locus-tag	class	description
SMU_01	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SMU_02	COG0592	DNA-directed DNA polymerase activity
SMU_06	COG0012	GTP binding
SMU_07	COG0193	aminoacyl-tRNA hydrolase activity
SMU_08	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SMU_09	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SMU_1001	COG0758	DNA mediated transformation
SMU_1002	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMU_1003	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SMU_1004	COG0366	Alpha amylase catalytic
SMU_1004	COG5263	repeat protein
SMU_1005	COG5263	repeat protein
SMU_1005	COG0366	Alpha amylase catalytic
SMU_1006	COG1136	(ABC) transporter
SMU_1008	COG0745	RESPONSE REGULATOR receiver
SMU_1009	COG0642	Histidine kinase
SMU_101	COG3715	PTS system
SMU_1010	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SMU_1011	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
SMU_1013c	COG2851	Citrate transporter
SMU_1016	COG0511	ligase activity, forming carbon-carbon bonds
SMU_1017	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SMU_1019	COG3052	prosthetic group binding
SMU_1024c	COG2801	Transposase and inactivated derivatives
SMU_1034c	COG4974	Belongs to the 'phage' integrase family
SMU_1035	COG1131	(ABC) transporter
SMU_1037c	COG5002	protein histidine kinase activity
SMU_1038c	COG0745	RESPONSE REGULATOR receiver
SMU_1039c	COG1442	glycosyl transferase family 8
SMU_1040c	COG4221	oxidoreductase activity
SMU_1041	COG1131	(ABC) transporter
SMU_1043c	COG0280	phosphate acetyltransferase
SMU_1044c	COG0564	pseudouridine synthase activity
SMU_1045c	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SMU_1046c	COG2357	RelA SpoT domain protein
SMU_1048	COG4116	CYTH
SMU_1050	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMU_1051	COG1104	cysteine desulfurase activity
SMU_1053	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SMU_1054	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SMU_1060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SMU_1061	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SMU_1063	COG4175	Glycine betaine
SMU_1063	COG3448	diguanylate cyclase activity
SMU_1065c	COG2188	Transcriptional regulator
SMU_1066	COG0519	Catalyzes the synthesis of GMP from XMP
SMU_1068c	COG1131	(ABC) transporter
SMU_1072c	COG1247	-acetyltransferase
SMU_1073	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SMU_1075	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SMU_1076	COG4684	Psort location CytoplasmicMembrane, score
SMU_1077	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMU_1078c	COG1132	(ABC) transporter
SMU_1079c	COG1132	(ABC) transporter
SMU_1082	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMU_1083c	COG0009	L-threonylcarbamoyladenylate synthase
SMU_1084	COG2890	protein-(glutamine-N5) methyltransferase activity
SMU_1085	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SMU_1086	COG1435	thymidine kinase activity
SMU_1087	COG1942	4-Oxalocrotonate Tautomerase
SMU_1090	COG3976	FMN-binding domain protein
SMU_1090	COG1053	succinate dehydrogenase
SMU_1090	COG0431	NADPH-dependent FMN reductase
SMU_1093	COG0577	efflux transmembrane transporter activity
SMU_1094	COG1136	(ABC) transporter
SMU_1095	COG1174	glycine betaine transport
SMU_1098c	COG1063	alcohol dehydrogenase
SMU_110	COG1396	sequence-specific DNA binding
SMU_1100c	COG0628	permease
SMU_1102	COG2723	6-phospho-beta-galactosidase activity
SMU_1104c	COG0588	phosphoglycerate mutase activity
SMU_1105c	COG0406	alpha-ribazole phosphatase activity
SMU_1108c	COG0561	phosphatase activity
SMU_1112c	COG0346	lactoylglutathione lyase activity
SMU_1113	COG3764	Sortase (surface protein transpeptidase)
SMU_1115	COG0039	L-malate dehydrogenase activity
SMU_1118c	COG1079	Belongs to the binding-protein-dependent transport system permease family
SMU_1119c	COG4603	Belongs to the binding-protein-dependent transport system permease family
SMU_1120	COG3845	ABC transporter
SMU_1121c	COG1744	ABC transporter substrate-binding protein PnrA-like
SMU_1122	COG0295	cytidine deaminase activity
SMU_1123	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SMU_1124	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SMU_1125c	COG2813	Specifically methylates the guanine in position
SMU_1126	COG1072	(Pantothenic acid kinase))
SMU_1127	COG0268	Binds directly to 16S ribosomal RNA
SMU_1128	COG5002	protein histidine kinase activity
SMU_1129	COG0745	RESPONSE REGULATOR receiver
SMU_113	COG1105	Belongs to the carbohydrate kinase PfkB family
SMU_1133	COG0704	Plays a role in the regulation of phosphate uptake
SMU_1134c	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SMU_1135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SMU_1136	COG0581	inorganic phosphate transmembrane transporter activity
SMU_1137	COG0573	inorganic phosphate transmembrane transporter activity
SMU_1139c	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SMU_1139c	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SMU_114	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMU_114	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMU_114	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMU_1140c	COG0483	inositol monophosphate 1-phosphatase activity
SMU_1141c	COG4476	Belongs to the UPF0223 family
SMU_1142c	COG1393	Belongs to the ArsC family
SMU_1143c	COG0196	riboflavin kinase activity
SMU_1144	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SMU_1145c	COG2205	protein histidine kinase activity
SMU_1146c	COG0745	RESPONSE REGULATOR receiver
SMU_115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMU_115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMU_115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMU_116	COG3684	Belongs to the aldolase LacD family
SMU_1163c	COG1132	(ABC) transporter
SMU_1164c	COG2375	cellular response to nickel ion
SMU_1164c	COG1132	(ABC) transporter
SMU_1169c	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMU_1170	COG0785	Cytochrome C biogenesis protein
SMU_1173	COG2873	o-acetylhomoserine
SMU_1174	COG0210	DNA helicase
SMU_1175	COG1115	amino acid carrier protein
SMU_1176	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SMU_1177c	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMU_1178c	COG1126	abc transporter atp-binding protein
SMU_1179c	COG0765	amino acid transport
SMU_1180	COG2824	Alkylphosphonate utilization operon protein PhnA
SMU_1182	COG0246	Mannitol dehydrogenase
SMU_1183	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMU_1184c	COG3711	transcriptional antiterminator
SMU_1185	COG2213	PTS system mannitol-specific
SMU_1187	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMU_1189c	COG2261	transglycosylase associated protein
SMU_1190	COG0469	pyruvate kinase activity
SMU_1191	COG0205	6-phosphofructokinase activity
SMU_1193	COG1725	Transcriptional regulator
SMU_1194	COG1131	(ABC) transporter
SMU_120	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SMU_1200	COG0539	negative regulation of cytoplasmic translation
SMU_1203	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SMU_1207	COG2184	nucleotidyltransferase activity
SMU_121	COG0534	Mate efflux family protein
SMU_1210	COG0187	DNA topoisomerase II activity
