locus-tag	class	description
I6G43_RS00010	COG1328	CTP reductase activity
I6G43_RS00025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G43_RS00030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G43_RS00040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G43_RS00045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G43_RS00055	COG1454	alcohol dehydrogenase
I6G43_RS00065	COG0285	dihydrofolate synthase activity
I6G43_RS00090	COG1393	Belongs to the ArsC family
I6G43_RS00095	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6G43_RS00100	COG0006	proline dipeptidase activity
I6G43_RS00105	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6G43_RS00140	COG2818	Glycosylase
I6G43_RS00150	COG1395	domain, Protein
I6G43_RS00175	COG1438	arginine binding
I6G43_RS00195	COG1780	Probably involved in ribonucleotide reductase function
I6G43_RS00205	COG4753	response regulator
I6G43_RS00205	COG2207	Transcriptional regulator
I6G43_RS00210	COG2972	Histidine kinase
I6G43_RS00230	COG1696	Membrane protein involved in D-alanine export
I6G43_RS00240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G43_RS00245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G43_RS00250	COG1464	Belongs to the NlpA lipoprotein family
I6G43_RS00255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G43_RS00290	COG1396	sequence-specific DNA binding
I6G43_RS00295	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6G43_RS00305	COG1214	PFAM Peptidase M22, glycoprotease
I6G43_RS00330	COG0494	nUDIX hydrolase
I6G43_RS00345	COG0137	argininosuccinate synthase activity
I6G43_RS00350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G43_RS00355	COG0577	efflux transmembrane transporter activity
I6G43_RS00355	COG1136	(ABC) transporter
I6G43_RS00370	COG3584	3D domain protein
I6G43_RS00370	COG1388	LysM domain
I6G43_RS00375	COG1760	l-serine dehydratase
I6G43_RS00380	COG1760	l-serine dehydratase
I6G43_RS00385	COG0546	phosphoglycolate phosphatase activity
I6G43_RS00395	COG1216	Glycosyl transferase, family 2
I6G43_RS00400	COG2807	transmembrane transport
I6G43_RS00440	COG1653	transport
I6G43_RS00445	COG0395	ABC-type sugar transport system, permease component
I6G43_RS00450	COG4209	transmembrane transport
I6G43_RS00470	COG0383	alpha-mannosidase activity
I6G43_RS00480	COG3537	Alpha-1,2-mannosidase
I6G43_RS00500	COG0549	Belongs to the carbamate kinase family
I6G43_RS00505	COG1288	antiporter activity
I6G43_RS00510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G43_RS00515	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6G43_RS00515	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6G43_RS00520	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G43_RS00525	COG1121	(ABC) transporter
I6G43_RS00530	COG1846	Transcriptional regulator
I6G43_RS00535	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6G43_RS00545	COG1696	Membrane protein involved in D-alanine export
I6G43_RS00565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G43_RS00580	COG3201	nicotinamide mononucleotide transporter
I6G43_RS00585	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6G43_RS00590	COG0542	response to heat
I6G43_RS00595	COG4463	regulation of RNA biosynthetic process
I6G43_RS00615	COG1116	anion transmembrane transporter activity
I6G43_RS00620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G43_RS00625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G43_RS00635	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G43_RS00635	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G43_RS00640	COG3942	CHAP domain
I6G43_RS00650	COG0305	Participates in initiation and elongation during chromosome replication
I6G43_RS00675	COG1040	competence protein
I6G43_RS00680	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6G43_RS00685	COG1739	Uncharacterized protein family UPF0029
I6G43_RS00705	COG3942	CHAP domain
I6G43_RS00715	COG1792	Involved in formation and maintenance of cell shape
I6G43_RS00720	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6G43_RS00725	COG1122	ATPase activity
I6G43_RS00730	COG1122	ATPase activity
I6G43_RS00735	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6G43_RS00745	COG0612	Peptidase, M16
I6G43_RS00750	COG0612	Peptidase, M16
I6G43_RS00755	COG2501	S4 domain
I6G43_RS00765	COG0517	IMP dehydrogenase activity
I6G43_RS00765	COG0516	GMP reductase activity
I6G43_RS00770	COG0180	Tryptophanyl-tRNA synthetase
I6G43_RS00775	COG0488	(ABC) transporter
I6G43_RS00785	COG1511	domain protein
I6G43_RS00785	COG1511	domain protein
I6G43_RS00830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G43_RS00835	COG1475	DNA binding
I6G43_RS00845	COG0592	DNA-directed DNA polymerase activity
I6G43_RS00855	COG0012	GTP binding
I6G43_RS00865	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6G43_RS00870	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6G43_RS00890	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6G43_RS00895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G43_RS00960	COG0756	dUTP diphosphatase activity
I6G43_RS00970	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6G43_RS00980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6G43_RS00985	COG1832	CoA-binding protein
I6G43_RS00990	COG2855	membrane
I6G43_RS00995	COG0436	Aminotransferase
I6G43_RS01010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G43_RS01040	COG2274	protein secretion by the type I secretion system
I6G43_RS01045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G43_RS01055	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6G43_RS01065	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6G43_RS01070	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6G43_RS01080	COG0151	Belongs to the GarS family
I6G43_RS01085	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6G43_RS01105	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6G43_RS01110	COG3064	Membrane
