locus-tag	class	description
SPB_RS00080	COG0582	viral genome integration into host DNA
SPB_RS00090	COG1028	Short-chain dehydrogenase reductase Sdr
SPB_RS00095	COG0673	inositol 2-dehydrogenase activity
SPB_RS00100	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SPB_RS00115	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPB_RS00165	COG0081	regulation of translation
SPB_RS00180	COG2996	Protein conserved in bacteria
SPB_RS00210	COG1702	phosphate starvation-inducible protein PhoH
SPB_RS00215	COG1573	uracil-dna glycosylase
SPB_RS00220	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SPB_RS00225	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPB_RS00235	COG0494	nUDIX hydrolase
SPB_RS00255	COG1131	(ABC) transporter
SPB_RS00275	COG2364	Membrane
SPB_RS00280	COG0433	COG0433 Predicted ATPase
SPB_RS00285	COG2814	Major facilitator Superfamily
SPB_RS00295	COG0557	exoribonuclease II activity
SPB_RS00300	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SPB_RS00305	COG0346	lactoylglutathione lyase activity
SPB_RS00310	COG0778	Nitroreductase
SPB_RS00315	COG2723	6-phospho-beta-galactosidase activity
SPB_RS00330	COG3711	transcriptional antiterminator
SPB_RS00330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPB_RS00335	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPB_RS00345	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPB_RS00370	COG1609	Transcriptional regulator
SPB_RS00385	COG0438	transferase activity, transferring glycosyl groups
SPB_RS00390	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SPB_RS00395	COG2376	Dihydroxyacetone kinase
SPB_RS00405	COG2376	Dihydroxyacetone kinase
SPB_RS00410	COG1461	Dihydroxyacetone kinase
SPB_RS00415	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SPB_RS00420	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPB_RS00430	COG0765	amino acid transport
SPB_RS00435	COG0765	amino acid transport
SPB_RS00440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPB_RS00450	COG0745	RESPONSE REGULATOR receiver
SPB_RS00455	COG5002	protein histidine kinase activity
SPB_RS00460	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPB_RS00465	COG0571	ribonuclease III activity
SPB_RS00470	COG1196	nuclear chromosome segregation
SPB_RS00475	COG0561	phosphatase activity
SPB_RS00480	COG0561	phosphatase activity
SPB_RS00485	COG0552	protein localization to endoplasmic reticulum
SPB_RS00495	COG2814	Major facilitator Superfamily
SPB_RS00500	COG3689	TIGRFAM TIGR03943 family protein
SPB_RS00505	COG0701	Predicted permease
SPB_RS00515	COG0346	lactoylglutathione lyase activity
SPB_RS00520	COG0745	RESPONSE REGULATOR receiver
SPB_RS00525	COG5002	protein histidine kinase activity
SPB_RS00530	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPB_RS00535	COG0573	inorganic phosphate transmembrane transporter activity
SPB_RS00545	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPB_RS00550	COG0704	Plays a role in the regulation of phosphate uptake
SPB_RS00555	COG2183	response to ionizing radiation
SPB_RS00570	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SPB_RS00600	COG0826	peptidase U32
SPB_RS00610	COG4443	Transcriptional Coactivator p15 (PC4)
SPB_RS00615	COG4166	transmembrane transport
SPB_RS00635	COG1228	amidohydrolase
SPB_RS00640	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SPB_RS00650	COG3404	Formiminotransferase-cyclodeaminase
SPB_RS00665	COG0531	amino acid
SPB_RS00670	COG2986	histidine ammonia-lyase
SPB_RS00700	COG3304	Inner membrane component domain
SPB_RS00710	COG3859	Proton-coupled thiamine transporter YuaJ
SPB_RS00730	COG1164	Oligoendopeptidase f
SPB_RS00740	COG0772	Belongs to the SEDS family
SPB_RS00760	COG2348	transferase activity, transferring amino-acyl groups
SPB_RS00770	COG1078	dGTPase activity
SPB_RS00790	COG0584	glycerophosphoryl diester phosphodiesterase
SPB_RS00805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPB_RS00810	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
SPB_RS00815	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SPB_RS00820	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SPB_RS00825	COG2884	Cell division ATP-binding protein ftsE
SPB_RS00830	COG2177	Part of the ABC transporter FtsEX involved in
SPB_RS00845	COG0436	Aminotransferase
SPB_RS00850	COG0017	Asparaginyl-tRNA synthetase
SPB_RS00860	COG1660	Displays ATPase and GTPase activities
SPB_RS00885	COG2188	Transcriptional regulator
SPB_RS00890	COG2222	sugar isomerase
SPB_RS00895	COG1105	Belongs to the carbohydrate kinase PfkB family
SPB_RS00915	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPB_RS00915	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPB_RS00920	COG3715	PTS system
SPB_RS00925	COG3716	PTS system mannose fructose sorbose family IID component
SPB_RS00945	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPB_RS00950	COG2153	protein acetylation
SPB_RS00955	COG0625	glutathione transferase activity
SPB_RS00965	COG0716	FMN binding
SPB_RS00970	COG0077	Prephenate dehydratase
SPB_RS00970	COG1605	Chorismate mutase
SPB_RS00975	COG0038	chloride channel
SPB_RS00980	COG0335	large ribosomal subunit rRNA binding
SPB_RS00985	COG0352	thiamine-phosphate diphosphorylase activity
SPB_RS00995	COG0772	Belongs to the SEDS family
SPB_RS01010	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SPB_RS01015	COG0560	Phosphoserine phosphatase
SPB_RS01035	COG0148	phosphopyruvate hydratase activity
SPB_RS01050	COG2031	fatty acid transporter
SPB_RS01065	COG0183	Belongs to the thiolase family
SPB_RS01090	COG1269	ATP hydrolysis coupled proton transport
SPB_RS01095	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPB_RS01110	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
SPB_RS01130	COG0778	Nitroreductase
SPB_RS01140	COG4708	membrane
SPB_RS01145	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SPB_RS01150	COG1597	lipid kinase activity
SPB_RS01155	COG1523	belongs to the glycosyl hydrolase 13 family
SPB_RS01160	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SPB_RS01165	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SPB_RS01175	COG0297	glycogen (starch) synthase activity
SPB_RS01180	COG0058	SHG alpha-glucan phosphorylase activity
SPB_RS01200	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPB_RS01210	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SPB_RS01215	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SPB_RS01220	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SPB_RS01230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPB_RS01255	COG0072	phenylalanine-tRNA ligase activity
SPB_RS01255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPB_RS01270	COG0577	efflux transmembrane transporter activity
SPB_RS01280	COG2321	neutral zinc metallopeptidase
SPB_RS01285	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SPB_RS01290	COG1074	ATP-dependent DNA helicase activity
