locus-tag	class	description
I6G42_RS00105	COG2274	protein secretion by the type I secretion system
I6G42_RS00110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G42_RS00120	COG3290	protein histidine kinase activity
I6G42_RS00145	COG1131	(ABC) transporter
I6G42_RS00150	COG0537	adenosine 5'-monophosphoramidase activity
I6G42_RS00165	COG0484	heat shock protein binding
I6G42_RS00175	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6G42_RS00200	COG0174	glutamine synthetase
I6G42_RS00205	COG0789	Transcriptional regulator
I6G42_RS00215	COG0126	phosphoglycerate kinase activity
I6G42_RS00220	COG2378	regulation of single-species biofilm formation
I6G42_RS00230	COG0366	Alpha amylase catalytic
I6G42_RS00245	COG1363	Peptidase, m42
I6G42_RS00250	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G42_RS00255	COG4605	iron ion homeostasis
I6G42_RS00260	COG4604	ABC transporter, ATP-binding protein
I6G42_RS00265	COG4607	ABC-type enterochelin transport system periplasmic component
I6G42_RS00275	COG1187	pseudouridine synthase activity
I6G42_RS00295	COG0517	IMP dehydrogenase activity
I6G42_RS00320	COG0366	Alpha amylase catalytic
I6G42_RS00330	COG0768	penicillin binding
I6G42_RS00335	COG4839	cell division protein FtsL
I6G42_RS00360	COG0386	Belongs to the glutathione peroxidase family
I6G42_RS00365	COG0366	Alpha amylase catalytic
I6G42_RS00375	COG1216	Glycosyl transferase, family 2
I6G42_RS00435	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6G42_RS00440	COG1668	transmembrane transport
I6G42_RS00445	COG4152	abc transporter atp-binding protein
I6G42_RS00450	COG0072	phenylalanine-tRNA ligase activity
I6G42_RS00450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G42_RS00470	COG0671	phosphoesterase, PA-phosphatase related
I6G42_RS00475	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I6G42_RS00485	COG0569	domain protein
I6G42_RS00490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G42_RS00495	COG4608	Belongs to the ABC transporter superfamily
I6G42_RS00500	COG0444	Belongs to the ABC transporter superfamily
I6G42_RS00505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G42_RS00510	COG0601	transmembrane transport
I6G42_RS00515	COG4166	transmembrane transport
I6G42_RS00525	COG1253	flavin adenine dinucleotide binding
I6G42_RS00540	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6G42_RS00550	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6G42_RS00555	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6G42_RS00560	COG0742	ribosomal rna small subunit methyltransferase
I6G42_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G42_RS00580	COG1254	Belongs to the acylphosphatase family
I6G42_RS00590	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G42_RS00600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G42_RS00605	COG3481	metal-dependent phosphohydrolase, HD sub domain
I6G42_RS00615	COG1564	THIamine pyrophosphokinase
I6G42_RS00625	COG1162	GTPase activity
I6G42_RS00630	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6G42_RS00650	COG0084	hydrolase, TatD family'
I6G42_RS00655	COG0531	amino acid
I6G42_RS00660	COG4166	transmembrane transport
I6G42_RS00670	COG0436	Aminotransferase
I6G42_RS00680	COG0589	response to stress
I6G42_RS00685	COG0561	phosphatase activity
I6G42_RS00690	COG0252	asparaginase activity
I6G42_RS00695	COG1609	Transcriptional regulator
I6G42_RS00705	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6G42_RS00705	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6G42_RS00715	COG0285	dihydrofolate synthase activity
I6G42_RS00720	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6G42_RS00725	COG1266	CAAX protease self-immunity
I6G42_RS00730	COG2252	PERMEase
I6G42_RS00735	COG0561	phosphatase activity
I6G42_RS00745	COG3715	PTS system
I6G42_RS00750	COG3716	PTS system mannose fructose sorbose family IID component
I6G42_RS00755	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6G42_RS00760	COG3579	cysteine-type endopeptidase activity
I6G42_RS00765	COG1187	pseudouridine synthase activity
I6G42_RS00770	COG2261	transglycosylase associated protein
I6G42_RS00775	COG2309	aminopeptidase activity
I6G42_RS00785	COG2176	DNA-directed DNA polymerase activity
I6G42_RS00790	COG2723	6-phospho-beta-galactosidase activity
I6G42_RS00800	COG0750	zinc metalloprotease
I6G42_RS00805	COG4589	Belongs to the CDS family
I6G42_RS00810	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6G42_RS00815	COG1126	abc transporter atp-binding protein
I6G42_RS00820	COG0765	amino acid transport
I6G42_RS00825	COG0765	amino acid transport
I6G42_RS00830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G42_RS00855	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6G42_RS00895	COG0588	phosphoglycerate mutase activity
I6G42_RS00900	COG2848	UPF0210 protein
I6G42_RS00905	COG3830	Belongs to the UPF0237 family
I6G42_RS00915	COG0202	RNA polymerase activity
I6G42_RS00920	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6G42_RS00930	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G42_RS00935	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6G42_RS00945	COG0201	protein transport
I6G42_RS00960	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6G42_RS00985	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6G42_RS01005	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6G42_RS01015	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6G42_RS01030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6G42_RS01080	COG1328	CTP reductase activity
I6G42_RS01095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G42_RS01100	COG1454	alcohol dehydrogenase
I6G42_RS01110	COG0285	dihydrofolate synthase activity
I6G42_RS01135	COG1393	Belongs to the ArsC family
I6G42_RS01140	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6G42_RS01145	COG0006	proline dipeptidase activity
