locus-tag	class	description
Sp14A_RS00010	COG0592	DNA-directed DNA polymerase activity
Sp14A_RS00025	COG0012	GTP binding
Sp14A_RS00030	COG0193	aminoacyl-tRNA hydrolase activity
Sp14A_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Sp14A_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Sp14A_RS00065	COG0037	tRNA processing
Sp14A_RS00070	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Sp14A_RS00075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Sp14A_RS00120	COG3022	response to hydroperoxide
Sp14A_RS00125	COG0457	Tetratricopeptide repeat
Sp14A_RS00125	COG0705	Rhomboid family
Sp14A_RS00130	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Sp14A_RS00135	COG4472	Bacterial protein of unknown function (DUF965)
Sp14A_RS00155	COG1328	CTP reductase activity
Sp14A_RS00175	COG0602	queuosine metabolic process
Sp14A_RS00295	COG3942	CHAP domain
Sp14A_RS00305	COG0436	Aminotransferase
Sp14A_RS00310	COG1381	Involved in DNA repair and RecF pathway recombination
Sp14A_RS00315	COG0416	fatty acid biosynthetic process
Sp14A_RS00320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Sp14A_RS00325	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Sp14A_RS00330	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Sp14A_RS00340	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Sp14A_RS00345	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Sp14A_RS00355	COG1388	LysM domain
Sp14A_RS00355	COG0860	N-Acetylmuramoyl-L-alanine amidase
Sp14A_RS00375	COG0151	Belongs to the GarS family
Sp14A_RS00380	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Sp14A_RS00405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Sp14A_RS00415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Sp14A_RS00425	COG2755	lipolytic protein G-D-S-L family
Sp14A_RS00425	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Sp14A_RS00430	COG2188	Transcriptional regulator
Sp14A_RS00435	COG1131	(ABC) transporter
Sp14A_RS00445	COG1012	belongs to the aldehyde dehydrogenase family
Sp14A_RS00445	COG1454	alcohol dehydrogenase
Sp14A_RS00455	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Sp14A_RS00465	COG0534	Mate efflux family protein
Sp14A_RS00470	COG0051	transcription antitermination factor activity, RNA binding
Sp14A_RS00480	COG0088	Forms part of the polypeptide exit tunnel
Sp14A_RS00490	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Sp14A_RS00510	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Sp14A_RS00515	COG0255	Belongs to the universal ribosomal protein uL29 family
Sp14A_RS00530	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Sp14A_RS00540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Sp14A_RS00575	COG0201	protein transport
Sp14A_RS00580	COG0563	adenylate kinase activity
Sp14A_RS00705	COG1121	(ABC) transporter
Sp14A_RS00710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Sp14A_RS00720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Sp14A_RS00740	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Sp14A_RS00745	COG1459	type II secretion system
Sp14A_RS00750	COG4537	Required for transformation and DNA binding
Sp14A_RS00780	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Sp14A_RS00795	COG1266	CAAX protease self-immunity
Sp14A_RS00800	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Sp14A_RS00805	COG1363	Peptidase, m42
Sp14A_RS00820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Sp14A_RS00825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Sp14A_RS00835	COG0561	phosphatase activity
Sp14A_RS00845	COG4585	Histidine kinase
Sp14A_RS00850	COG2197	response regulator
Sp14A_RS00870	COG3715	PTS system
Sp14A_RS00875	COG3716	PTS system mannose fructose sorbose family IID component
Sp14A_RS00885	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Sp14A_RS00890	COG0459	protein refolding
Sp14A_RS00900	COG1619	proteins homologs of microcin C7 resistance protein MccF
Sp14A_RS00905	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Sp14A_RS00905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Sp14A_RS00920	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Sp14A_RS00930	COG0542	response to heat
Sp14A_RS00935	COG0745	RESPONSE REGULATOR receiver
Sp14A_RS00940	COG5002	protein histidine kinase activity
Sp14A_RS00960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Sp14A_RS00990	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Sp14A_RS00995	COG1744	ABC transporter substrate-binding protein PnrA-like
Sp14A_RS01000	COG2188	Transcriptional regulator
Sp14A_RS01005	COG2222	sugar isomerase
Sp14A_RS01015	COG2186	Transcriptional regulator
Sp14A_RS01050	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Sp14A_RS01055	COG3715	PTS system
Sp14A_RS01060	COG3716	PTS system mannose fructose sorbose family IID component
Sp14A_RS01070	COG0564	pseudouridine synthase activity
Sp14A_RS01075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Sp14A_RS01095	COG0604	alcohol dehydrogenase
Sp14A_RS01100	COG0833	amino acid
Sp14A_RS01105	COG2040	homocysteine
Sp14A_RS01110	COG1737	Transcriptional regulator
Sp14A_RS01115	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
Sp14A_RS01120	COG2190	(PTS) system
Sp14A_RS01120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Sp14A_RS01120	COG1263	PTS System
Sp14A_RS01135	COG0495	leucyl-tRNA aminoacylation
Sp14A_RS01150	COG3655	Transcriptional regulator
Sp14A_RS01170	COG1122	ATPase activity
Sp14A_RS01180	COG2207	Transcriptional regulator
Sp14A_RS01185	COG3345	alpha-galactosidase
Sp14A_RS01190	COG1653	transport
