locus-tag	class	description
I6H78_RS00005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6H78_RS00015	COG0719	Fe-S assembly protein
I6H78_RS00025	COG0531	amino acid
I6H78_RS00030	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H78_RS00035	COG1307	EDD domain protein, DegV family
I6H78_RS00045	COG0039	L-malate dehydrogenase activity
I6H78_RS00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6H78_RS00055	COG3764	Sortase (surface protein transpeptidase)
I6H78_RS00080	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6H78_RS00105	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6H78_RS00110	COG1438	arginine binding
I6H78_RS00115	COG0497	DNA recombination
I6H78_RS00120	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6H78_RS00135	COG0758	DNA mediated transformation
I6H78_RS00140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6H78_RS00145	COG2832	Protein of unknown function (DUF454)
I6H78_RS00150	COG3142	Participates in the control of copper homeostasis
I6H78_RS00165	COG0473	3-isopropylmalate dehydrogenase activity
I6H78_RS00180	COG0066	3-isopropylmalate dehydratase activity
I6H78_RS00190	COG0516	GMP reductase activity
I6H78_RS00205	COG1196	nuclear chromosome segregation
I6H78_RS00210	COG0196	riboflavin kinase activity
I6H78_RS00215	COG3541	Predicted nucleotidyltransferase
I6H78_RS00230	COG3689	TIGRFAM TIGR03943 family protein
I6H78_RS00235	COG0701	Predicted permease
I6H78_RS00240	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6H78_RS00245	COG3421	Type III restriction
I6H78_RS00255	COG2183	response to ionizing radiation
I6H78_RS00270	COG1136	(ABC) transporter
I6H78_RS00275	COG0577	efflux transmembrane transporter activity
I6H78_RS00285	COG0561	phosphatase activity
I6H78_RS00290	COG0561	phosphatase activity
I6H78_RS00295	COG0552	protein localization to endoplasmic reticulum
I6H78_RS00300	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6H78_RS00305	COG1126	abc transporter atp-binding protein
I6H78_RS00310	COG0765	amino acid transport
I6H78_RS00355	COG1827	regulation of RNA biosynthetic process
I6H78_RS00370	COG4684	Psort location CytoplasmicMembrane, score
I6H78_RS00375	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6H78_RS00380	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6H78_RS00405	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6H78_RS00425	COG1104	cysteine desulfurase activity
I6H78_RS00430	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6H78_RS00440	COG2357	RelA SpoT domain protein
I6H78_RS00450	COG0564	pseudouridine synthase activity
I6H78_RS00455	COG0280	phosphate acetyltransferase
I6H78_RS00460	COG1194	a g-specific adenine glycosylase
I6H78_RS00465	COG0745	RESPONSE REGULATOR receiver
I6H78_RS00475	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6H78_RS00485	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H78_RS00495	COG0488	(ABC) transporter
I6H78_RS00505	COG2814	Major facilitator Superfamily
I6H78_RS00515	COG1523	belongs to the glycosyl hydrolase 13 family
I6H78_RS00520	COG1012	belongs to the aldehyde dehydrogenase family
I6H78_RS00525	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6H78_RS00535	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6H78_RS00545	COG0560	Phosphoserine phosphatase
I6H78_RS00570	COG2207	Transcriptional regulator
I6H78_RS00570	COG3708	Transcriptional regulator
I6H78_RS00600	COG1011	Hydrolase
I6H78_RS00615	COG1051	belongs to the nudix hydrolase family
I6H78_RS00620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6H78_RS00625	COG0534	Mate efflux family protein
I6H78_RS00630	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6H78_RS00635	COG0022	dehydrogenase e1 component
I6H78_RS00640	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H78_RS00645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H78_RS00650	COG0095	Lipoate-protein ligase
I6H78_RS00670	COG0038	chloride channel
I6H78_RS00680	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6H78_RS00710	COG1673	EVE domain
I6H78_RS00720	COG0561	phosphatase activity
I6H78_RS00730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6H78_RS00750	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6H78_RS00755	COG1982	Orn Lys Arg decarboxylase major
I6H78_RS00780	COG0366	Alpha amylase catalytic
I6H78_RS00785	COG0135	phosphoribosylanthranilate isomerase activity
I6H78_RS00790	COG1597	lipid kinase activity
I6H78_RS00925	COG1674	ftsk spoiiie
I6H78_RS00930	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6H78_RS00950	COG4842	Belongs to the WXG100 family
I6H78_RS00955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H78_RS00965	COG0741	lytic transglycosylase activity
I6H78_RS00990	COG2890	protein-(glutamine-N5) methyltransferase activity
I6H78_RS01005	COG1435	thymidine kinase activity
I6H78_RS01010	COG1942	4-Oxalocrotonate Tautomerase
I6H78_RS01015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6H78_RS01025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6H78_RS01035	COG4708	membrane
I6H78_RS01040	COG2246	polysaccharide biosynthetic process
I6H78_RS01045	COG1970	mechanosensitive ion channel activity
I6H78_RS01060	COG4509	Sortase family
I6H78_RS01070	COG0681	Belongs to the peptidase S26 family
I6H78_RS01080	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6H78_RS01100	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6H78_RS01100	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6H78_RS01125	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6H78_RS01130	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H78_RS01135	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H78_RS01145	COG2723	6-phospho-beta-galactosidase activity
I6H78_RS01160	COG3711	transcriptional antiterminator
I6H78_RS01165	COG3684	Belongs to the aldolase LacD family
I6H78_RS01190	COG3775	system Galactitol-specific IIC component
I6H78_RS01205	COG4750	Nucleotidyl transferase
