locus-tag	class	description
HMPREF0833_RS00010	COG1739	Uncharacterized protein family UPF0029
HMPREF0833_RS00015	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HMPREF0833_RS00110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HMPREF0833_RS00145	COG0519	Catalyzes the synthesis of GMP from XMP
HMPREF0833_RS00165	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HMPREF0833_RS00170	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HMPREF0833_RS00175	COG1534	Rna-binding protein
HMPREF0833_RS00180	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HMPREF0833_RS00185	COG1713	HD superfamily hydrolase involved in NAD metabolism
HMPREF0833_RS00190	COG1335	isochorismatase
HMPREF0833_RS00195	COG0799	negative regulation of ribosome biogenesis
HMPREF0833_RS00200	COG2226	methyltransferase
HMPREF0833_RS00220	COG0217	transcriptional regulatory protein
HMPREF0833_RS00235	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMPREF0833_RS00240	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HMPREF0833_RS00250	COG0742	ribosomal rna small subunit methyltransferase
HMPREF0833_RS00255	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HMPREF0833_RS00260	COG3480	Lon protease (S16) C-terminal proteolytic domain
HMPREF0833_RS00265	COG0785	Cytochrome C biogenesis protein
HMPREF0833_RS00280	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMPREF0833_RS00280	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMPREF0833_RS00285	COG2207	Transcriptional regulator
HMPREF0833_RS00285	COG4753	response regulator
HMPREF0833_RS00290	COG2972	Histidine kinase
HMPREF0833_RS00295	COG4470	Protein conserved in bacteria
HMPREF0833_RS00300	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HMPREF0833_RS00310	COG0133	tryptophan synthase activity
HMPREF0833_RS00325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HMPREF0833_RS00330	COG1187	pseudouridine synthase activity
HMPREF0833_RS00335	COG1217	gtp-binding protein TYPA
HMPREF0833_RS00355	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HMPREF0833_RS00365	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HMPREF0833_RS00370	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HMPREF0833_RS00375	COG1799	cell septum assembly
HMPREF0833_RS00390	COG3599	regulation of cell shape
HMPREF0833_RS00395	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HMPREF0833_RS00405	COG0494	nUDIX hydrolase
HMPREF0833_RS00410	COG2378	regulation of single-species biofilm formation
HMPREF0833_RS00420	COG0542	response to heat
HMPREF0833_RS00425	COG4703	Protein of unknown function (DUF1797)
HMPREF0833_RS00430	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HMPREF0833_RS00440	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HMPREF0833_RS00445	COG1621	beta-fructofuranosidase activity
HMPREF0833_RS00455	COG0281	malic enzyme
HMPREF0833_RS00460	COG0583	DNA-binding transcription factor activity
HMPREF0833_RS00465	COG1570	exodeoxyribonuclease VII activity
HMPREF0833_RS00470	COG1722	exodeoxyribonuclease VII activity
HMPREF0833_RS00480	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HMPREF0833_RS00485	COG1438	arginine binding
HMPREF0833_RS00490	COG0497	DNA recombination
HMPREF0833_RS00495	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HMPREF0833_RS00500	COG1307	EDD domain protein, DegV family
HMPREF0833_RS00520	COG0588	phosphoglycerate mutase activity
HMPREF0833_RS00525	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPREF0833_RS00525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPREF0833_RS00530	COG3655	Transcriptional regulator
HMPREF0833_RS00550	COG0803	Belongs to the bacterial solute-binding protein 9 family
HMPREF0833_RS00565	COG0745	RESPONSE REGULATOR receiver
HMPREF0833_RS00570	COG2205	protein histidine kinase activity
HMPREF0833_RS00575	COG1136	(ABC) transporter
HMPREF0833_RS00580	COG0577	efflux transmembrane transporter activity
HMPREF0833_RS00605	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HMPREF0833_RS00615	COG0732	type I restriction modification DNA specificity domain
HMPREF0833_RS00665	COG0477	Major facilitator Superfamily
HMPREF0833_RS00670	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HMPREF0833_RS00690	COG1136	(ABC) transporter
HMPREF0833_RS00695	COG0577	efflux transmembrane transporter activity
HMPREF0833_RS00700	COG4166	transmembrane transport
HMPREF0833_RS00705	COG1695	Transcriptional regulator
HMPREF0833_RS00720	COG0531	amino acid
HMPREF0833_RS00730	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF0833_RS00770	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HMPREF0833_RS00775	COG0494	nUDIX hydrolase
HMPREF0833_RS00785	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HMPREF0833_RS00790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HMPREF0833_RS00795	COG4166	transmembrane transport
HMPREF0833_RS00805	COG0708	Exodeoxyribonuclease III
HMPREF0833_RS00815	COG2323	membrane
HMPREF0833_RS00820	COG0768	penicillin binding
HMPREF0833_RS00825	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HMPREF0833_RS00835	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HMPREF0833_RS00840	COG1051	belongs to the nudix hydrolase family
HMPREF0833_RS00860	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HMPREF0833_RS00875	COG0513	Belongs to the DEAD box helicase family
HMPREF0833_RS00885	COG2827	Endonuclease containing a URI domain
HMPREF0833_RS00890	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HMPREF0833_RS00900	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HMPREF0833_RS00905	COG0204	Acyl-transferase
HMPREF0833_RS00910	COG1555	photosystem II stabilization
HMPREF0833_RS00910	COG1596	polysaccharide export
HMPREF0833_RS00915	COG0658	competence protein
HMPREF0833_RS00915	COG2333	competence protein COMEC
HMPREF0833_RS00930	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HMPREF0833_RS00935	COG0433	COG0433 Predicted ATPase
HMPREF0833_RS00950	COG2235	arginine
HMPREF0833_RS00955	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HMPREF0833_RS00960	COG0549	Belongs to the carbamate kinase family
HMPREF0833_RS00965	COG1288	antiporter activity
HMPREF0833_RS00970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HMPREF0833_RS00975	COG1438	arginine binding
HMPREF0833_RS00980	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HMPREF0833_RS00990	COG1686	Belongs to the peptidase S11 family
HMPREF0833_RS01015	COG4122	O-methyltransferase activity
HMPREF0833_RS01020	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HMPREF0833_RS01030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HMPREF0833_RS01035	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMPREF0833_RS01040	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMPREF0833_RS01045	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HMPREF0833_RS01050	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF0833_RS01060	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HMPREF0833_RS01070	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HMPREF0833_RS01075	COG0297	glycogen (starch) synthase activity
HMPREF0833_RS01080	COG3064	Membrane
HMPREF0833_RS01090	COG0356	it plays a direct role in the translocation of protons across the membrane
HMPREF0833_RS01095	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HMPREF0833_RS01100	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HMPREF0833_RS01105	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HMPREF0833_RS01110	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HMPREF0833_RS01120	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HMPREF0833_RS01130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HMPREF0833_RS01150	COG0488	(ABC) transporter