I6G43_RS01110	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6G43_RS01110	COG3583	domain protein
I6G43_RS01125	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G43_RS01130	COG3715	PTS system
I6G43_RS01135	COG3716	PTS system mannose fructose sorbose family IID component
I6G43_RS01145	COG2222	sugar isomerase
I6G43_RS01150	COG3684	Belongs to the aldolase LacD family
I6G43_RS01185	COG0745	RESPONSE REGULATOR receiver
I6G43_RS01190	COG2357	RelA SpoT domain protein
I6G43_RS01195	COG1937	Protein conserved in bacteria
I6G43_RS01210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G43_RS01210	COG0425	Belongs to the sulfur carrier protein TusA family
I6G43_RS01215	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G43_RS01220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G43_RS01220	COG0425	Belongs to the sulfur carrier protein TusA family
I6G43_RS01225	COG0110	maltose O-acetyltransferase activity
I6G43_RS01240	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G43_RS01255	COG0745	RESPONSE REGULATOR receiver
I6G43_RS01260	COG5002	protein histidine kinase activity
I6G43_RS01275	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6G43_RS01290	COG2151	metal-sulfur cluster biosynthetic enzyme
I6G43_RS01305	COG0124	histidyl-tRNA synthetase
I6G43_RS01325	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G43_RS01335	COG4842	Belongs to the WXG100 family
I6G43_RS01350	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6G43_RS01355	COG1674	ftsk spoiiie
I6G43_RS01450	COG1609	Transcriptional regulator
I6G43_RS01455	COG5521	maltodextrose utilization protein MalA
I6G43_RS01460	COG3833	ABC-type maltose transport systems, permease component
I6G43_RS01465	COG1175	transmembrane transport
I6G43_RS01470	COG2182	Extracellular solute-binding protein
I6G43_RS01475	COG1640	4-alpha-glucanotransferase
I6G43_RS01480	COG0058	SHG alpha-glucan phosphorylase activity
I6G43_RS01485	COG2226	methyltransferase
I6G43_RS01495	COG2217	Heavy metal translocating P-type atpase
I6G43_RS01505	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6G43_RS01505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G43_RS01510	COG0697	spore germination
I6G43_RS01525	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6G43_RS01535	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G43_RS01545	COG1132	(ABC) transporter
I6G43_RS01550	COG1132	(ABC) transporter
I6G43_RS01555	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6G43_RS01560	COG0166	Belongs to the GPI family
I6G43_RS01580	COG3730	PTS system glucitol sorbitol-specific
I6G43_RS01585	COG3732	PTS system glucitol sorbitol-specific
I6G43_RS01705	COG0534	Mate efflux family protein
I6G43_RS01710	COG0546	phosphoglycolate phosphatase activity
I6G43_RS01720	COG1846	Transcriptional regulator
I6G43_RS01725	COG3759	membrane
I6G43_RS01760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G43_RS01765	COG1459	type II secretion system
I6G43_RS01770	COG4537	Required for transformation and DNA binding
I6G43_RS01815	COG0706	membrane insertase activity
I6G43_RS01820	COG1847	R3H domain protein
I6G43_RS01830	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6G43_RS01840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G43_RS01850	COG1454	alcohol dehydrogenase
I6G43_RS01850	COG1012	belongs to the aldehyde dehydrogenase family
I6G43_RS01860	COG0564	pseudouridine synthase activity
I6G43_RS01865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G43_RS01870	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6G43_RS01965	COG1523	belongs to the glycosyl hydrolase 13 family
I6G43_RS01985	COG0802	atpase or kinase
I6G43_RS01995	COG1316	TRANSCRIPTIONal
I6G43_RS02015	COG0534	Mate efflux family protein
I6G43_RS02060	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6G43_RS02070	COG1461	Dihydroxyacetone kinase
I6G43_RS02085	COG1131	(ABC) transporter
I6G43_RS02095	COG4585	Histidine kinase
I6G43_RS02100	COG2197	response regulator
I6G43_RS02120	COG0028	Belongs to the TPP enzyme family
I6G43_RS02125	COG0440	acetolactate synthase activity
I6G43_RS02135	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G43_RS02155	COG0765	amino acid transport
I6G43_RS02170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G43_RS02175	COG1882	Formate acetyltransferase
I6G43_RS02220	COG0366	Alpha amylase catalytic
I6G43_RS02225	COG4166	transmembrane transport
I6G43_RS02230	COG4166	transmembrane transport
I6G43_RS02235	COG1316	TRANSCRIPTIONal
I6G43_RS02240	COG4464	protein tyrosine phosphatase activity
I6G43_RS02245	COG3944	biosynthesis protein
I6G43_RS02250	COG0489	protein tyrosine kinase activity
I6G43_RS02300	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6G43_RS02310	COG1088	dTDP-glucose 4,6-dehydratase activity
I6G43_RS02315	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6G43_RS02320	COG4166	transmembrane transport
I6G43_RS02325	COG0366	Alpha amylase catalytic
I6G43_RS02325	COG0366	Alpha amylase catalytic
I6G43_RS02360	COG0116	Belongs to the methyltransferase superfamily
I6G43_RS02370	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6G43_RS02375	COG0745	RESPONSE REGULATOR receiver
I6G43_RS02410	COG4585	Histidine kinase
I6G43_RS02415	COG2197	response regulator
I6G43_RS02430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G43_RS02435	COG0681	Belongs to the peptidase S26 family
I6G43_RS02460	COG1115	amino acid carrier protein
I6G43_RS02485	COG0527	aspartate kinase activity
I6G43_RS02490	COG1024	Enoyl-CoA hydratase
I6G43_RS02495	COG1846	Transcriptional regulator
I6G43_RS02505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G43_RS02515	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6G43_RS02525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G43_RS02540	COG0439	Biotin carboxylase
