locus-tag	class	description
SPSF3K_RS00005	COG1475	DNA binding
SPSF3K_RS00010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPSF3K_RS00040	COG0488	(ABC) transporter
SPSF3K_RS00045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPSF3K_RS00055	COG0517	IMP dehydrogenase activity
SPSF3K_RS00055	COG0516	GMP reductase activity
SPSF3K_RS00075	COG0612	Peptidase, M16
SPSF3K_RS00085	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPSF3K_RS00105	COG0741	lytic transglycosylase activity
SPSF3K_RS00115	COG1760	l-serine dehydratase
SPSF3K_RS00120	COG1760	l-serine dehydratase
SPSF3K_RS00145	COG0359	binds to the 23S rRNA
SPSF3K_RS00150	COG0305	Participates in initiation and elongation during chromosome replication
SPSF3K_RS00185	COG1309	transcriptional regulator
SPSF3K_RS00190	COG3759	membrane
SPSF3K_RS00205	COG1695	Transcriptional regulator
SPSF3K_RS00215	COG0701	Predicted permease
SPSF3K_RS00225	COG1250	3-hydroxyacyl-CoA dehydrogenase
SPSF3K_RS00230	COG1960	acyl-CoA dehydrogenase activity
SPSF3K_RS00235	COG0183	Belongs to the thiolase family
SPSF3K_RS00240	COG1250	3-hydroxyacyl-CoA dehydrogenase
SPSF3K_RS00245	COG0318	PFAM AMP-dependent synthetase and ligase
SPSF3K_RS00255	COG2508	Transcriptional regulator
SPSF3K_RS00280	COG2816	NAD+ diphosphatase activity
SPSF3K_RS00315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPSF3K_RS00320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPSF3K_RS00325	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPSF3K_RS00330	COG0018	arginyl-trna synthetase
SPSF3K_RS00335	COG1438	arginine binding
SPSF3K_RS00345	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SPSF3K_RS00450	COG0582	viral genome integration into host DNA
SPSF3K_RS00465	COG0632	four-way junction helicase activity
SPSF3K_RS00470	COG0519	Catalyzes the synthesis of GMP from XMP
SPSF3K_RS00480	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SPSF3K_RS00485	COG1393	Belongs to the ArsC family
SPSF3K_RS00490	COG4472	Bacterial protein of unknown function (DUF965)
SPSF3K_RS00495	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SPSF3K_RS00500	COG3906	Belongs to the UPF0473 family
SPSF3K_RS00510	COG1328	CTP reductase activity
SPSF3K_RS00525	COG0602	queuosine metabolic process
SPSF3K_RS00530	COG3022	response to hydroperoxide
SPSF3K_RS00535	COG2514	catechol 2,3-dioxygenase activity
SPSF3K_RS00540	COG1733	regulation of RNA biosynthetic process
SPSF3K_RS00545	COG2188	Transcriptional regulator
SPSF3K_RS00550	COG1263	PTS System
SPSF3K_RS00550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPSF3K_RS00555	COG0366	Alpha amylase catalytic
SPSF3K_RS00560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPSF3K_RS00575	COG3959	Transketolase, thiamine diphosphate binding domain
SPSF3K_RS00580	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPSF3K_RS00585	COG3590	peptidase
SPSF3K_RS00590	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SPSF3K_RS00605	COG0450	alkyl hydroperoxide reductase
SPSF3K_RS00625	COG0400	carboxylic ester hydrolase activity
SPSF3K_RS00630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SPSF3K_RS00635	COG0346	lactoylglutathione lyase activity
SPSF3K_RS00640	COG0346	lactoylglutathione lyase activity
SPSF3K_RS00645	COG0025	NhaP-type Na H and K H
SPSF3K_RS00675	COG0459	protein refolding
SPSF3K_RS00695	COG0564	pseudouridine synthase activity
SPSF3K_RS00710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPSF3K_RS00735	COG0495	leucyl-tRNA aminoacylation
SPSF3K_RS00740	COG1929	Belongs to the glycerate kinase type-1 family
SPSF3K_RS00765	COG3623	hexulose-6-phosphate isomerase
SPSF3K_RS00790	COG4175	Glycine betaine
SPSF3K_RS00790	COG3448	diguanylate cyclase activity
SPSF3K_RS00800	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPSF3K_RS00800	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPSF3K_RS00805	COG1832	CoA-binding protein
SPSF3K_RS00820	COG0343	queuine tRNA-ribosyltransferase activity
SPSF3K_RS00830	COG1268	BioY protein
SPSF3K_RS00835	COG1234	tRNA 3'-trailer cleavage
SPSF3K_RS00855	COG0166	Belongs to the GPI family
SPSF3K_RS00865	COG3711	transcriptional antiterminator
SPSF3K_RS00865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPSF3K_RS00875	COG3730	PTS system glucitol sorbitol-specific
SPSF3K_RS00880	COG3732	PTS system glucitol sorbitol-specific
SPSF3K_RS00890	COG2171	N-acyltransferase activity
SPSF3K_RS00895	COG1473	amidohydrolase
SPSF3K_RS00900	COG1215	transferase activity, transferring glycosyl groups
SPSF3K_RS00905	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SPSF3K_RS00915	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPSF3K_RS00925	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPSF3K_RS00930	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SPSF3K_RS00940	COG1132	(ABC) transporter
SPSF3K_RS00945	COG1132	(ABC) transporter
SPSF3K_RS00950	COG1053	succinate dehydrogenase
SPSF3K_RS00950	COG3976	FMN-binding domain protein
SPSF3K_RS00950	COG0431	NADPH-dependent FMN reductase
SPSF3K_RS00960	COG2832	Protein of unknown function (DUF454)
SPSF3K_RS00965	COG0756	dUTP diphosphatase activity
SPSF3K_RS00995	COG3290	protein histidine kinase activity
SPSF3K_RS01020	COG0165	Argininosuccinate lyase
SPSF3K_RS01025	COG0594	ribonuclease P activity
SPSF3K_RS01035	COG1847	R3H domain protein
SPSF3K_RS01045	COG1131	(ABC) transporter
SPSF3K_RS01070	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SPSF3K_RS01080	COG0395	ABC-type sugar transport system, permease component
SPSF3K_RS01085	COG1653	transport
SPSF3K_RS01095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPSF3K_RS01110	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPSF3K_RS01110	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPSF3K_RS01110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPSF3K_RS01115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPSF3K_RS01115	COG3711	transcriptional antiterminator
SPSF3K_RS01120	COG0084	hydrolase, TatD family'
SPSF3K_RS01135	COG2226	methyltransferase
SPSF3K_RS01145	COG2814	Major facilitator Superfamily
SPSF3K_RS01180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPSF3K_RS01190	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SPSF3K_RS01200	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SPSF3K_RS01205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SPSF3K_RS01210	COG0126	phosphoglycerate kinase activity
SPSF3K_RS01220	COG0789	Transcriptional regulator
SPSF3K_RS01225	COG0174	glutamine synthetase
SPSF3K_RS01230	COG4166	transmembrane transport
SPSF3K_RS01235	COG0601	transmembrane transport
SPSF3K_RS01240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPSF3K_RS01245	COG0444	Belongs to the ABC transporter superfamily
SPSF3K_RS01250	COG4608	Belongs to the ABC transporter superfamily
SPSF3K_RS01260	COG5503	Protein of unknown function (DUF1447)
SPSF3K_RS01265	COG1214	PFAM Peptidase M22, glycoprotease
SPSF3K_RS01285	COG2081	HI0933 family
SPSF3K_RS01295	COG2176	DNA-directed DNA polymerase activity
SPSF3K_RS01305	COG1609	Transcriptional regulator
SPSF3K_RS01310	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