HMPREF0833_RS01165	COG2814	Major facilitator Superfamily
HMPREF0833_RS01185	COG3442	glutamine amidotransferase
HMPREF0833_RS01190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HMPREF0833_RS01195	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HMPREF0833_RS01205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HMPREF0833_RS01210	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HMPREF0833_RS01220	COG0251	oxidation-reduction process
HMPREF0833_RS01225	COG1660	Displays ATPase and GTPase activities
HMPREF0833_RS01230	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HMPREF0833_RS01235	COG1481	regulation of sporulation
HMPREF0833_RS01240	COG0492	ferredoxin-NADP+ reductase activity
HMPREF0833_RS01245	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HMPREF0833_RS01250	COG1970	mechanosensitive ion channel activity
HMPREF0833_RS01255	COG0358	DNA primase activity
HMPREF0833_RS01260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMPREF0833_RS01265	COG2151	metal-sulfur cluster biosynthetic enzyme
HMPREF0833_RS01270	COG1131	(ABC) transporter
HMPREF0833_RS01290	COG0205	6-phosphofructokinase activity
HMPREF0833_RS01295	COG0469	pyruvate kinase activity
HMPREF0833_RS01305	COG0765	amino acid transport
HMPREF0833_RS01310	COG1126	abc transporter atp-binding protein
HMPREF0833_RS01320	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HMPREF0833_RS01325	COG0210	DNA helicase
HMPREF0833_RS01345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMPREF0833_RS01350	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HMPREF0833_RS01355	COG0196	riboflavin kinase activity
HMPREF0833_RS01360	COG1393	Belongs to the ArsC family
HMPREF0833_RS01370	COG0483	inositol monophosphate 1-phosphatase activity
HMPREF0833_RS01375	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HMPREF0833_RS01375	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HMPREF0833_RS01380	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HMPREF0833_RS01385	COG0573	inorganic phosphate transmembrane transporter activity
HMPREF0833_RS01390	COG0581	inorganic phosphate transmembrane transporter activity
HMPREF0833_RS01395	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HMPREF0833_RS01400	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HMPREF0833_RS01405	COG0704	Plays a role in the regulation of phosphate uptake
HMPREF0833_RS01420	COG3279	Response regulator of the LytR AlgR family
HMPREF0833_RS01425	COG1131	(ABC) transporter
HMPREF0833_RS01435	COG1268	BioY protein
HMPREF0833_RS01445	COG0745	RESPONSE REGULATOR receiver
HMPREF0833_RS01450	COG5002	protein histidine kinase activity
HMPREF0833_RS01460	COG0726	polysaccharide deacetylase
HMPREF0833_RS01470	COG0673	inositol 2-dehydrogenase activity
HMPREF0833_RS01475	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HMPREF0833_RS01505	COG0463	Glycosyl transferase, family 2
HMPREF0833_RS01515	COG1091	dTDP-4-dehydrorhamnose reductase activity
HMPREF0833_RS01525	COG1215	transferase activity, transferring glycosyl groups
HMPREF0833_RS01550	COG1368	sulfuric ester hydrolase activity
HMPREF0833_RS01565	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HMPREF0833_RS01575	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HMPREF0833_RS01580	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HMPREF0833_RS01585	COG2131	deaminase
HMPREF0833_RS01595	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HMPREF0833_RS01600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HMPREF0833_RS01605	COG4109	DRTGG domain
HMPREF0833_RS01610	COG0024	Methionine aminopeptidase
HMPREF0833_RS01620	COG1846	Transcriptional regulator
HMPREF0833_RS01635	COG4708	membrane
HMPREF0833_RS01640	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HMPREF0833_RS01645	COG1597	lipid kinase activity
HMPREF0833_RS01650	COG1523	belongs to the glycosyl hydrolase 13 family
HMPREF0833_RS01655	COG1368	sulfuric ester hydrolase activity
HMPREF0833_RS01660	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HMPREF0833_RS01665	COG0710	3-dehydroquinate dehydratase activity
HMPREF0833_RS01670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HMPREF0833_RS01675	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HMPREF0833_RS01680	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HMPREF0833_RS01690	COG3679	Belongs to the UPF0342 family
HMPREF0833_RS01695	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HMPREF0833_RS01700	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HMPREF0833_RS01705	COG0077	Prephenate dehydratase
HMPREF0833_RS01715	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HMPREF0833_RS01720	COG1737	Transcriptional regulator
HMPREF0833_RS01730	COG2723	6-phospho-beta-galactosidase activity
HMPREF0833_RS01740	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HMPREF0833_RS01745	COG1447	Phosphotransferase system cellobiose-specific component IIA
HMPREF0833_RS01760	COG0135	phosphoribosylanthranilate isomerase activity
HMPREF0833_RS01785	COG1132	(ABC) transporter
HMPREF0833_RS01805	COG1131	(ABC) transporter
HMPREF0833_RS01840	COG3620	sequence-specific DNA binding
HMPREF0833_RS01910	COG3196	Protein conserved in bacteria
HMPREF0833_RS01930	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HMPREF0833_RS01950	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HMPREF0833_RS01980	COG0716	FMN binding
HMPREF0833_RS01990	COG0038	chloride channel
HMPREF0833_RS02030	COG1518	maintenance of DNA repeat elements
HMPREF0833_RS02035	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HMPREF0833_RS02050	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HMPREF0833_RS02055	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HMPREF0833_RS02070	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HMPREF0833_RS02075	COG0038	chloride channel
HMPREF0833_RS02085	COG0813	purine-nucleoside phosphorylase activity
HMPREF0833_RS02100	COG0583	DNA-binding transcription factor activity
HMPREF0833_RS02110	COG0543	2 iron, 2 sulfur cluster binding
HMPREF0833_RS02115	COG0167	dihydroorotate dehydrogenase activity
HMPREF0833_RS02120	COG0284	orotidine-5'-phosphate decarboxylase activity
HMPREF0833_RS02140	COG1051	belongs to the nudix hydrolase family
HMPREF0833_RS02145	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HMPREF0833_RS02150	COG2755	lipolytic protein G-D-S-L family
HMPREF0833_RS02180	COG0066	3-isopropylmalate dehydratase activity
HMPREF0833_RS02195	COG0187	DNA topoisomerase II activity
HMPREF0833_RS02210	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMPREF0833_RS02215	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HMPREF0833_RS02235	COG0539	negative regulation of cytoplasmic translation
HMPREF0833_RS02250	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMPREF0833_RS02255	COG3764	Sortase (surface protein transpeptidase)
HMPREF0833_RS02265	COG2003	Belongs to the UPF0758 family
HMPREF0833_RS02285	COG1104	cysteine desulfurase activity
HMPREF0833_RS02290	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HMPREF0833_RS02295	COG4116	CYTH
HMPREF0833_RS02300	COG2357	RelA SpoT domain protein
HMPREF0833_RS02310	COG0564	pseudouridine synthase activity
HMPREF0833_RS02315	COG0280	phosphate acetyltransferase
HMPREF0833_RS02320	COG1194	a g-specific adenine glycosylase
HMPREF0833_RS02330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HMPREF0833_RS02335	COG4684	Psort location CytoplasmicMembrane, score
HMPREF0833_RS02340	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HMPREF0833_RS02355	COG0534	Mate efflux family protein
HMPREF0833_RS02370	COG1114	Component of the transport system for branched-chain amino acids