I6H78_RS01220	COG1063	alcohol dehydrogenase
I6H78_RS01235	COG0584	glycerophosphoryl diester phosphodiesterase
I6H78_RS01240	COG2176	DNA-directed DNA polymerase activity
I6H78_RS01260	COG0494	nUDIX hydrolase
I6H78_RS01265	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6H78_RS01280	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6H78_RS01300	COG1126	abc transporter atp-binding protein
I6H78_RS01320	COG0628	permease
I6H78_RS01325	COG2706	6-phosphogluconolactonase activity
I6H78_RS01375	COG0826	peptidase U32
I6H78_RS01380	COG2188	Transcriptional regulator
I6H78_RS01390	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6H78_RS01405	COG0628	permease
I6H78_RS01410	COG1686	Belongs to the peptidase S11 family
I6H78_RS01415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H78_RS01420	COG0785	Cytochrome C biogenesis protein
I6H78_RS01425	COG0024	Methionine aminopeptidase
I6H78_RS01430	COG4109	DRTGG domain
I6H78_RS01440	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6H78_RS01445	COG0469	pyruvate kinase activity
I6H78_RS01460	COG2936	dipeptidyl-peptidase activity
I6H78_RS01465	COG1438	arginine binding
I6H78_RS01490	COG0438	transferase activity, transferring glycosyl groups
I6H78_RS01495	COG0438	transferase activity, transferring glycosyl groups
I6H78_RS01500	COG2151	metal-sulfur cluster biosynthetic enzyme
I6H78_RS01505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6H78_RS01510	COG0358	DNA primase activity
I6H78_RS01515	COG1116	anion transmembrane transporter activity
I6H78_RS01515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6H78_RS01530	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6H78_RS01535	COG0772	Belongs to the SEDS family
I6H78_RS01545	COG4122	O-methyltransferase activity
I6H78_RS01565	COG3615	Tellurite resistance protein tehB
I6H78_RS01565	COG0500	methyltransferase
I6H78_RS01575	COG0557	exoribonuclease II activity
I6H78_RS01585	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6H78_RS01590	COG2814	Major facilitator Superfamily
I6H78_RS01595	COG0237	dephospho-CoA kinase activity
I6H78_RS01600	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6H78_RS01610	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6H78_RS01620	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I6H78_RS01625	COG0813	purine-nucleoside phosphorylase activity
I6H78_RS01640	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6H78_RS01665	COG1136	(ABC) transporter
I6H78_RS01680	COG5002	protein histidine kinase activity
I6H78_RS01685	COG0745	RESPONSE REGULATOR receiver
I6H78_RS01710	COG1028	Short-chain dehydrogenase reductase Sdr
I6H78_RS01720	COG4989	oxidoreductase activity
I6H78_RS01730	COG4193	domain, Protein
I6H78_RS01730	COG5263	repeat protein
I6H78_RS01730	COG4193	domain, Protein
I6H78_RS01730	COG5263	repeat protein
I6H78_RS01735	COG0167	dihydroorotate dehydrogenase activity
I6H78_RS01740	COG0543	2 iron, 2 sulfur cluster binding
I6H78_RS01755	COG0443	Heat shock 70 kDa protein
I6H78_RS01760	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6H78_RS01765	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6H78_RS01780	COG1131	(ABC) transporter
I6H78_RS01790	COG0658	competence protein
I6H78_RS01790	COG2333	competence protein COMEC
I6H78_RS01795	COG1555	photosystem II stabilization
I6H78_RS01795	COG1596	polysaccharide export
I6H78_RS01805	COG0686	Belongs to the AlaDH PNT family
I6H78_RS01815	COG1702	phosphate starvation-inducible protein PhoH
I6H78_RS01825	COG0456	acetyltransferase
I6H78_RS01825	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6H78_RS01830	COG2996	Protein conserved in bacteria
I6H78_RS01840	COG0528	UMP kinase activity
I6H78_RS01860	COG0470	DNA polymerase III
I6H78_RS01870	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6H78_RS01885	COG0564	pseudouridine synthase activity
I6H78_RS01890	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6H78_RS01895	COG0583	DNA-binding transcription factor activity
I6H78_RS01925	COG0513	Belongs to the DEAD box helicase family
I6H78_RS01935	COG1078	dGTPase activity
I6H78_RS01970	COG1518	maintenance of DNA repeat elements
I6H78_RS01990	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6H78_RS01995	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6H78_RS02000	COG1605	Chorismate mutase
I6H78_RS02000	COG0077	Prephenate dehydratase
I6H78_RS02005	COG0716	FMN binding
I6H78_RS02010	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6H78_RS02025	COG1914	H( )-stimulated, divalent metal cation uptake system
I6H78_RS02035	COG0505	Belongs to the CarA family
I6H78_RS02050	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6H78_RS02065	COG0488	(ABC) transporter
I6H78_RS02070	COG1266	CAAX protease self-immunity
I6H78_RS02080	COG1704	LemA family
I6H78_RS02095	COG0697	spore germination
I6H78_RS02100	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6H78_RS02110	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H78_RS02135	COG1104	cysteine desulfurase activity
I6H78_RS02145	COG1136	(ABC) transporter
I6H78_RS02155	COG0697	spore germination
I6H78_RS02155	COG1674	ftsk spoiiie
I6H78_RS02160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H78_RS02160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H78_RS02160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H78_RS02165	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H78_RS02170	COG1349	DNA-binding transcription factor activity
I6H78_RS02200	COG0561	phosphatase activity
I6H78_RS02220	COG0492	ferredoxin-NADP+ reductase activity
I6H78_RS02230	COG1126	abc transporter atp-binding protein
I6H78_RS02240	COG1393	Belongs to the ArsC family
I6H78_RS02245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6H78_RS02260	COG1272	protein, Hemolysin III
I6H78_RS02265	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6H78_RS02290	COG3976	FMN-binding domain protein
I6H78_RS02290	COG0431	NADPH-dependent FMN reductase