SPSF3K_RS01320	COG1028	Short-chain dehydrogenase reductase Sdr
SPSF3K_RS01330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPSF3K_RS01340	COG2348	transferase activity, transferring amino-acyl groups
SPSF3K_RS01345	COG0673	inositol 2-dehydrogenase activity
SPSF3K_RS01355	COG2814	Major facilitator Superfamily
SPSF3K_RS01360	COG2723	6-phospho-beta-galactosidase activity
SPSF3K_RS01370	COG3655	Transcriptional regulator
SPSF3K_RS01390	COG2828	Protein conserved in bacteria
SPSF3K_RS01395	COG2851	Citrate transporter
SPSF3K_RS01400	COG0583	DNA-binding transcription factor activity
SPSF3K_RS01405	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SPSF3K_RS01410	COG3180	Ammonia monooxygenase
SPSF3K_RS01415	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
SPSF3K_RS01425	COG2851	Citrate transporter
SPSF3K_RS01435	COG0511	ligase activity, forming carbon-carbon bonds
SPSF3K_RS01440	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SPSF3K_RS01445	COG3052	prosthetic group binding
SPSF3K_RS01470	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SPSF3K_RS01485	COG1609	Transcriptional regulator
SPSF3K_RS01490	COG4209	transmembrane transport
SPSF3K_RS01495	COG0395	ABC-type sugar transport system, permease component
SPSF3K_RS01510	COG1940	carbohydrate kinase activity
SPSF3K_RS01530	COG2936	dipeptidyl-peptidase activity
SPSF3K_RS01550	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPSF3K_RS01560	COG2153	protein acetylation
SPSF3K_RS01565	COG1882	Formate acetyltransferase
SPSF3K_RS01580	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPSF3K_RS01585	COG0681	Belongs to the peptidase S26 family
SPSF3K_RS01590	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SPSF3K_RS01605	COG1193	negative regulation of DNA recombination
SPSF3K_RS01610	COG3118	belongs to the thioredoxin family
SPSF3K_RS01620	COG1194	a g-specific adenine glycosylase
SPSF3K_RS01655	COG0006	proline dipeptidase activity
SPSF3K_RS01660	COG2131	deaminase
SPSF3K_RS01675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPSF3K_RS01680	COG1609	Transcriptional regulator
SPSF3K_RS01685	COG1621	beta-fructofuranosidase activity
SPSF3K_RS01690	COG1263	PTS System
SPSF3K_RS01690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPSF3K_RS01690	COG2190	(PTS) system
SPSF3K_RS01695	COG1940	carbohydrate kinase activity
SPSF3K_RS01705	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPSF3K_RS01710	COG2723	6-phospho-beta-galactosidase activity
SPSF3K_RS01715	COG1482	cell wall glycoprotein biosynthetic process
SPSF3K_RS01725	COG0653	protein targeting
SPSF3K_RS01730	COG0736	holo-[acyl-carrier-protein] synthase activity
SPSF3K_RS01735	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SPSF3K_RS01740	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPSF3K_RS01745	COG4989	oxidoreductase activity
SPSF3K_RS01750	COG0252	asparaginase activity
SPSF3K_RS01755	COG0561	phosphatase activity
SPSF3K_RS01760	COG0589	response to stress
SPSF3K_RS01765	COG0436	Aminotransferase
SPSF3K_RS01770	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SPSF3K_RS01775	COG1335	isochorismatase
SPSF3K_RS01780	COG1937	Protein conserved in bacteria
SPSF3K_RS01785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPSF3K_RS01790	COG0446	pyridine nucleotide-disulphide oxidoreductase
SPSF3K_RS01860	COG1252	NADH dehydrogenase
SPSF3K_RS01865	COG1271	oxidase subunit
SPSF3K_RS01870	COG1294	oxidase, subunit
SPSF3K_RS01875	COG4988	ABC transporter
SPSF3K_RS01880	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SPSF3K_RS01885	COG0142	geranyltranstransferase activity
SPSF3K_RS01890	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SPSF3K_RS01900	COG1121	(ABC) transporter
SPSF3K_RS01905	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPSF3K_RS01915	COG4499	WXG100 protein secretion system (Wss), protein YukC
SPSF3K_RS01915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPSF3K_RS01925	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SPSF3K_RS01935	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPSF3K_RS01940	COG1459	type II secretion system
SPSF3K_RS01975	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SPSF3K_RS01990	COG1266	CAAX protease self-immunity
SPSF3K_RS01995	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPSF3K_RS02000	COG1363	Peptidase, m42
SPSF3K_RS02010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPSF3K_RS02015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPSF3K_RS02035	COG4120	Belongs to the binding-protein-dependent transport system permease family
SPSF3K_RS02040	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPSF3K_RS02045	COG1428	Deoxynucleoside kinase
SPSF3K_RS02050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPSF3K_RS02070	COG2918	glutathione biosynthetic process
SPSF3K_RS02070	COG1181	Belongs to the D-alanine--D-alanine ligase family
SPSF3K_RS02085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SPSF3K_RS02095	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPSF3K_RS02100	COG1349	DNA-binding transcription factor activity
SPSF3K_RS02105	COG2390	Transcriptional regulator
SPSF3K_RS02115	COG1882	Formate acetyltransferase
SPSF3K_RS02130	COG2076	Multidrug Resistance protein
SPSF3K_RS02135	COG1175	transmembrane transport
SPSF3K_RS02140	COG0395	ABC-type sugar transport system, permease component
SPSF3K_RS02160	COG3842	ATPase activity
SPSF3K_RS02180	COG1309	transcriptional regulator
SPSF3K_RS02185	COG1785	Belongs to the alkaline phosphatase family
SPSF3K_RS02205	COG1175	transmembrane transport
SPSF3K_RS02210	COG0395	ABC-type sugar transport system, permease component
SPSF3K_RS02215	COG3250	beta-galactosidase activity
SPSF3K_RS02225	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SPSF3K_RS02245	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPSF3K_RS02315	COG4978	Transcriptional regulator
SPSF3K_RS02315	COG0789	Transcriptional regulator
SPSF3K_RS02335	COG1694	Mazg nucleotide pyrophosphohydrolase
SPSF3K_RS02340	COG2094	Belongs to the DNA glycosylase MPG family
SPSF3K_RS02355	COG4978	Transcriptional regulator
SPSF3K_RS02355	COG0789	Transcriptional regulator
SPSF3K_RS02360	COG2217	Heavy metal translocating P-type atpase
SPSF3K_RS02375	COG0583	DNA-binding transcription factor activity
SPSF3K_RS02380	COG0281	malic enzyme
SPSF3K_RS02405	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPSF3K_RS02430	COG2264	protein methyltransferase activity
SPSF3K_RS02435	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPSF3K_RS02450	COG1609	Transcriptional regulator
SPSF3K_RS02455	COG1263	PTS System
SPSF3K_RS02455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPSF3K_RS02455	COG2190	(PTS) system
SPSF3K_RS02470	COG1363	Peptidase, m42
SPSF3K_RS02490	COG1490	D-aminoacyl-tRNA deacylase activity
SPSF3K_RS02510	COG3842	ATPase activity
SPSF3K_RS02525	COG1609	Transcriptional regulator
SPSF3K_RS02530	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPSF3K_RS02535	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPSF3K_RS02540	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPSF3K_RS02550	COG1862	Preprotein translocase