SMU_1211	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SMU_1213c	COG0737	Belongs to the 5'-nucleotidase family
SMU_1215	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SMU_1216c	COG0765	amino acid transport
SMU_1217c	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMU_1219c	COG2315	Protein conserved in bacteria
SMU_1220c	COG1881	PFAM PEBP family protein
SMU_1221	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SMU_1222	COG0284	orotidine-5'-phosphate decarboxylase activity
SMU_1223	COG0167	dihydroorotate dehydrogenase activity
SMU_1224	COG0543	2 iron, 2 sulfur cluster binding
SMU_1227	COG0813	purine-nucleoside phosphorylase activity
SMU_123	COG2176	DNA-directed DNA polymerase activity
SMU_1233	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SMU_1234	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SMU_1235	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SMU_1238c	COG1573	uracil-dna glycosylase
SMU_1239	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMU_124	COG1846	Transcriptional regulator
SMU_1241	COG0322	excinuclease ABC activity
SMU_1245c	COG1011	Hydrolase
SMU_1247	COG0148	phosphopyruvate hydratase activity
SMU_125	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SMU_1263	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SMU_1264	COG0107	imidazoleglycerol-phosphate synthase activity
SMU_1265	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SMU_1266	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SMU_1268	COG0131	Imidazoleglycerol-phosphate dehydratase
SMU_1269	COG0560	Phosphoserine phosphatase
SMU_127	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SMU_1270	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SMU_1271	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SMU_1272	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SMU_1273	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMU_1276c	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SMU_1279c	COG0772	Belongs to the SEDS family
SMU_128	COG0022	dehydrogenase e1 component
SMU_128	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMU_1286c	COG2814	Major facilitator Superfamily
SMU_1288	COG0335	large ribosomal subunit rRNA binding
SMU_1289c	COG0038	chloride channel
SMU_1290c	COG0038	chloride channel
SMU_1291c	COG0077	Prephenate dehydratase
SMU_1291c	COG1605	Chorismate mutase
SMU_1294	COG0716	FMN binding
SMU_1295	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMU_1296	COG0625	glutathione transferase activity
SMU_1297	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SMU_1298	COG0254	rRNA binding
SMU_13	COG0037	tRNA processing
SMU_1301c	COG2226	methyltransferase
SMU_1304c	COG1481	regulation of sporulation
SMU_1306c	COG1660	Displays ATPase and GTPase activities
SMU_1308	COG0251	oxidation-reduction process
SMU_1309c	COG0371	Dehydrogenase
SMU_131	COG0095	Lipoate-protein ligase
SMU_1311	COG0017	Asparaginyl-tRNA synthetase
SMU_1312	COG0436	Aminotransferase
SMU_1313c	COG1199	ATP-dependent helicase activity
SMU_1313c	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SMU_1315c	COG1122	ATPase activity
SMU_132	COG1473	amidohydrolase
SMU_1324	COG2177	Part of the ABC transporter FtsEX involved in
SMU_1325	COG2884	Cell division ATP-binding protein ftsE
SMU_1327c	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SMU_133c	COG0477	Major facilitator Superfamily
SMU_134	COG1309	transcriptional regulator
SMU_1348c	COG1136	(ABC) transporter
SMU_135	COG0583	DNA-binding transcription factor activity
SMU_1353	COG2801	Transposase and inactivated derivatives
SMU_1361c	COG1309	transcriptional regulator
SMU_1366c	COG1136	(ABC) transporter
SMU_1367c	COG2226	methyltransferase
SMU_137	COG0281	malic enzyme
SMU_1370c	COG2801	Transposase and inactivated derivatives
SMU_1375c	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SMU_1375c	COG0456	acetyltransferase
SMU_138	COG0679	Auxin Efflux Carrier
SMU_1380	COG2801	Transposase and inactivated derivatives
SMU_1381	COG0066	3-isopropylmalate dehydratase activity
SMU_1382	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SMU_1383	COG0473	3-isopropylmalate dehydrogenase activity
SMU_1386	COG0572	uridine kinase
SMU_1387	COG0673	inositol 2-dehydrogenase activity
SMU_1389	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SMU_139	COG2140	Oxalate decarboxylase
SMU_1394	COG0481	GTPase activity
SMU_1398	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SMU_14	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SMU_1403c	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SMU_1404c	COG1518	maintenance of DNA repeat elements
SMU_1405c	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
SMU_1407c	COG2801	Transposase and inactivated derivatives
SMU_1410	COG3976	FMN-binding domain protein
SMU_1410	COG1053	succinate dehydrogenase
SMU_1412c	COG1136	(ABC) transporter
SMU_1412c	COG0577	efflux transmembrane transporter activity
SMU_1415c	COG0647	UMP catabolic process
SMU_1416c	COG1051	belongs to the nudix hydrolase family
SMU_1418	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMU_1420	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMU_1421	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMU_1422	COG0022	dehydrogenase e1 component
SMU_1423	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SMU_1425	COG0542	response to heat
SMU_1426c	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMU_1428c	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SMU_1429	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SMU_1430	COG3442	glutamine amidotransferase
SMU_1431c	COG0488	(ABC) transporter
SMU_1434c	COG1215	transferase activity, transferring glycosyl groups
SMU_1437	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SMU_143c	COG0242	peptide deformylase activity
SMU_1442c	COG4808	Protein conserved in bacteria
SMU_1445c	COG3842	ATPase activity
SMU_1449	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SMU_144c	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMU_1450	COG1113	amino acid transport
SMU_1451	COG3527	Alpha-acetolactate decarboxylase
SMU_1452	COG0028	Belongs to the TPP enzyme family
SMU_1454c	COG0628	permease
SMU_1455	COG1051	belongs to the nudix hydrolase family
SMU_1457	COG1088	dTDP-glucose 4,6-dehydratase activity
SMU_1461	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SMU_1462c	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMU_1464c	COG2384	SAM-dependent methyltransferase
SMU_1466	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SMU_1467	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMU_1471c	COG2378	regulation of single-species biofilm formation
SMU_1472	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SMU_1472	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SMU_1473c	COG0300	oxidoreductase activity
SMU_1474c	COG1234	tRNA 3'-trailer cleavage
SMU_1476c	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SMU_1477	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SMU_148	COG1012	belongs to the aldehyde dehydrogenase family
SMU_148	COG1454	alcohol dehydrogenase
SMU_1485c	COG1401	restriction endodeoxyribonuclease activity
SMU_1490	COG2723	6-phospho-beta-galactosidase activity
SMU_1491	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMU_1491	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMU_1492	COG1447	Phosphotransferase system cellobiose-specific component IIA
