locus-tag	class	description
E8M05_RS00010	COG0592	DNA-directed DNA polymerase activity
E8M05_RS00015	COG1597	lipid kinase activity
E8M05_RS00025	COG0012	GTP binding
E8M05_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E8M05_RS00050	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E8M05_RS00065	COG2946	Replication initiation factor
E8M05_RS00095	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E8M05_RS00125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E8M05_RS00310	COG1792	Involved in formation and maintenance of cell shape
E8M05_RS00320	COG3942	CHAP domain
E8M05_RS00330	COG0436	Aminotransferase
E8M05_RS00340	COG0416	fatty acid biosynthetic process
E8M05_RS00345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E8M05_RS00350	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E8M05_RS00365	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E8M05_RS00370	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E8M05_RS00385	COG0151	Belongs to the GarS family
E8M05_RS00390	COG1683	Conserved Protein
E8M05_RS00395	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E8M05_RS00410	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E8M05_RS00425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E8M05_RS00470	COG0051	transcription antitermination factor activity, RNA binding
E8M05_RS00480	COG0088	Forms part of the polypeptide exit tunnel
E8M05_RS00485	COG0089	rRNA binding
E8M05_RS00515	COG0255	Belongs to the universal ribosomal protein uL29 family
E8M05_RS00530	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E8M05_RS00540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E8M05_RS00560	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E8M05_RS00565	COG1841	ribosomal large subunit assembly
E8M05_RS00575	COG0201	protein transport
E8M05_RS00595	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E8M05_RS00600	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E8M05_RS00605	COG0202	RNA polymerase activity
E8M05_RS00610	COG0203	ribosomal protein L17
E8M05_RS00700	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E8M05_RS00710	COG1121	(ABC) transporter
E8M05_RS00715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E8M05_RS00815	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E8M05_RS00825	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E8M05_RS00830	COG1459	type II secretion system
E8M05_RS00835	COG4537	Required for transformation and DNA binding
E8M05_RS00885	COG1266	CAAX protease self-immunity
E8M05_RS00890	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E8M05_RS00895	COG1363	Peptidase, m42
E8M05_RS00910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E8M05_RS00915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E8M05_RS00925	COG0561	phosphatase activity
E8M05_RS00935	COG4585	Histidine kinase
E8M05_RS00940	COG2197	response regulator
E8M05_RS00960	COG3715	PTS system
E8M05_RS00965	COG3716	PTS system mannose fructose sorbose family IID component
E8M05_RS00975	COG4120	Belongs to the binding-protein-dependent transport system permease family
E8M05_RS00980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E8M05_RS00995	COG1396	sequence-specific DNA binding
E8M05_RS01010	COG0564	pseudouridine synthase activity
E8M05_RS01020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E8M05_RS01045	COG4667	esterase of the alpha-beta hydrolase superfamily
E8M05_RS01055	COG2017	converts alpha-aldose to the beta-anomer
E8M05_RS01080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E8M05_RS01100	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E8M05_RS01105	COG1609	Transcriptional regulator
E8M05_RS01110	COG1263	PTS System
E8M05_RS01110	COG2190	(PTS) system
E8M05_RS01110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E8M05_RS01125	COG1363	Peptidase, m42
E8M05_RS01135	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E8M05_RS01140	COG1447	Phosphotransferase system cellobiose-specific component IIA
E8M05_RS01145	COG2723	6-phospho-beta-galactosidase activity
E8M05_RS01150	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E8M05_RS01155	COG2188	Transcriptional regulator
E8M05_RS01160	COG1482	cell wall glycoprotein biosynthetic process
E8M05_RS01175	COG1653	transport
E8M05_RS01180	COG1175	transmembrane transport
E8M05_RS01185	COG0395	ABC-type sugar transport system, permease component
E8M05_RS01200	COG2188	Transcriptional regulator
E8M05_RS01205	COG1940	carbohydrate kinase activity
E8M05_RS01235	COG3842	ATPase activity
E8M05_RS01275	COG3775	system Galactitol-specific IIC component
E8M05_RS01285	COG3711	transcriptional antiterminator
E8M05_RS01290	COG2723	6-phospho-beta-galactosidase activity
E8M05_RS01295	COG1447	Phosphotransferase system cellobiose-specific component IIA
E8M05_RS01300	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E8M05_RS01300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E8M05_RS01305	COG3867	Arabinogalactan endo-beta-1,4-galactanase
E8M05_RS01310	COG2207	Transcriptional regulator
E8M05_RS01315	COG3345	alpha-galactosidase
E8M05_RS01320	COG1653	transport
E8M05_RS01325	COG1175	transmembrane transport
E8M05_RS01330	COG0395	ABC-type sugar transport system, permease component
E8M05_RS01335	COG0366	Alpha amylase catalytic
E8M05_RS01340	COG0366	Alpha amylase catalytic
E8M05_RS01345	COG1609	Transcriptional regulator
E8M05_RS01350	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E8M05_RS01355	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
E8M05_RS01360	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E8M05_RS01370	COG1862	Preprotein translocase
E8M05_RS01375	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E8M05_RS01380	COG4589	Belongs to the CDS family
E8M05_RS01415	COG0242	peptide deformylase activity
E8M05_RS01435	COG0346	lactoylglutathione lyase activity
E8M05_RS01440	COG0561	phosphatase activity
E8M05_RS01450	COG1454	alcohol dehydrogenase
E8M05_RS01450	COG1012	belongs to the aldehyde dehydrogenase family
E8M05_RS01465	COG1185	polyribonucleotide nucleotidyltransferase activity
E8M05_RS01475	COG1045	serine acetyltransferase
E8M05_RS01485	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
E8M05_RS01510	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E8M05_RS01590	COG3830	Belongs to the UPF0237 family
E8M05_RS01595	COG2848	UPF0210 protein
E8M05_RS01605	COG0588	phosphoglycerate mutase activity
E8M05_RS01615	COG1705	Flagellar rod assembly protein muramidase FlgJ
E8M05_RS01645	COG0352	thiamine-phosphate diphosphorylase activity
E8M05_RS01645	COG0351	phosphomethylpyrimidine kinase
E8M05_RS01660	COG0668	transmembrane transport
E8M05_RS01675	COG0504	CTP synthase activity
E8M05_RS01690	COG0191	fructose-bisphosphate aldolase activity
E8M05_RS01705	COG1609	Transcriptional regulator
E8M05_RS01715	COG1621	beta-fructofuranosidase activity
E8M05_RS01725	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E8M05_RS01735	COG1461	Dihydroxyacetone kinase