I6G42_RS01150	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6G42_RS01175	COG2818	Glycosylase
I6G42_RS01185	COG1395	domain, Protein
I6G42_RS01210	COG1438	arginine binding
I6G42_RS01230	COG1780	Probably involved in ribonucleotide reductase function
I6G42_RS01240	COG4753	response regulator
I6G42_RS01240	COG2207	Transcriptional regulator
I6G42_RS01245	COG2972	Histidine kinase
I6G42_RS01265	COG1696	Membrane protein involved in D-alanine export
I6G42_RS01275	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G42_RS01280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G42_RS01285	COG1464	Belongs to the NlpA lipoprotein family
I6G42_RS01290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G42_RS01330	COG1396	sequence-specific DNA binding
I6G42_RS01345	COG1214	PFAM Peptidase M22, glycoprotease
I6G42_RS01365	COG0445	tRNA wobble uridine modification
I6G42_RS01370	COG0494	nUDIX hydrolase
I6G42_RS01385	COG0137	argininosuccinate synthase activity
I6G42_RS01390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G42_RS01395	COG0577	efflux transmembrane transporter activity
I6G42_RS01395	COG1136	(ABC) transporter
I6G42_RS01410	COG3584	3D domain protein
I6G42_RS01410	COG1388	LysM domain
I6G42_RS01415	COG1760	l-serine dehydratase
I6G42_RS01420	COG1760	l-serine dehydratase
I6G42_RS01425	COG0546	phosphoglycolate phosphatase activity
I6G42_RS01435	COG1216	Glycosyl transferase, family 2
I6G42_RS01440	COG2807	transmembrane transport
I6G42_RS01470	COG1136	(ABC) transporter
I6G42_RS01485	COG1131	(ABC) transporter
I6G42_RS01535	COG1653	transport
I6G42_RS01540	COG0395	ABC-type sugar transport system, permease component
I6G42_RS01545	COG4209	transmembrane transport
I6G42_RS01565	COG0383	alpha-mannosidase activity
I6G42_RS01575	COG3537	Alpha-1,2-mannosidase
I6G42_RS01595	COG0549	Belongs to the carbamate kinase family
I6G42_RS01600	COG1288	antiporter activity
I6G42_RS01605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G42_RS01610	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6G42_RS01610	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6G42_RS01615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G42_RS01620	COG1121	(ABC) transporter
I6G42_RS01625	COG1846	Transcriptional regulator
I6G42_RS01630	COG0737	Belongs to the 5'-nucleotidase family
I6G42_RS01635	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6G42_RS01645	COG1696	Membrane protein involved in D-alanine export
I6G42_RS01660	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G42_RS01665	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6G42_RS01685	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G42_RS01720	COG0542	response to heat
I6G42_RS01725	COG4463	regulation of RNA biosynthetic process
I6G42_RS01745	COG1116	anion transmembrane transporter activity
I6G42_RS01750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G42_RS01755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G42_RS01765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G42_RS01765	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G42_RS01770	COG3942	CHAP domain
I6G42_RS01780	COG0305	Participates in initiation and elongation during chromosome replication
I6G42_RS01805	COG1040	competence protein
I6G42_RS01810	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6G42_RS01815	COG1739	Uncharacterized protein family UPF0029
I6G42_RS01835	COG3942	CHAP domain
I6G42_RS01845	COG1792	Involved in formation and maintenance of cell shape
I6G42_RS01850	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6G42_RS01855	COG1122	ATPase activity
I6G42_RS01860	COG1122	ATPase activity
I6G42_RS01865	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6G42_RS01875	COG0612	Peptidase, M16
I6G42_RS01880	COG0612	Peptidase, M16
I6G42_RS01895	COG0517	IMP dehydrogenase activity
I6G42_RS01895	COG0516	GMP reductase activity
I6G42_RS01900	COG0180	Tryptophanyl-tRNA synthetase
I6G42_RS01905	COG0488	(ABC) transporter
I6G42_RS01915	COG1511	domain protein
I6G42_RS01915	COG1511	domain protein
I6G42_RS01960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G42_RS01965	COG1475	DNA binding
I6G42_RS01975	COG0592	DNA-directed DNA polymerase activity
I6G42_RS01985	COG0012	GTP binding
I6G42_RS01995	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6G42_RS02000	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6G42_RS02020	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6G42_RS02025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G42_RS02070	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6G42_RS02200	COG0582	viral genome integration into host DNA
I6G42_RS02330	COG0756	dUTP diphosphatase activity
I6G42_RS02340	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6G42_RS02350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6G42_RS02355	COG1832	CoA-binding protein
I6G42_RS02360	COG2855	membrane
I6G42_RS02365	COG0436	Aminotransferase
I6G42_RS02380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G42_RS02405	COG2274	protein secretion by the type I secretion system
I6G42_RS02410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G42_RS02420	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6G42_RS02430	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6G42_RS02435	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6G42_RS02440	COG0138	bifunctional purine biosynthesis protein purh
I6G42_RS02455	COG0151	Belongs to the GarS family
I6G42_RS02460	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6G42_RS02480	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6G42_RS02485	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6G42_RS02485	COG3583	domain protein
I6G42_RS02485	COG3064	Membrane
I6G42_RS02500	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G42_RS02505	COG3715	PTS system
I6G42_RS02510	COG3716	PTS system mannose fructose sorbose family IID component