SMU_1493	COG3684	Belongs to the aldolase LacD family
SMU_1494	COG1105	Belongs to the carbohydrate kinase PfkB family
SMU_1495	COG0698	ribose 5-phosphate isomerase
SMU_1496	COG0698	ribose 5-phosphate isomerase
SMU_1498	COG1349	DNA-binding transcription factor activity
SMU_1499	COG1074	ATP-dependent DNA helicase activity
SMU_15	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMU_1500	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SMU_1508c	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SMU_1509	COG1396	sequence-specific DNA binding
SMU_1510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMU_1510	COG0072	phenylalanine-tRNA ligase activity
SMU_1512	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SMU_1513	COG1196	nuclear chromosome segregation
SMU_1514	COG0571	ribonuclease III activity
SMU_1515	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SMU_1516	COG5002	protein histidine kinase activity
SMU_1517	COG0745	RESPONSE REGULATOR receiver
SMU_1519	COG1126	abc transporter atp-binding protein
SMU_1520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMU_1521	COG0765	amino acid transport
SMU_1522	COG0765	amino acid transport
SMU_1525	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMU_1527	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SMU_1528	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SMU_1529	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SMU_1530	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SMU_1531	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMU_1532	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SMU_1533	COG0356	it plays a direct role in the translocation of protons across the membrane
SMU_1535	COG0058	SHG alpha-glucan phosphorylase activity
SMU_1536	COG0297	glycogen (starch) synthase activity
SMU_1537	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SMU_1538	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SMU_1539	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SMU_154	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SMU_1541	COG1523	belongs to the glycosyl hydrolase 13 family
SMU_1542c	COG1597	lipid kinase activity
SMU_1543	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMU_1545c	COG4708	membrane
SMU_1547c	COG2197	response regulator
SMU_1548c	COG4585	Histidine kinase
SMU_155	COG1185	polyribonucleotide nucleotidyltransferase activity
SMU_1551c	COG1131	(ABC) transporter
SMU_1555c	COG1295	ribonuclease BN
SMU_1557c	COG4109	DRTGG domain
SMU_1562	COG0569	domain protein
SMU_1563	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SMU_1564	COG0058	SHG alpha-glucan phosphorylase activity
SMU_1565	COG1640	4-alpha-glucanotransferase
SMU_1566	COG1609	Transcriptional regulator
SMU_1569	COG1175	transmembrane transport
SMU_157	COG1045	serine acetyltransferase
SMU_1570	COG3833	ABC-type maltose transport systems, permease component
SMU_1571	COG3842	ATPase activity
SMU_1572	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMU_1573	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SMU_1577c	COG5290	Psort location Cytoplasmic, score
SMU_158	COG0215	cysteine-tRNA ligase activity
SMU_1581	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SMU_1582c	COG1956	GAF domain-containing protein
SMU_1584c	COG4716	Myosin-crossreactive antigen
SMU_1586	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMU_1588c	COG0438	transferase activity, transferring glycosyl groups
SMU_159	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SMU_1591	COG1609	Transcriptional regulator
SMU_1596	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMU_1598	COG1447	Phosphotransferase system cellobiose-specific component IIA
SMU_1599	COG3711	transcriptional antiterminator
SMU_1599	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMU_16	COG0531	amino acid
SMU_160	COG5504	Zn-dependent protease
SMU_1600	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMU_1601	COG2723	6-phospho-beta-galactosidase activity
SMU_1602	COG0778	Nitroreductase
SMU_1603	COG0346	lactoylglutathione lyase activity
SMU_1605	COG2814	Major facilitator Superfamily
SMU_1606	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SMU_1607	COG0557	exoribonuclease II activity
SMU_1610	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMU_1611c	COG2814	Major facilitator Superfamily
SMU_1612c	COG2264	protein methyltransferase activity
SMU_1613c	COG0237	dephospho-CoA kinase activity
SMU_1614	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SMU_1617	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SMU_1618	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SMU_1619c	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SMU_1620	COG1702	phosphate starvation-inducible protein PhoH
SMU_1621c	COG4479	Belongs to the UPF0346 family
SMU_1622	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMU_1624	COG0233	cytoplasmic translational termination
SMU_1625	COG0528	UMP kinase activity
SMU_1626	COG0081	regulation of translation
SMU_1627	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SMU_1629c	COG1674	ftsk spoiiie
SMU_1635	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SMU_1639	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMU_1639	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMU_164	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMU_1647c	COG0640	Transcriptional regulator
SMU_1649	COG0708	Exodeoxyribonuclease III
SMU_1650	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SMU_1651	COG1393	Belongs to the ArsC family
SMU_1652	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMU_1653	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMU_1656	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SMU_1657c	COG0347	Belongs to the P(II) protein family
SMU_1658	COG0004	ammonium transporteR
SMU_1660c	COG4467	Involved in initiation control of chromosome replication
SMU_1661c	COG1774	PSP1 C-terminal conserved region
SMU_1662	COG0470	DNA polymerase III
SMU_1663	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SMU_1664c	COG0517	IMP dehydrogenase activity
SMU_1668	COG0559	Belongs to the binding-protein-dependent transport system permease family
SMU_1670c	COG4471	UPF0298 protein
SMU_1672	COG0740	serine-type endopeptidase activity
SMU_1673	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SMU_1674	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SMU_1675	COG0626	cystathionine gamma-synthase activity
SMU_1676c	COG2244	polysaccharide biosynthetic process
SMU_1677	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SMU_168	COG1476	TRANSCRIPTIONal
SMU_1682c	COG0693	protein deglycase activity
SMU_1683c	COG2378	regulation of single-species biofilm formation
SMU_1687	COG1227	inorganic diphosphatase activity
SMU_1688	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SMU_1689	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMU_169	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SMU_1690	COG1696	Membrane protein involved in D-alanine export
SMU_1691	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMU_1692	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SMU_1693	COG1253	flavin adenine dinucleotide binding