E8M05_RS01740	COG0129	dihydroxy-acid dehydratase activity
E8M05_RS01745	COG0028	Belongs to the TPP enzyme family
E8M05_RS01750	COG0440	acetolactate synthase activity
E8M05_RS01755	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E8M05_RS01760	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E8M05_RS01780	COG1126	abc transporter atp-binding protein
E8M05_RS01785	COG0765	amino acid transport
E8M05_RS01805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E8M05_RS01815	COG0719	Fe-S assembly protein
E8M05_RS01820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E8M05_RS01830	COG0719	Fe-S assembly protein
E8M05_RS01835	COG1686	Belongs to the peptidase S11 family
E8M05_RS01840	COG4166	transmembrane transport
E8M05_RS01845	COG0601	transmembrane transport
E8M05_RS01850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E8M05_RS01855	COG0444	Belongs to the ABC transporter superfamily
E8M05_RS01905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E8M05_RS01910	COG1024	Enoyl-CoA hydratase
E8M05_RS01920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E8M05_RS01930	COG2070	2-Nitropropane dioxygenase
E8M05_RS01935	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E8M05_RS01940	COG1028	Short-chain dehydrogenase reductase Sdr
E8M05_RS01945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E8M05_RS01960	COG0439	Biotin carboxylase
E8M05_RS01975	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E8M05_RS01985	COG3716	PTS system mannose fructose sorbose family IID component
E8M05_RS01990	COG3715	PTS system
E8M05_RS02000	COG0561	phosphatase activity
E8M05_RS02015	COG2252	PERMEase
E8M05_RS02020	COG0802	atpase or kinase
E8M05_RS02030	COG1316	TRANSCRIPTIONal
E8M05_RS02045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E8M05_RS02045	COG1263	PTS System
E8M05_RS02055	COG2723	6-phospho-beta-galactosidase activity
E8M05_RS02075	COG0537	adenosine 5'-monophosphoramidase activity
E8M05_RS02080	COG1131	(ABC) transporter
E8M05_RS02085	COG4473	ABC transporter
E8M05_RS02095	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E8M05_RS02115	COG0195	Participates in both transcription termination and antitermination
E8M05_RS02120	COG2740	Nucleic-acid-binding protein implicated in transcription termination
E8M05_RS02130	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E8M05_RS02135	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E8M05_RS02165	COG2860	membrane
E8M05_RS02170	COG0561	phosphatase activity
E8M05_RS02205	COG2188	Transcriptional regulator
E8M05_RS02210	COG2222	sugar isomerase
E8M05_RS02230	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E8M05_RS02230	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E8M05_RS02240	COG3716	PTS system mannose fructose sorbose family IID component
E8M05_RS02245	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E8M05_RS02245	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E8M05_RS02270	COG3711	transcriptional antiterminator
E8M05_RS02270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E8M05_RS02280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E8M05_RS02280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E8M05_RS02280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E8M05_RS02285	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E8M05_RS02295	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E8M05_RS02315	COG1131	(ABC) transporter
E8M05_RS02325	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E8M05_RS02345	COG0768	penicillin binding
E8M05_RS02350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E8M05_RS02355	COG0513	Belongs to the DEAD box helicase family
E8M05_RS02370	COG1126	abc transporter atp-binding protein
E8M05_RS02385	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E8M05_RS02390	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E8M05_RS02395	COG3579	cysteine-type endopeptidase activity
E8M05_RS02405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E8M05_RS02410	COG3331	DNA recombination
E8M05_RS02420	COG3599	regulation of cell shape
E8M05_RS02430	COG0116	Belongs to the methyltransferase superfamily
E8M05_RS02445	COG1854	S-ribosylhomocysteine lyase activity
E8M05_RS02465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E8M05_RS02470	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E8M05_RS02475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E8M05_RS02475	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E8M05_RS02495	COG4585	Histidine kinase
E8M05_RS02500	COG2197	response regulator
E8M05_RS02510	COG1098	S1 RNA binding domain
E8M05_RS02520	COG1739	Uncharacterized protein family UPF0029
E8M05_RS02525	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
E8M05_RS02530	COG1040	competence protein
E8M05_RS02605	COG3557	Belongs to the UPF0374 family
E8M05_RS02610	COG2137	regulation of response to DNA damage stimulus
E8M05_RS02620	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E8M05_RS02640	COG1428	Deoxynucleoside kinase
E8M05_RS02695	COG1309	transcriptional regulator
E8M05_RS02720	COG0742	ribosomal rna small subunit methyltransferase
E8M05_RS02725	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E8M05_RS02730	COG3480	Lon protease (S16) C-terminal proteolytic domain
E8M05_RS02745	COG0737	Belongs to the 5'-nucleotidase family
E8M05_RS02750	COG4470	Protein conserved in bacteria
E8M05_RS02765	COG1132	(ABC) transporter
E8M05_RS02770	COG1132	(ABC) transporter
E8M05_RS02775	COG1131	(ABC) transporter
E8M05_RS02785	COG4585	Histidine kinase
E8M05_RS02790	COG2197	response regulator
E8M05_RS02810	COG2186	Transcriptional regulator
E8M05_RS02865	COG2205	protein histidine kinase activity
E8M05_RS02870	COG0745	RESPONSE REGULATOR receiver
E8M05_RS02890	COG1914	H( )-stimulated, divalent metal cation uptake system
E8M05_RS02900	COG0783	Belongs to the Dps family
E8M05_RS02910	COG1940	carbohydrate kinase activity
E8M05_RS02915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E8M05_RS02925	COG1217	gtp-binding protein TYPA
E8M05_RS02960	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E8M05_RS02965	COG1799	cell septum assembly
E8M05_RS02980	COG3599	regulation of cell shape
E8M05_RS03005	COG0542	response to heat
E8M05_RS03020	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E8M05_RS03025	COG4703	Protein of unknown function (DUF1797)
E8M05_RS03030	COG0765	amino acid transport
E8M05_RS03035	COG1126	abc transporter atp-binding protein
E8M05_RS03060	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E8M05_RS03080	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E8M05_RS03085	COG1438	arginine binding
E8M05_RS03090	COG0497	DNA recombination
E8M05_RS03095	COG1307	EDD domain protein, DegV family
E8M05_RS03100	COG2755	lipolytic protein G-D-S-L family
E8M05_RS03105	COG4698	Protein conserved in bacteria
E8M05_RS03125	COG3104	oligopeptide transport