SPB_RS01295	COG0436	Aminotransferase
SPB_RS01300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPB_RS01310	COG1970	mechanosensitive ion channel activity
SPB_RS01315	COG0358	DNA primase activity
SPB_RS01320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPB_RS01325	COG2151	metal-sulfur cluster biosynthetic enzyme
SPB_RS01340	COG1442	glycosyl transferase family 8
SPB_RS01340	COG1216	Glycosyl transferase, family 2
SPB_RS01355	COG1216	Glycosyl transferase, family 2
SPB_RS01355	COG1442	glycosyl transferase family 8
SPB_RS01360	COG3754	Rhamnan synthesis protein F
SPB_RS01365	COG1368	sulfuric ester hydrolase activity
SPB_RS01375	COG0463	Glycosyl transferase, family 2
SPB_RS01380	COG2246	polysaccharide biosynthetic process
SPB_RS01420	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SPB_RS01425	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SPB_RS01430	COG1368	sulfuric ester hydrolase activity
SPB_RS01435	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPB_RS01455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPB_RS01460	COG0285	dihydrofolate synthase activity
SPB_RS01470	COG1104	cysteine desulfurase activity
SPB_RS01475	COG0301	tRNA thio-modification
SPB_RS01495	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SPB_RS01500	COG0583	DNA-binding transcription factor activity
SPB_RS01510	COG0564	pseudouridine synthase activity
SPB_RS01515	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SPB_RS01540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPB_RS01545	COG1136	(ABC) transporter
SPB_RS01550	COG0577	efflux transmembrane transporter activity
SPB_RS01560	COG0228	four-way junction DNA binding
SPB_RS01565	COG1837	Belongs to the UPF0109 family
SPB_RS01575	COG1442	glycosyl transferase family 8
SPB_RS01585	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SPB_RS01590	COG0336	Belongs to the RNA methyltransferase TrmD family
SPB_RS01610	COG1349	DNA-binding transcription factor activity
SPB_RS01615	COG1105	Belongs to the carbohydrate kinase PfkB family
SPB_RS01620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPB_RS01620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPB_RS01620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPB_RS01625	COG3942	CHAP domain
SPB_RS01625	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPB_RS01630	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPB_RS01630	COG1388	LysM domain
SPB_RS01650	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SPB_RS01660	COG0488	(ABC) transporter
SPB_RS01675	COG1132	(ABC) transporter
SPB_RS01680	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPB_RS01685	COG0242	peptide deformylase activity
SPB_RS01695	COG0737	Belongs to the 5'-nucleotidase family
SPB_RS01700	COG1132	(ABC) transporter
SPB_RS01705	COG1132	(ABC) transporter
SPB_RS01735	COG3425	synthase
SPB_RS01745	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPB_RS01750	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SPB_RS01770	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SPB_RS01775	COG0222	ribosome binding
SPB_RS01825	COG3942	CHAP domain
SPB_RS01825	COG1388	LysM domain
SPB_RS01885	COG3843	relaxase mobilization nuclease domain protein
SPB_RS01955	COG2261	transglycosylase associated protein
SPB_RS01990	COG0783	Belongs to the Dps family
SPB_RS01995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPB_RS02005	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SPB_RS02010	COG2217	Heavy metal translocating P-type atpase
SPB_RS02060	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SPB_RS02065	COG1737	Transcriptional regulator
SPB_RS02070	COG1105	Belongs to the carbohydrate kinase PfkB family
SPB_RS02075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPB_RS02075	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPB_RS02075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPB_RS02080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPB_RS02115	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPB_RS02115	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPB_RS02130	COG1396	sequence-specific DNA binding
SPB_RS02140	COG4974	Belongs to the 'phage' integrase family
SPB_RS02150	COG0463	Glycosyl transferase, family 2
SPB_RS02160	COG1486	melibiose metabolic process
SPB_RS02165	COG1737	Transcriptional regulator
SPB_RS02170	COG0446	pyridine nucleotide-disulphide oxidoreductase
SPB_RS02175	COG0366	Alpha amylase catalytic
SPB_RS02180	COG0726	polysaccharide deacetylase
SPB_RS02185	COG0460	homoserine dehydrogenase
SPB_RS02190	COG0083	homoserine kinase activity
SPB_RS02195	COG0285	dihydrofolate synthase activity
SPB_RS02220	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SPB_RS02230	COG1176	ABC-type spermidine putrescine transport system, permease component I
SPB_RS02235	COG1177	transmembrane transport
SPB_RS02245	COG4565	transcriptional regulatory protein
SPB_RS02250	COG3290	protein histidine kinase activity
SPB_RS02255	COG3493	citrate carrier protein
SPB_RS02265	COG0038	chloride channel
SPB_RS02270	COG3711	transcriptional antiterminator
SPB_RS02275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPB_RS02275	COG2190	(PTS) system
SPB_RS02275	COG1263	PTS System
SPB_RS02280	COG2272	Belongs to the type-B carboxylesterase lipase family
SPB_RS02285	COG2207	Transcriptional regulator
SPB_RS02290	COG2723	6-phospho-beta-galactosidase activity
SPB_RS02300	COG0561	phosphatase activity
SPB_RS02305	COG2723	6-phospho-beta-galactosidase activity
SPB_RS02315	COG0406	alpha-ribazole phosphatase activity
SPB_RS02325	COG2723	6-phospho-beta-galactosidase activity
SPB_RS02330	COG0628	permease
SPB_RS02335	COG2003	Belongs to the UPF0758 family
SPB_RS02340	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPB_RS02360	COG1104	cysteine desulfurase activity
SPB_RS02375	COG2357	RelA SpoT domain protein
SPB_RS02385	COG0564	pseudouridine synthase activity
SPB_RS02390	COG0280	phosphate acetyltransferase
SPB_RS02395	COG4221	oxidoreductase activity
SPB_RS02400	COG0477	Major facilitator Superfamily
SPB_RS02430	COG1174	glycine betaine transport
SPB_RS02435	COG2723	6-phospho-beta-galactosidase activity
SPB_RS02440	COG0516	GMP reductase activity
SPB_RS02445	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPB_RS02450	COG2233	PERMEase
SPB_RS02475	COG2890	protein-(glutamine-N5) methyltransferase activity
SPB_RS02480	COG0009	L-threonylcarbamoyladenylate synthase
SPB_RS02490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SPB_RS02510	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPB_RS02515	COG0039	L-malate dehydrogenase activity
SPB_RS02525	COG3764	Sortase (surface protein transpeptidase)
SPB_RS02530	COG0346	lactoylglutathione lyase activity
SPB_RS02540	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPB_RS02550	COG1811	Na channel or pump
