locus-tag	class	description
A0O21_RS00020	COG3041	Addiction module toxin RelE StbE family
A0O21_RS00050	COG1674	ftsk spoiiie
A0O21_RS00055	COG1511	domain protein
A0O21_RS00060	COG4842	Belongs to the WXG100 family
A0O21_RS00125	COG4842	Belongs to the WXG100 family
A0O21_RS00180	COG4842	Belongs to the WXG100 family
A0O21_RS00205	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A0O21_RS00220	COG1254	Belongs to the acylphosphatase family
A0O21_RS00225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A0O21_RS00280	COG0582	viral genome integration into host DNA
A0O21_RS00285	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A0O21_RS00295	COG1187	pseudouridine synthase activity
A0O21_RS00300	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A0O21_RS00310	COG0569	domain protein
A0O21_RS00335	COG1131	(ABC) transporter
A0O21_RS00350	COG0431	NADPH-dependent FMN reductase
A0O21_RS00350	COG1053	succinate dehydrogenase
A0O21_RS00350	COG3976	FMN-binding domain protein
A0O21_RS00360	COG2832	Protein of unknown function (DUF454)
A0O21_RS00365	COG0756	dUTP diphosphatase activity
A0O21_RS00385	COG1522	sequence-specific DNA binding
A0O21_RS00390	COG1335	isochorismatase
A0O21_RS00395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A0O21_RS00400	COG0137	argininosuccinate synthase activity
A0O21_RS00415	COG0594	ribonuclease P activity
A0O21_RS00445	COG0673	inositol 2-dehydrogenase activity
A0O21_RS00450	COG0084	hydrolase, TatD family'
A0O21_RS00500	COG2261	transglycosylase associated protein
A0O21_RS00545	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A0O21_RS00545	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A0O21_RS00545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0O21_RS00550	COG3684	Belongs to the aldolase LacD family
A0O21_RS00565	COG1882	Formate acetyltransferase
A0O21_RS00580	COG1846	Transcriptional regulator
A0O21_RS00580	COG0456	acetyltransferase
A0O21_RS00595	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A0O21_RS00615	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A0O21_RS00620	COG0681	Belongs to the peptidase S26 family
A0O21_RS00625	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A0O21_RS00660	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A0O21_RS00665	COG0789	Transcriptional regulator
A0O21_RS00665	COG4978	Transcriptional regulator
A0O21_RS00670	COG3118	belongs to the thioredoxin family
A0O21_RS00675	COG1194	a g-specific adenine glycosylase
A0O21_RS00685	COG0681	Belongs to the peptidase S26 family
A0O21_RS00720	COG1131	(ABC) transporter
A0O21_RS00730	COG1132	(ABC) transporter
A0O21_RS00755	COG3620	sequence-specific DNA binding
A0O21_RS00770	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A0O21_RS00805	COG0006	proline dipeptidase activity
A0O21_RS00810	COG2131	deaminase
A0O21_RS00815	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A0O21_RS00830	COG1621	beta-fructofuranosidase activity
A0O21_RS00835	COG1609	Transcriptional regulator
A0O21_RS00840	COG1621	beta-fructofuranosidase activity
A0O21_RS00845	COG2190	(PTS) system
A0O21_RS00845	COG1263	PTS System
A0O21_RS00845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A0O21_RS00850	COG1940	carbohydrate kinase activity
A0O21_RS00860	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A0O21_RS00865	COG2723	6-phospho-beta-galactosidase activity
A0O21_RS00870	COG1482	cell wall glycoprotein biosynthetic process
A0O21_RS00880	COG4152	abc transporter atp-binding protein
A0O21_RS00895	COG0653	protein targeting
A0O21_RS00900	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A0O21_RS00905	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A0O21_RS00910	COG0736	holo-[acyl-carrier-protein] synthase activity
A0O21_RS00920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A0O21_RS00925	COG4989	oxidoreductase activity
A0O21_RS00930	COG0561	phosphatase activity
A0O21_RS00935	COG0589	response to stress
A0O21_RS00940	COG0584	glycerophosphoryl diester phosphodiesterase
A0O21_RS00945	COG0436	Aminotransferase
A0O21_RS00955	COG1335	isochorismatase
A0O21_RS00965	COG0583	DNA-binding transcription factor activity
A0O21_RS00975	COG1073	alpha beta
A0O21_RS00985	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A0O21_RS00990	COG0154	amidase activity
A0O21_RS01005	COG0477	Major facilitator Superfamily
A0O21_RS01010	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A0O21_RS01015	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A0O21_RS01020	COG1534	Rna-binding protein
A0O21_RS01025	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A0O21_RS01030	COG1713	HD superfamily hydrolase involved in NAD metabolism
A0O21_RS01035	COG0799	negative regulation of ribosome biogenesis
A0O21_RS01040	COG2226	methyltransferase
A0O21_RS01045	COG1323	Belongs to the UPF0348 family
A0O21_RS01060	COG0217	transcriptional regulatory protein
A0O21_RS01065	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A0O21_RS01070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0O21_RS01075	COG1464	Belongs to the NlpA lipoprotein family
A0O21_RS01085	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A0O21_RS01100	COG4720	Psort location CytoplasmicMembrane, score
A0O21_RS01105	COG1122	ATPase activity
A0O21_RS01115	COG0569	domain protein
A0O21_RS01120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A0O21_RS01125	COG0357	Ribosomal RNA small subunit methyltransferase G
A0O21_RS01130	COG1704	LemA family
A0O21_RS01135	COG0501	Belongs to the peptidase M48B family
A0O21_RS01145	COG0745	RESPONSE REGULATOR receiver
A0O21_RS01150	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A0O21_RS01160	COG1484	DNA-dependent DNA replication
A0O21_RS01170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A0O21_RS01225	COG0195	Participates in both transcription termination and antitermination
A0O21_RS01230	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A0O21_RS01240	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A0O21_RS01245	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A0O21_RS01255	COG2217	Heavy metal translocating P-type atpase
A0O21_RS01265	COG0076	glutamate decarboxylase activity
A0O21_RS01280	COG0698	ribose 5-phosphate isomerase
A0O21_RS01285	COG1105	Belongs to the carbohydrate kinase PfkB family
A0O21_RS01295	COG1447	Phosphotransferase system cellobiose-specific component IIA
A0O21_RS01300	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A0O21_RS01300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A0O21_RS01305	COG2723	6-phospho-beta-galactosidase activity
A0O21_RS01310	COG0561	phosphatase activity
A0O21_RS01390	COG4224	UPF0291 protein
A0O21_RS01400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0O21_RS01400	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A0O21_RS01400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A0O21_RS01405	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A0O21_RS01410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A0O21_RS01435	COG3711	transcriptional antiterminator
