR_RS05905	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SMUFR_RS05920	COG0772	Belongs to the SEDS family
SMUFR_RS05945	COG2814	Major facilitator Superfamily
SMUFR_RS05955	COG0335	large ribosomal subunit rRNA binding
SMUFR_RS05960	COG0038	chloride channel
SMUFR_RS05965	COG0038	chloride channel
SMUFR_RS05970	COG0077	Prephenate dehydratase
SMUFR_RS05970	COG1605	Chorismate mutase
SMUFR_RS05985	COG0716	FMN binding
SMUFR_RS05990	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMUFR_RS05995	COG0625	glutathione transferase activity
SMUFR_RS06000	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SMUFR_RS06005	COG0254	rRNA binding
SMUFR_RS06020	COG2226	methyltransferase
SMUFR_RS06035	COG1481	regulation of sporulation
SMUFR_RS06045	COG1660	Displays ATPase and GTPase activities
SMUFR_RS06055	COG0251	oxidation-reduction process
SMUFR_RS06060	COG0371	Dehydrogenase
SMUFR_RS06065	COG0017	Asparaginyl-tRNA synthetase
SMUFR_RS06070	COG0436	Aminotransferase
SMUFR_RS06075	COG1199	ATP-dependent helicase activity
SMUFR_RS06075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SMUFR_RS06085	COG1122	ATPase activity
SMUFR_RS06125	COG2177	Part of the ABC transporter FtsEX involved in
SMUFR_RS06130	COG2884	Cell division ATP-binding protein ftsE
SMUFR_RS06140	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SMUFR_RS06225	COG1136	(ABC) transporter
SMUFR_RS06255	COG1309	transcriptional regulator
SMUFR_RS06270	COG1136	(ABC) transporter
SMUFR_RS06275	COG2226	methyltransferase
SMUFR_RS06280	COG2801	Transposase and inactivated derivatives
SMUFR_RS06310	COG0456	acetyltransferase
SMUFR_RS06310	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SMUFR_RS06330	COG2801	Transposase and inactivated derivatives
SMUFR_RS06335	COG0066	3-isopropylmalate dehydratase activity
SMUFR_RS06340	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SMUFR_RS06345	COG0473	3-isopropylmalate dehydrogenase activity
SMUFR_RS06355	COG0572	uridine kinase
SMUFR_RS06360	COG0673	inositol 2-dehydrogenase activity
SMUFR_RS06370	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SMUFR_RS06395	COG0481	GTPase activity
SMUFR_RS06420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SMUFR_RS06440	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SMUFR_RS06445	COG1518	maintenance of DNA repeat elements
SMUFR_RS06450	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
SMUFR_RS06460	COG2801	Transposase and inactivated derivatives
SMUFR_RS06475	COG1053	succinate dehydrogenase
SMUFR_RS06475	COG3976	FMN-binding domain protein
SMUFR_RS06485	COG0577	efflux transmembrane transporter activity
SMUFR_RS06485	COG1136	(ABC) transporter
SMUFR_RS06495	COG0647	UMP catabolic process
SMUFR_RS06500	COG1051	belongs to the nudix hydrolase family
SMUFR_RS06510	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMUFR_RS06520	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMUFR_RS06525	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMUFR_RS06530	COG0022	dehydrogenase e1 component
SMUFR_RS06535	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SMUFR_RS06545	COG0542	response to heat
SMUFR_RS06550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMUFR_RS06560	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SMUFR_RS06565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SMUFR_RS06570	COG3442	glutamine amidotransferase
SMUFR_RS06575	COG0488	(ABC) transporter
SMUFR_RS06585	COG1215	transferase activity, transferring glycosyl groups
SMUFR_RS06600	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SMUFR_RS06610	COG4808	Protein conserved in bacteria
SMUFR_RS06630	COG3842	ATPase activity
SMUFR_RS06645	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SMUFR_RS06650	COG1113	amino acid transport
SMUFR_RS06655	COG3527	Alpha-acetolactate decarboxylase
SMUFR_RS06660	COG0028	Belongs to the TPP enzyme family
SMUFR_RS06670	COG0628	permease
SMUFR_RS06675	COG1051	belongs to the nudix hydrolase family
SMUFR_RS06685	COG1088	dTDP-glucose 4,6-dehydratase activity
SMUFR_RS06695	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SMUFR_RS06700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMUFR_RS06710	COG2384	SAM-dependent methyltransferase
SMUFR_RS06720	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SMUFR_RS06725	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMUFR_RS06745	COG2378	regulation of single-species biofilm formation
