locus-tag	class	description
I6I32_RS00015	COG0066	3-isopropylmalate dehydratase activity
I6I32_RS00055	COG0571	ribonuclease III activity
I6I32_RS00060	COG1196	nuclear chromosome segregation
I6I32_RS00065	COG0196	riboflavin kinase activity
I6I32_RS00070	COG3541	Predicted nucleotidyltransferase
I6I32_RS00085	COG3689	TIGRFAM TIGR03943 family protein
I6I32_RS00090	COG0701	Predicted permease
I6I32_RS00095	COG2183	response to ionizing radiation
I6I32_RS00110	COG1136	(ABC) transporter
I6I32_RS00115	COG0577	efflux transmembrane transporter activity
I6I32_RS00125	COG0561	phosphatase activity
I6I32_RS00130	COG0561	phosphatase activity
I6I32_RS00135	COG0552	protein localization to endoplasmic reticulum
I6I32_RS00140	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6I32_RS00145	COG1126	abc transporter atp-binding protein
I6I32_RS00150	COG0765	amino acid transport
I6I32_RS00190	COG1827	regulation of RNA biosynthetic process
I6I32_RS00205	COG4684	Psort location CytoplasmicMembrane, score
I6I32_RS00210	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I32_RS00215	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I32_RS00240	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6I32_RS00260	COG1104	cysteine desulfurase activity
I6I32_RS00265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I32_RS00275	COG2357	RelA SpoT domain protein
I6I32_RS00285	COG0564	pseudouridine synthase activity
I6I32_RS00290	COG0280	phosphate acetyltransferase
I6I32_RS00295	COG1194	a g-specific adenine glycosylase
I6I32_RS00300	COG0745	RESPONSE REGULATOR receiver
I6I32_RS00310	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6I32_RS00315	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I32_RS00325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I32_RS00335	COG0488	(ABC) transporter
I6I32_RS00355	COG1523	belongs to the glycosyl hydrolase 13 family
I6I32_RS00360	COG1012	belongs to the aldehyde dehydrogenase family
I6I32_RS00365	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6I32_RS00375	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6I32_RS00385	COG0560	Phosphoserine phosphatase
I6I32_RS00410	COG3708	Transcriptional regulator
I6I32_RS00410	COG2207	Transcriptional regulator
I6I32_RS00435	COG1011	Hydrolase
I6I32_RS00455	COG1051	belongs to the nudix hydrolase family
I6I32_RS00460	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6I32_RS00465	COG0534	Mate efflux family protein
I6I32_RS00470	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6I32_RS00475	COG0022	dehydrogenase e1 component
I6I32_RS00480	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I32_RS00485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I32_RS00490	COG0095	Lipoate-protein ligase
I6I32_RS00515	COG0038	chloride channel
I6I32_RS00525	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6I32_RS00555	COG1673	EVE domain
I6I32_RS00565	COG0561	phosphatase activity
I6I32_RS00570	COG1131	(ABC) transporter
I6I32_RS00580	COG2205	protein histidine kinase activity
I6I32_RS00585	COG0745	RESPONSE REGULATOR receiver
I6I32_RS00595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I32_RS00615	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6I32_RS00620	COG1982	Orn Lys Arg decarboxylase major
I6I32_RS00655	COG1597	lipid kinase activity
I6I32_RS00795	COG5444	nuclease activity
I6I32_RS00855	COG1674	ftsk spoiiie
I6I32_RS00860	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6I32_RS00880	COG4842	Belongs to the WXG100 family
I6I32_RS00885	COG0135	phosphoribosylanthranilate isomerase activity
I6I32_RS00910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I32_RS00920	COG0741	lytic transglycosylase activity
I6I32_RS00945	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I32_RS00960	COG1435	thymidine kinase activity
I6I32_RS00965	COG1942	4-Oxalocrotonate Tautomerase
I6I32_RS00970	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6I32_RS00980	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I32_RS00990	COG4708	membrane
I6I32_RS00995	COG2246	polysaccharide biosynthetic process
I6I32_RS01000	COG1970	mechanosensitive ion channel activity
I6I32_RS01015	COG4509	Sortase family
I6I32_RS01025	COG0681	Belongs to the peptidase S26 family
I6I32_RS01045	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6I32_RS01045	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I32_RS01060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I32_RS01070	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I32_RS01075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I32_RS01080	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I32_RS01090	COG2723	6-phospho-beta-galactosidase activity
I6I32_RS01105	COG3711	transcriptional antiterminator
I6I32_RS01110	COG3684	Belongs to the aldolase LacD family
I6I32_RS01135	COG3775	system Galactitol-specific IIC component
I6I32_RS01150	COG4750	Nucleotidyl transferase
I6I32_RS01165	COG1063	alcohol dehydrogenase
I6I32_RS01180	COG0584	glycerophosphoryl diester phosphodiesterase
I6I32_RS01185	COG2176	DNA-directed DNA polymerase activity
I6I32_RS01205	COG0494	nUDIX hydrolase
I6I32_RS01210	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I32_RS01225	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I32_RS01245	COG1126	abc transporter atp-binding protein
I6I32_RS01265	COG0628	permease
I6I32_RS01270	COG2706	6-phosphogluconolactonase activity
I6I32_RS01320	COG0826	peptidase U32
I6I32_RS01325	COG2188	Transcriptional regulator
I6I32_RS01335	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I32_RS01350	COG0628	permease
I6I32_RS01355	COG1686	Belongs to the peptidase S11 family
I6I32_RS01360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I32_RS01365	COG0785	Cytochrome C biogenesis protein
I6I32_RS01370	COG0024	Methionine aminopeptidase
I6I32_RS01375	COG4109	DRTGG domain
I6I32_RS01385	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I32_RS01390	COG0469	pyruvate kinase activity
I6I32_RS01405	COG2936	dipeptidyl-peptidase activity
I6I32_RS01410	COG1438	arginine binding