SPB_RS02560	COG0386	Belongs to the glutathione peroxidase family
SPB_RS02570	COG2188	Transcriptional regulator
SPB_RS02580	COG2723	6-phospho-beta-galactosidase activity
SPB_RS02585	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPB_RS02600	COG3104	oligopeptide transport
SPB_RS02620	COG2188	Transcriptional regulator
SPB_RS02630	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPB_RS02660	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPB_RS02670	COG0673	inositol 2-dehydrogenase activity
SPB_RS02685	COG0561	phosphatase activity
SPB_RS02705	COG2723	6-phospho-beta-galactosidase activity
SPB_RS02710	COG0604	alcohol dehydrogenase
SPB_RS02715	COG0662	Cupin 2, conserved barrel domain protein
SPB_RS02720	COG1053	succinate dehydrogenase
SPB_RS02720	COG3976	FMN-binding domain protein
SPB_RS02720	COG0431	NADPH-dependent FMN reductase
SPB_RS02760	COG4974	Belongs to the 'phage' integrase family
SPB_RS02765	COG1902	pentaerythritol trinitrate reductase activity
SPB_RS02780	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SPB_RS02785	COG0642	Histidine kinase
SPB_RS02800	COG1136	(ABC) transporter
SPB_RS02810	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SPB_RS02835	COG0583	DNA-binding transcription factor activity
SPB_RS02840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPB_RS02845	COG0758	DNA mediated transformation
SPB_RS02850	COG0110	maltose O-acetyltransferase activity
SPB_RS02855	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SPB_RS02860	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPB_RS02870	COG0095	Lipoate-protein ligase
SPB_RS02875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPB_RS02890	COG1272	protein, Hemolysin III
SPB_RS02910	COG0488	(ABC) transporter
SPB_RS02915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPB_RS02920	COG1328	CTP reductase activity
SPB_RS02920	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPB_RS02925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPB_RS02930	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPB_RS02935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPB_RS02945	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SPB_RS02955	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPB_RS02960	COG4684	Psort location CytoplasmicMembrane, score
SPB_RS02965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPB_RS02970	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPB_RS02975	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPB_RS02980	COG3845	ABC transporter
SPB_RS02985	COG1744	ABC transporter substrate-binding protein PnrA-like
SPB_RS02990	COG0295	cytidine deaminase activity
SPB_RS02995	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SPB_RS03000	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SPB_RS03005	COG2813	Specifically methylates the guanine in position
SPB_RS03020	COG5002	protein histidine kinase activity
SPB_RS03025	COG0745	RESPONSE REGULATOR receiver
SPB_RS03035	COG0704	Plays a role in the regulation of phosphate uptake
SPB_RS03050	COG0581	inorganic phosphate transmembrane transporter activity
SPB_RS03055	COG0573	inorganic phosphate transmembrane transporter activity
SPB_RS03065	COG0483	inositol monophosphate 1-phosphatase activity
SPB_RS03070	COG4476	Belongs to the UPF0223 family
SPB_RS03080	COG0196	riboflavin kinase activity
SPB_RS03155	COG2261	transglycosylase associated protein
SPB_RS03170	COG1115	amino acid carrier protein
SPB_RS03175	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPB_RS03180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPB_RS03185	COG1126	abc transporter atp-binding protein
SPB_RS03190	COG0765	amino acid transport
SPB_RS03195	COG2824	Alkylphosphonate utilization operon protein PhnA
SPB_RS03200	COG0246	Mannitol dehydrogenase
SPB_RS03205	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPB_RS03210	COG3711	transcriptional antiterminator
SPB_RS03215	COG2213	PTS system mannitol-specific
SPB_RS03230	COG0469	pyruvate kinase activity
SPB_RS03235	COG0205	6-phosphofructokinase activity
SPB_RS03245	COG1725	Transcriptional regulator
SPB_RS03250	COG1131	(ABC) transporter
SPB_RS03420	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
SPB_RS03455	COG0556	nucleotide-excision repair
SPB_RS03525	COG0539	negative regulation of cytoplasmic translation
SPB_RS03545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPB_RS03555	COG0187	DNA topoisomerase II activity
SPB_RS03570	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SPB_RS03575	COG0765	amino acid transport
SPB_RS03580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPB_RS03590	COG1881	PFAM PEBP family protein
SPB_RS03635	COG0438	transferase activity, transferring glycosyl groups
SPB_RS03640	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SPB_RS03640	COG0463	Glycosyl transferase, family 2
SPB_RS03645	COG0438	transferase activity, transferring glycosyl groups
SPB_RS03655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPB_RS03660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SPB_RS03690	COG1316	TRANSCRIPTIONal
SPB_RS03725	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SPB_RS03735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPB_RS03745	COG0322	excinuclease ABC activity
SPB_RS03755	COG0561	phosphatase activity
SPB_RS03760	COG1012	belongs to the aldehyde dehydrogenase family
SPB_RS03765	COG1011	Hydrolase
SPB_RS03775	COG2259	Doxx family
SPB_RS03800	COG0667	Aldo Keto reductase
SPB_RS03805	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SPB_RS03815	COG0789	Transcriptional regulator
SPB_RS03820	COG1063	alcohol dehydrogenase
SPB_RS03825	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SPB_RS03835	COG1028	Short-chain dehydrogenase reductase Sdr
SPB_RS03840	COG0656	L-ascorbic acid biosynthetic process
SPB_RS03855	COG1418	mRNA catabolic process
SPB_RS03870	COG0481	GTPase activity
SPB_RS03890	COG0647	UMP catabolic process
SPB_RS03900	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPB_RS03910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPB_RS03925	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPB_RS03930	COG3442	glutamine amidotransferase
SPB_RS03935	COG0095	Lipoate-protein ligase
SPB_RS03945	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPB_RS03950	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPB_RS03950	COG0022	dehydrogenase e1 component
SPB_RS03955	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPB_RS03960	COG0488	(ABC) transporter
SPB_RS03980	COG3842	ATPase activity
SPB_RS03995	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPB_RS04000	COG3527	Alpha-acetolactate decarboxylase
SPB_RS04005	COG0028	Belongs to the TPP enzyme family
SPB_RS04010	COG0457	Tetratricopeptide repeat
SPB_RS04015	COG0628	permease