SPSF3K_RS02560	COG4589	Belongs to the CDS family
SPSF3K_RS02600	COG0242	peptide deformylase activity
SPSF3K_RS02610	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SPSF3K_RS02615	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SPSF3K_RS02615	COG0248	Ppx GppA phosphatase
SPSF3K_RS02625	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SPSF3K_RS02640	COG1045	serine acetyltransferase
SPSF3K_RS02650	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPSF3K_RS02660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPSF3K_RS02680	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPSF3K_RS02690	COG4974	Belongs to the 'phage' integrase family
SPSF3K_RS02755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPSF3K_RS02775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPSF3K_RS02795	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPSF3K_RS02810	COG1511	domain protein
SPSF3K_RS02830	COG1122	ATPase activity
SPSF3K_RS02835	COG4720	Psort location CytoplasmicMembrane, score
SPSF3K_RS02875	COG0527	aspartate kinase activity
SPSF3K_RS02880	COG0101	tRNA pseudouridine synthase activity
SPSF3K_RS02885	COG0352	thiamine-phosphate diphosphorylase activity
SPSF3K_RS02885	COG0351	phosphomethylpyrimidine kinase
SPSF3K_RS02890	COG4720	Psort location CytoplasmicMembrane, score
SPSF3K_RS02900	COG0668	transmembrane transport
SPSF3K_RS02905	COG0544	peptidyl-prolyl cis-trans isomerase activity
SPSF3K_RS02910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPSF3K_RS02915	COG3343	RNA polymerase activity
SPSF3K_RS02925	COG3275	phosphorelay sensor kinase activity
SPSF3K_RS02930	COG3279	Response regulator of the LytR AlgR family
SPSF3K_RS02940	COG1346	cytolysis
SPSF3K_RS02990	COG1126	abc transporter atp-binding protein
SPSF3K_RS02995	COG0765	amino acid transport
SPSF3K_RS03015	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPSF3K_RS03025	COG0719	Fe-S assembly protein
SPSF3K_RS03030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPSF3K_RS03040	COG0719	Fe-S assembly protein
SPSF3K_RS03045	COG1686	Belongs to the peptidase S11 family
SPSF3K_RS03055	COG1686	Belongs to the peptidase S11 family
SPSF3K_RS03060	COG4166	transmembrane transport
SPSF3K_RS03065	COG0601	transmembrane transport
SPSF3K_RS03070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPSF3K_RS03075	COG0444	Belongs to the ABC transporter superfamily
SPSF3K_RS03120	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SPSF3K_RS03125	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPSF3K_RS03130	COG1534	Rna-binding protein
SPSF3K_RS03140	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPSF3K_RS03145	COG1335	isochorismatase
SPSF3K_RS03150	COG0799	negative regulation of ribosome biogenesis
SPSF3K_RS03155	COG2226	methyltransferase
SPSF3K_RS03165	COG0789	Transcriptional regulator
SPSF3K_RS03180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPSF3K_RS03185	COG1464	Belongs to the NlpA lipoprotein family
SPSF3K_RS03205	COG0569	domain protein
SPSF3K_RS03210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPSF3K_RS03215	COG0357	Ribosomal RNA small subunit methyltransferase G
SPSF3K_RS03220	COG1704	LemA family
SPSF3K_RS03225	COG0501	Belongs to the peptidase M48B family
SPSF3K_RS03235	COG0745	RESPONSE REGULATOR receiver
SPSF3K_RS03245	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPSF3K_RS03255	COG1484	DNA-dependent DNA replication
SPSF3K_RS03265	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPSF3K_RS03285	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPSF3K_RS03300	COG1254	Belongs to the acylphosphatase family
SPSF3K_RS03305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPSF3K_RS03330	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SPSF3K_RS03355	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SPSF3K_RS03365	COG1187	pseudouridine synthase activity
SPSF3K_RS03370	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SPSF3K_RS03380	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPSF3K_RS03385	COG0671	phosphoesterase, PA-phosphatase related
SPSF3K_RS03510	COG1242	4 iron, 4 sulfur cluster binding
SPSF3K_RS03515	COG1131	(ABC) transporter
SPSF3K_RS03525	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPSF3K_RS03530	COG1253	flavin adenine dinucleotide binding
SPSF3K_RS03535	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPSF3K_RS03540	COG1227	inorganic diphosphatase activity
SPSF3K_RS03555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPSF3K_RS03560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPSF3K_RS03565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPSF3K_RS03570	COG1120	ATPase activity
SPSF3K_RS03580	COG2244	polysaccharide biosynthetic process
SPSF3K_RS03590	COG0740	serine-type endopeptidase activity
SPSF3K_RS03630	COG0517	IMP dehydrogenase activity
SPSF3K_RS03640	COG0470	DNA polymerase III
SPSF3K_RS03645	COG1774	PSP1 C-terminal conserved region
SPSF3K_RS03670	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SPSF3K_RS03680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SPSF3K_RS03690	COG1393	Belongs to the ArsC family
SPSF3K_RS03705	COG0346	lactoylglutathione lyase activity
SPSF3K_RS03715	COG0708	Exodeoxyribonuclease III
SPSF3K_RS03720	COG0640	Transcriptional regulator
SPSF3K_RS03750	COG1114	Component of the transport system for branched-chain amino acids
SPSF3K_RS03765	COG1028	Short-chain dehydrogenase reductase Sdr
SPSF3K_RS03770	COG0673	inositol 2-dehydrogenase activity
SPSF3K_RS03775	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SPSF3K_RS03790	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPSF3K_RS03840	COG0081	regulation of translation
SPSF3K_RS03855	COG2996	Protein conserved in bacteria
SPSF3K_RS03885	COG1702	phosphate starvation-inducible protein PhoH
SPSF3K_RS03890	COG1573	uracil-dna glycosylase
SPSF3K_RS03895	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SPSF3K_RS03900	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPSF3K_RS03910	COG0494	nUDIX hydrolase
SPSF3K_RS03935	COG1131	(ABC) transporter
SPSF3K_RS03960	COG2364	Membrane
SPSF3K_RS03965	COG0433	COG0433 Predicted ATPase
SPSF3K_RS03970	COG2814	Major facilitator Superfamily
SPSF3K_RS03985	COG0557	exoribonuclease II activity
SPSF3K_RS03990	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SPSF3K_RS04000	COG0346	lactoylglutathione lyase activity
SPSF3K_RS04005	COG0778	Nitroreductase
SPSF3K_RS04010	COG2723	6-phospho-beta-galactosidase activity
SPSF3K_RS04025	COG3711	transcriptional antiterminator
SPSF3K_RS04025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPSF3K_RS04030	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPSF3K_RS04040	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPSF3K_RS04060	COG1609	Transcriptional regulator
SPSF3K_RS04075	COG0438	transferase activity, transferring glycosyl groups
SPSF3K_RS04080	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SPSF3K_RS04090	COG2376	Dihydroxyacetone kinase
SPSF3K_RS04100	COG2376	Dihydroxyacetone kinase