I6I32_RS01435	COG0438	transferase activity, transferring glycosyl groups
I6I32_RS01440	COG0438	transferase activity, transferring glycosyl groups
I6I32_RS01445	COG2151	metal-sulfur cluster biosynthetic enzyme
I6I32_RS01450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6I32_RS01455	COG0358	DNA primase activity
I6I32_RS01475	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6I32_RS01480	COG0772	Belongs to the SEDS family
I6I32_RS01490	COG4122	O-methyltransferase activity
I6I32_RS01510	COG3615	Tellurite resistance protein tehB
I6I32_RS01510	COG0500	methyltransferase
I6I32_RS01520	COG0557	exoribonuclease II activity
I6I32_RS01530	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I32_RS01535	COG2814	Major facilitator Superfamily
I6I32_RS01540	COG0237	dephospho-CoA kinase activity
I6I32_RS01545	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I32_RS01555	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6I32_RS01565	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I6I32_RS01570	COG0813	purine-nucleoside phosphorylase activity
I6I32_RS01575	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6I32_RS01600	COG1136	(ABC) transporter
I6I32_RS01615	COG5002	protein histidine kinase activity
I6I32_RS01620	COG0745	RESPONSE REGULATOR receiver
I6I32_RS01670	COG1028	Short-chain dehydrogenase reductase Sdr
I6I32_RS01680	COG4989	oxidoreductase activity
I6I32_RS01690	COG5263	repeat protein
I6I32_RS01690	COG4193	domain, Protein
I6I32_RS01695	COG0167	dihydroorotate dehydrogenase activity
I6I32_RS01700	COG0543	2 iron, 2 sulfur cluster binding
I6I32_RS01715	COG0443	Heat shock 70 kDa protein
I6I32_RS01720	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6I32_RS01725	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6I32_RS01735	COG2333	competence protein COMEC
I6I32_RS01735	COG0658	competence protein
I6I32_RS01740	COG1555	photosystem II stabilization
I6I32_RS01740	COG1596	polysaccharide export
I6I32_RS01745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I32_RS01750	COG0686	Belongs to the AlaDH PNT family
I6I32_RS01755	COG1702	phosphate starvation-inducible protein PhoH
I6I32_RS01765	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6I32_RS01765	COG0456	acetyltransferase
I6I32_RS01770	COG2996	Protein conserved in bacteria
I6I32_RS01780	COG0528	UMP kinase activity
I6I32_RS01800	COG0470	DNA polymerase III
I6I32_RS01810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6I32_RS01825	COG0564	pseudouridine synthase activity
I6I32_RS01830	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I32_RS01835	COG0583	DNA-binding transcription factor activity
I6I32_RS01865	COG0513	Belongs to the DEAD box helicase family
I6I32_RS01875	COG1078	dGTPase activity
I6I32_RS01935	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I32_RS01940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I32_RS01945	COG0077	Prephenate dehydratase
I6I32_RS01945	COG1605	Chorismate mutase
I6I32_RS01950	COG0716	FMN binding
I6I32_RS01955	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6I32_RS01970	COG1914	H( )-stimulated, divalent metal cation uptake system
I6I32_RS01980	COG0505	Belongs to the CarA family
I6I32_RS01995	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I32_RS02010	COG0488	(ABC) transporter
I6I32_RS02020	COG1266	CAAX protease self-immunity
I6I32_RS02030	COG1704	LemA family
I6I32_RS02045	COG0697	spore germination
I6I32_RS02050	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I32_RS02060	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I32_RS02085	COG1104	cysteine desulfurase activity
I6I32_RS02095	COG1674	ftsk spoiiie
I6I32_RS02095	COG0697	spore germination
I6I32_RS02100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I32_RS02100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I32_RS02100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I32_RS02105	COG1105	Belongs to the carbohydrate kinase PfkB family
I6I32_RS02110	COG1349	DNA-binding transcription factor activity
I6I32_RS02140	COG0561	phosphatase activity
I6I32_RS02160	COG0492	ferredoxin-NADP+ reductase activity
I6I32_RS02170	COG1126	abc transporter atp-binding protein
I6I32_RS02180	COG1393	Belongs to the ArsC family
I6I32_RS02185	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I32_RS02200	COG1272	protein, Hemolysin III
I6I32_RS02230	COG3976	FMN-binding domain protein
I6I32_RS02230	COG1053	succinate dehydrogenase
I6I32_RS02230	COG0431	NADPH-dependent FMN reductase
I6I32_RS02255	COG0656	L-ascorbic acid biosynthetic process
I6I32_RS02260	COG0726	polysaccharide deacetylase
I6I32_RS02270	COG0187	DNA topoisomerase II activity
I6I32_RS02280	COG0366	Alpha amylase catalytic
I6I32_RS02280	COG5263	repeat protein
I6I32_RS02285	COG1396	sequence-specific DNA binding
I6I32_RS02290	COG0693	protein deglycase activity
I6I32_RS02295	COG0772	Belongs to the SEDS family
I6I32_RS02300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I32_RS02300	COG1199	ATP-dependent helicase activity
I6I32_RS02305	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I32_RS02315	COG3250	beta-galactosidase activity
I6I32_RS02325	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I32_RS02335	COG1126	abc transporter atp-binding protein
I6I32_RS02340	COG0765	amino acid transport
I6I32_RS02345	COG4703	Protein of unknown function (DUF1797)
I6I32_RS02350	COG0542	response to heat
I6I32_RS02355	COG0494	nUDIX hydrolase
I6I32_RS02375	COG0513	Belongs to the DEAD box helicase family
I6I32_RS02385	COG2190	(PTS) system
I6I32_RS02385	COG1263	PTS System
I6I32_RS02385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I32_RS02390	COG2177	Part of the ABC transporter FtsEX involved in
I6I32_RS02395	COG2884	Cell division ATP-binding protein ftsE
I6I32_RS02405	COG0517	IMP dehydrogenase activity
I6I32_RS02405	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6I32_RS02405	COG0617	tRNA 3'-terminal CCA addition
I6I32_RS02440	COG0740	serine-type endopeptidase activity
I6I32_RS02445	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I32_RS02450	COG2131	deaminase
