locus-tag	class	description
SPAF_RS00010	COG0592	DNA-directed DNA polymerase activity
SPAF_RS00025	COG0012	GTP binding
SPAF_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPAF_RS00040	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPAF_RS00055	COG0037	tRNA processing
SPAF_RS00060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SPAF_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPAF_RS00200	COG1792	Involved in formation and maintenance of cell shape
SPAF_RS00210	COG3942	CHAP domain
SPAF_RS00220	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPAF_RS00230	COG4509	Sortase family
SPAF_RS00235	COG0436	Aminotransferase
SPAF_RS00240	COG1381	Involved in DNA repair and RecF pathway recombination
SPAF_RS00245	COG0416	fatty acid biosynthetic process
SPAF_RS00250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPAF_RS00260	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPAF_RS00265	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SPAF_RS00275	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPAF_RS00290	COG3942	CHAP domain
SPAF_RS00295	COG0151	Belongs to the GarS family
SPAF_RS00300	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPAF_RS00325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPAF_RS00330	COG2188	Transcriptional regulator
SPAF_RS00340	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPAF_RS00350	COG3716	PTS system mannose fructose sorbose family IID component
SPAF_RS00360	COG2222	sugar isomerase
SPAF_RS00385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPAF_RS00395	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SPAF_RS00395	COG2755	lipolytic protein G-D-S-L family
SPAF_RS00400	COG1012	belongs to the aldehyde dehydrogenase family
SPAF_RS00400	COG1454	alcohol dehydrogenase
SPAF_RS00420	COG1063	alcohol dehydrogenase
SPAF_RS00430	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SPAF_RS00440	COG1175	transmembrane transport
SPAF_RS00445	COG0395	ABC-type sugar transport system, permease component
SPAF_RS00450	COG2731	YhcH YjgK YiaL family protein
SPAF_RS00460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPAF_RS00480	COG1269	ATP hydrolysis coupled proton transport
SPAF_RS00485	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPAF_RS00495	COG1527	subunit (C
SPAF_RS00500	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
SPAF_RS00510	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
SPAF_RS00515	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
SPAF_RS00520	COG1394	ATPase activity, coupled to movement of substances
SPAF_RS00525	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPAF_RS00525	COG3409	Peptidoglycan-binding domain 1 protein
SPAF_RS00530	COG2807	transmembrane transport
SPAF_RS00545	COG0640	Transcriptional regulator
SPAF_RS00560	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPAF_RS00595	COG2151	metal-sulfur cluster biosynthetic enzyme
SPAF_RS00610	COG0534	Mate efflux family protein
SPAF_RS00620	COG1846	Transcriptional regulator
SPAF_RS00625	COG3759	membrane
SPAF_RS00630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPAF_RS00635	COG0512	Glutamine amidotransferase of anthranilate synthase
SPAF_RS00640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SPAF_RS00670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPAF_RS00670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPAF_RS00675	COG1832	CoA-binding protein
SPAF_RS00700	COG0088	Forms part of the polypeptide exit tunnel
SPAF_RS00710	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SPAF_RS00715	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPAF_RS00735	COG0255	Belongs to the universal ribosomal protein uL29 family
SPAF_RS00740	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SPAF_RS00745	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SPAF_RS00755	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SPAF_RS00760	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SPAF_RS00765	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SPAF_RS00780	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SPAF_RS00785	COG1841	ribosomal large subunit assembly
SPAF_RS00790	COG0200	Binds to the 23S rRNA
SPAF_RS00795	COG0201	protein transport
SPAF_RS00805	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SPAF_RS00810	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SPAF_RS00815	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SPAF_RS00820	COG0202	RNA polymerase activity
SPAF_RS00825	COG0203	ribosomal protein L17
SPAF_RS00860	COG2801	Transposase and inactivated derivatives
SPAF_RS00870	COG0527	aspartate kinase activity
SPAF_RS00875	COG1024	Enoyl-CoA hydratase
SPAF_RS00880	COG1846	Transcriptional regulator
SPAF_RS00885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPAF_RS00895	COG2070	2-Nitropropane dioxygenase
SPAF_RS00900	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPAF_RS00905	COG1028	Short-chain dehydrogenase reductase Sdr
SPAF_RS00910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPAF_RS00925	COG0439	Biotin carboxylase
SPAF_RS00930	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPAF_RS00935	COG0825	malonyl-CoA metabolic process
SPAF_RS00950	COG3716	PTS system mannose fructose sorbose family IID component
SPAF_RS00955	COG3715	PTS system
SPAF_RS00965	COG1064	alcohol dehydrogenase
SPAF_RS00970	COG0561	phosphatase activity
SPAF_RS00975	COG2252	PERMEase
SPAF_RS00980	COG0802	atpase or kinase
SPAF_RS00985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPAF_RS00990	COG1316	TRANSCRIPTIONal
SPAF_RS01000	COG0537	adenosine 5'-monophosphoramidase activity
SPAF_RS01005	COG1131	(ABC) transporter
SPAF_RS01020	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SPAF_RS01025	COG0779	Required for maturation of 30S ribosomal subunits
SPAF_RS01030	COG0195	Participates in both transcription termination and antitermination
SPAF_RS01035	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPAF_RS01055	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPAF_RS01070	COG0656	L-ascorbic acid biosynthetic process
SPAF_RS01095	COG1113	amino acid transport
SPAF_RS01115	COG0768	penicillin binding
SPAF_RS01125	COG0513	Belongs to the DEAD box helicase family
SPAF_RS01135	COG1126	abc transporter atp-binding protein
SPAF_RS01145	COG0492	ferredoxin-NADP+ reductase activity
SPAF_RS01150	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPAF_RS01165	COG3579	cysteine-type endopeptidase activity
SPAF_RS01175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPAF_RS01180	COG3331	DNA recombination
SPAF_RS01185	COG4474	Belongs to the UPF0398 family
SPAF_RS01190	COG3599	regulation of cell shape
SPAF_RS01195	COG0116	Belongs to the methyltransferase superfamily
SPAF_RS01210	COG1854	S-ribosylhomocysteine lyase activity
SPAF_RS01215	COG1418	mRNA catabolic process
SPAF_RS01220	COG0194	GDP metabolic process
SPAF_RS01225	COG1758	RNA polymerase activity