Sp14A_RS01195	COG1175	transmembrane transport
Sp14A_RS01200	COG0395	ABC-type sugar transport system, permease component
Sp14A_RS01205	COG0366	Alpha amylase catalytic
Sp14A_RS01210	COG2272	Belongs to the type-B carboxylesterase lipase family
Sp14A_RS01215	COG2017	converts alpha-aldose to the beta-anomer
Sp14A_RS01225	COG3842	ATPase activity
Sp14A_RS01230	COG0366	Alpha amylase catalytic
Sp14A_RS01235	COG1609	Transcriptional regulator
Sp14A_RS01240	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Sp14A_RS01245	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
Sp14A_RS01250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Sp14A_RS01265	COG1862	Preprotein translocase
Sp14A_RS01275	COG4589	Belongs to the CDS family
Sp14A_RS01300	COG1234	tRNA 3'-trailer cleavage
Sp14A_RS01315	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Sp14A_RS01320	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Sp14A_RS01325	COG4509	Sortase family
Sp14A_RS01345	COG1193	negative regulation of DNA recombination
Sp14A_RS01350	COG4868	Belongs to the UPF0371 family
Sp14A_RS01355	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Sp14A_RS01360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Sp14A_RS01385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Sp14A_RS01400	COG0719	Fe-S assembly protein
Sp14A_RS01405	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Sp14A_RS01415	COG0719	Fe-S assembly protein
Sp14A_RS01420	COG1686	Belongs to the peptidase S11 family
Sp14A_RS01425	COG1686	Belongs to the peptidase S11 family
Sp14A_RS01430	COG4166	transmembrane transport
Sp14A_RS01435	COG0601	transmembrane transport
Sp14A_RS01440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Sp14A_RS01445	COG0444	Belongs to the ABC transporter superfamily
Sp14A_RS01450	COG4608	Belongs to the ABC transporter superfamily
Sp14A_RS01455	COG4166	transmembrane transport
Sp14A_RS01460	COG0601	transmembrane transport
Sp14A_RS01465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Sp14A_RS01470	COG0444	Belongs to the ABC transporter superfamily
Sp14A_RS01475	COG4608	Belongs to the ABC transporter superfamily
Sp14A_RS01605	COG0527	aspartate kinase activity
Sp14A_RS01610	COG1024	Enoyl-CoA hydratase
Sp14A_RS01615	COG1846	Transcriptional regulator
Sp14A_RS01630	COG2070	2-Nitropropane dioxygenase
Sp14A_RS01635	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Sp14A_RS01640	COG1028	Short-chain dehydrogenase reductase Sdr
Sp14A_RS01645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Sp14A_RS01660	COG0439	Biotin carboxylase
Sp14A_RS01690	COG3775	system Galactitol-specific IIC component
Sp14A_RS01720	COG3711	transcriptional antiterminator
Sp14A_RS01725	COG1447	Phosphotransferase system cellobiose-specific component IIA
Sp14A_RS01730	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Sp14A_RS01730	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Sp14A_RS01740	COG3037	sugar-specific permease SgaT UlaA
Sp14A_RS01760	COG3623	hexulose-6-phosphate isomerase
Sp14A_RS01790	COG3763	UPF0154 protein
Sp14A_RS01795	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Sp14A_RS01815	COG0582	viral genome integration into host DNA
Sp14A_RS01830	COG1187	pseudouridine synthase activity
Sp14A_RS01845	COG1283	sodium-dependent phosphate transmembrane transporter activity
Sp14A_RS01860	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Sp14A_RS01885	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Sp14A_RS01895	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Sp14A_RS01900	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Sp14A_RS01915	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Sp14A_RS01940	COG0768	penicillin binding
Sp14A_RS01950	COG0513	Belongs to the DEAD box helicase family
Sp14A_RS01955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sp14A_RS01965	COG1126	abc transporter atp-binding protein
Sp14A_RS01990	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Sp14A_RS02005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Sp14A_RS02025	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
Sp14A_RS02030	COG1114	Component of the transport system for branched-chain amino acids
Sp14A_RS02035	COG0569	domain protein
Sp14A_RS02040	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Sp14A_RS02050	COG0501	Belongs to the peptidase M48B family
Sp14A_RS02055	COG1399	metal-binding, possibly nucleic acid-binding protein
Sp14A_RS02060	COG0745	RESPONSE REGULATOR receiver
Sp14A_RS02065	COG5002	protein histidine kinase activity
Sp14A_RS02080	COG1484	DNA-dependent DNA replication
Sp14A_RS02090	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Sp14A_RS02110	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Sp14A_RS02125	COG1254	Belongs to the acylphosphatase family
Sp14A_RS02135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Sp14A_RS02160	COG2137	regulation of response to DNA damage stimulus
Sp14A_RS02165	COG3231	kanamycin kinase activity
Sp14A_RS02190	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Sp14A_RS02205	COG3716	PTS system mannose fructose sorbose family IID component
Sp14A_RS02210	COG3715	PTS system
Sp14A_RS02220	COG0561	phosphatase activity
Sp14A_RS02230	COG2252	PERMEase
Sp14A_RS02235	COG0802	atpase or kinase
Sp14A_RS02250	COG1316	TRANSCRIPTIONal
Sp14A_RS02255	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
Sp14A_RS02260	COG0671	phosphoesterase, PA-phosphatase related
Sp14A_RS02270	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Sp14A_RS02280	COG0025	NhaP-type Na H and K H