I6H78_RS02290	COG1053	succinate dehydrogenase
I6H78_RS02320	COG0656	L-ascorbic acid biosynthetic process
I6H78_RS02325	COG0726	polysaccharide deacetylase
I6H78_RS02335	COG0187	DNA topoisomerase II activity
I6H78_RS02345	COG0366	Alpha amylase catalytic
I6H78_RS02345	COG5263	repeat protein
I6H78_RS02350	COG1396	sequence-specific DNA binding
I6H78_RS02355	COG0693	protein deglycase activity
I6H78_RS02360	COG0772	Belongs to the SEDS family
I6H78_RS02365	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6H78_RS02365	COG1199	ATP-dependent helicase activity
I6H78_RS02370	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6H78_RS02380	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6H78_RS02390	COG1126	abc transporter atp-binding protein
I6H78_RS02395	COG0765	amino acid transport
I6H78_RS02400	COG4703	Protein of unknown function (DUF1797)
I6H78_RS02405	COG0542	response to heat
I6H78_RS02415	COG2378	regulation of single-species biofilm formation
I6H78_RS02435	COG0513	Belongs to the DEAD box helicase family
I6H78_RS02445	COG2190	(PTS) system
I6H78_RS02445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H78_RS02445	COG1263	PTS System
I6H78_RS02450	COG2177	Part of the ABC transporter FtsEX involved in
I6H78_RS02455	COG2884	Cell division ATP-binding protein ftsE
I6H78_RS02465	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6H78_RS02465	COG0617	tRNA 3'-terminal CCA addition
I6H78_RS02465	COG0517	IMP dehydrogenase activity
I6H78_RS02500	COG0740	serine-type endopeptidase activity
I6H78_RS02505	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6H78_RS02510	COG2131	deaminase
I6H78_RS02520	COG1307	EDD domain protein, DegV family
I6H78_RS02525	COG2081	HI0933 family
I6H78_RS02540	COG0789	Transcriptional regulator
I6H78_RS02545	COG0733	neurotransmitter:sodium symporter activity
I6H78_RS02550	COG1482	cell wall glycoprotein biosynthetic process
I6H78_RS02565	COG0028	Belongs to the TPP enzyme family
I6H78_RS02570	COG2217	Heavy metal translocating P-type atpase
I6H78_RS02590	COG0352	thiamine-phosphate diphosphorylase activity
I6H78_RS02605	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6H78_RS02615	COG4172	Belongs to the ABC transporter superfamily
I6H78_RS02625	COG1304	FMN binding
I6H78_RS02640	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6H78_RS02660	COG1217	gtp-binding protein TYPA
I6H78_RS02665	COG1187	pseudouridine synthase activity
I6H78_RS02685	COG0583	DNA-binding transcription factor activity
I6H78_RS02690	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6H78_RS02690	COG2247	cell wall binding repeat
I6H78_RS02715	COG4555	ABC transporter
I6H78_RS02725	COG1733	regulation of RNA biosynthetic process
I6H78_RS02740	COG0191	fructose-bisphosphate aldolase activity
I6H78_RS02745	COG5002	protein histidine kinase activity
I6H78_RS02750	COG0745	RESPONSE REGULATOR receiver
I6H78_RS02755	COG0577	efflux transmembrane transporter activity
I6H78_RS02760	COG1136	(ABC) transporter
I6H78_RS02765	COG0577	efflux transmembrane transporter activity
I6H78_RS02780	COG1335	isochorismatase
I6H78_RS02785	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6H78_RS02790	COG0513	Belongs to the DEAD box helicase family
I6H78_RS02795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H78_RS02805	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H78_RS02810	COG3442	glutamine amidotransferase
I6H78_RS02815	COG0006	proline dipeptidase activity
I6H78_RS02820	COG4720	Psort location CytoplasmicMembrane, score
I6H78_RS02825	COG0351	phosphomethylpyrimidine kinase
I6H78_RS02845	COG2824	Alkylphosphonate utilization operon protein PhnA
I6H78_RS02855	COG0149	triose-phosphate isomerase activity
I6H78_RS02860	COG3935	DnaD domain protein
I6H78_RS02870	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6H78_RS02895	COG1363	Peptidase, m42
I6H78_RS02900	COG4808	Protein conserved in bacteria
I6H78_RS02910	COG1114	Component of the transport system for branched-chain amino acids
I6H78_RS02920	COG1573	uracil-dna glycosylase
I6H78_RS02945	COG0322	excinuclease ABC activity
I6H78_RS02950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H78_RS02950	COG5549	protein import
I6H78_RS02965	COG3942	CHAP domain
I6H78_RS02970	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6H78_RS02970	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6H78_RS02980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H78_RS02985	COG0765	amino acid transport
I6H78_RS02990	COG0765	amino acid transport
I6H78_RS03005	COG1959	2 iron, 2 sulfur cluster binding
I6H78_RS03025	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6H78_RS03040	COG0745	RESPONSE REGULATOR receiver
I6H78_RS03060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6H78_RS03070	COG3590	peptidase
I6H78_RS03090	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6H78_RS03110	COG0737	Belongs to the 5'-nucleotidase family
I6H78_RS03115	COG3842	ATPase activity
I6H78_RS03125	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6H78_RS03130	COG0215	cysteine-tRNA ligase activity
I6H78_RS03150	COG1045	serine acetyltransferase
I6H78_RS03165	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6H78_RS03200	COG1940	carbohydrate kinase activity
I6H78_RS03205	COG2190	(PTS) system
I6H78_RS03205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H78_RS03205	COG1263	PTS System
I6H78_RS03210	COG1621	beta-fructofuranosidase activity
I6H78_RS03215	COG1609	Transcriptional regulator
I6H78_RS03230	COG1857	crispr-associated protein
I6H78_RS03255	COG3425	synthase
I6H78_RS03270	COG0515	serine threonine protein kinase
I6H78_RS03270	COG2815	serine threonine protein kinase
I6H78_RS03275	COG0631	protein serine/threonine phosphatase activity
I6H78_RS03280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H78_RS03280	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6H78_RS03290	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6H78_RS03300	COG0194	GDP metabolic process