SPAF_RS01230	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPAF_RS01235	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SPAF_RS01240	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPAF_RS01240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPAF_RS01245	COG0631	protein serine/threonine phosphatase activity
SPAF_RS01250	COG0515	serine threonine protein kinase
SPAF_RS01250	COG2815	serine threonine protein kinase
SPAF_RS01265	COG4585	Histidine kinase
SPAF_RS01270	COG2197	response regulator
SPAF_RS01280	COG1098	S1 RNA binding domain
SPAF_RS01290	COG1739	Uncharacterized protein family UPF0029
SPAF_RS01295	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPAF_RS01300	COG1040	competence protein
SPAF_RS01390	COG0582	viral genome integration into host DNA
SPAF_RS01425	COG1846	Transcriptional regulator
SPAF_RS01430	COG1121	(ABC) transporter
SPAF_RS01435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPAF_RS01440	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPAF_RS01440	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPAF_RS01455	COG3537	Alpha-1,2-mannosidase
SPAF_RS01465	COG0383	alpha-mannosidase activity
SPAF_RS01480	COG4209	transmembrane transport
SPAF_RS01485	COG0395	ABC-type sugar transport system, permease component
SPAF_RS01490	COG1653	transport
SPAF_RS01500	COG2972	Histidine kinase
SPAF_RS01505	COG2207	Transcriptional regulator
SPAF_RS01505	COG4753	response regulator
SPAF_RS01510	COG1309	transcriptional regulator
SPAF_RS01515	COG2249	NAD(P)H dehydrogenase (quinone) activity
SPAF_RS01520	COG0500	methyltransferase
SPAF_RS01540	COG3279	Response regulator of the LytR AlgR family
SPAF_RS01555	COG4499	WXG100 protein secretion system (Wss), protein YukC
SPAF_RS01555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPAF_RS01560	COG0085	RNA polymerase activity
SPAF_RS01565	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SPAF_RS01570	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SPAF_RS01580	COG1215	transferase activity, transferring glycosyl groups
SPAF_RS01585	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
SPAF_RS01595	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPAF_RS01600	COG1459	type II secretion system
SPAF_RS01605	COG4537	Required for transformation and DNA binding
SPAF_RS01630	COG0827	DNA restriction-modification system
SPAF_RS01635	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SPAF_RS01640	COG1266	CAAX protease self-immunity
SPAF_RS01645	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SPAF_RS01650	COG0285	dihydrofolate synthase activity
SPAF_RS01655	COG0302	gtp cyclohydrolase
SPAF_RS01660	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SPAF_RS01660	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPAF_RS01665	COG4868	Belongs to the UPF0371 family
SPAF_RS01670	COG1363	Peptidase, m42
SPAF_RS01680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPAF_RS01685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPAF_RS01700	COG4585	Histidine kinase
SPAF_RS01705	COG2197	response regulator
SPAF_RS01730	COG3716	PTS system mannose fructose sorbose family IID component
SPAF_RS01740	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SPAF_RS01765	COG1131	(ABC) transporter
SPAF_RS01775	COG1609	Transcriptional regulator
SPAF_RS01780	COG0561	phosphatase activity
SPAF_RS01785	COG2855	membrane
SPAF_RS01815	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPAF_RS01835	COG2264	protein methyltransferase activity
SPAF_RS01840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPAF_RS01915	COG3590	peptidase
SPAF_RS01920	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPAF_RS01925	COG1349	DNA-binding transcription factor activity
SPAF_RS01935	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPAF_RS01945	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPAF_RS01950	COG1882	Formate acetyltransferase
SPAF_RS01965	COG1686	Belongs to the peptidase S11 family
SPAF_RS01970	COG4166	transmembrane transport
SPAF_RS01985	COG1846	Transcriptional regulator
SPAF_RS02000	COG1174	glycine betaine transport
SPAF_RS02010	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPAF_RS02015	COG2723	6-phospho-beta-galactosidase activity
SPAF_RS02020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPAF_RS02025	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SPAF_RS02045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPAF_RS02050	COG0765	amino acid transport
SPAF_RS02055	COG0765	amino acid transport
SPAF_RS02060	COG1126	abc transporter atp-binding protein
SPAF_RS02110	COG1862	Preprotein translocase
SPAF_RS02115	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPAF_RS02120	COG4589	Belongs to the CDS family
SPAF_RS02125	COG0750	zinc metalloprotease
SPAF_RS02195	COG2176	DNA-directed DNA polymerase activity
SPAF_RS02205	COG3041	Addiction module toxin RelE StbE family
SPAF_RS02215	COG0464	growth
SPAF_RS02220	COG2309	aminopeptidase activity
SPAF_RS02230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPAF_RS02245	COG1187	pseudouridine synthase activity
SPAF_RS02275	COG1164	Oligoendopeptidase f
SPAF_RS02305	COG1045	serine acetyltransferase
SPAF_RS02315	COG0215	cysteine-tRNA ligase activity
SPAF_RS02320	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPAF_RS02330	COG3842	ATPase activity
SPAF_RS02335	COG0366	Alpha amylase catalytic
SPAF_RS02355	COG3688	RNA-binding protein containing a PIN domain
SPAF_RS02365	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPAF_RS02370	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SPAF_RS02380	COG2217	Heavy metal translocating P-type atpase
SPAF_RS02405	COG1476	TRANSCRIPTIONal
SPAF_RS02425	COG3237	CsbD-like
SPAF_RS02435	COG1063	alcohol dehydrogenase
SPAF_RS02440	COG1309	transcriptional regulator
SPAF_RS02450	COG3830	Belongs to the UPF0237 family
SPAF_RS02470	COG1876	peptidase activity
SPAF_RS02480	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SPAF_RS02495	COG0484	heat shock protein binding
SPAF_RS02500	COG3583	domain protein
SPAF_RS02500	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPAF_RS02500	COG3064	Membrane
SPAF_RS02510	COG0351	phosphomethylpyrimidine kinase
SPAF_RS02515	COG4720	Psort location CytoplasmicMembrane, score
SPAF_RS02525	COG0544	peptidyl-prolyl cis-trans isomerase activity
SPAF_RS02530	COG3343	RNA polymerase activity
SPAF_RS02540	COG0504	CTP synthase activity
SPAF_RS02555	COG0191	fructose-bisphosphate aldolase activity
SPAF_RS02585	COG4555	ABC transporter
SPAF_RS02620	COG0464	growth
SPAF_RS02650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SPAF_RS02675	COG1131	(ABC) transporter
SPAF_RS02680	COG0842	Transport permease protein
SPAF_RS02685	COG4585	Histidine kinase
SPAF_RS02690	COG2197	response regulator
SPAF_RS02695	COG0028	Belongs to the TPP enzyme family
SPAF_RS02700	COG0440	acetolactate synthase activity
SPAF_RS02705	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SPAF_RS02710	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SPAF_RS02725	COG1126	abc transporter atp-binding protein