HMPREF0833_RS02375	COG0785	Cytochrome C biogenesis protein
HMPREF0833_RS02380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HMPREF0833_RS02385	COG3976	FMN-binding domain protein
HMPREF0833_RS02385	COG1053	succinate dehydrogenase
HMPREF0833_RS02385	COG0431	NADPH-dependent FMN reductase
HMPREF0833_RS02415	COG2837	iron assimilation
HMPREF0833_RS02420	COG0672	)-iron permease
HMPREF0833_RS02425	COG0805	protein transport
HMPREF0833_RS02430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HMPREF0833_RS02460	COG2233	PERMEase
HMPREF0833_RS02465	COG0534	Mate efflux family protein
HMPREF0833_RS02470	COG0129	dihydroxy-acid dehydratase activity
HMPREF0833_RS02475	COG1942	4-Oxalocrotonate Tautomerase
HMPREF0833_RS02480	COG1435	thymidine kinase activity
HMPREF0833_RS02485	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HMPREF0833_RS02490	COG2890	protein-(glutamine-N5) methyltransferase activity
HMPREF0833_RS02510	COG0741	lytic transglycosylase activity
HMPREF0833_RS02525	COG2188	Transcriptional regulator
HMPREF0833_RS02535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HMPREF0833_RS02550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HMPREF0833_RS02555	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HMPREF0833_RS02560	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HMPREF0833_RS02570	COG3458	cephalosporin-C deacetylase activity
HMPREF0833_RS02580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HMPREF0833_RS02590	COG0095	Lipoate-protein ligase
HMPREF0833_RS02595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMPREF0833_RS02600	COG0508	dehydrogenase complex catalyzes the overall conversion of
HMPREF0833_RS02605	COG0022	dehydrogenase e1 component
HMPREF0833_RS02610	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HMPREF0833_RS02645	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HMPREF0833_RS02650	COG0758	DNA mediated transformation
HMPREF0833_RS02665	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HMPREF0833_RS02680	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HMPREF0833_RS02700	COG1132	(ABC) transporter
HMPREF0833_RS02725	COG4974	Belongs to the 'phage' integrase family
HMPREF0833_RS02735	COG1372	Participates in initiation and elongation during chromosome replication
HMPREF0833_RS02735	COG0305	Participates in initiation and elongation during chromosome replication
HMPREF0833_RS02770	COG2957	Belongs to the agmatine deiminase family
HMPREF0833_RS02775	COG0531	amino acid
HMPREF0833_RS02780	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HMPREF0833_RS02785	COG2197	response regulator
HMPREF0833_RS02790	COG0515	serine threonine protein kinase
HMPREF0833_RS02805	COG1002	Type II restriction enzyme, methylase subunits
HMPREF0833_RS02850	COG0235	Class ii aldolase
HMPREF0833_RS02870	COG3408	Glycogen debranching enzyme
HMPREF0833_RS02880	COG2211	Major facilitator Superfamily
HMPREF0833_RS02890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HMPREF0833_RS02895	COG1454	alcohol dehydrogenase
HMPREF0833_RS02900	COG0222	ribosome binding
HMPREF0833_RS02905	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HMPREF0833_RS02915	COG1705	Flagellar rod assembly protein muramidase FlgJ
HMPREF0833_RS02915	COG1388	LysM domain
HMPREF0833_RS02935	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HMPREF0833_RS02945	COG1940	carbohydrate kinase activity
HMPREF0833_RS02955	COG0488	(ABC) transporter
HMPREF0833_RS02960	COG0617	tRNA 3'-terminal CCA addition
HMPREF0833_RS02965	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HMPREF0833_RS02970	COG1307	EDD domain protein, DegV family
HMPREF0833_RS02980	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF0833_RS02980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF0833_RS02980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF0833_RS02985	COG1105	Belongs to the carbohydrate kinase PfkB family
HMPREF0833_RS02990	COG1349	DNA-binding transcription factor activity
HMPREF0833_RS03020	COG1837	Belongs to the UPF0109 family
HMPREF0833_RS03030	COG1011	Hydrolase
HMPREF0833_RS03060	COG0561	phosphatase activity
HMPREF0833_RS03065	COG2195	Cleaves the N-terminal amino acid of tripeptides
HMPREF0833_RS03070	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HMPREF0833_RS03075	COG0505	Belongs to the CarA family
HMPREF0833_RS03080	COG0540	Belongs to the ATCase OTCase family
HMPREF0833_RS03085	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HMPREF0833_RS03095	COG2824	Alkylphosphonate utilization operon protein PhnA
HMPREF0833_RS03115	COG1131	(ABC) transporter
HMPREF0833_RS03120	COG1051	belongs to the nudix hydrolase family
HMPREF0833_RS03160	COG1131	(ABC) transporter
HMPREF0833_RS03180	COG0765	amino acid transport
HMPREF0833_RS03185	COG1126	abc transporter atp-binding protein
HMPREF0833_RS03190	COG1132	(ABC) transporter
HMPREF0833_RS03195	COG1132	(ABC) transporter
HMPREF0833_RS03210	COG0017	Asparaginyl-tRNA synthetase
HMPREF0833_RS03215	COG0436	Aminotransferase
HMPREF0833_RS03225	COG1846	Transcriptional regulator
HMPREF0833_RS03240	COG1272	protein, Hemolysin III
HMPREF0833_RS03245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HMPREF0833_RS03255	COG1132	(ABC) transporter
HMPREF0833_RS03260	COG1132	(ABC) transporter
HMPREF0833_RS03265	COG2315	Protein conserved in bacteria
HMPREF0833_RS03270	COG3142	Participates in the control of copper homeostasis
HMPREF0833_RS03280	COG1079	Belongs to the binding-protein-dependent transport system permease family
HMPREF0833_RS03285	COG4603	Belongs to the binding-protein-dependent transport system permease family
HMPREF0833_RS03290	COG3845	ABC transporter
HMPREF0833_RS03295	COG1744	ABC transporter substrate-binding protein PnrA-like
HMPREF0833_RS03305	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HMPREF0833_RS03315	COG2813	Specifically methylates the guanine in position
HMPREF0833_RS03320	COG1072	(Pantothenic acid kinase))
HMPREF0833_RS03330	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HMPREF0833_RS03360	COG1573	uracil-dna glycosylase
HMPREF0833_RS03395	COG0647	UMP catabolic process
HMPREF0833_RS03410	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HMPREF0833_RS03420	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HMPREF0833_RS03425	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HMPREF0833_RS03435	COG0564	pseudouridine synthase activity
HMPREF0833_RS03440	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HMPREF0833_RS03445	COG0583	DNA-binding transcription factor activity
HMPREF0833_RS03465	COG3711	transcriptional antiterminator
HMPREF0833_RS03480	COG0698	ribose 5-phosphate isomerase
HMPREF0833_RS03490	COG3775	system Galactitol-specific IIC component
HMPREF0833_RS03505	COG1349	DNA-binding transcription factor activity
HMPREF0833_RS03510	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HMPREF0833_RS03525	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HMPREF0833_RS03530	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HMPREF0833_RS03535	COG0517	IMP dehydrogenase activity
HMPREF0833_RS03540	COG0574	Belongs to the PEP-utilizing enzyme family
HMPREF0833_RS03540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HMPREF0833_RS03550	COG1104	cysteine desulfurase activity
HMPREF0833_RS03570	COG1177	transmembrane transport
HMPREF0833_RS03575	COG1177	transmembrane transport
HMPREF0833_RS03580	COG3842	ATPase activity
HMPREF0833_RS03600	COG0460	homoserine dehydrogenase
HMPREF0833_RS03610	COG1418	mRNA catabolic process
HMPREF0833_RS03630	COG1131	(ABC) transporter
HMPREF0833_RS03635	COG4187	Peptidase family M20/M25/M40
HMPREF0833_RS03650	COG3118	belongs to the thioredoxin family
