locus-tag	class	description
CO686_RS00015	COG0706	membrane insertase activity
CO686_RS00020	COG1847	R3H domain protein
CO686_RS00030	COG3037	sugar-specific permease SgaT UlaA
CO686_RS00040	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO686_RS00050	COG3623	hexulose-6-phosphate isomerase
CO686_RS00070	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CO686_RS00090	COG1012	belongs to the aldehyde dehydrogenase family
CO686_RS00090	COG1454	alcohol dehydrogenase
CO686_RS00105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CO686_RS00110	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CO686_RS00205	COG2176	DNA-directed DNA polymerase activity
CO686_RS00220	COG0419	ATPase involved in DNA repair
CO686_RS00240	COG2309	aminopeptidase activity
CO686_RS00245	COG2261	transglycosylase associated protein
CO686_RS00255	COG1187	pseudouridine synthase activity
CO686_RS00265	COG3579	cysteine-type endopeptidase activity
CO686_RS00270	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CO686_RS00275	COG3716	PTS system mannose fructose sorbose family IID component
CO686_RS00280	COG3715	PTS system
CO686_RS00290	COG0561	phosphatase activity
CO686_RS00295	COG2252	PERMEase
CO686_RS00305	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CO686_RS00310	COG0285	dihydrofolate synthase activity
CO686_RS00320	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CO686_RS00320	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CO686_RS00335	COG1609	Transcriptional regulator
CO686_RS00340	COG0252	asparaginase activity
CO686_RS00345	COG0561	phosphatase activity
CO686_RS00355	COG0589	response to stress
CO686_RS00365	COG0436	Aminotransferase
CO686_RS00375	COG0531	amino acid
CO686_RS00380	COG0084	hydrolase, TatD family'
CO686_RS00395	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CO686_RS00400	COG1162	GTPase activity
CO686_RS00410	COG1564	THIamine pyrophosphokinase
CO686_RS00420	COG3481	metal-dependent phosphohydrolase, HD sub domain
CO686_RS00425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CO686_RS00435	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CO686_RS00445	COG1254	Belongs to the acylphosphatase family
CO686_RS00450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CO686_RS00465	COG0742	ribosomal rna small subunit methyltransferase
CO686_RS00475	COG3480	Lon protease (S16) C-terminal proteolytic domain
CO686_RS00485	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CO686_RS00500	COG1253	flavin adenine dinucleotide binding
CO686_RS00510	COG4166	transmembrane transport
CO686_RS00515	COG0601	transmembrane transport
CO686_RS00520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO686_RS00525	COG0444	Belongs to the ABC transporter superfamily
CO686_RS00530	COG4608	Belongs to the ABC transporter superfamily
CO686_RS00535	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CO686_RS00540	COG0569	domain protein
CO686_RS00555	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CO686_RS00560	COG0671	phosphoesterase, PA-phosphatase related
CO686_RS00570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO686_RS00570	COG0072	phenylalanine-tRNA ligase activity
CO686_RS00575	COG4152	abc transporter atp-binding protein
CO686_RS00580	COG1668	transmembrane transport
CO686_RS00585	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CO686_RS00595	COG0582	viral genome integration into host DNA
CO686_RS00720	COG4499	WXG100 protein secretion system (Wss), protein YukC
CO686_RS00835	COG3620	sequence-specific DNA binding
CO686_RS00840	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CO686_RS00860	COG0366	Alpha amylase catalytic
CO686_RS00865	COG0386	Belongs to the glutathione peroxidase family
CO686_RS00915	COG4839	cell division protein FtsL
CO686_RS00920	COG0768	penicillin binding
CO686_RS00930	COG0366	Alpha amylase catalytic
CO686_RS00935	COG2188	Transcriptional regulator
CO686_RS00940	COG1263	PTS System
CO686_RS00940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO686_RS00945	COG0366	Alpha amylase catalytic
CO686_RS00975	COG0517	IMP dehydrogenase activity
CO686_RS00995	COG1187	pseudouridine synthase activity
CO686_RS01005	COG4607	ABC-type enterochelin transport system periplasmic component
CO686_RS01010	COG4604	ABC transporter, ATP-binding protein
CO686_RS01015	COG4605	iron ion homeostasis
CO686_RS01020	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CO686_RS01025	COG1363	Peptidase, m42
CO686_RS01055	COG2378	regulation of single-species biofilm formation
CO686_RS01060	COG0126	phosphoglycerate kinase activity
CO686_RS01065	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CO686_RS01065	COG3064	Membrane
CO686_RS01075	COG0789	Transcriptional regulator
CO686_RS01080	COG0174	glutamine synthetase
CO686_RS01095	COG4932	domain protein
CO686_RS01095	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CO686_RS01095	COG3583	domain protein
CO686_RS01125	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CO686_RS01150	COG0484	heat shock protein binding
CO686_RS01165	COG0537	adenosine 5'-monophosphoramidase activity
CO686_RS01170	COG1131	(ABC) transporter
CO686_RS01195	COG0195	Participates in both transcription termination and antitermination
CO686_RS01200	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CO686_RS01255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CO686_RS01265	COG0525	valine-tRNA ligase activity
CO686_RS01275	COG0326	Molecular chaperone. Has ATPase activity
CO686_RS01305	COG0504	CTP synthase activity
CO686_RS01315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CO686_RS01320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO686_RS01325	COG4221	oxidoreductase activity
CO686_RS01360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CO686_RS01485	COG2207	Transcriptional regulator
CO686_RS01490	COG3345	alpha-galactosidase
CO686_RS01495	COG1653	transport
CO686_RS01500	COG1175	transmembrane transport
CO686_RS01505	COG0395	ABC-type sugar transport system, permease component