SPAF_RS02730	COG0765	amino acid transport
SPAF_RS02745	COG4862	establishment of competence for transformation
SPAF_RS02750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPAF_RS02760	COG0719	Fe-S assembly protein
SPAF_RS02765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPAF_RS02775	COG0719	Fe-S assembly protein
SPAF_RS02780	COG1686	Belongs to the peptidase S11 family
SPAF_RS02785	COG4166	transmembrane transport
SPAF_RS02790	COG0601	transmembrane transport
SPAF_RS02795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPAF_RS02800	COG0444	Belongs to the ABC transporter superfamily
SPAF_RS02805	COG4608	Belongs to the ABC transporter superfamily
SPAF_RS02890	COG3557	Belongs to the UPF0374 family
SPAF_RS02900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPAF_RS02940	COG0519	Catalyzes the synthesis of GMP from XMP
SPAF_RS02960	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SPAF_RS02965	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPAF_RS02970	COG1534	Rna-binding protein
SPAF_RS02975	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SPAF_RS02980	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPAF_RS02985	COG1335	isochorismatase
SPAF_RS02990	COG0799	negative regulation of ribosome biogenesis
SPAF_RS02995	COG2226	methyltransferase
SPAF_RS03015	COG0217	transcriptional regulatory protein
SPAF_RS03030	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPAF_RS03035	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SPAF_RS03045	COG0742	ribosomal rna small subunit methyltransferase
SPAF_RS03050	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SPAF_RS03055	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPAF_RS03060	COG0785	Cytochrome C biogenesis protein
SPAF_RS03070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPAF_RS03075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPAF_RS03075	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPAF_RS03080	COG4753	response regulator
SPAF_RS03080	COG2207	Transcriptional regulator
SPAF_RS03085	COG2972	Histidine kinase
SPAF_RS03090	COG4470	Protein conserved in bacteria
SPAF_RS03095	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SPAF_RS03105	COG0133	tryptophan synthase activity
SPAF_RS03110	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SPAF_RS03120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPAF_RS03125	COG1187	pseudouridine synthase activity
SPAF_RS03130	COG1217	gtp-binding protein TYPA
SPAF_RS03150	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SPAF_RS03160	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SPAF_RS03165	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPAF_RS03170	COG1799	cell septum assembly
SPAF_RS03185	COG3599	regulation of cell shape
SPAF_RS03190	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SPAF_RS03200	COG0494	nUDIX hydrolase
SPAF_RS03205	COG0542	response to heat
SPAF_RS03210	COG4703	Protein of unknown function (DUF1797)
SPAF_RS03215	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPAF_RS03225	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SPAF_RS03240	COG1175	transmembrane transport
SPAF_RS03245	COG0395	ABC-type sugar transport system, permease component
SPAF_RS03250	COG1621	beta-fructofuranosidase activity
SPAF_RS03260	COG1570	exodeoxyribonuclease VII activity
SPAF_RS03265	COG1722	exodeoxyribonuclease VII activity
SPAF_RS03275	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPAF_RS03280	COG1438	arginine binding
SPAF_RS03285	COG0497	DNA recombination
SPAF_RS03290	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SPAF_RS03295	COG1307	EDD domain protein, DegV family
SPAF_RS03305	COG0735	belongs to the Fur family
SPAF_RS03310	COG0588	phosphoglycerate mutase activity
SPAF_RS03315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPAF_RS03315	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPAF_RS03320	COG3655	Transcriptional regulator
SPAF_RS03335	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPAF_RS03350	COG0745	RESPONSE REGULATOR receiver
SPAF_RS03355	COG2205	protein histidine kinase activity
SPAF_RS03360	COG1136	(ABC) transporter
SPAF_RS03365	COG0577	efflux transmembrane transporter activity
SPAF_RS03395	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SPAF_RS03405	COG0732	type I restriction modification DNA specificity domain
SPAF_RS03455	COG0477	Major facilitator Superfamily
SPAF_RS03460	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPAF_RS03480	COG1136	(ABC) transporter
SPAF_RS03485	COG0577	efflux transmembrane transporter activity
SPAF_RS03490	COG4166	transmembrane transport
SPAF_RS03495	COG1695	Transcriptional regulator
SPAF_RS03510	COG0531	amino acid
SPAF_RS03520	COG1028	Short-chain dehydrogenase reductase Sdr
SPAF_RS03565	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SPAF_RS03570	COG0494	nUDIX hydrolase
SPAF_RS03580	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPAF_RS03585	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPAF_RS03590	COG4166	transmembrane transport
SPAF_RS03600	COG0708	Exodeoxyribonuclease III
SPAF_RS03610	COG2323	membrane
SPAF_RS03615	COG0768	penicillin binding
SPAF_RS03620	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SPAF_RS03630	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPAF_RS03635	COG1051	belongs to the nudix hydrolase family
SPAF_RS03655	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SPAF_RS03675	COG0513	Belongs to the DEAD box helicase family
SPAF_RS03685	COG2827	Endonuclease containing a URI domain
SPAF_RS03690	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPAF_RS03695	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SPAF_RS03700	COG0204	Acyl-transferase
SPAF_RS03705	COG1596	polysaccharide export
SPAF_RS03705	COG1555	photosystem II stabilization
SPAF_RS03710	COG2333	competence protein COMEC
SPAF_RS03710	COG0658	competence protein
SPAF_RS03725	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SPAF_RS03730	COG0433	COG0433 Predicted ATPase
SPAF_RS03745	COG2235	arginine
SPAF_RS03750	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SPAF_RS03755	COG0549	Belongs to the carbamate kinase family
SPAF_RS03760	COG1288	antiporter activity
SPAF_RS03765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPAF_RS03770	COG1438	arginine binding
SPAF_RS03775	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SPAF_RS03785	COG1686	Belongs to the peptidase S11 family
SPAF_RS03810	COG4122	O-methyltransferase activity
SPAF_RS03815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SPAF_RS03825	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SPAF_RS03830	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPAF_RS03835	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPAF_RS03840	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPAF_RS03845	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPAF_RS03855	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SPAF_RS03865	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SPAF_RS03870	COG0297	glycogen (starch) synthase activity
