locus-tag	class	description
N2A95_RS00005	COG1475	DNA binding
N2A95_RS00010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N2A95_RS00040	COG0488	(ABC) transporter
N2A95_RS00045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N2A95_RS00055	COG0516	GMP reductase activity
N2A95_RS00055	COG0517	IMP dehydrogenase activity
N2A95_RS00075	COG0612	Peptidase, M16
N2A95_RS00085	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N2A95_RS00105	COG0741	lytic transglycosylase activity
N2A95_RS00115	COG1760	l-serine dehydratase
N2A95_RS00120	COG1760	l-serine dehydratase
N2A95_RS00150	COG0359	binds to the 23S rRNA
N2A95_RS00155	COG0305	Participates in initiation and elongation during chromosome replication
N2A95_RS00190	COG1309	transcriptional regulator
N2A95_RS00195	COG3759	membrane
N2A95_RS00210	COG1695	Transcriptional regulator
N2A95_RS00220	COG0701	Predicted permease
N2A95_RS00230	COG1250	3-hydroxyacyl-CoA dehydrogenase
N2A95_RS00235	COG1960	acyl-CoA dehydrogenase activity
N2A95_RS00240	COG0183	Belongs to the thiolase family
N2A95_RS00245	COG1250	3-hydroxyacyl-CoA dehydrogenase
N2A95_RS00250	COG0318	PFAM AMP-dependent synthetase and ligase
N2A95_RS00260	COG2508	Transcriptional regulator
N2A95_RS00285	COG2816	NAD+ diphosphatase activity
N2A95_RS00320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N2A95_RS00325	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N2A95_RS00330	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N2A95_RS00335	COG0018	arginyl-trna synthetase
N2A95_RS00340	COG1438	arginine binding
N2A95_RS00350	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
N2A95_RS00455	COG0582	viral genome integration into host DNA
N2A95_RS00470	COG0632	four-way junction helicase activity
N2A95_RS00475	COG0519	Catalyzes the synthesis of GMP from XMP
N2A95_RS00485	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
N2A95_RS00490	COG1393	Belongs to the ArsC family
N2A95_RS00495	COG4472	Bacterial protein of unknown function (DUF965)
N2A95_RS00500	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N2A95_RS00505	COG3906	Belongs to the UPF0473 family
N2A95_RS00515	COG1328	CTP reductase activity
N2A95_RS00535	COG0602	queuosine metabolic process
N2A95_RS00540	COG3022	response to hydroperoxide
N2A95_RS00545	COG2514	catechol 2,3-dioxygenase activity
N2A95_RS00550	COG1733	regulation of RNA biosynthetic process
N2A95_RS00555	COG2188	Transcriptional regulator
N2A95_RS00560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N2A95_RS00560	COG1263	PTS System
N2A95_RS00565	COG0366	Alpha amylase catalytic
N2A95_RS00570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N2A95_RS00585	COG3959	Transketolase, thiamine diphosphate binding domain
N2A95_RS00590	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N2A95_RS00595	COG3590	peptidase
N2A95_RS00600	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N2A95_RS00615	COG0450	alkyl hydroperoxide reductase
N2A95_RS00635	COG0400	carboxylic ester hydrolase activity
N2A95_RS00640	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N2A95_RS00645	COG0346	lactoylglutathione lyase activity
N2A95_RS00650	COG0346	lactoylglutathione lyase activity
N2A95_RS00655	COG0025	NhaP-type Na H and K H
N2A95_RS00685	COG0459	protein refolding
N2A95_RS00715	COG0564	pseudouridine synthase activity
N2A95_RS00730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N2A95_RS00755	COG0495	leucyl-tRNA aminoacylation
N2A95_RS00760	COG1929	Belongs to the glycerate kinase type-1 family
N2A95_RS00785	COG3623	hexulose-6-phosphate isomerase
N2A95_RS00810	COG3448	diguanylate cyclase activity
N2A95_RS00810	COG4175	Glycine betaine
N2A95_RS00820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N2A95_RS00820	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N2A95_RS00825	COG1832	CoA-binding protein
N2A95_RS00840	COG0343	queuine tRNA-ribosyltransferase activity
N2A95_RS00850	COG1268	BioY protein
N2A95_RS00855	COG1234	tRNA 3'-trailer cleavage
N2A95_RS00875	COG0166	Belongs to the GPI family
N2A95_RS00885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N2A95_RS00885	COG3711	transcriptional antiterminator
N2A95_RS00895	COG3730	PTS system glucitol sorbitol-specific
N2A95_RS00900	COG3732	PTS system glucitol sorbitol-specific
N2A95_RS00910	COG2171	N-acyltransferase activity
N2A95_RS00915	COG1473	amidohydrolase
N2A95_RS00920	COG1215	transferase activity, transferring glycosyl groups
N2A95_RS00925	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
N2A95_RS00935	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N2A95_RS00945	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N2A95_RS00950	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N2A95_RS00960	COG1132	(ABC) transporter
N2A95_RS00965	COG1132	(ABC) transporter
N2A95_RS00970	COG0431	NADPH-dependent FMN reductase
N2A95_RS00970	COG3976	FMN-binding domain protein
N2A95_RS00970	COG1053	succinate dehydrogenase
N2A95_RS00980	COG2832	Protein of unknown function (DUF454)
N2A95_RS00985	COG0756	dUTP diphosphatase activity
N2A95_RS01020	COG3290	protein histidine kinase activity
N2A95_RS01045	COG0165	Argininosuccinate lyase
N2A95_RS01050	COG0594	ribonuclease P activity
N2A95_RS01060	COG1847	R3H domain protein
N2A95_RS01070	COG1131	(ABC) transporter
N2A95_RS01095	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
N2A95_RS01105	COG0395	ABC-type sugar transport system, permease component
N2A95_RS01110	COG1653	transport
N2A95_RS01120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N2A95_RS01135	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N2A95_RS01135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N2A95_RS01135	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N2A95_RS01140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N2A95_RS01140	COG3711	transcriptional antiterminator
N2A95_RS01145	COG0084	hydrolase, TatD family'
N2A95_RS01160	COG2226	methyltransferase
N2A95_RS01170	COG2814	Major facilitator Superfamily
N2A95_RS01205	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N2A95_RS01215	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
N2A95_RS01225	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N2A95_RS01230	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N2A95_RS01235	COG0126	phosphoglycerate kinase activity
N2A95_RS01245	COG0789	Transcriptional regulator
N2A95_RS01250	COG0174	glutamine synthetase
N2A95_RS01255	COG4166	transmembrane transport
N2A95_RS01260	COG0601	transmembrane transport
N2A95_RS01265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N2A95_RS01270	COG0444	Belongs to the ABC transporter superfamily
N2A95_RS01275	COG4608	Belongs to the ABC transporter superfamily
N2A95_RS01285	COG5503	Protein of unknown function (DUF1447)
N2A95_RS01290	COG1214	PFAM Peptidase M22, glycoprotease
N2A95_RS01310	COG2081	HI0933 family
N2A95_RS01320	COG2176	DNA-directed DNA polymerase activity
N2A95_RS01330	COG1609	Transcriptional regulator
N2A95_RS01335	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