I6H78_RS03310	COG4115	mRNA cleavage
I6H78_RS03325	COG2226	methyltransferase
I6H78_RS03330	COG0799	negative regulation of ribosome biogenesis
I6H78_RS03340	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6H78_RS03345	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6H78_RS03350	COG1534	Rna-binding protein
I6H78_RS03355	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6H78_RS03360	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6H78_RS03370	COG0668	transmembrane transport
I6H78_RS03375	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6H78_RS03410	COG0438	transferase activity, transferring glycosyl groups
I6H78_RS03415	COG0438	transferase activity, transferring glycosyl groups
I6H78_RS03420	COG0653	protein targeting
I6H78_RS03445	COG1442	glycosyl transferase family 8
I6H78_RS03450	COG1442	glycosyl transferase family 8
I6H78_RS03460	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6H78_RS03525	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6H78_RS03530	COG0439	Biotin carboxylase
I6H78_RS03545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6H78_RS03550	COG1028	Short-chain dehydrogenase reductase Sdr
I6H78_RS03555	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6H78_RS03565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H78_RS03575	COG1846	Transcriptional regulator
I6H78_RS03580	COG1024	Enoyl-CoA hydratase
I6H78_RS03585	COG0527	aspartate kinase activity
I6H78_RS03615	COG1115	amino acid carrier protein
I6H78_RS03640	COG0681	Belongs to the peptidase S26 family
I6H78_RS03645	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6H78_RS03650	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6H78_RS03660	COG2197	response regulator
I6H78_RS03690	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6H78_RS03700	COG0745	RESPONSE REGULATOR receiver
I6H78_RS03705	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6H78_RS03715	COG0116	Belongs to the methyltransferase superfamily
I6H78_RS03750	COG0366	Alpha amylase catalytic
I6H78_RS03755	COG4166	transmembrane transport
I6H78_RS03760	COG3594	Acyltransferase
I6H78_RS03765	COG1442	glycosyl transferase family 8
I6H78_RS03765	COG1216	Glycosyl transferase, family 2
I6H78_RS03770	COG0438	transferase activity, transferring glycosyl groups
I6H78_RS03780	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6H78_RS03785	COG0438	transferase activity, transferring glycosyl groups
I6H78_RS03790	COG3475	LICD family
I6H78_RS03805	COG0562	UDP-galactopyranose mutase
I6H78_RS03815	COG0489	protein tyrosine kinase activity
I6H78_RS03820	COG3944	biosynthesis protein
I6H78_RS03825	COG4464	protein tyrosine phosphatase activity
I6H78_RS03835	COG4166	transmembrane transport
I6H78_RS03840	COG4166	transmembrane transport
I6H78_RS03865	COG0281	malic enzyme
I6H78_RS03875	COG0583	DNA-binding transcription factor activity
I6H78_RS03885	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6H78_RS03890	COG1668	transmembrane transport
I6H78_RS03895	COG4152	abc transporter atp-binding protein
I6H78_RS03900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H78_RS03900	COG0072	phenylalanine-tRNA ligase activity
I6H78_RS03915	COG0671	phosphoesterase, PA-phosphatase related
I6H78_RS03920	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I6H78_RS03930	COG0569	domain protein
I6H78_RS03935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6H78_RS03940	COG4608	Belongs to the ABC transporter superfamily
I6H78_RS03945	COG0444	Belongs to the ABC transporter superfamily
I6H78_RS03950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H78_RS03955	COG0601	transmembrane transport
I6H78_RS03960	COG4166	transmembrane transport
I6H78_RS03970	COG1253	flavin adenine dinucleotide binding
I6H78_RS03985	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6H78_RS03995	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6H78_RS04005	COG0742	ribosomal rna small subunit methyltransferase
I6H78_RS04020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H78_RS04025	COG1254	Belongs to the acylphosphatase family
I6H78_RS04035	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6H78_RS04045	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6H78_RS04050	COG3481	metal-dependent phosphohydrolase, HD sub domain
I6H78_RS04060	COG1564	THIamine pyrophosphokinase
I6H78_RS04070	COG1162	GTPase activity
I6H78_RS04095	COG0084	hydrolase, TatD family'
I6H78_RS04100	COG0531	amino acid
I6H78_RS04110	COG0436	Aminotransferase
I6H78_RS04120	COG0589	response to stress
I6H78_RS04125	COG0561	phosphatase activity
I6H78_RS04130	COG0252	asparaginase activity
I6H78_RS04135	COG1609	Transcriptional regulator
I6H78_RS04150	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6H78_RS04150	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6H78_RS04160	COG0285	dihydrofolate synthase activity
I6H78_RS04165	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6H78_RS04175	COG2252	PERMEase
I6H78_RS04180	COG0561	phosphatase activity
I6H78_RS04190	COG3715	PTS system
I6H78_RS04195	COG3716	PTS system mannose fructose sorbose family IID component
I6H78_RS04200	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6H78_RS04205	COG3579	cysteine-type endopeptidase activity
I6H78_RS04210	COG1187	pseudouridine synthase activity
I6H78_RS04215	COG2261	transglycosylase associated protein
I6H78_RS04220	COG2309	aminopeptidase activity
I6H78_RS04250	COG2176	DNA-directed DNA polymerase activity
I6H78_RS04340	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6H78_RS04345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H78_RS04405	COG1454	alcohol dehydrogenase
I6H78_RS04405	COG1012	belongs to the aldehyde dehydrogenase family
I6H78_RS04415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6H78_RS04420	COG1862	Preprotein translocase
I6H78_RS04425	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6H78_RS04435	COG1847	R3H domain protein