HMPREF0833_RS03660	COG4166	transmembrane transport
HMPREF0833_RS03665	COG1363	Peptidase, m42
HMPREF0833_RS03690	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HMPREF0833_RS03700	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HMPREF0833_RS03710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HMPREF0833_RS03720	COG1472	Belongs to the glycosyl hydrolase 3 family
HMPREF0833_RS03730	COG0366	Alpha amylase catalytic
HMPREF0833_RS03735	COG0395	ABC-type sugar transport system, permease component
HMPREF0833_RS03740	COG1175	transmembrane transport
HMPREF0833_RS03745	COG1653	transport
HMPREF0833_RS03750	COG3345	alpha-galactosidase
HMPREF0833_RS03755	COG2207	Transcriptional regulator
HMPREF0833_RS03760	COG1609	Transcriptional regulator
HMPREF0833_RS03775	COG0577	efflux transmembrane transporter activity
HMPREF0833_RS03785	COG5002	protein histidine kinase activity
HMPREF0833_RS03790	COG0745	RESPONSE REGULATOR receiver
HMPREF0833_RS03800	COG1136	(ABC) transporter
HMPREF0833_RS03825	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HMPREF0833_RS03840	COG0572	uridine kinase
HMPREF0833_RS03855	COG2223	nitrite transmembrane transporter activity
HMPREF0833_RS03860	COG2207	Transcriptional regulator
HMPREF0833_RS03870	COG1088	dTDP-glucose 4,6-dehydratase activity
HMPREF0833_RS03880	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HMPREF0833_RS03890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HMPREF0833_RS03895	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HMPREF0833_RS03900	COG2384	SAM-dependent methyltransferase
HMPREF0833_RS03905	COG0625	glutathione transferase activity
HMPREF0833_RS03910	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HMPREF0833_RS03930	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HMPREF0833_RS03940	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HMPREF0833_RS03940	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HMPREF0833_RS03950	COG2226	methyltransferase
HMPREF0833_RS03955	COG0300	oxidoreductase activity
HMPREF0833_RS03970	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HMPREF0833_RS03990	COG1074	ATP-dependent DNA helicase activity
HMPREF0833_RS03995	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HMPREF0833_RS04000	COG0386	Belongs to the glutathione peroxidase family
HMPREF0833_RS04015	COG1132	(ABC) transporter
HMPREF0833_RS04020	COG1132	(ABC) transporter
HMPREF0833_RS04045	COG4989	oxidoreductase activity
HMPREF0833_RS04050	COG1668	transmembrane transport
HMPREF0833_RS04055	COG4152	abc transporter atp-binding protein
HMPREF0833_RS04065	COG1476	TRANSCRIPTIONal
HMPREF0833_RS04090	COG0072	phenylalanine-tRNA ligase activity
HMPREF0833_RS04090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPREF0833_RS04115	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HMPREF0833_RS04120	COG3527	Alpha-acetolactate decarboxylase
HMPREF0833_RS04125	COG0457	Tetratricopeptide repeat
HMPREF0833_RS04130	COG0628	permease
HMPREF0833_RS04135	COG2706	6-phosphogluconolactonase activity
HMPREF0833_RS04160	COG0560	Phosphoserine phosphatase
HMPREF0833_RS04165	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HMPREF0833_RS04170	COG0187	DNA topoisomerase II activity
HMPREF0833_RS04175	COG0546	phosphoglycolate phosphatase activity
HMPREF0833_RS04185	COG0772	Belongs to the SEDS family
HMPREF0833_RS04190	COG2855	membrane
HMPREF0833_RS04195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HMPREF0833_RS04195	COG1199	ATP-dependent helicase activity
HMPREF0833_RS04205	COG2177	Part of the ABC transporter FtsEX involved in
HMPREF0833_RS04210	COG2884	Cell division ATP-binding protein ftsE
HMPREF0833_RS04215	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HMPREF0833_RS04235	COG1078	dGTPase activity
HMPREF0833_RS04245	COG2348	transferase activity, transferring amino-acyl groups
HMPREF0833_RS04260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HMPREF0833_RS04265	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HMPREF0833_RS04270	COG0772	Belongs to the SEDS family
HMPREF0833_RS04280	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HMPREF0833_RS04295	COG0577	efflux transmembrane transporter activity
HMPREF0833_RS04300	COG1136	(ABC) transporter
HMPREF0833_RS04305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HMPREF0833_RS04310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMPREF0833_RS04315	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HMPREF0833_RS04320	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HMPREF0833_RS04325	COG4443	Transcriptional Coactivator p15 (PC4)
HMPREF0833_RS04345	COG0477	Major facilitator Superfamily
HMPREF0833_RS04350	COG0826	peptidase U32
HMPREF0833_RS04375	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HMPREF0833_RS04380	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HMPREF0833_RS04405	COG2183	response to ionizing radiation
HMPREF0833_RS04410	COG0701	Predicted permease
HMPREF0833_RS04415	COG3689	TIGRFAM TIGR03943 family protein
HMPREF0833_RS04420	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HMPREF0833_RS04425	COG0552	protein localization to endoplasmic reticulum
HMPREF0833_RS04430	COG0561	phosphatase activity
HMPREF0833_RS04435	COG0561	phosphatase activity
HMPREF0833_RS04440	COG1196	nuclear chromosome segregation
HMPREF0833_RS04445	COG0571	ribonuclease III activity
HMPREF0833_RS04450	COG2832	Protein of unknown function (DUF454)
HMPREF0833_RS04455	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HMPREF0833_RS04460	COG5002	protein histidine kinase activity
HMPREF0833_RS04465	COG0745	RESPONSE REGULATOR receiver
HMPREF0833_RS04475	COG0438	transferase activity, transferring glycosyl groups
HMPREF0833_RS04485	COG1609	Transcriptional regulator
HMPREF0833_RS04490	COG0006	proline dipeptidase activity
HMPREF0833_RS04515	COG1136	(ABC) transporter
HMPREF0833_RS04515	COG0577	efflux transmembrane transporter activity
HMPREF0833_RS04520	COG1914	H( )-stimulated, divalent metal cation uptake system
HMPREF0833_RS04530	COG0500	methyltransferase
HMPREF0833_RS04530	COG3615	Tellurite resistance protein tehB
HMPREF0833_RS04540	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HMPREF0833_RS04545	COG0557	exoribonuclease II activity
HMPREF0833_RS04555	COG2814	Major facilitator Superfamily
HMPREF0833_RS04560	COG0237	dephospho-CoA kinase activity
HMPREF0833_RS04565	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HMPREF0833_RS04575	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HMPREF0833_RS04585	COG1132	(ABC) transporter
HMPREF0833_RS04590	COG1132	(ABC) transporter
HMPREF0833_RS04605	COG0686	Belongs to the AlaDH PNT family
HMPREF0833_RS04610	COG1702	phosphate starvation-inducible protein PhoH
HMPREF0833_RS04630	COG0528	UMP kinase activity
HMPREF0833_RS04645	COG0081	regulation of translation
HMPREF0833_RS04650	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HMPREF0833_RS04660	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HMPREF0833_RS04665	COG0346	lactoylglutathione lyase activity
HMPREF0833_RS04670	COG0697	spore germination
HMPREF0833_RS04670	COG1674	ftsk spoiiie
HMPREF0833_RS04685	COG0697	spore germination
HMPREF0833_RS04695	COG0488	(ABC) transporter
HMPREF0833_RS04700	COG1393	Belongs to the ArsC family
HMPREF0833_RS04705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HMPREF0833_RS04720	COG4467	Involved in initiation control of chromosome replication
HMPREF0833_RS04725	COG0470	DNA polymerase III
HMPREF0833_RS04730	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HMPREF0833_RS04735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HMPREF0833_RS04740	COG0517	IMP dehydrogenase activity