SPSF3K_RS04105	COG1461	Dihydroxyacetone kinase
SPSF3K_RS04110	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SPSF3K_RS04115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPSF3K_RS04125	COG0765	amino acid transport
SPSF3K_RS04130	COG0765	amino acid transport
SPSF3K_RS04135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPSF3K_RS04145	COG0745	RESPONSE REGULATOR receiver
SPSF3K_RS04150	COG5002	protein histidine kinase activity
SPSF3K_RS04155	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPSF3K_RS04160	COG0571	ribonuclease III activity
SPSF3K_RS04165	COG1196	nuclear chromosome segregation
SPSF3K_RS04170	COG0561	phosphatase activity
SPSF3K_RS04175	COG0561	phosphatase activity
SPSF3K_RS04180	COG0552	protein localization to endoplasmic reticulum
SPSF3K_RS04190	COG2814	Major facilitator Superfamily
SPSF3K_RS04195	COG3689	TIGRFAM TIGR03943 family protein
SPSF3K_RS04200	COG0701	Predicted permease
SPSF3K_RS04205	COG0346	lactoylglutathione lyase activity
SPSF3K_RS04210	COG0745	RESPONSE REGULATOR receiver
SPSF3K_RS04215	COG5002	protein histidine kinase activity
SPSF3K_RS04220	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPSF3K_RS04225	COG0573	inorganic phosphate transmembrane transporter activity
SPSF3K_RS04235	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPSF3K_RS04240	COG0704	Plays a role in the regulation of phosphate uptake
SPSF3K_RS04245	COG2183	response to ionizing radiation
SPSF3K_RS04250	COG3091	SprT-like family
SPSF3K_RS04260	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SPSF3K_RS04290	COG0826	peptidase U32
SPSF3K_RS04300	COG4443	Transcriptional Coactivator p15 (PC4)
SPSF3K_RS04305	COG4166	transmembrane transport
SPSF3K_RS04325	COG1228	amidohydrolase
SPSF3K_RS04330	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SPSF3K_RS04340	COG3404	Formiminotransferase-cyclodeaminase
SPSF3K_RS04355	COG0531	amino acid
SPSF3K_RS04360	COG2986	histidine ammonia-lyase
SPSF3K_RS04365	COG0010	Belongs to the arginase family
SPSF3K_RS04385	COG0406	alpha-ribazole phosphatase activity
SPSF3K_RS04390	COG3304	Inner membrane component domain
SPSF3K_RS04400	COG3859	Proton-coupled thiamine transporter YuaJ
SPSF3K_RS04420	COG1164	Oligoendopeptidase f
SPSF3K_RS04430	COG0772	Belongs to the SEDS family
SPSF3K_RS04450	COG2348	transferase activity, transferring amino-acyl groups
SPSF3K_RS04460	COG1078	dGTPase activity
SPSF3K_RS04485	COG0584	glycerophosphoryl diester phosphodiesterase
SPSF3K_RS04500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPSF3K_RS04505	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
SPSF3K_RS04510	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SPSF3K_RS04520	COG2884	Cell division ATP-binding protein ftsE
SPSF3K_RS04525	COG2177	Part of the ABC transporter FtsEX involved in
SPSF3K_RS04540	COG0436	Aminotransferase
SPSF3K_RS04545	COG0017	Asparaginyl-tRNA synthetase
SPSF3K_RS04555	COG1660	Displays ATPase and GTPase activities
SPSF3K_RS04580	COG2188	Transcriptional regulator
SPSF3K_RS04585	COG2222	sugar isomerase
SPSF3K_RS04610	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPSF3K_RS04610	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPSF3K_RS04615	COG3715	PTS system
SPSF3K_RS04620	COG3716	PTS system mannose fructose sorbose family IID component
SPSF3K_RS04640	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPSF3K_RS04645	COG2153	protein acetylation
SPSF3K_RS04650	COG0625	glutathione transferase activity
SPSF3K_RS04660	COG0716	FMN binding
SPSF3K_RS04665	COG0077	Prephenate dehydratase
SPSF3K_RS04665	COG1605	Chorismate mutase
SPSF3K_RS04670	COG0038	chloride channel
SPSF3K_RS04675	COG0335	large ribosomal subunit rRNA binding
SPSF3K_RS04690	COG0772	Belongs to the SEDS family
SPSF3K_RS04705	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SPSF3K_RS04710	COG0560	Phosphoserine phosphatase
SPSF3K_RS04730	COG0148	phosphopyruvate hydratase activity
SPSF3K_RS04735	COG2031	fatty acid transporter
SPSF3K_RS04750	COG0183	Belongs to the thiolase family
SPSF3K_RS04775	COG1269	ATP hydrolysis coupled proton transport
SPSF3K_RS04780	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPSF3K_RS04795	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
SPSF3K_RS04815	COG0778	Nitroreductase
SPSF3K_RS04830	COG4708	membrane
SPSF3K_RS04835	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SPSF3K_RS04840	COG1597	lipid kinase activity
SPSF3K_RS04845	COG1523	belongs to the glycosyl hydrolase 13 family
SPSF3K_RS04850	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SPSF3K_RS04860	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SPSF3K_RS04865	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SPSF3K_RS04870	COG0297	glycogen (starch) synthase activity
SPSF3K_RS04875	COG0058	SHG alpha-glucan phosphorylase activity
SPSF3K_RS04895	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPSF3K_RS04905	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SPSF3K_RS04910	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SPSF3K_RS04915	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SPSF3K_RS04925	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPSF3K_RS04950	COG0072	phenylalanine-tRNA ligase activity
SPSF3K_RS04950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPSF3K_RS04965	COG0577	efflux transmembrane transporter activity
SPSF3K_RS04970	COG1136	(ABC) transporter
SPSF3K_RS04975	COG2321	neutral zinc metallopeptidase
SPSF3K_RS04980	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SPSF3K_RS04985	COG1074	ATP-dependent DNA helicase activity
SPSF3K_RS04990	COG0436	Aminotransferase
SPSF3K_RS04995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPSF3K_RS05005	COG1970	mechanosensitive ion channel activity
SPSF3K_RS05010	COG0358	DNA primase activity
SPSF3K_RS05015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPSF3K_RS05020	COG2151	metal-sulfur cluster biosynthetic enzyme
SPSF3K_RS05035	COG1442	glycosyl transferase family 8
SPSF3K_RS05035	COG1216	Glycosyl transferase, family 2
SPSF3K_RS05050	COG0438	transferase activity, transferring glycosyl groups
SPSF3K_RS05060	COG1368	sulfuric ester hydrolase activity
SPSF3K_RS05075	COG2246	polysaccharide biosynthetic process
SPSF3K_RS05115	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SPSF3K_RS05120	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SPSF3K_RS05125	COG1368	sulfuric ester hydrolase activity
SPSF3K_RS05130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPSF3K_RS05150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPSF3K_RS05155	COG0285	dihydrofolate synthase activity
SPSF3K_RS05165	COG1104	cysteine desulfurase activity
SPSF3K_RS05170	COG0301	tRNA thio-modification
SPSF3K_RS05190	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SPSF3K_RS05195	COG0583	DNA-binding transcription factor activity
SPSF3K_RS05205	COG0564	pseudouridine synthase activity
SPSF3K_RS05210	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SPSF3K_RS05240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPSF3K_RS05245	COG1136	(ABC) transporter
SPSF3K_RS05250	COG0577	efflux transmembrane transporter activity