SMU_1694c	COG0628	permease
SMU_1695	COG1119	ATPase activity
SMU_1697c	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SMU_1699c	COG1242	4 iron, 4 sulfur cluster binding
SMU_170	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SMU_1700c	COG1346	cytolysis
SMU_1702c	COG0671	phosphoesterase, PA-phosphatase related
SMU_1703c	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SMU_1708	COG0569	domain protein
SMU_1709	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SMU_1710c	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SMU_1711	COG1187	pseudouridine synthase activity
SMU_1712c	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SMU_1713c	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SMU_1714c	COG0582	viral genome integration into host DNA
SMU_1717c	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SMU_1718	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SMU_1719c	COG3763	UPF0154 protein
SMU_1721c	COG0019	diaminopimelate decarboxylase activity
SMU_1724c	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMU_1725	COG1254	Belongs to the acylphosphatase family
SMU_1727	COG0706	membrane insertase activity
SMU_1728	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMU_1729c	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SMU_1731	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SMU_1733c	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SMU_1736	COG0439	Biotin carboxylase
SMU_1737	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMU_1739	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMU_1740	COG1028	Short-chain dehydrogenase reductase Sdr
SMU_1741	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SMU_1744	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMU_1745c	COG1846	Transcriptional regulator
SMU_1746c	COG1024	Enoyl-CoA hydratase
SMU_1747c	COG0546	phosphoglycolate phosphatase activity
SMU_1748	COG0527	aspartate kinase activity
SMU_1753c	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SMU_1754c	COG1518	maintenance of DNA repeat elements
SMU_1755c	COG1518	maintenance of DNA repeat elements
SMU_1757c	COG1518	maintenance of DNA repeat elements
SMU_176	COG5433	transposase activity
SMU_177	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMU_1770	COG0525	valine-tRNA ligase activity
SMU_1777	COG1780	Probably involved in ribonucleotide reductase function
SMU_1779c	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMU_1780	COG2137	regulation of response to DNA damage stimulus
SMU_1781	COG3557	Belongs to the UPF0374 family
SMU_1783	COG0442	prolyl-tRNA aminoacylation
SMU_1785	COG4589	Belongs to the CDS family
SMU_1786	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMU_1787c	COG1862	Preprotein translocase
SMU_1789c	COG0217	transcriptional regulatory protein
SMU_179	COG1053	succinate dehydrogenase
SMU_179	COG0431	NADPH-dependent FMN reductase
SMU_179	COG3976	FMN-binding domain protein
SMU_1790c	COG0789	Transcriptional regulator
SMU_1791c	COG1323	Belongs to the UPF0348 family
SMU_1795c	COG2226	methyltransferase
SMU_1797c	COG0799	negative regulation of ribosome biogenesis
SMU_1798c	COG1713	HD superfamily hydrolase involved in NAD metabolism
SMU_1799	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SMU_180	COG3976	FMN-binding domain protein
SMU_180	COG1053	succinate dehydrogenase
SMU_180	COG0431	NADPH-dependent FMN reductase
SMU_1800c	COG1534	Rna-binding protein
SMU_1801c	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SMU_1802c	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SMU_1806	COG1819	glycosyl
SMU_181	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SMU_1814	COG5002	protein histidine kinase activity
SMU_1815	COG0745	RESPONSE REGULATOR receiver
SMU_1817c	COG3344	reverse transcriptase
SMU_1819	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMU_1820c	COG0154	amidase activity
SMU_1821c	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMU_1822	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SMU_1823	COG1335	isochorismatase
SMU_1824c	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SMU_1826	COG0436	Aminotransferase
SMU_1827	COG1268	BioY protein
SMU_1830c	COG0561	phosphatase activity
SMU_1831	COG0252	asparaginase activity
SMU_1833	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SMU_1834	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SMU_1835	COG0736	holo-[acyl-carrier-protein] synthase activity
SMU_1836	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SMU_1837	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SMU_1838	COG0653	protein targeting
SMU_1839	COG1482	cell wall glycoprotein biosynthetic process
SMU_184	COG0803	Belongs to the bacterial solute-binding protein 9 family
SMU_1840	COG1940	carbohydrate kinase activity
SMU_1841	COG1263	PTS System
SMU_1841	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMU_1841	COG2190	(PTS) system
SMU_1843	COG1621	beta-fructofuranosidase activity
SMU_1844	COG1609	Transcriptional regulator
SMU_1845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMU_1847	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SMU_1848	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMU_1849	COG2131	deaminase
SMU_1850	COG0006	proline dipeptidase activity
SMU_1851	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SMU_1858	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SMU_1859	COG0629	single-stranded DNA binding
SMU_1860	COG0360	Binds together with S18 to 16S ribosomal RNA
SMU_1865	COG1194	a g-specific adenine glycosylase
SMU_1867c	COG1063	alcohol dehydrogenase
SMU_1869	COG3118	belongs to the thioredoxin family
SMU_1870	COG1193	negative regulation of DNA recombination
SMU_1873	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SMU_1874	COG0681	Belongs to the peptidase S26 family
SMU_1875	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SMU_1878	COG3715	PTS system
SMU_1879	COG3716	PTS system mannose fructose sorbose family IID component
SMU_187c	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SMU_1881c	COG2274	protein secretion by the type I secretion system
SMU_1886	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SMU_188c	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SMU_1893c	COG2801	Transposase and inactivated derivatives
SMU_1897	COG2274	protein secretion by the type I secretion system
SMU_1898	COG2274	protein secretion by the type I secretion system
SMU_1899	COG2274	protein secretion by the type I secretion system
SMU_1916	COG3290	protein histidine kinase activity
SMU_1918	COG0586	Pfam SNARE associated Golgi protein
SMU_1920	COG1160	GTP binding
SMU_1921	COG1484	DNA-dependent DNA replication
SMU_1923c	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SMU_1924	COG0745	RESPONSE REGULATOR receiver
SMU_1927	COG1136	(ABC) transporter
SMU_1928	COG4591	ABC-type transport system involved in lipoprotein release permease component
SMU_1929	COG0501	Belongs to the peptidase M48B family
SMU_1930	COG1704	LemA family
SMU_1931	COG0357	Ribosomal RNA small subunit methyltransferase G
SMU_1934c	COG1122	ATPase activity
SMU_1935c	COG4720	Psort location CytoplasmicMembrane, score