HMPREF0833_RS04740	COG0617	tRNA 3'-terminal CCA addition
HMPREF0833_RS04740	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HMPREF0833_RS04780	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HMPREF0833_RS04785	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HMPREF0833_RS04790	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HMPREF0833_RS04795	COG0626	cystathionine gamma-synthase activity
HMPREF0833_RS04800	COG2244	polysaccharide biosynthetic process
HMPREF0833_RS04805	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HMPREF0833_RS04825	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HMPREF0833_RS04835	COG0366	Alpha amylase catalytic
HMPREF0833_RS04840	COG1263	PTS System
HMPREF0833_RS04840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF0833_RS04845	COG2188	Transcriptional regulator
HMPREF0833_RS04855	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HMPREF0833_RS04860	COG4120	Belongs to the binding-protein-dependent transport system permease family
HMPREF0833_RS04870	COG1253	flavin adenine dinucleotide binding
HMPREF0833_RS04875	COG3711	transcriptional antiterminator
HMPREF0833_RS04880	COG0628	permease
HMPREF0833_RS04975	COG1119	ATPase activity
HMPREF0833_RS05010	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HMPREF0833_RS05015	COG1242	4 iron, 4 sulfur cluster binding
HMPREF0833_RS05020	COG0671	phosphoesterase, PA-phosphatase related
HMPREF0833_RS05025	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HMPREF0833_RS05035	COG0569	domain protein
HMPREF0833_RS05050	COG1187	pseudouridine synthase activity
HMPREF0833_RS05055	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HMPREF0833_RS05060	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HMPREF0833_RS05065	COG4974	Belongs to the 'phage' integrase family
HMPREF0833_RS05070	COG0517	IMP dehydrogenase activity
HMPREF0833_RS05085	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HMPREF0833_RS05110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HMPREF0833_RS05115	COG1254	Belongs to the acylphosphatase family
HMPREF0833_RS05125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HMPREF0833_RS05130	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HMPREF0833_RS05155	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HMPREF0833_RS05175	COG0778	Nitroreductase
HMPREF0833_RS05180	COG1484	DNA-dependent DNA replication
HMPREF0833_RS05190	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HMPREF0833_RS05200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF0833_RS05200	COG2190	(PTS) system
HMPREF0833_RS05200	COG1263	PTS System
HMPREF0833_RS05205	COG0745	RESPONSE REGULATOR receiver
HMPREF0833_RS05210	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HMPREF0833_RS05215	COG2268	Band 7 protein
HMPREF0833_RS05240	COG0501	Belongs to the peptidase M48B family
HMPREF0833_RS05245	COG1704	LemA family
HMPREF0833_RS05250	COG0357	Ribosomal RNA small subunit methyltransferase G
HMPREF0833_RS05255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HMPREF0833_RS05260	COG4221	oxidoreductase activity
HMPREF0833_RS05270	COG1122	ATPase activity
HMPREF0833_RS05340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF0833_RS05345	COG1473	amidohydrolase
HMPREF0833_RS05360	COG1063	alcohol dehydrogenase
HMPREF0833_RS05370	COG1309	transcriptional regulator
HMPREF0833_RS05390	COG1335	isochorismatase
HMPREF0833_RS05395	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HMPREF0833_RS05400	COG0436	Aminotransferase
HMPREF0833_RS05405	COG0589	response to stress
HMPREF0833_RS05410	COG0561	phosphatase activity
HMPREF0833_RS05415	COG0252	asparaginase activity
HMPREF0833_RS05420	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HMPREF0833_RS05425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HMPREF0833_RS05430	COG0736	holo-[acyl-carrier-protein] synthase activity
HMPREF0833_RS05435	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HMPREF0833_RS05440	COG0653	protein targeting
HMPREF0833_RS05445	COG0531	amino acid
HMPREF0833_RS05450	COG0789	Transcriptional regulator
HMPREF0833_RS05455	COG1482	cell wall glycoprotein biosynthetic process
HMPREF0833_RS05460	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HMPREF0833_RS05475	COG1132	(ABC) transporter
HMPREF0833_RS05490	COG0242	peptide deformylase activity
HMPREF0833_RS05495	COG1940	carbohydrate kinase activity
HMPREF0833_RS05500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF0833_RS05500	COG2190	(PTS) system
HMPREF0833_RS05500	COG1263	PTS System
HMPREF0833_RS05505	COG1621	beta-fructofuranosidase activity
HMPREF0833_RS05510	COG1609	Transcriptional regulator
HMPREF0833_RS05530	COG0006	proline dipeptidase activity
HMPREF0833_RS05535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HMPREF0833_RS05580	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HMPREF0833_RS05585	COG0629	single-stranded DNA binding
HMPREF0833_RS05615	COG1404	Belongs to the peptidase S8 family
HMPREF0833_RS05615	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HMPREF0833_RS05625	COG0737	Belongs to the 5'-nucleotidase family
HMPREF0833_RS05630	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HMPREF0833_RS05635	COG1228	amidohydrolase
HMPREF0833_RS05640	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HMPREF0833_RS05650	COG3404	Formiminotransferase-cyclodeaminase
HMPREF0833_RS05665	COG0531	amino acid
HMPREF0833_RS05670	COG2986	histidine ammonia-lyase
HMPREF0833_RS05695	COG0366	Alpha amylase catalytic
HMPREF0833_RS05710	COG0569	domain protein
HMPREF0833_RS05715	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HMPREF0833_RS05725	COG0110	maltose O-acetyltransferase activity
HMPREF0833_RS05730	COG1349	DNA-binding transcription factor activity
HMPREF0833_RS05735	COG0561	phosphatase activity
HMPREF0833_RS05750	COG0583	DNA-binding transcription factor activity
HMPREF0833_RS05755	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HMPREF0833_RS05765	COG1230	cation diffusion facilitator family transporter
HMPREF0833_RS05795	COG1122	ATPase activity
HMPREF0833_RS05805	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HMPREF0833_RS05820	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HMPREF0833_RS05840	COG2205	protein histidine kinase activity
HMPREF0833_RS05845	COG0745	RESPONSE REGULATOR receiver
HMPREF0833_RS05850	COG2723	6-phospho-beta-galactosidase activity
HMPREF0833_RS05860	COG0028	Belongs to the TPP enzyme family
HMPREF0833_RS05885	COG0561	phosphatase activity
HMPREF0833_RS05895	COG1811	Na channel or pump
HMPREF0833_RS05900	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HMPREF0833_RS05910	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMPREF0833_RS05910	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMPREF0833_RS05925	COG0167	dihydroorotate dehydrogenase activity
HMPREF0833_RS05930	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HMPREF0833_RS05940	COG0668	transmembrane transport
HMPREF0833_RS05945	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HMPREF0833_RS05950	COG1115	amino acid carrier protein
HMPREF0833_RS05960	COG1193	negative regulation of DNA recombination
HMPREF0833_RS05980	COG0681	Belongs to the peptidase S26 family
HMPREF0833_RS05985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HMPREF0833_RS05990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMPREF0833_RS05995	COG1882	Formate acetyltransferase
HMPREF0833_RS06010	COG3425	synthase
HMPREF0833_RS06035	COG1304	FMN binding
HMPREF0833_RS06050	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HMPREF0833_RS06055	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HMPREF0833_RS06090	COG1346	cytolysis