Sp14A_RS02285	COG0525	valine-tRNA ligase activity
Sp14A_RS02320	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Sp14A_RS02325	COG1393	Belongs to the ArsC family
Sp14A_RS02330	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Sp14A_RS02335	COG1253	flavin adenine dinucleotide binding
Sp14A_RS02340	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Sp14A_RS02345	COG1227	inorganic diphosphatase activity
Sp14A_RS02350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Sp14A_RS02355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Sp14A_RS02360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Sp14A_RS02365	COG1120	ATPase activity
Sp14A_RS02375	COG2244	polysaccharide biosynthetic process
Sp14A_RS02385	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Sp14A_RS02390	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Sp14A_RS02430	COG0517	IMP dehydrogenase activity
Sp14A_RS02435	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Sp14A_RS02440	COG0470	DNA polymerase III
Sp14A_RS02465	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Sp14A_RS02475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Sp14A_RS02500	COG0742	ribosomal rna small subunit methyltransferase
Sp14A_RS02505	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Sp14A_RS02510	COG3480	Lon protease (S16) C-terminal proteolytic domain
Sp14A_RS02515	COG1609	Transcriptional regulator
Sp14A_RS02520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Sp14A_RS02525	COG1869	D-ribose catabolic process
Sp14A_RS02535	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sp14A_RS02540	COG1879	ABC-type sugar transport system periplasmic component
Sp14A_RS02550	COG0346	lactoylglutathione lyase activity
Sp14A_RS02560	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Sp14A_RS02565	COG0081	regulation of translation
Sp14A_RS02570	COG1132	(ABC) transporter
Sp14A_RS02580	COG0233	cytoplasmic translational termination
Sp14A_RS02590	COG4974	Belongs to the 'phage' integrase family
Sp14A_RS02610	COG1396	sequence-specific DNA binding
Sp14A_RS02765	COG1396	sequence-specific DNA binding
Sp14A_RS02915	COG1783	phage Terminase large subunit
Sp14A_RS03050	COG1702	phosphate starvation-inducible protein PhoH
Sp14A_RS03055	COG0668	transmembrane transport
Sp14A_RS03065	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Sp14A_RS03070	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Sp14A_RS03095	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Sp14A_RS03110	COG0433	COG0433 Predicted ATPase
Sp14A_RS03125	COG2814	Major facilitator Superfamily
Sp14A_RS03140	COG0557	exoribonuclease II activity
Sp14A_RS03155	COG1609	Transcriptional regulator
Sp14A_RS03165	COG1175	transmembrane transport
Sp14A_RS03170	COG0395	ABC-type sugar transport system, permease component
Sp14A_RS03175	COG1621	beta-fructofuranosidase activity
Sp14A_RS03180	COG1012	belongs to the aldehyde dehydrogenase family
Sp14A_RS03185	COG0346	lactoylglutathione lyase activity
Sp14A_RS03190	COG0778	Nitroreductase
Sp14A_RS03195	COG0038	chloride channel
Sp14A_RS03215	COG1609	Transcriptional regulator
Sp14A_RS03230	COG0438	transferase activity, transferring glycosyl groups
Sp14A_RS03235	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Sp14A_RS03240	COG2376	Dihydroxyacetone kinase
Sp14A_RS03245	COG1461	Dihydroxyacetone kinase
Sp14A_RS03250	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
Sp14A_RS03280	COG0363	glucosamine-6-phosphate deaminase activity
Sp14A_RS03285	COG0435	Glutathione S-transferase
Sp14A_RS03290	COG1187	pseudouridine synthase activity
Sp14A_RS03315	COG0546	phosphoglycolate phosphatase activity
Sp14A_RS03320	COG2223	nitrite transmembrane transporter activity
Sp14A_RS03325	COG4122	O-methyltransferase activity
Sp14A_RS03330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Sp14A_RS03345	COG0531	amino acid
Sp14A_RS03360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Sp14A_RS03370	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Sp14A_RS03385	COG1012	belongs to the aldehyde dehydrogenase family
Sp14A_RS03390	COG0726	polysaccharide deacetylase
Sp14A_RS03420	COG1956	GAF domain-containing protein
Sp14A_RS03425	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Sp14A_RS03435	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Sp14A_RS03435	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Sp14A_RS03450	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Sp14A_RS03460	COG4109	DRTGG domain
Sp14A_RS03465	COG0024	Methionine aminopeptidase
Sp14A_RS03470	COG1295	ribonuclease BN
Sp14A_RS03475	COG2246	polysaccharide biosynthetic process
Sp14A_RS03480	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Sp14A_RS03490	COG0625	glutathione transferase activity
Sp14A_RS03495	COG0716	FMN binding
Sp14A_RS03500	COG0038	chloride channel
Sp14A_RS03505	COG0335	large ribosomal subunit rRNA binding
Sp14A_RS03520	COG0772	Belongs to the SEDS family
Sp14A_RS03530	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
Sp14A_RS03550	COG0148	phosphopyruvate hydratase activity
Sp14A_RS03655	COG0860	N-Acetylmuramoyl-L-alanine amidase
Sp14A_RS03660	COG2195	Cleaves the N-terminal amino acid of tripeptides
Sp14A_RS03685	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Sp14A_RS03690	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Sp14A_RS03695	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Sp14A_RS03715	COG1970	mechanosensitive ion channel activity
Sp14A_RS03720	COG0358	DNA primase activity
Sp14A_RS03725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Sp14A_RS03730	COG2151	metal-sulfur cluster biosynthetic enzyme