SPSF3K_RS05260	COG0228	four-way junction DNA binding
SPSF3K_RS05265	COG1837	Belongs to the UPF0109 family
SPSF3K_RS05275	COG1442	glycosyl transferase family 8
SPSF3K_RS05290	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SPSF3K_RS05295	COG0336	Belongs to the RNA methyltransferase TrmD family
SPSF3K_RS05315	COG1349	DNA-binding transcription factor activity
SPSF3K_RS05320	COG1105	Belongs to the carbohydrate kinase PfkB family
SPSF3K_RS05325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPSF3K_RS05325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPSF3K_RS05325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPSF3K_RS05330	COG3942	CHAP domain
SPSF3K_RS05330	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPSF3K_RS05335	COG1388	LysM domain
SPSF3K_RS05335	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPSF3K_RS05355	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SPSF3K_RS05365	COG0488	(ABC) transporter
SPSF3K_RS05380	COG1132	(ABC) transporter
SPSF3K_RS05385	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPSF3K_RS05390	COG0242	peptide deformylase activity
SPSF3K_RS05430	COG3425	synthase
SPSF3K_RS05440	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPSF3K_RS05450	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SPSF3K_RS05470	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SPSF3K_RS05475	COG0222	ribosome binding
SPSF3K_RS05525	COG1388	LysM domain
SPSF3K_RS05525	COG3942	CHAP domain
SPSF3K_RS05595	COG3843	relaxase mobilization nuclease domain protein
SPSF3K_RS05635	COG1028	Short-chain dehydrogenase reductase Sdr
SPSF3K_RS05645	COG3708	Transcriptional regulator
SPSF3K_RS05645	COG2207	Transcriptional regulator
SPSF3K_RS05735	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPSF3K_RS05740	COG2096	Adenosyltransferase
SPSF3K_RS05760	COG0783	Belongs to the Dps family
SPSF3K_RS05765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPSF3K_RS05775	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SPSF3K_RS05780	COG2217	Heavy metal translocating P-type atpase
SPSF3K_RS05795	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SPSF3K_RS05845	COG2226	methyltransferase
SPSF3K_RS05855	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPSF3K_RS05865	COG0551	DNA topoisomerase type I activity
SPSF3K_RS05865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPSF3K_RS05895	COG1192	Involved in chromosome partitioning
SPSF3K_RS05930	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SPSF3K_RS05945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPSF3K_RS05945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPSF3K_RS05945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPSF3K_RS05950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPSF3K_RS05980	COG3711	transcriptional antiterminator
SPSF3K_RS05985	COG2723	6-phospho-beta-galactosidase activity
SPSF3K_RS05990	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPSF3K_RS05995	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPSF3K_RS05995	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPSF3K_RS06015	COG1396	sequence-specific DNA binding
SPSF3K_RS06025	COG4974	Belongs to the 'phage' integrase family
SPSF3K_RS06040	COG0463	Glycosyl transferase, family 2
SPSF3K_RS06055	COG1486	melibiose metabolic process
SPSF3K_RS06060	COG1737	Transcriptional regulator
SPSF3K_RS06065	COG0446	pyridine nucleotide-disulphide oxidoreductase
SPSF3K_RS06070	COG0366	Alpha amylase catalytic
SPSF3K_RS06075	COG0726	polysaccharide deacetylase
SPSF3K_RS06080	COG0460	homoserine dehydrogenase
SPSF3K_RS06085	COG0083	homoserine kinase activity
SPSF3K_RS06090	COG0285	dihydrofolate synthase activity
SPSF3K_RS06095	COG0302	gtp cyclohydrolase
SPSF3K_RS06115	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SPSF3K_RS06125	COG1176	ABC-type spermidine putrescine transport system, permease component I
SPSF3K_RS06130	COG1177	transmembrane transport
SPSF3K_RS06140	COG4565	transcriptional regulatory protein
SPSF3K_RS06150	COG3493	citrate carrier protein
SPSF3K_RS06160	COG0038	chloride channel
SPSF3K_RS06165	COG3711	transcriptional antiterminator
SPSF3K_RS06170	COG1263	PTS System
SPSF3K_RS06170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPSF3K_RS06170	COG2190	(PTS) system
SPSF3K_RS06180	COG2207	Transcriptional regulator
SPSF3K_RS06185	COG2723	6-phospho-beta-galactosidase activity
SPSF3K_RS06195	COG0561	phosphatase activity
SPSF3K_RS06200	COG2723	6-phospho-beta-galactosidase activity
SPSF3K_RS06210	COG0406	alpha-ribazole phosphatase activity
SPSF3K_RS06220	COG2723	6-phospho-beta-galactosidase activity
SPSF3K_RS06225	COG0628	permease
SPSF3K_RS06230	COG2003	Belongs to the UPF0758 family
SPSF3K_RS06255	COG1104	cysteine desulfurase activity
SPSF3K_RS06270	COG2357	RelA SpoT domain protein
SPSF3K_RS06280	COG0564	pseudouridine synthase activity
SPSF3K_RS06285	COG0280	phosphate acetyltransferase
SPSF3K_RS06290	COG4221	oxidoreductase activity
SPSF3K_RS06295	COG0477	Major facilitator Superfamily
SPSF3K_RS06325	COG1174	glycine betaine transport
SPSF3K_RS06330	COG2723	6-phospho-beta-galactosidase activity
SPSF3K_RS06335	COG0516	GMP reductase activity
SPSF3K_RS06340	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPSF3K_RS06345	COG2233	PERMEase
SPSF3K_RS06370	COG2890	protein-(glutamine-N5) methyltransferase activity
SPSF3K_RS06375	COG0009	L-threonylcarbamoyladenylate synthase
SPSF3K_RS06385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SPSF3K_RS06405	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPSF3K_RS06410	COG0039	L-malate dehydrogenase activity
SPSF3K_RS06420	COG3764	Sortase (surface protein transpeptidase)
SPSF3K_RS06425	COG0346	lactoylglutathione lyase activity
SPSF3K_RS06435	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPSF3K_RS06445	COG1811	Na channel or pump
SPSF3K_RS06455	COG0386	Belongs to the glutathione peroxidase family
SPSF3K_RS06465	COG2188	Transcriptional regulator
SPSF3K_RS06475	COG2723	6-phospho-beta-galactosidase activity
SPSF3K_RS06480	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPSF3K_RS06500	COG3104	oligopeptide transport
SPSF3K_RS06560	COG2963	transposase activity
SPSF3K_RS06590	COG2188	Transcriptional regulator
SPSF3K_RS06605	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPSF3K_RS06620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPSF3K_RS06630	COG0673	inositol 2-dehydrogenase activity
SPSF3K_RS06645	COG0561	phosphatase activity
SPSF3K_RS06665	COG1263	PTS System
SPSF3K_RS06665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPSF3K_RS06670	COG1263	PTS System
SPSF3K_RS06670	COG2190	(PTS) system
SPSF3K_RS06670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPSF3K_RS06675	COG2723	6-phospho-beta-galactosidase activity
SPSF3K_RS06680	COG0604	alcohol dehydrogenase
SPSF3K_RS06685	COG0662	Cupin 2, conserved barrel domain protein
SPSF3K_RS06690	COG3976	FMN-binding domain protein
SPSF3K_RS06690	COG0431	NADPH-dependent FMN reductase
SPSF3K_RS06690	COG1053	succinate dehydrogenase
SPSF3K_RS06760	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SPSF3K_RS06760	COG2755	lipolytic protein G-D-S-L family