I6G43_RS02545	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6G43_RS02595	COG0697	spore germination
I6G43_RS02600	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6G43_RS02610	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6G43_RS02615	COG0668	transmembrane transport
I6G43_RS02625	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6G43_RS02630	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6G43_RS02635	COG1534	Rna-binding protein
I6G43_RS02640	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6G43_RS02645	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6G43_RS02650	COG0799	negative regulation of ribosome biogenesis
I6G43_RS02655	COG2226	methyltransferase
I6G43_RS02675	COG0194	GDP metabolic process
I6G43_RS02685	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6G43_RS02695	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G43_RS02695	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G43_RS02700	COG0631	protein serine/threonine phosphatase activity
I6G43_RS02705	COG2815	serine threonine protein kinase
I6G43_RS02705	COG0515	serine threonine protein kinase
I6G43_RS02720	COG3425	synthase
I6G43_RS02730	COG1609	Transcriptional regulator
I6G43_RS02735	COG1621	beta-fructofuranosidase activity
I6G43_RS02740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G43_RS02740	COG2190	(PTS) system
I6G43_RS02740	COG1263	PTS System
I6G43_RS02745	COG1940	carbohydrate kinase activity
I6G43_RS02815	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
I6G43_RS02820	COG3620	sequence-specific DNA binding
I6G43_RS02825	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6G43_RS02840	COG1045	serine acetyltransferase
I6G43_RS02855	COG0215	cysteine-tRNA ligase activity
I6G43_RS02860	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6G43_RS02870	COG3842	ATPase activity
I6G43_RS02895	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6G43_RS02915	COG3590	peptidase
I6G43_RS02940	COG0745	RESPONSE REGULATOR receiver
I6G43_RS02960	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6G43_RS02980	COG1959	2 iron, 2 sulfur cluster binding
I6G43_RS02995	COG0765	amino acid transport
I6G43_RS03000	COG0765	amino acid transport
I6G43_RS03005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G43_RS03015	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6G43_RS03015	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6G43_RS03035	COG0322	excinuclease ABC activity
I6G43_RS03070	COG1573	uracil-dna glycosylase
I6G43_RS03085	COG1114	Component of the transport system for branched-chain amino acids
I6G43_RS03090	COG1363	Peptidase, m42
I6G43_RS03120	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G43_RS03130	COG3935	DnaD domain protein
I6G43_RS03135	COG0149	triose-phosphate isomerase activity
I6G43_RS03145	COG1132	(ABC) transporter
I6G43_RS03155	COG2824	Alkylphosphonate utilization operon protein PhnA
I6G43_RS03175	COG0351	phosphomethylpyrimidine kinase
I6G43_RS03180	COG4720	Psort location CytoplasmicMembrane, score
I6G43_RS03185	COG0006	proline dipeptidase activity
I6G43_RS03190	COG3442	glutamine amidotransferase
I6G43_RS03195	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G43_RS03205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G43_RS03210	COG0513	Belongs to the DEAD box helicase family
I6G43_RS03215	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6G43_RS03220	COG1335	isochorismatase
I6G43_RS03230	COG0577	efflux transmembrane transporter activity
I6G43_RS03235	COG1136	(ABC) transporter
I6G43_RS03240	COG0577	efflux transmembrane transporter activity
I6G43_RS03245	COG0745	RESPONSE REGULATOR receiver
I6G43_RS03250	COG5002	protein histidine kinase activity
I6G43_RS03255	COG0191	fructose-bisphosphate aldolase activity
I6G43_RS03265	COG1401	restriction endodeoxyribonuclease activity
I6G43_RS03270	COG4268	DNA restriction-modification system
I6G43_RS03275	COG4555	ABC transporter
I6G43_RS03290	COG1404	Belongs to the peptidase S8 family
I6G43_RS03315	COG0583	DNA-binding transcription factor activity
I6G43_RS03335	COG1187	pseudouridine synthase activity
I6G43_RS03340	COG1217	gtp-binding protein TYPA
I6G43_RS03350	COG2233	PERMEase
I6G43_RS03365	COG0708	Exodeoxyribonuclease III
I6G43_RS03380	COG1132	(ABC) transporter
I6G43_RS03385	COG1132	(ABC) transporter
I6G43_RS03390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6G43_RS03395	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6G43_RS03400	COG0133	tryptophan synthase activity
I6G43_RS03405	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6G43_RS03410	COG0512	Glutamine amidotransferase of anthranilate synthase
I6G43_RS03425	COG0135	phosphoribosylanthranilate isomerase activity
I6G43_RS03440	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6G43_RS03465	COG0628	permease
I6G43_RS03485	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6G43_RS03510	COG2264	protein methyltransferase activity
I6G43_RS03515	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6G43_RS03520	COG1164	Oligoendopeptidase f
I6G43_RS03530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G43_RS03545	COG0720	synthase
I6G43_RS03555	COG3118	belongs to the thioredoxin family
I6G43_RS03575	COG1346	cytolysis
I6G43_RS03585	COG1131	(ABC) transporter
I6G43_RS03590	COG1725	Transcriptional regulator
I6G43_RS03605	COG1484	DNA-dependent DNA replication
I6G43_RS03630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G43_RS03630	COG1263	PTS System
I6G43_RS03630	COG2190	(PTS) system
I6G43_RS03645	COG0513	Belongs to the DEAD box helicase family
I6G43_RS03665	COG0542	response to heat
I6G43_RS03670	COG4703	Protein of unknown function (DUF1797)
I6G43_RS03675	COG0765	amino acid transport
I6G43_RS03680	COG1126	abc transporter atp-binding protein