Sp14A_RS03735	COG0463	Glycosyl transferase, family 2
Sp14A_RS03740	COG1091	dTDP-4-dehydrorhamnose reductase activity
Sp14A_RS03765	COG1442	glycosyl transferase family 8
Sp14A_RS03765	COG1216	Glycosyl transferase, family 2
Sp14A_RS03790	COG0463	Glycosyl transferase, family 2
Sp14A_RS03800	COG1136	(ABC) transporter
Sp14A_RS03805	COG0577	efflux transmembrane transporter activity
Sp14A_RS03825	COG0228	four-way junction DNA binding
Sp14A_RS03830	COG1837	Belongs to the UPF0109 family
Sp14A_RS03855	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Sp14A_RS03860	COG0336	Belongs to the RNA methyltransferase TrmD family
Sp14A_RS03865	COG0492	ferredoxin-NADP+ reductase activity
Sp14A_RS03870	COG1349	DNA-binding transcription factor activity
Sp14A_RS03875	COG1105	Belongs to the carbohydrate kinase PfkB family
Sp14A_RS03880	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Sp14A_RS03880	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Sp14A_RS03880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Sp14A_RS03885	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Sp14A_RS03885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Sp14A_RS03885	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Sp14A_RS03890	COG3942	CHAP domain
Sp14A_RS03890	COG1705	Flagellar rod assembly protein muramidase FlgJ
Sp14A_RS03910	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Sp14A_RS03920	COG0488	(ABC) transporter
Sp14A_RS03930	COG0534	Mate efflux family protein
Sp14A_RS03935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Sp14A_RS03945	COG1132	(ABC) transporter
Sp14A_RS03955	COG3711	transcriptional antiterminator
Sp14A_RS03960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Sp14A_RS03960	COG2190	(PTS) system
Sp14A_RS03960	COG1263	PTS System
Sp14A_RS03990	COG1917	Cupin 2, conserved barrel domain protein
Sp14A_RS03990	COG4977	sequence-specific DNA binding
Sp14A_RS04005	COG0673	inositol 2-dehydrogenase activity
Sp14A_RS04015	COG1940	carbohydrate kinase activity
Sp14A_RS04025	COG1744	ABC transporter substrate-binding protein PnrA-like
Sp14A_RS04045	COG0561	phosphatase activity
Sp14A_RS04050	COG2723	6-phospho-beta-galactosidase activity
Sp14A_RS04060	COG0588	phosphoglycerate mutase activity
Sp14A_RS04065	COG2723	6-phospho-beta-galactosidase activity
Sp14A_RS04075	COG0561	phosphatase activity
Sp14A_RS04085	COG0346	lactoylglutathione lyase activity
Sp14A_RS04095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Sp14A_RS04105	COG0242	peptide deformylase activity
Sp14A_RS04110	COG0431	NADPH-dependent FMN reductase
Sp14A_RS04115	COG3448	diguanylate cyclase activity
Sp14A_RS04115	COG4175	Glycine betaine
Sp14A_RS04125	COG2357	RelA SpoT domain protein
Sp14A_RS04130	COG0745	RESPONSE REGULATOR receiver
Sp14A_RS04140	COG0583	DNA-binding transcription factor activity
Sp14A_RS04145	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Sp14A_RS04170	COG1304	FMN binding
Sp14A_RS04180	COG3425	synthase
Sp14A_RS04190	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Sp14A_RS04200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Sp14A_RS04275	COG0270	DNA (cytosine-5-)-methyltransferase activity
Sp14A_RS04435	COG3843	relaxase mobilization nuclease domain protein
Sp14A_RS04465	COG1396	sequence-specific DNA binding
Sp14A_RS04470	COG0542	response to heat
Sp14A_RS04580	COG1705	Flagellar rod assembly protein muramidase FlgJ
Sp14A_RS04580	COG3942	CHAP domain
Sp14A_RS04805	COG1396	sequence-specific DNA binding
Sp14A_RS04815	COG4974	Belongs to the 'phage' integrase family
Sp14A_RS04830	COG1132	(ABC) transporter
Sp14A_RS04835	COG2755	lipolytic protein G-D-S-L family
Sp14A_RS04835	COG0657	acetylesterase activity
Sp14A_RS04845	COG1573	uracil-dna glycosylase
Sp14A_RS04850	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Sp14A_RS04875	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Sp14A_RS04900	COG4120	Belongs to the binding-protein-dependent transport system permease family
Sp14A_RS04925	COG2962	Rard protein
Sp14A_RS04935	COG2962	Rard protein
Sp14A_RS04940	COG0285	dihydrofolate synthase activity
Sp14A_RS04975	COG1176	ABC-type spermidine putrescine transport system, permease component I
Sp14A_RS04980	COG1177	transmembrane transport
Sp14A_RS05025	COG0560	Phosphoserine phosphatase
Sp14A_RS05035	COG1187	pseudouridine synthase activity
Sp14A_RS05040	COG2309	aminopeptidase activity
Sp14A_RS05065	COG0584	glycerophosphoryl diester phosphodiesterase
Sp14A_RS05070	COG0488	(ABC) transporter
Sp14A_RS05075	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Sp14A_RS05080	COG1126	abc transporter atp-binding protein
Sp14A_RS05085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sp14A_RS05105	COG0556	nucleotide-excision repair
Sp14A_RS05115	COG3833	ABC-type maltose transport systems, permease component
Sp14A_RS05120	COG1175	transmembrane transport
Sp14A_RS05130	COG1609	Transcriptional regulator
Sp14A_RS05135	COG1640	4-alpha-glucanotransferase
Sp14A_RS05140	COG0058	SHG alpha-glucan phosphorylase activity
Sp14A_RS05145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sp14A_RS05150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sp14A_RS05195	COG0583	DNA-binding transcription factor activity
Sp14A_RS05200	COG0284	orotidine-5'-phosphate decarboxylase activity
Sp14A_RS05205	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Sp14A_RS05215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sp14A_RS05220	COG0765	amino acid transport