SPSF3K_RS06765	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPSF3K_RS06775	COG2020	methyltransferase activity
SPSF3K_RS06780	COG4974	Belongs to the 'phage' integrase family
SPSF3K_RS06785	COG1902	pentaerythritol trinitrate reductase activity
SPSF3K_RS06800	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SPSF3K_RS06805	COG0642	Histidine kinase
SPSF3K_RS06820	COG1136	(ABC) transporter
SPSF3K_RS06830	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SPSF3K_RS06855	COG0583	DNA-binding transcription factor activity
SPSF3K_RS06860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPSF3K_RS06865	COG0758	DNA mediated transformation
SPSF3K_RS06870	COG0110	maltose O-acetyltransferase activity
SPSF3K_RS06875	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SPSF3K_RS06880	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPSF3K_RS06890	COG0095	Lipoate-protein ligase
SPSF3K_RS06895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPSF3K_RS06910	COG1272	protein, Hemolysin III
SPSF3K_RS06930	COG0488	(ABC) transporter
SPSF3K_RS06935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPSF3K_RS06940	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPSF3K_RS06940	COG1328	CTP reductase activity
SPSF3K_RS06945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPSF3K_RS06950	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPSF3K_RS06955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPSF3K_RS06965	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SPSF3K_RS06975	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPSF3K_RS06980	COG4684	Psort location CytoplasmicMembrane, score
SPSF3K_RS06985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPSF3K_RS06990	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPSF3K_RS06995	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPSF3K_RS07000	COG3845	ABC transporter
SPSF3K_RS07005	COG1744	ABC transporter substrate-binding protein PnrA-like
SPSF3K_RS07010	COG0295	cytidine deaminase activity
SPSF3K_RS07015	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SPSF3K_RS07020	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SPSF3K_RS07025	COG2813	Specifically methylates the guanine in position
SPSF3K_RS07040	COG5002	protein histidine kinase activity
SPSF3K_RS07045	COG0745	RESPONSE REGULATOR receiver
SPSF3K_RS07055	COG0704	Plays a role in the regulation of phosphate uptake
SPSF3K_RS07070	COG0581	inorganic phosphate transmembrane transporter activity
SPSF3K_RS07075	COG0573	inorganic phosphate transmembrane transporter activity
SPSF3K_RS07085	COG0483	inositol monophosphate 1-phosphatase activity
SPSF3K_RS07090	COG4476	Belongs to the UPF0223 family
SPSF3K_RS07100	COG0196	riboflavin kinase activity
SPSF3K_RS07175	COG2261	transglycosylase associated protein
SPSF3K_RS07180	COG2261	transglycosylase associated protein
SPSF3K_RS07185	COG2261	transglycosylase associated protein
SPSF3K_RS07200	COG1115	amino acid carrier protein
SPSF3K_RS07205	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPSF3K_RS07210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPSF3K_RS07215	COG1126	abc transporter atp-binding protein
SPSF3K_RS07220	COG0765	amino acid transport
SPSF3K_RS07225	COG2824	Alkylphosphonate utilization operon protein PhnA
SPSF3K_RS07230	COG0246	Mannitol dehydrogenase
SPSF3K_RS07235	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPSF3K_RS07240	COG3711	transcriptional antiterminator
SPSF3K_RS07245	COG2213	PTS system mannitol-specific
SPSF3K_RS07260	COG0469	pyruvate kinase activity
SPSF3K_RS07265	COG0205	6-phosphofructokinase activity
SPSF3K_RS07275	COG1725	Transcriptional regulator
SPSF3K_RS07280	COG1131	(ABC) transporter
SPSF3K_RS07310	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPSF3K_RS07310	COG5263	repeat protein
SPSF3K_RS07345	COG3953	SLT domain
SPSF3K_RS07345	COG5280	Phage tail tape measure protein TP901
SPSF3K_RS07570	COG0539	negative regulation of cytoplasmic translation
SPSF3K_RS07590	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPSF3K_RS07600	COG0187	DNA topoisomerase II activity
SPSF3K_RS07615	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SPSF3K_RS07620	COG0765	amino acid transport
SPSF3K_RS07625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPSF3K_RS07635	COG1881	PFAM PEBP family protein
SPSF3K_RS07695	COG1215	transferase activity, transferring glycosyl groups
SPSF3K_RS07700	COG0438	transferase activity, transferring glycosyl groups
SPSF3K_RS07705	COG0110	maltose O-acetyltransferase activity
SPSF3K_RS07710	COG0438	transferase activity, transferring glycosyl groups
SPSF3K_RS07715	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPSF3K_RS07720	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPSF3K_RS07745	COG1316	TRANSCRIPTIONal
SPSF3K_RS07780	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SPSF3K_RS07790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPSF3K_RS07800	COG0322	excinuclease ABC activity
SPSF3K_RS07810	COG0561	phosphatase activity
SPSF3K_RS07815	COG1012	belongs to the aldehyde dehydrogenase family
SPSF3K_RS07820	COG1011	Hydrolase
SPSF3K_RS07830	COG2259	Doxx family
SPSF3K_RS07855	COG0667	Aldo Keto reductase
SPSF3K_RS07860	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SPSF3K_RS07870	COG0789	Transcriptional regulator
SPSF3K_RS07875	COG1063	alcohol dehydrogenase
SPSF3K_RS07880	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SPSF3K_RS07890	COG1028	Short-chain dehydrogenase reductase Sdr
SPSF3K_RS07895	COG0656	L-ascorbic acid biosynthetic process
SPSF3K_RS07910	COG1418	mRNA catabolic process
SPSF3K_RS07925	COG0481	GTPase activity
SPSF3K_RS07945	COG0647	UMP catabolic process
SPSF3K_RS07955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPSF3K_RS07965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPSF3K_RS07980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPSF3K_RS07985	COG3442	glutamine amidotransferase
SPSF3K_RS07990	COG0095	Lipoate-protein ligase
SPSF3K_RS08000	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPSF3K_RS08005	COG0022	dehydrogenase e1 component
SPSF3K_RS08005	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPSF3K_RS08010	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPSF3K_RS08015	COG0488	(ABC) transporter
SPSF3K_RS08035	COG3842	ATPase activity
SPSF3K_RS08050	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPSF3K_RS08055	COG3527	Alpha-acetolactate decarboxylase
SPSF3K_RS08060	COG0028	Belongs to the TPP enzyme family
SPSF3K_RS08065	COG0457	Tetratricopeptide repeat
SPSF3K_RS08070	COG0628	permease
SPSF3K_RS08075	COG1051	belongs to the nudix hydrolase family
SPSF3K_RS08080	COG2706	6-phosphogluconolactonase activity
SPSF3K_RS08090	COG1088	dTDP-glucose 4,6-dehydratase activity
SPSF3K_RS08100	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SPSF3K_RS08105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPSF3K_RS08120	COG2384	SAM-dependent methyltransferase