I6G43_RS03690	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6G43_RS03700	COG3250	beta-galactosidase activity
I6G43_RS03710	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6G43_RS03715	COG1199	ATP-dependent helicase activity
I6G43_RS03715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G43_RS03720	COG0772	Belongs to the SEDS family
I6G43_RS03725	COG0693	protein deglycase activity
I6G43_RS03735	COG0187	DNA topoisomerase II activity
I6G43_RS03745	COG0726	polysaccharide deacetylase
I6G43_RS03750	COG0656	L-ascorbic acid biosynthetic process
I6G43_RS03765	COG0751	glycine-tRNA ligase activity
I6G43_RS03775	COG0431	NADPH-dependent FMN reductase
I6G43_RS03775	COG1053	succinate dehydrogenase
I6G43_RS03775	COG3976	FMN-binding domain protein
I6G43_RS03805	COG1272	protein, Hemolysin III
I6G43_RS03825	COG1393	Belongs to the ArsC family
I6G43_RS03835	COG1126	abc transporter atp-binding protein
I6G43_RS03845	COG0492	ferredoxin-NADP+ reductase activity
I6G43_RS03865	COG0561	phosphatase activity
I6G43_RS03885	COG1349	DNA-binding transcription factor activity
I6G43_RS03890	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G43_RS03895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G43_RS03895	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G43_RS03895	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G43_RS03900	COG1674	ftsk spoiiie
I6G43_RS03900	COG0697	spore germination
I6G43_RS03910	COG1104	cysteine desulfurase activity
I6G43_RS03935	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G43_RS03945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G43_RS03950	COG0697	spore germination
I6G43_RS03970	COG1704	LemA family
I6G43_RS03980	COG0488	(ABC) transporter
I6G43_RS03995	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6G43_RS04010	COG0505	Belongs to the CarA family
I6G43_RS04020	COG1914	H( )-stimulated, divalent metal cation uptake system
I6G43_RS04030	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6G43_RS04035	COG0716	FMN binding
I6G43_RS04040	COG1605	Chorismate mutase
I6G43_RS04040	COG0077	Prephenate dehydratase
I6G43_RS04045	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6G43_RS04050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6G43_RS04095	COG1396	sequence-specific DNA binding
I6G43_RS04135	COG1674	ftsk spoiiie
I6G43_RS04140	COG2946	Replication initiation factor
I6G43_RS04150	COG1396	sequence-specific DNA binding
I6G43_RS04190	COG0433	COG0433 Predicted ATPase
I6G43_RS04200	COG3942	CHAP domain
I6G43_RS04200	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6G43_RS04230	COG0582	viral genome integration into host DNA
I6G43_RS04240	COG1518	maintenance of DNA repeat elements
I6G43_RS04260	COG1078	dGTPase activity
I6G43_RS04270	COG0513	Belongs to the DEAD box helicase family
I6G43_RS04300	COG0583	DNA-binding transcription factor activity
I6G43_RS04305	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6G43_RS04310	COG0564	pseudouridine synthase activity
I6G43_RS04320	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6G43_RS04325	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G43_RS04335	COG0470	DNA polymerase III
I6G43_RS04380	COG0528	UMP kinase activity
I6G43_RS04390	COG2996	Protein conserved in bacteria
I6G43_RS04395	COG0456	acetyltransferase
I6G43_RS04395	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6G43_RS04405	COG1702	phosphate starvation-inducible protein PhoH
I6G43_RS04410	COG0686	Belongs to the AlaDH PNT family
I6G43_RS04420	COG1596	polysaccharide export
I6G43_RS04420	COG1555	photosystem II stabilization
I6G43_RS04425	COG2333	competence protein COMEC
I6G43_RS04425	COG0658	competence protein
I6G43_RS04435	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6G43_RS04440	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6G43_RS04450	COG0543	2 iron, 2 sulfur cluster binding
I6G43_RS04455	COG0167	dihydroorotate dehydrogenase activity
I6G43_RS04460	COG5263	repeat protein
I6G43_RS04460	COG4193	domain, Protein
I6G43_RS04470	COG1028	Short-chain dehydrogenase reductase Sdr
I6G43_RS04500	COG0745	RESPONSE REGULATOR receiver
I6G43_RS04505	COG5002	protein histidine kinase activity
I6G43_RS04520	COG1136	(ABC) transporter
I6G43_RS04545	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6G43_RS04555	COG0813	purine-nucleoside phosphorylase activity
I6G43_RS04560	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I6G43_RS04570	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6G43_RS04575	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6G43_RS04580	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6G43_RS04585	COG0237	dephospho-CoA kinase activity
I6G43_RS04590	COG2814	Major facilitator Superfamily
I6G43_RS04595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6G43_RS04605	COG0557	exoribonuclease II activity
I6G43_RS04615	COG3615	Tellurite resistance protein tehB
I6G43_RS04615	COG0500	methyltransferase
I6G43_RS04635	COG4122	O-methyltransferase activity
I6G43_RS04645	COG0772	Belongs to the SEDS family
I6G43_RS04650	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6G43_RS04665	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G43_RS04670	COG0358	DNA primase activity
I6G43_RS04675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6G43_RS04680	COG2151	metal-sulfur cluster biosynthetic enzyme
I6G43_RS04685	COG0438	transferase activity, transferring glycosyl groups
I6G43_RS04690	COG0438	transferase activity, transferring glycosyl groups
I6G43_RS04715	COG1438	arginine binding
I6G43_RS04720	COG2936	dipeptidyl-peptidase activity
I6G43_RS04735	COG0469	pyruvate kinase activity
I6G43_RS04740	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6G43_RS04745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G43_RS04750	COG4109	DRTGG domain
I6G43_RS04755	COG0024	Methionine aminopeptidase
I6G43_RS04765	COG0785	Cytochrome C biogenesis protein