SPB_RS04020	COG1051	belongs to the nudix hydrolase family
SPB_RS04025	COG2706	6-phosphogluconolactonase activity
SPB_RS04035	COG1088	dTDP-glucose 4,6-dehydratase activity
SPB_RS04045	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SPB_RS04050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPB_RS04065	COG2384	SAM-dependent methyltransferase
SPB_RS04075	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPB_RS04085	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPB_RS04090	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPB_RS04090	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPB_RS04095	COG0300	oxidoreductase activity
SPB_RS04100	COG1234	tRNA 3'-trailer cleavage
SPB_RS04110	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPB_RS04115	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SPB_RS04130	COG1054	Belongs to the UPF0176 family
SPB_RS04150	COG0058	SHG alpha-glucan phosphorylase activity
SPB_RS04155	COG1640	4-alpha-glucanotransferase
SPB_RS04160	COG1609	Transcriptional regulator
SPB_RS04170	COG1175	transmembrane transport
SPB_RS04175	COG3833	ABC-type maltose transport systems, permease component
SPB_RS04185	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPB_RS04195	COG1696	Membrane protein involved in D-alanine export
SPB_RS04210	COG0556	nucleotide-excision repair
SPB_RS04220	COG1126	abc transporter atp-binding protein
SPB_RS04230	COG0488	(ABC) transporter
SPB_RS04245	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SPB_RS04250	COG2309	aminopeptidase activity
SPB_RS04255	COG0598	Magnesium transport protein CorA
SPB_RS04260	COG1187	pseudouridine synthase activity
SPB_RS04270	COG2814	Major facilitator Superfamily
SPB_RS04280	COG0390	transport system, permease component
SPB_RS04285	COG4619	ABC transporter
SPB_RS04305	COG3620	sequence-specific DNA binding
SPB_RS04310	COG1136	(ABC) transporter
SPB_RS04320	COG5002	protein histidine kinase activity
SPB_RS04325	COG0745	RESPONSE REGULATOR receiver
SPB_RS04340	COG4989	oxidoreductase activity
SPB_RS04355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPB_RS04380	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SPB_RS04390	COG0024	Methionine aminopeptidase
SPB_RS04395	COG4109	DRTGG domain
SPB_RS04415	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SPB_RS04430	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPB_RS04435	COG1956	GAF domain-containing protein
SPB_RS04445	COG0572	uridine kinase
SPB_RS04455	COG0726	polysaccharide deacetylase
SPB_RS04475	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPB_RS04480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPB_RS04485	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPB_RS04505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SPB_RS04510	COG4122	O-methyltransferase activity
SPB_RS04515	COG0352	thiamine-phosphate diphosphorylase activity
SPB_RS04525	COG4721	ABC-type cobalt transport system, permease component
SPB_RS04535	COG2223	nitrite transmembrane transporter activity
SPB_RS04540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPB_RS04560	COG1187	pseudouridine synthase activity
SPB_RS04565	COG0363	glucosamine-6-phosphate deaminase activity
SPB_RS04590	COG0658	competence protein
SPB_RS04590	COG2333	competence protein COMEC
SPB_RS04600	COG0204	Acyl-transferase
SPB_RS04605	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPB_RS04620	COG0513	Belongs to the DEAD box helicase family
SPB_RS04625	COG0561	phosphatase activity
SPB_RS04640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPB_RS04660	COG0768	penicillin binding
SPB_RS04665	COG2116	formate transmembrane transporter activity
SPB_RS04685	COG0167	dihydroorotate dehydrogenase activity
SPB_RS04695	COG2217	Heavy metal translocating P-type atpase
SPB_RS04710	COG2755	lipolytic protein G-D-S-L family
SPB_RS04720	COG0497	DNA recombination
SPB_RS04730	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPB_RS04750	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SPB_RS04755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPB_RS04770	COG1126	abc transporter atp-binding protein
SPB_RS04775	COG0765	amino acid transport
SPB_RS04780	COG4703	Protein of unknown function (DUF1797)
SPB_RS04785	COG0542	response to heat
SPB_RS04805	COG3599	regulation of cell shape
SPB_RS04820	COG1799	cell septum assembly
SPB_RS04825	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPB_RS04850	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SPB_RS04860	COG1217	gtp-binding protein TYPA
SPB_RS04865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPB_RS04870	COG1940	carbohydrate kinase activity
SPB_RS04880	COG0783	Belongs to the Dps family
SPB_RS04885	COG1132	(ABC) transporter
SPB_RS04890	COG1132	(ABC) transporter
SPB_RS04900	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SPB_RS04905	COG4470	Protein conserved in bacteria
SPB_RS04910	COG0737	Belongs to the 5'-nucleotidase family
SPB_RS04915	COG1879	ABC-type sugar transport system periplasmic component
SPB_RS04920	COG1172	Belongs to the binding-protein-dependent transport system permease family
SPB_RS04925	COG1129	ABC transporter
SPB_RS04930	COG1869	D-ribose catabolic process
SPB_RS04935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPB_RS04940	COG1609	Transcriptional regulator
SPB_RS04945	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPB_RS04950	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SPB_RS04955	COG0742	ribosomal rna small subunit methyltransferase
SPB_RS04960	COG2502	aspartate--ammonia ligase
SPB_RS04965	COG0549	Belongs to the carbamate kinase family
SPB_RS04970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPB_RS04975	COG1288	antiporter activity
SPB_RS04980	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SPB_RS04985	COG0454	-acetyltransferase
SPB_RS04990	COG2235	arginine
SPB_RS05080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPB_RS05085	COG0110	maltose O-acetyltransferase activity
SPB_RS05125	COG0582	viral genome integration into host DNA
SPB_RS05150	COG1307	EDD domain protein, DegV family
SPB_RS05185	COG1131	(ABC) transporter
SPB_RS05255	COG1136	(ABC) transporter
SPB_RS05260	COG0435	Glutathione S-transferase
SPB_RS05270	COG4152	abc transporter atp-binding protein
SPB_RS05275	COG1668	transmembrane transport
SPB_RS05280	COG0586	Pfam SNARE associated Golgi protein
SPB_RS05290	COG1053	succinate dehydrogenase
SPB_RS05290	COG0431	NADPH-dependent FMN reductase
SPB_RS05290	COG3976	FMN-binding domain protein
SPB_RS05295	COG0710	3-dehydroquinate dehydratase activity
SPB_RS05300	COG2851	Citrate transporter
SPB_RS05310	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPB_RS05315	COG2271	Major facilitator Superfamily
SPB_RS05320	COG2271	Major facilitator Superfamily
SPB_RS05325	COG1028	Short-chain dehydrogenase reductase Sdr
SPB_RS05335	COG0583	DNA-binding transcription factor activity