I6I32_RS02460	COG1307	EDD domain protein, DegV family
I6I32_RS02465	COG2081	HI0933 family
I6I32_RS02475	COG0789	Transcriptional regulator
I6I32_RS02480	COG0733	neurotransmitter:sodium symporter activity
I6I32_RS02485	COG1482	cell wall glycoprotein biosynthetic process
I6I32_RS02490	COG2723	6-phospho-beta-galactosidase activity
I6I32_RS02505	COG0028	Belongs to the TPP enzyme family
I6I32_RS02510	COG2217	Heavy metal translocating P-type atpase
I6I32_RS02530	COG0352	thiamine-phosphate diphosphorylase activity
I6I32_RS02545	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I32_RS02555	COG4172	Belongs to the ABC transporter superfamily
I6I32_RS02570	COG1304	FMN binding
I6I32_RS02580	COG4215	(ABC) transporter
I6I32_RS02585	COG1126	abc transporter atp-binding protein
I6I32_RS02590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I32_RS02605	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6I32_RS02625	COG1217	gtp-binding protein TYPA
I6I32_RS02630	COG1187	pseudouridine synthase activity
I6I32_RS02650	COG0583	DNA-binding transcription factor activity
I6I32_RS02655	COG2247	cell wall binding repeat
I6I32_RS02655	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I32_RS02710	COG4555	ABC transporter
I6I32_RS02720	COG0191	fructose-bisphosphate aldolase activity
I6I32_RS02725	COG5002	protein histidine kinase activity
I6I32_RS02730	COG0745	RESPONSE REGULATOR receiver
I6I32_RS02735	COG0577	efflux transmembrane transporter activity
I6I32_RS02740	COG1136	(ABC) transporter
I6I32_RS02745	COG0577	efflux transmembrane transporter activity
I6I32_RS02755	COG1335	isochorismatase
I6I32_RS02760	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6I32_RS02765	COG0513	Belongs to the DEAD box helicase family
I6I32_RS02770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I32_RS02775	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I32_RS02780	COG3442	glutamine amidotransferase
I6I32_RS02785	COG0006	proline dipeptidase activity
I6I32_RS02790	COG4720	Psort location CytoplasmicMembrane, score
I6I32_RS02795	COG0351	phosphomethylpyrimidine kinase
I6I32_RS02815	COG2824	Alkylphosphonate utilization operon protein PhnA
I6I32_RS02825	COG0149	triose-phosphate isomerase activity
I6I32_RS02830	COG3935	DnaD domain protein
I6I32_RS02840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I32_RS02865	COG1363	Peptidase, m42
I6I32_RS02870	COG4808	Protein conserved in bacteria
I6I32_RS02880	COG1114	Component of the transport system for branched-chain amino acids
I6I32_RS02885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I32_RS02885	COG0425	Belongs to the sulfur carrier protein TusA family
I6I32_RS02890	COG1573	uracil-dna glycosylase
I6I32_RS02915	COG0322	excinuclease ABC activity
I6I32_RS02920	COG5549	protein import
I6I32_RS02920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I32_RS02935	COG3942	CHAP domain
I6I32_RS02940	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6I32_RS02940	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6I32_RS02950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I32_RS02955	COG0765	amino acid transport
I6I32_RS02960	COG0765	amino acid transport
I6I32_RS02975	COG1959	2 iron, 2 sulfur cluster binding
I6I32_RS03000	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I32_RS03010	COG0745	RESPONSE REGULATOR receiver
I6I32_RS03035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I32_RS03045	COG3590	peptidase
I6I32_RS03065	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6I32_RS03085	COG3842	ATPase activity
I6I32_RS03095	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6I32_RS03100	COG0215	cysteine-tRNA ligase activity
I6I32_RS03120	COG1045	serine acetyltransferase
I6I32_RS03135	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6I32_RS03140	COG3620	sequence-specific DNA binding
I6I32_RS03145	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
I6I32_RS03185	COG1940	carbohydrate kinase activity
I6I32_RS03190	COG1263	PTS System
I6I32_RS03190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I32_RS03190	COG2190	(PTS) system
I6I32_RS03195	COG1621	beta-fructofuranosidase activity
I6I32_RS03200	COG1609	Transcriptional regulator
I6I32_RS03210	COG3425	synthase
I6I32_RS03225	COG0515	serine threonine protein kinase
I6I32_RS03225	COG2815	serine threonine protein kinase
I6I32_RS03230	COG0631	protein serine/threonine phosphatase activity
I6I32_RS03235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I32_RS03235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I32_RS03245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I32_RS03255	COG0194	GDP metabolic process
I6I32_RS03265	COG4115	mRNA cleavage
I6I32_RS03280	COG2226	methyltransferase
I6I32_RS03285	COG0799	negative regulation of ribosome biogenesis
I6I32_RS03290	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6I32_RS03295	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6I32_RS03300	COG1534	Rna-binding protein
I6I32_RS03305	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6I32_RS03310	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6I32_RS03320	COG0668	transmembrane transport
I6I32_RS03325	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6I32_RS03345	COG0438	transferase activity, transferring glycosyl groups
I6I32_RS03350	COG0438	transferase activity, transferring glycosyl groups
I6I32_RS03355	COG0653	protein targeting
I6I32_RS03375	COG0201	protein transport
I6I32_RS03380	COG1442	glycosyl transferase family 8
I6I32_RS03385	COG1442	glycosyl transferase family 8
I6I32_RS03395	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I32_RS03415	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I32_RS03455	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6I32_RS03460	COG0439	Biotin carboxylase
I6I32_RS03475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I32_RS03480	COG1028	Short-chain dehydrogenase reductase Sdr
I6I32_RS03485	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6I32_RS03495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I32_RS03505	COG1846	Transcriptional regulator