A0O21_RS01455	COG3037	sugar-specific permease SgaT UlaA
A0O21_RS01510	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A0O21_RS01525	COG0768	penicillin binding
A0O21_RS01530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A0O21_RS01545	COG3290	protein histidine kinase activity
A0O21_RS01560	COG1876	peptidase activity
A0O21_RS01565	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A0O21_RS01570	COG1349	DNA-binding transcription factor activity
A0O21_RS01575	COG1882	Formate acetyltransferase
A0O21_RS01590	COG0513	Belongs to the DEAD box helicase family
A0O21_RS01610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A0O21_RS01625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A0O21_RS01645	COG4221	oxidoreductase activity
A0O21_RS01660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A0O21_RS01665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A0O21_RS01670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A0O21_RS01675	COG1120	ATPase activity
A0O21_RS01680	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A0O21_RS01685	COG2244	polysaccharide biosynthetic process
A0O21_RS01690	COG0626	cystathionine gamma-synthase activity
A0O21_RS01695	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A0O21_RS01705	COG1621	beta-fructofuranosidase activity
A0O21_RS01715	COG0740	serine-type endopeptidase activity
A0O21_RS01760	COG0583	DNA-binding transcription factor activity
A0O21_RS01770	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A0O21_RS01790	COG0517	IMP dehydrogenase activity
A0O21_RS01800	COG0470	DNA polymerase III
A0O21_RS01805	COG1774	PSP1 C-terminal conserved region
A0O21_RS01835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A0O21_RS01840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A0O21_RS01850	COG0708	Exodeoxyribonuclease III
A0O21_RS01860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A0O21_RS01860	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A0O21_RS01870	COG1028	Short-chain dehydrogenase reductase Sdr
A0O21_RS01920	COG1104	cysteine desulfurase activity
A0O21_RS01940	COG2843	Capsule synthesis protein
A0O21_RS01955	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A0O21_RS01960	COG0583	DNA-binding transcription factor activity
A0O21_RS01970	COG0564	pseudouridine synthase activity
A0O21_RS01985	COG0540	Belongs to the ATCase OTCase family
A0O21_RS01990	COG0505	Belongs to the CarA family
A0O21_RS01995	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A0O21_RS02005	COG1136	(ABC) transporter
A0O21_RS02010	COG0577	efflux transmembrane transporter activity
A0O21_RS02025	COG1837	Belongs to the UPF0109 family
A0O21_RS02035	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A0O21_RS02050	COG1349	DNA-binding transcription factor activity
A0O21_RS02055	COG1105	Belongs to the carbohydrate kinase PfkB family
A0O21_RS02060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A0O21_RS02060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A0O21_RS02060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0O21_RS02065	COG3942	CHAP domain
A0O21_RS02065	COG1705	Flagellar rod assembly protein muramidase FlgJ
A0O21_RS02165	COG2274	protein secretion by the type I secretion system
A0O21_RS02175	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A0O21_RS02180	COG0081	regulation of translation
A0O21_RS02240	COG0233	cytoplasmic translational termination
A0O21_RS02260	COG1702	phosphate starvation-inducible protein PhoH
A0O21_RS02265	COG1573	uracil-dna glycosylase
A0O21_RS02275	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A0O21_RS02280	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A0O21_RS02300	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A0O21_RS02305	COG0237	dephospho-CoA kinase activity
A0O21_RS02310	COG2814	Major facilitator Superfamily
A0O21_RS02320	COG0557	exoribonuclease II activity
A0O21_RS02335	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A0O21_RS02340	COG1846	Transcriptional regulator
A0O21_RS02355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A0O21_RS02360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A0O21_RS02360	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A0O21_RS02370	COG1737	Transcriptional regulator
A0O21_RS02410	COG1263	PTS System
A0O21_RS02410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A0O21_RS02410	COG2190	(PTS) system
A0O21_RS02415	COG2723	6-phospho-beta-galactosidase activity
A0O21_RS02420	COG0346	lactoylglutathione lyase activity
A0O21_RS02425	COG0778	Nitroreductase
A0O21_RS02430	COG1811	Na channel or pump
A0O21_RS02455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A0O21_RS02455	COG1263	PTS System
A0O21_RS02455	COG2190	(PTS) system
A0O21_RS02460	COG3394	polysaccharide catabolic process
A0O21_RS02465	COG0006	proline dipeptidase activity
A0O21_RS02470	COG1609	Transcriptional regulator
A0O21_RS02485	COG0438	transferase activity, transferring glycosyl groups
A0O21_RS02500	COG0745	RESPONSE REGULATOR receiver
A0O21_RS02510	COG1396	sequence-specific DNA binding
A0O21_RS02525	COG0765	amino acid transport
A0O21_RS02530	COG0765	amino acid transport
A0O21_RS02535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0O21_RS02540	COG1126	abc transporter atp-binding protein
A0O21_RS02545	COG0745	RESPONSE REGULATOR receiver
A0O21_RS02550	COG5002	protein histidine kinase activity
A0O21_RS02555	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A0O21_RS02560	COG0571	ribonuclease III activity
A0O21_RS02565	COG1196	nuclear chromosome segregation
A0O21_RS02570	COG0561	phosphatase activity
A0O21_RS02575	COG0561	phosphatase activity
A0O21_RS02580	COG0552	protein localization to endoplasmic reticulum
A0O21_RS02585	COG3689	TIGRFAM TIGR03943 family protein
A0O21_RS02590	COG0701	Predicted permease
A0O21_RS02595	COG2183	response to ionizing radiation
A0O21_RS02610	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A0O21_RS02615	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A0O21_RS02640	COG0826	peptidase U32
A0O21_RS02650	COG4443	Transcriptional Coactivator p15 (PC4)
A0O21_RS02655	COG1268	BioY protein
A0O21_RS02660	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A0O21_RS02675	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A0O21_RS02690	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A0O21_RS02705	COG0386	Belongs to the glutathione peroxidase family
A0O21_RS02715	COG0772	Belongs to the SEDS family
A0O21_RS02720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A0O21_RS02750	COG2348	transferase activity, transferring amino-acyl groups
A0O21_RS02760	COG1078	dGTPase activity
A0O21_RS02780	COG2204	response regulator
A0O21_RS02790	COG1454	alcohol dehydrogenase