SPB_RS05375	COG2137	regulation of response to DNA damage stimulus
SPB_RS05450	COG1040	competence protein
SPB_RS05455	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPB_RS05460	COG1739	Uncharacterized protein family UPF0029
SPB_RS05470	COG1098	S1 RNA binding domain
SPB_RS05480	COG2197	response regulator
SPB_RS05485	COG4585	Histidine kinase
SPB_RS05495	COG2815	serine threonine protein kinase
SPB_RS05495	COG0515	serine threonine protein kinase
SPB_RS05505	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPB_RS05505	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPB_RS05510	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SPB_RS05515	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPB_RS05540	COG1854	S-ribosylhomocysteine lyase activity
SPB_RS05565	COG0116	Belongs to the methyltransferase superfamily
SPB_RS05575	COG4474	Belongs to the UPF0398 family
SPB_RS05580	COG3331	DNA recombination
SPB_RS05585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPB_RS05590	COG2801	Transposase and inactivated derivatives
SPB_RS05600	COG3579	cysteine-type endopeptidase activity
SPB_RS05605	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SPB_RS05610	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPB_RS05615	COG1113	amino acid transport
SPB_RS05620	COG0492	ferredoxin-NADP+ reductase activity
SPB_RS05630	COG1126	abc transporter atp-binding protein
SPB_RS05635	COG0765	amino acid transport
SPB_RS05640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPB_RS05645	COG0513	Belongs to the DEAD box helicase family
SPB_RS05650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPB_RS05655	COG0768	penicillin binding
SPB_RS05665	COG0275	rRNA processing
SPB_RS05670	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SPB_RS05675	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SPB_RS05685	COG1131	(ABC) transporter
SPB_RS05715	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPB_RS05725	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SPB_RS05740	COG0751	glycine-tRNA ligase activity
SPB_RS05745	COG0752	glycyl-tRNA synthetase alpha subunit
SPB_RS05755	COG0656	L-ascorbic acid biosynthetic process
SPB_RS05780	COG0561	phosphatase activity
SPB_RS05790	COG2217	Heavy metal translocating P-type atpase
SPB_RS05795	COG3682	Transcriptional regulator
SPB_RS05815	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPB_RS05820	COG0195	Participates in both transcription termination and antitermination
SPB_RS05845	COG4473	ABC transporter
SPB_RS05850	COG1131	(ABC) transporter
SPB_RS05855	COG0537	adenosine 5'-monophosphoramidase activity
SPB_RS05865	COG1316	TRANSCRIPTIONal
SPB_RS05875	COG0802	atpase or kinase
SPB_RS05880	COG2252	PERMEase
SPB_RS05885	COG0561	phosphatase activity
SPB_RS05895	COG3715	PTS system
SPB_RS05900	COG3716	PTS system mannose fructose sorbose family IID component
SPB_RS05915	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SPB_RS05935	COG0439	Biotin carboxylase
SPB_RS05940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SPB_RS05950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPB_RS05955	COG1028	Short-chain dehydrogenase reductase Sdr
SPB_RS05960	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPB_RS05975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPB_RS05980	COG1846	Transcriptional regulator
SPB_RS05985	COG1024	Enoyl-CoA hydratase
SPB_RS06005	COG1420	regulation of RNA biosynthetic process
SPB_RS06020	COG0588	phosphoglycerate mutase activity
SPB_RS06025	COG2848	UPF0210 protein
SPB_RS06030	COG3830	Belongs to the UPF0237 family
SPB_RS06050	COG2261	transglycosylase associated protein
SPB_RS06075	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SPB_RS06080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPB_RS06080	COG0574	Belongs to the PEP-utilizing enzyme family
SPB_RS06085	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SPB_RS06090	COG0517	IMP dehydrogenase activity
SPB_RS06105	COG0446	pyridine nucleotide-disulphide oxidoreductase
SPB_RS06110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPB_RS06115	COG1937	Protein conserved in bacteria
SPB_RS06120	COG1335	isochorismatase
SPB_RS06125	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SPB_RS06130	COG0436	Aminotransferase
SPB_RS06135	COG0589	response to stress
SPB_RS06140	COG0561	phosphatase activity
SPB_RS06145	COG0252	asparaginase activity
SPB_RS06150	COG4989	oxidoreductase activity
SPB_RS06155	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPB_RS06160	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SPB_RS06165	COG0736	holo-[acyl-carrier-protein] synthase activity
SPB_RS06170	COG0653	protein targeting
SPB_RS06175	COG1482	cell wall glycoprotein biosynthetic process
SPB_RS06180	COG2723	6-phospho-beta-galactosidase activity
SPB_RS06185	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPB_RS06195	COG1940	carbohydrate kinase activity
SPB_RS06200	COG1263	PTS System
SPB_RS06200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPB_RS06200	COG2190	(PTS) system
SPB_RS06205	COG1621	beta-fructofuranosidase activity
SPB_RS06210	COG1609	Transcriptional regulator
SPB_RS06215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPB_RS06230	COG2131	deaminase
SPB_RS06235	COG0006	proline dipeptidase activity
SPB_RS06270	COG1194	a g-specific adenine glycosylase
SPB_RS06280	COG3118	belongs to the thioredoxin family
SPB_RS06285	COG1193	negative regulation of DNA recombination
SPB_RS06300	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SPB_RS06305	COG0681	Belongs to the peptidase S26 family
SPB_RS06310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPB_RS06325	COG1882	Formate acetyltransferase
SPB_RS06330	COG2153	protein acetylation
SPB_RS06335	COG0366	Alpha amylase catalytic
SPB_RS06340	COG3833	ABC-type maltose transport systems, permease component
SPB_RS06345	COG1175	transmembrane transport
SPB_RS06350	COG2182	Extracellular solute-binding protein
SPB_RS06365	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPB_RS06385	COG2936	dipeptidyl-peptidase activity
SPB_RS06405	COG1940	carbohydrate kinase activity
SPB_RS06420	COG0395	ABC-type sugar transport system, permease component
SPB_RS06425	COG4209	transmembrane transport
SPB_RS06430	COG1609	Transcriptional regulator
SPB_RS06440	COG3942	CHAP domain
SPB_RS06440	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPB_RS06460	COG1695	Transcriptional regulator
SPB_RS06465	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SPB_RS06490	COG3052	prosthetic group binding
SPB_RS06500	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SPB_RS06505	COG0511	ligase activity, forming carbon-carbon bonds
SPB_RS06515	COG2851	Citrate transporter
SPB_RS06525	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
SPB_RS06530	COG3180	Ammonia monooxygenase