CO686_RS01510	COG0366	Alpha amylase catalytic
CO686_RS01530	COG1174	glycine betaine transport
CO686_RS01535	COG3201	nicotinamide mononucleotide transporter
CO686_RS01550	COG1230	cation diffusion facilitator family transporter
CO686_RS01555	COG0789	Transcriptional regulator
CO686_RS01565	COG1609	Transcriptional regulator
CO686_RS01570	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CO686_RS01580	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CO686_RS01605	COG2233	PERMEase
CO686_RS01620	COG0708	Exodeoxyribonuclease III
CO686_RS01635	COG1132	(ABC) transporter
CO686_RS01640	COG1132	(ABC) transporter
CO686_RS01650	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CO686_RS01655	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CO686_RS01660	COG0133	tryptophan synthase activity
CO686_RS01665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CO686_RS01670	COG0512	Glutamine amidotransferase of anthranilate synthase
CO686_RS01720	COG3237	CsbD-like
CO686_RS01740	COG2261	transglycosylase associated protein
CO686_RS01745	COG3711	transcriptional antiterminator
CO686_RS01780	COG0628	permease
CO686_RS01800	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CO686_RS01815	COG1051	belongs to the nudix hydrolase family
CO686_RS01825	COG2264	protein methyltransferase activity
CO686_RS01830	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CO686_RS01835	COG1164	Oligoendopeptidase f
CO686_RS01885	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CO686_RS01900	COG0720	synthase
CO686_RS01910	COG3118	belongs to the thioredoxin family
CO686_RS01930	COG1346	cytolysis
CO686_RS01940	COG1131	(ABC) transporter
CO686_RS01945	COG1725	Transcriptional regulator
CO686_RS01960	COG1484	DNA-dependent DNA replication
CO686_RS02000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CO686_RS02005	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CO686_RS02020	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CO686_RS02030	COG3458	cephalosporin-C deacetylase activity
CO686_RS02050	COG1175	transmembrane transport
CO686_RS02055	COG0395	ABC-type sugar transport system, permease component
CO686_RS02060	COG2731	YhcH YjgK YiaL family protein
CO686_RS02070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CO686_RS02080	COG2226	methyltransferase
CO686_RS02090	COG0768	penicillin binding
CO686_RS02200	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CO686_RS02205	COG1051	belongs to the nudix hydrolase family
CO686_RS02225	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CO686_RS02245	COG3599	regulation of cell shape
CO686_RS02250	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CO686_RS02260	COG3583	domain protein
CO686_RS02260	COG3583	domain protein
CO686_RS02270	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CO686_RS02270	COG3583	domain protein
CO686_RS02290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CO686_RS02310	COG0204	Acyl-transferase
CO686_RS02315	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CO686_RS02320	COG2384	SAM-dependent methyltransferase
CO686_RS02325	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CO686_RS02330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO686_RS02335	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CO686_RS02340	COG0463	Glycosyl transferase, family 2
CO686_RS02360	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CO686_RS02380	COG0251	oxidation-reduction process
CO686_RS02390	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CO686_RS02400	COG0492	ferredoxin-NADP+ reductase activity
CO686_RS02410	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CO686_RS02430	COG1307	EDD domain protein, DegV family
CO686_RS02440	COG0617	tRNA 3'-terminal CCA addition
CO686_RS02445	COG0488	(ABC) transporter
CO686_RS02455	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CO686_RS02470	COG0463	Glycosyl transferase, family 2
CO686_RS02480	COG0242	peptide deformylase activity
CO686_RS02490	COG3022	response to hydroperoxide
CO686_RS02500	COG1846	Transcriptional regulator
CO686_RS02510	COG0436	Aminotransferase
CO686_RS02515	COG0017	Asparaginyl-tRNA synthetase
CO686_RS02520	COG0360	Binds together with S18 to 16S ribosomal RNA
CO686_RS02525	COG0629	single-stranded DNA binding
CO686_RS02530	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CO686_RS02540	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CO686_RS02555	COG1215	transferase activity, transferring glycosyl groups
CO686_RS02560	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CO686_RS02570	COG1098	S1 RNA binding domain
CO686_RS02575	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CO686_RS02580	COG2827	Endonuclease containing a URI domain
CO686_RS02605	COG3237	CsbD-like
CO686_RS02610	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CO686_RS02615	COG2244	polysaccharide biosynthetic process
CO686_RS02620	COG4166	transmembrane transport
CO686_RS02625	COG0626	cystathionine gamma-synthase activity
CO686_RS02630	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CO686_RS02635	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CO686_RS02660	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CO686_RS02670	COG1113	amino acid transport
CO686_RS02690	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CO686_RS02700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CO686_RS02705	COG0785	Cytochrome C biogenesis protein
CO686_RS02710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CO686_RS02715	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO686_RS02715	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO686_RS02720	COG4753	response regulator
CO686_RS02720	COG2207	Transcriptional regulator
CO686_RS02725	COG2972	Histidine kinase
CO686_RS02735	COG3064	Membrane
CO686_RS02745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CO686_RS02755	COG1940	carbohydrate kinase activity
CO686_RS02760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CO686_RS02780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CO686_RS02795	COG0300	oxidoreductase activity