N2A95_RS01345	COG1028	Short-chain dehydrogenase reductase Sdr
N2A95_RS01355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N2A95_RS01365	COG2348	transferase activity, transferring amino-acyl groups
N2A95_RS01370	COG0673	inositol 2-dehydrogenase activity
N2A95_RS01380	COG2814	Major facilitator Superfamily
N2A95_RS01385	COG2723	6-phospho-beta-galactosidase activity
N2A95_RS01395	COG3655	Transcriptional regulator
N2A95_RS01420	COG2828	Protein conserved in bacteria
N2A95_RS01425	COG2851	Citrate transporter
N2A95_RS01430	COG0583	DNA-binding transcription factor activity
N2A95_RS01435	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
N2A95_RS01440	COG3180	Ammonia monooxygenase
N2A95_RS01445	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
N2A95_RS01455	COG2851	Citrate transporter
N2A95_RS01465	COG0511	ligase activity, forming carbon-carbon bonds
N2A95_RS01470	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
N2A95_RS01480	COG3052	prosthetic group binding
N2A95_RS01505	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
N2A95_RS01520	COG1609	Transcriptional regulator
N2A95_RS01525	COG4209	transmembrane transport
N2A95_RS01530	COG0395	ABC-type sugar transport system, permease component
N2A95_RS01545	COG1940	carbohydrate kinase activity
N2A95_RS01565	COG2936	dipeptidyl-peptidase activity
N2A95_RS01585	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N2A95_RS01595	COG2153	protein acetylation
N2A95_RS01600	COG1882	Formate acetyltransferase
N2A95_RS01615	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N2A95_RS01620	COG0681	Belongs to the peptidase S26 family
N2A95_RS01625	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N2A95_RS01640	COG1193	negative regulation of DNA recombination
N2A95_RS01645	COG3118	belongs to the thioredoxin family
N2A95_RS01655	COG1194	a g-specific adenine glycosylase
N2A95_RS01690	COG0006	proline dipeptidase activity
N2A95_RS01695	COG2131	deaminase
N2A95_RS01710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N2A95_RS01715	COG1609	Transcriptional regulator
N2A95_RS01720	COG1621	beta-fructofuranosidase activity
N2A95_RS01725	COG1263	PTS System
N2A95_RS01725	COG2190	(PTS) system
N2A95_RS01725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N2A95_RS01730	COG1940	carbohydrate kinase activity
N2A95_RS01740	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N2A95_RS01745	COG2723	6-phospho-beta-galactosidase activity
N2A95_RS01750	COG1482	cell wall glycoprotein biosynthetic process
N2A95_RS01760	COG0653	protein targeting
N2A95_RS01765	COG0736	holo-[acyl-carrier-protein] synthase activity
N2A95_RS01770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N2A95_RS01775	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N2A95_RS01780	COG4989	oxidoreductase activity
N2A95_RS01785	COG0252	asparaginase activity
N2A95_RS01790	COG0561	phosphatase activity
N2A95_RS01795	COG0589	response to stress
N2A95_RS01800	COG0436	Aminotransferase
N2A95_RS01805	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
N2A95_RS01810	COG1335	isochorismatase
N2A95_RS01815	COG1937	Protein conserved in bacteria
N2A95_RS01820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N2A95_RS01825	COG0446	pyridine nucleotide-disulphide oxidoreductase
N2A95_RS01900	COG1252	NADH dehydrogenase
N2A95_RS01905	COG1271	oxidase subunit
N2A95_RS01910	COG1294	oxidase, subunit
N2A95_RS01915	COG4988	ABC transporter
N2A95_RS01920	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
N2A95_RS01925	COG0142	geranyltranstransferase activity
N2A95_RS01930	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
N2A95_RS01940	COG1121	(ABC) transporter
N2A95_RS01945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N2A95_RS01955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N2A95_RS01955	COG4499	WXG100 protein secretion system (Wss), protein YukC
N2A95_RS01965	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N2A95_RS01975	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N2A95_RS01980	COG1459	type II secretion system
N2A95_RS02015	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N2A95_RS02030	COG1266	CAAX protease self-immunity
N2A95_RS02035	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N2A95_RS02040	COG1363	Peptidase, m42
N2A95_RS02050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N2A95_RS02055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N2A95_RS02075	COG4120	Belongs to the binding-protein-dependent transport system permease family
N2A95_RS02080	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N2A95_RS02085	COG1428	Deoxynucleoside kinase
N2A95_RS02090	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N2A95_RS02110	COG1181	Belongs to the D-alanine--D-alanine ligase family
N2A95_RS02110	COG2918	glutathione biosynthetic process
N2A95_RS02125	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N2A95_RS02140	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
N2A95_RS02145	COG1349	DNA-binding transcription factor activity
N2A95_RS02150	COG2390	Transcriptional regulator
N2A95_RS02160	COG1882	Formate acetyltransferase
N2A95_RS02175	COG2076	Multidrug Resistance protein
N2A95_RS02180	COG1175	transmembrane transport
N2A95_RS02185	COG0395	ABC-type sugar transport system, permease component
N2A95_RS02205	COG3842	ATPase activity
N2A95_RS02225	COG1309	transcriptional regulator
N2A95_RS02230	COG1785	Belongs to the alkaline phosphatase family
N2A95_RS02250	COG1175	transmembrane transport
N2A95_RS02255	COG0395	ABC-type sugar transport system, permease component
N2A95_RS02260	COG3250	beta-galactosidase activity
N2A95_RS02270	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
N2A95_RS02290	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N2A95_RS02330	COG1131	(ABC) transporter
N2A95_RS02335	COG1131	(ABC) transporter
N2A95_RS02365	COG4978	Transcriptional regulator
N2A95_RS02365	COG0789	Transcriptional regulator
N2A95_RS02385	COG1694	Mazg nucleotide pyrophosphohydrolase
N2A95_RS02390	COG2094	Belongs to the DNA glycosylase MPG family
N2A95_RS02405	COG4978	Transcriptional regulator
N2A95_RS02405	COG0789	Transcriptional regulator
N2A95_RS02410	COG2217	Heavy metal translocating P-type atpase
N2A95_RS02420	COG0583	DNA-binding transcription factor activity
N2A95_RS02425	COG0281	malic enzyme
N2A95_RS02460	COG2946	Replication initiation factor
N2A95_RS02475	COG1002	Type II restriction enzyme, methylase subunits
N2A95_RS02490	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N2A95_RS02515	COG2264	protein methyltransferase activity
N2A95_RS02520	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N2A95_RS02540	COG1609	Transcriptional regulator
N2A95_RS02545	COG1263	PTS System
N2A95_RS02545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N2A95_RS02545	COG2190	(PTS) system
N2A95_RS02560	COG1363	Peptidase, m42
N2A95_RS02580	COG1490	D-aminoacyl-tRNA deacylase activity
N2A95_RS02600	COG3842	ATPase activity
N2A95_RS02610	COG0110	maltose O-acetyltransferase activity