SPAF_RS03875	COG3064	Membrane
SPAF_RS03885	COG0356	it plays a direct role in the translocation of protons across the membrane
SPAF_RS03890	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SPAF_RS03895	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPAF_RS03900	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SPAF_RS03905	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SPAF_RS03915	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SPAF_RS03925	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPAF_RS03945	COG0488	(ABC) transporter
SPAF_RS03960	COG2814	Major facilitator Superfamily
SPAF_RS03975	COG3442	glutamine amidotransferase
SPAF_RS03980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPAF_RS03985	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPAF_RS03995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPAF_RS04000	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SPAF_RS04010	COG0251	oxidation-reduction process
SPAF_RS04015	COG1660	Displays ATPase and GTPase activities
SPAF_RS04020	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SPAF_RS04025	COG1481	regulation of sporulation
SPAF_RS04030	COG0492	ferredoxin-NADP+ reductase activity
SPAF_RS04035	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SPAF_RS04040	COG1970	mechanosensitive ion channel activity
SPAF_RS04045	COG0358	DNA primase activity
SPAF_RS04050	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPAF_RS04055	COG2151	metal-sulfur cluster biosynthetic enzyme
SPAF_RS04060	COG1131	(ABC) transporter
SPAF_RS04085	COG0469	pyruvate kinase activity
SPAF_RS04095	COG0765	amino acid transport
SPAF_RS04100	COG1126	abc transporter atp-binding protein
SPAF_RS04110	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPAF_RS04135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPAF_RS04140	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SPAF_RS04145	COG0196	riboflavin kinase activity
SPAF_RS04150	COG1393	Belongs to the ArsC family
SPAF_RS04160	COG0483	inositol monophosphate 1-phosphatase activity
SPAF_RS04165	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPAF_RS04165	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPAF_RS04170	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPAF_RS04175	COG0573	inorganic phosphate transmembrane transporter activity
SPAF_RS04180	COG0581	inorganic phosphate transmembrane transporter activity
SPAF_RS04185	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPAF_RS04190	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPAF_RS04195	COG0704	Plays a role in the regulation of phosphate uptake
SPAF_RS04210	COG3279	Response regulator of the LytR AlgR family
SPAF_RS04215	COG1131	(ABC) transporter
SPAF_RS04225	COG1268	BioY protein
SPAF_RS04235	COG0745	RESPONSE REGULATOR receiver
SPAF_RS04240	COG5002	protein histidine kinase activity
SPAF_RS04250	COG0726	polysaccharide deacetylase
SPAF_RS04260	COG0673	inositol 2-dehydrogenase activity
SPAF_RS04265	COG0463	Glycosyl transferase, family 2
SPAF_RS04270	COG1091	dTDP-4-dehydrorhamnose reductase activity
SPAF_RS04280	COG1216	Glycosyl transferase, family 2
SPAF_RS04285	COG0463	Glycosyl transferase, family 2
SPAF_RS04305	COG1215	transferase activity, transferring glycosyl groups
SPAF_RS04335	COG1368	sulfuric ester hydrolase activity
SPAF_RS04350	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SPAF_RS04360	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SPAF_RS04365	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SPAF_RS04370	COG2131	deaminase
SPAF_RS04380	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPAF_RS04385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPAF_RS04390	COG4109	DRTGG domain
SPAF_RS04395	COG0024	Methionine aminopeptidase
SPAF_RS04405	COG1846	Transcriptional regulator
SPAF_RS04420	COG4708	membrane
SPAF_RS04425	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SPAF_RS04430	COG1597	lipid kinase activity
SPAF_RS04435	COG1523	belongs to the glycosyl hydrolase 13 family
SPAF_RS04440	COG1368	sulfuric ester hydrolase activity
SPAF_RS04445	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPAF_RS04450	COG0710	3-dehydroquinate dehydratase activity
SPAF_RS04455	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPAF_RS04460	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SPAF_RS04465	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SPAF_RS04470	COG0287	Prephenate dehydrogenase
SPAF_RS04475	COG3679	Belongs to the UPF0342 family
SPAF_RS04480	COG2271	Major facilitator Superfamily
SPAF_RS04485	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPAF_RS04490	COG0738	Major facilitator superfamily
SPAF_RS04495	COG0710	3-dehydroquinate dehydratase activity
SPAF_RS04500	COG1902	pentaerythritol trinitrate reductase activity
SPAF_RS04505	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SPAF_RS04510	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SPAF_RS04515	COG0077	Prephenate dehydratase
SPAF_RS04525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPAF_RS04580	COG1132	(ABC) transporter
SPAF_RS04600	COG1131	(ABC) transporter
SPAF_RS04605	COG0789	Transcriptional regulator
SPAF_RS04635	COG3620	sequence-specific DNA binding
SPAF_RS04660	COG2184	nucleotidyltransferase activity
SPAF_RS04720	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SPAF_RS04740	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPAF_RS04770	COG0716	FMN binding
SPAF_RS04780	COG0038	chloride channel
SPAF_RS04785	COG0335	large ribosomal subunit rRNA binding
SPAF_RS04825	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SPAF_RS04835	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SPAF_RS04850	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SPAF_RS04855	COG0038	chloride channel
SPAF_RS04865	COG0813	purine-nucleoside phosphorylase activity
SPAF_RS04880	COG0583	DNA-binding transcription factor activity
SPAF_RS04890	COG0543	2 iron, 2 sulfur cluster binding
SPAF_RS04895	COG0167	dihydroorotate dehydrogenase activity
SPAF_RS04900	COG0284	orotidine-5'-phosphate decarboxylase activity
SPAF_RS04920	COG1051	belongs to the nudix hydrolase family
SPAF_RS04925	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPAF_RS04930	COG2755	lipolytic protein G-D-S-L family
SPAF_RS04960	COG0066	3-isopropylmalate dehydratase activity
SPAF_RS04975	COG0187	DNA topoisomerase II activity
SPAF_RS04985	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPAF_RS04990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPAF_RS05010	COG0539	negative regulation of cytoplasmic translation
SPAF_RS05030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPAF_RS05035	COG3764	Sortase (surface protein transpeptidase)
SPAF_RS05045	COG2003	Belongs to the UPF0758 family
SPAF_RS05070	COG1104	cysteine desulfurase activity