I6H78_RS04440	COG0706	membrane insertase activity
I6H78_RS04485	COG4537	Required for transformation and DNA binding
I6H78_RS04490	COG1459	type II secretion system
I6H78_RS04495	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6H78_RS04525	COG3759	membrane
I6H78_RS04540	COG0131	Imidazoleglycerol-phosphate dehydratase
I6H78_RS04540	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6H78_RS04545	COG0534	Mate efflux family protein
I6H78_RS04655	COG0166	Belongs to the GPI family
I6H78_RS04660	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6H78_RS04665	COG1132	(ABC) transporter
I6H78_RS04670	COG1132	(ABC) transporter
I6H78_RS04680	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6H78_RS04690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6H78_RS04705	COG0697	spore germination
I6H78_RS04710	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6H78_RS04710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H78_RS04720	COG2226	methyltransferase
I6H78_RS04725	COG0058	SHG alpha-glucan phosphorylase activity
I6H78_RS04730	COG1640	4-alpha-glucanotransferase
I6H78_RS04735	COG2182	Extracellular solute-binding protein
I6H78_RS04740	COG1175	transmembrane transport
I6H78_RS04745	COG3833	ABC-type maltose transport systems, permease component
I6H78_RS04750	COG5521	maltodextrose utilization protein MalA
I6H78_RS04755	COG1609	Transcriptional regulator
I6H78_RS04760	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H78_RS04780	COG0124	histidyl-tRNA synthetase
I6H78_RS04795	COG2151	metal-sulfur cluster biosynthetic enzyme
I6H78_RS04825	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6H78_RS04835	COG0515	serine threonine protein kinase
I6H78_RS04835	COG2815	serine threonine protein kinase
I6H78_RS04890	COG0582	viral genome integration into host DNA
I6H78_RS04910	COG0583	DNA-binding transcription factor activity
I6H78_RS04930	COG5002	protein histidine kinase activity
I6H78_RS04935	COG0745	RESPONSE REGULATOR receiver
I6H78_RS04950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6H78_RS04960	COG1309	transcriptional regulator
I6H78_RS04990	COG0110	maltose O-acetyltransferase activity
I6H78_RS04995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6H78_RS04995	COG0425	Belongs to the sulfur carrier protein TusA family
I6H78_RS05000	COG0425	Belongs to the sulfur carrier protein TusA family
I6H78_RS05000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6H78_RS05005	COG1937	Protein conserved in bacteria
I6H78_RS05035	COG2514	catechol 2,3-dioxygenase activity
I6H78_RS05045	COG3684	Belongs to the aldolase LacD family
I6H78_RS05050	COG2222	sugar isomerase
I6H78_RS05060	COG3716	PTS system mannose fructose sorbose family IID component
I6H78_RS05065	COG3715	PTS system
I6H78_RS05070	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H78_RS05085	COG3583	domain protein
I6H78_RS05085	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6H78_RS05085	COG3064	Membrane
I6H78_RS05090	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6H78_RS05105	COG1794	racemase activity, acting on amino acids and derivatives
I6H78_RS05125	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6H78_RS05130	COG0151	Belongs to the GarS family
I6H78_RS05145	COG0138	bifunctional purine biosynthesis protein purh
I6H78_RS05150	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6H78_RS05155	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6H78_RS05165	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6H78_RS05175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H78_RS05180	COG2274	protein secretion by the type I secretion system
I6H78_RS05205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H78_RS05220	COG0436	Aminotransferase
I6H78_RS05225	COG2855	membrane
I6H78_RS05230	COG1832	CoA-binding protein
I6H78_RS05235	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6H78_RS05245	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6H78_RS05255	COG0756	dUTP diphosphatase activity
I6H78_RS05310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6H78_RS05315	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6H78_RS05335	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6H78_RS05340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6H78_RS05350	COG0012	GTP binding
I6H78_RS05360	COG0592	DNA-directed DNA polymerase activity
I6H78_RS05370	COG1475	DNA binding
I6H78_RS05375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H78_RS05420	COG1511	domain protein
I6H78_RS05420	COG1511	domain protein
I6H78_RS05430	COG0488	(ABC) transporter
I6H78_RS05435	COG0180	Tryptophanyl-tRNA synthetase
I6H78_RS05440	COG0516	GMP reductase activity
I6H78_RS05440	COG0517	IMP dehydrogenase activity
I6H78_RS05450	COG2501	S4 domain
I6H78_RS05455	COG0612	Peptidase, M16
I6H78_RS05460	COG0612	Peptidase, M16
I6H78_RS05470	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6H78_RS05475	COG1122	ATPase activity
I6H78_RS05480	COG1122	ATPase activity
I6H78_RS05485	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6H78_RS05490	COG1792	Involved in formation and maintenance of cell shape
I6H78_RS05500	COG3942	CHAP domain
I6H78_RS05525	COG1739	Uncharacterized protein family UPF0029
I6H78_RS05530	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6H78_RS05535	COG1040	competence protein
I6H78_RS05555	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I6H78_RS05565	COG0305	Participates in initiation and elongation during chromosome replication
I6H78_RS05575	COG3942	CHAP domain
I6H78_RS05585	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H78_RS05585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H78_RS05595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H78_RS05600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6H78_RS05605	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6H78_RS05615	COG4463	regulation of RNA biosynthetic process