I6G42_RS02520	COG2222	sugar isomerase
I6G42_RS02525	COG3684	Belongs to the aldolase LacD family
I6G42_RS02570	COG0745	RESPONSE REGULATOR receiver
I6G42_RS02575	COG2357	RelA SpoT domain protein
I6G42_RS02580	COG1937	Protein conserved in bacteria
I6G42_RS02600	COG0425	Belongs to the sulfur carrier protein TusA family
I6G42_RS02600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G42_RS02605	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G42_RS02610	COG0425	Belongs to the sulfur carrier protein TusA family
I6G42_RS02610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G42_RS02615	COG0110	maltose O-acetyltransferase activity
I6G42_RS02630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G42_RS02645	COG0745	RESPONSE REGULATOR receiver
I6G42_RS02650	COG5002	protein histidine kinase activity
I6G42_RS02740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G42_RS02755	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6G42_RS02780	COG2151	metal-sulfur cluster biosynthetic enzyme
I6G42_RS02795	COG0124	histidyl-tRNA synthetase
I6G42_RS02805	COG1476	TRANSCRIPTIONal
I6G42_RS02855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G42_RS02865	COG4842	Belongs to the WXG100 family
I6G42_RS02880	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6G42_RS02885	COG1674	ftsk spoiiie
I6G42_RS02995	COG2801	Transposase and inactivated derivatives
I6G42_RS03000	COG1609	Transcriptional regulator
I6G42_RS03005	COG5521	maltodextrose utilization protein MalA
I6G42_RS03010	COG3833	ABC-type maltose transport systems, permease component
I6G42_RS03015	COG1175	transmembrane transport
I6G42_RS03020	COG2182	Extracellular solute-binding protein
I6G42_RS03025	COG1640	4-alpha-glucanotransferase
I6G42_RS03030	COG0058	SHG alpha-glucan phosphorylase activity
I6G42_RS03045	COG2217	Heavy metal translocating P-type atpase
I6G42_RS03060	COG0697	spore germination
I6G42_RS03075	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6G42_RS03085	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G42_RS03095	COG1132	(ABC) transporter
I6G42_RS03100	COG1132	(ABC) transporter
I6G42_RS03105	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6G42_RS03110	COG0166	Belongs to the GPI family
I6G42_RS03130	COG3730	PTS system glucitol sorbitol-specific
I6G42_RS03135	COG3732	PTS system glucitol sorbitol-specific
I6G42_RS03255	COG0534	Mate efflux family protein
I6G42_RS03260	COG0546	phosphoglycolate phosphatase activity
I6G42_RS03275	COG1846	Transcriptional regulator
I6G42_RS03280	COG3759	membrane
I6G42_RS03310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G42_RS03315	COG1459	type II secretion system
I6G42_RS03320	COG4537	Required for transformation and DNA binding
I6G42_RS03345	COG2264	protein methyltransferase activity
I6G42_RS03365	COG0706	membrane insertase activity
I6G42_RS03380	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6G42_RS03390	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G42_RS03400	COG1454	alcohol dehydrogenase
I6G42_RS03400	COG1012	belongs to the aldehyde dehydrogenase family
I6G42_RS03415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G42_RS03420	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6G42_RS03515	COG1523	belongs to the glycosyl hydrolase 13 family
I6G42_RS03535	COG0802	atpase or kinase
I6G42_RS03545	COG1316	TRANSCRIPTIONal
I6G42_RS03565	COG0534	Mate efflux family protein
I6G42_RS03615	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6G42_RS03625	COG1461	Dihydroxyacetone kinase
I6G42_RS03640	COG1131	(ABC) transporter
I6G42_RS03650	COG4585	Histidine kinase
I6G42_RS03655	COG2197	response regulator
I6G42_RS03675	COG0028	Belongs to the TPP enzyme family
I6G42_RS03680	COG0440	acetolactate synthase activity
I6G42_RS03690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G42_RS03710	COG0765	amino acid transport
I6G42_RS03725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G42_RS03730	COG1882	Formate acetyltransferase
I6G42_RS03745	COG1131	(ABC) transporter
I6G42_RS03775	COG0366	Alpha amylase catalytic
I6G42_RS03780	COG4166	transmembrane transport
I6G42_RS03785	COG4166	transmembrane transport
I6G42_RS03795	COG4464	protein tyrosine phosphatase activity
I6G42_RS03800	COG3944	biosynthesis protein
I6G42_RS03805	COG0489	protein tyrosine kinase activity
I6G42_RS03815	COG1442	glycosyl transferase family 8
I6G42_RS03820	COG3475	LICD family
I6G42_RS03825	COG0438	transferase activity, transferring glycosyl groups
I6G42_RS03830	COG1442	glycosyl transferase family 8
I6G42_RS03830	COG1216	Glycosyl transferase, family 2
I6G42_RS03835	COG1442	glycosyl transferase family 8
I6G42_RS03835	COG1216	Glycosyl transferase, family 2
I6G42_RS03850	COG3274	enterobacterial common antigen metabolic process
I6G42_RS03855	COG0562	UDP-galactopyranose mutase
I6G42_RS03860	COG4166	transmembrane transport
I6G42_RS03865	COG0366	Alpha amylase catalytic
I6G42_RS03865	COG0366	Alpha amylase catalytic
I6G42_RS03900	COG0116	Belongs to the methyltransferase superfamily
I6G42_RS03910	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6G42_RS03915	COG0745	RESPONSE REGULATOR receiver
I6G42_RS03920	COG5263	repeat protein
I6G42_RS03920	COG0366	Alpha amylase catalytic
I6G42_RS03950	COG4585	Histidine kinase
I6G42_RS03955	COG2197	response regulator
I6G42_RS03970	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G42_RS03975	COG0681	Belongs to the peptidase S26 family
I6G42_RS04000	COG1115	amino acid carrier protein
I6G42_RS04025	COG0527	aspartate kinase activity
I6G42_RS04030	COG1024	Enoyl-CoA hydratase
I6G42_RS04035	COG1846	Transcriptional regulator
I6G42_RS04045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G42_RS04055	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6G42_RS04060	COG1028	Short-chain dehydrogenase reductase Sdr