N2A95_RS02620	COG1609	Transcriptional regulator
N2A95_RS02625	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
N2A95_RS02630	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
N2A95_RS02635	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N2A95_RS02645	COG1862	Preprotein translocase
N2A95_RS02655	COG4589	Belongs to the CDS family
N2A95_RS02695	COG0242	peptide deformylase activity
N2A95_RS02705	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
N2A95_RS02710	COG0248	Ppx GppA phosphatase
N2A95_RS02710	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N2A95_RS02720	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N2A95_RS02735	COG1045	serine acetyltransferase
N2A95_RS02745	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
N2A95_RS02755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N2A95_RS02775	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N2A95_RS02785	COG4974	Belongs to the 'phage' integrase family
N2A95_RS02860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N2A95_RS02885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N2A95_RS02905	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
N2A95_RS02920	COG1511	domain protein
N2A95_RS02945	COG1122	ATPase activity
N2A95_RS02950	COG4720	Psort location CytoplasmicMembrane, score
N2A95_RS02990	COG0527	aspartate kinase activity
N2A95_RS02995	COG0101	tRNA pseudouridine synthase activity
N2A95_RS03000	COG0351	phosphomethylpyrimidine kinase
N2A95_RS03000	COG0352	thiamine-phosphate diphosphorylase activity
N2A95_RS03005	COG4720	Psort location CytoplasmicMembrane, score
N2A95_RS03015	COG0668	transmembrane transport
N2A95_RS03020	COG0544	peptidyl-prolyl cis-trans isomerase activity
N2A95_RS03025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N2A95_RS03030	COG3343	RNA polymerase activity
N2A95_RS03040	COG3275	phosphorelay sensor kinase activity
N2A95_RS03045	COG3279	Response regulator of the LytR AlgR family
N2A95_RS03055	COG1346	cytolysis
N2A95_RS03110	COG1126	abc transporter atp-binding protein
N2A95_RS03115	COG0765	amino acid transport
N2A95_RS03135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N2A95_RS03145	COG0719	Fe-S assembly protein
N2A95_RS03150	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N2A95_RS03160	COG0719	Fe-S assembly protein
N2A95_RS03165	COG1686	Belongs to the peptidase S11 family
N2A95_RS03175	COG1686	Belongs to the peptidase S11 family
N2A95_RS03180	COG4166	transmembrane transport
N2A95_RS03185	COG0601	transmembrane transport
N2A95_RS03190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N2A95_RS03195	COG0444	Belongs to the ABC transporter superfamily
N2A95_RS03240	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
N2A95_RS03245	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
N2A95_RS03250	COG1534	Rna-binding protein
N2A95_RS03260	COG1713	HD superfamily hydrolase involved in NAD metabolism
N2A95_RS03265	COG1335	isochorismatase
N2A95_RS03270	COG0799	negative regulation of ribosome biogenesis
N2A95_RS03275	COG2226	methyltransferase
N2A95_RS03285	COG0789	Transcriptional regulator
N2A95_RS03300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N2A95_RS03305	COG1464	Belongs to the NlpA lipoprotein family
N2A95_RS03325	COG0569	domain protein
N2A95_RS03330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N2A95_RS03335	COG0357	Ribosomal RNA small subunit methyltransferase G
N2A95_RS03340	COG1704	LemA family
N2A95_RS03345	COG0501	Belongs to the peptidase M48B family
N2A95_RS03355	COG0745	RESPONSE REGULATOR receiver
N2A95_RS03365	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N2A95_RS03375	COG1484	DNA-dependent DNA replication
N2A95_RS03385	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N2A95_RS03405	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N2A95_RS03420	COG1254	Belongs to the acylphosphatase family
N2A95_RS03425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N2A95_RS03450	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N2A95_RS03475	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
N2A95_RS03485	COG1187	pseudouridine synthase activity
N2A95_RS03490	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
N2A95_RS03500	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
N2A95_RS03505	COG0671	phosphoesterase, PA-phosphatase related
N2A95_RS03620	COG1242	4 iron, 4 sulfur cluster binding
N2A95_RS03625	COG1131	(ABC) transporter
N2A95_RS03635	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
N2A95_RS03640	COG1253	flavin adenine dinucleotide binding
N2A95_RS03645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
N2A95_RS03650	COG1227	inorganic diphosphatase activity
N2A95_RS03665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N2A95_RS03670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N2A95_RS03675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
N2A95_RS03680	COG1120	ATPase activity
N2A95_RS03690	COG2244	polysaccharide biosynthetic process
N2A95_RS03700	COG0740	serine-type endopeptidase activity
N2A95_RS03740	COG0517	IMP dehydrogenase activity
N2A95_RS03750	COG0470	DNA polymerase III
N2A95_RS03755	COG1774	PSP1 C-terminal conserved region
N2A95_RS03780	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
N2A95_RS03790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N2A95_RS03800	COG1393	Belongs to the ArsC family
N2A95_RS03815	COG0346	lactoylglutathione lyase activity
N2A95_RS03825	COG0708	Exodeoxyribonuclease III
N2A95_RS03830	COG0640	Transcriptional regulator
N2A95_RS03860	COG1114	Component of the transport system for branched-chain amino acids
N2A95_RS03875	COG1028	Short-chain dehydrogenase reductase Sdr
N2A95_RS03885	COG0673	inositol 2-dehydrogenase activity
N2A95_RS03890	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N2A95_RS03905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N2A95_RS03955	COG0081	regulation of translation
N2A95_RS03970	COG2996	Protein conserved in bacteria
N2A95_RS03990	COG1702	phosphate starvation-inducible protein PhoH
N2A95_RS03995	COG1573	uracil-dna glycosylase
N2A95_RS04000	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
N2A95_RS04005	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
N2A95_RS04015	COG0494	nUDIX hydrolase
N2A95_RS04030	COG1131	(ABC) transporter
N2A95_RS04055	COG2364	Membrane
N2A95_RS04060	COG0433	COG0433 Predicted ATPase
N2A95_RS04065	COG2814	Major facilitator Superfamily
N2A95_RS04080	COG0557	exoribonuclease II activity
N2A95_RS04085	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N2A95_RS04095	COG0346	lactoylglutathione lyase activity
N2A95_RS04100	COG0778	Nitroreductase
N2A95_RS04105	COG2723	6-phospho-beta-galactosidase activity
N2A95_RS04120	COG3711	transcriptional antiterminator
N2A95_RS04120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N2A95_RS04125	COG1447	Phosphotransferase system cellobiose-specific component IIA
N2A95_RS04135	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N2A95_RS04155	COG1609	Transcriptional regulator