CO686_RS02805	COG1476	TRANSCRIPTIONal
CO686_RS02815	COG3250	beta-galactosidase activity
CO686_RS02825	COG2226	methyltransferase
CO686_RS02835	COG1242	4 iron, 4 sulfur cluster binding
CO686_RS02840	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CO686_RS02850	COG0025	NhaP-type Na H and K H
CO686_RS02880	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CO686_RS02910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CO686_RS02920	COG0647	UMP catabolic process
CO686_RS02935	COG1393	Belongs to the ArsC family
CO686_RS02945	COG0483	inositol monophosphate 1-phosphatase activity
CO686_RS02950	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CO686_RS02950	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CO686_RS02955	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CO686_RS02960	COG0573	inorganic phosphate transmembrane transporter activity
CO686_RS02965	COG0581	inorganic phosphate transmembrane transporter activity
CO686_RS02970	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CO686_RS02975	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CO686_RS02980	COG0704	Plays a role in the regulation of phosphate uptake
CO686_RS02985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO686_RS02990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CO686_RS02995	COG3527	Alpha-acetolactate decarboxylase
CO686_RS03010	COG3842	ATPase activity
CO686_RS03035	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CO686_RS03045	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CO686_RS03070	COG0287	Prephenate dehydrogenase
CO686_RS03075	COG3679	Belongs to the UPF0342 family
CO686_RS03090	COG0077	Prephenate dehydratase
CO686_RS03100	COG3475	LICD family
CO686_RS03105	COG1215	transferase activity, transferring glycosyl groups
CO686_RS03110	COG3475	LICD family
CO686_RS03115	COG3475	LICD family
CO686_RS03150	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO686_RS03150	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO686_RS03155	COG1132	(ABC) transporter
CO686_RS03165	COG0402	S-adenosylhomocysteine deaminase activity
CO686_RS03175	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CO686_RS03180	COG0222	ribosome binding
CO686_RS03195	COG0270	DNA (cytosine-5-)-methyltransferase activity
CO686_RS03320	COG1396	sequence-specific DNA binding
CO686_RS03325	COG0542	response to heat
CO686_RS03360	COG3843	relaxase mobilization nuclease domain protein
CO686_RS03375	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CO686_RS03410	COG3321	synthase
CO686_RS03410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CO686_RS03410	COG1028	Short-chain dehydrogenase reductase Sdr
CO686_RS03410	COG4221	oxidoreductase activity
CO686_RS03425	COG1396	sequence-specific DNA binding
CO686_RS03440	COG4974	Belongs to the 'phage' integrase family
CO686_RS03445	COG5504	Zn-dependent protease
CO686_RS03455	COG0604	alcohol dehydrogenase
CO686_RS03475	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CO686_RS03480	COG0167	dihydroorotate dehydrogenase activity
CO686_RS03490	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CO686_RS03495	COG4470	Protein conserved in bacteria
CO686_RS03500	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CO686_RS03510	COG0488	(ABC) transporter
CO686_RS03575	COG1328	CTP reductase activity
CO686_RS03575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CO686_RS03585	COG4443	Transcriptional Coactivator p15 (PC4)
CO686_RS03595	COG1268	BioY protein
CO686_RS03600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CO686_RS03605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CO686_RS03610	COG1136	(ABC) transporter
CO686_RS03615	COG0577	efflux transmembrane transporter activity
CO686_RS03620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO686_RS03620	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO686_RS03630	COG0268	Binds directly to 16S ribosomal RNA
CO686_RS03645	COG2813	Specifically methylates the guanine in position
CO686_RS03650	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CO686_RS03660	COG0295	cytidine deaminase activity
CO686_RS03665	COG1744	ABC transporter substrate-binding protein PnrA-like
CO686_RS03670	COG3845	ABC transporter
CO686_RS03675	COG4603	Belongs to the binding-protein-dependent transport system permease family
CO686_RS03680	COG1079	Belongs to the binding-protein-dependent transport system permease family
CO686_RS03690	COG0187	DNA topoisomerase II activity
CO686_RS03715	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CO686_RS03720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CO686_RS03740	COG0539	negative regulation of cytoplasmic translation
CO686_RS03745	COG1956	GAF domain-containing protein
CO686_RS03750	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CO686_RS03765	COG0719	Fe-S assembly protein
CO686_RS03770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CO686_RS03780	COG0719	Fe-S assembly protein
CO686_RS03790	COG0531	amino acid
CO686_RS03795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CO686_RS03800	COG1307	EDD domain protein, DegV family
CO686_RS03810	COG0039	L-malate dehydrogenase activity
CO686_RS03815	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CO686_RS03820	COG3764	Sortase (surface protein transpeptidase)
CO686_RS03845	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CO686_RS03870	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CO686_RS03875	COG1438	arginine binding
CO686_RS03880	COG0497	DNA recombination
CO686_RS03885	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CO686_RS03900	COG0758	DNA mediated transformation
CO686_RS03905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CO686_RS03910	COG2832	Protein of unknown function (DUF454)
CO686_RS03915	COG3142	Participates in the control of copper homeostasis
CO686_RS03930	COG0473	3-isopropylmalate dehydrogenase activity
CO686_RS03945	COG0066	3-isopropylmalate dehydratase activity
CO686_RS03955	COG1401	restriction endodeoxyribonuclease activity