Sp14A_RS05225	COG1881	PFAM PEBP family protein
Sp14A_RS05230	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Sp14A_RS05255	COG0187	DNA topoisomerase II activity
Sp14A_RS05270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Sp14A_RS05290	COG0539	negative regulation of cytoplasmic translation
Sp14A_RS05305	COG0398	Pfam SNARE associated Golgi protein
Sp14A_RS05320	COG0205	6-phosphofructokinase activity
Sp14A_RS05325	COG0469	pyruvate kinase activity
Sp14A_RS05340	COG2213	PTS system mannitol-specific
Sp14A_RS05345	COG3711	transcriptional antiterminator
Sp14A_RS05350	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Sp14A_RS05355	COG0246	Mannitol dehydrogenase
Sp14A_RS05360	COG2824	Alkylphosphonate utilization operon protein PhnA
Sp14A_RS05365	COG0765	amino acid transport
Sp14A_RS05370	COG1126	abc transporter atp-binding protein
Sp14A_RS05375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sp14A_RS05395	COG0488	(ABC) transporter
Sp14A_RS05405	COG1876	peptidase activity
Sp14A_RS05445	COG1937	Protein conserved in bacteria
Sp14A_RS05450	COG1054	Belongs to the UPF0176 family
Sp14A_RS05460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Sp14A_RS05460	COG0425	Belongs to the sulfur carrier protein TusA family
Sp14A_RS05465	COG1764	response to oxidative stress
Sp14A_RS05470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Sp14A_RS05475	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Sp14A_RS05525	COG0110	maltose O-acetyltransferase activity
Sp14A_RS05530	COG0758	DNA mediated transformation
Sp14A_RS05535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Sp14A_RS05580	COG1136	(ABC) transporter
Sp14A_RS05585	COG0577	efflux transmembrane transporter activity
Sp14A_RS05590	COG0745	RESPONSE REGULATOR receiver
Sp14A_RS05595	COG5002	protein histidine kinase activity
Sp14A_RS05610	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Sp14A_RS05615	COG4974	Belongs to the 'phage' integrase family
Sp14A_RS05670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Sp14A_RS05680	COG1136	(ABC) transporter
Sp14A_RS05705	COG3764	Sortase (surface protein transpeptidase)
Sp14A_RS05725	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Sp14A_RS05730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Sp14A_RS05735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Sp14A_RS05750	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Sp14A_RS05760	COG0095	Lipoate-protein ligase
Sp14A_RS05765	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Sp14A_RS05770	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Sp14A_RS05775	COG4684	Psort location CytoplasmicMembrane, score
Sp14A_RS05780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Sp14A_RS05785	COG1132	(ABC) transporter
Sp14A_RS05805	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Sp14A_RS05815	COG0009	L-threonylcarbamoyladenylate synthase
Sp14A_RS05820	COG2890	protein-(glutamine-N5) methyltransferase activity
Sp14A_RS05830	COG1435	thymidine kinase activity
Sp14A_RS05855	COG1079	Belongs to the binding-protein-dependent transport system permease family
Sp14A_RS05860	COG4603	Belongs to the binding-protein-dependent transport system permease family
Sp14A_RS05865	COG3845	ABC transporter
Sp14A_RS05870	COG1744	ABC transporter substrate-binding protein PnrA-like
Sp14A_RS05875	COG0295	cytidine deaminase activity
Sp14A_RS05880	COG2813	Specifically methylates the guanine in position
Sp14A_RS05895	COG5002	protein histidine kinase activity
Sp14A_RS05900	COG0745	RESPONSE REGULATOR receiver
Sp14A_RS05910	COG0704	Plays a role in the regulation of phosphate uptake
Sp14A_RS05915	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Sp14A_RS05920	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Sp14A_RS05925	COG0581	inorganic phosphate transmembrane transporter activity
Sp14A_RS05930	COG0573	inorganic phosphate transmembrane transporter activity
Sp14A_RS05940	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Sp14A_RS05940	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Sp14A_RS05945	COG0483	inositol monophosphate 1-phosphatase activity
Sp14A_RS05960	COG0196	riboflavin kinase activity
Sp14A_RS05965	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Sp14A_RS06030	COG2261	transglycosylase associated protein
Sp14A_RS06040	COG1115	amino acid carrier protein
Sp14A_RS06045	COG1115	amino acid carrier protein
Sp14A_RS06050	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Sp14A_RS06055	COG4221	oxidoreductase activity
Sp14A_RS06060	COG0280	phosphate acetyltransferase
Sp14A_RS06065	COG0564	pseudouridine synthase activity
Sp14A_RS06075	COG2357	RelA SpoT domain protein
Sp14A_RS06095	COG1104	cysteine desulfurase activity
Sp14A_RS06115	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Sp14A_RS06125	COG0628	permease
Sp14A_RS06135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Sp14A_RS06190	COG1316	TRANSCRIPTIONal
Sp14A_RS06205	COG0322	excinuclease ABC activity
Sp14A_RS06210	COG1011	Hydrolase
Sp14A_RS06215	COG0656	L-ascorbic acid biosynthetic process
Sp14A_RS06225	COG4989	oxidoreductase activity
Sp14A_RS06240	COG3583	domain protein
Sp14A_RS06245	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Sp14A_RS06260	COG0142	geranyltranstransferase activity
Sp14A_RS06265	COG1252	NADH dehydrogenase
Sp14A_RS06285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Sp14A_RS06295	COG2188	Transcriptional regulator
Sp14A_RS06315	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Sp14A_RS06320	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Sp14A_RS06325	COG3442	glutamine amidotransferase