HMPREF0833_RS06095	COG1380	Effector of murein hydrolase LrgA
HMPREF0833_RS06100	COG2081	HI0933 family
HMPREF0833_RS06150	COG0456	acetyltransferase
HMPREF0833_RS06155	COG1214	PFAM Peptidase M22, glycoprotease
HMPREF0833_RS06160	COG5503	Protein of unknown function (DUF1447)
HMPREF0833_RS06170	COG0174	glutamine synthetase
HMPREF0833_RS06175	COG0789	Transcriptional regulator
HMPREF0833_RS06185	COG0126	phosphoglycerate kinase activity
HMPREF0833_RS06190	COG0366	Alpha amylase catalytic
HMPREF0833_RS06200	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HMPREF0833_RS06220	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HMPREF0833_RS06225	COG3481	metal-dependent phosphohydrolase, HD sub domain
HMPREF0833_RS06240	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HMPREF0833_RS06245	COG1162	GTPase activity
HMPREF0833_RS06275	COG0084	hydrolase, TatD family'
HMPREF0833_RS06295	COG0706	membrane insertase activity
HMPREF0833_RS06300	COG0594	ribonuclease P activity
HMPREF0833_RS06345	COG0653	protein targeting
HMPREF0833_RS06370	COG1442	glycosyl transferase family 8
HMPREF0833_RS06375	COG1442	glycosyl transferase family 8
HMPREF0833_RS06380	COG1442	glycosyl transferase family 8
HMPREF0833_RS06380	COG1216	Glycosyl transferase, family 2
HMPREF0833_RS06385	COG0438	transferase activity, transferring glycosyl groups
HMPREF0833_RS06400	COG1442	glycosyl transferase family 8
HMPREF0833_RS06405	COG1442	glycosyl transferase family 8
HMPREF0833_RS06415	COG1216	Glycosyl transferase, family 2
HMPREF0833_RS06415	COG1442	glycosyl transferase family 8
HMPREF0833_RS06445	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HMPREF0833_RS06465	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HMPREF0833_RS06475	COG0756	dUTP diphosphatase activity
HMPREF0833_RS06510	COG0366	Alpha amylase catalytic
HMPREF0833_RS06520	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HMPREF0833_RS06525	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HMPREF0833_RS06545	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HMPREF0833_RS06580	COG0166	Belongs to the GPI family
HMPREF0833_RS06590	COG1132	(ABC) transporter
HMPREF0833_RS06605	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HMPREF0833_RS06615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HMPREF0833_RS06630	COG3201	nicotinamide mononucleotide transporter
HMPREF0833_RS06635	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HMPREF0833_RS06655	COG0542	response to heat
HMPREF0833_RS06660	COG4463	regulation of RNA biosynthetic process
HMPREF0833_RS06670	COG3250	beta-galactosidase activity
HMPREF0833_RS06685	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HMPREF0833_RS06710	COG2321	neutral zinc metallopeptidase
HMPREF0833_RS06715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HMPREF0833_RS06720	COG0564	pseudouridine synthase activity
HMPREF0833_RS06745	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HMPREF0833_RS06770	COG3475	LICD family
HMPREF0833_RS06775	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HMPREF0833_RS06780	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HMPREF0833_RS06785	COG0489	protein tyrosine kinase activity
HMPREF0833_RS06790	COG3944	biosynthesis protein
HMPREF0833_RS06795	COG4464	protein tyrosine phosphatase activity
HMPREF0833_RS06800	COG1316	TRANSCRIPTIONal
HMPREF0833_RS06805	COG0602	queuosine metabolic process
HMPREF0833_RS06815	COG1328	CTP reductase activity
HMPREF0833_RS06825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HMPREF0833_RS06835	COG0285	dihydrofolate synthase activity
HMPREF0833_RS06840	COG3906	Belongs to the UPF0473 family
HMPREF0833_RS06845	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HMPREF0833_RS06850	COG4472	Bacterial protein of unknown function (DUF965)
HMPREF0833_RS06860	COG1393	Belongs to the ArsC family
HMPREF0833_RS06870	COG1058	Belongs to the CinA family
HMPREF0833_RS06870	COG1546	Belongs to the CinA family
HMPREF0833_RS06880	COG0519	Catalyzes the synthesis of GMP from XMP
HMPREF0833_RS06890	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HMPREF0833_RS06905	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HMPREF0833_RS06910	COG1438	arginine binding
HMPREF0833_RS06915	COG0018	arginyl-trna synthetase
HMPREF0833_RS06920	COG1780	Probably involved in ribonucleotide reductase function
HMPREF0833_RS06935	COG0058	SHG alpha-glucan phosphorylase activity
HMPREF0833_RS06940	COG1640	4-alpha-glucanotransferase
HMPREF0833_RS06945	COG2182	Extracellular solute-binding protein
HMPREF0833_RS06950	COG1175	transmembrane transport
HMPREF0833_RS06955	COG3833	ABC-type maltose transport systems, permease component
HMPREF0833_RS06960	COG5521	maltodextrose utilization protein MalA
HMPREF0833_RS06965	COG1609	Transcriptional regulator
HMPREF0833_RS06970	COG1523	belongs to the glycosyl hydrolase 13 family
HMPREF0833_RS06975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HMPREF0833_RS06990	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HMPREF0833_RS06995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HMPREF0833_RS07000	COG1696	Membrane protein involved in D-alanine export
HMPREF0833_RS07040	COG1511	domain protein
HMPREF0833_RS07040	COG1511	domain protein
HMPREF0833_RS07055	COG1116	anion transmembrane transporter activity
HMPREF0833_RS07060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HMPREF0833_RS07065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HMPREF0833_RS07075	COG0305	Participates in initiation and elongation during chromosome replication
HMPREF0833_RS07080	COG0359	binds to the 23S rRNA
HMPREF0833_RS07095	COG0494	nUDIX hydrolase
HMPREF0833_RS07100	COG2095	MarC family integral membrane protein
HMPREF0833_RS07115	COG1760	l-serine dehydratase
HMPREF0833_RS07120	COG1760	l-serine dehydratase
HMPREF0833_RS07130	COG0741	lytic transglycosylase activity
HMPREF0833_RS07135	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HMPREF0833_RS07140	COG1122	ATPase activity
HMPREF0833_RS07145	COG1122	ATPase activity
HMPREF0833_RS07150	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HMPREF0833_RS07160	COG0612	Peptidase, M16
HMPREF0833_RS07165	COG0612	Peptidase, M16
HMPREF0833_RS07175	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HMPREF0833_RS07180	COG0517	IMP dehydrogenase activity
HMPREF0833_RS07180	COG0516	GMP reductase activity
HMPREF0833_RS07185	COG0180	Tryptophanyl-tRNA synthetase
HMPREF0833_RS07190	COG0488	(ABC) transporter
HMPREF0833_RS07215	COG3290	protein histidine kinase activity
HMPREF0833_RS07225	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HMPREF0833_RS07230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HMPREF0833_RS07235	COG1475	DNA binding
HMPREF0833_RS07245	COG0592	DNA-directed DNA polymerase activity
HMPREF0833_RS07260	COG0012	GTP binding
HMPREF0833_RS07270	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HMPREF0833_RS07275	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HMPREF0833_RS07290	COG0037	tRNA processing
HMPREF0833_RS07295	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HMPREF0833_RS07300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HMPREF0833_RS07430	COG1792	Involved in formation and maintenance of cell shape
HMPREF0833_RS07440	COG3942	CHAP domain
HMPREF0833_RS07445	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HMPREF0833_RS07455	COG4509	Sortase family
HMPREF0833_RS07460	COG0436	Aminotransferase
HMPREF0833_RS07465	COG1381	Involved in DNA repair and RecF pathway recombination
HMPREF0833_RS07470	COG0416	fatty acid biosynthetic process