CO686_RS03980	COG1196	nuclear chromosome segregation
CO686_RS03985	COG0196	riboflavin kinase activity
CO686_RS03990	COG3689	TIGRFAM TIGR03943 family protein
CO686_RS03995	COG0701	Predicted permease
CO686_RS04005	COG2183	response to ionizing radiation
CO686_RS04030	COG0464	growth
CO686_RS04035	COG1136	(ABC) transporter
CO686_RS04040	COG0577	efflux transmembrane transporter activity
CO686_RS04050	COG0561	phosphatase activity
CO686_RS04055	COG0561	phosphatase activity
CO686_RS04060	COG0552	protein localization to endoplasmic reticulum
CO686_RS04065	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CO686_RS04070	COG1126	abc transporter atp-binding protein
CO686_RS04075	COG0765	amino acid transport
CO686_RS04135	COG1827	regulation of RNA biosynthetic process
CO686_RS04150	COG4684	Psort location CytoplasmicMembrane, score
CO686_RS04155	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CO686_RS04160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CO686_RS04195	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CO686_RS04215	COG1104	cysteine desulfurase activity
CO686_RS04220	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CO686_RS04230	COG2357	RelA SpoT domain protein
CO686_RS04240	COG0564	pseudouridine synthase activity
CO686_RS04245	COG0280	phosphate acetyltransferase
CO686_RS04250	COG1194	a g-specific adenine glycosylase
CO686_RS04255	COG0745	RESPONSE REGULATOR receiver
CO686_RS04265	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CO686_RS04275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CO686_RS04285	COG0488	(ABC) transporter
CO686_RS04295	COG2814	Major facilitator Superfamily
CO686_RS04305	COG1523	belongs to the glycosyl hydrolase 13 family
CO686_RS04310	COG1012	belongs to the aldehyde dehydrogenase family
CO686_RS04315	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CO686_RS04325	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CO686_RS04335	COG0560	Phosphoserine phosphatase
CO686_RS04385	COG1011	Hydrolase
CO686_RS04400	COG1051	belongs to the nudix hydrolase family
CO686_RS04405	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CO686_RS04410	COG0534	Mate efflux family protein
CO686_RS04415	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CO686_RS04420	COG0022	dehydrogenase e1 component
CO686_RS04425	COG0508	dehydrogenase complex catalyzes the overall conversion of
CO686_RS04430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CO686_RS04435	COG0095	Lipoate-protein ligase
CO686_RS04500	COG0038	chloride channel
CO686_RS04510	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CO686_RS04520	COG1196	nuclear chromosome segregation
CO686_RS04520	COG0745	RESPONSE REGULATOR receiver
CO686_RS04540	COG1673	EVE domain
CO686_RS04550	COG0561	phosphatase activity
CO686_RS04560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CO686_RS04580	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CO686_RS04585	COG1982	Orn Lys Arg decarboxylase major
CO686_RS04610	COG0366	Alpha amylase catalytic
CO686_RS04615	COG0135	phosphoribosylanthranilate isomerase activity
CO686_RS04620	COG1597	lipid kinase activity
CO686_RS04720	COG0488	(ABC) transporter
CO686_RS04735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CO686_RS04745	COG0741	lytic transglycosylase activity
CO686_RS04770	COG2890	protein-(glutamine-N5) methyltransferase activity
CO686_RS04785	COG1435	thymidine kinase activity
CO686_RS04790	COG1942	4-Oxalocrotonate Tautomerase
CO686_RS04795	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CO686_RS04805	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CO686_RS04815	COG4708	membrane
CO686_RS04825	COG1970	mechanosensitive ion channel activity
CO686_RS04840	COG4509	Sortase family
CO686_RS04850	COG0681	Belongs to the peptidase S26 family
CO686_RS04860	COG2195	Cleaves the N-terminal amino acid of tripeptides
CO686_RS04870	COG0803	Belongs to the bacterial solute-binding protein 9 family
CO686_RS04870	COG3443	Belongs to the bacterial solute-binding protein 9 family
CO686_RS04885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO686_RS04890	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CO686_RS04895	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CO686_RS04900	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CO686_RS04920	COG3684	Belongs to the aldolase LacD family
CO686_RS04945	COG3775	system Galactitol-specific IIC component
CO686_RS04960	COG4750	Nucleotidyl transferase
CO686_RS04975	COG1063	alcohol dehydrogenase
CO686_RS04990	COG0584	glycerophosphoryl diester phosphodiesterase
CO686_RS05015	COG0494	nUDIX hydrolase
CO686_RS05020	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CO686_RS05035	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CO686_RS05055	COG1126	abc transporter atp-binding protein
CO686_RS05070	COG0628	permease
CO686_RS05075	COG2706	6-phosphogluconolactonase activity
CO686_RS05105	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CO686_RS05110	COG0356	it plays a direct role in the translocation of protons across the membrane
CO686_RS05125	COG0826	peptidase U32
CO686_RS05130	COG2188	Transcriptional regulator
CO686_RS05190	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CO686_RS05205	COG0628	permease
CO686_RS05210	COG1686	Belongs to the peptidase S11 family
CO686_RS05215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CO686_RS05220	COG0785	Cytochrome C biogenesis protein
CO686_RS05225	COG0024	Methionine aminopeptidase
CO686_RS05230	COG4109	DRTGG domain
CO686_RS05240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CO686_RS05245	COG0469	pyruvate kinase activity
CO686_RS05260	COG2936	dipeptidyl-peptidase activity
CO686_RS05265	COG1438	arginine binding
CO686_RS05290	COG0438	transferase activity, transferring glycosyl groups
CO686_RS05295	COG0438	transferase activity, transferring glycosyl groups
CO686_RS05300	COG2151	metal-sulfur cluster biosynthetic enzyme