I6H78_RS05620	COG0542	response to heat
I6H78_RS05630	COG3201	nicotinamide mononucleotide transporter
I6H78_RS05645	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6H78_RS05665	COG1696	Membrane protein involved in D-alanine export
I6H78_RS05675	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6H78_RS05680	COG0737	Belongs to the 5'-nucleotidase family
I6H78_RS05685	COG1846	Transcriptional regulator
I6H78_RS05690	COG1121	(ABC) transporter
I6H78_RS05695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H78_RS05700	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6H78_RS05700	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6H78_RS05725	COG0383	alpha-mannosidase activity
I6H78_RS05745	COG4209	transmembrane transport
I6H78_RS05750	COG0395	ABC-type sugar transport system, permease component
I6H78_RS05755	COG1653	transport
I6H78_RS05805	COG2807	transmembrane transport
I6H78_RS05810	COG1216	Glycosyl transferase, family 2
I6H78_RS05820	COG0546	phosphoglycolate phosphatase activity
I6H78_RS05825	COG1760	l-serine dehydratase
I6H78_RS05830	COG1760	l-serine dehydratase
I6H78_RS05835	COG3584	3D domain protein
I6H78_RS05835	COG1388	LysM domain
I6H78_RS05840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H78_RS05845	COG0137	argininosuccinate synthase activity
I6H78_RS05860	COG0494	nUDIX hydrolase
I6H78_RS05865	COG0445	tRNA wobble uridine modification
I6H78_RS05910	COG1214	PFAM Peptidase M22, glycoprotease
I6H78_RS05925	COG1396	sequence-specific DNA binding
I6H78_RS05955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H78_RS05960	COG1464	Belongs to the NlpA lipoprotein family
I6H78_RS05965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H78_RS05970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6H78_RS05990	COG2972	Histidine kinase
I6H78_RS05995	COG2207	Transcriptional regulator
I6H78_RS05995	COG4753	response regulator
I6H78_RS06005	COG1780	Probably involved in ribonucleotide reductase function
I6H78_RS06025	COG1438	arginine binding
I6H78_RS06050	COG1395	domain, Protein
I6H78_RS06060	COG2818	Glycosylase
I6H78_RS06090	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6H78_RS06095	COG0006	proline dipeptidase activity
I6H78_RS06100	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6H78_RS06105	COG1393	Belongs to the ArsC family
I6H78_RS06130	COG0285	dihydrofolate synthase activity
I6H78_RS06140	COG1454	alcohol dehydrogenase
I6H78_RS06145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H78_RS06160	COG1328	CTP reductase activity
I6H78_RS06220	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6H78_RS06245	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6H78_RS06265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6H78_RS06285	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6H78_RS06300	COG0201	protein transport
I6H78_RS06310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6H78_RS06315	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6H78_RS06325	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6H78_RS06330	COG0202	RNA polymerase activity
I6H78_RS06340	COG3830	Belongs to the UPF0237 family
I6H78_RS06345	COG2848	UPF0210 protein
I6H78_RS06350	COG0588	phosphoglycerate mutase activity
I6H78_RS06390	COG3279	Response regulator of the LytR AlgR family
I6H78_RS06415	COG1940	carbohydrate kinase activity
I6H78_RS06420	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H78_RS06425	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6H78_RS06430	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H78_RS06440	COG4989	oxidoreductase activity
I6H78_RS06445	COG2255	four-way junction helicase activity
I6H78_RS06455	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6H78_RS06460	COG4589	Belongs to the CDS family
I6H78_RS06465	COG0750	zinc metalloprotease
I6H78_RS06475	COG2723	6-phospho-beta-galactosidase activity
I6H78_RS06485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6H78_RS06535	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I6H78_RS06555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H78_RS06560	COG0765	amino acid transport
I6H78_RS06565	COG0765	amino acid transport
I6H78_RS06570	COG1126	abc transporter atp-binding protein
I6H78_RS06575	COG1523	belongs to the glycosyl hydrolase 13 family
I6H78_RS06600	COG0802	atpase or kinase
I6H78_RS06610	COG1316	TRANSCRIPTIONal
I6H78_RS06635	COG0534	Mate efflux family protein
I6H78_RS06680	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6H78_RS06690	COG1461	Dihydroxyacetone kinase
I6H78_RS06710	COG1131	(ABC) transporter
I6H78_RS06720	COG4585	Histidine kinase
I6H78_RS06725	COG2197	response regulator
I6H78_RS06745	COG0028	Belongs to the TPP enzyme family
I6H78_RS06750	COG0440	acetolactate synthase activity
I6H78_RS06760	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6H78_RS06775	COG1126	abc transporter atp-binding protein
I6H78_RS06780	COG0765	amino acid transport
I6H78_RS06815	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6H78_RS06820	COG1882	Formate acetyltransferase
I6H78_RS06835	COG1131	(ABC) transporter
I6H78_RS06865	COG0366	Alpha amylase catalytic
I6H78_RS06870	COG0366	Alpha amylase catalytic
I6H78_RS06875	COG0386	Belongs to the glutathione peroxidase family
I6H78_RS06905	COG4839	cell division protein FtsL
I6H78_RS06910	COG0768	penicillin binding
I6H78_RS06920	COG0366	Alpha amylase catalytic
I6H78_RS06925	COG2188	Transcriptional regulator
I6H78_RS06930	COG1263	PTS System
I6H78_RS06930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H78_RS06935	COG0366	Alpha amylase catalytic
I6H78_RS06960	COG0517	IMP dehydrogenase activity
I6H78_RS06980	COG1187	pseudouridine synthase activity
I6H78_RS06990	COG4607	ABC-type enterochelin transport system periplasmic component
I6H78_RS06995	COG4604	ABC transporter, ATP-binding protein
I6H78_RS07000	COG4605	iron ion homeostasis
I6H78_RS07005	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H78_RS07010	COG1363	Peptidase, m42