A0O21_RS02795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A0O21_RS02800	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A0O21_RS02820	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A0O21_RS02830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A0O21_RS02835	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A0O21_RS02845	COG2884	Cell division ATP-binding protein ftsE
A0O21_RS02850	COG2177	Part of the ABC transporter FtsEX involved in
A0O21_RS02860	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A0O21_RS02885	COG0436	Aminotransferase
A0O21_RS02890	COG0017	Asparaginyl-tRNA synthetase
A0O21_RS02895	COG0251	oxidation-reduction process
A0O21_RS02915	COG0438	transferase activity, transferring glycosyl groups
A0O21_RS02930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A0O21_RS02935	COG1660	Displays ATPase and GTPase activities
A0O21_RS02990	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A0O21_RS03000	COG1215	transferase activity, transferring glycosyl groups
A0O21_RS03005	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A0O21_RS03010	COG4932	domain protein
A0O21_RS03020	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A0O21_RS03025	COG2153	protein acetylation
A0O21_RS03030	COG0625	glutathione transferase activity
A0O21_RS03035	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A0O21_RS03040	COG0716	FMN binding
A0O21_RS03055	COG1605	Chorismate mutase
A0O21_RS03055	COG0287	Prephenate dehydrogenase
A0O21_RS03070	COG0335	large ribosomal subunit rRNA binding
A0O21_RS03080	COG0772	Belongs to the SEDS family
A0O21_RS03110	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A0O21_RS03115	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A0O21_RS03120	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A0O21_RS03125	COG0560	Phosphoserine phosphatase
A0O21_RS03135	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A0O21_RS03145	COG0107	imidazoleglycerol-phosphate synthase activity
A0O21_RS03160	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A0O21_RS03180	COG2190	(PTS) system
A0O21_RS03180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A0O21_RS03180	COG1263	PTS System
A0O21_RS03185	COG0148	phosphopyruvate hydratase activity
A0O21_RS03190	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A0O21_RS03200	COG0077	Prephenate dehydratase
A0O21_RS03210	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A0O21_RS03250	COG1733	regulation of RNA biosynthetic process
A0O21_RS03270	COG0110	maltose O-acetyltransferase activity
A0O21_RS03275	COG0656	L-ascorbic acid biosynthetic process
A0O21_RS03280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A0O21_RS03295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A0O21_RS03305	COG0110	maltose O-acetyltransferase activity
A0O21_RS03310	COG0561	phosphatase activity
A0O21_RS03315	COG4989	oxidoreductase activity
A0O21_RS03325	COG0561	phosphatase activity
A0O21_RS03345	COG0488	(ABC) transporter
A0O21_RS03350	COG1126	abc transporter atp-binding protein
A0O21_RS03355	COG0765	amino acid transport
A0O21_RS03360	COG0556	nucleotide-excision repair
A0O21_RS03365	COG3842	ATPase activity
A0O21_RS03370	COG3833	ABC-type maltose transport systems, permease component
A0O21_RS03375	COG1175	transmembrane transport
A0O21_RS03385	COG1609	Transcriptional regulator
A0O21_RS03390	COG1640	4-alpha-glucanotransferase
A0O21_RS03395	COG0058	SHG alpha-glucan phosphorylase activity
A0O21_RS03405	COG0436	Aminotransferase
A0O21_RS03420	COG1970	mechanosensitive ion channel activity
A0O21_RS03425	COG0358	DNA primase activity
A0O21_RS03430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A0O21_RS03435	COG2151	metal-sulfur cluster biosynthetic enzyme
A0O21_RS03440	COG1091	dTDP-4-dehydrorhamnose reductase activity
A0O21_RS03450	COG1442	glycosyl transferase family 8
A0O21_RS03450	COG1216	Glycosyl transferase, family 2
A0O21_RS03475	COG1368	sulfuric ester hydrolase activity
A0O21_RS03485	COG0463	Glycosyl transferase, family 2
A0O21_RS03500	COG2195	Cleaves the N-terminal amino acid of tripeptides
A0O21_RS03525	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A0O21_RS03530	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A0O21_RS03535	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A0O21_RS03540	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
A0O21_RS03550	COG1368	sulfuric ester hydrolase activity
A0O21_RS03555	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A0O21_RS03565	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A0O21_RS03570	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A0O21_RS03580	COG0287	Prephenate dehydrogenase
A0O21_RS03595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A0O21_RS03600	COG0285	dihydrofolate synthase activity
A0O21_RS03605	COG0463	Glycosyl transferase, family 2
A0O21_RS03640	COG0488	(ABC) transporter
A0O21_RS03655	COG1132	(ABC) transporter
A0O21_RS03670	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A0O21_RS03690	COG1132	(ABC) transporter
A0O21_RS03705	COG1732	Glycine betaine
A0O21_RS03720	COG2357	RelA SpoT domain protein
A0O21_RS03725	COG0745	RESPONSE REGULATOR receiver
A0O21_RS03735	COG0583	DNA-binding transcription factor activity
A0O21_RS03745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0O21_RS03750	COG0765	amino acid transport
A0O21_RS03755	COG0765	amino acid transport
A0O21_RS03760	COG1126	abc transporter atp-binding protein
A0O21_RS03785	COG1304	FMN binding
A0O21_RS03790	COG1272	protein, Hemolysin III
A0O21_RS03805	COG3425	synthase
A0O21_RS03825	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A0O21_RS03840	COG0833	amino acid
A0O21_RS03845	COG2040	homocysteine
A0O21_RS03875	COG0464	growth
A0O21_RS03900	COG0667	Aldo Keto reductase
A0O21_RS03925	COG1028	Short-chain dehydrogenase reductase Sdr
A0O21_RS03935	COG0667	Aldo Keto reductase
A0O21_RS03950	COG0726	polysaccharide deacetylase
A0O21_RS03960	COG0083	homoserine kinase activity
A0O21_RS03965	COG0285	dihydrofolate synthase activity
A0O21_RS03985	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A0O21_RS03990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A0O21_RS04000	COG1176	ABC-type spermidine putrescine transport system, permease component I
A0O21_RS04015	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A0O21_RS04020	COG3711	transcriptional antiterminator
A0O21_RS04025	COG1263	PTS System
A0O21_RS04025	COG2190	(PTS) system
A0O21_RS04025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A0O21_RS04035	COG2272	Belongs to the type-B carboxylesterase lipase family
A0O21_RS04040	COG1917	Cupin 2, conserved barrel domain protein
A0O21_RS04040	COG4977	sequence-specific DNA binding
A0O21_RS04050	COG0702	epimerase
A0O21_RS04095	COG0494	nUDIX hydrolase
A0O21_RS04130	COG0583	DNA-binding transcription factor activity