HMPREF0833_RS07475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HMPREF0833_RS07485	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HMPREF0833_RS07500	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HMPREF0833_RS07510	COG3942	CHAP domain
HMPREF0833_RS07515	COG0151	Belongs to the GarS family
HMPREF0833_RS07520	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HMPREF0833_RS07540	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HMPREF0833_RS07545	COG2188	Transcriptional regulator
HMPREF0833_RS07555	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF0833_RS07565	COG3716	PTS system mannose fructose sorbose family IID component
HMPREF0833_RS07575	COG2222	sugar isomerase
HMPREF0833_RS07585	COG2255	four-way junction helicase activity
HMPREF0833_RS07595	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HMPREF0833_RS07605	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HMPREF0833_RS07605	COG2755	lipolytic protein G-D-S-L family
HMPREF0833_RS07610	COG1454	alcohol dehydrogenase
HMPREF0833_RS07610	COG1012	belongs to the aldehyde dehydrogenase family
HMPREF0833_RS07630	COG1063	alcohol dehydrogenase
HMPREF0833_RS07640	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HMPREF0833_RS07650	COG1175	transmembrane transport
HMPREF0833_RS07655	COG0395	ABC-type sugar transport system, permease component
HMPREF0833_RS07660	COG2731	YhcH YjgK YiaL family protein
HMPREF0833_RS07670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HMPREF0833_RS07690	COG1269	ATP hydrolysis coupled proton transport
HMPREF0833_RS07695	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HMPREF0833_RS07705	COG1527	subunit (C
HMPREF0833_RS07710	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
HMPREF0833_RS07720	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HMPREF0833_RS07725	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HMPREF0833_RS07730	COG1394	ATPase activity, coupled to movement of substances
HMPREF0833_RS07735	COG3409	Peptidoglycan-binding domain 1 protein
HMPREF0833_RS07735	COG5632	N-Acetylmuramoyl-L-alanine amidase
HMPREF0833_RS07740	COG2807	transmembrane transport
HMPREF0833_RS07755	COG0640	Transcriptional regulator
HMPREF0833_RS07770	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HMPREF0833_RS07790	COG2151	metal-sulfur cluster biosynthetic enzyme
HMPREF0833_RS07805	COG0534	Mate efflux family protein
HMPREF0833_RS07815	COG1846	Transcriptional regulator
HMPREF0833_RS07820	COG3759	membrane
HMPREF0833_RS07825	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HMPREF0833_RS07830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HMPREF0833_RS07860	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HMPREF0833_RS07860	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HMPREF0833_RS07865	COG1832	CoA-binding protein
HMPREF0833_RS07890	COG0088	Forms part of the polypeptide exit tunnel
HMPREF0833_RS07900	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HMPREF0833_RS07905	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HMPREF0833_RS07925	COG0255	Belongs to the universal ribosomal protein uL29 family
HMPREF0833_RS07930	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HMPREF0833_RS07935	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HMPREF0833_RS07940	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HMPREF0833_RS07945	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HMPREF0833_RS07950	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HMPREF0833_RS07955	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HMPREF0833_RS07970	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HMPREF0833_RS07975	COG1841	ribosomal large subunit assembly
HMPREF0833_RS07980	COG0200	Binds to the 23S rRNA
HMPREF0833_RS07985	COG0201	protein transport
HMPREF0833_RS07995	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HMPREF0833_RS08000	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HMPREF0833_RS08005	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HMPREF0833_RS08010	COG0202	RNA polymerase activity
HMPREF0833_RS08015	COG0203	ribosomal protein L17
HMPREF0833_RS08130	COG1846	Transcriptional regulator
HMPREF0833_RS08135	COG1121	(ABC) transporter
HMPREF0833_RS08140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HMPREF0833_RS08145	COG0803	Belongs to the bacterial solute-binding protein 9 family
HMPREF0833_RS08145	COG3443	Belongs to the bacterial solute-binding protein 9 family
HMPREF0833_RS08155	COG3537	Alpha-1,2-mannosidase
HMPREF0833_RS08165	COG0383	alpha-mannosidase activity
HMPREF0833_RS08180	COG4209	transmembrane transport
HMPREF0833_RS08185	COG0395	ABC-type sugar transport system, permease component
HMPREF0833_RS08190	COG1653	transport
HMPREF0833_RS08200	COG2972	Histidine kinase
HMPREF0833_RS08215	COG2249	NAD(P)H dehydrogenase (quinone) activity
HMPREF0833_RS08220	COG0500	methyltransferase
HMPREF0833_RS08240	COG3279	Response regulator of the LytR AlgR family
HMPREF0833_RS08255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HMPREF0833_RS08255	COG4499	WXG100 protein secretion system (Wss), protein YukC
HMPREF0833_RS08260	COG0085	RNA polymerase activity
HMPREF0833_RS08265	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HMPREF0833_RS08270	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HMPREF0833_RS08280	COG1215	transferase activity, transferring glycosyl groups
HMPREF0833_RS08285	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HMPREF0833_RS08295	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HMPREF0833_RS08300	COG1459	type II secretion system
HMPREF0833_RS08305	COG4537	Required for transformation and DNA binding
HMPREF0833_RS08330	COG0827	DNA restriction-modification system
HMPREF0833_RS08335	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HMPREF0833_RS08340	COG1266	CAAX protease self-immunity
HMPREF0833_RS08345	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HMPREF0833_RS08350	COG0285	dihydrofolate synthase activity
HMPREF0833_RS08355	COG0302	gtp cyclohydrolase
HMPREF0833_RS08360	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HMPREF0833_RS08360	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HMPREF0833_RS08365	COG4868	Belongs to the UPF0371 family
HMPREF0833_RS08370	COG1363	Peptidase, m42
HMPREF0833_RS08380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HMPREF0833_RS08385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPREF0833_RS08400	COG4585	Histidine kinase
HMPREF0833_RS08405	COG2197	response regulator
HMPREF0833_RS08430	COG3716	PTS system mannose fructose sorbose family IID component
HMPREF0833_RS08440	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HMPREF0833_RS08460	COG1131	(ABC) transporter
HMPREF0833_RS08475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HMPREF0833_RS08485	COG0494	nUDIX hydrolase
HMPREF0833_RS08495	COG2264	protein methyltransferase activity
HMPREF0833_RS08500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HMPREF0833_RS08570	COG3590	peptidase
HMPREF0833_RS08575	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HMPREF0833_RS08580	COG1349	DNA-binding transcription factor activity
HMPREF0833_RS08590	COG1447	Phosphotransferase system cellobiose-specific component IIA
HMPREF0833_RS08600	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HMPREF0833_RS08605	COG1882	Formate acetyltransferase
HMPREF0833_RS08620	COG1686	Belongs to the peptidase S11 family
HMPREF0833_RS08625	COG4166	transmembrane transport
HMPREF0833_RS08655	COG1846	Transcriptional regulator
HMPREF0833_RS08670	COG1174	glycine betaine transport
HMPREF0833_RS08675	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HMPREF0833_RS08680	COG2723	6-phospho-beta-galactosidase activity