SMU_1937	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMU_1939c	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SMU_1940c	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMU_1941	COG1464	Belongs to the NlpA lipoprotein family
SMU_1942c	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMU_1943	COG0495	leucyl-tRNA aminoacylation
SMU_1949	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMU_1950	COG0564	pseudouridine synthase activity
SMU_1954	COG0459	protein refolding
SMU_1955	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SMU_1957	COG3716	PTS system mannose fructose sorbose family IID component
SMU_1958c	COG3715	PTS system
SMU_1964c	COG2197	response regulator
SMU_1965c	COG4585	Histidine kinase
SMU_1969c	COG1846	Transcriptional regulator
SMU_196c	COG3942	CHAP domain
SMU_196c	COG1705	Flagellar rod assembly protein muramidase FlgJ
SMU_1970c	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMU_1971c	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMU_1973	COG1363	Peptidase, m42
SMU_1974	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SMU_1978	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SMU_1979c	COG0827	DNA restriction-modification system
SMU_1985	COG1459	type II secretion system
SMU_1987	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SMU_1989	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SMU_198c	COG0433	COG0433 Predicted ATPase
SMU_1990	COG0085	RNA polymerase activity
SMU_1991	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMU_1992	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SMU_1993	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SMU_1994	COG1121	(ABC) transporter
SMU_1996	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SMU_20	COG1792	Involved in formation and maintenance of cell shape
SMU_2000	COG0203	ribosomal protein L17
SMU_2001	COG0202	RNA polymerase activity
SMU_2002	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SMU_2003	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SMU_2004	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SMU_2005	COG0563	adenylate kinase activity
SMU_2006	COG0201	protein transport
SMU_2007	COG0200	Binds to the 23S rRNA
SMU_2008	COG1841	ribosomal large subunit assembly
SMU_2009	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SMU_2011	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SMU_2012	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SMU_2014	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SMU_2015	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SMU_2016	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SMU_2017	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SMU_2018	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SMU_2019	COG0255	Belongs to the universal ribosomal protein uL29 family
SMU_2020	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SMU_2021	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SMU_2022	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SMU_2025	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SMU_2028	COG1621	beta-fructofuranosidase activity
SMU_2029	COG0542	response to heat
SMU_2030	COG4463	regulation of RNA biosynthetic process
SMU_2031	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SMU_2032	COG0052	Belongs to the universal ribosomal protein uS2 family
SMU_2035	COG1619	proteins homologs of microcin C7 resistance protein MccF
SMU_2036	COG3590	peptidase
SMU_2037	COG0366	Alpha amylase catalytic
SMU_2038	COG1263	PTS System
SMU_2038	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMU_2040	COG2188	Transcriptional regulator
SMU_2042	COG5297	Belongs to the glycosyl hydrolase family 6
SMU_2043c	COG1490	D-aminoacyl-tRNA deacylase activity
SMU_2047	COG2190	(PTS) system
SMU_2047	COG1263	PTS System
SMU_2047	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMU_2049c	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SMU_2050c	COG2264	protein methyltransferase activity
SMU_2056	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SMU_2057c	COG2217	Heavy metal translocating P-type atpase
SMU_2059c	COG2855	membrane
SMU_2060	COG0583	DNA-binding transcription factor activity
SMU_2063	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SMU_2065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SMU_2067	COG0463	Glycosyl transferase, family 2
SMU_2069	COG0428	transporter
SMU_2070	COG3022	response to hydroperoxide
SMU_2077c	COG3906	Belongs to the UPF0473 family
SMU_2078c	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SMU_2079c	COG4472	Bacterial protein of unknown function (DUF965)
SMU_2084c	COG1393	Belongs to the ArsC family
SMU_2085	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SMU_2086	COG1058	Belongs to the CinA family
SMU_2086	COG1546	Belongs to the CinA family
SMU_2087	COG0519	Catalyzes the synthesis of GMP from XMP
SMU_2088	COG0632	four-way junction helicase activity
SMU_2089	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SMU_208c	COG1674	ftsk spoiiie
SMU_2091c	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SMU_2093	COG1438	arginine binding
SMU_2098	COG0018	arginyl-trna synthetase
SMU_2099c	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SMU_2100c	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SMU_2101	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SMU_2102	COG0124	histidyl-tRNA synthetase
SMU_2104	COG0531	amino acid
SMU_2104a	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SMU_2108c	COG0640	Transcriptional regulator
SMU_2109	COG2814	Major facilitator Superfamily
SMU_2114c	COG0789	Transcriptional regulator
SMU_2115	COG1028	Short-chain dehydrogenase reductase Sdr
SMU_2120c	COG2094	Belongs to the DNA glycosylase MPG family
SMU_2125	COG1733	regulation of RNA biosynthetic process
SMU_2127	COG1012	belongs to the aldehyde dehydrogenase family
SMU_2128	COG0129	dihydroxy-acid dehydratase activity
SMU_2129c	COG2151	metal-sulfur cluster biosynthetic enzyme
SMU_2135c	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMU_2138	COG0305	Participates in initiation and elongation during chromosome replication
SMU_2139c	COG0359	binds to the 23S rRNA
SMU_2143c	COG0482	sulfurtransferase activity
SMU_2146c	COG0741	lytic transglycosylase activity
SMU_2148c	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SMU_2149c	COG1122	ATPase activity
SMU_2150c	COG1122	ATPase activity
SMU_2151	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SMU_2153c	COG0612	Peptidase, M16
SMU_2156	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SMU_2157	COG0517	IMP dehydrogenase activity
SMU_2157	COG0516	GMP reductase activity
SMU_2158c	COG0180	Tryptophanyl-tRNA synthetase
SMU_2159	COG0488	(ABC) transporter
SMU_2162c	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SMU_2164	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMU_2165	COG1475	DNA binding
SMU_2166	COG0089	rRNA binding
SMU_2167	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SMU_218	COG1396	sequence-specific DNA binding
SMU_22	COG3942	CHAP domain
SMU_221c	COG0582	viral genome integration into host DNA
SMU_23	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMU_231	COG0028	Belongs to the TPP enzyme family
SMU_232	COG0440	acetolactate synthase activity
SMU_233	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SMU_234	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SMU_236c	COG1309	transcriptional regulator