E8M05_RS03130	COG0167	dihydroorotate dehydrogenase activity
E8M05_RS03135	COG0604	alcohol dehydrogenase
E8M05_RS03135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E8M05_RS03135	COG3321	synthase
E8M05_RS03135	COG4221	oxidoreductase activity
E8M05_RS03140	COG0640	Transcriptional regulator
E8M05_RS03145	COG2217	Heavy metal translocating P-type atpase
E8M05_RS03150	COG2076	Multidrug Resistance protein
E8M05_RS03165	COG1827	regulation of RNA biosynthetic process
E8M05_RS03175	COG0768	penicillin binding
E8M05_RS03180	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E8M05_RS03185	COG1181	Belongs to the D-alanine--D-alanine ligase family
E8M05_RS03195	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E8M05_RS03215	COG0513	Belongs to the DEAD box helicase family
E8M05_RS03245	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E8M05_RS03250	COG0204	Acyl-transferase
E8M05_RS03255	COG1555	photosystem II stabilization
E8M05_RS03255	COG1596	polysaccharide export
E8M05_RS03260	COG2333	competence protein COMEC
E8M05_RS03260	COG0658	competence protein
E8M05_RS03265	COG1466	dna polymerase III delta subunit
E8M05_RS03270	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E8M05_RS03275	COG0217	transcriptional regulatory protein
E8M05_RS03290	COG0363	glucosamine-6-phosphate deaminase activity
E8M05_RS03295	COG1187	pseudouridine synthase activity
E8M05_RS03315	COG0546	phosphoglycolate phosphatase activity
E8M05_RS03320	COG4122	O-methyltransferase activity
E8M05_RS03330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E8M05_RS03340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E8M05_RS03345	COG0436	Aminotransferase
E8M05_RS03355	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E8M05_RS03360	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E8M05_RS03365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E8M05_RS03370	COG2249	NAD(P)H dehydrogenase (quinone) activity
E8M05_RS03375	COG1476	TRANSCRIPTIONal
E8M05_RS03385	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E8M05_RS03385	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E8M05_RS03390	COG0307	riboflavin synthase, alpha
E8M05_RS03395	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E8M05_RS03395	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E8M05_RS03415	COG3859	Proton-coupled thiamine transporter YuaJ
E8M05_RS03420	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E8M05_RS03425	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E8M05_RS03430	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E8M05_RS03435	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E8M05_RS03440	COG0372	Belongs to the citrate synthase family
E8M05_RS03460	COG1609	Transcriptional regulator
E8M05_RS03465	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E8M05_RS03470	COG0251	oxidation-reduction process
E8M05_RS03480	COG1309	transcriptional regulator
E8M05_RS03525	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E8M05_RS03530	COG1660	Displays ATPase and GTPase activities
E8M05_RS03575	COG1705	Flagellar rod assembly protein muramidase FlgJ
E8M05_RS03575	COG1388	LysM domain
E8M05_RS03585	COG0577	efflux transmembrane transporter activity
E8M05_RS03590	COG1136	(ABC) transporter
E8M05_RS03595	COG0577	efflux transmembrane transporter activity
E8M05_RS03600	COG0745	RESPONSE REGULATOR receiver
E8M05_RS03605	COG5002	protein histidine kinase activity
E8M05_RS03670	COG4974	Belongs to the 'phage' integrase family
E8M05_RS03680	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E8M05_RS03705	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E8M05_RS03720	COG0513	Belongs to the DEAD box helicase family
E8M05_RS03740	COG3326	Membrane
E8M05_RS03745	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E8M05_RS03750	COG0066	3-isopropylmalate dehydratase activity
E8M05_RS03755	COG1956	GAF domain-containing protein
E8M05_RS03760	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E8M05_RS03770	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E8M05_RS03770	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E8M05_RS03775	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E8M05_RS03790	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E8M05_RS03800	COG4109	DRTGG domain
E8M05_RS03805	COG0024	Methionine aminopeptidase
E8M05_RS03815	COG2246	polysaccharide biosynthetic process
E8M05_RS03820	COG4708	membrane
E8M05_RS03825	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E8M05_RS03830	COG1597	lipid kinase activity
E8M05_RS03860	COG0356	it plays a direct role in the translocation of protons across the membrane
E8M05_RS03865	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E8M05_RS03900	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E8M05_RS03915	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E8M05_RS03930	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
E8M05_RS03935	COG1074	ATP-dependent DNA helicase activity
E8M05_RS03940	COG1917	Cupin 2, conserved barrel domain protein
E8M05_RS03940	COG4977	sequence-specific DNA binding
E8M05_RS03945	COG0366	Alpha amylase catalytic
E8M05_RS03960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E8M05_RS03960	COG1263	PTS System
E8M05_RS03965	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E8M05_RS03990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E8M05_RS04005	COG0300	oxidoreductase activity
E8M05_RS04010	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E8M05_RS04010	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E8M05_RS04015	COG0281	malic enzyme
E8M05_RS04025	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
E8M05_RS04175	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E8M05_RS04180	COG2384	SAM-dependent methyltransferase
E8M05_RS04190	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E8M05_RS04200	COG1088	dTDP-glucose 4,6-dehydratase activity
E8M05_RS04210	COG1051	belongs to the nudix hydrolase family
E8M05_RS04215	COG0628	permease
E8M05_RS04220	COG0457	Tetratricopeptide repeat
E8M05_RS04245	COG2205	protein histidine kinase activity
E8M05_RS04250	COG0745	RESPONSE REGULATOR receiver
E8M05_RS04270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E8M05_RS04275	COG0028	Belongs to the TPP enzyme family
E8M05_RS04280	COG3527	Alpha-acetolactate decarboxylase
E8M05_RS04300	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E8M05_RS04310	COG3716	PTS system mannose fructose sorbose family IID component
E8M05_RS04320	COG0366	Alpha amylase catalytic
E8M05_RS04330	COG0531	amino acid
E8M05_RS04335	COG1293	RNA-binding protein homologous to eukaryotic snRNP
E8M05_RS04345	COG4120	Belongs to the binding-protein-dependent transport system permease family
E8M05_RS04350	COG3842	ATPase activity
E8M05_RS04365	COG0488	(ABC) transporter
E8M05_RS04375	COG1132	(ABC) transporter
E8M05_RS04380	COG1132	(ABC) transporter
E8M05_RS04390	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