HMPREF0833_RS08685	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HMPREF0833_RS08690	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HMPREF0833_RS08710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF0833_RS08715	COG0765	amino acid transport
HMPREF0833_RS08720	COG0765	amino acid transport
HMPREF0833_RS08725	COG1126	abc transporter atp-binding protein
HMPREF0833_RS08770	COG1862	Preprotein translocase
HMPREF0833_RS08775	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HMPREF0833_RS08780	COG4589	Belongs to the CDS family
HMPREF0833_RS08785	COG0750	zinc metalloprotease
HMPREF0833_RS08865	COG2176	DNA-directed DNA polymerase activity
HMPREF0833_RS08875	COG3041	Addiction module toxin RelE StbE family
HMPREF0833_RS08885	COG0464	growth
HMPREF0833_RS08890	COG2309	aminopeptidase activity
HMPREF0833_RS08900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HMPREF0833_RS08915	COG1187	pseudouridine synthase activity
HMPREF0833_RS08935	COG3118	belongs to the thioredoxin family
HMPREF0833_RS08950	COG1164	Oligoendopeptidase f
HMPREF0833_RS08970	COG1045	serine acetyltransferase
HMPREF0833_RS08985	COG0215	cysteine-tRNA ligase activity
HMPREF0833_RS08990	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HMPREF0833_RS09000	COG3842	ATPase activity
HMPREF0833_RS09005	COG0366	Alpha amylase catalytic
HMPREF0833_RS09025	COG3688	RNA-binding protein containing a PIN domain
HMPREF0833_RS09035	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HMPREF0833_RS09105	COG0582	viral genome integration into host DNA
HMPREF0833_RS09165	COG1131	(ABC) transporter
HMPREF0833_RS09175	COG4974	Belongs to the 'phage' integrase family
HMPREF0833_RS09185	COG1705	Flagellar rod assembly protein muramidase FlgJ
HMPREF0833_RS09185	COG3942	CHAP domain
HMPREF0833_RS09200	COG0433	COG0433 Predicted ATPase
HMPREF0833_RS09235	COG1674	ftsk spoiiie
HMPREF0833_RS09255	COG1476	TRANSCRIPTIONal
HMPREF0833_RS09280	COG3620	sequence-specific DNA binding
HMPREF0833_RS09290	COG1396	sequence-specific DNA binding
HMPREF0833_RS09320	COG2184	nucleotidyltransferase activity
HMPREF0833_RS09330	COG1476	TRANSCRIPTIONal
HMPREF0833_RS09350	COG3237	CsbD-like
HMPREF0833_RS09365	COG3830	Belongs to the UPF0237 family
HMPREF0833_RS09385	COG1876	peptidase activity
HMPREF0833_RS09395	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HMPREF0833_RS09410	COG0484	heat shock protein binding
HMPREF0833_RS09415	COG3583	domain protein
HMPREF0833_RS09415	COG3064	Membrane
HMPREF0833_RS09415	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HMPREF0833_RS09425	COG0351	phosphomethylpyrimidine kinase
HMPREF0833_RS09430	COG4720	Psort location CytoplasmicMembrane, score
HMPREF0833_RS09435	COG4475	Protein of unknown function (DUF436)
HMPREF0833_RS09440	COG0544	peptidyl-prolyl cis-trans isomerase activity
HMPREF0833_RS09445	COG3343	RNA polymerase activity
HMPREF0833_RS09455	COG0504	CTP synthase activity
HMPREF0833_RS09465	COG0191	fructose-bisphosphate aldolase activity
HMPREF0833_RS09495	COG4555	ABC transporter
HMPREF0833_RS09535	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HMPREF0833_RS09570	COG1131	(ABC) transporter
HMPREF0833_RS09575	COG0842	Transport permease protein
HMPREF0833_RS09580	COG4585	Histidine kinase
HMPREF0833_RS09585	COG2197	response regulator
HMPREF0833_RS09590	COG0028	Belongs to the TPP enzyme family
HMPREF0833_RS09595	COG0440	acetolactate synthase activity
HMPREF0833_RS09600	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HMPREF0833_RS09605	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HMPREF0833_RS09620	COG1126	abc transporter atp-binding protein
HMPREF0833_RS09625	COG0765	amino acid transport
HMPREF0833_RS09640	COG4862	establishment of competence for transformation
HMPREF0833_RS09645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HMPREF0833_RS09655	COG0719	Fe-S assembly protein
HMPREF0833_RS09660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HMPREF0833_RS09670	COG0719	Fe-S assembly protein
HMPREF0833_RS09675	COG1686	Belongs to the peptidase S11 family
HMPREF0833_RS09680	COG4166	transmembrane transport
HMPREF0833_RS09685	COG0601	transmembrane transport
HMPREF0833_RS09690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF0833_RS09695	COG0444	Belongs to the ABC transporter superfamily
HMPREF0833_RS09700	COG4608	Belongs to the ABC transporter superfamily
HMPREF0833_RS09740	COG0527	aspartate kinase activity
HMPREF0833_RS09745	COG1024	Enoyl-CoA hydratase
HMPREF0833_RS09750	COG1846	Transcriptional regulator
HMPREF0833_RS09755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HMPREF0833_RS09765	COG2070	2-Nitropropane dioxygenase
HMPREF0833_RS09770	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HMPREF0833_RS09775	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF0833_RS09780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HMPREF0833_RS09795	COG0439	Biotin carboxylase
HMPREF0833_RS09800	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HMPREF0833_RS09805	COG0825	malonyl-CoA metabolic process
HMPREF0833_RS09820	COG3716	PTS system mannose fructose sorbose family IID component
HMPREF0833_RS09825	COG3715	PTS system
HMPREF0833_RS09835	COG1064	alcohol dehydrogenase
HMPREF0833_RS09840	COG0561	phosphatase activity
HMPREF0833_RS09845	COG2252	PERMEase
HMPREF0833_RS09850	COG0802	atpase or kinase
HMPREF0833_RS09855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HMPREF0833_RS09860	COG1316	TRANSCRIPTIONal
HMPREF0833_RS09870	COG0537	adenosine 5'-monophosphoramidase activity
HMPREF0833_RS09875	COG1131	(ABC) transporter
HMPREF0833_RS09890	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HMPREF0833_RS09895	COG0779	Required for maturation of 30S ribosomal subunits
HMPREF0833_RS09900	COG0195	Participates in both transcription termination and antitermination
HMPREF0833_RS09905	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HMPREF0833_RS09925	COG1283	sodium-dependent phosphate transmembrane transporter activity
HMPREF0833_RS09940	COG0656	L-ascorbic acid biosynthetic process
HMPREF0833_RS09965	COG1113	amino acid transport
HMPREF0833_RS09985	COG0768	penicillin binding
HMPREF0833_RS09995	COG0513	Belongs to the DEAD box helicase family
HMPREF0833_RS10000	COG0765	amino acid transport
HMPREF0833_RS10005	COG1126	abc transporter atp-binding protein
HMPREF0833_RS10015	COG0492	ferredoxin-NADP+ reductase activity
HMPREF0833_RS10020	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HMPREF0833_RS10030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HMPREF0833_RS10035	COG3579	cysteine-type endopeptidase activity
HMPREF0833_RS10040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HMPREF0833_RS10045	COG3331	DNA recombination
HMPREF0833_RS10050	COG4474	Belongs to the UPF0398 family
HMPREF0833_RS10055	COG3599	regulation of cell shape
HMPREF0833_RS10060	COG0116	Belongs to the methyltransferase superfamily
HMPREF0833_RS10070	COG1854	S-ribosylhomocysteine lyase activity
HMPREF0833_RS10075	COG1418	mRNA catabolic process
HMPREF0833_RS10080	COG0194	GDP metabolic process
HMPREF0833_RS10085	COG1758	RNA polymerase activity
HMPREF0833_RS10090	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HMPREF0833_RS10095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HMPREF0833_RS10100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HMPREF0833_RS10100	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HMPREF0833_RS10105	COG0631	protein serine/threonine phosphatase activity
HMPREF0833_RS10110	COG2815	serine threonine protein kinase
HMPREF0833_RS10110	COG0515	serine threonine protein kinase
HMPREF0833_RS10125	COG4585	Histidine kinase
HMPREF0833_RS10130	COG2197	response regulator
HMPREF0833_RS10140	COG1098	S1 RNA binding domain