A0O21_RS04180	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A0O21_RS04185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0O21_RS04185	COG3711	transcriptional antiterminator
A0O21_RS04190	COG1447	Phosphotransferase system cellobiose-specific component IIA
A0O21_RS04200	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A0O21_RS04215	COG2723	6-phospho-beta-galactosidase activity
A0O21_RS04220	COG0561	phosphatase activity
A0O21_RS04230	COG0561	phosphatase activity
A0O21_RS04245	COG2723	6-phospho-beta-galactosidase activity
A0O21_RS04250	COG0628	permease
A0O21_RS04255	COG1442	glycosyl transferase family 8
A0O21_RS04265	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A0O21_RS04270	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A0O21_RS04280	COG1104	cysteine desulfurase activity
A0O21_RS04295	COG2357	RelA SpoT domain protein
A0O21_RS04305	COG0564	pseudouridine synthase activity
A0O21_RS04310	COG0280	phosphate acetyltransferase
A0O21_RS04315	COG4221	oxidoreductase activity
A0O21_RS04330	COG2723	6-phospho-beta-galactosidase activity
A0O21_RS04350	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A0O21_RS04355	COG2890	protein-(glutamine-N5) methyltransferase activity
A0O21_RS04360	COG0009	L-threonylcarbamoyladenylate synthase
A0O21_RS04400	COG1132	(ABC) transporter
A0O21_RS04405	COG2239	Acts as a magnesium transporter
A0O21_RS04415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A0O21_RS04420	COG4684	Psort location CytoplasmicMembrane, score
A0O21_RS04425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A0O21_RS04445	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A0O21_RS04455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A0O21_RS04460	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A0O21_RS04465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A0O21_RS04470	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A0O21_RS04470	COG1328	CTP reductase activity
A0O21_RS04475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A0O21_RS04480	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A0O21_RS04500	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A0O21_RS04505	COG0758	DNA mediated transformation
A0O21_RS04510	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A0O21_RS04515	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A0O21_RS04525	COG1136	(ABC) transporter
A0O21_RS04535	COG0745	RESPONSE REGULATOR receiver
A0O21_RS04540	COG0642	Histidine kinase
A0O21_RS04545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A0O21_RS04555	COG4974	Belongs to the 'phage' integrase family
A0O21_RS04575	COG1028	Short-chain dehydrogenase reductase Sdr
A0O21_RS04580	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A0O21_RS04580	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0O21_RS04590	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A0O21_RS04600	COG3716	PTS system mannose fructose sorbose family IID component
A0O21_RS04605	COG1609	Transcriptional regulator
A0O21_RS04625	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A0O21_RS04630	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
A0O21_RS04640	COG2188	Transcriptional regulator
A0O21_RS04650	COG0519	Catalyzes the synthesis of GMP from XMP
A0O21_RS04670	COG0346	lactoylglutathione lyase activity
A0O21_RS04675	COG3764	Sortase (surface protein transpeptidase)
A0O21_RS04695	COG1079	Belongs to the binding-protein-dependent transport system permease family
A0O21_RS04700	COG4603	Belongs to the binding-protein-dependent transport system permease family
A0O21_RS04705	COG3845	ABC transporter
A0O21_RS04710	COG1744	ABC transporter substrate-binding protein PnrA-like
A0O21_RS04715	COG0295	cytidine deaminase activity
A0O21_RS04730	COG2813	Specifically methylates the guanine in position
A0O21_RS04735	COG1072	(Pantothenic acid kinase))
A0O21_RS04740	COG0268	Binds directly to 16S ribosomal RNA
A0O21_RS04745	COG5002	protein histidine kinase activity
A0O21_RS04750	COG0745	RESPONSE REGULATOR receiver
A0O21_RS04760	COG0704	Plays a role in the regulation of phosphate uptake
A0O21_RS04765	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A0O21_RS04770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A0O21_RS04775	COG0581	inorganic phosphate transmembrane transporter activity
A0O21_RS04780	COG0573	inorganic phosphate transmembrane transporter activity
A0O21_RS04790	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A0O21_RS04790	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A0O21_RS04795	COG0483	inositol monophosphate 1-phosphatase activity
A0O21_RS04800	COG4476	Belongs to the UPF0223 family
A0O21_RS04805	COG1393	Belongs to the ArsC family
A0O21_RS04810	COG0196	riboflavin kinase activity
A0O21_RS04815	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A0O21_RS04820	COG0366	Alpha amylase catalytic
A0O21_RS04820	COG5263	repeat protein
A0O21_RS04885	COG4129	membrane
A0O21_RS04895	COG1230	cation diffusion facilitator family transporter
A0O21_RS04910	COG2873	o-acetylhomoserine
A0O21_RS04925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A0O21_RS04930	COG1115	amino acid carrier protein
A0O21_RS04935	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A0O21_RS04945	COG1126	abc transporter atp-binding protein
A0O21_RS04950	COG0765	amino acid transport
A0O21_RS04955	COG0246	Mannitol dehydrogenase
A0O21_RS04960	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0O21_RS04965	COG3711	transcriptional antiterminator
A0O21_RS04970	COG2213	PTS system mannitol-specific
A0O21_RS04980	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A0O21_RS04990	COG0469	pyruvate kinase activity
A0O21_RS04995	COG0205	6-phosphofructokinase activity
A0O21_RS05005	COG1725	Transcriptional regulator
A0O21_RS05010	COG1131	(ABC) transporter
A0O21_RS05020	COG0398	Pfam SNARE associated Golgi protein
A0O21_RS05040	COG0539	negative regulation of cytoplasmic translation
A0O21_RS05060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A0O21_RS05075	COG0187	DNA topoisomerase II activity
A0O21_RS05085	COG0737	Belongs to the 5'-nucleotidase family
A0O21_RS05095	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A0O21_RS05110	COG1881	PFAM PEBP family protein
A0O21_RS05125	COG0284	orotidine-5'-phosphate decarboxylase activity
A0O21_RS05130	COG0167	dihydroorotate dehydrogenase activity
A0O21_RS05150	COG4598	ABC transporter
A0O21_RS05160	COG0438	transferase activity, transferring glycosyl groups
A0O21_RS05165	COG0438	transferase activity, transferring glycosyl groups
A0O21_RS05175	COG1216	Glycosyl transferase, family 2
A0O21_RS05175	COG1442	glycosyl transferase family 8
A0O21_RS05190	COG0562	UDP-galactopyranose mutase
A0O21_RS05195	COG2244	polysaccharide biosynthetic process
A0O21_RS05215	COG1316	TRANSCRIPTIONal
A0O21_RS05220	COG0583	DNA-binding transcription factor activity