I6G42_RS04065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G42_RS04080	COG0439	Biotin carboxylase
I6G42_RS04085	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6G42_RS04120	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6G42_RS04140	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6G42_RS04150	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6G42_RS04155	COG0668	transmembrane transport
I6G42_RS04165	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6G42_RS04170	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6G42_RS04175	COG1534	Rna-binding protein
I6G42_RS04180	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6G42_RS04185	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6G42_RS04190	COG0799	negative regulation of ribosome biogenesis
I6G42_RS04195	COG2226	methyltransferase
I6G42_RS04215	COG0194	GDP metabolic process
I6G42_RS04225	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6G42_RS04235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G42_RS04235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G42_RS04240	COG0631	protein serine/threonine phosphatase activity
I6G42_RS04245	COG0515	serine threonine protein kinase
I6G42_RS04245	COG2815	serine threonine protein kinase
I6G42_RS04260	COG3425	synthase
I6G42_RS04270	COG1609	Transcriptional regulator
I6G42_RS04275	COG1621	beta-fructofuranosidase activity
I6G42_RS04280	COG1263	PTS System
I6G42_RS04280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G42_RS04280	COG2190	(PTS) system
I6G42_RS04285	COG1940	carbohydrate kinase activity
I6G42_RS04300	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6G42_RS04345	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
I6G42_RS04350	COG3620	sequence-specific DNA binding
I6G42_RS04355	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6G42_RS04370	COG1045	serine acetyltransferase
I6G42_RS04385	COG0215	cysteine-tRNA ligase activity
I6G42_RS04390	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6G42_RS04400	COG3842	ATPase activity
I6G42_RS04425	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6G42_RS04445	COG3590	peptidase
I6G42_RS04470	COG0745	RESPONSE REGULATOR receiver
I6G42_RS04490	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6G42_RS04510	COG1959	2 iron, 2 sulfur cluster binding
I6G42_RS04525	COG0765	amino acid transport
I6G42_RS04530	COG0765	amino acid transport
I6G42_RS04535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G42_RS04545	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6G42_RS04545	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6G42_RS04565	COG0322	excinuclease ABC activity
I6G42_RS04620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G42_RS04625	COG1573	uracil-dna glycosylase
I6G42_RS04635	COG0425	Belongs to the sulfur carrier protein TusA family
I6G42_RS04635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G42_RS04640	COG1114	Component of the transport system for branched-chain amino acids
I6G42_RS04645	COG4808	Protein conserved in bacteria
I6G42_RS04650	COG1363	Peptidase, m42
I6G42_RS04680	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G42_RS04690	COG3935	DnaD domain protein
I6G42_RS04715	COG2824	Alkylphosphonate utilization operon protein PhnA
I6G42_RS04735	COG0351	phosphomethylpyrimidine kinase
I6G42_RS04740	COG4720	Psort location CytoplasmicMembrane, score
I6G42_RS04745	COG0006	proline dipeptidase activity
I6G42_RS04750	COG3442	glutamine amidotransferase
I6G42_RS04755	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G42_RS04765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G42_RS04770	COG0513	Belongs to the DEAD box helicase family
I6G42_RS04775	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6G42_RS04780	COG1335	isochorismatase
I6G42_RS04790	COG0577	efflux transmembrane transporter activity
I6G42_RS04795	COG1136	(ABC) transporter
I6G42_RS04800	COG0577	efflux transmembrane transporter activity
I6G42_RS04805	COG0745	RESPONSE REGULATOR receiver
I6G42_RS04810	COG5002	protein histidine kinase activity
I6G42_RS04815	COG0191	fructose-bisphosphate aldolase activity
I6G42_RS04825	COG1401	restriction endodeoxyribonuclease activity
I6G42_RS04830	COG4268	DNA restriction-modification system
I6G42_RS04835	COG4555	ABC transporter
I6G42_RS04850	COG1404	Belongs to the peptidase S8 family
I6G42_RS04865	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G42_RS04865	COG2247	cell wall binding repeat
I6G42_RS04870	COG0583	DNA-binding transcription factor activity
I6G42_RS04890	COG1187	pseudouridine synthase activity
I6G42_RS04895	COG1217	gtp-binding protein TYPA
I6G42_RS04905	COG2233	PERMEase
I6G42_RS04920	COG0708	Exodeoxyribonuclease III
I6G42_RS04935	COG1132	(ABC) transporter
I6G42_RS04940	COG1132	(ABC) transporter
I6G42_RS04945	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6G42_RS04950	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6G42_RS04955	COG0133	tryptophan synthase activity
I6G42_RS04960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6G42_RS04965	COG0512	Glutamine amidotransferase of anthranilate synthase
I6G42_RS04980	COG0135	phosphoribosylanthranilate isomerase activity
I6G42_RS04990	COG0159	tryptophan synthase activity
I6G42_RS04995	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6G42_RS05015	COG0628	permease
I6G42_RS05035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6G42_RS05050	COG1051	belongs to the nudix hydrolase family
I6G42_RS05060	COG2264	protein methyltransferase activity
I6G42_RS05065	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6G42_RS05070	COG1164	Oligoendopeptidase f
I6G42_RS05080	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G42_RS05095	COG0720	synthase
I6G42_RS05105	COG3118	belongs to the thioredoxin family
I6G42_RS05125	COG1346	cytolysis
I6G42_RS05135	COG1131	(ABC) transporter
I6G42_RS05140	COG1725	Transcriptional regulator