SPSF3K_RS08130	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPSF3K_RS08140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPSF3K_RS08145	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPSF3K_RS08145	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPSF3K_RS08150	COG0300	oxidoreductase activity
SPSF3K_RS08155	COG1234	tRNA 3'-trailer cleavage
SPSF3K_RS08165	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPSF3K_RS08170	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SPSF3K_RS08190	COG1054	Belongs to the UPF0176 family
SPSF3K_RS08210	COG0058	SHG alpha-glucan phosphorylase activity
SPSF3K_RS08215	COG1640	4-alpha-glucanotransferase
SPSF3K_RS08220	COG1609	Transcriptional regulator
SPSF3K_RS08230	COG1175	transmembrane transport
SPSF3K_RS08235	COG3833	ABC-type maltose transport systems, permease component
SPSF3K_RS08245	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPSF3K_RS08255	COG1696	Membrane protein involved in D-alanine export
SPSF3K_RS08270	COG0556	nucleotide-excision repair
SPSF3K_RS08280	COG1126	abc transporter atp-binding protein
SPSF3K_RS08290	COG0488	(ABC) transporter
SPSF3K_RS08310	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SPSF3K_RS08320	COG2309	aminopeptidase activity
SPSF3K_RS08325	COG0598	Magnesium transport protein CorA
SPSF3K_RS08330	COG1187	pseudouridine synthase activity
SPSF3K_RS08340	COG2814	Major facilitator Superfamily
SPSF3K_RS08350	COG0390	transport system, permease component
SPSF3K_RS08355	COG4619	ABC transporter
SPSF3K_RS08375	COG3620	sequence-specific DNA binding
SPSF3K_RS08380	COG1136	(ABC) transporter
SPSF3K_RS08395	COG0745	RESPONSE REGULATOR receiver
SPSF3K_RS08410	COG4989	oxidoreductase activity
SPSF3K_RS08425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPSF3K_RS08440	COG1316	TRANSCRIPTIONal
SPSF3K_RS08450	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SPSF3K_RS08460	COG0024	Methionine aminopeptidase
SPSF3K_RS08465	COG4109	DRTGG domain
SPSF3K_RS08485	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SPSF3K_RS08500	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPSF3K_RS08505	COG1956	GAF domain-containing protein
SPSF3K_RS08515	COG0572	uridine kinase
SPSF3K_RS08525	COG0726	polysaccharide deacetylase
SPSF3K_RS08545	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPSF3K_RS08550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPSF3K_RS08555	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPSF3K_RS08575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SPSF3K_RS08580	COG4122	O-methyltransferase activity
SPSF3K_RS08590	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SPSF3K_RS08605	COG4721	ABC-type cobalt transport system, permease component
SPSF3K_RS08615	COG2223	nitrite transmembrane transporter activity
SPSF3K_RS08620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPSF3K_RS08640	COG1187	pseudouridine synthase activity
SPSF3K_RS08645	COG0363	glucosamine-6-phosphate deaminase activity
SPSF3K_RS08670	COG2333	competence protein COMEC
SPSF3K_RS08670	COG0658	competence protein
SPSF3K_RS08680	COG0204	Acyl-transferase
SPSF3K_RS08685	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPSF3K_RS08700	COG0513	Belongs to the DEAD box helicase family
SPSF3K_RS08705	COG0561	phosphatase activity
SPSF3K_RS08720	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPSF3K_RS08740	COG0768	penicillin binding
SPSF3K_RS08745	COG2116	formate transmembrane transporter activity
SPSF3K_RS08765	COG0167	dihydroorotate dehydrogenase activity
SPSF3K_RS08775	COG2217	Heavy metal translocating P-type atpase
SPSF3K_RS08790	COG2755	lipolytic protein G-D-S-L family
SPSF3K_RS08800	COG0497	DNA recombination
SPSF3K_RS08810	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPSF3K_RS08830	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SPSF3K_RS08835	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPSF3K_RS08855	COG1126	abc transporter atp-binding protein
SPSF3K_RS08860	COG0765	amino acid transport
SPSF3K_RS08865	COG4703	Protein of unknown function (DUF1797)
SPSF3K_RS08870	COG0542	response to heat
SPSF3K_RS08890	COG3599	regulation of cell shape
SPSF3K_RS08905	COG1799	cell septum assembly
SPSF3K_RS08910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPSF3K_RS08935	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SPSF3K_RS08945	COG1217	gtp-binding protein TYPA
SPSF3K_RS08950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPSF3K_RS08955	COG1940	carbohydrate kinase activity
SPSF3K_RS08965	COG0783	Belongs to the Dps family
SPSF3K_RS08975	COG1132	(ABC) transporter
SPSF3K_RS08980	COG1132	(ABC) transporter
SPSF3K_RS08990	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SPSF3K_RS08995	COG4470	Protein conserved in bacteria
SPSF3K_RS09000	COG0737	Belongs to the 5'-nucleotidase family
SPSF3K_RS09005	COG1879	ABC-type sugar transport system periplasmic component
SPSF3K_RS09010	COG1172	Belongs to the binding-protein-dependent transport system permease family
SPSF3K_RS09015	COG1129	ABC transporter
SPSF3K_RS09020	COG1869	D-ribose catabolic process
SPSF3K_RS09025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPSF3K_RS09030	COG1609	Transcriptional regulator
SPSF3K_RS09035	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPSF3K_RS09040	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SPSF3K_RS09045	COG0742	ribosomal rna small subunit methyltransferase
SPSF3K_RS09050	COG2502	aspartate--ammonia ligase
SPSF3K_RS09055	COG0549	Belongs to the carbamate kinase family
SPSF3K_RS09060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPSF3K_RS09065	COG1288	antiporter activity
SPSF3K_RS09070	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SPSF3K_RS09075	COG0454	-acetyltransferase
SPSF3K_RS09080	COG2235	arginine
SPSF3K_RS09190	COG0110	maltose O-acetyltransferase activity
SPSF3K_RS09240	COG2211	Major facilitator Superfamily
SPSF3K_RS09250	COG1396	sequence-specific DNA binding
SPSF3K_RS09270	COG1914	H( )-stimulated, divalent metal cation uptake system
SPSF3K_RS09280	COG1136	(ABC) transporter
SPSF3K_RS09285	COG0435	Glutathione S-transferase
SPSF3K_RS09295	COG4152	abc transporter atp-binding protein
SPSF3K_RS09300	COG1668	transmembrane transport
SPSF3K_RS09305	COG0586	Pfam SNARE associated Golgi protein
SPSF3K_RS09315	COG0431	NADPH-dependent FMN reductase
SPSF3K_RS09315	COG1053	succinate dehydrogenase
SPSF3K_RS09315	COG3976	FMN-binding domain protein
SPSF3K_RS09320	COG0710	3-dehydroquinate dehydratase activity
SPSF3K_RS09335	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPSF3K_RS09340	COG2271	Major facilitator Superfamily
SPSF3K_RS09345	COG2271	Major facilitator Superfamily
SPSF3K_RS09350	COG1028	Short-chain dehydrogenase reductase Sdr
SPSF3K_RS09385	COG1960	acyl-CoA dehydrogenase activity
SPSF3K_RS09395	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPSF3K_RS09410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPSF3K_RS09415	COG1780	Probably involved in ribonucleotide reductase function
SPSF3K_RS09420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPSF3K_RS09440	COG2217	Heavy metal translocating P-type atpase
SPSF3K_RS09450	COG1573	uracil-dna glycosylase