A0O21_RS05245	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A0O21_RS05260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A0O21_RS05305	COG0322	excinuclease ABC activity
A0O21_RS05310	COG1012	belongs to the aldehyde dehydrogenase family
A0O21_RS05320	COG0702	epimerase
A0O21_RS05325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A0O21_RS05330	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A0O21_RS05340	COG1733	regulation of RNA biosynthetic process
A0O21_RS05375	COG0492	ferredoxin-NADP+ reductase activity
A0O21_RS05380	COG3118	belongs to the thioredoxin family
A0O21_RS05385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A0O21_RS05390	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A0O21_RS05415	COG0656	L-ascorbic acid biosynthetic process
A0O21_RS05420	COG0656	L-ascorbic acid biosynthetic process
A0O21_RS05430	COG0656	L-ascorbic acid biosynthetic process
A0O21_RS05435	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A0O21_RS05510	COG0583	DNA-binding transcription factor activity
A0O21_RS05515	COG1902	pentaerythritol trinitrate reductase activity
A0O21_RS05525	COG4948	Mandelate Racemase Muconate Lactonizing
A0O21_RS05530	COG3775	system Galactitol-specific IIC component
A0O21_RS05535	COG3414	Phosphotransferase system galactitol-specific IIB component
A0O21_RS05555	COG0481	GTPase activity
A0O21_RS05590	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
A0O21_RS05595	COG1518	maintenance of DNA repeat elements
A0O21_RS05600	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
A0O21_RS05615	COG0647	UMP catabolic process
A0O21_RS05625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A0O21_RS05635	COG2249	NAD(P)H dehydrogenase (quinone) activity
A0O21_RS05640	COG2176	DNA-directed DNA polymerase activity
A0O21_RS05645	COG1518	maintenance of DNA repeat elements
A0O21_RS05660	COG1857	crispr-associated protein
A0O21_RS05695	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A0O21_RS05700	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A0O21_RS05705	COG3442	glutamine amidotransferase
A0O21_RS05715	COG1780	Probably involved in ribonucleotide reductase function
A0O21_RS05720	COG1846	Transcriptional regulator
A0O21_RS05730	COG0095	Lipoate-protein ligase
A0O21_RS05735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A0O21_RS05740	COG0508	dehydrogenase complex catalyzes the overall conversion of
A0O21_RS05745	COG0508	dehydrogenase complex catalyzes the overall conversion of
A0O21_RS05745	COG0022	dehydrogenase e1 component
A0O21_RS05750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A0O21_RS05755	COG0488	(ABC) transporter
A0O21_RS05780	COG1136	(ABC) transporter
A0O21_RS05780	COG0577	efflux transmembrane transporter activity
A0O21_RS05815	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A0O21_RS05820	COG3527	Alpha-acetolactate decarboxylase
A0O21_RS05825	COG0028	Belongs to the TPP enzyme family
A0O21_RS05835	COG0628	permease
A0O21_RS05840	COG1051	belongs to the nudix hydrolase family
A0O21_RS05845	COG2706	6-phosphogluconolactonase activity
A0O21_RS05850	COG1088	dTDP-glucose 4,6-dehydratase activity
A0O21_RS05865	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A0O21_RS05900	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A0O21_RS05905	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A0O21_RS05905	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A0O21_RS05910	COG0300	oxidoreductase activity
A0O21_RS05920	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A0O21_RS05925	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A0O21_RS05965	COG0686	Belongs to the AlaDH PNT family
A0O21_RS05970	COG2267	carboxylic ester hydrolase activity
A0O21_RS05990	COG1074	ATP-dependent DNA helicase activity
A0O21_RS05995	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A0O21_RS06000	COG0072	phenylalanine-tRNA ligase activity
A0O21_RS06000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A0O21_RS06010	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A0O21_RS06025	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A0O21_RS06060	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A0O21_RS06075	COG0058	SHG alpha-glucan phosphorylase activity
A0O21_RS06080	COG0297	glycogen (starch) synthase activity
A0O21_RS06085	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A0O21_RS06090	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A0O21_RS06095	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A0O21_RS06100	COG1523	belongs to the glycosyl hydrolase 13 family
A0O21_RS06105	COG1597	lipid kinase activity
A0O21_RS06110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A0O21_RS06115	COG0561	phosphatase activity
A0O21_RS06120	COG4708	membrane
A0O21_RS06135	COG4109	DRTGG domain
A0O21_RS06140	COG0519	Catalyzes the synthesis of GMP from XMP
A0O21_RS06160	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A0O21_RS06175	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A0O21_RS06180	COG1956	GAF domain-containing protein
A0O21_RS06195	COG3340	Belongs to the peptidase S51 family
A0O21_RS06205	COG0066	3-isopropylmalate dehydratase activity
A0O21_RS06210	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A0O21_RS06290	COG3052	prosthetic group binding
A0O21_RS06295	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
A0O21_RS06300	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A0O21_RS06330	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A0O21_RS06335	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A0O21_RS06345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A0O21_RS06350	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A0O21_RS06355	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A0O21_RS06360	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A0O21_RS06370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A0O21_RS06375	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A0O21_RS06385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A0O21_RS06390	COG4122	O-methyltransferase activity
A0O21_RS06405	COG0363	glucosamine-6-phosphate deaminase activity
A0O21_RS06415	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A0O21_RS06445	COG3426	butyrate kinase activity
A0O21_RS06450	COG0280	phosphate acetyltransferase
A0O21_RS06470	COG2508	Transcriptional regulator
A0O21_RS06475	COG1053	succinate dehydrogenase
A0O21_RS06500	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A0O21_RS06515	COG2333	competence protein COMEC
A0O21_RS06515	COG0658	competence protein
A0O21_RS06520	COG1555	photosystem II stabilization
A0O21_RS06520	COG1596	polysaccharide export
A0O21_RS06525	COG0204	Acyl-transferase
A0O21_RS06530	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A0O21_RS06535	COG0513	Belongs to the DEAD box helicase family
A0O21_RS06550	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A0O21_RS06565	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A0O21_RS06570	COG0768	penicillin binding