SPB_RS06535	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SPB_RS06540	COG0583	DNA-binding transcription factor activity
SPB_RS06545	COG2851	Citrate transporter
SPB_RS06550	COG2828	Protein conserved in bacteria
SPB_RS06570	COG3655	Transcriptional regulator
SPB_RS06580	COG2723	6-phospho-beta-galactosidase activity
SPB_RS06585	COG2814	Major facilitator Superfamily
SPB_RS06595	COG0673	inositol 2-dehydrogenase activity
SPB_RS06600	COG2348	transferase activity, transferring amino-acyl groups
SPB_RS06610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPB_RS06620	COG1028	Short-chain dehydrogenase reductase Sdr
SPB_RS06630	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
SPB_RS06635	COG1609	Transcriptional regulator
SPB_RS06640	COG2723	6-phospho-beta-galactosidase activity
SPB_RS06645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPB_RS06645	COG1263	PTS System
SPB_RS06645	COG2190	(PTS) system
SPB_RS06650	COG3711	transcriptional antiterminator
SPB_RS06665	COG1621	beta-fructofuranosidase activity
SPB_RS06670	COG2207	Transcriptional regulator
SPB_RS06705	COG2176	DNA-directed DNA polymerase activity
SPB_RS06715	COG2081	HI0933 family
SPB_RS06735	COG1214	PFAM Peptidase M22, glycoprotease
SPB_RS06740	COG5503	Protein of unknown function (DUF1447)
SPB_RS06750	COG4608	Belongs to the ABC transporter superfamily
SPB_RS06755	COG0444	Belongs to the ABC transporter superfamily
SPB_RS06760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPB_RS06765	COG0601	transmembrane transport
SPB_RS06770	COG4166	transmembrane transport
SPB_RS06775	COG0174	glutamine synthetase
SPB_RS06780	COG0789	Transcriptional regulator
SPB_RS06790	COG0126	phosphoglycerate kinase activity
SPB_RS06795	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SPB_RS06800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SPB_RS06810	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SPB_RS06820	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPB_RS06855	COG2814	Major facilitator Superfamily
SPB_RS06865	COG2226	methyltransferase
SPB_RS06880	COG0084	hydrolase, TatD family'
SPB_RS06885	COG0582	viral genome integration into host DNA
SPB_RS06935	COG3711	transcriptional antiterminator
SPB_RS06935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPB_RS06940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPB_RS06940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPB_RS06940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPB_RS06955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPB_RS06965	COG1653	transport
SPB_RS06970	COG0395	ABC-type sugar transport system, permease component
SPB_RS06980	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SPB_RS07005	COG1131	(ABC) transporter
SPB_RS07015	COG1847	R3H domain protein
SPB_RS07025	COG0594	ribonuclease P activity
SPB_RS07030	COG0165	Argininosuccinate lyase
SPB_RS07055	COG3290	protein histidine kinase activity
SPB_RS07085	COG0756	dUTP diphosphatase activity
SPB_RS07090	COG0582	viral genome integration into host DNA
SPB_RS07185	COG1114	Component of the transport system for branched-chain amino acids
SPB_RS07215	COG0640	Transcriptional regulator
SPB_RS07220	COG0708	Exodeoxyribonuclease III
SPB_RS07230	COG0346	lactoylglutathione lyase activity
SPB_RS07240	COG1393	Belongs to the ArsC family
SPB_RS07245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SPB_RS07250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SPB_RS07260	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SPB_RS07285	COG1774	PSP1 C-terminal conserved region
SPB_RS07290	COG0470	DNA polymerase III
SPB_RS07300	COG0517	IMP dehydrogenase activity
SPB_RS07340	COG0740	serine-type endopeptidase activity
SPB_RS07350	COG2244	polysaccharide biosynthetic process
SPB_RS07360	COG1120	ATPase activity
SPB_RS07365	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPB_RS07370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPB_RS07375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPB_RS07390	COG1227	inorganic diphosphatase activity
SPB_RS07395	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPB_RS07400	COG1253	flavin adenine dinucleotide binding
SPB_RS07405	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPB_RS07415	COG1131	(ABC) transporter
SPB_RS07420	COG1242	4 iron, 4 sulfur cluster binding
SPB_RS07425	COG0671	phosphoesterase, PA-phosphatase related
SPB_RS07430	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPB_RS07440	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SPB_RS07445	COG1187	pseudouridine synthase activity
SPB_RS07455	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SPB_RS07480	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SPB_RS07505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPB_RS07510	COG1254	Belongs to the acylphosphatase family
SPB_RS07525	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPB_RS07545	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPB_RS07555	COG1484	DNA-dependent DNA replication
SPB_RS07565	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPB_RS07575	COG0745	RESPONSE REGULATOR receiver
SPB_RS07585	COG0501	Belongs to the peptidase M48B family
SPB_RS07590	COG1704	LemA family
SPB_RS07595	COG0357	Ribosomal RNA small subunit methyltransferase G
SPB_RS07600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPB_RS07605	COG0569	domain protein
SPB_RS07625	COG1464	Belongs to the NlpA lipoprotein family
SPB_RS07630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPB_RS07635	COG0217	transcriptional regulatory protein
SPB_RS07645	COG0789	Transcriptional regulator
SPB_RS07650	COG1323	Belongs to the UPF0348 family
SPB_RS07660	COG2226	methyltransferase
SPB_RS07665	COG0799	negative regulation of ribosome biogenesis
SPB_RS07670	COG1335	isochorismatase
SPB_RS07675	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPB_RS07685	COG1534	Rna-binding protein
SPB_RS07690	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPB_RS07695	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SPB_RS07740	COG0444	Belongs to the ABC transporter superfamily
SPB_RS07745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPB_RS07750	COG0601	transmembrane transport
SPB_RS07755	COG4166	transmembrane transport
SPB_RS07760	COG1686	Belongs to the peptidase S11 family
SPB_RS07770	COG1686	Belongs to the peptidase S11 family
SPB_RS07775	COG0719	Fe-S assembly protein
SPB_RS07785	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPB_RS07790	COG0719	Fe-S assembly protein
SPB_RS07800	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPB_RS07820	COG0765	amino acid transport
SPB_RS07825	COG1126	abc transporter atp-binding protein
SPB_RS07870	COG1346	cytolysis
SPB_RS07880	COG3279	Response regulator of the LytR AlgR family
SPB_RS07885	COG3275	phosphorelay sensor kinase activity