SMUFR_RS06750	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SMUFR_RS06750	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SMUFR_RS06755	COG0300	oxidoreductase activity
SMUFR_RS06760	COG1234	tRNA 3'-trailer cleavage
SMUFR_RS06770	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SMUFR_RS06775	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SMUFR_RS06805	COG1401	restriction endodeoxyribonuclease activity
SMUFR_RS06830	COG2723	6-phospho-beta-galactosidase activity
SMUFR_RS06835	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMUFR_RS06835	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMUFR_RS06840	COG1447	Phosphotransferase system cellobiose-specific component IIA
SMUFR_RS06845	COG3684	Belongs to the aldolase LacD family
SMUFR_RS06850	COG1105	Belongs to the carbohydrate kinase PfkB family
SMUFR_RS06855	COG0698	ribose 5-phosphate isomerase
SMUFR_RS06860	COG0698	ribose 5-phosphate isomerase
SMUFR_RS06865	COG1349	DNA-binding transcription factor activity
SMUFR_RS06870	COG1074	ATP-dependent DNA helicase activity
SMUFR_RS06875	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SMUFR_RS06900	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SMUFR_RS06905	COG1396	sequence-specific DNA binding
SMUFR_RS06910	COG0072	phenylalanine-tRNA ligase activity
SMUFR_RS06910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMUFR_RS06920	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SMUFR_RS06925	COG1196	nuclear chromosome segregation
SMUFR_RS06930	COG0571	ribonuclease III activity
SMUFR_RS06935	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SMUFR_RS06940	COG5002	protein histidine kinase activity
SMUFR_RS06945	COG0745	RESPONSE REGULATOR receiver
SMUFR_RS06950	COG1126	abc transporter atp-binding protein
SMUFR_RS06955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUFR_RS06960	COG0765	amino acid transport
SMUFR_RS06965	COG0765	amino acid transport
SMUFR_RS06980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMUFR_RS06990	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SMUFR_RS06995	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SMUFR_RS07000	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SMUFR_RS07005	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SMUFR_RS07010	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMUFR_RS07015	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SMUFR_RS07020	COG0356	it plays a direct role in the translocation of protons across the membrane
SMUFR_RS07030	COG0058	SHG alpha-glucan phosphorylase activity
SMUFR_RS07035	COG0297	glycogen (starch) synthase activity
SMUFR_RS07040	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SMUFR_RS07045	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SMUFR_RS07050	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SMUFR_RS07060	COG1523	belongs to the glycosyl hydrolase 13 family
SMUFR_RS07065	COG1597	lipid kinase activity
SMUFR_RS07070	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMUFR_RS07075	COG4708	membrane
SMUFR_RS07085	COG2197	response regulator
SMUFR_RS07090	COG4585	Histidine kinase
SMUFR_RS07100	COG1131	(ABC) transporter
SMUFR_RS07120	COG1295	ribonuclease BN
SMUFR_RS07130	COG4109	DRTGG domain
SMUFR_RS07150	COG0569	domain protein
SMUFR_RS07155	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SMUFR_RS07160	COG0058	SHG alpha-glucan phosphorylase activity
SMUFR_RS07165	COG1640	4-alpha-glucanotransferase
SMUFR_RS07170	COG1609	Transcriptional regulator
SMUFR_RS07180	COG1175	transmembrane transport
SMUFR_RS07185	COG3833	ABC-type maltose transport systems, permease component
SMUFR_RS07190	COG3842	ATPase activity
SMUFR_RS07195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMUFR_RS07200	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SMUFR_RS07220	COG5290	Psort location Cytoplasmic, score
SMUFR_RS07235	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SMUFR_RS07240	COG1956	GAF domain-containing protein
SMUFR_RS07245	COG4716	Myosin-crossreactive antigen
SMUFR_RS07255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMUFR_RS07265	COG0438	transferase activity, transferring glycosyl groups
SMUFR_RS07280	COG1609	Transcriptional regulator
SMUFR_RS07300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMUFR_RS07310	COG1447	Phosphotransferase system cellobiose-specific component IIA
SMUFR_RS07315	COG3711	transcriptional antiterminator