E8M05_RS04395	COG2190	(PTS) system
E8M05_RS04395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E8M05_RS04395	COG1263	PTS System
E8M05_RS04400	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E8M05_RS04405	COG0508	dehydrogenase complex catalyzes the overall conversion of
E8M05_RS04405	COG0022	dehydrogenase e1 component
E8M05_RS04415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E8M05_RS04440	COG0095	Lipoate-protein ligase
E8M05_RS04455	COG0583	DNA-binding transcription factor activity
E8M05_RS04465	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E8M05_RS04490	COG2814	Major facilitator Superfamily
E8M05_RS04515	COG1937	Protein conserved in bacteria
E8M05_RS04525	COG0446	pyridine nucleotide-disulphide oxidoreductase
E8M05_RS04535	COG1418	mRNA catabolic process
E8M05_RS04565	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E8M05_RS04575	COG0583	DNA-binding transcription factor activity
E8M05_RS04585	COG1028	Short-chain dehydrogenase reductase Sdr
E8M05_RS04600	COG0789	Transcriptional regulator
E8M05_RS04605	COG0656	L-ascorbic acid biosynthetic process
E8M05_RS04635	COG1136	(ABC) transporter
E8M05_RS04640	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E8M05_RS04645	COG1011	Hydrolase
E8M05_RS04655	COG0583	DNA-binding transcription factor activity
E8M05_RS04660	COG2855	membrane
E8M05_RS04665	COG1012	belongs to the aldehyde dehydrogenase family
E8M05_RS04675	COG0322	excinuclease ABC activity
E8M05_RS04700	COG1573	uracil-dna glycosylase
E8M05_RS04720	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E8M05_RS04725	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E8M05_RS04755	COG1316	TRANSCRIPTIONal
E8M05_RS04775	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E8M05_RS04780	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E8M05_RS04795	COG0438	transferase activity, transferring glycosyl groups
E8M05_RS04805	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E8M05_RS04825	COG0371	Dehydrogenase
E8M05_RS04830	COG1213	nucleotidyl transferase
E8M05_RS04840	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E8M05_RS04845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E8M05_RS04850	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E8M05_RS04855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E8M05_RS04855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E8M05_RS04855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E8M05_RS04860	COG0383	alpha-mannosidase activity
E8M05_RS04880	COG0167	dihydroorotate dehydrogenase activity
E8M05_RS04885	COG0284	orotidine-5'-phosphate decarboxylase activity
E8M05_RS04900	COG1881	PFAM PEBP family protein
E8M05_RS04920	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E8M05_RS04925	COG0187	DNA topoisomerase II activity
E8M05_RS04930	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E8M05_RS04935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E8M05_RS04955	COG0539	negative regulation of cytoplasmic translation
E8M05_RS04965	COG1346	cytolysis
E8M05_RS04970	COG1380	Effector of murein hydrolase LrgA
E8M05_RS04990	COG1131	(ABC) transporter
E8M05_RS04995	COG1725	Transcriptional regulator
E8M05_RS05005	COG0205	6-phosphofructokinase activity
E8M05_RS05010	COG0469	pyruvate kinase activity
E8M05_RS05025	COG2824	Alkylphosphonate utilization operon protein PhnA
E8M05_RS05030	COG0765	amino acid transport
E8M05_RS05035	COG1126	abc transporter atp-binding protein
E8M05_RS05045	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E8M05_RS05050	COG1115	amino acid carrier protein
E8M05_RS05055	COG2723	6-phospho-beta-galactosidase activity
E8M05_RS05065	COG0406	alpha-ribazole phosphatase activity
E8M05_RS05075	COG0628	permease
E8M05_RS05080	COG1442	glycosyl transferase family 8
E8M05_RS05090	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E8M05_RS05100	COG1104	cysteine desulfurase activity
E8M05_RS05115	COG2357	RelA SpoT domain protein
E8M05_RS05125	COG0564	pseudouridine synthase activity
E8M05_RS05130	COG0280	phosphate acetyltransferase
E8M05_RS05135	COG4221	oxidoreductase activity
E8M05_RS05145	COG0561	phosphatase activity
E8M05_RS05155	COG0477	Major facilitator Superfamily
E8M05_RS05160	COG2723	6-phospho-beta-galactosidase activity
E8M05_RS05165	COG1136	(ABC) transporter
E8M05_RS05170	COG0577	efflux transmembrane transporter activity
E8M05_RS05175	COG0516	GMP reductase activity
E8M05_RS05195	COG2233	PERMEase
E8M05_RS05215	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E8M05_RS05220	COG2890	protein-(glutamine-N5) methyltransferase activity
E8M05_RS05225	COG0009	L-threonylcarbamoyladenylate synthase
E8M05_RS05245	COG1132	(ABC) transporter
E8M05_RS05250	COG1132	(ABC) transporter
E8M05_RS05265	COG3711	transcriptional antiterminator
E8M05_RS05270	COG1447	Phosphotransferase system cellobiose-specific component IIA
E8M05_RS05280	COG2723	6-phospho-beta-galactosidase activity
E8M05_RS05285	COG0519	Catalyzes the synthesis of GMP from XMP
E8M05_RS05285	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E8M05_RS05330	COG2376	Dihydroxyacetone kinase
E8M05_RS05335	COG1309	transcriptional regulator
E8M05_RS05340	COG2376	Dihydroxyacetone kinase
E8M05_RS05345	COG1461	Dihydroxyacetone kinase
E8M05_RS05350	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
E8M05_RS05355	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E8M05_RS05375	COG0210	DNA helicase
E8M05_RS05380	COG2188	Transcriptional regulator
E8M05_RS05385	COG1959	2 iron, 2 sulfur cluster binding
E8M05_RS05390	COG1063	alcohol dehydrogenase
E8M05_RS05395	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
E8M05_RS05400	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E8M05_RS05405	COG4974	Belongs to the 'phage' integrase family
E8M05_RS05415	COG5002	protein histidine kinase activity
E8M05_RS05420	COG0745	RESPONSE REGULATOR receiver
E8M05_RS05425	COG0577	efflux transmembrane transporter activity
E8M05_RS05430	COG1136	(ABC) transporter
E8M05_RS05440	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
E8M05_RS05460	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E8M05_RS05465	COG0758	DNA mediated transformation
E8M05_RS05470	COG0110	maltose O-acetyltransferase activity
E8M05_RS05475	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E8M05_RS05480	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E8M05_RS05495	COG5002	protein histidine kinase activity
E8M05_RS05500	COG0745	RESPONSE REGULATOR receiver
E8M05_RS05510	COG1136	(ABC) transporter
E8M05_RS05540	COG1131	(ABC) transporter
E8M05_RS05545	COG2188	Transcriptional regulator
E8M05_RS05570	COG1028	Short-chain dehydrogenase reductase Sdr
E8M05_RS05585	COG1904	glucuronate isomerase
E8M05_RS05590	COG0800	Aldolase
E8M05_RS05600	COG3250	beta-galactosidase activity
E8M05_RS05610	COG2211	Major facilitator Superfamily
E8M05_RS05615	COG0488	(ABC) transporter