SPAF_RS05075	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPAF_RS05080	COG4116	CYTH
SPAF_RS05085	COG2357	RelA SpoT domain protein
SPAF_RS05095	COG0564	pseudouridine synthase activity
SPAF_RS05100	COG0280	phosphate acetyltransferase
SPAF_RS05105	COG2801	Transposase and inactivated derivatives
SPAF_RS05115	COG1194	a g-specific adenine glycosylase
SPAF_RS05125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPAF_RS05130	COG4684	Psort location CytoplasmicMembrane, score
SPAF_RS05135	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPAF_RS05150	COG0534	Mate efflux family protein
SPAF_RS05170	COG0785	Cytochrome C biogenesis protein
SPAF_RS05180	COG1053	succinate dehydrogenase
SPAF_RS05180	COG0431	NADPH-dependent FMN reductase
SPAF_RS05180	COG3976	FMN-binding domain protein
SPAF_RS05210	COG2837	iron assimilation
SPAF_RS05215	COG0672	)-iron permease
SPAF_RS05220	COG0805	protein transport
SPAF_RS05225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SPAF_RS05245	COG2233	PERMEase
SPAF_RS05250	COG0534	Mate efflux family protein
SPAF_RS05255	COG0129	dihydroxy-acid dehydratase activity
SPAF_RS05260	COG1942	4-Oxalocrotonate Tautomerase
SPAF_RS05265	COG1435	thymidine kinase activity
SPAF_RS05270	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SPAF_RS05275	COG2890	protein-(glutamine-N5) methyltransferase activity
SPAF_RS05295	COG0741	lytic transglycosylase activity
SPAF_RS05310	COG2188	Transcriptional regulator
SPAF_RS05320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SPAF_RS05335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPAF_RS05340	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SPAF_RS05345	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPAF_RS05355	COG3458	cephalosporin-C deacetylase activity
SPAF_RS05395	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPAF_RS05405	COG0095	Lipoate-protein ligase
SPAF_RS05410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPAF_RS05415	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPAF_RS05420	COG0022	dehydrogenase e1 component
SPAF_RS05425	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPAF_RS05460	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPAF_RS05465	COG0758	DNA mediated transformation
SPAF_RS05470	COG1940	carbohydrate kinase activity
SPAF_RS05480	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPAF_RS05490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPAF_RS05495	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPAF_RS05515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPAF_RS05525	COG1132	(ABC) transporter
SPAF_RS05550	COG4974	Belongs to the 'phage' integrase family
SPAF_RS05560	COG1396	sequence-specific DNA binding
SPAF_RS05575	COG1131	(ABC) transporter
SPAF_RS05590	COG3843	relaxase mobilization nuclease domain protein
SPAF_RS05605	COG0613	PHP domain protein
SPAF_RS05610	COG0542	response to heat
SPAF_RS05615	COG1396	sequence-specific DNA binding
SPAF_RS05665	COG0745	RESPONSE REGULATOR receiver
SPAF_RS05670	COG2205	protein histidine kinase activity
SPAF_RS05795	COG0270	DNA (cytosine-5-)-methyltransferase activity
SPAF_RS05810	COG0222	ribosome binding
SPAF_RS05815	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SPAF_RS05825	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPAF_RS05825	COG1388	LysM domain
SPAF_RS05845	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPAF_RS05855	COG1940	carbohydrate kinase activity
SPAF_RS05865	COG0488	(ABC) transporter
SPAF_RS05870	COG0617	tRNA 3'-terminal CCA addition
SPAF_RS05875	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SPAF_RS05880	COG1307	EDD domain protein, DegV family
SPAF_RS05900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPAF_RS05900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPAF_RS05900	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPAF_RS05905	COG1105	Belongs to the carbohydrate kinase PfkB family
SPAF_RS05910	COG1349	DNA-binding transcription factor activity
SPAF_RS05930	COG1837	Belongs to the UPF0109 family
SPAF_RS05940	COG1011	Hydrolase
SPAF_RS05970	COG0561	phosphatase activity
SPAF_RS05975	COG2195	Cleaves the N-terminal amino acid of tripeptides
SPAF_RS05980	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SPAF_RS05985	COG0505	Belongs to the CarA family
SPAF_RS05990	COG0540	Belongs to the ATCase OTCase family
SPAF_RS05995	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SPAF_RS06005	COG2824	Alkylphosphonate utilization operon protein PhnA
SPAF_RS06020	COG1051	belongs to the nudix hydrolase family
SPAF_RS06070	COG0765	amino acid transport
SPAF_RS06075	COG1126	abc transporter atp-binding protein
SPAF_RS06080	COG1132	(ABC) transporter
SPAF_RS06085	COG1132	(ABC) transporter
SPAF_RS06100	COG0017	Asparaginyl-tRNA synthetase
SPAF_RS06105	COG0436	Aminotransferase
SPAF_RS06115	COG1846	Transcriptional regulator
SPAF_RS06125	COG3022	response to hydroperoxide
SPAF_RS06135	COG1272	protein, Hemolysin III
SPAF_RS06140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPAF_RS06150	COG1132	(ABC) transporter
SPAF_RS06155	COG1132	(ABC) transporter
SPAF_RS06160	COG2315	Protein conserved in bacteria
SPAF_RS06165	COG3142	Participates in the control of copper homeostasis
SPAF_RS06175	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPAF_RS06180	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPAF_RS06185	COG3845	ABC transporter
SPAF_RS06190	COG1744	ABC transporter substrate-binding protein PnrA-like
SPAF_RS06200	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SPAF_RS06210	COG2813	Specifically methylates the guanine in position
SPAF_RS06215	COG1072	(Pantothenic acid kinase))
SPAF_RS06225	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SPAF_RS06255	COG1573	uracil-dna glycosylase
SPAF_RS06290	COG0647	UMP catabolic process
SPAF_RS06305	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPAF_RS06310	COG0488	(ABC) transporter
SPAF_RS06315	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPAF_RS06320	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SPAF_RS06330	COG0564	pseudouridine synthase activity
SPAF_RS06335	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPAF_RS06340	COG0583	DNA-binding transcription factor activity
SPAF_RS06360	COG3711	transcriptional antiterminator
SPAF_RS06375	COG0698	ribose 5-phosphate isomerase
SPAF_RS06385	COG3775	system Galactitol-specific IIC component
SPAF_RS06400	COG1349	DNA-binding transcription factor activity
SPAF_RS06405	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SPAF_RS06420	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
SPAF_RS06425	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SPAF_RS06430	COG0517	IMP dehydrogenase activity
SPAF_RS06435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPAF_RS06435	COG0574	Belongs to the PEP-utilizing enzyme family
SPAF_RS06445	COG1104	cysteine desulfurase activity
SPAF_RS06480	COG1177	transmembrane transport
SPAF_RS06485	COG1177	transmembrane transport