SMUFR_RS07315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUFR_RS07320	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMUFR_RS07325	COG2723	6-phospho-beta-galactosidase activity
SMUFR_RS07330	COG0778	Nitroreductase
SMUFR_RS07335	COG0346	lactoylglutathione lyase activity
SMUFR_RS07345	COG2814	Major facilitator Superfamily
SMUFR_RS07350	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SMUFR_RS07355	COG0557	exoribonuclease II activity
SMUFR_RS07365	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMUFR_RS07370	COG2814	Major facilitator Superfamily
SMUFR_RS07375	COG2264	protein methyltransferase activity
SMUFR_RS07380	COG0237	dephospho-CoA kinase activity
SMUFR_RS07385	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SMUFR_RS07400	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SMUFR_RS07405	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SMUFR_RS07410	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SMUFR_RS07415	COG1702	phosphate starvation-inducible protein PhoH
SMUFR_RS07420	COG4479	Belongs to the UPF0346 family
SMUFR_RS07425	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMUFR_RS07435	COG0233	cytoplasmic translational termination
SMUFR_RS07440	COG0528	UMP kinase activity
SMUFR_RS07445	COG0081	regulation of translation
SMUFR_RS07450	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SMUFR_RS07460	COG1674	ftsk spoiiie
SMUFR_RS07485	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SMUFR_RS07500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMUFR_RS07500	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMUFR_RS07535	COG0640	Transcriptional regulator
SMUFR_RS07545	COG0708	Exodeoxyribonuclease III
SMUFR_RS07550	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SMUFR_RS07555	COG1393	Belongs to the ArsC family
SMUFR_RS07560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMUFR_RS07565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMUFR_RS07570	COG0454	-acetyltransferase
SMUFR_RS07580	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SMUFR_RS07585	COG0347	Belongs to the P(II) protein family
SMUFR_RS07590	COG0004	ammonium transporteR
SMUFR_RS07600	COG4467	Involved in initiation control of chromosome replication
SMUFR_RS07605	COG1774	PSP1 C-terminal conserved region
SMUFR_RS07610	COG0470	DNA polymerase III
SMUFR_RS07615	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SMUFR_RS07620	COG0517	IMP dehydrogenase activity
SMUFR_RS07640	COG0559	Belongs to the binding-protein-dependent transport system permease family
SMUFR_RS07650	COG4471	UPF0298 protein
SMUFR_RS07660	COG0740	serine-type endopeptidase activity
SMUFR_RS07665	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SMUFR_RS07670	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SMUFR_RS07675	COG0626	cystathionine gamma-synthase activity
SMUFR_RS07680	COG2244	polysaccharide biosynthetic process
SMUFR_RS07685	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SMUFR_RS07710	COG0693	protein deglycase activity
SMUFR_RS07715	COG2378	regulation of single-species biofilm formation
SMUFR_RS07725	COG1227	inorganic diphosphatase activity
SMUFR_RS07730	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SMUFR_RS07735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMUFR_RS07740	COG1696	Membrane protein involved in D-alanine export
SMUFR_RS07745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMUFR_RS07750	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SMUFR_RS07755	COG1253	flavin adenine dinucleotide binding
SMUFR_RS07760	COG0628	permease
SMUFR_RS07765	COG1119	ATPase activity
SMUFR_RS07770	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SMUFR_RS07775	COG1242	4 iron, 4 sulfur cluster binding
SMUFR_RS07780	COG1346	cytolysis
SMUFR_RS07790	COG0671	phosphoesterase, PA-phosphatase related
SMUFR_RS07795	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SMUFR_RS07820	COG0569	domain protein
SMUFR_RS07825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SMUFR_RS07830	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SMUFR_RS07835	COG1187	pseudouridine synthase activity
SMUFR_RS07840	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SMUFR_RS07845	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SMUFR_RS07850	COG0582	viral genome integration into host DNA
SMUFR_RS07865	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SMUFR_RS07870	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SMUFR_RS07875	COG3763	UPF0154 protein