I6I32_RS03510	COG1024	Enoyl-CoA hydratase
I6I32_RS03515	COG0527	aspartate kinase activity
I6I32_RS03540	COG1115	amino acid carrier protein
I6I32_RS03565	COG0681	Belongs to the peptidase S26 family
I6I32_RS03570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I32_RS03575	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I32_RS03585	COG2197	response regulator
I6I32_RS03590	COG4585	Histidine kinase
I6I32_RS03630	COG0745	RESPONSE REGULATOR receiver
I6I32_RS03635	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6I32_RS03645	COG0116	Belongs to the methyltransferase superfamily
I6I32_RS03680	COG0366	Alpha amylase catalytic
I6I32_RS03685	COG4166	transmembrane transport
I6I32_RS03690	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6I32_RS03695	COG1088	dTDP-glucose 4,6-dehydratase activity
I6I32_RS03705	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6I32_RS03710	COG0438	transferase activity, transferring glycosyl groups
I6I32_RS03715	COG0562	UDP-galactopyranose mutase
I6I32_RS03730	COG1442	glycosyl transferase family 8
I6I32_RS03730	COG1216	Glycosyl transferase, family 2
I6I32_RS03745	COG0297	glycogen (starch) synthase activity
I6I32_RS03760	COG0489	protein tyrosine kinase activity
I6I32_RS03765	COG3944	biosynthesis protein
I6I32_RS03770	COG4464	protein tyrosine phosphatase activity
I6I32_RS03780	COG4166	transmembrane transport
I6I32_RS03785	COG4166	transmembrane transport
I6I32_RS03805	COG0281	malic enzyme
I6I32_RS03815	COG0583	DNA-binding transcription factor activity
I6I32_RS03825	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6I32_RS03830	COG1668	transmembrane transport
I6I32_RS03835	COG4152	abc transporter atp-binding protein
I6I32_RS03840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I32_RS03840	COG0072	phenylalanine-tRNA ligase activity
I6I32_RS03850	COG0671	phosphoesterase, PA-phosphatase related
I6I32_RS03855	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I6I32_RS03865	COG0569	domain protein
I6I32_RS03870	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I32_RS03875	COG4608	Belongs to the ABC transporter superfamily
I6I32_RS03880	COG0444	Belongs to the ABC transporter superfamily
I6I32_RS03885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I32_RS03890	COG0601	transmembrane transport
I6I32_RS03895	COG4166	transmembrane transport
I6I32_RS03905	COG1253	flavin adenine dinucleotide binding
I6I32_RS03920	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I32_RS03930	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6I32_RS03940	COG0742	ribosomal rna small subunit methyltransferase
I6I32_RS03955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I32_RS03960	COG1254	Belongs to the acylphosphatase family
I6I32_RS03970	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6I32_RS03980	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I32_RS03985	COG3481	metal-dependent phosphohydrolase, HD sub domain
I6I32_RS03995	COG1564	THIamine pyrophosphokinase
I6I32_RS04005	COG1162	GTPase activity
I6I32_RS04030	COG0084	hydrolase, TatD family'
I6I32_RS04035	COG0531	amino acid
I6I32_RS04045	COG0436	Aminotransferase
I6I32_RS04055	COG0589	response to stress
I6I32_RS04065	COG0561	phosphatase activity
I6I32_RS04070	COG0252	asparaginase activity
I6I32_RS04075	COG1609	Transcriptional regulator
I6I32_RS04090	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6I32_RS04090	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6I32_RS04100	COG0285	dihydrofolate synthase activity
I6I32_RS04105	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6I32_RS04115	COG2252	PERMEase
I6I32_RS04120	COG0561	phosphatase activity
I6I32_RS04130	COG3715	PTS system
I6I32_RS04135	COG3716	PTS system mannose fructose sorbose family IID component
I6I32_RS04140	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I32_RS04145	COG3579	cysteine-type endopeptidase activity
I6I32_RS04150	COG1187	pseudouridine synthase activity
I6I32_RS04155	COG2261	transglycosylase associated protein
I6I32_RS04160	COG2309	aminopeptidase activity
I6I32_RS04170	COG2176	DNA-directed DNA polymerase activity
I6I32_RS04260	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I32_RS04265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I32_RS04280	COG1012	belongs to the aldehyde dehydrogenase family
I6I32_RS04280	COG1454	alcohol dehydrogenase
I6I32_RS04300	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I32_RS04315	COG0706	membrane insertase activity
I6I32_RS04360	COG4537	Required for transformation and DNA binding
I6I32_RS04365	COG1459	type II secretion system
I6I32_RS04370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I32_RS04400	COG3759	membrane
I6I32_RS04405	COG1846	Transcriptional regulator
I6I32_RS04415	COG0546	phosphoglycolate phosphatase activity
I6I32_RS04420	COG0534	Mate efflux family protein
I6I32_RS04530	COG0166	Belongs to the GPI family
I6I32_RS04535	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6I32_RS04540	COG1132	(ABC) transporter
I6I32_RS04545	COG1132	(ABC) transporter
I6I32_RS04555	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I32_RS04560	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
I6I32_RS04565	COG1518	maintenance of DNA repeat elements
I6I32_RS04570	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I6I32_RS04585	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I32_RS04600	COG0697	spore germination
I6I32_RS04605	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6I32_RS04605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I32_RS04615	COG2226	methyltransferase
I6I32_RS04620	COG0058	SHG alpha-glucan phosphorylase activity
I6I32_RS04625	COG1640	4-alpha-glucanotransferase
I6I32_RS04630	COG2182	Extracellular solute-binding protein
I6I32_RS04635	COG1175	transmembrane transport
I6I32_RS04640	COG3833	ABC-type maltose transport systems, permease component
I6I32_RS04645	COG5521	maltodextrose utilization protein MalA
I6I32_RS04650	COG1609	Transcriptional regulator