SPSF3K_RS09465	COG1309	transcriptional regulator
SPSF3K_RS09515	COG2137	regulation of response to DNA damage stimulus
SPSF3K_RS09595	COG1040	competence protein
SPSF3K_RS09600	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPSF3K_RS09605	COG1739	Uncharacterized protein family UPF0029
SPSF3K_RS09615	COG1098	S1 RNA binding domain
SPSF3K_RS09625	COG2197	response regulator
SPSF3K_RS09630	COG4585	Histidine kinase
SPSF3K_RS09640	COG2815	serine threonine protein kinase
SPSF3K_RS09640	COG0515	serine threonine protein kinase
SPSF3K_RS09650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPSF3K_RS09650	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPSF3K_RS09655	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SPSF3K_RS09660	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPSF3K_RS09690	COG1854	S-ribosylhomocysteine lyase activity
SPSF3K_RS09700	COG0116	Belongs to the methyltransferase superfamily
SPSF3K_RS09715	COG4474	Belongs to the UPF0398 family
SPSF3K_RS09720	COG3331	DNA recombination
SPSF3K_RS09725	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPSF3K_RS09730	COG3579	cysteine-type endopeptidase activity
SPSF3K_RS09735	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SPSF3K_RS09740	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPSF3K_RS09745	COG1113	amino acid transport
SPSF3K_RS09750	COG0492	ferredoxin-NADP+ reductase activity
SPSF3K_RS09760	COG1126	abc transporter atp-binding protein
SPSF3K_RS09765	COG0765	amino acid transport
SPSF3K_RS09770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPSF3K_RS09775	COG0513	Belongs to the DEAD box helicase family
SPSF3K_RS09780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPSF3K_RS09785	COG0768	penicillin binding
SPSF3K_RS09795	COG0275	rRNA processing
SPSF3K_RS09800	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SPSF3K_RS09805	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SPSF3K_RS09815	COG1131	(ABC) transporter
SPSF3K_RS09845	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPSF3K_RS09855	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SPSF3K_RS09875	COG0751	glycine-tRNA ligase activity
SPSF3K_RS09880	COG0752	glycyl-tRNA synthetase alpha subunit
SPSF3K_RS09885	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPSF3K_RS09890	COG0656	L-ascorbic acid biosynthetic process
SPSF3K_RS09915	COG0561	phosphatase activity
SPSF3K_RS09925	COG2217	Heavy metal translocating P-type atpase
SPSF3K_RS09930	COG3682	Transcriptional regulator
SPSF3K_RS09950	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPSF3K_RS09955	COG0195	Participates in both transcription termination and antitermination
SPSF3K_RS09980	COG4473	ABC transporter
SPSF3K_RS09985	COG1131	(ABC) transporter
SPSF3K_RS09990	COG0537	adenosine 5'-monophosphoramidase activity
SPSF3K_RS10000	COG1316	TRANSCRIPTIONal
SPSF3K_RS10010	COG0802	atpase or kinase
SPSF3K_RS10015	COG2252	PERMEase
SPSF3K_RS10020	COG0561	phosphatase activity
SPSF3K_RS10030	COG3715	PTS system
SPSF3K_RS10035	COG3716	PTS system mannose fructose sorbose family IID component
SPSF3K_RS10050	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SPSF3K_RS10070	COG0439	Biotin carboxylase
SPSF3K_RS10075	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SPSF3K_RS10085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPSF3K_RS10090	COG1028	Short-chain dehydrogenase reductase Sdr
SPSF3K_RS10095	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPSF3K_RS10110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPSF3K_RS10115	COG1846	Transcriptional regulator
SPSF3K_RS10120	COG1024	Enoyl-CoA hydratase
SPSF3K_RS10140	COG1420	regulation of RNA biosynthetic process
SPSF3K_RS10155	COG0588	phosphoglycerate mutase activity
SPSF3K_RS10160	COG2848	UPF0210 protein
SPSF3K_RS10165	COG3830	Belongs to the UPF0237 family
SPSF3K_RS10180	COG2261	transglycosylase associated protein
SPSF3K_RS10205	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SPSF3K_RS10210	COG0574	Belongs to the PEP-utilizing enzyme family
SPSF3K_RS10210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPSF3K_RS10215	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SPSF3K_RS10220	COG0517	IMP dehydrogenase activity
SPSF3K_RS10270	COG3706	GGDEF domain
SPSF3K_RS10280	COG3655	Transcriptional regulator
SPSF3K_RS10295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPSF3K_RS10300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPSF3K_RS10400	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SPSF3K_RS10420	COG0201	protein transport
SPSF3K_RS10425	COG0200	Binds to the 23S rRNA
SPSF3K_RS10430	COG1841	ribosomal large subunit assembly
SPSF3K_RS10460	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SPSF3K_RS10470	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SPSF3K_RS10485	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SPSF3K_RS10490	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SPSF3K_RS10505	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SPSF3K_RS10510	COG0089	rRNA binding
SPSF3K_RS10515	COG0088	Forms part of the polypeptide exit tunnel
SPSF3K_RS10525	COG0051	transcription antitermination factor activity, RNA binding
SPSF3K_RS10530	COG0534	Mate efflux family protein
SPSF3K_RS10540	COG1012	belongs to the aldehyde dehydrogenase family
SPSF3K_RS10540	COG1454	alcohol dehydrogenase
SPSF3K_RS10555	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPSF3K_RS10560	COG2255	four-way junction helicase activity
SPSF3K_RS10570	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPSF3K_RS10580	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPSF3K_RS10585	COG0151	Belongs to the GarS family
SPSF3K_RS10605	COG0138	bifunctional purine biosynthesis protein purh
SPSF3K_RS10610	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPSF3K_RS10615	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SPSF3K_RS10625	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPSF3K_RS10630	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SPSF3K_RS10635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPSF3K_RS10640	COG0416	fatty acid biosynthetic process
SPSF3K_RS10645	COG1381	Involved in DNA repair and RecF pathway recombination
SPSF3K_RS10650	COG0436	Aminotransferase
SPSF3K_RS10660	COG3942	CHAP domain
SPSF3K_RS10845	COG0531	amino acid
SPSF3K_RS10850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPSF3K_RS10875	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPSF3K_RS10880	COG2244	polysaccharide biosynthetic process
SPSF3K_RS10885	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPSF3K_RS10890	COG0193	aminoacyl-tRNA hydrolase activity
SPSF3K_RS10895	COG0012	GTP binding
SPSF3K_RS10910	COG0592	DNA-directed DNA polymerase activity
SPSF3K_RS10915	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SPSF3K_RS10950	COG2184	nucleotidyltransferase activity
SPSF3K_RS10990	COG4886	Leucine-rich repeat (LRR) protein
SPSF3K_RS10990	COG4932	domain protein
SPSF3K_RS11030	COG2184	nucleotidyltransferase activity
SPSF3K_RS11070	COG4932	domain protein
SPSF3K_RS11070	COG4886	Leucine-rich repeat (LRR) protein