N2A95_RS04170	COG0438	transferase activity, transferring glycosyl groups
N2A95_RS04175	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N2A95_RS04185	COG2376	Dihydroxyacetone kinase
N2A95_RS04195	COG2376	Dihydroxyacetone kinase
N2A95_RS04200	COG1461	Dihydroxyacetone kinase
N2A95_RS04205	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
N2A95_RS04210	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N2A95_RS04220	COG0765	amino acid transport
N2A95_RS04225	COG0765	amino acid transport
N2A95_RS04230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N2A95_RS04240	COG0745	RESPONSE REGULATOR receiver
N2A95_RS04245	COG5002	protein histidine kinase activity
N2A95_RS04250	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
N2A95_RS04255	COG0571	ribonuclease III activity
N2A95_RS04260	COG1196	nuclear chromosome segregation
N2A95_RS04265	COG0561	phosphatase activity
N2A95_RS04270	COG0561	phosphatase activity
N2A95_RS04275	COG0552	protein localization to endoplasmic reticulum
N2A95_RS04285	COG2814	Major facilitator Superfamily
N2A95_RS04290	COG3689	TIGRFAM TIGR03943 family protein
N2A95_RS04295	COG0701	Predicted permease
N2A95_RS04305	COG0346	lactoylglutathione lyase activity
N2A95_RS04310	COG0745	RESPONSE REGULATOR receiver
N2A95_RS04315	COG5002	protein histidine kinase activity
N2A95_RS04320	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N2A95_RS04325	COG0573	inorganic phosphate transmembrane transporter activity
N2A95_RS04335	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N2A95_RS04340	COG0704	Plays a role in the regulation of phosphate uptake
N2A95_RS04345	COG2183	response to ionizing radiation
N2A95_RS04350	COG3091	SprT-like family
N2A95_RS04360	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
N2A95_RS04390	COG0826	peptidase U32
N2A95_RS04400	COG4443	Transcriptional Coactivator p15 (PC4)
N2A95_RS04405	COG4166	transmembrane transport
N2A95_RS04430	COG1228	amidohydrolase
N2A95_RS04435	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
N2A95_RS04445	COG3404	Formiminotransferase-cyclodeaminase
N2A95_RS04460	COG0531	amino acid
N2A95_RS04465	COG2986	histidine ammonia-lyase
N2A95_RS04470	COG0010	Belongs to the arginase family
N2A95_RS04490	COG0406	alpha-ribazole phosphatase activity
N2A95_RS04495	COG3304	Inner membrane component domain
N2A95_RS04505	COG3859	Proton-coupled thiamine transporter YuaJ
N2A95_RS04525	COG1164	Oligoendopeptidase f
N2A95_RS04535	COG0772	Belongs to the SEDS family
N2A95_RS04555	COG2348	transferase activity, transferring amino-acyl groups
N2A95_RS04565	COG1078	dGTPase activity
N2A95_RS04585	COG0584	glycerophosphoryl diester phosphodiesterase
N2A95_RS04600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N2A95_RS04605	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
N2A95_RS04610	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N2A95_RS04620	COG2884	Cell division ATP-binding protein ftsE
N2A95_RS04625	COG2177	Part of the ABC transporter FtsEX involved in
N2A95_RS04640	COG0436	Aminotransferase
N2A95_RS04645	COG0017	Asparaginyl-tRNA synthetase
N2A95_RS04655	COG1660	Displays ATPase and GTPase activities
N2A95_RS04680	COG2188	Transcriptional regulator
N2A95_RS04685	COG2222	sugar isomerase
N2A95_RS04710	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N2A95_RS04710	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
N2A95_RS04715	COG3715	PTS system
N2A95_RS04720	COG3716	PTS system mannose fructose sorbose family IID component
N2A95_RS04740	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
N2A95_RS04745	COG2153	protein acetylation
N2A95_RS04750	COG0625	glutathione transferase activity
N2A95_RS04760	COG0716	FMN binding
N2A95_RS04765	COG1605	Chorismate mutase
N2A95_RS04765	COG0077	Prephenate dehydratase
N2A95_RS04770	COG0038	chloride channel
N2A95_RS04775	COG0335	large ribosomal subunit rRNA binding
N2A95_RS04790	COG0772	Belongs to the SEDS family
N2A95_RS04805	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
N2A95_RS04810	COG0560	Phosphoserine phosphatase
N2A95_RS04830	COG0148	phosphopyruvate hydratase activity
N2A95_RS04835	COG2031	fatty acid transporter
N2A95_RS04845	COG0183	Belongs to the thiolase family
N2A95_RS04870	COG1269	ATP hydrolysis coupled proton transport
N2A95_RS04875	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N2A95_RS04890	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
N2A95_RS04910	COG0778	Nitroreductase
N2A95_RS04920	COG4708	membrane
N2A95_RS04925	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N2A95_RS04930	COG1597	lipid kinase activity
N2A95_RS04935	COG1523	belongs to the glycosyl hydrolase 13 family
N2A95_RS04940	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
N2A95_RS04950	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N2A95_RS04955	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N2A95_RS04960	COG0297	glycogen (starch) synthase activity
N2A95_RS04965	COG0058	SHG alpha-glucan phosphorylase activity
N2A95_RS04985	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N2A95_RS04995	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N2A95_RS05000	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N2A95_RS05005	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N2A95_RS05015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N2A95_RS05040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N2A95_RS05040	COG0072	phenylalanine-tRNA ligase activity
N2A95_RS05055	COG0577	efflux transmembrane transporter activity
N2A95_RS05060	COG1136	(ABC) transporter
N2A95_RS05065	COG2321	neutral zinc metallopeptidase
N2A95_RS05070	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
N2A95_RS05075	COG1074	ATP-dependent DNA helicase activity
N2A95_RS05080	COG0436	Aminotransferase
N2A95_RS05085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N2A95_RS05095	COG1970	mechanosensitive ion channel activity
N2A95_RS05100	COG0358	DNA primase activity
N2A95_RS05105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N2A95_RS05110	COG2151	metal-sulfur cluster biosynthetic enzyme
N2A95_RS05125	COG1216	Glycosyl transferase, family 2
N2A95_RS05125	COG1442	glycosyl transferase family 8
N2A95_RS05140	COG0438	transferase activity, transferring glycosyl groups
N2A95_RS05150	COG1368	sulfuric ester hydrolase activity
N2A95_RS05165	COG2246	polysaccharide biosynthetic process
N2A95_RS05205	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N2A95_RS05210	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N2A95_RS05215	COG1368	sulfuric ester hydrolase activity
N2A95_RS05220	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
N2A95_RS05240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N2A95_RS05245	COG0285	dihydrofolate synthase activity
N2A95_RS05255	COG1104	cysteine desulfurase activity
N2A95_RS05260	COG0301	tRNA thio-modification
N2A95_RS05280	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N2A95_RS05285	COG0583	DNA-binding transcription factor activity