Sp14A_RS06340	COG0488	(ABC) transporter
Sp14A_RS06360	COG3842	ATPase activity
Sp14A_RS06375	COG0133	tryptophan synthase activity
Sp14A_RS06380	COG1293	RNA-binding protein homologous to eukaryotic snRNP
Sp14A_RS06385	COG0457	Tetratricopeptide repeat
Sp14A_RS06390	COG0628	permease
Sp14A_RS06395	COG1051	belongs to the nudix hydrolase family
Sp14A_RS06400	COG2706	6-phosphogluconolactonase activity
Sp14A_RS06410	COG1088	dTDP-glucose 4,6-dehydratase activity
Sp14A_RS06425	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Sp14A_RS06430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Sp14A_RS06445	COG2384	SAM-dependent methyltransferase
Sp14A_RS06475	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Sp14A_RS06475	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Sp14A_RS06480	COG0667	Aldo Keto reductase
Sp14A_RS06485	COG0300	oxidoreductase activity
Sp14A_RS06500	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Sp14A_RS06530	COG0028	Belongs to the TPP enzyme family
Sp14A_RS06540	COG0647	UMP catabolic process
Sp14A_RS06575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Sp14A_RS06600	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Sp14A_RS06610	COG0515	serine threonine protein kinase
Sp14A_RS06610	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Sp14A_RS06620	COG1396	sequence-specific DNA binding
Sp14A_RS06625	COG3843	relaxase mobilization nuclease domain protein
Sp14A_RS06655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Sp14A_RS06805	COG0270	DNA (cytosine-5-)-methyltransferase activity
Sp14A_RS06830	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Sp14A_RS06840	COG0438	transferase activity, transferring glycosyl groups
Sp14A_RS06850	COG1104	cysteine desulfurase activity
Sp14A_RS06875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Sp14A_RS06885	COG0505	Belongs to the CarA family
Sp14A_RS06890	COG0540	Belongs to the ATCase OTCase family
Sp14A_RS06895	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Sp14A_RS06900	COG0564	pseudouridine synthase activity
Sp14A_RS06910	COG0583	DNA-binding transcription factor activity
Sp14A_RS06930	COG1028	Short-chain dehydrogenase reductase Sdr
Sp14A_RS06945	COG4129	membrane
Sp14A_RS06965	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Sp14A_RS07070	COG0270	DNA (cytosine-5-)-methyltransferase activity
Sp14A_RS07090	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Sp14A_RS07110	COG0710	3-dehydroquinate dehydratase activity
Sp14A_RS07115	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Sp14A_RS07120	COG1368	sulfuric ester hydrolase activity
Sp14A_RS07165	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Sp14A_RS07205	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Sp14A_RS07210	COG0356	it plays a direct role in the translocation of protons across the membrane
Sp14A_RS07220	COG0297	glycogen (starch) synthase activity
Sp14A_RS07225	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Sp14A_RS07230	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Sp14A_RS07235	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Sp14A_RS07240	COG1523	belongs to the glycosyl hydrolase 13 family
Sp14A_RS07245	COG1597	lipid kinase activity
Sp14A_RS07250	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Sp14A_RS07255	COG4708	membrane
Sp14A_RS07280	COG1660	Displays ATPase and GTPase activities
Sp14A_RS07285	COG1074	ATP-dependent DNA helicase activity
Sp14A_RS07295	COG2321	neutral zinc metallopeptidase
Sp14A_RS07305	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Sp14A_RS07350	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Sp14A_RS07355	COG0511	ligase activity, forming carbon-carbon bonds
Sp14A_RS07365	COG2851	Citrate transporter
Sp14A_RS07385	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
Sp14A_RS07400	COG0436	Aminotransferase
Sp14A_RS07405	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Sp14A_RS07405	COG1199	ATP-dependent helicase activity
Sp14A_RS07410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Sp14A_RS07420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Sp14A_RS07430	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Sp14A_RS07445	COG2177	Part of the ABC transporter FtsEX involved in
Sp14A_RS07450	COG2884	Cell division ATP-binding protein ftsE
Sp14A_RS07460	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Sp14A_RS07480	COG1078	dGTPase activity
Sp14A_RS07500	COG0149	triose-phosphate isomerase activity
Sp14A_RS07510	COG0772	Belongs to the SEDS family
Sp14A_RS07520	COG1164	Oligoendopeptidase f
Sp14A_RS07540	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Sp14A_RS07550	COG3859	Proton-coupled thiamine transporter YuaJ
Sp14A_RS07565	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Sp14A_RS07570	COG3304	Inner membrane component domain
Sp14A_RS07575	COG0588	phosphoglycerate mutase activity
Sp14A_RS07590	COG4443	Transcriptional Coactivator p15 (PC4)
Sp14A_RS07625	COG3091	SprT-like family
Sp14A_RS07630	COG2183	response to ionizing radiation
Sp14A_RS07635	COG1114	Component of the transport system for branched-chain amino acids
Sp14A_RS07640	COG0704	Plays a role in the regulation of phosphate uptake
Sp14A_RS07645	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Sp14A_RS07650	COG0581	inorganic phosphate transmembrane transporter activity
Sp14A_RS07655	COG0573	inorganic phosphate transmembrane transporter activity
Sp14A_RS07660	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Sp14A_RS07670	COG5002	protein histidine kinase activity