SMU_238c	COG1131	(ABC) transporter
SMU_24	COG0436	Aminotransferase
SMU_241c	COG1126	abc transporter atp-binding protein
SMU_242c	COG0765	amino acid transport
SMU_244	COG1968	undecaprenyl-diphosphatase activity
SMU_245	COG4862	establishment of competence for transformation
SMU_246	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMU_248	COG0719	Fe-S assembly protein
SMU_249	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMU_25	COG1381	Involved in DNA repair and RecF pathway recombination
SMU_251	COG0719	Fe-S assembly protein
SMU_255	COG4166	transmembrane transport
SMU_256	COG0601	transmembrane transport
SMU_257	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMU_258	COG0444	Belongs to the ABC transporter superfamily
SMU_259	COG4608	Belongs to the ABC transporter superfamily
SMU_26	COG0416	fatty acid biosynthetic process
SMU_262	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMU_263	COG0531	amino acid
SMU_264	COG2957	Belongs to the agmatine deiminase family
SMU_267c	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMU_267c	COG2918	glutathione biosynthetic process
SMU_268	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SMU_27	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMU_272	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMU_28	COG2274	protein secretion by the type I secretion system
SMU_286	COG2274	protein secretion by the type I secretion system
SMU_29	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SMU_291	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SMU_297	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMU_297	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMU_298	COG1832	CoA-binding protein
SMU_30	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMU_300	COG0343	queuine tRNA-ribosyltransferase activity
SMU_303	COG1234	tRNA 3'-trailer cleavage
SMU_307	COG0166	Belongs to the GPI family
SMU_309	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMU_309	COG3711	transcriptional antiterminator
SMU_311	COG3730	PTS system glucitol sorbitol-specific
SMU_312	COG3732	PTS system glucitol sorbitol-specific
SMU_317	COG2171	N-acyltransferase activity
SMU_318	COG1473	amidohydrolase
SMU_32	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SMU_320	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SMU_321	COG0705	Rhomboid family
SMU_321	COG0457	Tetratricopeptide repeat
SMU_322c	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SMU_323	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SMU_325	COG0756	dUTP diphosphatase activity
SMU_330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMU_331	COG1827	regulation of RNA biosynthetic process
SMU_334	COG0137	argininosuccinate synthase activity
SMU_335	COG0165	Argininosuccinate lyase
SMU_336	COG0594	ribonuclease P activity
SMU_337	COG0706	membrane insertase activity
SMU_34	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SMU_340	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SMU_341	COG0084	hydrolase, TatD family'
SMU_349	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SMU_35	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SMU_351	COG1162	GTPase activity
SMU_356	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMU_357	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SMU_358	COG0049	tRNA binding
SMU_359	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SMU_361	COG0126	phosphoglycerate kinase activity
SMU_363	COG0789	Transcriptional regulator
SMU_364	COG0174	glutamine synthetase
SMU_365	COG0070	glutamate synthase
SMU_365	COG0069	glutamate synthase activity
SMU_365	COG0067	glutamate synthase
SMU_366	COG0493	'glutamate synthase
SMU_367	COG3942	CHAP domain
SMU_369c	COG5503	Protein of unknown function (DUF1447)
SMU_37	COG0138	bifunctional purine biosynthesis protein purh
SMU_373	COG2226	methyltransferase
SMU_376	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMU_382c	COG0667	Aldo Keto reductase
SMU_383c	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMU_385	COG1214	PFAM Peptidase M22, glycoprotease
SMU_386	COG0456	acetyltransferase
SMU_387	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SMU_392c	COG2081	HI0933 family
SMU_394c	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SMU_395	COG2936	dipeptidyl-peptidase activity
SMU_400	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMU_402	COG1882	Formate acetyltransferase
SMU_403	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMU_406c	COG0561	phosphatase activity
SMU_408	COG2252	PERMEase
SMU_409	COG0802	atpase or kinase
SMU_410	COG1316	TRANSCRIPTIONal
SMU_412c	COG0537	adenosine 5'-monophosphoramidase activity
SMU_413	COG1131	(ABC) transporter
SMU_414	COG4473	ABC transporter
SMU_416	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SMU_417	COG0779	Required for maturation of 30S ribosomal subunits
SMU_418	COG0195	Participates in both transcription termination and antitermination
SMU_419	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SMU_421	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SMU_422	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SMU_426	COG2217	Heavy metal translocating P-type atpase
SMU_428	COG0561	phosphatase activity
SMU_436c	COG2801	Transposase and inactivated derivatives
SMU_438c	COG1924	4 iron, 4 sulfur cluster binding
SMU_442	COG1673	EVE domain
SMU_445	COG0752	glycyl-tRNA synthetase alpha subunit
SMU_446	COG0751	glycine-tRNA ligase activity
SMU_447	COG4224	UPF0291 protein
SMU_449	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SMU_450	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SMU_453	COG0275	rRNA processing
SMU_454	COG4839	cell division protein FtsL
SMU_455	COG0768	penicillin binding
SMU_456	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMU_458	COG0513	Belongs to the DEAD box helicase family
SMU_461	COG1126	abc transporter atp-binding protein
SMU_463	COG0492	ferredoxin-NADP+ reductase activity
SMU_464	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SMU_465	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMU_466	COG3579	cysteine-type endopeptidase activity
SMU_467	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMU_469	COG3331	DNA recombination
SMU_470	COG4474	Belongs to the UPF0398 family
SMU_471	COG3599	regulation of cell shape
SMU_472	COG0116	Belongs to the methyltransferase superfamily
SMU_474	COG1854	S-ribosylhomocysteine lyase activity
SMU_475	COG4372	Transposase
SMU_475	COG1418	mRNA catabolic process
SMU_478	COG0194	GDP metabolic process
SMU_479	COG1758	RNA polymerase activity
SMU_480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SMU_481	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SMU_482	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMU_482	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SMU_486	COG4585	Histidine kinase
SMU_487	COG2197	response regulator
SMU_489	COG1098	S1 RNA binding domain
SMU_490	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SMU_491	COG1349	DNA-binding transcription factor activity
SMU_493	COG1882	Formate acetyltransferase
SMU_497c	COG1739	Uncharacterized protein family UPF0029
SMU_498	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SMU_499	COG1040	competence protein