I6G43_RS04770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G43_RS04775	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G43_RS04775	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G43_RS04780	COG4753	response regulator
I6G43_RS04780	COG2207	Transcriptional regulator
I6G43_RS04785	COG2972	Histidine kinase
I6G43_RS04805	COG0785	Cytochrome C biogenesis protein
I6G43_RS04810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G43_RS04815	COG1686	Belongs to the peptidase S11 family
I6G43_RS04820	COG0628	permease
I6G43_RS04835	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6G43_RS04840	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6G43_RS04855	COG1136	(ABC) transporter
I6G43_RS04870	COG0210	DNA helicase
I6G43_RS04885	COG2188	Transcriptional regulator
I6G43_RS04890	COG0826	peptidase U32
I6G43_RS04940	COG2706	6-phosphogluconolactonase activity
I6G43_RS04945	COG0628	permease
I6G43_RS04960	COG1126	abc transporter atp-binding protein
I6G43_RS04965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G43_RS04980	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6G43_RS04995	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6G43_RS05000	COG0494	nUDIX hydrolase
I6G43_RS05020	COG2176	DNA-directed DNA polymerase activity
I6G43_RS05025	COG0584	glycerophosphoryl diester phosphodiesterase
I6G43_RS05040	COG0561	phosphatase activity
I6G43_RS05045	COG0561	phosphatase activity
I6G43_RS05050	COG0552	protein localization to endoplasmic reticulum
I6G43_RS05055	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6G43_RS05060	COG1126	abc transporter atp-binding protein
I6G43_RS05065	COG0765	amino acid transport
I6G43_RS05070	COG0556	nucleotide-excision repair
I6G43_RS05105	COG1827	regulation of RNA biosynthetic process
I6G43_RS05115	COG4684	Psort location CytoplasmicMembrane, score
I6G43_RS05120	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6G43_RS05155	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6G43_RS05175	COG1104	cysteine desulfurase activity
I6G43_RS05180	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6G43_RS05190	COG2357	RelA SpoT domain protein
I6G43_RS05200	COG0564	pseudouridine synthase activity
I6G43_RS05205	COG0280	phosphate acetyltransferase
I6G43_RS05210	COG1194	a g-specific adenine glycosylase
I6G43_RS05215	COG0745	RESPONSE REGULATOR receiver
I6G43_RS05220	COG5002	protein histidine kinase activity
I6G43_RS05225	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6G43_RS05235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G43_RS05240	COG0488	(ABC) transporter
I6G43_RS05260	COG1523	belongs to the glycosyl hydrolase 13 family
I6G43_RS05265	COG1012	belongs to the aldehyde dehydrogenase family
I6G43_RS05270	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6G43_RS05280	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6G43_RS05290	COG0560	Phosphoserine phosphatase
I6G43_RS05315	COG2207	Transcriptional regulator
I6G43_RS05315	COG3708	Transcriptional regulator
I6G43_RS05335	COG1011	Hydrolase
I6G43_RS05345	COG1051	belongs to the nudix hydrolase family
I6G43_RS05350	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6G43_RS05355	COG0534	Mate efflux family protein
I6G43_RS05360	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6G43_RS05365	COG0022	dehydrogenase e1 component
I6G43_RS05370	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G43_RS05375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G43_RS05380	COG0095	Lipoate-protein ligase
I6G43_RS05410	COG0038	chloride channel
I6G43_RS05420	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6G43_RS05450	COG1673	EVE domain
I6G43_RS05460	COG0561	phosphatase activity
I6G43_RS05465	COG1131	(ABC) transporter
I6G43_RS05475	COG2205	protein histidine kinase activity
I6G43_RS05480	COG0745	RESPONSE REGULATOR receiver
I6G43_RS05490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G43_RS05510	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6G43_RS05515	COG1982	Orn Lys Arg decarboxylase major
I6G43_RS05540	COG0366	Alpha amylase catalytic
I6G43_RS05550	COG1597	lipid kinase activity
I6G43_RS05585	COG1132	(ABC) transporter
I6G43_RS05590	COG1131	(ABC) transporter
I6G43_RS05635	COG0488	(ABC) transporter
I6G43_RS05650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G43_RS05660	COG0741	lytic transglycosylase activity
I6G43_RS05685	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G43_RS05690	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6G43_RS05695	COG1435	thymidine kinase activity
I6G43_RS05700	COG1942	4-Oxalocrotonate Tautomerase
I6G43_RS05705	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6G43_RS05715	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6G43_RS05725	COG4708	membrane
I6G43_RS05735	COG1970	mechanosensitive ion channel activity
I6G43_RS05745	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G43_RS05755	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6G43_RS05755	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6G43_RS05770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G43_RS05780	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6G43_RS05785	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G43_RS05790	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G43_RS05800	COG2723	6-phospho-beta-galactosidase activity
I6G43_RS05815	COG3711	transcriptional antiterminator
I6G43_RS05820	COG3684	Belongs to the aldolase LacD family
I6G43_RS05845	COG3775	system Galactitol-specific IIC component
I6G43_RS05860	COG4750	Nucleotidyl transferase
I6G43_RS05865	COG0697	spore germination
I6G43_RS05875	COG1063	alcohol dehydrogenase
I6G43_RS05885	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G43_RS05890	COG0805	protein transport
I6G43_RS05895	COG0672	)-iron permease
I6G43_RS05910	COG0577	efflux transmembrane transporter activity