SMUFR_RS07880	COG0019	diaminopimelate decarboxylase activity
SMUFR_RS07895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMUFR_RS07900	COG1254	Belongs to the acylphosphatase family
SMUFR_RS07905	COG0706	membrane insertase activity
SMUFR_RS07910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMUFR_RS07915	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SMUFR_RS07925	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SMUFR_RS07935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SMUFR_RS07950	COG0439	Biotin carboxylase
SMUFR_RS07955	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMUFR_RS07965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMUFR_RS07970	COG1028	Short-chain dehydrogenase reductase Sdr
SMUFR_RS07975	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SMUFR_RS07990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMUFR_RS07995	COG1846	Transcriptional regulator
SMUFR_RS08000	COG1024	Enoyl-CoA hydratase
SMUFR_RS08005	COG0546	phosphoglycolate phosphatase activity
SMUFR_RS08010	COG0527	aspartate kinase activity
SMUFR_RS08085	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SMUFR_RS08145	COG0525	valine-tRNA ligase activity
SMUFR_RS08190	COG1780	Probably involved in ribonucleotide reductase function
SMUFR_RS08195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMUFR_RS08200	COG2137	regulation of response to DNA damage stimulus
SMUFR_RS08205	COG3557	Belongs to the UPF0374 family
SMUFR_RS08265	COG0442	prolyl-tRNA aminoacylation
SMUFR_RS08275	COG4589	Belongs to the CDS family
SMUFR_RS08280	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMUFR_RS08285	COG1862	Preprotein translocase
SMUFR_RS08295	COG0217	transcriptional regulatory protein
SMUFR_RS08300	COG0789	Transcriptional regulator
SMUFR_RS08305	COG1323	Belongs to the UPF0348 family
SMUFR_RS08315	COG2226	methyltransferase
SMUFR_RS08320	COG0799	negative regulation of ribosome biogenesis
SMUFR_RS08325	COG1713	HD superfamily hydrolase involved in NAD metabolism
SMUFR_RS08330	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SMUFR_RS08335	COG1534	Rna-binding protein
SMUFR_RS08340	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SMUFR_RS08345	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SMUFR_RS08365	COG1819	glycosyl
SMUFR_RS08405	COG5002	protein histidine kinase activity
SMUFR_RS08410	COG0745	RESPONSE REGULATOR receiver
SMUFR_RS08420	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMUFR_RS08425	COG0154	amidase activity
SMUFR_RS08430	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMUFR_RS08435	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SMUFR_RS08440	COG1335	isochorismatase
SMUFR_RS08445	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SMUFR_RS08450	COG0436	Aminotransferase
SMUFR_RS08455	COG1268	BioY protein
SMUFR_RS08465	COG0561	phosphatase activity
SMUFR_RS08470	COG0252	asparaginase activity
SMUFR_RS08480	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SMUFR_RS08485	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SMUFR_RS08490	COG0736	holo-[acyl-carrier-protein] synthase activity
SMUFR_RS08495	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SMUFR_RS08500	COG0653	protein targeting
SMUFR_RS08505	COG1482	cell wall glycoprotein biosynthetic process
SMUFR_RS08510	COG1940	carbohydrate kinase activity
SMUFR_RS08515	COG1263	PTS System
SMUFR_RS08515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMUFR_RS08515	COG2190	(PTS) system
SMUFR_RS08520	COG1621	beta-fructofuranosidase activity
SMUFR_RS08525	COG1609	Transcriptional regulator
SMUFR_RS08530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMUFR_RS08540	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SMUFR_RS08545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMUFR_RS08550	COG2131	deaminase
SMUFR_RS08555	COG0006	proline dipeptidase activity
SMUFR_RS08560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SMUFR_RS08595	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SMUFR_RS08600	COG0629	single-stranded DNA binding
SMUFR_RS08605	COG0360	Binds together with S18 to 16S ribosomal RNA
SMUFR_RS08620	COG1194	a g-specific adenine glycosylase
SMUFR_RS08625	COG1063	alcohol dehydrogenase
SMUFR_RS08630	COG3118	belongs to the thioredoxin family
SMUFR_RS08635	COG1193	negative regulation of DNA recombination
SMUFR_RS08650	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SMUFR_RS08655	COG0681	Belongs to the peptidase S26 family