I6H78_RS07035	COG2378	regulation of single-species biofilm formation
I6H78_RS07040	COG0126	phosphoglycerate kinase activity
I6H78_RS07055	COG0789	Transcriptional regulator
I6H78_RS07060	COG0174	glutamine synthetase
I6H78_RS07095	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6H78_RS07105	COG0484	heat shock protein binding
I6H78_RS07115	COG0537	adenosine 5'-monophosphoramidase activity
I6H78_RS07120	COG1131	(ABC) transporter
I6H78_RS07125	COG4473	ABC transporter
I6H78_RS07145	COG3290	protein histidine kinase activity
I6H78_RS07155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H78_RS07160	COG2274	protein secretion by the type I secretion system
I6H78_RS07225	COG1266	CAAX protease self-immunity
I6H78_RS07245	COG0195	Participates in both transcription termination and antitermination
I6H78_RS07250	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6H78_RS07310	COG0525	valine-tRNA ligase activity
I6H78_RS07325	COG0504	CTP synthase activity
I6H78_RS07335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H78_RS07340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H78_RS07345	COG4221	oxidoreductase activity
I6H78_RS07380	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H78_RS07500	COG2207	Transcriptional regulator
I6H78_RS07505	COG3345	alpha-galactosidase
I6H78_RS07510	COG1653	transport
I6H78_RS07515	COG1175	transmembrane transport
I6H78_RS07520	COG0395	ABC-type sugar transport system, permease component
I6H78_RS07525	COG0366	Alpha amylase catalytic
I6H78_RS07540	COG0517	IMP dehydrogenase activity
I6H78_RS07540	COG1125	glycine betaine transport
I6H78_RS07545	COG1174	glycine betaine transport
I6H78_RS07550	COG3201	nicotinamide mononucleotide transporter
I6H78_RS07570	COG1609	Transcriptional regulator
I6H78_RS07575	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6H78_RS07580	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I6H78_RS07590	COG2233	PERMEase
I6H78_RS07605	COG0708	Exodeoxyribonuclease III
I6H78_RS07615	COG2323	membrane
I6H78_RS07620	COG1132	(ABC) transporter
I6H78_RS07625	COG1132	(ABC) transporter
I6H78_RS07630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6H78_RS07640	COG0133	tryptophan synthase activity
I6H78_RS07645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6H78_RS07650	COG0512	Glutamine amidotransferase of anthranilate synthase
I6H78_RS07690	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6H78_RS07710	COG3237	CsbD-like
I6H78_RS07730	COG2261	transglycosylase associated protein
I6H78_RS07735	COG3711	transcriptional antiterminator
I6H78_RS07745	COG4209	transmembrane transport
I6H78_RS07750	COG0395	ABC-type sugar transport system, permease component
I6H78_RS07755	COG1653	transport
I6H78_RS07760	COG1621	beta-fructofuranosidase activity
I6H78_RS07770	COG0596	Alpha beta hydrolase
I6H78_RS07775	COG0604	alcohol dehydrogenase
I6H78_RS07775	COG3321	synthase
I6H78_RS07775	COG1028	Short-chain dehydrogenase reductase Sdr
I6H78_RS07790	COG1129	ABC transporter
I6H78_RS07810	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6H78_RS07825	COG1051	belongs to the nudix hydrolase family
I6H78_RS07835	COG2264	protein methyltransferase activity
I6H78_RS07840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6H78_RS07845	COG1164	Oligoendopeptidase f
I6H78_RS07855	COG1733	regulation of RNA biosynthetic process
I6H78_RS07860	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H78_RS07875	COG0720	synthase
I6H78_RS07885	COG3118	belongs to the thioredoxin family
I6H78_RS07905	COG1346	cytolysis
I6H78_RS07915	COG1131	(ABC) transporter
I6H78_RS07920	COG1725	Transcriptional regulator
I6H78_RS07935	COG1484	DNA-dependent DNA replication
I6H78_RS07940	COG0778	Nitroreductase
I6H78_RS07975	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6H78_RS07980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6H78_RS07995	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6H78_RS08000	COG3458	cephalosporin-C deacetylase activity
I6H78_RS08020	COG1175	transmembrane transport
I6H78_RS08025	COG0395	ABC-type sugar transport system, permease component
I6H78_RS08030	COG2731	YhcH YjgK YiaL family protein
I6H78_RS08050	COG2226	methyltransferase
I6H78_RS08060	COG0768	penicillin binding
I6H78_RS08075	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H78_RS08080	COG1051	belongs to the nudix hydrolase family
I6H78_RS08100	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6H78_RS08120	COG3599	regulation of cell shape
I6H78_RS08125	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6H78_RS08135	COG0588	phosphoglycerate mutase activity
I6H78_RS08145	COG2205	protein histidine kinase activity
I6H78_RS08150	COG0745	RESPONSE REGULATOR receiver
I6H78_RS08175	COG0577	efflux transmembrane transporter activity
I6H78_RS08175	COG1136	(ABC) transporter
I6H78_RS08195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H78_RS08215	COG0204	Acyl-transferase
I6H78_RS08220	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6H78_RS08225	COG2384	SAM-dependent methyltransferase
I6H78_RS08230	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6H78_RS08235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H78_RS08240	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6H78_RS08245	COG0463	Glycosyl transferase, family 2
I6H78_RS08265	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6H78_RS08280	COG0251	oxidation-reduction process
I6H78_RS08290	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6H78_RS08300	COG0492	ferredoxin-NADP+ reductase activity
I6H78_RS08335	COG0617	tRNA 3'-terminal CCA addition
I6H78_RS08340	COG0488	(ABC) transporter
I6H78_RS08350	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6H78_RS08365	COG0463	Glycosyl transferase, family 2
I6H78_RS08375	COG0242	peptide deformylase activity
I6H78_RS08395	COG1846	Transcriptional regulator
I6H78_RS08405	COG0436	Aminotransferase