CO686_RS05305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CO686_RS05310	COG0358	DNA primase activity
CO686_RS05315	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CO686_RS05330	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CO686_RS05335	COG0772	Belongs to the SEDS family
CO686_RS05345	COG4122	O-methyltransferase activity
CO686_RS05365	COG0500	methyltransferase
CO686_RS05365	COG3615	Tellurite resistance protein tehB
CO686_RS05375	COG0557	exoribonuclease II activity
CO686_RS05385	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CO686_RS05390	COG2814	Major facilitator Superfamily
CO686_RS05395	COG0237	dephospho-CoA kinase activity
CO686_RS05400	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CO686_RS05410	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CO686_RS05420	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CO686_RS05425	COG0813	purine-nucleoside phosphorylase activity
CO686_RS05435	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CO686_RS05460	COG1136	(ABC) transporter
CO686_RS05475	COG5002	protein histidine kinase activity
CO686_RS05480	COG0745	RESPONSE REGULATOR receiver
CO686_RS05505	COG1028	Short-chain dehydrogenase reductase Sdr
CO686_RS05520	COG4193	domain, Protein
CO686_RS05520	COG5263	repeat protein
CO686_RS05525	COG0167	dihydroorotate dehydrogenase activity
CO686_RS05530	COG0543	2 iron, 2 sulfur cluster binding
CO686_RS05545	COG0443	Heat shock 70 kDa protein
CO686_RS05550	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CO686_RS05555	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CO686_RS05565	COG2333	competence protein COMEC
CO686_RS05565	COG0658	competence protein
CO686_RS05570	COG1555	photosystem II stabilization
CO686_RS05570	COG1596	polysaccharide export
CO686_RS05575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CO686_RS05580	COG0686	Belongs to the AlaDH PNT family
CO686_RS05585	COG3583	domain protein
CO686_RS05585	COG4932	domain protein
CO686_RS05585	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CO686_RS05600	COG1702	phosphate starvation-inducible protein PhoH
CO686_RS05610	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CO686_RS05610	COG0456	acetyltransferase
CO686_RS05615	COG2996	Protein conserved in bacteria
CO686_RS05625	COG0528	UMP kinase activity
CO686_RS05645	COG0470	DNA polymerase III
CO686_RS05655	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CO686_RS05670	COG0564	pseudouridine synthase activity
CO686_RS05675	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CO686_RS05680	COG0583	DNA-binding transcription factor activity
CO686_RS05720	COG1078	dGTPase activity
CO686_RS05825	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CO686_RS05830	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CO686_RS05835	COG1605	Chorismate mutase
CO686_RS05835	COG0077	Prephenate dehydratase
CO686_RS05840	COG0716	FMN binding
CO686_RS05845	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CO686_RS05860	COG1914	H( )-stimulated, divalent metal cation uptake system
CO686_RS05870	COG0505	Belongs to the CarA family
CO686_RS05885	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CO686_RS05900	COG0488	(ABC) transporter
CO686_RS05910	COG1704	LemA family
CO686_RS05930	COG0697	spore germination
CO686_RS05935	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CO686_RS05945	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CO686_RS05970	COG1104	cysteine desulfurase activity
CO686_RS05980	COG0697	spore germination
CO686_RS05980	COG1674	ftsk spoiiie
CO686_RS05985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CO686_RS05985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CO686_RS05985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO686_RS05990	COG1105	Belongs to the carbohydrate kinase PfkB family
CO686_RS05995	COG1349	DNA-binding transcription factor activity
CO686_RS06025	COG0561	phosphatase activity
CO686_RS06045	COG0492	ferredoxin-NADP+ reductase activity
CO686_RS06055	COG1126	abc transporter atp-binding protein
CO686_RS06065	COG1393	Belongs to the ArsC family
CO686_RS06085	COG1272	protein, Hemolysin III
CO686_RS06115	COG1053	succinate dehydrogenase
CO686_RS06115	COG0431	NADPH-dependent FMN reductase
CO686_RS06115	COG3976	FMN-binding domain protein
CO686_RS06145	COG0656	L-ascorbic acid biosynthetic process
CO686_RS06150	COG0726	polysaccharide deacetylase
CO686_RS06160	COG0187	DNA topoisomerase II activity
CO686_RS06170	COG0366	Alpha amylase catalytic
CO686_RS06170	COG5263	repeat protein
CO686_RS06175	COG1396	sequence-specific DNA binding
CO686_RS06185	COG0772	Belongs to the SEDS family
CO686_RS06190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CO686_RS06190	COG1199	ATP-dependent helicase activity
CO686_RS06195	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CO686_RS06205	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CO686_RS06215	COG1126	abc transporter atp-binding protein
CO686_RS06220	COG0765	amino acid transport
CO686_RS06225	COG4703	Protein of unknown function (DUF1797)
CO686_RS06230	COG0542	response to heat
CO686_RS06240	COG2378	regulation of single-species biofilm formation
CO686_RS06270	COG0513	Belongs to the DEAD box helicase family
CO686_RS06280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO686_RS06280	COG2190	(PTS) system
CO686_RS06280	COG1263	PTS System
CO686_RS06285	COG2177	Part of the ABC transporter FtsEX involved in
CO686_RS06290	COG2884	Cell division ATP-binding protein ftsE
CO686_RS06305	COG0617	tRNA 3'-terminal CCA addition
CO686_RS06305	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CO686_RS06305	COG0517	IMP dehydrogenase activity
CO686_RS06340	COG0740	serine-type endopeptidase activity
CO686_RS06345	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CO686_RS06350	COG2131	deaminase
CO686_RS06360	COG1307	EDD domain protein, DegV family
CO686_RS06365	COG2081	HI0933 family
CO686_RS06375	COG0789	Transcriptional regulator
CO686_RS06380	COG0733	neurotransmitter:sodium symporter activity
CO686_RS06385	COG1482	cell wall glycoprotein biosynthetic process