SMUFR_RS08660	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SMUFR_RS08675	COG3715	PTS system
SMUFR_RS08680	COG3716	PTS system mannose fructose sorbose family IID component
SMUFR_RS08685	COG2274	protein secretion by the type I secretion system
SMUFR_RS08705	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SMUFR_RS08720	COG2801	Transposase and inactivated derivatives
SMUFR_RS08740	COG2274	protein secretion by the type I secretion system
SMUFR_RS08745	COG2274	protein secretion by the type I secretion system
SMUFR_RS08800	COG3290	protein histidine kinase activity
SMUFR_RS08810	COG0586	Pfam SNARE associated Golgi protein
SMUFR_RS08820	COG1160	GTP binding
SMUFR_RS08825	COG1484	DNA-dependent DNA replication
SMUFR_RS08835	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SMUFR_RS08840	COG0745	RESPONSE REGULATOR receiver
SMUFR_RS08855	COG1136	(ABC) transporter
SMUFR_RS08860	COG4591	ABC-type transport system involved in lipoprotein release permease component
SMUFR_RS08865	COG0501	Belongs to the peptidase M48B family
SMUFR_RS08870	COG1704	LemA family
SMUFR_RS08875	COG0357	Ribosomal RNA small subunit methyltransferase G
SMUFR_RS08885	COG1122	ATPase activity
SMUFR_RS08890	COG4720	Psort location CytoplasmicMembrane, score
SMUFR_RS08900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMUFR_RS08910	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SMUFR_RS08915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMUFR_RS08920	COG1464	Belongs to the NlpA lipoprotein family
SMUFR_RS08925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUFR_RS08930	COG0495	leucyl-tRNA aminoacylation
SMUFR_RS08960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMUFR_RS08965	COG0564	pseudouridine synthase activity
SMUFR_RS08975	COG0459	protein refolding
SMUFR_RS08980	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SMUFR_RS08990	COG3716	PTS system mannose fructose sorbose family IID component
SMUFR_RS08995	COG3715	PTS system
SMUFR_RS09020	COG2197	response regulator
SMUFR_RS09025	COG4585	Histidine kinase
SMUFR_RS09045	COG1846	Transcriptional regulator
SMUFR_RS09050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMUFR_RS09055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMUFR_RS09065	COG1363	Peptidase, m42
SMUFR_RS09070	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SMUFR_RS09090	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SMUFR_RS09095	COG0827	DNA restriction-modification system
SMUFR_RS09125	COG1459	type II secretion system
SMUFR_RS09130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SMUFR_RS09140	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SMUFR_RS09145	COG0085	RNA polymerase activity
SMUFR_RS09150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMUFR_RS09155	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SMUFR_RS09160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SMUFR_RS09165	COG1121	(ABC) transporter
SMUFR_RS09175	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SMUFR_RS09215	COG0203	ribosomal protein L17
SMUFR_RS09220	COG0202	RNA polymerase activity
SMUFR_RS09225	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SMUFR_RS09230	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SMUFR_RS09240	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SMUFR_RS09245	COG0563	adenylate kinase activity
SMUFR_RS09250	COG0201	protein transport
SMUFR_RS09255	COG0200	Binds to the 23S rRNA
SMUFR_RS09260	COG1841	ribosomal large subunit assembly
SMUFR_RS09265	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SMUFR_RS09275	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SMUFR_RS09280	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SMUFR_RS09285	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SMUFR_RS09290	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SMUFR_RS09295	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SMUFR_RS09300	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SMUFR_RS09305	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SMUFR_RS09310	COG0255	Belongs to the universal ribosomal protein uL29 family
SMUFR_RS09315	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SMUFR_RS09320	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SMUFR_RS09325	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SMUFR_RS09335	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SMUFR_RS09340	COG0089	rRNA binding