E8M05_RS05630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E8M05_RS05635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E8M05_RS05640	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E8M05_RS05645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E8M05_RS05670	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E8M05_RS05675	COG4684	Psort location CytoplasmicMembrane, score
E8M05_RS05680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E8M05_RS05710	COG1136	(ABC) transporter
E8M05_RS05730	COG0745	RESPONSE REGULATOR receiver
E8M05_RS05735	COG5002	protein histidine kinase activity
E8M05_RS05770	COG1131	(ABC) transporter
E8M05_RS05795	COG0346	lactoylglutathione lyase activity
E8M05_RS05800	COG3764	Sortase (surface protein transpeptidase)
E8M05_RS05830	COG1079	Belongs to the binding-protein-dependent transport system permease family
E8M05_RS05835	COG4603	Belongs to the binding-protein-dependent transport system permease family
E8M05_RS05840	COG3845	ABC transporter
E8M05_RS05845	COG1744	ABC transporter substrate-binding protein PnrA-like
E8M05_RS05850	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E8M05_RS05855	COG2813	Specifically methylates the guanine in position
E8M05_RS05860	COG1072	(Pantothenic acid kinase))
E8M05_RS05870	COG5002	protein histidine kinase activity
E8M05_RS05875	COG0745	RESPONSE REGULATOR receiver
E8M05_RS05885	COG0704	Plays a role in the regulation of phosphate uptake
E8M05_RS05890	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E8M05_RS05895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E8M05_RS05900	COG0581	inorganic phosphate transmembrane transporter activity
E8M05_RS05905	COG0573	inorganic phosphate transmembrane transporter activity
E8M05_RS05925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E8M05_RS05945	COG0519	Catalyzes the synthesis of GMP from XMP
E8M05_RS05950	COG0483	inositol monophosphate 1-phosphatase activity
E8M05_RS05955	COG4476	Belongs to the UPF0223 family
E8M05_RS05960	COG1393	Belongs to the ArsC family
E8M05_RS05965	COG0196	riboflavin kinase activity
E8M05_RS05970	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E8M05_RS06000	COG1129	ABC transporter
E8M05_RS06015	COG1132	(ABC) transporter
E8M05_RS06020	COG4988	ABC transporter
E8M05_RS06065	COG1136	(ABC) transporter
E8M05_RS06065	COG0577	efflux transmembrane transporter activity
E8M05_RS06090	COG0745	RESPONSE REGULATOR receiver
E8M05_RS06140	COG1115	amino acid carrier protein
E8M05_RS06170	COG0561	phosphatase activity
E8M05_RS06175	COG2723	6-phospho-beta-galactosidase activity
E8M05_RS06185	COG0561	phosphatase activity
E8M05_RS06190	COG0561	phosphatase activity
E8M05_RS06195	COG2723	6-phospho-beta-galactosidase activity
E8M05_RS06210	COG1737	Transcriptional regulator
E8M05_RS06235	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E8M05_RS06245	COG1447	Phosphotransferase system cellobiose-specific component IIA
E8M05_RS06250	COG3711	transcriptional antiterminator
E8M05_RS06250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E8M05_RS06255	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E8M05_RS06270	COG2723	6-phospho-beta-galactosidase activity
E8M05_RS06300	COG2272	Belongs to the type-B carboxylesterase lipase family
E8M05_RS06305	COG2190	(PTS) system
E8M05_RS06305	COG1263	PTS System
E8M05_RS06305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E8M05_RS06310	COG3711	transcriptional antiterminator
E8M05_RS06325	COG1177	transmembrane transport
E8M05_RS06330	COG1176	ABC-type spermidine putrescine transport system, permease component I
E8M05_RS06340	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E8M05_RS06365	COG0285	dihydrofolate synthase activity
E8M05_RS06375	COG2962	Rard protein
E8M05_RS06390	COG0726	polysaccharide deacetylase
E8M05_RS06440	COG2378	regulation of single-species biofilm formation
E8M05_RS06445	COG0833	amino acid
E8M05_RS06465	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E8M05_RS06470	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E8M05_RS06475	COG3425	synthase
E8M05_RS06490	COG1272	protein, Hemolysin III
E8M05_RS06495	COG1304	FMN binding
E8M05_RS06510	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E8M05_RS06515	COG1126	abc transporter atp-binding protein
E8M05_RS06520	COG0765	amino acid transport
E8M05_RS06525	COG0765	amino acid transport
E8M05_RS06530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E8M05_RS06545	COG0583	DNA-binding transcription factor activity
E8M05_RS06550	COG0656	L-ascorbic acid biosynthetic process
E8M05_RS06560	COG0745	RESPONSE REGULATOR receiver
E8M05_RS06565	COG2357	RelA SpoT domain protein
E8M05_RS06600	COG1132	(ABC) transporter
E8M05_RS06615	COG0242	peptide deformylase activity
E8M05_RS06620	COG0456	acetyltransferase
E8M05_RS06625	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E8M05_RS06640	COG0720	synthase
E8M05_RS06645	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E8M05_RS06650	COG1132	(ABC) transporter
E8M05_RS06660	COG0488	(ABC) transporter
E8M05_RS06665	COG0617	tRNA 3'-terminal CCA addition
E8M05_RS06685	COG1705	Flagellar rod assembly protein muramidase FlgJ
E8M05_RS06685	COG1388	LysM domain
E8M05_RS06690	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E8M05_RS06700	COG0667	Aldo Keto reductase
E8M05_RS06710	COG0646	methionine synthase
E8M05_RS06710	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E8M05_RS06715	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E8M05_RS06720	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E8M05_RS06720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E8M05_RS06720	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E8M05_RS06725	COG1105	Belongs to the carbohydrate kinase PfkB family
E8M05_RS06730	COG1349	DNA-binding transcription factor activity
E8M05_RS06735	COG0492	ferredoxin-NADP+ reductase activity
E8M05_RS06740	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
E8M05_RS06745	COG0336	Belongs to the RNA methyltransferase TrmD family
E8M05_RS06750	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E8M05_RS06765	COG1837	Belongs to the UPF0109 family
E8M05_RS06795	COG0577	efflux transmembrane transporter activity
E8M05_RS06800	COG1136	(ABC) transporter
E8M05_RS06815	COG0505	Belongs to the CarA family
E8M05_RS06820	COG0540	Belongs to the ATCase OTCase family
E8M05_RS06830	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E8M05_RS06835	COG0564	pseudouridine synthase activity
E8M05_RS06845	COG0583	DNA-binding transcription factor activity
E8M05_RS06850	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E8M05_RS06875	COG0301	tRNA thio-modification
E8M05_RS06880	COG1104	cysteine desulfurase activity
E8M05_RS06890	COG0285	dihydrofolate synthase activity
E8M05_RS06905	COG0287	Prephenate dehydrogenase