I6G42_RS05155	COG1484	DNA-dependent DNA replication
I6G42_RS05180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G42_RS05180	COG1263	PTS System
I6G42_RS05180	COG2190	(PTS) system
I6G42_RS05195	COG0513	Belongs to the DEAD box helicase family
I6G42_RS05215	COG0542	response to heat
I6G42_RS05220	COG4703	Protein of unknown function (DUF1797)
I6G42_RS05225	COG0765	amino acid transport
I6G42_RS05230	COG1126	abc transporter atp-binding protein
I6G42_RS05240	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6G42_RS05250	COG3250	beta-galactosidase activity
I6G42_RS05260	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6G42_RS05265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G42_RS05265	COG1199	ATP-dependent helicase activity
I6G42_RS05270	COG0772	Belongs to the SEDS family
I6G42_RS05275	COG0693	protein deglycase activity
I6G42_RS05285	COG0187	DNA topoisomerase II activity
I6G42_RS05295	COG0726	polysaccharide deacetylase
I6G42_RS05300	COG0656	L-ascorbic acid biosynthetic process
I6G42_RS05350	COG1119	ATPase activity
I6G42_RS05365	COG0431	NADPH-dependent FMN reductase
I6G42_RS05365	COG3976	FMN-binding domain protein
I6G42_RS05365	COG1053	succinate dehydrogenase
I6G42_RS05395	COG1272	protein, Hemolysin III
I6G42_RS05410	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G42_RS05415	COG1393	Belongs to the ArsC family
I6G42_RS05425	COG1126	abc transporter atp-binding protein
I6G42_RS05435	COG0492	ferredoxin-NADP+ reductase activity
I6G42_RS05465	COG0561	phosphatase activity
I6G42_RS05485	COG1349	DNA-binding transcription factor activity
I6G42_RS05490	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G42_RS05495	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G42_RS05495	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G42_RS05495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G42_RS05500	COG0697	spore germination
I6G42_RS05500	COG1674	ftsk spoiiie
I6G42_RS05510	COG1104	cysteine desulfurase activity
I6G42_RS05535	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G42_RS05545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G42_RS05550	COG0697	spore germination
I6G42_RS05570	COG1704	LemA family
I6G42_RS05580	COG0488	(ABC) transporter
I6G42_RS05595	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6G42_RS05610	COG0505	Belongs to the CarA family
I6G42_RS05620	COG1914	H( )-stimulated, divalent metal cation uptake system
I6G42_RS05665	COG4974	Belongs to the 'phage' integrase family
I6G42_RS05675	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6G42_RS05680	COG0716	FMN binding
I6G42_RS05685	COG1605	Chorismate mutase
I6G42_RS05685	COG0077	Prephenate dehydratase
I6G42_RS05690	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6G42_RS05695	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6G42_RS05715	COG1518	maintenance of DNA repeat elements
I6G42_RS05735	COG1078	dGTPase activity
I6G42_RS05745	COG0513	Belongs to the DEAD box helicase family
I6G42_RS05780	COG0583	DNA-binding transcription factor activity
I6G42_RS05785	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6G42_RS05790	COG0564	pseudouridine synthase activity
I6G42_RS05805	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G42_RS05815	COG0470	DNA polymerase III
I6G42_RS05840	COG0528	UMP kinase activity
I6G42_RS05850	COG2996	Protein conserved in bacteria
I6G42_RS05855	COG0456	acetyltransferase
I6G42_RS05855	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6G42_RS05865	COG1702	phosphate starvation-inducible protein PhoH
I6G42_RS05870	COG0686	Belongs to the AlaDH PNT family
I6G42_RS05880	COG1555	photosystem II stabilization
I6G42_RS05880	COG1596	polysaccharide export
I6G42_RS05885	COG2333	competence protein COMEC
I6G42_RS05885	COG0658	competence protein
I6G42_RS05895	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6G42_RS05900	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6G42_RS05910	COG0543	2 iron, 2 sulfur cluster binding
I6G42_RS05915	COG0167	dihydroorotate dehydrogenase activity
I6G42_RS05920	COG5263	repeat protein
I6G42_RS05920	COG4193	domain, Protein
I6G42_RS05930	COG1028	Short-chain dehydrogenase reductase Sdr
I6G42_RS05960	COG0745	RESPONSE REGULATOR receiver
I6G42_RS05965	COG5002	protein histidine kinase activity
I6G42_RS06005	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6G42_RS06015	COG0813	purine-nucleoside phosphorylase activity
I6G42_RS06020	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I6G42_RS06030	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6G42_RS06040	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6G42_RS06045	COG0237	dephospho-CoA kinase activity
I6G42_RS06050	COG2814	Major facilitator Superfamily
I6G42_RS06055	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6G42_RS06065	COG0557	exoribonuclease II activity
I6G42_RS06075	COG0500	methyltransferase
I6G42_RS06075	COG3615	Tellurite resistance protein tehB
I6G42_RS06095	COG4122	O-methyltransferase activity
I6G42_RS06115	COG0772	Belongs to the SEDS family
I6G42_RS06120	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6G42_RS06140	COG0358	DNA primase activity
I6G42_RS06145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6G42_RS06150	COG2151	metal-sulfur cluster biosynthetic enzyme
I6G42_RS06155	COG0438	transferase activity, transferring glycosyl groups
I6G42_RS06160	COG0438	transferase activity, transferring glycosyl groups
I6G42_RS06185	COG1438	arginine binding
I6G42_RS06190	COG2936	dipeptidyl-peptidase activity
I6G42_RS06205	COG0469	pyruvate kinase activity
I6G42_RS06210	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6G42_RS06220	COG4109	DRTGG domain
I6G42_RS06225	COG0024	Methionine aminopeptidase
I6G42_RS06235	COG0785	Cytochrome C biogenesis protein