I6G43_RS05915	COG1136	(ABC) transporter
I6G43_RS05930	COG2183	response to ionizing radiation
I6G43_RS05935	COG0701	Predicted permease
I6G43_RS05940	COG3689	TIGRFAM TIGR03943 family protein
I6G43_RS05955	COG3541	Predicted nucleotidyltransferase
I6G43_RS05960	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6G43_RS05990	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6G43_RS05995	COG0196	riboflavin kinase activity
I6G43_RS06000	COG1196	nuclear chromosome segregation
I6G43_RS06030	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6G43_RS06045	COG0066	3-isopropylmalate dehydratase activity
I6G43_RS06060	COG0473	3-isopropylmalate dehydrogenase activity
I6G43_RS06075	COG3142	Participates in the control of copper homeostasis
I6G43_RS06080	COG2832	Protein of unknown function (DUF454)
I6G43_RS06085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G43_RS06090	COG0758	DNA mediated transformation
I6G43_RS06100	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6G43_RS06105	COG0497	DNA recombination
I6G43_RS06110	COG1438	arginine binding
I6G43_RS06115	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6G43_RS06140	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6G43_RS06185	COG3764	Sortase (surface protein transpeptidase)
I6G43_RS06190	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6G43_RS06195	COG0039	L-malate dehydrogenase activity
I6G43_RS06205	COG1307	EDD domain protein, DegV family
I6G43_RS06210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G43_RS06215	COG0531	amino acid
I6G43_RS06220	COG0719	Fe-S assembly protein
I6G43_RS06230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6G43_RS06235	COG0719	Fe-S assembly protein
I6G43_RS06250	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6G43_RS06255	COG1956	GAF domain-containing protein
I6G43_RS06260	COG0539	negative regulation of cytoplasmic translation
I6G43_RS06280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G43_RS06285	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6G43_RS06310	COG0187	DNA topoisomerase II activity
I6G43_RS06320	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6G43_RS06325	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6G43_RS06330	COG3845	ABC transporter
I6G43_RS06335	COG1744	ABC transporter substrate-binding protein PnrA-like
I6G43_RS06340	COG0295	cytidine deaminase activity
I6G43_RS06350	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6G43_RS06355	COG2813	Specifically methylates the guanine in position
I6G43_RS06370	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6G43_RS06375	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G43_RS06375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G43_RS06380	COG0577	efflux transmembrane transporter activity
I6G43_RS06385	COG1136	(ABC) transporter
I6G43_RS06390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G43_RS06395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G43_RS06400	COG1268	BioY protein
I6G43_RS06405	COG4443	Transcriptional Coactivator p15 (PC4)
I6G43_RS06430	COG2267	carboxylic ester hydrolase activity
I6G43_RS06435	COG0697	spore germination
I6G43_RS06505	COG0488	(ABC) transporter
I6G43_RS06515	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6G43_RS06520	COG4470	Protein conserved in bacteria
I6G43_RS06525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6G43_RS06535	COG0167	dihydroorotate dehydrogenase activity
I6G43_RS06540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6G43_RS06560	COG0222	ribosome binding
I6G43_RS06565	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6G43_RS06570	COG0402	S-adenosylhomocysteine deaminase activity
I6G43_RS06580	COG1132	(ABC) transporter
I6G43_RS06585	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G43_RS06585	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G43_RS06615	COG3475	LICD family
I6G43_RS06620	COG3475	LICD family
I6G43_RS06625	COG1215	transferase activity, transferring glycosyl groups
I6G43_RS06630	COG3475	LICD family
I6G43_RS06640	COG0077	Prephenate dehydratase
I6G43_RS06645	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6G43_RS06655	COG3679	Belongs to the UPF0342 family
I6G43_RS06660	COG0287	Prephenate dehydrogenase
I6G43_RS06685	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6G43_RS06695	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G43_RS06715	COG1177	transmembrane transport
I6G43_RS06720	COG3842	ATPase activity
I6G43_RS06730	COG2207	Transcriptional regulator
I6G43_RS06740	COG1609	Transcriptional regulator
I6G43_RS06755	COG3527	Alpha-acetolactate decarboxylase
I6G43_RS06760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G43_RS06765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G43_RS06770	COG0704	Plays a role in the regulation of phosphate uptake
I6G43_RS06775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6G43_RS06780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6G43_RS06785	COG0581	inorganic phosphate transmembrane transporter activity
I6G43_RS06790	COG0573	inorganic phosphate transmembrane transporter activity
I6G43_RS06795	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6G43_RS06800	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6G43_RS06800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G43_RS06805	COG0483	inositol monophosphate 1-phosphatase activity
I6G43_RS06815	COG1393	Belongs to the ArsC family
I6G43_RS06825	COG0647	UMP catabolic process
I6G43_RS06835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G43_RS06860	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6G43_RS06875	COG4106	trans-aconitate 2-methyltransferase activity
I6G43_RS06895	COG1846	Transcriptional regulator
I6G43_RS06905	COG0025	NhaP-type Na H and K H
I6G43_RS06915	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6G43_RS06920	COG1242	4 iron, 4 sulfur cluster binding