SMU_50	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SMU_507	COG1349	DNA-binding transcription factor activity
SMU_508	COG0561	phosphatase activity
SMU_515	COG4716	Myosin-crossreactive antigen
SMU_516	COG0742	ribosomal rna small subunit methyltransferase
SMU_517	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SMU_518	COG3480	Lon protease (S16) C-terminal proteolytic domain
SMU_520	COG0737	Belongs to the 5'-nucleotidase family
SMU_521	COG4470	Protein conserved in bacteria
SMU_522	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SMU_524	COG1132	(ABC) transporter
SMU_525	COG1132	(ABC) transporter
SMU_527	COG3804	dihydrodipicolinate reductase
SMU_532	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SMU_533	COG0512	Glutamine amidotransferase of anthranilate synthase
SMU_534	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SMU_535	COG0134	indole-3-glycerol-phosphate synthase activity
SMU_536	COG0135	phosphoribosylanthranilate isomerase activity
SMU_537	COG0133	tryptophan synthase activity
SMU_538	COG0159	tryptophan synthase activity
SMU_54	COG1794	racemase activity, acting on amino acids and derivatives
SMU_540	COG0783	Belongs to the Dps family
SMU_542	COG1940	carbohydrate kinase activity
SMU_543	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SMU_546	COG1217	gtp-binding protein TYPA
SMU_548	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SMU_549	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SMU_553	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SMU_554	COG1799	cell septum assembly
SMU_556	COG2302	S4 RNA-binding domain
SMU_557	COG3599	regulation of cell shape
SMU_558	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SMU_562	COG0542	response to heat
SMU_563	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMU_564	COG4703	Protein of unknown function (DUF1797)
SMU_565c	COG2801	Transposase and inactivated derivatives
SMU_567	COG0765	amino acid transport
SMU_568	COG1126	abc transporter atp-binding protein
SMU_572	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SMU_573	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SMU_574c	COG1346	cytolysis
SMU_575c	COG1380	Effector of murein hydrolase LrgA
SMU_576	COG3279	Response regulator of the LytR AlgR family
SMU_577	COG3275	phosphorelay sensor kinase activity
SMU_580	COG1570	exodeoxyribonuclease VII activity
SMU_581	COG1722	exodeoxyribonuclease VII activity
SMU_583	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SMU_584	COG1438	arginine binding
SMU_585	COG0497	DNA recombination
SMU_586	COG1307	EDD domain protein, DegV family
SMU_587	COG2755	lipolytic protein G-D-S-L family
SMU_589	COG0776	regulation of translation
SMU_59	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMU_590c	COG2801	Transposase and inactivated derivatives
SMU_593	COG0735	belongs to the Fur family
SMU_596	COG0588	phosphoglycerate mutase activity
SMU_597	COG0768	penicillin binding
SMU_598	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SMU_599	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMU_602	COG0385	Bile acid
SMU_603	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SMU_608	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SMU_610	COG3064	Membrane
SMU_610	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SMU_611	COG0513	Belongs to the DEAD box helicase family
SMU_621c	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SMU_623c	COG0726	polysaccharide deacetylase
SMU_624	COG0204	Acyl-transferase
SMU_625	COG1555	photosystem II stabilization
SMU_625	COG1596	polysaccharide export
SMU_626	COG0658	competence protein
SMU_626	COG2333	competence protein COMEC
SMU_629	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SMU_634	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SMU_636	COG0363	glucosamine-6-phosphate deaminase activity
SMU_638	COG1187	pseudouridine synthase activity
SMU_64	COG2255	four-way junction helicase activity
SMU_640c	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMU_641	COG0604	alcohol dehydrogenase
SMU_641	COG3321	synthase
SMU_641	COG1028	Short-chain dehydrogenase reductase Sdr
SMU_646	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SMU_646	COG0131	Imidazoleglycerol-phosphate dehydratase
SMU_647	COG4122	O-methyltransferase activity
SMU_648	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMU_65	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMU_650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMU_654	COG1131	(ABC) transporter
SMU_663	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SMU_664	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SMU_665	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SMU_666	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMU_668c	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMU_669c	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SMU_670	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SMU_671	COG0372	Belongs to the citrate synthase family
SMU_672	COG0538	isocitrate dehydrogenase activity
SMU_674	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMU_675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMU_676	COG1012	belongs to the aldehyde dehydrogenase family
SMU_677	COG0789	Transcriptional regulator
SMU_678	COG0656	L-ascorbic acid biosynthetic process
SMU_679	COG0656	L-ascorbic acid biosynthetic process
SMU_682	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SMU_691	COG2195	Cleaves the N-terminal amino acid of tripeptides
SMU_696	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SMU_697	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SMU_698	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SMU_699	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SMU_700c	COG0588	phosphoglycerate mutase activity
SMU_702c	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SMU_706c	COG3859	Proton-coupled thiamine transporter YuaJ
SMU_71	COG0534	Mate efflux family protein
SMU_712	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SMU_713	COG0772	Belongs to the SEDS family
SMU_714	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMU_715	COG0149	triose-phosphate isomerase activity
SMU_719c	COG1078	dGTPase activity
SMU_72	COG3830	Belongs to the UPF0237 family
SMU_724	COG0584	glycerophosphoryl diester phosphodiesterase
SMU_728	COG0604	alcohol dehydrogenase
SMU_73	COG2848	UPF0210 protein
SMU_742	COG0561	phosphatase activity
SMU_743	COG0561	phosphatase activity
SMU_744	COG0552	protein localization to endoplasmic reticulum
SMU_745	COG0477	Major facilitator Superfamily
SMU_746c	COG3689	TIGRFAM TIGR03943 family protein
SMU_747c	COG0701	Predicted permease
SMU_751	COG2183	response to ionizing radiation
SMU_752	COG3091	SprT-like family
SMU_754	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SMU_755	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SMU_76	COG1705	Flagellar rod assembly protein muramidase FlgJ
SMU_761	COG0826	peptidase U32
SMU_764	COG0450	alkyl hydroperoxide reductase
SMU_767	COG2801	Transposase and inactivated derivatives
SMU_769	COG4443	Transcriptional Coactivator p15 (PC4)
SMU_770c	COG1914	H( )-stimulated, divalent metal cation uptake system
SMU_772	COG0366	Alpha amylase catalytic
SMU_772	COG5263	repeat protein