A0O21_RS06575	COG0588	phosphoglycerate mutase activity
A0O21_RS06590	COG0776	regulation of translation
A0O21_RS06595	COG4698	Protein conserved in bacteria
A0O21_RS06600	COG2755	lipolytic protein G-D-S-L family
A0O21_RS06610	COG0497	DNA recombination
A0O21_RS06615	COG1438	arginine binding
A0O21_RS06620	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A0O21_RS06635	COG1570	exodeoxyribonuclease VII activity
A0O21_RS06640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A0O21_RS06650	COG1918	ferrous iron import across plasma membrane
A0O21_RS06650	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A0O21_RS06660	COG1126	abc transporter atp-binding protein
A0O21_RS06665	COG0765	amino acid transport
A0O21_RS06670	COG4703	Protein of unknown function (DUF1797)
A0O21_RS06675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A0O21_RS06680	COG0542	response to heat
A0O21_RS06690	COG0494	nUDIX hydrolase
A0O21_RS06705	COG3599	regulation of cell shape
A0O21_RS06710	COG2302	S4 RNA-binding domain
A0O21_RS06720	COG1799	cell septum assembly
A0O21_RS06725	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A0O21_RS06745	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A0O21_RS06760	COG1217	gtp-binding protein TYPA
A0O21_RS06770	COG1940	carbohydrate kinase activity
A0O21_RS06785	COG0783	Belongs to the Dps family
A0O21_RS06795	COG0159	tryptophan synthase activity
A0O21_RS06800	COG0133	tryptophan synthase activity
A0O21_RS06805	COG0135	phosphoribosylanthranilate isomerase activity
A0O21_RS06810	COG0134	indole-3-glycerol-phosphate synthase activity
A0O21_RS06820	COG0512	Glutamine amidotransferase of anthranilate synthase
A0O21_RS06825	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A0O21_RS06835	COG2197	response regulator
A0O21_RS06845	COG4585	Histidine kinase
A0O21_RS06855	COG1131	(ABC) transporter
A0O21_RS06875	COG1132	(ABC) transporter
A0O21_RS06880	COG1132	(ABC) transporter
A0O21_RS06890	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A0O21_RS06895	COG4470	Protein conserved in bacteria
A0O21_RS06900	COG0737	Belongs to the 5'-nucleotidase family
A0O21_RS06910	COG3480	Lon protease (S16) C-terminal proteolytic domain
A0O21_RS06915	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A0O21_RS06920	COG0742	ribosomal rna small subunit methyltransferase
A0O21_RS06950	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A0O21_RS06950	COG0456	acetyltransferase
A0O21_RS06960	COG0525	valine-tRNA ligase activity
A0O21_RS07015	COG3716	PTS system mannose fructose sorbose family IID component
A0O21_RS07020	COG2188	Transcriptional regulator
A0O21_RS07035	COG2223	nitrite transmembrane transporter activity
A0O21_RS07040	COG2851	Citrate transporter
A0O21_RS07050	COG0710	3-dehydroquinate dehydratase activity
A0O21_RS07055	COG0738	Major facilitator superfamily
A0O21_RS07060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A0O21_RS07065	COG0738	Major facilitator superfamily
A0O21_RS07070	COG0583	DNA-binding transcription factor activity
A0O21_RS07075	COG1902	pentaerythritol trinitrate reductase activity
A0O21_RS07085	COG2137	regulation of response to DNA damage stimulus
A0O21_RS07090	COG3557	Belongs to the UPF0374 family
A0O21_RS07155	COG1040	competence protein
A0O21_RS07160	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A0O21_RS07165	COG1739	Uncharacterized protein family UPF0029
A0O21_RS07175	COG1185	polyribonucleotide nucleotidyltransferase activity
A0O21_RS07185	COG2197	response regulator
A0O21_RS07195	COG4585	Histidine kinase
A0O21_RS07205	COG0515	serine threonine protein kinase
A0O21_RS07205	COG2815	serine threonine protein kinase
A0O21_RS07215	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A0O21_RS07215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A0O21_RS07225	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A0O21_RS07230	COG1758	RNA polymerase activity
A0O21_RS07235	COG0194	GDP metabolic process
A0O21_RS07245	COG4372	Transposase
A0O21_RS07245	COG1418	mRNA catabolic process
A0O21_RS07250	COG1854	S-ribosylhomocysteine lyase activity
A0O21_RS07260	COG0116	Belongs to the methyltransferase superfamily
A0O21_RS07270	COG3599	regulation of cell shape
A0O21_RS07285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A0O21_RS07290	COG3579	cysteine-type endopeptidase activity
A0O21_RS07300	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A0O21_RS07305	COG0492	ferredoxin-NADP+ reductase activity
A0O21_RS07315	COG1126	abc transporter atp-binding protein
A0O21_RS07320	COG0765	amino acid transport
A0O21_RS07325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0O21_RS07350	COG4473	ABC transporter
A0O21_RS07355	COG1131	(ABC) transporter
A0O21_RS07360	COG0537	adenosine 5'-monophosphoramidase activity
A0O21_RS07370	COG1316	TRANSCRIPTIONal
A0O21_RS07385	COG2252	PERMEase
A0O21_RS07395	COG0561	phosphatase activity
A0O21_RS07405	COG3715	PTS system
A0O21_RS07410	COG3716	PTS system mannose fructose sorbose family IID component
A0O21_RS07450	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A0O21_RS07455	COG0439	Biotin carboxylase
A0O21_RS07460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A0O21_RS07470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A0O21_RS07475	COG1028	Short-chain dehydrogenase reductase Sdr
A0O21_RS07480	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A0O21_RS07485	COG2070	2-Nitropropane dioxygenase
A0O21_RS07495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A0O21_RS07505	COG1024	Enoyl-CoA hydratase
A0O21_RS07510	COG0527	aspartate kinase activity
A0O21_RS07580	COG1028	Short-chain dehydrogenase reductase Sdr
A0O21_RS07585	COG0596	Alpha beta hydrolase
A0O21_RS07590	COG3321	synthase
A0O21_RS07590	COG1028	Short-chain dehydrogenase reductase Sdr
A0O21_RS07590	COG0604	alcohol dehydrogenase
A0O21_RS07600	COG4608	Belongs to the ABC transporter superfamily
A0O21_RS07605	COG0444	Belongs to the ABC transporter superfamily
A0O21_RS07610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A0O21_RS07615	COG0601	transmembrane transport
A0O21_RS07620	COG4166	transmembrane transport
A0O21_RS07625	COG1686	Belongs to the peptidase S11 family
A0O21_RS07635	COG0719	Fe-S assembly protein
A0O21_RS07645	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A0O21_RS07650	COG0719	Fe-S assembly protein
A0O21_RS07660	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A0O21_RS07675	COG1263	PTS System
A0O21_RS07675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A0O21_RS07675	COG2190	(PTS) system
A0O21_RS07680	COG0698	ribose 5-phosphate isomerase
A0O21_RS07685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A0O21_RS07690	COG1609	Transcriptional regulator
A0O21_RS07705	COG0765	amino acid transport
A0O21_RS07710	COG1126	abc transporter atp-binding protein