N2A95_RS05295	COG0564	pseudouridine synthase activity
N2A95_RS05300	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
N2A95_RS05330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N2A95_RS05335	COG1136	(ABC) transporter
N2A95_RS05340	COG0577	efflux transmembrane transporter activity
N2A95_RS05350	COG0228	four-way junction DNA binding
N2A95_RS05355	COG1837	Belongs to the UPF0109 family
N2A95_RS05365	COG1442	glycosyl transferase family 8
N2A95_RS05385	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N2A95_RS05390	COG0336	Belongs to the RNA methyltransferase TrmD family
N2A95_RS05410	COG1349	DNA-binding transcription factor activity
N2A95_RS05415	COG1105	Belongs to the carbohydrate kinase PfkB family
N2A95_RS05420	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N2A95_RS05420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N2A95_RS05420	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N2A95_RS05425	COG1705	Flagellar rod assembly protein muramidase FlgJ
N2A95_RS05425	COG3942	CHAP domain
N2A95_RS05430	COG1705	Flagellar rod assembly protein muramidase FlgJ
N2A95_RS05430	COG1388	LysM domain
N2A95_RS05450	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
N2A95_RS05460	COG0488	(ABC) transporter
N2A95_RS05475	COG1132	(ABC) transporter
N2A95_RS05480	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N2A95_RS05485	COG0242	peptide deformylase activity
N2A95_RS05525	COG3425	synthase
N2A95_RS05535	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N2A95_RS05540	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
N2A95_RS05560	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N2A95_RS05565	COG0222	ribosome binding
N2A95_RS05625	COG3942	CHAP domain
N2A95_RS05625	COG1388	LysM domain
N2A95_RS05685	COG3843	relaxase mobilization nuclease domain protein
N2A95_RS05710	COG3682	Transcriptional regulator
N2A95_RS05720	COG2217	Heavy metal translocating P-type atpase
N2A95_RS05755	COG1028	Short-chain dehydrogenase reductase Sdr
N2A95_RS05765	COG2207	Transcriptional regulator
N2A95_RS05765	COG3708	Transcriptional regulator
N2A95_RS05860	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N2A95_RS05865	COG2096	Adenosyltransferase
N2A95_RS05880	COG0783	Belongs to the Dps family
N2A95_RS05885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N2A95_RS05895	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
N2A95_RS05900	COG2217	Heavy metal translocating P-type atpase
N2A95_RS05920	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
N2A95_RS05965	COG2226	methyltransferase
N2A95_RS05975	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N2A95_RS05985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N2A95_RS05985	COG0551	DNA topoisomerase type I activity
N2A95_RS06010	COG1192	Involved in chromosome partitioning
N2A95_RS06040	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
N2A95_RS06055	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N2A95_RS06055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N2A95_RS06055	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N2A95_RS06060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N2A95_RS06090	COG3711	transcriptional antiterminator
N2A95_RS06095	COG2723	6-phospho-beta-galactosidase activity
N2A95_RS06100	COG1447	Phosphotransferase system cellobiose-specific component IIA
N2A95_RS06105	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N2A95_RS06105	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N2A95_RS06125	COG1396	sequence-specific DNA binding
N2A95_RS06135	COG4974	Belongs to the 'phage' integrase family
N2A95_RS06150	COG0463	Glycosyl transferase, family 2
N2A95_RS06165	COG1486	melibiose metabolic process
N2A95_RS06170	COG1737	Transcriptional regulator
N2A95_RS06175	COG0446	pyridine nucleotide-disulphide oxidoreductase
N2A95_RS06180	COG0366	Alpha amylase catalytic
N2A95_RS06185	COG0726	polysaccharide deacetylase
N2A95_RS06190	COG0460	homoserine dehydrogenase
N2A95_RS06195	COG0083	homoserine kinase activity
N2A95_RS06200	COG0285	dihydrofolate synthase activity
N2A95_RS06205	COG0302	gtp cyclohydrolase
N2A95_RS06225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N2A95_RS06235	COG1176	ABC-type spermidine putrescine transport system, permease component I
N2A95_RS06240	COG1177	transmembrane transport
N2A95_RS06250	COG4565	transcriptional regulatory protein
N2A95_RS06260	COG3493	citrate carrier protein
N2A95_RS06270	COG0038	chloride channel
N2A95_RS06275	COG3711	transcriptional antiterminator
N2A95_RS06280	COG1263	PTS System
N2A95_RS06280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N2A95_RS06280	COG2190	(PTS) system
N2A95_RS06290	COG2207	Transcriptional regulator
N2A95_RS06295	COG2723	6-phospho-beta-galactosidase activity
N2A95_RS06305	COG0561	phosphatase activity
N2A95_RS06310	COG2723	6-phospho-beta-galactosidase activity
N2A95_RS06320	COG0406	alpha-ribazole phosphatase activity
N2A95_RS06330	COG2723	6-phospho-beta-galactosidase activity
N2A95_RS06335	COG0628	permease
N2A95_RS06340	COG2003	Belongs to the UPF0758 family
N2A95_RS06365	COG1104	cysteine desulfurase activity
N2A95_RS06380	COG2357	RelA SpoT domain protein
N2A95_RS06390	COG0564	pseudouridine synthase activity
N2A95_RS06395	COG0280	phosphate acetyltransferase
N2A95_RS06400	COG4221	oxidoreductase activity
N2A95_RS06405	COG0477	Major facilitator Superfamily
N2A95_RS06435	COG1174	glycine betaine transport
N2A95_RS06440	COG2723	6-phospho-beta-galactosidase activity
N2A95_RS06445	COG0516	GMP reductase activity
N2A95_RS06450	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N2A95_RS06455	COG2233	PERMEase
N2A95_RS06480	COG2890	protein-(glutamine-N5) methyltransferase activity
N2A95_RS06485	COG0009	L-threonylcarbamoyladenylate synthase
N2A95_RS06495	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N2A95_RS06515	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N2A95_RS06520	COG0039	L-malate dehydrogenase activity
N2A95_RS06530	COG3764	Sortase (surface protein transpeptidase)
N2A95_RS06535	COG0346	lactoylglutathione lyase activity
N2A95_RS06545	COG0803	Belongs to the bacterial solute-binding protein 9 family
N2A95_RS06555	COG1811	Na channel or pump
N2A95_RS06565	COG0386	Belongs to the glutathione peroxidase family
N2A95_RS06575	COG2188	Transcriptional regulator
N2A95_RS06585	COG2723	6-phospho-beta-galactosidase activity
N2A95_RS06590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N2A95_RS06605	COG3104	oligopeptide transport
N2A95_RS06695	COG2188	Transcriptional regulator
N2A95_RS06710	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N2A95_RS06725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N2A95_RS06735	COG0673	inositol 2-dehydrogenase activity
N2A95_RS06750	COG0561	phosphatase activity
N2A95_RS06775	COG2723	6-phospho-beta-galactosidase activity
N2A95_RS06780	COG0604	alcohol dehydrogenase
N2A95_RS06785	COG0662	Cupin 2, conserved barrel domain protein
N2A95_RS06790	COG0431	NADPH-dependent FMN reductase
N2A95_RS06790	COG1053	succinate dehydrogenase