SPAF_RS06490	COG3842	ATPase activity
SPAF_RS06510	COG0460	homoserine dehydrogenase
SPAF_RS06520	COG1418	mRNA catabolic process
SPAF_RS06540	COG1131	(ABC) transporter
SPAF_RS06545	COG4187	Peptidase family M20/M25/M40
SPAF_RS06560	COG3118	belongs to the thioredoxin family
SPAF_RS06570	COG0165	Argininosuccinate lyase
SPAF_RS06575	COG0137	argininosuccinate synthase activity
SPAF_RS06580	COG4166	transmembrane transport
SPAF_RS06585	COG1363	Peptidase, m42
SPAF_RS06630	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
SPAF_RS06640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPAF_RS06650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPAF_RS06660	COG1472	Belongs to the glycosyl hydrolase 3 family
SPAF_RS06665	COG0366	Alpha amylase catalytic
SPAF_RS06670	COG0395	ABC-type sugar transport system, permease component
SPAF_RS06675	COG1175	transmembrane transport
SPAF_RS06680	COG1653	transport
SPAF_RS06685	COG3345	alpha-galactosidase
SPAF_RS06690	COG2207	Transcriptional regulator
SPAF_RS06695	COG1609	Transcriptional regulator
SPAF_RS06705	COG1442	glycosyl transferase family 8
SPAF_RS06705	COG1216	Glycosyl transferase, family 2
SPAF_RS06710	COG5002	protein histidine kinase activity
SPAF_RS06715	COG0745	RESPONSE REGULATOR receiver
SPAF_RS06725	COG1136	(ABC) transporter
SPAF_RS06745	COG0395	ABC-type sugar transport system, permease component
SPAF_RS06750	COG4209	transmembrane transport
SPAF_RS06755	COG3275	phosphorelay sensor kinase activity
SPAF_RS06760	COG2169	Transcriptional regulator
SPAF_RS06770	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPAF_RS06785	COG0572	uridine kinase
SPAF_RS06805	COG2223	nitrite transmembrane transporter activity
SPAF_RS06810	COG2207	Transcriptional regulator
SPAF_RS06820	COG1088	dTDP-glucose 4,6-dehydratase activity
SPAF_RS06830	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SPAF_RS06840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPAF_RS06850	COG2384	SAM-dependent methyltransferase
SPAF_RS06855	COG0625	glutathione transferase activity
SPAF_RS06860	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SPAF_RS06875	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SPAF_RS06880	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPAF_RS06895	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPAF_RS06895	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPAF_RS06910	COG0300	oxidoreductase activity
SPAF_RS06925	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPAF_RS06940	COG1074	ATP-dependent DNA helicase activity
SPAF_RS06945	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SPAF_RS06950	COG0386	Belongs to the glutathione peroxidase family
SPAF_RS06965	COG1132	(ABC) transporter
SPAF_RS06970	COG1132	(ABC) transporter
SPAF_RS07000	COG4989	oxidoreductase activity
SPAF_RS07025	COG1668	transmembrane transport
SPAF_RS07030	COG4152	abc transporter atp-binding protein
SPAF_RS07040	COG1476	TRANSCRIPTIONal
SPAF_RS07065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPAF_RS07065	COG0072	phenylalanine-tRNA ligase activity
SPAF_RS07090	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPAF_RS07095	COG3527	Alpha-acetolactate decarboxylase
SPAF_RS07100	COG0457	Tetratricopeptide repeat
SPAF_RS07105	COG0628	permease
SPAF_RS07110	COG2706	6-phosphogluconolactonase activity
SPAF_RS07135	COG0560	Phosphoserine phosphatase
SPAF_RS07140	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SPAF_RS07145	COG0187	DNA topoisomerase II activity
SPAF_RS07150	COG0546	phosphoglycolate phosphatase activity
SPAF_RS07160	COG0772	Belongs to the SEDS family
SPAF_RS07165	COG2855	membrane
SPAF_RS07170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SPAF_RS07170	COG1199	ATP-dependent helicase activity
SPAF_RS07180	COG2177	Part of the ABC transporter FtsEX involved in
SPAF_RS07185	COG2884	Cell division ATP-binding protein ftsE
SPAF_RS07190	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SPAF_RS07210	COG1078	dGTPase activity
SPAF_RS07220	COG2348	transferase activity, transferring amino-acyl groups
SPAF_RS07235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SPAF_RS07240	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SPAF_RS07245	COG0772	Belongs to the SEDS family
SPAF_RS07255	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SPAF_RS07270	COG0577	efflux transmembrane transporter activity
SPAF_RS07275	COG1136	(ABC) transporter
SPAF_RS07280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPAF_RS07285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPAF_RS07290	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
SPAF_RS07295	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SPAF_RS07300	COG4443	Transcriptional Coactivator p15 (PC4)
SPAF_RS07310	COG0826	peptidase U32
SPAF_RS07340	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SPAF_RS07345	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SPAF_RS07370	COG2183	response to ionizing radiation
SPAF_RS07375	COG0701	Predicted permease
SPAF_RS07380	COG3689	TIGRFAM TIGR03943 family protein
SPAF_RS07385	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPAF_RS07390	COG0552	protein localization to endoplasmic reticulum
SPAF_RS07395	COG0561	phosphatase activity
SPAF_RS07400	COG0561	phosphatase activity
SPAF_RS07405	COG1196	nuclear chromosome segregation
SPAF_RS07410	COG0571	ribonuclease III activity
SPAF_RS07415	COG2832	Protein of unknown function (DUF454)
SPAF_RS07420	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPAF_RS07425	COG5002	protein histidine kinase activity
SPAF_RS07430	COG0745	RESPONSE REGULATOR receiver
SPAF_RS07440	COG0438	transferase activity, transferring glycosyl groups
SPAF_RS07450	COG1609	Transcriptional regulator
SPAF_RS07455	COG0006	proline dipeptidase activity
SPAF_RS07465	COG2801	Transposase and inactivated derivatives
SPAF_RS07475	COG1959	2 iron, 2 sulfur cluster binding
SPAF_RS07490	COG0577	efflux transmembrane transporter activity
SPAF_RS07490	COG1136	(ABC) transporter
SPAF_RS07495	COG1914	H( )-stimulated, divalent metal cation uptake system
SPAF_RS07510	COG0500	methyltransferase
SPAF_RS07510	COG3615	Tellurite resistance protein tehB
SPAF_RS07520	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SPAF_RS07525	COG0557	exoribonuclease II activity
SPAF_RS07535	COG2814	Major facilitator Superfamily
SPAF_RS07540	COG0237	dephospho-CoA kinase activity
SPAF_RS07545	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPAF_RS07555	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPAF_RS07565	COG1132	(ABC) transporter
SPAF_RS07570	COG1132	(ABC) transporter
SPAF_RS07585	COG0686	Belongs to the AlaDH PNT family
SPAF_RS07590	COG1702	phosphate starvation-inducible protein PhoH
SPAF_RS07610	COG0528	UMP kinase activity
SPAF_RS07615	COG0081	regulation of translation
SPAF_RS07620	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SPAF_RS07630	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SPAF_RS07635	COG0346	lactoylglutathione lyase activity