I6G42_RS06240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G42_RS06245	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G42_RS06245	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G42_RS06250	COG2207	Transcriptional regulator
I6G42_RS06250	COG4753	response regulator
I6G42_RS06255	COG2972	Histidine kinase
I6G42_RS06275	COG0785	Cytochrome C biogenesis protein
I6G42_RS06280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G42_RS06285	COG1686	Belongs to the peptidase S11 family
I6G42_RS06290	COG0628	permease
I6G42_RS06305	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6G42_RS06310	COG2205	protein histidine kinase activity
I6G42_RS06325	COG1136	(ABC) transporter
I6G42_RS06340	COG2188	Transcriptional regulator
I6G42_RS06345	COG0826	peptidase U32
I6G42_RS06395	COG2706	6-phosphogluconolactonase activity
I6G42_RS06400	COG0628	permease
I6G42_RS06415	COG1126	abc transporter atp-binding protein
I6G42_RS06420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G42_RS06435	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6G42_RS06450	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6G42_RS06475	COG2176	DNA-directed DNA polymerase activity
I6G42_RS06480	COG0584	glycerophosphoryl diester phosphodiesterase
I6G42_RS06535	COG0561	phosphatase activity
I6G42_RS06540	COG0561	phosphatase activity
I6G42_RS06545	COG0552	protein localization to endoplasmic reticulum
I6G42_RS06550	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6G42_RS06555	COG1126	abc transporter atp-binding protein
I6G42_RS06560	COG0765	amino acid transport
I6G42_RS06590	COG1827	regulation of RNA biosynthetic process
I6G42_RS06600	COG4684	Psort location CytoplasmicMembrane, score
I6G42_RS06605	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6G42_RS06620	COG0210	DNA helicase
I6G42_RS06630	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6G42_RS06650	COG1104	cysteine desulfurase activity
I6G42_RS06655	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6G42_RS06665	COG2357	RelA SpoT domain protein
I6G42_RS06675	COG0564	pseudouridine synthase activity
I6G42_RS06680	COG0280	phosphate acetyltransferase
I6G42_RS06685	COG1194	a g-specific adenine glycosylase
I6G42_RS06690	COG0745	RESPONSE REGULATOR receiver
I6G42_RS06695	COG5002	protein histidine kinase activity
I6G42_RS06700	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6G42_RS06715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G42_RS06720	COG0488	(ABC) transporter
I6G42_RS06740	COG1523	belongs to the glycosyl hydrolase 13 family
I6G42_RS06745	COG1012	belongs to the aldehyde dehydrogenase family
I6G42_RS06750	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6G42_RS06760	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6G42_RS06770	COG0560	Phosphoserine phosphatase
I6G42_RS06795	COG2207	Transcriptional regulator
I6G42_RS06795	COG3708	Transcriptional regulator
I6G42_RS06900	COG1011	Hydrolase
I6G42_RS06910	COG1051	belongs to the nudix hydrolase family
I6G42_RS06915	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6G42_RS06920	COG0534	Mate efflux family protein
I6G42_RS06925	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6G42_RS06930	COG0022	dehydrogenase e1 component
I6G42_RS06935	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G42_RS06940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G42_RS06945	COG0095	Lipoate-protein ligase
I6G42_RS06980	COG0038	chloride channel
I6G42_RS06990	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6G42_RS07020	COG1673	EVE domain
I6G42_RS07030	COG0561	phosphatase activity
I6G42_RS07035	COG1131	(ABC) transporter
I6G42_RS07045	COG2205	protein histidine kinase activity
I6G42_RS07050	COG0745	RESPONSE REGULATOR receiver
I6G42_RS07060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G42_RS07080	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6G42_RS07085	COG1982	Orn Lys Arg decarboxylase major
I6G42_RS07155	COG0366	Alpha amylase catalytic
I6G42_RS07160	COG0135	phosphoribosylanthranilate isomerase activity
I6G42_RS07190	COG0842	Transport permease protein
I6G42_RS07190	COG1129	ABC transporter
I6G42_RS07195	COG1725	Transcriptional regulator
I6G42_RS07205	COG0596	Alpha beta hydrolase
I6G42_RS07210	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G42_RS07220	COG0741	lytic transglycosylase activity
I6G42_RS07245	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G42_RS07255	COG1435	thymidine kinase activity
I6G42_RS07260	COG1942	4-Oxalocrotonate Tautomerase
I6G42_RS07265	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6G42_RS07275	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6G42_RS07285	COG4708	membrane
I6G42_RS07305	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G42_RS07315	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6G42_RS07315	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6G42_RS07330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G42_RS07340	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6G42_RS07345	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G42_RS07355	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G42_RS07365	COG2723	6-phospho-beta-galactosidase activity
I6G42_RS07380	COG3711	transcriptional antiterminator
I6G42_RS07385	COG3684	Belongs to the aldolase LacD family
I6G42_RS07410	COG3775	system Galactitol-specific IIC component
I6G42_RS07425	COG4750	Nucleotidyl transferase
I6G42_RS07430	COG0697	spore germination
I6G42_RS07440	COG1063	alcohol dehydrogenase
I6G42_RS07450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G42_RS07455	COG0805	protein transport
I6G42_RS07460	COG0672	)-iron permease
I6G42_RS07470	COG2822	iron ion transport
I6G42_RS07480	COG0577	efflux transmembrane transporter activity
I6G42_RS07485	COG1136	(ABC) transporter
I6G42_RS07495	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6G42_RS07510	COG2183	response to ionizing radiation
I6G42_RS07520	COG0701	Predicted permease