N2A95_RS06790	COG3976	FMN-binding domain protein
N2A95_RS06860	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N2A95_RS06860	COG2755	lipolytic protein G-D-S-L family
N2A95_RS06865	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N2A95_RS06875	COG2020	methyltransferase activity
N2A95_RS06880	COG4974	Belongs to the 'phage' integrase family
N2A95_RS06885	COG1902	pentaerythritol trinitrate reductase activity
N2A95_RS06900	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
N2A95_RS06905	COG0642	Histidine kinase
N2A95_RS06920	COG1136	(ABC) transporter
N2A95_RS06930	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
N2A95_RS06955	COG0583	DNA-binding transcription factor activity
N2A95_RS06960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N2A95_RS06965	COG0758	DNA mediated transformation
N2A95_RS06970	COG0110	maltose O-acetyltransferase activity
N2A95_RS06975	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N2A95_RS06980	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
N2A95_RS06990	COG0095	Lipoate-protein ligase
N2A95_RS06995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N2A95_RS07010	COG1272	protein, Hemolysin III
N2A95_RS07030	COG0488	(ABC) transporter
N2A95_RS07035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N2A95_RS07040	COG1328	CTP reductase activity
N2A95_RS07040	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N2A95_RS07045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N2A95_RS07050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N2A95_RS07055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N2A95_RS07065	COG2759	Belongs to the formate--tetrahydrofolate ligase family
N2A95_RS07075	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N2A95_RS07080	COG4684	Psort location CytoplasmicMembrane, score
N2A95_RS07085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N2A95_RS07090	COG1079	Belongs to the binding-protein-dependent transport system permease family
N2A95_RS07095	COG4603	Belongs to the binding-protein-dependent transport system permease family
N2A95_RS07100	COG3845	ABC transporter
N2A95_RS07105	COG1744	ABC transporter substrate-binding protein PnrA-like
N2A95_RS07110	COG0295	cytidine deaminase activity
N2A95_RS07115	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
N2A95_RS07120	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
N2A95_RS07125	COG2813	Specifically methylates the guanine in position
N2A95_RS07140	COG5002	protein histidine kinase activity
N2A95_RS07145	COG0745	RESPONSE REGULATOR receiver
N2A95_RS07155	COG0704	Plays a role in the regulation of phosphate uptake
N2A95_RS07170	COG0581	inorganic phosphate transmembrane transporter activity
N2A95_RS07175	COG0573	inorganic phosphate transmembrane transporter activity
N2A95_RS07185	COG0483	inositol monophosphate 1-phosphatase activity
N2A95_RS07190	COG4476	Belongs to the UPF0223 family
N2A95_RS07200	COG0196	riboflavin kinase activity
N2A95_RS07275	COG2261	transglycosylase associated protein
N2A95_RS07280	COG2261	transglycosylase associated protein
N2A95_RS07285	COG2261	transglycosylase associated protein
N2A95_RS07300	COG1115	amino acid carrier protein
N2A95_RS07305	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
N2A95_RS07310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N2A95_RS07315	COG1126	abc transporter atp-binding protein
N2A95_RS07320	COG0765	amino acid transport
N2A95_RS07325	COG2824	Alkylphosphonate utilization operon protein PhnA
N2A95_RS07330	COG0246	Mannitol dehydrogenase
N2A95_RS07335	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N2A95_RS07340	COG3711	transcriptional antiterminator
N2A95_RS07345	COG2213	PTS system mannitol-specific
N2A95_RS07360	COG0469	pyruvate kinase activity
N2A95_RS07365	COG0205	6-phosphofructokinase activity
N2A95_RS07375	COG1725	Transcriptional regulator
N2A95_RS07380	COG1131	(ABC) transporter
N2A95_RS07445	COG5280	Phage tail tape measure protein TP901
N2A95_RS07445	COG3953	SLT domain
N2A95_RS07690	COG0539	negative regulation of cytoplasmic translation
N2A95_RS07710	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N2A95_RS07735	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N2A95_RS07740	COG0765	amino acid transport
N2A95_RS07745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N2A95_RS07755	COG1881	PFAM PEBP family protein
N2A95_RS07815	COG1215	transferase activity, transferring glycosyl groups
N2A95_RS07820	COG0438	transferase activity, transferring glycosyl groups
N2A95_RS07825	COG0110	maltose O-acetyltransferase activity
N2A95_RS07830	COG0438	transferase activity, transferring glycosyl groups
N2A95_RS07835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N2A95_RS07840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N2A95_RS07865	COG1316	TRANSCRIPTIONal
N2A95_RS07900	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
N2A95_RS07910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N2A95_RS07920	COG0322	excinuclease ABC activity
N2A95_RS07930	COG0561	phosphatase activity
N2A95_RS07935	COG1012	belongs to the aldehyde dehydrogenase family
N2A95_RS07940	COG1011	Hydrolase
N2A95_RS07950	COG2259	Doxx family
N2A95_RS07975	COG0667	Aldo Keto reductase
N2A95_RS07980	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N2A95_RS07990	COG0789	Transcriptional regulator
N2A95_RS07995	COG1063	alcohol dehydrogenase
N2A95_RS08000	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
N2A95_RS08010	COG1028	Short-chain dehydrogenase reductase Sdr
N2A95_RS08015	COG0656	L-ascorbic acid biosynthetic process
N2A95_RS08030	COG1418	mRNA catabolic process
N2A95_RS08045	COG0481	GTPase activity
N2A95_RS08065	COG0647	UMP catabolic process
N2A95_RS08075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N2A95_RS08085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N2A95_RS08100	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N2A95_RS08105	COG3442	glutamine amidotransferase
N2A95_RS08110	COG0095	Lipoate-protein ligase
N2A95_RS08120	COG0508	dehydrogenase complex catalyzes the overall conversion of
N2A95_RS08125	COG0022	dehydrogenase e1 component
N2A95_RS08125	COG0508	dehydrogenase complex catalyzes the overall conversion of
N2A95_RS08130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
N2A95_RS08135	COG0488	(ABC) transporter
N2A95_RS08155	COG3842	ATPase activity
N2A95_RS08170	COG1293	RNA-binding protein homologous to eukaryotic snRNP
N2A95_RS08175	COG3527	Alpha-acetolactate decarboxylase
N2A95_RS08180	COG0028	Belongs to the TPP enzyme family
N2A95_RS08185	COG0457	Tetratricopeptide repeat
N2A95_RS08190	COG0628	permease
N2A95_RS08195	COG1051	belongs to the nudix hydrolase family
N2A95_RS08200	COG2706	6-phosphogluconolactonase activity
N2A95_RS08210	COG1088	dTDP-glucose 4,6-dehydratase activity
N2A95_RS08220	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
N2A95_RS08225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N2A95_RS08240	COG2384	SAM-dependent methyltransferase