I6H78_RS08410	COG0017	Asparaginyl-tRNA synthetase
I6H78_RS08420	COG0360	Binds together with S18 to 16S ribosomal RNA
I6H78_RS08425	COG0629	single-stranded DNA binding
I6H78_RS08430	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6H78_RS08440	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6H78_RS08450	COG1215	transferase activity, transferring glycosyl groups
I6H78_RS08455	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6H78_RS08465	COG1098	S1 RNA binding domain
I6H78_RS08470	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6H78_RS08475	COG2827	Endonuclease containing a URI domain
I6H78_RS08500	COG3237	CsbD-like
I6H78_RS08505	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6H78_RS08510	COG2244	polysaccharide biosynthetic process
I6H78_RS08515	COG4166	transmembrane transport
I6H78_RS08520	COG0626	cystathionine gamma-synthase activity
I6H78_RS08525	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6H78_RS08530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6H78_RS08555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6H78_RS08565	COG1113	amino acid transport
I6H78_RS08590	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6H78_RS08600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6H78_RS08605	COG0785	Cytochrome C biogenesis protein
I6H78_RS08615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H78_RS08615	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H78_RS08620	COG4753	response regulator
I6H78_RS08620	COG2207	Transcriptional regulator
I6H78_RS08625	COG2972	Histidine kinase
I6H78_RS08635	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6H78_RS08640	COG1940	carbohydrate kinase activity
I6H78_RS08660	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6H78_RS08680	COG0300	oxidoreductase activity
I6H78_RS08685	COG3250	beta-galactosidase activity
I6H78_RS08700	COG2226	methyltransferase
I6H78_RS08710	COG1242	4 iron, 4 sulfur cluster binding
I6H78_RS08715	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6H78_RS08725	COG0025	NhaP-type Na H and K H
I6H78_RS08745	COG4106	trans-aconitate 2-methyltransferase activity
I6H78_RS08760	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6H78_RS08785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6H78_RS08795	COG0647	UMP catabolic process
I6H78_RS08805	COG1393	Belongs to the ArsC family
I6H78_RS08815	COG0483	inositol monophosphate 1-phosphatase activity
I6H78_RS08820	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6H78_RS08820	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6H78_RS08825	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6H78_RS08830	COG0573	inorganic phosphate transmembrane transporter activity
I6H78_RS08835	COG0581	inorganic phosphate transmembrane transporter activity
I6H78_RS08840	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6H78_RS08845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6H78_RS08850	COG0704	Plays a role in the regulation of phosphate uptake
I6H78_RS08855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H78_RS08860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H78_RS08865	COG3527	Alpha-acetolactate decarboxylase
I6H78_RS08880	COG3842	ATPase activity
I6H78_RS08885	COG1177	transmembrane transport
I6H78_RS08905	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6H78_RS08915	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6H78_RS08940	COG0287	Prephenate dehydrogenase
I6H78_RS08945	COG3679	Belongs to the UPF0342 family
I6H78_RS08960	COG0077	Prephenate dehydratase
I6H78_RS08970	COG3475	LICD family
I6H78_RS08975	COG1216	Glycosyl transferase, family 2
I6H78_RS08975	COG1442	glycosyl transferase family 8
I6H78_RS08980	COG3475	LICD family
I6H78_RS09015	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H78_RS09015	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H78_RS09030	COG0402	S-adenosylhomocysteine deaminase activity
I6H78_RS09035	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6H78_RS09040	COG0222	ribosome binding
I6H78_RS09045	COG5504	Zn-dependent protease
I6H78_RS09060	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6H78_RS09065	COG0167	dihydroorotate dehydrogenase activity
I6H78_RS09075	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6H78_RS09080	COG4470	Protein conserved in bacteria
I6H78_RS09085	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6H78_RS09095	COG0488	(ABC) transporter
I6H78_RS09105	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6H78_RS09140	COG1328	CTP reductase activity
I6H78_RS09140	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6H78_RS09150	COG4443	Transcriptional Coactivator p15 (PC4)
I6H78_RS09165	COG1268	BioY protein
I6H78_RS09170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H78_RS09175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H78_RS09180	COG1136	(ABC) transporter
I6H78_RS09185	COG0577	efflux transmembrane transporter activity
I6H78_RS09190	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H78_RS09190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H78_RS09210	COG2813	Specifically methylates the guanine in position
I6H78_RS09215	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6H78_RS09225	COG0295	cytidine deaminase activity
I6H78_RS09230	COG1744	ABC transporter substrate-binding protein PnrA-like
I6H78_RS09235	COG3845	ABC transporter
I6H78_RS09240	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6H78_RS09245	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6H78_RS09255	COG0187	DNA topoisomerase II activity
I6H78_RS09265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6H78_RS09270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6H78_RS09290	COG0539	negative regulation of cytoplasmic translation
I6H78_RS09295	COG1956	GAF domain-containing protein
I6H78_RS09300	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6H78_RS09315	COG0719	Fe-S assembly protein