CO686_RS06415	COG0028	Belongs to the TPP enzyme family
CO686_RS06420	COG2217	Heavy metal translocating P-type atpase
CO686_RS06440	COG0352	thiamine-phosphate diphosphorylase activity
CO686_RS06455	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CO686_RS06465	COG4172	Belongs to the ABC transporter superfamily
CO686_RS06480	COG1304	FMN binding
CO686_RS06510	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CO686_RS06525	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CO686_RS06545	COG1217	gtp-binding protein TYPA
CO686_RS06550	COG1187	pseudouridine synthase activity
CO686_RS06570	COG0583	DNA-binding transcription factor activity
CO686_RS06595	COG1404	Belongs to the peptidase S8 family
CO686_RS06610	COG4555	ABC transporter
CO686_RS06625	COG0191	fructose-bisphosphate aldolase activity
CO686_RS06630	COG5002	protein histidine kinase activity
CO686_RS06635	COG0745	RESPONSE REGULATOR receiver
CO686_RS06640	COG0577	efflux transmembrane transporter activity
CO686_RS06645	COG1136	(ABC) transporter
CO686_RS06650	COG0577	efflux transmembrane transporter activity
CO686_RS06660	COG1335	isochorismatase
CO686_RS06665	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CO686_RS06670	COG0513	Belongs to the DEAD box helicase family
CO686_RS06675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CO686_RS06680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CO686_RS06685	COG3442	glutamine amidotransferase
CO686_RS06690	COG0006	proline dipeptidase activity
CO686_RS06695	COG4720	Psort location CytoplasmicMembrane, score
CO686_RS06700	COG0351	phosphomethylpyrimidine kinase
CO686_RS06720	COG2824	Alkylphosphonate utilization operon protein PhnA
CO686_RS06730	COG0149	triose-phosphate isomerase activity
CO686_RS06735	COG3935	DnaD domain protein
CO686_RS06745	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CO686_RS06770	COG1363	Peptidase, m42
CO686_RS06780	COG1114	Component of the transport system for branched-chain amino acids
CO686_RS06785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CO686_RS06790	COG1573	uracil-dna glycosylase
CO686_RS06840	COG0322	excinuclease ABC activity
CO686_RS06860	COG3942	CHAP domain
CO686_RS06865	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CO686_RS06865	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CO686_RS06875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO686_RS06880	COG0765	amino acid transport
CO686_RS06885	COG0765	amino acid transport
CO686_RS06895	COG1959	2 iron, 2 sulfur cluster binding
CO686_RS06920	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CO686_RS06930	COG0745	RESPONSE REGULATOR receiver
CO686_RS06955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CO686_RS06965	COG3590	peptidase
CO686_RS06985	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CO686_RS07010	COG3842	ATPase activity
CO686_RS07020	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CO686_RS07025	COG0215	cysteine-tRNA ligase activity
CO686_RS07045	COG1045	serine acetyltransferase
CO686_RS07060	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CO686_RS07065	COG3620	sequence-specific DNA binding
CO686_RS07070	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
CO686_RS07115	COG5290	Psort location Cytoplasmic, score
CO686_RS07130	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CO686_RS07145	COG1940	carbohydrate kinase activity
CO686_RS07150	COG2190	(PTS) system
CO686_RS07150	COG1263	PTS System
CO686_RS07150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO686_RS07155	COG1621	beta-fructofuranosidase activity
CO686_RS07160	COG1609	Transcriptional regulator
CO686_RS07175	COG3425	synthase
CO686_RS07190	COG0515	serine threonine protein kinase
CO686_RS07190	COG2815	serine threonine protein kinase
CO686_RS07195	COG0631	protein serine/threonine phosphatase activity
CO686_RS07200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CO686_RS07200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CO686_RS07210	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CO686_RS07220	COG0194	GDP metabolic process
CO686_RS07255	COG2226	methyltransferase
CO686_RS07265	COG0799	negative regulation of ribosome biogenesis
CO686_RS07270	COG1713	HD superfamily hydrolase involved in NAD metabolism
CO686_RS07275	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CO686_RS07280	COG1534	Rna-binding protein
CO686_RS07285	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CO686_RS07290	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CO686_RS07300	COG0668	transmembrane transport
CO686_RS07305	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CO686_RS07335	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CO686_RS07395	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CO686_RS07400	COG0439	Biotin carboxylase
CO686_RS07415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CO686_RS07420	COG1028	Short-chain dehydrogenase reductase Sdr
CO686_RS07425	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CO686_RS07435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CO686_RS07445	COG1846	Transcriptional regulator
CO686_RS07450	COG1024	Enoyl-CoA hydratase
CO686_RS07455	COG0527	aspartate kinase activity
CO686_RS07485	COG1115	amino acid carrier protein
CO686_RS07510	COG0681	Belongs to the peptidase S26 family
CO686_RS07515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CO686_RS07520	COG0544	peptidyl-prolyl cis-trans isomerase activity
CO686_RS07530	COG2197	response regulator
CO686_RS07535	COG4585	Histidine kinase
CO686_RS07560	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CO686_RS07570	COG0745	RESPONSE REGULATOR receiver
CO686_RS07575	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CO686_RS07585	COG0116	Belongs to the methyltransferase superfamily
CO686_RS07630	COG0366	Alpha amylase catalytic
CO686_RS07635	COG1091	dTDP-4-dehydrorhamnose reductase activity
CO686_RS07640	COG1088	dTDP-glucose 4,6-dehydratase activity