N2A95_RS08250	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N2A95_RS08260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N2A95_RS08265	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N2A95_RS08265	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
N2A95_RS08270	COG0300	oxidoreductase activity
N2A95_RS08275	COG1234	tRNA 3'-trailer cleavage
N2A95_RS08285	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N2A95_RS08290	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
N2A95_RS08310	COG1054	Belongs to the UPF0176 family
N2A95_RS08330	COG0058	SHG alpha-glucan phosphorylase activity
N2A95_RS08335	COG1640	4-alpha-glucanotransferase
N2A95_RS08340	COG1609	Transcriptional regulator
N2A95_RS08350	COG1175	transmembrane transport
N2A95_RS08355	COG3833	ABC-type maltose transport systems, permease component
N2A95_RS08365	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
N2A95_RS08375	COG1696	Membrane protein involved in D-alanine export
N2A95_RS08390	COG0556	nucleotide-excision repair
N2A95_RS08400	COG1126	abc transporter atp-binding protein
N2A95_RS08405	COG0488	(ABC) transporter
N2A95_RS08425	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N2A95_RS08435	COG2309	aminopeptidase activity
N2A95_RS08440	COG0598	Magnesium transport protein CorA
N2A95_RS08445	COG1187	pseudouridine synthase activity
N2A95_RS08455	COG2814	Major facilitator Superfamily
N2A95_RS08465	COG0390	transport system, permease component
N2A95_RS08470	COG4619	ABC transporter
N2A95_RS08490	COG3620	sequence-specific DNA binding
N2A95_RS08495	COG1136	(ABC) transporter
N2A95_RS08505	COG5002	protein histidine kinase activity
N2A95_RS08515	COG0745	RESPONSE REGULATOR receiver
N2A95_RS08535	COG4989	oxidoreductase activity
N2A95_RS08550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N2A95_RS08565	COG1316	TRANSCRIPTIONal
N2A95_RS08575	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N2A95_RS08585	COG0024	Methionine aminopeptidase
N2A95_RS08590	COG4109	DRTGG domain
N2A95_RS08610	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N2A95_RS08625	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N2A95_RS08630	COG1956	GAF domain-containing protein
N2A95_RS08640	COG0572	uridine kinase
N2A95_RS08650	COG0726	polysaccharide deacetylase
N2A95_RS08670	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N2A95_RS08675	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N2A95_RS08680	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N2A95_RS08700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N2A95_RS08705	COG4122	O-methyltransferase activity
N2A95_RS08715	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
N2A95_RS08735	COG4721	ABC-type cobalt transport system, permease component
N2A95_RS08745	COG2223	nitrite transmembrane transporter activity
N2A95_RS08750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N2A95_RS08770	COG1187	pseudouridine synthase activity
N2A95_RS08775	COG0363	glucosamine-6-phosphate deaminase activity
N2A95_RS08800	COG0658	competence protein
N2A95_RS08800	COG2333	competence protein COMEC
N2A95_RS08810	COG0204	Acyl-transferase
N2A95_RS08815	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
N2A95_RS08830	COG0513	Belongs to the DEAD box helicase family
N2A95_RS08835	COG0561	phosphatase activity
N2A95_RS08850	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N2A95_RS08870	COG0768	penicillin binding
N2A95_RS08875	COG2116	formate transmembrane transporter activity
N2A95_RS08895	COG0167	dihydroorotate dehydrogenase activity
N2A95_RS08905	COG2217	Heavy metal translocating P-type atpase
N2A95_RS08920	COG2755	lipolytic protein G-D-S-L family
N2A95_RS08930	COG0497	DNA recombination
N2A95_RS08940	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
N2A95_RS08960	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N2A95_RS08965	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N2A95_RS08985	COG1126	abc transporter atp-binding protein
N2A95_RS08990	COG0765	amino acid transport
N2A95_RS08995	COG4703	Protein of unknown function (DUF1797)
N2A95_RS09000	COG0542	response to heat
N2A95_RS09020	COG3599	regulation of cell shape
N2A95_RS09035	COG1799	cell septum assembly
N2A95_RS09040	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
N2A95_RS09065	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N2A95_RS09075	COG1217	gtp-binding protein TYPA
N2A95_RS09080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N2A95_RS09085	COG1940	carbohydrate kinase activity
N2A95_RS09095	COG0783	Belongs to the Dps family
N2A95_RS09100	COG1132	(ABC) transporter
N2A95_RS09105	COG1132	(ABC) transporter
N2A95_RS09115	COG0820	rRNA (adenine-C2-)-methyltransferase activity
N2A95_RS09125	COG0737	Belongs to the 5'-nucleotidase family
N2A95_RS09130	COG1879	ABC-type sugar transport system periplasmic component
N2A95_RS09135	COG1172	Belongs to the binding-protein-dependent transport system permease family
N2A95_RS09140	COG1129	ABC transporter
N2A95_RS09145	COG1869	D-ribose catabolic process
N2A95_RS09150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N2A95_RS09155	COG1609	Transcriptional regulator
N2A95_RS09160	COG3480	Lon protease (S16) C-terminal proteolytic domain
N2A95_RS09165	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N2A95_RS09170	COG0742	ribosomal rna small subunit methyltransferase
N2A95_RS09175	COG2502	aspartate--ammonia ligase
N2A95_RS09180	COG0549	Belongs to the carbamate kinase family
N2A95_RS09185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N2A95_RS09190	COG1288	antiporter activity
N2A95_RS09195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N2A95_RS09200	COG0454	-acetyltransferase
N2A95_RS09205	COG2235	arginine
N2A95_RS09320	COG0110	maltose O-acetyltransferase activity
N2A95_RS09370	COG2211	Major facilitator Superfamily
N2A95_RS09385	COG1396	sequence-specific DNA binding
N2A95_RS09405	COG1914	H( )-stimulated, divalent metal cation uptake system
N2A95_RS09415	COG1136	(ABC) transporter
N2A95_RS09420	COG0435	Glutathione S-transferase
N2A95_RS09430	COG4152	abc transporter atp-binding protein
N2A95_RS09435	COG1668	transmembrane transport
N2A95_RS09440	COG0586	Pfam SNARE associated Golgi protein
N2A95_RS09450	COG0431	NADPH-dependent FMN reductase
N2A95_RS09450	COG1053	succinate dehydrogenase
N2A95_RS09450	COG3976	FMN-binding domain protein
N2A95_RS09455	COG0710	3-dehydroquinate dehydratase activity
N2A95_RS09465	COG2851	Citrate transporter
N2A95_RS09475	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N2A95_RS09480	COG2271	Major facilitator Superfamily
N2A95_RS09485	COG2271	Major facilitator Superfamily
N2A95_RS09490	COG1028	Short-chain dehydrogenase reductase Sdr
N2A95_RS09525	COG1960	acyl-CoA dehydrogenase activity
N2A95_RS09535	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N2A95_RS09550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N2A95_RS09555	COG1780	Probably involved in ribonucleotide reductase function