Sp14A_RS07675	COG0745	RESPONSE REGULATOR receiver
Sp14A_RS07765	COG0463	Glycosyl transferase, family 2
Sp14A_RS07790	COG2274	protein secretion by the type I secretion system
Sp14A_RS07795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Sp14A_RS07830	COG0346	lactoylglutathione lyase activity
Sp14A_RS07850	COG0701	Predicted permease
Sp14A_RS07855	COG3689	TIGRFAM TIGR03943 family protein
Sp14A_RS07860	COG0531	amino acid
Sp14A_RS07865	COG0552	protein localization to endoplasmic reticulum
Sp14A_RS07870	COG0561	phosphatase activity
Sp14A_RS07875	COG0561	phosphatase activity
Sp14A_RS07880	COG1196	nuclear chromosome segregation
Sp14A_RS07890	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Sp14A_RS07895	COG5002	protein histidine kinase activity
Sp14A_RS07900	COG0745	RESPONSE REGULATOR receiver
Sp14A_RS07905	COG1126	abc transporter atp-binding protein
Sp14A_RS07910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sp14A_RS07915	COG0765	amino acid transport
Sp14A_RS07920	COG0765	amino acid transport
Sp14A_RS07925	COG2197	response regulator
Sp14A_RS07930	COG4585	Histidine kinase
Sp14A_RS07935	COG0842	Transport permease protein
Sp14A_RS07935	COG1511	domain protein
Sp14A_RS07940	COG1131	(ABC) transporter
Sp14A_RS07950	COG2333	competence protein COMEC
Sp14A_RS07950	COG0658	competence protein
Sp14A_RS07970	COG1131	(ABC) transporter
Sp14A_RS07980	COG0658	competence protein
Sp14A_RS07980	COG2333	competence protein COMEC
Sp14A_RS07985	COG1555	photosystem II stabilization
Sp14A_RS07985	COG1596	polysaccharide export
Sp14A_RS07990	COG0204	Acyl-transferase
Sp14A_RS08000	COG1755	Isoprenylcysteine carboxyl methyltransferase
Sp14A_RS08010	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Sp14A_RS08020	COG0513	Belongs to the DEAD box helicase family
Sp14A_RS08050	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Sp14A_RS08060	COG1181	Belongs to the D-alanine--D-alanine ligase family
Sp14A_RS08070	COG0768	penicillin binding
Sp14A_RS08080	COG0167	dihydroorotate dehydrogenase activity
Sp14A_RS08110	COG2755	lipolytic protein G-D-S-L family
Sp14A_RS08115	COG1307	EDD domain protein, DegV family
Sp14A_RS08120	COG0497	DNA recombination
Sp14A_RS08130	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Sp14A_RS08150	COG0667	Aldo Keto reductase
Sp14A_RS08155	COG1272	protein, Hemolysin III
Sp14A_RS08165	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Sp14A_RS08170	COG1126	abc transporter atp-binding protein
Sp14A_RS08175	COG0765	amino acid transport
Sp14A_RS08180	COG4703	Protein of unknown function (DUF1797)
Sp14A_RS08185	COG0542	response to heat
Sp14A_RS08200	COG0494	nUDIX hydrolase
Sp14A_RS08215	COG3599	regulation of cell shape
Sp14A_RS08235	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Sp14A_RS08250	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Sp14A_RS08270	COG1217	gtp-binding protein TYPA
Sp14A_RS08280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Sp14A_RS08285	COG1940	carbohydrate kinase activity
Sp14A_RS08295	COG0783	Belongs to the Dps family
Sp14A_RS08300	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Sp14A_RS08305	COG1132	(ABC) transporter
Sp14A_RS08310	COG1132	(ABC) transporter
Sp14A_RS08330	COG4470	Protein conserved in bacteria
Sp14A_RS08345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Sp14A_RS08350	COG1321	iron dependent repressor
Sp14A_RS08350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Sp14A_RS08355	COG1121	(ABC) transporter
Sp14A_RS08360	COG0803	Belongs to the bacterial solute-binding protein 9 family
Sp14A_RS08370	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Sp14A_RS08380	COG0494	nUDIX hydrolase
Sp14A_RS08395	COG0673	inositol 2-dehydrogenase activity
Sp14A_RS08405	COG1028	Short-chain dehydrogenase reductase Sdr
Sp14A_RS08430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Sp14A_RS08430	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Sp14A_RS08530	COG0582	viral genome integration into host DNA
Sp14A_RS08555	COG1304	FMN binding
Sp14A_RS08560	COG0708	Exodeoxyribonuclease III
Sp14A_RS08575	COG1418	mRNA catabolic process
Sp14A_RS08655	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
Sp14A_RS08660	COG1739	Uncharacterized protein family UPF0029
Sp14A_RS08680	COG1098	S1 RNA binding domain
Sp14A_RS08690	COG2197	response regulator
Sp14A_RS08695	COG4585	Histidine kinase
Sp14A_RS08705	COG0515	serine threonine protein kinase
Sp14A_RS08705	COG2815	serine threonine protein kinase
Sp14A_RS08715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Sp14A_RS08715	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Sp14A_RS08725	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Sp14A_RS08730	COG1758	RNA polymerase activity
Sp14A_RS08760	COG0116	Belongs to the methyltransferase superfamily
Sp14A_RS08770	COG3599	regulation of cell shape
Sp14A_RS08780	COG3331	DNA recombination
Sp14A_RS08785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Sp14A_RS08790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sp14A_RS08800	COG1323	Belongs to the UPF0348 family
Sp14A_RS08805	COG2226	methyltransferase
Sp14A_RS08810	COG0799	negative regulation of ribosome biogenesis
Sp14A_RS08820	COG1713	HD superfamily hydrolase involved in NAD metabolism
Sp14A_RS08825	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Sp14A_RS08830	COG1534	Rna-binding protein
Sp14A_RS08835	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Sp14A_RS08855	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Sp14A_RS08870	COG1335	isochorismatase