SMU_773c	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SMU_775c	COG1368	sulfuric ester hydrolase activity
SMU_776	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SMU_777	COG0710	3-dehydroquinate dehydratase activity
SMU_778	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SMU_779	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SMU_78	COG5492	domain, Protein
SMU_78	COG3583	domain protein
SMU_78	COG1621	beta-fructofuranosidase activity
SMU_780	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SMU_781	COG0287	Prephenate dehydrogenase
SMU_782	COG3679	Belongs to the UPF0342 family
SMU_784	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SMU_785	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SMU_786	COG0077	Prephenate dehydratase
SMU_788	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMU_790	COG3620	sequence-specific DNA binding
SMU_80	COG1420	regulation of RNA biosynthetic process
SMU_801	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SMU_803c	COG0488	(ABC) transporter
SMU_805c	COG1126	abc transporter atp-binding protein
SMU_809	COG0556	nucleotide-excision repair
SMU_81	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SMU_814	COG1051	belongs to the nudix hydrolase family
SMU_815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMU_817	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMU_819	COG1970	mechanosensitive ion channel activity
SMU_82	COG0443	Heat shock 70 kDa protein
SMU_821	COG0358	DNA primase activity
SMU_822	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMU_823	COG2151	metal-sulfur cluster biosynthetic enzyme
SMU_824	COG1091	dTDP-4-dehydrorhamnose reductase activity
SMU_83	COG0484	heat shock protein binding
SMU_831	COG1368	sulfuric ester hydrolase activity
SMU_833	COG0463	Glycosyl transferase, family 2
SMU_836	COG3942	CHAP domain
SMU_837	COG0656	L-ascorbic acid biosynthetic process
SMU_838	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMU_839	COG0285	dihydrofolate synthase activity
SMU_84	COG0101	tRNA pseudouridine synthase activity
SMU_841	COG1104	cysteine desulfurase activity
SMU_842	COG0301	tRNA thio-modification
SMU_846	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SMU_849	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SMU_85	COG0351	phosphomethylpyrimidine kinase
SMU_851	COG2816	NAD+ diphosphatase activity
SMU_852	COG0583	DNA-binding transcription factor activity
SMU_853	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SMU_854	COG0564	pseudouridine synthase activity
SMU_856	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SMU_858	COG0540	Belongs to the ATCase OTCase family
SMU_859	COG0505	Belongs to the CarA family
SMU_86	COG4720	Psort location CytoplasmicMembrane, score
SMU_860	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SMU_863	COG1136	(ABC) transporter
SMU_864	COG0577	efflux transmembrane transporter activity
SMU_865	COG0228	four-way junction DNA binding
SMU_866	COG1837	Belongs to the UPF0109 family
SMU_867	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SMU_868	COG0336	Belongs to the RNA methyltransferase TrmD family
SMU_869	COG0492	ferredoxin-NADP+ reductase activity
SMU_87	COG4475	Protein of unknown function (DUF436)
SMU_870	COG1349	DNA-binding transcription factor activity
SMU_871	COG1105	Belongs to the carbohydrate kinase PfkB family
SMU_872	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMU_872	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMU_872	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMU_873	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SMU_874	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SMU_874	COG0646	methionine synthase
SMU_876	COG2207	Transcriptional regulator
SMU_877	COG3345	alpha-galactosidase
SMU_878	COG1653	transport
SMU_879	COG1175	transmembrane transport
SMU_880	COG0395	ABC-type sugar transport system, permease component
SMU_881	COG0366	Alpha amylase catalytic
SMU_882	COG3842	ATPase activity
SMU_883	COG0366	Alpha amylase catalytic
SMU_885	COG1609	Transcriptional regulator
SMU_886	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SMU_887	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SMU_888	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SMU_88c	COG0668	transmembrane transport
SMU_899	COG1307	EDD domain protein, DegV family
SMU_900	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SMU_901	COG0617	tRNA 3'-terminal CCA addition
SMU_902	COG0488	(ABC) transporter
SMU_906	COG1132	(ABC) transporter
SMU_91	COG0544	peptidyl-prolyl cis-trans isomerase activity
SMU_910	COG5263	repeat protein
SMU_910	COG0366	Alpha amylase catalytic
SMU_913	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SMU_915c	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SMU_916c	COG0602	queuosine metabolic process
SMU_919c	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SMU_923	COG1132	(ABC) transporter
SMU_924	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SMU_926	COG2357	RelA SpoT domain protein
SMU_927	COG0745	RESPONSE REGULATOR receiver
SMU_929c	COG3759	membrane
SMU_930c	COG0583	DNA-binding transcription factor activity
SMU_933	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMU_934	COG0765	amino acid transport
SMU_935	COG0765	amino acid transport
SMU_936	COG1126	abc transporter atp-binding protein
SMU_939	COG1304	FMN binding
SMU_940c	COG1272	protein, Hemolysin III
SMU_943c	COG3425	synthase
SMU_944	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SMU_946	COG3201	nicotinamide mononucleotide transporter
SMU_947	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SMU_949	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SMU_950	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SMU_951	COG0833	amino acid
SMU_952	COG2040	homocysteine
SMU_953c	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMU_957	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SMU_96	COG3343	RNA polymerase activity
SMU_960	COG0222	ribosome binding
SMU_962	COG1960	acyl-CoA dehydrogenase activity
SMU_963c	COG0726	polysaccharide deacetylase
SMU_966	COG0083	homoserine kinase activity
SMU_967	COG0285	dihydrofolate synthase activity
SMU_968	COG0302	gtp cyclohydrolase
SMU_97	COG0504	CTP synthase activity
SMU_972	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SMU_973	COG3842	ATPase activity
SMU_974	COG1176	ABC-type spermidine putrescine transport system, permease component I
SMU_975	COG1177	transmembrane transport
SMU_976	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SMU_977	COG3711	transcriptional antiterminator
SMU_980	COG2190	(PTS) system
SMU_980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMU_980	COG1263	PTS System
SMU_987	COG4932	domain protein
SMU_988	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SMU_989	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SMU_99	COG0191	fructose-bisphosphate aldolase activity
SMU_990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMU_993	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SMU_994	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SMU_995	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMU_996	COG4605	iron ion homeostasis
SMU_997	COG4604	ABC transporter, ATP-binding protein
SMU_998	COG4607	ABC-type enterochelin transport system periplasmic component