N2A95_RS09560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N2A95_RS09580	COG2217	Heavy metal translocating P-type atpase
N2A95_RS09590	COG1573	uracil-dna glycosylase
N2A95_RS09605	COG1309	transcriptional regulator
N2A95_RS09655	COG2137	regulation of response to DNA damage stimulus
N2A95_RS09735	COG1040	competence protein
N2A95_RS09740	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
N2A95_RS09745	COG1739	Uncharacterized protein family UPF0029
N2A95_RS09755	COG1098	S1 RNA binding domain
N2A95_RS09765	COG2197	response regulator
N2A95_RS09770	COG4585	Histidine kinase
N2A95_RS09780	COG2815	serine threonine protein kinase
N2A95_RS09780	COG0515	serine threonine protein kinase
N2A95_RS09790	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N2A95_RS09790	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N2A95_RS09795	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N2A95_RS09800	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N2A95_RS09820	COG1854	S-ribosylhomocysteine lyase activity
N2A95_RS09835	COG0116	Belongs to the methyltransferase superfamily
N2A95_RS09850	COG4474	Belongs to the UPF0398 family
N2A95_RS09855	COG3331	DNA recombination
N2A95_RS09860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N2A95_RS09865	COG3579	cysteine-type endopeptidase activity
N2A95_RS09870	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
N2A95_RS09875	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
N2A95_RS09880	COG1113	amino acid transport
N2A95_RS09885	COG0492	ferredoxin-NADP+ reductase activity
N2A95_RS09895	COG1126	abc transporter atp-binding protein
N2A95_RS09900	COG0765	amino acid transport
N2A95_RS09905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N2A95_RS09910	COG0513	Belongs to the DEAD box helicase family
N2A95_RS09915	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N2A95_RS09920	COG0768	penicillin binding
N2A95_RS09930	COG0275	rRNA processing
N2A95_RS09935	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
N2A95_RS09940	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N2A95_RS09950	COG1131	(ABC) transporter
N2A95_RS09980	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N2A95_RS09990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N2A95_RS10005	COG0751	glycine-tRNA ligase activity
N2A95_RS10010	COG0752	glycyl-tRNA synthetase alpha subunit
N2A95_RS10015	COG1755	Isoprenylcysteine carboxyl methyltransferase
N2A95_RS10020	COG0656	L-ascorbic acid biosynthetic process
N2A95_RS10045	COG0561	phosphatase activity
N2A95_RS10055	COG2217	Heavy metal translocating P-type atpase
N2A95_RS10060	COG3682	Transcriptional regulator
N2A95_RS10080	COG2740	Nucleic-acid-binding protein implicated in transcription termination
N2A95_RS10085	COG0195	Participates in both transcription termination and antitermination
N2A95_RS10110	COG4473	ABC transporter
N2A95_RS10115	COG1131	(ABC) transporter
N2A95_RS10120	COG0537	adenosine 5'-monophosphoramidase activity
N2A95_RS10130	COG1316	TRANSCRIPTIONal
N2A95_RS10140	COG0802	atpase or kinase
N2A95_RS10145	COG2252	PERMEase
N2A95_RS10150	COG0561	phosphatase activity
N2A95_RS10160	COG3715	PTS system
N2A95_RS10165	COG3716	PTS system mannose fructose sorbose family IID component
N2A95_RS10180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
N2A95_RS10200	COG0439	Biotin carboxylase
N2A95_RS10205	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N2A95_RS10215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N2A95_RS10220	COG1028	Short-chain dehydrogenase reductase Sdr
N2A95_RS10225	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
N2A95_RS10240	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N2A95_RS10245	COG1846	Transcriptional regulator
N2A95_RS10250	COG1024	Enoyl-CoA hydratase
N2A95_RS10270	COG1420	regulation of RNA biosynthetic process
N2A95_RS10285	COG0588	phosphoglycerate mutase activity
N2A95_RS10290	COG2848	UPF0210 protein
N2A95_RS10295	COG3830	Belongs to the UPF0237 family
N2A95_RS10315	COG2261	transglycosylase associated protein
N2A95_RS10340	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N2A95_RS10345	COG0574	Belongs to the PEP-utilizing enzyme family
N2A95_RS10345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N2A95_RS10350	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
N2A95_RS10355	COG0517	IMP dehydrogenase activity
N2A95_RS10410	COG3706	GGDEF domain
N2A95_RS10420	COG3655	Transcriptional regulator
N2A95_RS10435	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N2A95_RS10440	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N2A95_RS10540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N2A95_RS10560	COG0201	protein transport
N2A95_RS10565	COG0200	Binds to the 23S rRNA
N2A95_RS10570	COG1841	ribosomal large subunit assembly
N2A95_RS10600	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N2A95_RS10610	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N2A95_RS10625	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N2A95_RS10630	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N2A95_RS10645	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N2A95_RS10650	COG0089	rRNA binding
N2A95_RS10655	COG0088	Forms part of the polypeptide exit tunnel
N2A95_RS10665	COG0051	transcription antitermination factor activity, RNA binding
N2A95_RS10670	COG0534	Mate efflux family protein
N2A95_RS10685	COG1012	belongs to the aldehyde dehydrogenase family
N2A95_RS10685	COG1454	alcohol dehydrogenase
N2A95_RS10700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N2A95_RS10705	COG2255	four-way junction helicase activity
N2A95_RS10720	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N2A95_RS10730	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
N2A95_RS10735	COG0151	Belongs to the GarS family
N2A95_RS10745	COG0138	bifunctional purine biosynthesis protein purh
N2A95_RS10750	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N2A95_RS10755	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N2A95_RS10765	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N2A95_RS10770	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
N2A95_RS10775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N2A95_RS10780	COG0416	fatty acid biosynthetic process
N2A95_RS10785	COG1381	Involved in DNA repair and RecF pathway recombination
N2A95_RS10790	COG0436	Aminotransferase
N2A95_RS10800	COG3942	CHAP domain
N2A95_RS10985	COG0531	amino acid
N2A95_RS10990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N2A95_RS11020	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N2A95_RS11025	COG2244	polysaccharide biosynthetic process
N2A95_RS11030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N2A95_RS11035	COG0193	aminoacyl-tRNA hydrolase activity
N2A95_RS11040	COG0012	GTP binding
N2A95_RS11055	COG0592	DNA-directed DNA polymerase activity
N2A95_RS11060	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N2A95_RS11065	COG4886	Leucine-rich repeat (LRR) protein
N2A95_RS11065	COG4932	domain protein
N2A95_RS11095	COG2184	nucleotidyltransferase activity