I6I32_RS04655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6I32_RS04690	COG1476	TRANSCRIPTIONal
I6I32_RS04695	COG0124	histidyl-tRNA synthetase
I6I32_RS04700	COG2151	metal-sulfur cluster biosynthetic enzyme
I6I32_RS04715	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I32_RS04780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I32_RS04785	COG3620	sequence-specific DNA binding
I6I32_RS04800	COG3620	sequence-specific DNA binding
I6I32_RS04815	COG1674	ftsk spoiiie
I6I32_RS04850	COG0433	COG0433 Predicted ATPase
I6I32_RS04865	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6I32_RS04865	COG3942	CHAP domain
I6I32_RS04875	COG4974	Belongs to the 'phage' integrase family
I6I32_RS04985	COG0582	viral genome integration into host DNA
I6I32_RS04995	COG5002	protein histidine kinase activity
I6I32_RS05000	COG0745	RESPONSE REGULATOR receiver
I6I32_RS05015	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I32_RS05025	COG1309	transcriptional regulator
I6I32_RS05045	COG0110	maltose O-acetyltransferase activity
I6I32_RS05050	COG0425	Belongs to the sulfur carrier protein TusA family
I6I32_RS05050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I32_RS05055	COG0425	Belongs to the sulfur carrier protein TusA family
I6I32_RS05055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I32_RS05060	COG1937	Protein conserved in bacteria
I6I32_RS05090	COG2514	catechol 2,3-dioxygenase activity
I6I32_RS05100	COG3684	Belongs to the aldolase LacD family
I6I32_RS05105	COG2222	sugar isomerase
I6I32_RS05115	COG3716	PTS system mannose fructose sorbose family IID component
I6I32_RS05120	COG3715	PTS system
I6I32_RS05125	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I32_RS05140	COG3064	Membrane
I6I32_RS05140	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6I32_RS05140	COG3583	domain protein
I6I32_RS05145	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6I32_RS05165	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6I32_RS05170	COG0151	Belongs to the GarS family
I6I32_RS05175	COG0138	bifunctional purine biosynthesis protein purh
I6I32_RS05185	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6I32_RS05190	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I32_RS05200	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I32_RS05210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I32_RS05215	COG2274	protein secretion by the type I secretion system
I6I32_RS05255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I32_RS05270	COG0436	Aminotransferase
I6I32_RS05275	COG2855	membrane
I6I32_RS05280	COG1832	CoA-binding protein
I6I32_RS05285	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I32_RS05295	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6I32_RS05310	COG0756	dUTP diphosphatase activity
I6I32_RS05365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I32_RS05370	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6I32_RS05390	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6I32_RS05395	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I32_RS05405	COG0012	GTP binding
I6I32_RS05415	COG0592	DNA-directed DNA polymerase activity
I6I32_RS05425	COG1475	DNA binding
I6I32_RS05430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I32_RS05475	COG1511	domain protein
I6I32_RS05475	COG1511	domain protein
I6I32_RS05485	COG0488	(ABC) transporter
I6I32_RS05490	COG0180	Tryptophanyl-tRNA synthetase
I6I32_RS05495	COG0516	GMP reductase activity
I6I32_RS05495	COG0517	IMP dehydrogenase activity
I6I32_RS05505	COG2501	S4 domain
I6I32_RS05510	COG0612	Peptidase, M16
I6I32_RS05515	COG0612	Peptidase, M16
I6I32_RS05525	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I32_RS05530	COG1122	ATPase activity
I6I32_RS05535	COG1122	ATPase activity
I6I32_RS05540	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6I32_RS05545	COG1792	Involved in formation and maintenance of cell shape
I6I32_RS05555	COG3942	CHAP domain
I6I32_RS05580	COG1739	Uncharacterized protein family UPF0029
I6I32_RS05585	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6I32_RS05590	COG1040	competence protein
I6I32_RS05605	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I6I32_RS05615	COG0305	Participates in initiation and elongation during chromosome replication
I6I32_RS05625	COG3942	CHAP domain
I6I32_RS05635	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I32_RS05635	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I32_RS05645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I32_RS05650	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I32_RS05655	COG1116	anion transmembrane transporter activity
I6I32_RS05665	COG4463	regulation of RNA biosynthetic process
I6I32_RS05670	COG0542	response to heat
I6I32_RS05680	COG3201	nicotinamide mononucleotide transporter
I6I32_RS05700	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I32_RS05720	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6I32_RS05725	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I32_RS05740	COG1696	Membrane protein involved in D-alanine export
I6I32_RS05745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I32_RS05750	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6I32_RS05755	COG0737	Belongs to the 5'-nucleotidase family
I6I32_RS05760	COG1846	Transcriptional regulator
I6I32_RS05765	COG1121	(ABC) transporter
I6I32_RS05770	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I32_RS05775	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6I32_RS05775	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I32_RS05785	COG3537	Alpha-1,2-mannosidase
I6I32_RS05800	COG0383	alpha-mannosidase activity
I6I32_RS05815	COG4209	transmembrane transport
I6I32_RS05820	COG0395	ABC-type sugar transport system, permease component
I6I32_RS05825	COG1653	transport
I6I32_RS05870	COG2807	transmembrane transport
I6I32_RS05875	COG1216	Glycosyl transferase, family 2
I6I32_RS05895	COG0546	phosphoglycolate phosphatase activity
I6I32_RS05900	COG1760	l-serine dehydratase
I6I32_RS05905	COG1760	l-serine dehydratase