SMUFR_RS09350	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SMUFR_RS09355	COG0051	transcription antitermination factor activity, RNA binding
SMUFR_RS09365	COG1621	beta-fructofuranosidase activity
SMUFR_RS09370	COG0542	response to heat
SMUFR_RS09375	COG4463	regulation of RNA biosynthetic process
SMUFR_RS09380	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SMUFR_RS09385	COG0052	Belongs to the universal ribosomal protein uS2 family
SMUFR_RS09400	COG1619	proteins homologs of microcin C7 resistance protein MccF
SMUFR_RS09405	COG3590	peptidase
SMUFR_RS09410	COG0366	Alpha amylase catalytic
SMUFR_RS09415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMUFR_RS09415	COG1263	PTS System
SMUFR_RS09420	COG2188	Transcriptional regulator
SMUFR_RS09425	COG5297	Belongs to the glycosyl hydrolase family 6
SMUFR_RS09430	COG1490	D-aminoacyl-tRNA deacylase activity
SMUFR_RS09445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMUFR_RS09445	COG2190	(PTS) system
SMUFR_RS09445	COG1263	PTS System
SMUFR_RS09450	COG1609	Transcriptional regulator
SMUFR_RS09455	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SMUFR_RS09460	COG2264	protein methyltransferase activity
SMUFR_RS09480	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SMUFR_RS09490	COG2217	Heavy metal translocating P-type atpase
SMUFR_RS09500	COG2855	membrane
SMUFR_RS09505	COG0583	DNA-binding transcription factor activity
SMUFR_RS09515	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SMUFR_RS09525	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SMUFR_RS09535	COG0463	Glycosyl transferase, family 2
SMUFR_RS09540	COG0428	transporter
SMUFR_RS09545	COG3022	response to hydroperoxide
SMUFR_RS09580	COG3906	Belongs to the UPF0473 family
SMUFR_RS09585	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SMUFR_RS09590	COG4472	Bacterial protein of unknown function (DUF965)
SMUFR_RS09610	COG1393	Belongs to the ArsC family
SMUFR_RS09615	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SMUFR_RS09620	COG1058	Belongs to the CinA family
SMUFR_RS09620	COG1546	Belongs to the CinA family
SMUFR_RS09625	COG0519	Catalyzes the synthesis of GMP from XMP
SMUFR_RS09630	COG0632	four-way junction helicase activity
SMUFR_RS09635	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SMUFR_RS09645	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SMUFR_RS09655	COG1438	arginine binding
SMUFR_RS09675	COG0018	arginyl-trna synthetase
SMUFR_RS09680	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SMUFR_RS09685	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SMUFR_RS09690	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SMUFR_RS09695	COG0124	histidyl-tRNA synthetase
SMUFR_RS09700	COG0531	amino acid
SMUFR_RS09705	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SMUFR_RS09710	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMUFR_RS09725	COG0640	Transcriptional regulator
SMUFR_RS09730	COG2814	Major facilitator Superfamily
SMUFR_RS09750	COG0789	Transcriptional regulator
SMUFR_RS09755	COG1028	Short-chain dehydrogenase reductase Sdr
SMUFR_RS09780	COG2094	Belongs to the DNA glycosylase MPG family
SMUFR_RS09795	COG1733	regulation of RNA biosynthetic process
SMUFR_RS09805	COG1012	belongs to the aldehyde dehydrogenase family
SMUFR_RS09810	COG0129	dihydroxy-acid dehydratase activity
SMUFR_RS09815	COG2151	metal-sulfur cluster biosynthetic enzyme
SMUFR_RS09835	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMUFR_RS09845	COG0305	Participates in initiation and elongation during chromosome replication
SMUFR_RS09850	COG0359	binds to the 23S rRNA
SMUFR_RS09860	COG0445	tRNA wobble uridine modification
SMUFR_RS09870	COG0482	sulfurtransferase activity
SMUFR_RS09875	COG0741	lytic transglycosylase activity
SMUFR_RS09885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SMUFR_RS09890	COG1122	ATPase activity
SMUFR_RS09895	COG1122	ATPase activity
SMUFR_RS09900	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SMUFR_RS09910	COG0612	Peptidase, M16
SMUFR_RS09925	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SMUFR_RS09930	COG0516	GMP reductase activity
SMUFR_RS09930	COG0517	IMP dehydrogenase activity
SMUFR_RS09935	COG0180	Tryptophanyl-tRNA synthetase
SMUFR_RS09940	COG0488	(ABC) transporter
SMUFR_RS09970	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SMUFR_RS09975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMUFR_RS09980	COG1475	DNA binding