CO686_RS07655	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CO686_RS07660	COG0438	transferase activity, transferring glycosyl groups
CO686_RS07665	COG0562	UDP-galactopyranose mutase
CO686_RS07680	COG1442	glycosyl transferase family 8
CO686_RS07680	COG1216	Glycosyl transferase, family 2
CO686_RS07690	COG0297	glycogen (starch) synthase activity
CO686_RS07705	COG0489	protein tyrosine kinase activity
CO686_RS07710	COG3944	biosynthesis protein
CO686_RS07715	COG4464	protein tyrosine phosphatase activity
CO686_RS07725	COG4166	transmembrane transport
CO686_RS07730	COG4166	transmembrane transport
CO686_RS07735	COG0366	Alpha amylase catalytic
CO686_RS07755	COG1882	Formate acetyltransferase
CO686_RS07760	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CO686_RS07775	COG0765	amino acid transport
CO686_RS07780	COG1126	abc transporter atp-binding protein
CO686_RS07795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CO686_RS07805	COG0440	acetolactate synthase activity
CO686_RS07810	COG0028	Belongs to the TPP enzyme family
CO686_RS07835	COG2197	response regulator
CO686_RS07840	COG4585	Histidine kinase
CO686_RS07850	COG1131	(ABC) transporter
CO686_RS07870	COG1461	Dihydroxyacetone kinase
CO686_RS07880	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CO686_RS07905	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CO686_RS07950	COG0534	Mate efflux family protein
CO686_RS07975	COG1316	TRANSCRIPTIONal
CO686_RS07985	COG0802	atpase or kinase
CO686_RS08010	COG1523	belongs to the glycosyl hydrolase 13 family
CO686_RS08020	COG1126	abc transporter atp-binding protein
CO686_RS08025	COG0765	amino acid transport
CO686_RS08030	COG0765	amino acid transport
CO686_RS08035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO686_RS08055	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CO686_RS08065	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CO686_RS08075	COG2723	6-phospho-beta-galactosidase activity
CO686_RS08085	COG0750	zinc metalloprotease
CO686_RS08090	COG4589	Belongs to the CDS family
CO686_RS08095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CO686_RS08105	COG2255	four-way junction helicase activity
CO686_RS08130	COG0588	phosphoglycerate mutase activity
CO686_RS08135	COG2848	UPF0210 protein
CO686_RS08140	COG3830	Belongs to the UPF0237 family
CO686_RS08150	COG0202	RNA polymerase activity
CO686_RS08155	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CO686_RS08165	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CO686_RS08170	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CO686_RS08180	COG0201	protein transport
CO686_RS08195	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CO686_RS08215	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CO686_RS08235	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CO686_RS08260	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CO686_RS08295	COG0602	queuosine metabolic process
CO686_RS08310	COG1328	CTP reductase activity
CO686_RS08320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CO686_RS08325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CO686_RS08335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CO686_RS08340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CO686_RS08350	COG1454	alcohol dehydrogenase
CO686_RS08360	COG0285	dihydrofolate synthase activity
CO686_RS08385	COG1393	Belongs to the ArsC family
CO686_RS08390	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CO686_RS08395	COG0006	proline dipeptidase activity
CO686_RS08405	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CO686_RS08435	COG2818	Glycosylase
CO686_RS08445	COG1395	domain, Protein
CO686_RS08470	COG1438	arginine binding
CO686_RS08490	COG1780	Probably involved in ribonucleotide reductase function
CO686_RS08500	COG4753	response regulator
CO686_RS08500	COG2207	Transcriptional regulator
CO686_RS08505	COG2972	Histidine kinase
CO686_RS08525	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CO686_RS08530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CO686_RS08535	COG1464	Belongs to the NlpA lipoprotein family
CO686_RS08540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO686_RS08570	COG1214	PFAM Peptidase M22, glycoprotease
CO686_RS08600	COG0445	tRNA wobble uridine modification
CO686_RS08605	COG0494	nUDIX hydrolase
CO686_RS08610	COG0494	nUDIX hydrolase
CO686_RS08630	COG0137	argininosuccinate synthase activity
CO686_RS08635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO686_RS08645	COG1760	l-serine dehydratase
CO686_RS08650	COG1760	l-serine dehydratase
CO686_RS08655	COG0546	phosphoglycolate phosphatase activity
CO686_RS08665	COG1216	Glycosyl transferase, family 2
CO686_RS08670	COG2807	transmembrane transport
CO686_RS08715	COG1653	transport
CO686_RS08720	COG0395	ABC-type sugar transport system, permease component
CO686_RS08725	COG4209	transmembrane transport
CO686_RS08740	COG0383	alpha-mannosidase activity
CO686_RS08750	COG3537	Alpha-1,2-mannosidase
CO686_RS08760	COG0803	Belongs to the bacterial solute-binding protein 9 family
CO686_RS08760	COG3443	Belongs to the bacterial solute-binding protein 9 family
CO686_RS08765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CO686_RS08770	COG1121	(ABC) transporter
CO686_RS08775	COG1846	Transcriptional regulator
CO686_RS08780	COG0737	Belongs to the 5'-nucleotidase family
CO686_RS08785	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CO686_RS08790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CO686_RS08795	COG1696	Membrane protein involved in D-alanine export
CO686_RS08810	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CO686_RS08815	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CO686_RS08835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CO686_RS08855	COG3201	nicotinamide mononucleotide transporter
CO686_RS08865	COG0542	response to heat
CO686_RS08870	COG4463	regulation of RNA biosynthetic process