I6G43_RS06930	COG2244	polysaccharide biosynthetic process
I6G43_RS06935	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G43_RS06960	COG2827	Endonuclease containing a URI domain
I6G43_RS06980	COG2827	Endonuclease containing a URI domain
I6G43_RS06985	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6G43_RS06990	COG1098	S1 RNA binding domain
I6G43_RS07005	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6G43_RS07010	COG0629	single-stranded DNA binding
I6G43_RS07015	COG0360	Binds together with S18 to 16S ribosomal RNA
I6G43_RS07025	COG0017	Asparaginyl-tRNA synthetase
I6G43_RS07030	COG0436	Aminotransferase
I6G43_RS07040	COG1846	Transcriptional regulator
I6G43_RS07060	COG0242	peptide deformylase activity
I6G43_RS07070	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6G43_RS07075	COG0488	(ABC) transporter
I6G43_RS07080	COG0617	tRNA 3'-terminal CCA addition
I6G43_RS07090	COG1307	EDD domain protein, DegV family
I6G43_RS07110	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6G43_RS07115	COG0492	ferredoxin-NADP+ reductase activity
I6G43_RS07125	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6G43_RS07135	COG0251	oxidation-reduction process
I6G43_RS07150	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6G43_RS07170	COG0463	Glycosyl transferase, family 2
I6G43_RS07175	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G43_RS07180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G43_RS07185	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6G43_RS07190	COG2384	SAM-dependent methyltransferase
I6G43_RS07195	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6G43_RS07200	COG0204	Acyl-transferase
I6G43_RS07220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G43_RS07240	COG0577	efflux transmembrane transporter activity
I6G43_RS07240	COG1136	(ABC) transporter
I6G43_RS07255	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6G43_RS07265	COG2302	S4 RNA-binding domain
I6G43_RS07280	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6G43_RS07300	COG1051	belongs to the nudix hydrolase family
I6G43_RS07305	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G43_RS07320	COG0768	penicillin binding
I6G43_RS07340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G43_RS07350	COG2731	YhcH YjgK YiaL family protein
I6G43_RS07355	COG0395	ABC-type sugar transport system, permease component
I6G43_RS07360	COG1175	transmembrane transport
I6G43_RS07380	COG3458	cephalosporin-C deacetylase activity
I6G43_RS07385	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6G43_RS07400	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G43_RS07405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G43_RS07425	COG2177	Part of the ABC transporter FtsEX involved in
I6G43_RS07430	COG2884	Cell division ATP-binding protein ftsE
I6G43_RS07440	COG0517	IMP dehydrogenase activity
I6G43_RS07460	COG4750	Nucleotidyl transferase
I6G43_RS07495	COG0740	serine-type endopeptidase activity
I6G43_RS07500	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6G43_RS07505	COG2131	deaminase
I6G43_RS07515	COG1307	EDD domain protein, DegV family
I6G43_RS07520	COG2081	HI0933 family
I6G43_RS07535	COG0519	Catalyzes the synthesis of GMP from XMP
I6G43_RS07545	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6G43_RS07575	COG1113	amino acid transport
I6G43_RS07585	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6G43_RS07610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G43_RS07615	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6G43_RS07620	COG0626	cystathionine gamma-synthase activity
I6G43_RS07625	COG4166	transmembrane transport
I6G43_RS07640	COG0438	transferase activity, transferring glycosyl groups
I6G43_RS07645	COG0438	transferase activity, transferring glycosyl groups
I6G43_RS07655	COG2723	6-phospho-beta-galactosidase activity
I6G43_RS07665	COG0653	protein targeting
I6G43_RS07685	COG0201	protein transport
I6G43_RS07690	COG3250	beta-galactosidase activity
I6G43_RS07695	COG0300	oxidoreductase activity
I6G43_RS07710	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6G43_RS07730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G43_RS07735	COG1940	carbohydrate kinase activity
I6G43_RS07745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6G43_RS07750	COG3064	Membrane
I6G43_RS07760	COG0789	Transcriptional regulator
I6G43_RS07765	COG0733	neurotransmitter:sodium symporter activity
I6G43_RS07770	COG1482	cell wall glycoprotein biosynthetic process
I6G43_RS07790	COG0028	Belongs to the TPP enzyme family
I6G43_RS07795	COG2217	Heavy metal translocating P-type atpase
I6G43_RS07815	COG0352	thiamine-phosphate diphosphorylase activity
I6G43_RS07830	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6G43_RS07850	COG0352	thiamine-phosphate diphosphorylase activity
I6G43_RS07855	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6G43_RS07865	COG1304	FMN binding
I6G43_RS07875	COG0765	amino acid transport
I6G43_RS07880	COG1126	abc transporter atp-binding protein
I6G43_RS07885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G43_RS07900	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6G43_RS07925	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I6G43_RS07930	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6G43_RS07935	COG1609	Transcriptional regulator
I6G43_RS07940	COG1063	alcohol dehydrogenase
I6G43_RS07960	COG1174	glycine betaine transport
I6G43_RS07965	COG0517	IMP dehydrogenase activity
I6G43_RS07965	COG1125	glycine betaine transport
I6G43_RS07980	COG0366	Alpha amylase catalytic
I6G43_RS07985	COG0395	ABC-type sugar transport system, permease component
I6G43_RS07990	COG1175	transmembrane transport
I6G43_RS07995	COG1653	transport
I6G43_RS08000	COG3345	alpha-galactosidase