E8M05_RS06915	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E8M05_RS06920	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E8M05_RS06930	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E8M05_RS06935	COG1368	sulfuric ester hydrolase activity
E8M05_RS06945	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E8M05_RS06950	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E8M05_RS06955	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E8M05_RS06980	COG2195	Cleaves the N-terminal amino acid of tripeptides
E8M05_RS06995	COG3942	CHAP domain
E8M05_RS07005	COG0463	Glycosyl transferase, family 2
E8M05_RS07015	COG1368	sulfuric ester hydrolase activity
E8M05_RS07025	COG1216	Glycosyl transferase, family 2
E8M05_RS07025	COG1442	glycosyl transferase family 8
E8M05_RS07040	COG0463	Glycosyl transferase, family 2
E8M05_RS07050	COG1091	dTDP-4-dehydrorhamnose reductase activity
E8M05_RS07060	COG2151	metal-sulfur cluster biosynthetic enzyme
E8M05_RS07065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E8M05_RS07070	COG0358	DNA primase activity
E8M05_RS07075	COG1970	mechanosensitive ion channel activity
E8M05_RS07085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E8M05_RS07090	COG0436	Aminotransferase
E8M05_RS07105	COG0058	SHG alpha-glucan phosphorylase activity
E8M05_RS07110	COG1640	4-alpha-glucanotransferase
E8M05_RS07115	COG1609	Transcriptional regulator
E8M05_RS07125	COG1175	transmembrane transport
E8M05_RS07130	COG3833	ABC-type maltose transport systems, permease component
E8M05_RS07135	COG2816	NAD+ diphosphatase activity
E8M05_RS07140	COG0556	nucleotide-excision repair
E8M05_RS07145	COG0765	amino acid transport
E8M05_RS07150	COG1126	abc transporter atp-binding protein
E8M05_RS07155	COG0488	(ABC) transporter
E8M05_RS07175	COG1187	pseudouridine synthase activity
E8M05_RS07180	COG4166	transmembrane transport
E8M05_RS07195	COG2723	6-phospho-beta-galactosidase activity
E8M05_RS07200	COG1263	PTS System
E8M05_RS07200	COG2190	(PTS) system
E8M05_RS07200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E8M05_RS07225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E8M05_RS07230	COG1316	TRANSCRIPTIONal
E8M05_RS07235	COG0077	Prephenate dehydratase
E8M05_RS07240	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E8M05_RS07245	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E8M05_RS07250	COG0481	GTPase activity
E8M05_RS07280	COG1518	maintenance of DNA repeat elements
E8M05_RS07285	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
E8M05_RS07300	COG0647	UMP catabolic process
E8M05_RS07305	COG1051	belongs to the nudix hydrolase family
E8M05_RS07315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E8M05_RS07330	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E8M05_RS07335	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E8M05_RS07340	COG3442	glutamine amidotransferase
E8M05_RS07350	COG0148	phosphopyruvate hydratase activity
E8M05_RS07385	COG0107	imidazoleglycerol-phosphate synthase activity
E8M05_RS07395	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E8M05_RS07405	COG0560	Phosphoserine phosphatase
E8M05_RS07410	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E8M05_RS07420	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
E8M05_RS07440	COG0187	DNA topoisomerase II activity
E8M05_RS07450	COG0772	Belongs to the SEDS family
E8M05_RS07465	COG0038	chloride channel
E8M05_RS07470	COG0287	Prephenate dehydrogenase
E8M05_RS07470	COG1605	Chorismate mutase
E8M05_RS07485	COG0716	FMN binding
E8M05_RS07500	COG0017	Asparaginyl-tRNA synthetase
E8M05_RS07510	COG0436	Aminotransferase
E8M05_RS07535	COG2177	Part of the ABC transporter FtsEX involved in
E8M05_RS07540	COG2884	Cell division ATP-binding protein ftsE
E8M05_RS07550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E8M05_RS07575	COG1078	dGTPase activity
E8M05_RS07600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E8M05_RS07610	COG0772	Belongs to the SEDS family
E8M05_RS07620	COG1164	Oligoendopeptidase f
E8M05_RS07625	COG0386	Belongs to the glutathione peroxidase family
E8M05_RS07650	COG0588	phosphoglycerate mutase activity
E8M05_RS07665	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E8M05_RS07685	COG4443	Transcriptional Coactivator p15 (PC4)
E8M05_RS07695	COG0826	peptidase U32
E8M05_RS07740	COG2183	response to ionizing radiation
E8M05_RS07750	COG0701	Predicted permease
E8M05_RS07755	COG3689	TIGRFAM TIGR03943 family protein
E8M05_RS07760	COG3321	synthase
E8M05_RS07760	COG0604	alcohol dehydrogenase
E8M05_RS07765	COG0789	Transcriptional regulator
E8M05_RS07775	COG0552	protein localization to endoplasmic reticulum
E8M05_RS07780	COG0561	phosphatase activity
E8M05_RS07785	COG0561	phosphatase activity
E8M05_RS07795	COG0494	nUDIX hydrolase
E8M05_RS07800	COG1196	nuclear chromosome segregation
E8M05_RS07810	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E8M05_RS07815	COG5002	protein histidine kinase activity
E8M05_RS07820	COG0745	RESPONSE REGULATOR receiver
E8M05_RS07825	COG1126	abc transporter atp-binding protein
E8M05_RS07830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E8M05_RS07835	COG0765	amino acid transport
E8M05_RS07840	COG0765	amino acid transport
E8M05_RS07860	COG0745	RESPONSE REGULATOR receiver
E8M05_RS07880	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E8M05_RS07885	COG0438	transferase activity, transferring glycosyl groups
E8M05_RS07895	COG1609	Transcriptional regulator
E8M05_RS07900	COG0006	proline dipeptidase activity
E8M05_RS07915	COG3394	polysaccharide catabolic process
E8M05_RS07920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E8M05_RS07920	COG1263	PTS System
E8M05_RS07940	COG0163	prenyltransferase activity
E8M05_RS07945	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E8M05_RS07950	COG0583	DNA-binding transcription factor activity
E8M05_RS07955	COG1811	Na channel or pump
E8M05_RS07960	COG2723	6-phospho-beta-galactosidase activity
E8M05_RS07965	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E8M05_RS07970	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E8M05_RS07975	COG1447	Phosphotransferase system cellobiose-specific component IIA
E8M05_RS07995	COG3933	PFAM sigma-54 factor interaction domain-containing protein
E8M05_RS07995	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E8M05_RS08010	COG0778	Nitroreductase
E8M05_RS08030	COG2723	6-phospho-beta-galactosidase activity
E8M05_RS08035	COG1263	PTS System
E8M05_RS08035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E8M05_RS08035	COG2190	(PTS) system
E8M05_RS08045	COG2207	Transcriptional regulator
E8M05_RS08065	COG0557	exoribonuclease II activity
E8M05_RS08080	COG2814	Major facilitator Superfamily
E8M05_RS08085	COG0237	dephospho-CoA kinase activity
E8M05_RS08090	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E8M05_RS08100	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E8M05_RS08105	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E8M05_RS08115	COG1702	phosphate starvation-inducible protein PhoH