CO686_RS08875	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CO686_RS08880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CO686_RS08885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CO686_RS08895	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CO686_RS08895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CO686_RS08900	COG3942	CHAP domain
CO686_RS08910	COG0305	Participates in initiation and elongation during chromosome replication
CO686_RS08925	COG2070	2-Nitropropane dioxygenase
CO686_RS08935	COG1960	acyl-CoA dehydrogenase activity
CO686_RS08940	COG0583	DNA-binding transcription factor activity
CO686_RS08945	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CO686_RS08950	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CO686_RS08955	COG1024	Enoyl-CoA hydratase
CO686_RS08965	COG1250	3-hydroxyacyl-CoA dehydrogenase
CO686_RS08970	COG1960	acyl-CoA dehydrogenase activity
CO686_RS08980	COG1040	competence protein
CO686_RS08985	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CO686_RS08990	COG1739	Uncharacterized protein family UPF0029
CO686_RS09015	COG3942	CHAP domain
CO686_RS09025	COG1792	Involved in formation and maintenance of cell shape
CO686_RS09030	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CO686_RS09035	COG1122	ATPase activity
CO686_RS09040	COG1122	ATPase activity
CO686_RS09045	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CO686_RS09055	COG0612	Peptidase, M16
CO686_RS09060	COG0612	Peptidase, M16
CO686_RS09065	COG2501	S4 domain
CO686_RS09075	COG0517	IMP dehydrogenase activity
CO686_RS09075	COG0516	GMP reductase activity
CO686_RS09080	COG0180	Tryptophanyl-tRNA synthetase
CO686_RS09085	COG0488	(ABC) transporter
CO686_RS09095	COG1511	domain protein
CO686_RS09095	COG1511	domain protein
CO686_RS09140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CO686_RS09145	COG1475	DNA binding
CO686_RS09155	COG0592	DNA-directed DNA polymerase activity
CO686_RS09165	COG0012	GTP binding
CO686_RS09175	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CO686_RS09180	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CO686_RS09200	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CO686_RS09205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CO686_RS09210	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CO686_RS09270	COG0756	dUTP diphosphatase activity
CO686_RS09280	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CO686_RS09290	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CO686_RS09295	COG1832	CoA-binding protein
CO686_RS09300	COG2855	membrane
CO686_RS09305	COG0436	Aminotransferase
CO686_RS09320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CO686_RS09350	COG2274	protein secretion by the type I secretion system
CO686_RS09355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CO686_RS09365	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CO686_RS09375	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CO686_RS09380	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CO686_RS09390	COG0138	bifunctional purine biosynthesis protein purh
CO686_RS09410	COG0151	Belongs to the GarS family
CO686_RS09415	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CO686_RS09430	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CO686_RS09435	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CO686_RS09435	COG3583	domain protein
CO686_RS09435	COG3064	Membrane
CO686_RS09450	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO686_RS09455	COG3715	PTS system
CO686_RS09460	COG3716	PTS system mannose fructose sorbose family IID component
CO686_RS09475	COG2222	sugar isomerase
CO686_RS09480	COG3684	Belongs to the aldolase LacD family
CO686_RS09490	COG2514	catechol 2,3-dioxygenase activity
CO686_RS09520	COG1937	Protein conserved in bacteria
CO686_RS09525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CO686_RS09535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CO686_RS09535	COG0425	Belongs to the sulfur carrier protein TusA family
CO686_RS09540	COG0110	maltose O-acetyltransferase activity
CO686_RS09565	COG1309	transcriptional regulator
CO686_RS09580	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CO686_RS09595	COG0745	RESPONSE REGULATOR receiver
CO686_RS09600	COG5002	protein histidine kinase activity
CO686_RS09610	COG0582	viral genome integration into host DNA
CO686_RS09780	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CO686_RS09795	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CO686_RS09815	COG2151	metal-sulfur cluster biosynthetic enzyme
CO686_RS09820	COG0124	histidyl-tRNA synthetase
CO686_RS09840	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CO686_RS09845	COG1609	Transcriptional regulator
CO686_RS09850	COG5521	maltodextrose utilization protein MalA
CO686_RS09860	COG3833	ABC-type maltose transport systems, permease component
CO686_RS09865	COG1175	transmembrane transport
CO686_RS09870	COG2182	Extracellular solute-binding protein
CO686_RS09875	COG1640	4-alpha-glucanotransferase
CO686_RS09880	COG0058	SHG alpha-glucan phosphorylase activity
CO686_RS09890	COG2226	methyltransferase
CO686_RS09900	COG2217	Heavy metal translocating P-type atpase
CO686_RS09910	COG4499	WXG100 protein secretion system (Wss), protein YukC
CO686_RS09910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CO686_RS09915	COG0697	spore germination
CO686_RS09930	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CO686_RS09945	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CO686_RS09950	COG1518	maintenance of DNA repeat elements
CO686_RS09955	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
CO686_RS09960	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CO686_RS09970	COG1132	(ABC) transporter
CO686_RS09975	COG1132	(ABC) transporter
CO686_RS09980	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CO686_RS09990	COG0166	Belongs to the GPI family
CO686_RS10145	COG0534	Mate efflux family protein
CO686_RS10150	COG0546	phosphoglycolate phosphatase activity
CO686_RS10185	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CO686_RS10195	COG4537	Required for transformation and DNA binding