I6G42_RS07525	COG3689	TIGRFAM TIGR03943 family protein
I6G42_RS07540	COG3541	Predicted nucleotidyltransferase
I6G42_RS07545	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6G42_RS07575	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6G42_RS07580	COG0196	riboflavin kinase activity
I6G42_RS07585	COG1196	nuclear chromosome segregation
I6G42_RS07610	COG1401	restriction endodeoxyribonuclease activity
I6G42_RS07620	COG0066	3-isopropylmalate dehydratase activity
I6G42_RS07635	COG0473	3-isopropylmalate dehydrogenase activity
I6G42_RS07650	COG3142	Participates in the control of copper homeostasis
I6G42_RS07655	COG2832	Protein of unknown function (DUF454)
I6G42_RS07660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G42_RS07665	COG0758	DNA mediated transformation
I6G42_RS07675	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6G42_RS07680	COG0497	DNA recombination
I6G42_RS07685	COG1438	arginine binding
I6G42_RS07690	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6G42_RS07715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6G42_RS07770	COG3764	Sortase (surface protein transpeptidase)
I6G42_RS07775	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6G42_RS07790	COG1307	EDD domain protein, DegV family
I6G42_RS07795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G42_RS07800	COG0531	amino acid
I6G42_RS07805	COG0719	Fe-S assembly protein
I6G42_RS07815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6G42_RS07820	COG0719	Fe-S assembly protein
I6G42_RS07835	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6G42_RS07840	COG1956	GAF domain-containing protein
I6G42_RS07845	COG0539	negative regulation of cytoplasmic translation
I6G42_RS07865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G42_RS07870	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6G42_RS07895	COG0187	DNA topoisomerase II activity
I6G42_RS07905	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6G42_RS07910	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6G42_RS07915	COG3845	ABC transporter
I6G42_RS07920	COG1744	ABC transporter substrate-binding protein PnrA-like
I6G42_RS07925	COG0295	cytidine deaminase activity
I6G42_RS07935	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6G42_RS07940	COG2813	Specifically methylates the guanine in position
I6G42_RS07965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G42_RS07965	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G42_RS07970	COG0577	efflux transmembrane transporter activity
I6G42_RS07975	COG1136	(ABC) transporter
I6G42_RS07980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G42_RS07985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G42_RS07990	COG1268	BioY protein
I6G42_RS07995	COG4443	Transcriptional Coactivator p15 (PC4)
I6G42_RS08085	COG0488	(ABC) transporter
I6G42_RS08095	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6G42_RS08100	COG4470	Protein conserved in bacteria
I6G42_RS08105	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6G42_RS08115	COG0167	dihydroorotate dehydrogenase activity
I6G42_RS08120	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6G42_RS08140	COG0222	ribosome binding
I6G42_RS08145	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6G42_RS08150	COG0402	S-adenosylhomocysteine deaminase activity
I6G42_RS08165	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G42_RS08165	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G42_RS08195	COG3475	LICD family
I6G42_RS08200	COG3475	LICD family
I6G42_RS08205	COG1215	transferase activity, transferring glycosyl groups
I6G42_RS08210	COG3475	LICD family
I6G42_RS08220	COG0077	Prephenate dehydratase
I6G42_RS08235	COG3679	Belongs to the UPF0342 family
I6G42_RS08240	COG0287	Prephenate dehydrogenase
I6G42_RS08265	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6G42_RS08275	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G42_RS08300	COG3842	ATPase activity
I6G42_RS08315	COG3527	Alpha-acetolactate decarboxylase
I6G42_RS08320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G42_RS08325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G42_RS08330	COG0704	Plays a role in the regulation of phosphate uptake
I6G42_RS08335	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6G42_RS08340	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6G42_RS08345	COG0581	inorganic phosphate transmembrane transporter activity
I6G42_RS08350	COG0573	inorganic phosphate transmembrane transporter activity
I6G42_RS08355	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6G42_RS08360	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G42_RS08360	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6G42_RS08365	COG0483	inositol monophosphate 1-phosphatase activity
I6G42_RS08375	COG1393	Belongs to the ArsC family
I6G42_RS08385	COG0647	UMP catabolic process
I6G42_RS08395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G42_RS08420	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6G42_RS08450	COG1846	Transcriptional regulator
I6G42_RS08470	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6G42_RS08475	COG1242	4 iron, 4 sulfur cluster binding
I6G42_RS08485	COG2244	polysaccharide biosynthetic process
I6G42_RS08490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G42_RS08515	COG2827	Endonuclease containing a URI domain
I6G42_RS08520	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6G42_RS08525	COG1185	polyribonucleotide nucleotidyltransferase activity
I6G42_RS08540	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6G42_RS08545	COG0629	single-stranded DNA binding
I6G42_RS08550	COG0360	Binds together with S18 to 16S ribosomal RNA
I6G42_RS08560	COG0017	Asparaginyl-tRNA synthetase
I6G42_RS08565	COG0436	Aminotransferase
I6G42_RS08575	COG1846	Transcriptional regulator
I6G42_RS08595	COG0242	peptide deformylase activity