E8M05_RS08125	COG4479	Belongs to the UPF0346 family
E8M05_RS08135	COG2996	Protein conserved in bacteria
E8M05_RS08165	COG1674	ftsk spoiiie
E8M05_RS08170	COG0582	viral genome integration into host DNA
E8M05_RS08200	COG3764	Sortase (surface protein transpeptidase)
E8M05_RS08255	COG0456	acetyltransferase
E8M05_RS08290	COG0433	COG0433 Predicted ATPase
E8M05_RS08330	COG2161	toxin-antitoxin pair type II binding
E8M05_RS08365	COG1674	ftsk spoiiie
E8M05_RS08420	COG1396	sequence-specific DNA binding
E8M05_RS08440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E8M05_RS08450	COG2223	nitrite transmembrane transporter activity
E8M05_RS08460	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E8M05_RS08470	COG1940	carbohydrate kinase activity
E8M05_RS08475	COG1940	carbohydrate kinase activity
E8M05_RS08480	COG2723	6-phospho-beta-galactosidase activity
E8M05_RS08495	COG0366	Alpha amylase catalytic
E8M05_RS08500	COG1653	transport
E8M05_RS08505	COG0395	ABC-type sugar transport system, permease component
E8M05_RS08510	COG1175	transmembrane transport
E8M05_RS08515	COG0383	alpha-mannosidase activity
E8M05_RS08560	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E8M05_RS08575	COG1028	Short-chain dehydrogenase reductase Sdr
E8M05_RS08595	COG0534	Mate efflux family protein
E8M05_RS08610	COG0640	Transcriptional regulator
E8M05_RS08615	COG0708	Exodeoxyribonuclease III
E8M05_RS08635	COG1393	Belongs to the ArsC family
E8M05_RS08640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E8M05_RS08650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E8M05_RS08675	COG0004	ammonium transporteR
E8M05_RS08690	COG1774	PSP1 C-terminal conserved region
E8M05_RS08695	COG0470	DNA polymerase III
E8M05_RS08705	COG0517	IMP dehydrogenase activity
E8M05_RS08705	COG1227	inorganic diphosphatase activity
E8M05_RS08735	COG4471	UPF0298 protein
E8M05_RS08750	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E8M05_RS08755	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E8M05_RS08760	COG0626	cystathionine gamma-synthase activity
E8M05_RS08765	COG2244	polysaccharide biosynthetic process
E8M05_RS08770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E8M05_RS08775	COG1120	ATPase activity
E8M05_RS08780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E8M05_RS08785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E8M05_RS08790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E8M05_RS08810	COG1227	inorganic diphosphatase activity
E8M05_RS08820	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E8M05_RS08825	COG1253	flavin adenine dinucleotide binding
E8M05_RS08830	COG1119	ATPase activity
E8M05_RS08835	COG0025	NhaP-type Na H and K H
E8M05_RS08845	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
E8M05_RS08850	COG1242	4 iron, 4 sulfur cluster binding
E8M05_RS08855	COG0671	phosphoesterase, PA-phosphatase related
E8M05_RS08865	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
E8M05_RS08875	COG0531	amino acid
E8M05_RS08880	COG0569	domain protein
E8M05_RS08885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E8M05_RS08890	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E8M05_RS08895	COG1187	pseudouridine synthase activity
E8M05_RS08910	COG0582	viral genome integration into host DNA
E8M05_RS08930	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E8M05_RS08935	COG3763	UPF0154 protein
E8M05_RS08940	COG0582	viral genome integration into host DNA
E8M05_RS09040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E8M05_RS09060	COG1254	Belongs to the acylphosphatase family
E8M05_RS09075	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E8M05_RS09085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E8M05_RS09095	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E8M05_RS09105	COG1484	DNA-dependent DNA replication
E8M05_RS09120	COG5002	protein histidine kinase activity
E8M05_RS09125	COG0745	RESPONSE REGULATOR receiver
E8M05_RS09135	COG0501	Belongs to the peptidase M48B family
E8M05_RS09140	COG1704	LemA family
E8M05_RS09150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E8M05_RS09155	COG0569	domain protein
E8M05_RS09165	COG1122	ATPase activity
E8M05_RS09185	COG1114	Component of the transport system for branched-chain amino acids
E8M05_RS09190	COG2910	NAD(P)H-binding
E8M05_RS09195	COG1959	2 iron, 2 sulfur cluster binding
E8M05_RS09220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E8M05_RS09225	COG1473	amidohydrolase
E8M05_RS09235	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E8M05_RS09240	COG0217	transcriptional regulatory protein
E8M05_RS09245	COG0702	epimerase
E8M05_RS09250	COG0789	Transcriptional regulator
E8M05_RS09255	COG1323	Belongs to the UPF0348 family
E8M05_RS09260	COG2226	methyltransferase
E8M05_RS09265	COG0799	negative regulation of ribosome biogenesis
E8M05_RS09275	COG1713	HD superfamily hydrolase involved in NAD metabolism
E8M05_RS09280	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E8M05_RS09285	COG1534	Rna-binding protein
E8M05_RS09290	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E8M05_RS09295	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
E8M05_RS09300	COG2814	Major facilitator Superfamily
E8M05_RS09305	COG1846	Transcriptional regulator
E8M05_RS09320	COG0154	amidase activity
E8M05_RS09325	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E8M05_RS09330	COG1335	isochorismatase
E8M05_RS09335	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
E8M05_RS09340	COG0436	Aminotransferase
E8M05_RS09350	COG0589	response to stress
E8M05_RS09355	COG0561	phosphatase activity
E8M05_RS09360	COG0252	asparaginase activity
E8M05_RS09365	COG3655	Transcriptional regulator
E8M05_RS09380	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E8M05_RS09395	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E8M05_RS09400	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E8M05_RS09415	COG1940	carbohydrate kinase activity
E8M05_RS09420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E8M05_RS09420	COG1263	PTS System
E8M05_RS09420	COG2190	(PTS) system
E8M05_RS09425	COG1621	beta-fructofuranosidase activity
E8M05_RS09430	COG1609	Transcriptional regulator
E8M05_RS09435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E8M05_RS09445	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E8M05_RS09460	COG2131	deaminase
E8M05_RS09465	COG0006	proline dipeptidase activity
E8M05_RS09475	COG0598	Magnesium transport protein CorA
E8M05_RS09490	COG3655	Transcriptional regulator
E8M05_RS09500	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E8M05_RS09505	COG0629	single-stranded DNA binding
E8M05_RS09525	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E8M05_RS09535	COG3634	alkyl hydroperoxide reductase activity
E8M05_RS09540	COG0450	alkyl hydroperoxide reductase
E8M05_RS09555	COG1194	a g-specific adenine glycosylase
E8M05_RS09575	COG2223	nitrite transmembrane transporter activity