SPAF_RS07640	COG0697	spore germination
SPAF_RS07640	COG1674	ftsk spoiiie
SPAF_RS07665	COG0488	(ABC) transporter
SPAF_RS07670	COG1393	Belongs to the ArsC family
SPAF_RS07675	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SPAF_RS07690	COG4467	Involved in initiation control of chromosome replication
SPAF_RS07695	COG0470	DNA polymerase III
SPAF_RS07700	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SPAF_RS07705	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPAF_RS07710	COG0517	IMP dehydrogenase activity
SPAF_RS07710	COG0617	tRNA 3'-terminal CCA addition
SPAF_RS07710	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPAF_RS07750	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SPAF_RS07760	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SPAF_RS07765	COG0626	cystathionine gamma-synthase activity
SPAF_RS07770	COG2244	polysaccharide biosynthetic process
SPAF_RS07775	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPAF_RS07795	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPAF_RS07805	COG0366	Alpha amylase catalytic
SPAF_RS07810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPAF_RS07810	COG1263	PTS System
SPAF_RS07815	COG2188	Transcriptional regulator
SPAF_RS07820	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPAF_RS07825	COG4120	Belongs to the binding-protein-dependent transport system permease family
SPAF_RS07835	COG1253	flavin adenine dinucleotide binding
SPAF_RS07840	COG3711	transcriptional antiterminator
SPAF_RS07845	COG0628	permease
SPAF_RS07850	COG1119	ATPase activity
SPAF_RS07885	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPAF_RS07890	COG1242	4 iron, 4 sulfur cluster binding
SPAF_RS07895	COG0671	phosphoesterase, PA-phosphatase related
SPAF_RS07900	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPAF_RS07910	COG0569	domain protein
SPAF_RS07925	COG1187	pseudouridine synthase activity
SPAF_RS07930	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SPAF_RS07935	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SPAF_RS07940	COG4974	Belongs to the 'phage' integrase family
SPAF_RS07945	COG0517	IMP dehydrogenase activity
SPAF_RS07960	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SPAF_RS07985	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPAF_RS07990	COG1254	Belongs to the acylphosphatase family
SPAF_RS08005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SPAF_RS08010	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPAF_RS08035	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPAF_RS08045	COG0778	Nitroreductase
SPAF_RS08050	COG1484	DNA-dependent DNA replication
SPAF_RS08060	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPAF_RS08070	COG2190	(PTS) system
SPAF_RS08070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPAF_RS08070	COG1263	PTS System
SPAF_RS08075	COG0745	RESPONSE REGULATOR receiver
SPAF_RS08080	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SPAF_RS08085	COG2268	Band 7 protein
SPAF_RS08110	COG0501	Belongs to the peptidase M48B family
SPAF_RS08115	COG1704	LemA family
SPAF_RS08120	COG0357	Ribosomal RNA small subunit methyltransferase G
SPAF_RS08125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPAF_RS08130	COG4221	oxidoreductase activity
SPAF_RS08140	COG1122	ATPase activity
SPAF_RS08210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPAF_RS08215	COG1473	amidohydrolase
SPAF_RS08230	COG1063	alcohol dehydrogenase
SPAF_RS08255	COG1335	isochorismatase
SPAF_RS08260	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SPAF_RS08265	COG0436	Aminotransferase
SPAF_RS08270	COG0589	response to stress
SPAF_RS08275	COG0561	phosphatase activity
SPAF_RS08280	COG0252	asparaginase activity
SPAF_RS08285	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPAF_RS08290	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SPAF_RS08295	COG0736	holo-[acyl-carrier-protein] synthase activity
SPAF_RS08300	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPAF_RS08305	COG0653	protein targeting
SPAF_RS08310	COG0531	amino acid
SPAF_RS08315	COG0789	Transcriptional regulator
SPAF_RS08320	COG1482	cell wall glycoprotein biosynthetic process
SPAF_RS08325	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SPAF_RS08340	COG0242	peptide deformylase activity
SPAF_RS08345	COG1940	carbohydrate kinase activity
SPAF_RS08350	COG2190	(PTS) system
SPAF_RS08350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPAF_RS08350	COG1263	PTS System
SPAF_RS08355	COG1621	beta-fructofuranosidase activity
SPAF_RS08360	COG1609	Transcriptional regulator
SPAF_RS08380	COG0006	proline dipeptidase activity
SPAF_RS08385	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPAF_RS08430	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPAF_RS08435	COG0629	single-stranded DNA binding
SPAF_RS08465	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SPAF_RS08465	COG1404	Belongs to the peptidase S8 family
SPAF_RS08475	COG0737	Belongs to the 5'-nucleotidase family
SPAF_RS08480	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SPAF_RS08485	COG1228	amidohydrolase
SPAF_RS08490	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SPAF_RS08500	COG3404	Formiminotransferase-cyclodeaminase
SPAF_RS08515	COG0531	amino acid
SPAF_RS08520	COG2986	histidine ammonia-lyase
SPAF_RS08545	COG0366	Alpha amylase catalytic
SPAF_RS08560	COG0569	domain protein
SPAF_RS08565	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPAF_RS08580	COG1349	DNA-binding transcription factor activity
SPAF_RS08585	COG0561	phosphatase activity
SPAF_RS08600	COG0583	DNA-binding transcription factor activity
SPAF_RS08605	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SPAF_RS08615	COG1230	cation diffusion facilitator family transporter
SPAF_RS08655	COG1122	ATPase activity
SPAF_RS08665	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPAF_RS08680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPAF_RS08700	COG2205	protein histidine kinase activity
SPAF_RS08705	COG0745	RESPONSE REGULATOR receiver
SPAF_RS08710	COG2723	6-phospho-beta-galactosidase activity
SPAF_RS08715	COG0657	acetylesterase activity
SPAF_RS08715	COG2755	lipolytic protein G-D-S-L family
SPAF_RS08720	COG3250	beta-galactosidase activity
SPAF_RS08725	COG2211	Major facilitator Superfamily
SPAF_RS08730	COG2207	Transcriptional regulator
SPAF_RS08730	COG1917	Cupin 2, conserved barrel domain protein
SPAF_RS08745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPAF_RS08750	COG3507	Belongs to the glycosyl hydrolase 43 family
SPAF_RS08755	COG1454	alcohol dehydrogenase
SPAF_RS08760	COG0235	Class ii aldolase
SPAF_RS08785	COG0028	Belongs to the TPP enzyme family
SPAF_RS08810	COG0561	phosphatase activity
SPAF_RS08820	COG1811	Na channel or pump
SPAF_RS08825	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SPAF_RS08835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPAF_RS08835	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPAF_RS08845	COG0167	dihydroorotate dehydrogenase activity