SPB_RS07895	COG3343	RNA polymerase activity
SPB_RS07900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPB_RS07905	COG0544	peptidyl-prolyl cis-trans isomerase activity
SPB_RS07910	COG0668	transmembrane transport
SPB_RS07920	COG4720	Psort location CytoplasmicMembrane, score
SPB_RS07925	COG0352	thiamine-phosphate diphosphorylase activity
SPB_RS07925	COG0351	phosphomethylpyrimidine kinase
SPB_RS07930	COG0101	tRNA pseudouridine synthase activity
SPB_RS07935	COG0527	aspartate kinase activity
SPB_RS07975	COG4720	Psort location CytoplasmicMembrane, score
SPB_RS07980	COG1122	ATPase activity
SPB_RS08000	COG1511	domain protein
SPB_RS08015	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPB_RS08035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPB_RS08050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPB_RS08080	COG1733	regulation of RNA biosynthetic process
SPB_RS08120	COG2801	Transposase and inactivated derivatives
SPB_RS08155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPB_RS08205	COG1674	ftsk spoiiie
SPB_RS08240	COG0433	COG0433 Predicted ATPase
SPB_RS08255	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPB_RS08255	COG3942	CHAP domain
SPB_RS08275	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPB_RS08295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPB_RS08305	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPB_RS08315	COG1045	serine acetyltransferase
SPB_RS08330	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SPB_RS08340	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SPB_RS08340	COG0248	Ppx GppA phosphatase
SPB_RS08345	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SPB_RS08355	COG0242	peptide deformylase activity
SPB_RS08395	COG4589	Belongs to the CDS family
SPB_RS08405	COG1862	Preprotein translocase
SPB_RS08415	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPB_RS08420	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPB_RS08425	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPB_RS08430	COG1609	Transcriptional regulator
SPB_RS08435	COG0110	maltose O-acetyltransferase activity
SPB_RS08445	COG3842	ATPase activity
SPB_RS08455	COG0366	Alpha amylase catalytic
SPB_RS08460	COG0395	ABC-type sugar transport system, permease component
SPB_RS08465	COG1175	transmembrane transport
SPB_RS08470	COG1653	transport
SPB_RS08480	COG2207	Transcriptional regulator
SPB_RS08485	COG1490	D-aminoacyl-tRNA deacylase activity
SPB_RS08500	COG1363	Peptidase, m42
SPB_RS08515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPB_RS08515	COG1263	PTS System
SPB_RS08515	COG2190	(PTS) system
SPB_RS08520	COG1609	Transcriptional regulator
SPB_RS08535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPB_RS08540	COG2264	protein methyltransferase activity
SPB_RS08560	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPB_RS08610	COG2946	Replication initiation factor
SPB_RS08645	COG3716	PTS system mannose fructose sorbose family IID component
SPB_RS08670	COG2197	response regulator
SPB_RS08675	COG4585	Histidine kinase
SPB_RS08685	COG0561	phosphatase activity
SPB_RS08710	COG3655	Transcriptional regulator
SPB_RS08725	COG2217	Heavy metal translocating P-type atpase
SPB_RS08730	COG0789	Transcriptional regulator
SPB_RS08730	COG4978	Transcriptional regulator
SPB_RS08745	COG2094	Belongs to the DNA glycosylase MPG family
SPB_RS08750	COG1694	Mazg nucleotide pyrophosphohydrolase
SPB_RS08770	COG4978	Transcriptional regulator
SPB_RS08770	COG0789	Transcriptional regulator
SPB_RS08775	COG1122	ATPase activity
SPB_RS08830	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPB_RS08850	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SPB_RS08855	COG1785	Belongs to the alkaline phosphatase family
SPB_RS08860	COG1309	transcriptional regulator
SPB_RS08880	COG3842	ATPase activity
SPB_RS08900	COG0395	ABC-type sugar transport system, permease component
SPB_RS08905	COG1175	transmembrane transport
SPB_RS08910	COG2076	Multidrug Resistance protein
SPB_RS08925	COG1882	Formate acetyltransferase
SPB_RS08935	COG2390	Transcriptional regulator
SPB_RS08940	COG1349	DNA-binding transcription factor activity
SPB_RS08945	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPB_RS08955	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SPB_RS08970	COG2918	glutathione biosynthetic process
SPB_RS08970	COG1181	Belongs to the D-alanine--D-alanine ligase family
SPB_RS08990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPB_RS08995	COG1428	Deoxynucleoside kinase
SPB_RS09000	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPB_RS09005	COG4120	Belongs to the binding-protein-dependent transport system permease family
SPB_RS09025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPB_RS09030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPB_RS09040	COG1363	Peptidase, m42
SPB_RS09045	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPB_RS09050	COG1266	CAAX protease self-immunity
SPB_RS09065	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SPB_RS09100	COG1459	type II secretion system
SPB_RS09105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPB_RS09115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SPB_RS09125	COG4499	WXG100 protein secretion system (Wss), protein YukC
SPB_RS09125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPB_RS09135	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPB_RS09140	COG1121	(ABC) transporter
SPB_RS09150	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SPB_RS09155	COG0142	geranyltranstransferase activity
SPB_RS09160	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SPB_RS09165	COG4988	ABC transporter
SPB_RS09170	COG1294	oxidase, subunit
SPB_RS09175	COG1271	oxidase subunit
SPB_RS09180	COG1252	NADH dehydrogenase
SPB_RS09215	COG2801	Transposase and inactivated derivatives
SPB_RS09275	COG2199	diguanylate cyclase activity
SPB_RS09285	COG2723	6-phospho-beta-galactosidase activity
SPB_RS09290	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SPB_RS09295	COG2723	6-phospho-beta-galactosidase activity
SPB_RS09300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPB_RS09305	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPB_RS09310	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPB_RS09325	COG3655	Transcriptional regulator
SPB_RS09340	COG1136	(ABC) transporter
SPB_RS09345	COG0577	efflux transmembrane transporter activity
SPB_RS09360	COG2226	methyltransferase
SPB_RS09365	COG3708	Transcriptional regulator
SPB_RS09365	COG2207	Transcriptional regulator
SPB_RS09400	COG0582	viral genome integration into host DNA
SPB_RS09505	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SPB_RS09520	COG0201	protein transport
SPB_RS09525	COG0200	Binds to the 23S rRNA
SPB_RS09530	COG1841	ribosomal large subunit assembly