I6I32_RS05910	COG3584	3D domain protein
I6I32_RS05910	COG1388	LysM domain
I6I32_RS05925	COG0577	efflux transmembrane transporter activity
I6I32_RS05925	COG1136	(ABC) transporter
I6I32_RS05930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I32_RS05935	COG0137	argininosuccinate synthase activity
I6I32_RS05950	COG0494	nUDIX hydrolase
I6I32_RS05955	COG0445	tRNA wobble uridine modification
I6I32_RS05990	COG3177	Filamentation induced by cAMP protein fic
I6I32_RS06005	COG1214	PFAM Peptidase M22, glycoprotease
I6I32_RS06015	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6I32_RS06020	COG1396	sequence-specific DNA binding
I6I32_RS06045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I32_RS06050	COG1464	Belongs to the NlpA lipoprotein family
I6I32_RS06055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I32_RS06060	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I32_RS06080	COG2972	Histidine kinase
I6I32_RS06085	COG2207	Transcriptional regulator
I6I32_RS06085	COG4753	response regulator
I6I32_RS06095	COG1780	Probably involved in ribonucleotide reductase function
I6I32_RS06115	COG1438	arginine binding
I6I32_RS06140	COG1395	domain, Protein
I6I32_RS06155	COG2818	Glycosylase
I6I32_RS06185	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I32_RS06195	COG0006	proline dipeptidase activity
I6I32_RS06200	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I32_RS06205	COG1393	Belongs to the ArsC family
I6I32_RS06230	COG0285	dihydrofolate synthase activity
I6I32_RS06240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I32_RS06255	COG1328	CTP reductase activity
I6I32_RS06270	COG0602	queuosine metabolic process
I6I32_RS06305	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I32_RS06330	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I32_RS06350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I32_RS06360	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I32_RS06370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I32_RS06385	COG0201	protein transport
I6I32_RS06395	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6I32_RS06400	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I32_RS06410	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6I32_RS06415	COG0202	RNA polymerase activity
I6I32_RS06425	COG3830	Belongs to the UPF0237 family
I6I32_RS06430	COG2848	UPF0210 protein
I6I32_RS06435	COG0588	phosphoglycerate mutase activity
I6I32_RS06440	COG1178	ABC-type Fe3 transport system permease component
I6I32_RS06445	COG3842	ATPase activity
I6I32_RS06450	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I32_RS06490	COG2255	four-way junction helicase activity
I6I32_RS06500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I32_RS06505	COG4589	Belongs to the CDS family
I6I32_RS06510	COG0750	zinc metalloprotease
I6I32_RS06520	COG2723	6-phospho-beta-galactosidase activity
I6I32_RS06530	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6I32_RS06540	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I6I32_RS06560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I32_RS06565	COG0765	amino acid transport
I6I32_RS06570	COG0765	amino acid transport
I6I32_RS06575	COG1126	abc transporter atp-binding protein
I6I32_RS06580	COG1523	belongs to the glycosyl hydrolase 13 family
I6I32_RS06605	COG0802	atpase or kinase
I6I32_RS06615	COG1316	TRANSCRIPTIONal
I6I32_RS06640	COG0534	Mate efflux family protein
I6I32_RS06685	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6I32_RS06695	COG1461	Dihydroxyacetone kinase
I6I32_RS06715	COG1131	(ABC) transporter
I6I32_RS06725	COG4585	Histidine kinase
I6I32_RS06730	COG2197	response regulator
I6I32_RS06750	COG0028	Belongs to the TPP enzyme family
I6I32_RS06755	COG0440	acetolactate synthase activity
I6I32_RS06765	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I32_RS06785	COG0765	amino acid transport
I6I32_RS06810	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I32_RS06815	COG1882	Formate acetyltransferase
I6I32_RS06840	COG0366	Alpha amylase catalytic
I6I32_RS06845	COG0366	Alpha amylase catalytic
I6I32_RS06850	COG0386	Belongs to the glutathione peroxidase family
I6I32_RS06855	COG5492	domain, Protein
I6I32_RS06875	COG1028	Short-chain dehydrogenase reductase Sdr
I6I32_RS06885	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6I32_RS06890	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I32_RS06895	COG3715	PTS system
I6I32_RS06900	COG3716	PTS system mannose fructose sorbose family IID component
I6I32_RS06915	COG1609	Transcriptional regulator
I6I32_RS06945	COG4839	cell division protein FtsL
I6I32_RS06950	COG0768	penicillin binding
I6I32_RS06960	COG0366	Alpha amylase catalytic
I6I32_RS06965	COG2188	Transcriptional regulator
I6I32_RS06970	COG1263	PTS System
I6I32_RS06970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I32_RS06975	COG0366	Alpha amylase catalytic
I6I32_RS06990	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6I32_RS07000	COG0517	IMP dehydrogenase activity
I6I32_RS07020	COG1187	pseudouridine synthase activity
I6I32_RS07030	COG4607	ABC-type enterochelin transport system periplasmic component
I6I32_RS07035	COG4604	ABC transporter, ATP-binding protein
I6I32_RS07040	COG4605	iron ion homeostasis
I6I32_RS07045	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I32_RS07050	COG1363	Peptidase, m42
I6I32_RS07075	COG2378	regulation of single-species biofilm formation
I6I32_RS07080	COG0126	phosphoglycerate kinase activity
I6I32_RS07095	COG0789	Transcriptional regulator
I6I32_RS07100	COG0174	glutamine synthetase
I6I32_RS07130	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6I32_RS07145	COG0484	heat shock protein binding
I6I32_RS07160	COG0537	adenosine 5'-monophosphoramidase activity
I6I32_RS07165	COG1131	(ABC) transporter
I6I32_RS07190	COG0195	Participates in both transcription termination and antitermination
I6I32_RS07195	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6I32_RS07245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I32_RS07255	COG0525	valine-tRNA ligase activity