A0O21_RS07750	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A0O21_RS07765	COG0501	Belongs to the peptidase M48B family
A0O21_RS07775	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A0O21_RS07780	COG0440	acetolactate synthase activity
A0O21_RS07785	COG0028	Belongs to the TPP enzyme family
A0O21_RS07790	COG1461	Dihydroxyacetone kinase
A0O21_RS07800	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A0O21_RS07840	COG0504	CTP synthase activity
A0O21_RS07860	COG0668	transmembrane transport
A0O21_RS07865	COG4475	Protein of unknown function (DUF436)
A0O21_RS07875	COG0351	phosphomethylpyrimidine kinase
A0O21_RS07880	COG0101	tRNA pseudouridine synthase activity
A0O21_RS07905	COG1705	Flagellar rod assembly protein muramidase FlgJ
A0O21_RS07910	COG1876	peptidase activity
A0O21_RS07925	COG3830	Belongs to the UPF0237 family
A0O21_RS07970	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A0O21_RS07975	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A0O21_RS07980	COG0071	Belongs to the small heat shock protein (HSP20) family
A0O21_RS07990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A0O21_RS07995	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A0O21_RS08010	COG1045	serine acetyltransferase
A0O21_RS08020	COG1185	polyribonucleotide nucleotidyltransferase activity
A0O21_RS08025	COG1454	alcohol dehydrogenase
A0O21_RS08025	COG1012	belongs to the aldehyde dehydrogenase family
A0O21_RS08035	COG0242	peptide deformylase activity
A0O21_RS08050	COG1846	Transcriptional regulator
A0O21_RS08055	COG2176	DNA-directed DNA polymerase activity
A0O21_RS08070	COG4589	Belongs to the CDS family
A0O21_RS08075	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A0O21_RS08080	COG1862	Preprotein translocase
A0O21_RS08090	COG0495	leucyl-tRNA aminoacylation
A0O21_RS08125	COG4932	domain protein
A0O21_RS08125	COG4932	domain protein
A0O21_RS08130	COG0343	queuine tRNA-ribosyltransferase activity
A0O21_RS08140	COG1832	CoA-binding protein
A0O21_RS08150	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A0O21_RS08150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A0O21_RS08170	COG3448	diguanylate cyclase activity
A0O21_RS08170	COG4175	Glycine betaine
A0O21_RS08180	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A0O21_RS08190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0O21_RS08190	COG3711	transcriptional antiterminator
A0O21_RS08200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A0O21_RS08225	COG3711	transcriptional antiterminator
A0O21_RS08235	COG3623	hexulose-6-phosphate isomerase
A0O21_RS08265	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A0O21_RS08275	COG3775	system Galactitol-specific IIC component
A0O21_RS08280	COG3414	Phosphotransferase system galactitol-specific IIB component
A0O21_RS08290	COG3711	transcriptional antiterminator
A0O21_RS08290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0O21_RS08300	COG1181	Belongs to the D-alanine--D-alanine ligase family
A0O21_RS08300	COG2918	glutathione biosynthetic process
A0O21_RS08320	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A0O21_RS08325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A0O21_RS08330	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A0O21_RS08335	COG3942	CHAP domain
A0O21_RS08335	COG1705	Flagellar rod assembly protein muramidase FlgJ
A0O21_RS08455	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A0O21_RS08460	COG5002	protein histidine kinase activity
A0O21_RS08465	COG0745	RESPONSE REGULATOR receiver
A0O21_RS08485	COG2151	metal-sulfur cluster biosynthetic enzyme
A0O21_RS08490	COG0419	ATPase involved in DNA repair
A0O21_RS08500	COG0129	dihydroxy-acid dehydratase activity
A0O21_RS08505	COG2081	HI0933 family
A0O21_RS08520	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A0O21_RS08530	COG3414	Phosphotransferase system galactitol-specific IIB component
A0O21_RS08535	COG3775	system Galactitol-specific IIC component
A0O21_RS08545	COG1349	DNA-binding transcription factor activity
A0O21_RS08565	COG5503	Protein of unknown function (DUF1447)
A0O21_RS08575	COG3942	CHAP domain
A0O21_RS08580	COG0174	glutamine synthetase
A0O21_RS08585	COG0789	Transcriptional regulator
A0O21_RS08595	COG0126	phosphoglycerate kinase activity
A0O21_RS08605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A0O21_RS08610	COG0049	tRNA binding
A0O21_RS08615	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A0O21_RS08620	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A0O21_RS08655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A0O21_RS08660	COG2274	protein secretion by the type I secretion system
A0O21_RS08705	COG0789	Transcriptional regulator
A0O21_RS08715	COG2017	converts alpha-aldose to the beta-anomer
A0O21_RS08730	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A0O21_RS08735	COG1253	flavin adenine dinucleotide binding
A0O21_RS08740	COG1119	ATPase activity
A0O21_RS08745	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A0O21_RS08750	COG1242	4 iron, 4 sulfur cluster binding
A0O21_RS08755	COG0671	phosphoesterase, PA-phosphatase related
A0O21_RS08760	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A0O21_RS08765	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A0O21_RS08770	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A0O21_RS08775	COG0457	Tetratricopeptide repeat
A0O21_RS08775	COG0705	Rhomboid family
A0O21_RS08780	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A0O21_RS08785	COG1473	amidohydrolase
A0O21_RS08795	COG1472	Belongs to the glycosyl hydrolase 3 family
A0O21_RS08810	COG3732	PTS system glucitol sorbitol-specific
A0O21_RS08815	COG3730	PTS system glucitol sorbitol-specific
A0O21_RS08825	COG3711	transcriptional antiterminator
A0O21_RS08825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0O21_RS08835	COG0166	Belongs to the GPI family
A0O21_RS08870	COG1234	tRNA 3'-trailer cleavage
A0O21_RS08875	COG0542	response to heat
A0O21_RS08880	COG4463	regulation of RNA biosynthetic process
A0O21_RS08895	COG0052	Belongs to the universal ribosomal protein uS2 family
A0O21_RS08905	COG3655	Transcriptional regulator
A0O21_RS08915	COG1132	(ABC) transporter
A0O21_RS08925	COG3177	Filamentation induced by cAMP protein fic
A0O21_RS08930	COG3590	peptidase
A0O21_RS08935	COG0366	Alpha amylase catalytic
A0O21_RS08940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A0O21_RS08940	COG1263	PTS System
A0O21_RS08945	COG2188	Transcriptional regulator
A0O21_RS08950	COG5002	protein histidine kinase activity
A0O21_RS08970	COG1131	(ABC) transporter
A0O21_RS08985	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A0O21_RS09005	COG1136	(ABC) transporter
A0O21_RS09010	COG0318	PFAM AMP-dependent synthetase and ligase
A0O21_RS09025	COG1131	(ABC) transporter
A0O21_RS09035	COG4106	trans-aconitate 2-methyltransferase activity
A0O21_RS09055	COG1396	sequence-specific DNA binding
A0O21_RS09060	COG1490	D-aminoacyl-tRNA deacylase activity