SPB_RS09560	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SPB_RS09570	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SPB_RS09585	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SPB_RS09590	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SPB_RS09605	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SPB_RS09610	COG0089	rRNA binding
SPB_RS09615	COG0088	Forms part of the polypeptide exit tunnel
SPB_RS09625	COG0051	transcription antitermination factor activity, RNA binding
SPB_RS09630	COG0534	Mate efflux family protein
SPB_RS09640	COG1454	alcohol dehydrogenase
SPB_RS09640	COG1012	belongs to the aldehyde dehydrogenase family
SPB_RS09655	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPB_RS09660	COG2255	four-way junction helicase activity
SPB_RS09670	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPB_RS09685	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPB_RS09690	COG0151	Belongs to the GarS family
SPB_RS09710	COG0138	bifunctional purine biosynthesis protein purh
SPB_RS09715	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPB_RS09720	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SPB_RS09730	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPB_RS09735	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SPB_RS09740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPB_RS09745	COG0416	fatty acid biosynthetic process
SPB_RS09750	COG1381	Involved in DNA repair and RecF pathway recombination
SPB_RS09755	COG0436	Aminotransferase
SPB_RS09765	COG3942	CHAP domain
SPB_RS09885	COG0531	amino acid
SPB_RS09890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPB_RS09915	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPB_RS09920	COG2244	polysaccharide biosynthetic process
SPB_RS09925	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPB_RS09930	COG0193	aminoacyl-tRNA hydrolase activity
SPB_RS09935	COG0012	GTP binding
SPB_RS09950	COG0592	DNA-directed DNA polymerase activity
SPB_RS09955	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SPB_RS09960	COG1475	DNA binding
SPB_RS09965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPB_RS09995	COG0488	(ABC) transporter
SPB_RS10000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPB_RS10010	COG0517	IMP dehydrogenase activity
SPB_RS10010	COG0516	GMP reductase activity
SPB_RS10030	COG0612	Peptidase, M16
SPB_RS10040	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPB_RS10060	COG0741	lytic transglycosylase activity
SPB_RS10070	COG1760	l-serine dehydratase
SPB_RS10075	COG1760	l-serine dehydratase
SPB_RS10100	COG0359	binds to the 23S rRNA
SPB_RS10105	COG0305	Participates in initiation and elongation during chromosome replication
SPB_RS10130	COG1051	belongs to the nudix hydrolase family
SPB_RS10145	COG1309	transcriptional regulator
SPB_RS10150	COG3759	membrane
SPB_RS10165	COG1695	Transcriptional regulator
SPB_RS10175	COG0701	Predicted permease
SPB_RS10185	COG1250	3-hydroxyacyl-CoA dehydrogenase
SPB_RS10190	COG1960	acyl-CoA dehydrogenase activity
SPB_RS10195	COG0183	Belongs to the thiolase family
SPB_RS10200	COG1250	3-hydroxyacyl-CoA dehydrogenase
SPB_RS10205	COG0318	PFAM AMP-dependent synthetase and ligase
SPB_RS10260	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPB_RS10265	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPB_RS10270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPB_RS10275	COG0018	arginyl-trna synthetase
SPB_RS10280	COG1438	arginine binding
SPB_RS10290	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SPB_RS10305	COG0632	four-way junction helicase activity
SPB_RS10310	COG0519	Catalyzes the synthesis of GMP from XMP
SPB_RS10320	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SPB_RS10325	COG1393	Belongs to the ArsC family
SPB_RS10330	COG4472	Bacterial protein of unknown function (DUF965)
SPB_RS10335	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SPB_RS10340	COG3906	Belongs to the UPF0473 family
SPB_RS10350	COG1328	CTP reductase activity
SPB_RS10365	COG0602	queuosine metabolic process
SPB_RS10370	COG3022	response to hydroperoxide
SPB_RS10375	COG2514	catechol 2,3-dioxygenase activity
SPB_RS10380	COG1733	regulation of RNA biosynthetic process
SPB_RS10385	COG2188	Transcriptional regulator
SPB_RS10390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPB_RS10390	COG1263	PTS System
SPB_RS10395	COG0366	Alpha amylase catalytic
SPB_RS10400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPB_RS10415	COG3959	Transketolase, thiamine diphosphate binding domain
SPB_RS10420	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPB_RS10425	COG3590	peptidase
SPB_RS10430	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SPB_RS10445	COG0450	alkyl hydroperoxide reductase
SPB_RS10460	COG0400	carboxylic ester hydrolase activity
SPB_RS10465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SPB_RS10470	COG0346	lactoylglutathione lyase activity
SPB_RS10475	COG0346	lactoylglutathione lyase activity
SPB_RS10480	COG0025	NhaP-type Na H and K H
SPB_RS10510	COG0459	protein refolding
SPB_RS10530	COG0564	pseudouridine synthase activity
SPB_RS10545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPB_RS10565	COG0495	leucyl-tRNA aminoacylation
SPB_RS10570	COG1929	Belongs to the glycerate kinase type-1 family
SPB_RS10595	COG3623	hexulose-6-phosphate isomerase
SPB_RS10620	COG3448	diguanylate cyclase activity
SPB_RS10620	COG4175	Glycine betaine
SPB_RS10630	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPB_RS10630	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPB_RS10635	COG1832	CoA-binding protein
SPB_RS10650	COG0343	queuine tRNA-ribosyltransferase activity
SPB_RS10660	COG1268	BioY protein
SPB_RS10665	COG1234	tRNA 3'-trailer cleavage
SPB_RS10715	COG0166	Belongs to the GPI family
SPB_RS10725	COG3711	transcriptional antiterminator
SPB_RS10725	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPB_RS10735	COG3730	PTS system glucitol sorbitol-specific
SPB_RS10740	COG3732	PTS system glucitol sorbitol-specific
SPB_RS10750	COG2171	N-acyltransferase activity
SPB_RS10755	COG1473	amidohydrolase
SPB_RS10760	COG1215	transferase activity, transferring glycosyl groups
SPB_RS10765	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SPB_RS10775	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPB_RS10785	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPB_RS10790	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SPB_RS10800	COG1132	(ABC) transporter
SPB_RS10805	COG1132	(ABC) transporter
SPB_RS10810	COG1053	succinate dehydrogenase
SPB_RS10810	COG3976	FMN-binding domain protein
SPB_RS10810	COG0431	NADPH-dependent FMN reductase
SPB_RS10820	COG2832	Protein of unknown function (DUF454)
SPB_RS10890	COG0697	spore germination
SPB_RS10890	COG1674	ftsk spoiiie
SPB_RS10915	COG1388	LysM domain
SPB_RS10915	COG4932	domain protein
SPB_RS10920	COG3620	sequence-specific DNA binding