I6I32_RS07300	COG0504	CTP synthase activity
I6I32_RS07315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I32_RS07320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I32_RS07325	COG4221	oxidoreductase activity
I6I32_RS07360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I32_RS07480	COG2207	Transcriptional regulator
I6I32_RS07485	COG3345	alpha-galactosidase
I6I32_RS07490	COG1653	transport
I6I32_RS07495	COG1175	transmembrane transport
I6I32_RS07500	COG0395	ABC-type sugar transport system, permease component
I6I32_RS07505	COG0366	Alpha amylase catalytic
I6I32_RS07525	COG1125	glycine betaine transport
I6I32_RS07525	COG0517	IMP dehydrogenase activity
I6I32_RS07530	COG1174	glycine betaine transport
I6I32_RS07540	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6I32_RS07550	COG1122	ATPase activity
I6I32_RS07595	COG1230	cation diffusion facilitator family transporter
I6I32_RS07605	COG1063	alcohol dehydrogenase
I6I32_RS07610	COG1609	Transcriptional regulator
I6I32_RS07615	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6I32_RS07620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I32_RS07625	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I6I32_RS07645	COG2233	PERMEase
I6I32_RS07660	COG0708	Exodeoxyribonuclease III
I6I32_RS07670	COG2323	membrane
I6I32_RS07675	COG1132	(ABC) transporter
I6I32_RS07680	COG1132	(ABC) transporter
I6I32_RS07685	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I32_RS07695	COG0133	tryptophan synthase activity
I6I32_RS07700	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6I32_RS07705	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I32_RS07745	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6I32_RS07765	COG3237	CsbD-like
I6I32_RS07785	COG2261	transglycosylase associated protein
I6I32_RS07790	COG3711	transcriptional antiterminator
I6I32_RS07810	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I32_RS07825	COG1051	belongs to the nudix hydrolase family
I6I32_RS07835	COG2264	protein methyltransferase activity
I6I32_RS07840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I32_RS07845	COG1164	Oligoendopeptidase f
I6I32_RS07860	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I32_RS07875	COG0720	synthase
I6I32_RS07885	COG3118	belongs to the thioredoxin family
I6I32_RS07905	COG1346	cytolysis
I6I32_RS07910	COG1136	(ABC) transporter
I6I32_RS07920	COG1131	(ABC) transporter
I6I32_RS07925	COG1725	Transcriptional regulator
I6I32_RS07940	COG1484	DNA-dependent DNA replication
I6I32_RS07985	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I32_RS07990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I32_RS08005	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I32_RS08010	COG3458	cephalosporin-C deacetylase activity
I6I32_RS08030	COG1175	transmembrane transport
I6I32_RS08035	COG0395	ABC-type sugar transport system, permease component
I6I32_RS08040	COG2731	YhcH YjgK YiaL family protein
I6I32_RS08050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I32_RS08060	COG2226	methyltransferase
I6I32_RS08070	COG0768	penicillin binding
I6I32_RS08085	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I32_RS08105	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6I32_RS08125	COG3599	regulation of cell shape
I6I32_RS08130	COG3599	regulation of cell shape
I6I32_RS08135	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I32_RS08140	COG3583	domain protein
I6I32_RS08140	COG3583	domain protein
I6I32_RS08145	COG3583	domain protein
I6I32_RS08155	COG3583	domain protein
I6I32_RS08155	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6I32_RS08175	COG1309	transcriptional regulator
I6I32_RS08180	COG0577	efflux transmembrane transporter activity
I6I32_RS08180	COG1136	(ABC) transporter
I6I32_RS08200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I32_RS08215	COG2382	esterase
I6I32_RS08220	COG0204	Acyl-transferase
I6I32_RS08225	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I32_RS08230	COG2384	SAM-dependent methyltransferase
I6I32_RS08235	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I32_RS08240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I32_RS08245	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I32_RS08250	COG0463	Glycosyl transferase, family 2
I6I32_RS08270	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6I32_RS08285	COG0251	oxidation-reduction process
I6I32_RS08295	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6I32_RS08305	COG0492	ferredoxin-NADP+ reductase activity
I6I32_RS08310	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6I32_RS08330	COG1307	EDD domain protein, DegV family
I6I32_RS08340	COG0617	tRNA 3'-terminal CCA addition
I6I32_RS08345	COG0488	(ABC) transporter
I6I32_RS08355	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6I32_RS08365	COG0242	peptide deformylase activity
I6I32_RS08390	COG1846	Transcriptional regulator
I6I32_RS08400	COG0436	Aminotransferase
I6I32_RS08405	COG0017	Asparaginyl-tRNA synthetase
I6I32_RS08410	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I32_RS08415	COG0629	single-stranded DNA binding
I6I32_RS08420	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6I32_RS08430	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6I32_RS08440	COG1215	transferase activity, transferring glycosyl groups
I6I32_RS08445	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6I32_RS08455	COG1098	S1 RNA binding domain
I6I32_RS08460	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6I32_RS08465	COG2827	Endonuclease containing a URI domain
I6I32_RS08490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I32_RS08495	COG2244	polysaccharide biosynthetic process
I6I32_RS08500	COG4166	transmembrane transport
I6I32_RS08505	COG0626	cystathionine gamma-synthase activity
I6I32_RS08510	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6I32_RS08515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I32_RS08540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6I32_RS08550	COG1113	amino acid transport
I6I32_RS08555	COG0454	-acetyltransferase