SPAF_RS08850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPAF_RS08870	COG0668	transmembrane transport
SPAF_RS08875	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
SPAF_RS08880	COG1115	amino acid carrier protein
SPAF_RS08890	COG1193	negative regulation of DNA recombination
SPAF_RS08910	COG0681	Belongs to the peptidase S26 family
SPAF_RS08915	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPAF_RS08920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPAF_RS08925	COG1882	Formate acetyltransferase
SPAF_RS08945	COG3425	synthase
SPAF_RS08980	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPAF_RS08985	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPAF_RS09010	COG2176	DNA-directed DNA polymerase activity
SPAF_RS09020	COG0582	viral genome integration into host DNA
SPAF_RS09030	COG3942	CHAP domain
SPAF_RS09030	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPAF_RS09045	COG0433	COG0433 Predicted ATPase
SPAF_RS09080	COG1674	ftsk spoiiie
SPAF_RS09100	COG1476	TRANSCRIPTIONal
SPAF_RS09125	COG3620	sequence-specific DNA binding
SPAF_RS09145	COG0577	efflux transmembrane transporter activity
SPAF_RS09145	COG1136	(ABC) transporter
SPAF_RS09185	COG2184	nucleotidyltransferase activity
SPAF_RS09195	COG1132	(ABC) transporter
SPAF_RS09205	COG1396	sequence-specific DNA binding
SPAF_RS09225	COG1346	cytolysis
SPAF_RS09230	COG1380	Effector of murein hydrolase LrgA
SPAF_RS09235	COG2081	HI0933 family
SPAF_RS09280	COG0456	acetyltransferase
SPAF_RS09285	COG1214	PFAM Peptidase M22, glycoprotease
SPAF_RS09290	COG5503	Protein of unknown function (DUF1447)
SPAF_RS09300	COG0174	glutamine synthetase
SPAF_RS09305	COG0789	Transcriptional regulator
SPAF_RS09315	COG0126	phosphoglycerate kinase activity
SPAF_RS09325	COG0366	Alpha amylase catalytic
SPAF_RS09335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SPAF_RS09355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPAF_RS09375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SPAF_RS09380	COG1162	GTPase activity
SPAF_RS09410	COG0084	hydrolase, TatD family'
SPAF_RS09425	COG1847	R3H domain protein
SPAF_RS09430	COG0706	membrane insertase activity
SPAF_RS09435	COG0594	ribonuclease P activity
SPAF_RS09475	COG1073	alpha beta
SPAF_RS09495	COG1216	Glycosyl transferase, family 2
SPAF_RS09495	COG1442	glycosyl transferase family 8
SPAF_RS09510	COG1442	glycosyl transferase family 8
SPAF_RS09510	COG1216	Glycosyl transferase, family 2
SPAF_RS09535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPAF_RS09555	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SPAF_RS09565	COG0756	dUTP diphosphatase activity
SPAF_RS09575	COG0366	Alpha amylase catalytic
SPAF_RS09580	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPAF_RS09585	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SPAF_RS09605	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPAF_RS09645	COG0166	Belongs to the GPI family
SPAF_RS09675	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SPAF_RS09690	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPAF_RS09705	COG3201	nicotinamide mononucleotide transporter
SPAF_RS09710	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SPAF_RS09730	COG0542	response to heat
SPAF_RS09735	COG4463	regulation of RNA biosynthetic process
SPAF_RS09745	COG3250	beta-galactosidase activity
SPAF_RS09770	COG2801	Transposase and inactivated derivatives
SPAF_RS09775	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SPAF_RS09810	COG2321	neutral zinc metallopeptidase
SPAF_RS09815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPAF_RS09820	COG0564	pseudouridine synthase activity
SPAF_RS09845	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SPAF_RS09870	COG3475	LICD family
SPAF_RS09875	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
SPAF_RS09880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPAF_RS09885	COG0489	protein tyrosine kinase activity
SPAF_RS09890	COG3944	biosynthesis protein
SPAF_RS09895	COG4464	protein tyrosine phosphatase activity
SPAF_RS09900	COG1316	TRANSCRIPTIONal
SPAF_RS09905	COG0602	queuosine metabolic process
SPAF_RS09915	COG1328	CTP reductase activity
SPAF_RS09925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPAF_RS09935	COG0285	dihydrofolate synthase activity
SPAF_RS09940	COG3906	Belongs to the UPF0473 family
SPAF_RS09945	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SPAF_RS09950	COG4472	Bacterial protein of unknown function (DUF965)
SPAF_RS09960	COG1393	Belongs to the ArsC family
SPAF_RS09970	COG1546	Belongs to the CinA family
SPAF_RS09970	COG1058	Belongs to the CinA family
SPAF_RS09975	COG0519	Catalyzes the synthesis of GMP from XMP
SPAF_RS09985	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SPAF_RS10000	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SPAF_RS10005	COG1438	arginine binding
SPAF_RS10010	COG0018	arginyl-trna synthetase
SPAF_RS10015	COG1780	Probably involved in ribonucleotide reductase function
SPAF_RS10030	COG0058	SHG alpha-glucan phosphorylase activity
SPAF_RS10035	COG1640	4-alpha-glucanotransferase
SPAF_RS10040	COG2182	Extracellular solute-binding protein
SPAF_RS10045	COG1175	transmembrane transport
SPAF_RS10055	COG5521	maltodextrose utilization protein MalA
SPAF_RS10060	COG1609	Transcriptional regulator
SPAF_RS10065	COG1523	belongs to the glycosyl hydrolase 13 family
SPAF_RS10070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPAF_RS10085	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPAF_RS10090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPAF_RS10095	COG1696	Membrane protein involved in D-alanine export
SPAF_RS10135	COG1511	domain protein
SPAF_RS10135	COG1511	domain protein
SPAF_RS10150	COG1116	anion transmembrane transporter activity
SPAF_RS10155	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SPAF_RS10160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SPAF_RS10170	COG0305	Participates in initiation and elongation during chromosome replication
SPAF_RS10175	COG0359	binds to the 23S rRNA
SPAF_RS10190	COG0494	nUDIX hydrolase
SPAF_RS10205	COG1760	l-serine dehydratase
SPAF_RS10210	COG1760	l-serine dehydratase
SPAF_RS10220	COG0741	lytic transglycosylase activity
SPAF_RS10225	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPAF_RS10230	COG1122	ATPase activity
SPAF_RS10235	COG1122	ATPase activity
SPAF_RS10240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPAF_RS10250	COG0612	Peptidase, M16
SPAF_RS10255	COG0612	Peptidase, M16
SPAF_RS10265	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SPAF_RS10270	COG0517	IMP dehydrogenase activity
SPAF_RS10270	COG0516	GMP reductase activity
SPAF_RS10275	COG0180	Tryptophanyl-tRNA synthetase
SPAF_RS10280	COG0488	(ABC) transporter
SPAF_RS10305	COG3290	protein histidine kinase activity
SPAF_RS10315	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SPAF_RS10320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPAF_RS10325	COG1475	DNA binding