I6G42_RS08605	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6G42_RS08610	COG0488	(ABC) transporter
I6G42_RS08615	COG0617	tRNA 3'-terminal CCA addition
I6G42_RS08625	COG1307	EDD domain protein, DegV family
I6G42_RS08645	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6G42_RS08650	COG0492	ferredoxin-NADP+ reductase activity
I6G42_RS08660	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6G42_RS08670	COG0251	oxidation-reduction process
I6G42_RS08685	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6G42_RS08705	COG0463	Glycosyl transferase, family 2
I6G42_RS08710	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G42_RS08715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G42_RS08720	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6G42_RS08725	COG2384	SAM-dependent methyltransferase
I6G42_RS08730	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6G42_RS08735	COG0204	Acyl-transferase
I6G42_RS08760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G42_RS08775	COG0577	efflux transmembrane transporter activity
I6G42_RS08775	COG1136	(ABC) transporter
I6G42_RS08780	COG0588	phosphoglycerate mutase activity
I6G42_RS08790	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6G42_RS08800	COG2302	S4 RNA-binding domain
I6G42_RS08815	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6G42_RS08835	COG1051	belongs to the nudix hydrolase family
I6G42_RS08840	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G42_RS08875	COG0768	penicillin binding
I6G42_RS08885	COG2226	methyltransferase
I6G42_RS08895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G42_RS08905	COG2731	YhcH YjgK YiaL family protein
I6G42_RS08910	COG0395	ABC-type sugar transport system, permease component
I6G42_RS08915	COG1175	transmembrane transport
I6G42_RS08935	COG3458	cephalosporin-C deacetylase activity
I6G42_RS08940	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6G42_RS08955	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G42_RS08960	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G42_RS08980	COG2177	Part of the ABC transporter FtsEX involved in
I6G42_RS08985	COG2884	Cell division ATP-binding protein ftsE
I6G42_RS08995	COG0517	IMP dehydrogenase activity
I6G42_RS09015	COG4750	Nucleotidyl transferase
I6G42_RS09050	COG0740	serine-type endopeptidase activity
I6G42_RS09055	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6G42_RS09060	COG2131	deaminase
I6G42_RS09070	COG1307	EDD domain protein, DegV family
I6G42_RS09075	COG2081	HI0933 family
I6G42_RS09090	COG0519	Catalyzes the synthesis of GMP from XMP
I6G42_RS09100	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6G42_RS09130	COG1113	amino acid transport
I6G42_RS09140	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6G42_RS09165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G42_RS09170	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6G42_RS09175	COG0626	cystathionine gamma-synthase activity
I6G42_RS09180	COG4166	transmembrane transport
I6G42_RS09300	COG0438	transferase activity, transferring glycosyl groups
I6G42_RS09305	COG0438	transferase activity, transferring glycosyl groups
I6G42_RS09315	COG2723	6-phospho-beta-galactosidase activity
I6G42_RS09325	COG0653	protein targeting
I6G42_RS09345	COG0201	protein transport
I6G42_RS09350	COG3250	beta-galactosidase activity
I6G42_RS09355	COG0300	oxidoreductase activity
I6G42_RS09370	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6G42_RS09390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G42_RS09395	COG1940	carbohydrate kinase activity
I6G42_RS09405	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6G42_RS09410	COG3064	Membrane
I6G42_RS09420	COG0789	Transcriptional regulator
I6G42_RS09425	COG0733	neurotransmitter:sodium symporter activity
I6G42_RS09430	COG1482	cell wall glycoprotein biosynthetic process
I6G42_RS09435	COG2723	6-phospho-beta-galactosidase activity
I6G42_RS09455	COG0028	Belongs to the TPP enzyme family
I6G42_RS09460	COG2217	Heavy metal translocating P-type atpase
I6G42_RS09480	COG0352	thiamine-phosphate diphosphorylase activity
I6G42_RS09495	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6G42_RS09505	COG4172	Belongs to the ABC transporter superfamily
I6G42_RS09515	COG1304	FMN binding
I6G42_RS09525	COG4215	(ABC) transporter
I6G42_RS09530	COG1126	abc transporter atp-binding protein
I6G42_RS09535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G42_RS09550	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6G42_RS09575	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I6G42_RS09580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G42_RS09585	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6G42_RS09590	COG1609	Transcriptional regulator
I6G42_RS09600	COG1136	(ABC) transporter
I6G42_RS09600	COG0577	efflux transmembrane transporter activity
I6G42_RS09620	COG1174	glycine betaine transport
I6G42_RS09625	COG1125	glycine betaine transport
I6G42_RS09625	COG0517	IMP dehydrogenase activity
I6G42_RS09640	COG1846	Transcriptional regulator
I6G42_RS09650	COG0366	Alpha amylase catalytic
I6G42_RS09655	COG0395	ABC-type sugar transport system, permease component
I6G42_RS09660	COG1175	transmembrane transport
I6G42_RS09665	COG1653	transport
I6G42_RS09670	COG3345	alpha-galactosidase
I6G42_RS09675	COG2207	Transcriptional regulator
I6G42_RS09810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G42_RS09845	COG4221	oxidoreductase activity
I6G42_RS09850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G42_RS09855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G42_RS09865	COG0504	CTP synthase activity
I6G42_RS09900	COG0525	valine-tRNA ligase activity
I6G42_RS09910	COG0519	Catalyzes the synthesis of GMP from XMP
I6G42_RS09950	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6G42_RS09955	COG0195	Participates in both transcription termination and antitermination