I6G43_RS08005	COG2207	Transcriptional regulator
I6G43_RS08140	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G43_RS08175	COG4221	oxidoreductase activity
I6G43_RS08180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G43_RS08185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G43_RS08195	COG0504	CTP synthase activity
I6G43_RS08215	COG0525	valine-tRNA ligase activity
I6G43_RS08225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G43_RS08265	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6G43_RS08270	COG0195	Participates in both transcription termination and antitermination
I6G43_RS08295	COG1131	(ABC) transporter
I6G43_RS08300	COG0537	adenosine 5'-monophosphoramidase activity
I6G43_RS08315	COG0484	heat shock protein binding
I6G43_RS08330	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6G43_RS08355	COG0174	glutamine synthetase
I6G43_RS08360	COG0789	Transcriptional regulator
I6G43_RS08370	COG0126	phosphoglycerate kinase activity
I6G43_RS08395	COG1363	Peptidase, m42
I6G43_RS08400	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G43_RS08405	COG4605	iron ion homeostasis
I6G43_RS08410	COG4604	ABC transporter, ATP-binding protein
I6G43_RS08415	COG4607	ABC-type enterochelin transport system periplasmic component
I6G43_RS08425	COG1187	pseudouridine synthase activity
I6G43_RS08445	COG0517	IMP dehydrogenase activity
I6G43_RS08470	COG0366	Alpha amylase catalytic
I6G43_RS08480	COG0768	penicillin binding
I6G43_RS08485	COG4839	cell division protein FtsL
I6G43_RS08510	COG0386	Belongs to the glutathione peroxidase family
I6G43_RS08515	COG0366	Alpha amylase catalytic
I6G43_RS08585	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6G43_RS08590	COG1668	transmembrane transport
I6G43_RS08595	COG4152	abc transporter atp-binding protein
I6G43_RS08600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G43_RS08600	COG0072	phenylalanine-tRNA ligase activity
I6G43_RS08605	COG0456	acetyltransferase
I6G43_RS08620	COG0671	phosphoesterase, PA-phosphatase related
I6G43_RS08625	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I6G43_RS08635	COG0569	domain protein
I6G43_RS08640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G43_RS08645	COG4608	Belongs to the ABC transporter superfamily
I6G43_RS08650	COG0444	Belongs to the ABC transporter superfamily
I6G43_RS08655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G43_RS08660	COG0601	transmembrane transport
I6G43_RS08665	COG4166	transmembrane transport
I6G43_RS08675	COG1253	flavin adenine dinucleotide binding
I6G43_RS08690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6G43_RS08700	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6G43_RS08710	COG0742	ribosomal rna small subunit methyltransferase
I6G43_RS08725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G43_RS08730	COG1254	Belongs to the acylphosphatase family
I6G43_RS08740	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G43_RS08750	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G43_RS08755	COG3481	metal-dependent phosphohydrolase, HD sub domain
I6G43_RS08765	COG1564	THIamine pyrophosphokinase
I6G43_RS08775	COG1162	GTPase activity
I6G43_RS08800	COG0084	hydrolase, TatD family'
I6G43_RS08805	COG0531	amino acid
I6G43_RS08810	COG4166	transmembrane transport
I6G43_RS08820	COG0436	Aminotransferase
I6G43_RS08830	COG0589	response to stress
I6G43_RS08835	COG0561	phosphatase activity
I6G43_RS08840	COG0252	asparaginase activity
I6G43_RS08845	COG1609	Transcriptional regulator
I6G43_RS08860	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6G43_RS08860	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6G43_RS08870	COG0285	dihydrofolate synthase activity
I6G43_RS08875	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6G43_RS08880	COG1266	CAAX protease self-immunity
I6G43_RS08885	COG2252	PERMEase
I6G43_RS08890	COG0561	phosphatase activity
I6G43_RS08900	COG3715	PTS system
I6G43_RS08905	COG3716	PTS system mannose fructose sorbose family IID component
I6G43_RS08910	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6G43_RS08915	COG3579	cysteine-type endopeptidase activity
I6G43_RS08920	COG1187	pseudouridine synthase activity
I6G43_RS08925	COG2261	transglycosylase associated protein
I6G43_RS08930	COG2309	aminopeptidase activity
I6G43_RS08940	COG2176	DNA-directed DNA polymerase activity
I6G43_RS08945	COG2723	6-phospho-beta-galactosidase activity
I6G43_RS08955	COG0750	zinc metalloprotease
I6G43_RS08960	COG4589	Belongs to the CDS family
I6G43_RS08965	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6G43_RS08970	COG1126	abc transporter atp-binding protein
I6G43_RS08975	COG0765	amino acid transport
I6G43_RS08980	COG0765	amino acid transport
I6G43_RS08985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G43_RS09005	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I6G43_RS09020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6G43_RS09045	COG2255	four-way junction helicase activity
I6G43_RS09065	COG3279	Response regulator of the LytR AlgR family
I6G43_RS09090	COG0588	phosphoglycerate mutase activity
I6G43_RS09095	COG2848	UPF0210 protein
I6G43_RS09100	COG3830	Belongs to the UPF0237 family
I6G43_RS09110	COG0202	RNA polymerase activity
I6G43_RS09115	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6G43_RS09125	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G43_RS09130	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6G43_RS09140	COG0201	protein transport
I6G43_RS09155	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6G43_RS09180	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6G43_RS09200	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6G43_RS09210	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6G43_RS09225	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6G43_RS09260	COG0602	queuosine metabolic process