A0O21_RS09145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A0O21_RS09145	COG1263	PTS System
A0O21_RS09145	COG2190	(PTS) system
A0O21_RS09155	COG1609	Transcriptional regulator
A0O21_RS09160	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A0O21_RS09165	COG2264	protein methyltransferase activity
A0O21_RS09175	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A0O21_RS09195	COG4932	domain protein
A0O21_RS09195	COG1388	LysM domain
A0O21_RS09205	COG4932	domain protein
A0O21_RS09205	COG1388	LysM domain
A0O21_RS09215	COG2957	Belongs to the agmatine deiminase family
A0O21_RS09220	COG0531	amino acid
A0O21_RS09225	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A0O21_RS09230	COG2197	response regulator
A0O21_RS09235	COG3022	response to hydroperoxide
A0O21_RS09240	COG0602	queuosine metabolic process
A0O21_RS09255	COG1328	CTP reductase activity
A0O21_RS09275	COG4472	Bacterial protein of unknown function (DUF965)
A0O21_RS09290	COG1393	Belongs to the ArsC family
A0O21_RS09295	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A0O21_RS09300	COG1058	Belongs to the CinA family
A0O21_RS09300	COG1546	Belongs to the CinA family
A0O21_RS09305	COG0519	Catalyzes the synthesis of GMP from XMP
A0O21_RS09320	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A0O21_RS09340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A0O21_RS09345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A0O21_RS09370	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A0O21_RS09375	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A0O21_RS09395	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
A0O21_RS09400	COG3620	sequence-specific DNA binding
A0O21_RS09405	COG3177	Filamentation induced by cAMP protein fic
A0O21_RS09425	COG0300	oxidoreductase activity
A0O21_RS09440	COG0640	Transcriptional regulator
A0O21_RS09470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A0O21_RS09480	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A0O21_RS09490	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A0O21_RS09500	COG0305	Participates in initiation and elongation during chromosome replication
A0O21_RS09515	COG0445	tRNA wobble uridine modification
A0O21_RS09530	COG0741	lytic transglycosylase activity
A0O21_RS09540	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A0O21_RS09565	COG0612	Peptidase, M16
A0O21_RS09590	COG0516	GMP reductase activity
A0O21_RS09590	COG0517	IMP dehydrogenase activity
A0O21_RS09600	COG0488	(ABC) transporter
A0O21_RS09625	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A0O21_RS09630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A0O21_RS09635	COG1475	DNA binding
A0O21_RS09645	COG0592	DNA-directed DNA polymerase activity
A0O21_RS09660	COG1476	TRANSCRIPTIONal
A0O21_RS09675	COG3620	sequence-specific DNA binding
A0O21_RS09680	COG0012	GTP binding
A0O21_RS09690	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A0O21_RS09695	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A0O21_RS09720	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A0O21_RS09725	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A0O21_RS09835	COG1792	Involved in formation and maintenance of cell shape
A0O21_RS09870	COG0436	Aminotransferase
A0O21_RS09880	COG0416	fatty acid biosynthetic process
A0O21_RS09885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A0O21_RS09890	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A0O21_RS09895	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A0O21_RS09900	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A0O21_RS09905	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A0O21_RS09910	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A0O21_RS09945	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0O21_RS09950	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A0O21_RS09955	COG3715	PTS system
A0O21_RS09960	COG3716	PTS system mannose fructose sorbose family IID component
A0O21_RS09965	COG1979	alcohol dehydrogenase
A0O21_RS09980	COG5632	N-Acetylmuramoyl-L-alanine amidase
A0O21_RS09980	COG3409	Peptidoglycan-binding domain 1 protein
A0O21_RS09985	COG0151	Belongs to the GarS family
A0O21_RS09990	COG1683	Conserved Protein
A0O21_RS09995	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A0O21_RS10005	COG1794	racemase activity, acting on amino acids and derivatives
A0O21_RS10020	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A0O21_RS10025	COG3976	FMN-binding domain protein
A0O21_RS10025	COG1053	succinate dehydrogenase
A0O21_RS10035	COG2255	four-way junction helicase activity
A0O21_RS10055	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A0O21_RS10055	COG2755	lipolytic protein G-D-S-L family
A0O21_RS10060	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A0O21_RS10065	COG0534	Mate efflux family protein
A0O21_RS10070	COG0051	transcription antitermination factor activity, RNA binding
A0O21_RS10075	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A0O21_RS10080	COG0088	Forms part of the polypeptide exit tunnel
A0O21_RS10115	COG0255	Belongs to the universal ribosomal protein uL29 family
A0O21_RS10135	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A0O21_RS10140	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A0O21_RS10160	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A0O21_RS10175	COG0201	protein transport
A0O21_RS10180	COG0563	adenylate kinase activity
A0O21_RS10190	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A0O21_RS10200	COG0202	RNA polymerase activity
A0O21_RS10295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A0O21_RS10305	COG1121	(ABC) transporter
A0O21_RS10310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A0O21_RS10320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A0O21_RS10325	COG0656	L-ascorbic acid biosynthetic process
A0O21_RS10360	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A0O21_RS10365	COG1459	type II secretion system
A0O21_RS10390	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A0O21_RS10395	COG1363	Peptidase, m42
A0O21_RS10405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A0O21_RS10415	COG2190	(PTS) system
A0O21_RS10415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A0O21_RS10415	COG1263	PTS System
A0O21_RS10420	COG1349	DNA-binding transcription factor activity
A0O21_RS10435	COG4585	Histidine kinase
A0O21_RS10440	COG2197	response regulator
A0O21_RS10450	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0O21_RS10460	COG3715	PTS system
A0O21_RS10465	COG3716	PTS system mannose fructose sorbose family IID component
A0O21_RS10475	COG1737	Transcriptional regulator
A0O21_RS10480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A0O21_RS10480	COG1263	PTS System
A0O21_RS10505	COG4120	Belongs to the binding-protein-dependent transport system permease family
A0O21_RS10520	COG0459	protein refolding