I6I32_RS08580	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I32_RS08590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I32_RS08595	COG0785	Cytochrome C biogenesis protein
I6I32_RS08600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I32_RS08605	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I32_RS08605	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I32_RS08610	COG2207	Transcriptional regulator
I6I32_RS08610	COG4753	response regulator
I6I32_RS08615	COG2972	Histidine kinase
I6I32_RS08630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6I32_RS08650	COG1940	carbohydrate kinase activity
I6I32_RS08660	COG1396	sequence-specific DNA binding
I6I32_RS08665	COG0535	radical SAM domain protein
I6I32_RS08670	COG1132	(ABC) transporter
I6I32_RS08685	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I32_RS08690	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I6I32_RS08700	COG0300	oxidoreductase activity
I6I32_RS08705	COG3250	beta-galactosidase activity
I6I32_RS08720	COG2226	methyltransferase
I6I32_RS08730	COG1242	4 iron, 4 sulfur cluster binding
I6I32_RS08735	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6I32_RS08745	COG0025	NhaP-type Na H and K H
I6I32_RS08770	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6I32_RS08800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I32_RS08810	COG0647	UMP catabolic process
I6I32_RS08820	COG1393	Belongs to the ArsC family
I6I32_RS08830	COG0483	inositol monophosphate 1-phosphatase activity
I6I32_RS08835	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6I32_RS08835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I32_RS08840	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I32_RS08845	COG0581	inorganic phosphate transmembrane transporter activity
I6I32_RS08850	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I32_RS08855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I32_RS08860	COG0704	Plays a role in the regulation of phosphate uptake
I6I32_RS08865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I32_RS08870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I32_RS08875	COG3527	Alpha-acetolactate decarboxylase
I6I32_RS08890	COG3842	ATPase activity
I6I32_RS08925	COG1337	RAMP superfamily
I6I32_RS08930	COG1567	CRISPR-associated RAMP protein, Csm4 family
I6I32_RS08950	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I32_RS08960	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I32_RS08985	COG0287	Prephenate dehydrogenase
I6I32_RS08990	COG3679	Belongs to the UPF0342 family
I6I32_RS09005	COG0077	Prephenate dehydratase
I6I32_RS09015	COG3475	LICD family
I6I32_RS09020	COG1442	glycosyl transferase family 8
I6I32_RS09020	COG1216	Glycosyl transferase, family 2
I6I32_RS09025	COG3475	LICD family
I6I32_RS09060	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I32_RS09060	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I32_RS09065	COG1132	(ABC) transporter
I6I32_RS09075	COG0402	S-adenosylhomocysteine deaminase activity
I6I32_RS09080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I32_RS09085	COG0222	ribosome binding
I6I32_RS09090	COG5504	Zn-dependent protease
I6I32_RS09105	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I32_RS09110	COG0167	dihydroorotate dehydrogenase activity
I6I32_RS09120	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I32_RS09125	COG4470	Protein conserved in bacteria
I6I32_RS09130	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I32_RS09140	COG0488	(ABC) transporter
I6I32_RS09150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I32_RS09185	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I32_RS09185	COG1328	CTP reductase activity
I6I32_RS09195	COG4443	Transcriptional Coactivator p15 (PC4)
I6I32_RS09210	COG1268	BioY protein
I6I32_RS09215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I32_RS09220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I32_RS09225	COG1136	(ABC) transporter
I6I32_RS09230	COG0577	efflux transmembrane transporter activity
I6I32_RS09235	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I32_RS09235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I32_RS09260	COG2813	Specifically methylates the guanine in position
I6I32_RS09265	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6I32_RS09275	COG0295	cytidine deaminase activity
I6I32_RS09280	COG1744	ABC transporter substrate-binding protein PnrA-like
I6I32_RS09285	COG3845	ABC transporter
I6I32_RS09290	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6I32_RS09295	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6I32_RS09305	COG0187	DNA topoisomerase II activity
I6I32_RS09325	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6I32_RS09330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I32_RS09350	COG0539	negative regulation of cytoplasmic translation
I6I32_RS09355	COG1956	GAF domain-containing protein
I6I32_RS09360	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6I32_RS09375	COG0719	Fe-S assembly protein
I6I32_RS09380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I32_RS09390	COG0719	Fe-S assembly protein
I6I32_RS09400	COG0531	amino acid
I6I32_RS09405	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6I32_RS09410	COG1307	EDD domain protein, DegV family
I6I32_RS09420	COG0039	L-malate dehydrogenase activity
I6I32_RS09425	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6I32_RS09430	COG3764	Sortase (surface protein transpeptidase)
I6I32_RS09455	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I32_RS09480	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6I32_RS09485	COG1438	arginine binding
I6I32_RS09490	COG0497	DNA recombination
I6I32_RS09495	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I32_RS09510	COG0758	DNA mediated transformation
I6I32_RS09515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I32_RS09520	COG2832	Protein of unknown function (DUF454)
I6I32_RS09525	COG3142	Participates in the control of copper homeostasis
I6I32_RS09540	COG0473	3-isopropylmalate dehydrogenase activity