E8M05_RS09580	COG0431	NADPH-dependent FMN reductase
E8M05_RS09580	COG1053	succinate dehydrogenase
E8M05_RS09580	COG3976	FMN-binding domain protein
E8M05_RS09610	COG1940	carbohydrate kinase activity
E8M05_RS09660	COG0395	ABC-type sugar transport system, permease component
E8M05_RS09665	COG1175	transmembrane transport
E8M05_RS09685	COG1070	Carbohydrate kinase
E8M05_RS09705	COG3118	belongs to the thioredoxin family
E8M05_RS09715	COG0157	Belongs to the NadC ModD family
E8M05_RS09725	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E8M05_RS09745	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E8M05_RS09750	COG0681	Belongs to the peptidase S26 family
E8M05_RS09755	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E8M05_RS09770	COG1882	Formate acetyltransferase
E8M05_RS09775	COG2153	protein acetylation
E8M05_RS09785	COG2723	6-phospho-beta-galactosidase activity
E8M05_RS09800	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E8M05_RS09805	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E8M05_RS09815	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E8M05_RS09835	COG5002	protein histidine kinase activity
E8M05_RS09845	COG0704	Plays a role in the regulation of phosphate uptake
E8M05_RS09850	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E8M05_RS09855	COG0581	inorganic phosphate transmembrane transporter activity
E8M05_RS09860	COG0573	inorganic phosphate transmembrane transporter activity
E8M05_RS09935	COG0582	viral genome integration into host DNA
E8M05_RS09945	COG0789	Transcriptional regulator
E8M05_RS09960	COG2081	HI0933 family
E8M05_RS09990	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E8M05_RS10000	COG0456	acetyltransferase
E8M05_RS10005	COG1214	PFAM Peptidase M22, glycoprotease
E8M05_RS10010	COG5503	Protein of unknown function (DUF1447)
E8M05_RS10020	COG0493	'glutamate synthase
E8M05_RS10025	COG0067	glutamate synthase
E8M05_RS10025	COG0069	glutamate synthase activity
E8M05_RS10025	COG0070	glutamate synthase
E8M05_RS10030	COG0174	glutamine synthetase
E8M05_RS10035	COG0789	Transcriptional regulator
E8M05_RS10045	COG0126	phosphoglycerate kinase activity
E8M05_RS10055	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E8M05_RS10075	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E8M05_RS10225	COG0084	hydrolase, TatD family'
E8M05_RS10230	COG1132	(ABC) transporter
E8M05_RS10255	COG0281	malic enzyme
E8M05_RS10260	COG0583	DNA-binding transcription factor activity
E8M05_RS10265	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
E8M05_RS10270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E8M05_RS10275	COG1696	Membrane protein involved in D-alanine export
E8M05_RS10320	COG0594	ribonuclease P activity
E8M05_RS10335	COG2807	transmembrane transport
E8M05_RS10340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E8M05_RS10365	COG0756	dUTP diphosphatase activity
E8M05_RS10395	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E8M05_RS10405	COG2801	Transposase and inactivated derivatives
E8M05_RS10410	COG0457	Tetratricopeptide repeat
E8M05_RS10410	COG0705	Rhomboid family
E8M05_RS10415	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E8M05_RS10420	COG1473	amidohydrolase
E8M05_RS10425	COG2171	N-acyltransferase activity
E8M05_RS10430	COG0166	Belongs to the GPI family
E8M05_RS10450	COG1234	tRNA 3'-trailer cleavage
E8M05_RS10455	COG1268	BioY protein
E8M05_RS10465	COG0343	queuine tRNA-ribosyltransferase activity
E8M05_RS10480	COG3479	Phenolic acid decarboxylase
E8M05_RS10485	COG1695	Transcriptional regulator
E8M05_RS10490	COG1832	CoA-binding protein
E8M05_RS10495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E8M05_RS10495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E8M05_RS10505	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E8M05_RS10560	COG3623	hexulose-6-phosphate isomerase
E8M05_RS10570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E8M05_RS10580	COG3037	sugar-specific permease SgaT UlaA
E8M05_RS10585	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E8M05_RS10590	COG1181	Belongs to the D-alanine--D-alanine ligase family
E8M05_RS10590	COG2918	glutathione biosynthetic process
E8M05_RS10605	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E8M05_RS10610	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E8M05_RS10615	COG0542	response to heat
E8M05_RS10620	COG4463	regulation of RNA biosynthetic process
E8M05_RS10630	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E8M05_RS10645	COG1619	proteins homologs of microcin C7 resistance protein MccF
E8M05_RS10650	COG3590	peptidase
E8M05_RS10665	COG0366	Alpha amylase catalytic
E8M05_RS10670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E8M05_RS10670	COG1263	PTS System
E8M05_RS10675	COG2188	Transcriptional regulator
E8M05_RS10690	COG2255	four-way junction helicase activity
E8M05_RS10695	COG0602	queuosine metabolic process
E8M05_RS10705	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E8M05_RS10705	COG1328	CTP reductase activity
E8M05_RS10725	COG4472	Bacterial protein of unknown function (DUF965)
E8M05_RS10730	COG1393	Belongs to the ArsC family
E8M05_RS10740	COG1546	Belongs to the CinA family
E8M05_RS10740	COG1058	Belongs to the CinA family
E8M05_RS10805	COG1263	PTS System
E8M05_RS10805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E8M05_RS10805	COG2190	(PTS) system
E8M05_RS10810	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E8M05_RS10815	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E8M05_RS10845	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E8M05_RS10910	COG0791	NLP P60 protein
E8M05_RS10910	COG0741	lytic transglycosylase activity
E8M05_RS10940	COG2946	Replication initiation factor
E8M05_RS10955	COG1674	ftsk spoiiie
E8M05_RS10960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E8M05_RS11005	COG3759	membrane
E8M05_RS11010	COG1511	domain protein
E8M05_RS11015	COG1309	transcriptional regulator
E8M05_RS11025	COG4466	Protein conserved in bacteria
E8M05_RS11030	COG0305	Participates in initiation and elongation during chromosome replication
E8M05_RS11045	COG0445	tRNA wobble uridine modification
E8M05_RS11060	COG1760	l-serine dehydratase
E8M05_RS11065	COG1760	l-serine dehydratase
E8M05_RS11070	COG0546	phosphoglycolate phosphatase activity
E8M05_RS11075	COG0741	lytic transglycosylase activity
E8M05_RS11090	COG1122	ATPase activity
E8M05_RS11095	COG1122	ATPase activity
E8M05_RS11100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E8M05_RS11110	COG0612	Peptidase, M16
E8M05_RS11115	COG0612	Peptidase, M16
E8M05_RS11125	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E8M05_RS11135	COG0517	IMP dehydrogenase activity
E8M05_RS11135	COG0516	GMP reductase activity
E8M05_RS11145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E8M05_RS11150	COG0488	(ABC) transporter
E8M05_RS11185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E8M05_RS11190	COG1475	DNA binding