Sp14A_RS08875	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
Sp14A_RS08880	COG0436	Aminotransferase
Sp14A_RS08885	COG0589	response to stress
Sp14A_RS08890	COG0561	phosphatase activity
Sp14A_RS08895	COG0252	asparaginase activity
Sp14A_RS08905	COG4989	oxidoreductase activity
Sp14A_RS08910	COG0737	Belongs to the 5'-nucleotidase family
Sp14A_RS08920	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Sp14A_RS08935	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Sp14A_RS08940	COG0195	Participates in both transcription termination and antitermination
Sp14A_RS08970	COG4473	ABC transporter
Sp14A_RS08975	COG1131	(ABC) transporter
Sp14A_RS08980	COG0537	adenosine 5'-monophosphoramidase activity
Sp14A_RS09000	COG0569	domain protein
Sp14A_RS09005	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Sp14A_RS09020	COG0561	phosphatase activity
Sp14A_RS09025	COG0561	phosphatase activity
Sp14A_RS09030	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Sp14A_RS09040	COG0736	holo-[acyl-carrier-protein] synthase activity
Sp14A_RS09045	COG0653	protein targeting
Sp14A_RS09055	COG1482	cell wall glycoprotein biosynthetic process
Sp14A_RS09060	COG1940	carbohydrate kinase activity
Sp14A_RS09065	COG2190	(PTS) system
Sp14A_RS09065	COG1263	PTS System
Sp14A_RS09065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Sp14A_RS09070	COG1621	beta-fructofuranosidase activity
Sp14A_RS09075	COG1609	Transcriptional regulator
Sp14A_RS09080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Sp14A_RS09095	COG2131	deaminase
Sp14A_RS09100	COG0006	proline dipeptidase activity
Sp14A_RS09130	COG2851	Citrate transporter
Sp14A_RS09135	COG0473	3-isopropylmalate dehydrogenase activity
Sp14A_RS09150	COG0360	Binds together with S18 to 16S ribosomal RNA
Sp14A_RS09165	COG1194	a g-specific adenine glycosylase
Sp14A_RS09170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Sp14A_RS09190	COG0789	Transcriptional regulator
Sp14A_RS09195	COG0110	maltose O-acetyltransferase activity
Sp14A_RS09200	COG0702	epimerase
Sp14A_RS09210	COG1174	glycine betaine transport
Sp14A_RS09225	COG1063	alcohol dehydrogenase
Sp14A_RS09230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Sp14A_RS09235	COG3118	belongs to the thioredoxin family
Sp14A_RS09240	COG1902	pentaerythritol trinitrate reductase activity
Sp14A_RS09265	COG0765	amino acid transport
Sp14A_RS09300	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Sp14A_RS09325	COG0504	CTP synthase activity
Sp14A_RS09335	COG0371	Dehydrogenase
Sp14A_RS09350	COG0004	ammonium transporteR
Sp14A_RS09380	COG1902	pentaerythritol trinitrate reductase activity
Sp14A_RS09390	COG3192	ethanolamine utilization protein
Sp14A_RS09395	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
Sp14A_RS09405	COG4869	propanediol catabolic process
Sp14A_RS09425	COG1454	alcohol dehydrogenase
Sp14A_RS09425	COG1012	belongs to the aldehyde dehydrogenase family
Sp14A_RS09430	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Sp14A_RS09440	COG4302	ethanolamine ammonia-lyase activity
Sp14A_RS09465	COG2096	Adenosyltransferase
Sp14A_RS09580	COG0582	viral genome integration into host DNA
Sp14A_RS09585	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Sp14A_RS09590	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Sp14A_RS09605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Sp14A_RS09620	COG0756	dUTP diphosphatase activity
Sp14A_RS09630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Sp14A_RS09630	COG1263	PTS System
Sp14A_RS09635	COG0366	Alpha amylase catalytic
Sp14A_RS09645	COG1737	Transcriptional regulator
Sp14A_RS09650	COG2832	Protein of unknown function (DUF454)
Sp14A_RS09660	COG3976	FMN-binding domain protein
Sp14A_RS09660	COG0431	NADPH-dependent FMN reductase
Sp14A_RS09660	COG1053	succinate dehydrogenase
Sp14A_RS09675	COG0681	Belongs to the peptidase S26 family
Sp14A_RS09680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Sp14A_RS09690	COG1882	Formate acetyltransferase
Sp14A_RS09715	COG2936	dipeptidyl-peptidase activity
Sp14A_RS09720	COG4166	transmembrane transport
Sp14A_RS09730	COG0789	Transcriptional regulator
Sp14A_RS09750	COG2081	HI0933 family
Sp14A_RS09785	COG1214	PFAM Peptidase M22, glycoprotease
Sp14A_RS09790	COG5503	Protein of unknown function (DUF1447)
Sp14A_RS09800	COG3942	CHAP domain
Sp14A_RS09805	COG0174	glutamine synthetase
Sp14A_RS09810	COG0789	Transcriptional regulator
Sp14A_RS09825	COG0126	phosphoglycerate kinase activity
Sp14A_RS09830	COG0656	L-ascorbic acid biosynthetic process
Sp14A_RS09835	COG2188	Transcriptional regulator
Sp14A_RS09870	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Sp14A_RS09905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sp14A_RS09930	COG0084	hydrolase, TatD family'
Sp14A_RS09940	COG0534	Mate efflux family protein
Sp14A_RS09960	COG1847	R3H domain protein
Sp14A_RS09960	COG1847	R3H domain protein
Sp14A_RS09970	COG0594	ribonuclease P activity
Sp14A_RS09990	COG0668	transmembrane transport
Sp14A_RS09995	COG2814	Major facilitator Superfamily
Sp14A_RS10010	COG0351	phosphomethylpyrimidine kinase
Sp14A_RS10045	COG1420	regulation of RNA biosynthetic process
Sp14A_RS10050	COG1705	Flagellar rod assembly protein muramidase FlgJ
Sp14A_RS10055	COG1876	peptidase activity
Sp14A_RS10060	COG0588	phosphoglycerate mutase activity
Sp14A_RS10100	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
Sp14A_RS10125	COG1045	serine acetyltransferase
Sp14A_RS10135	COG1185	polyribonucleotide nucleotidyltransferase activity
Sp14A_RS10140	COG0390	transport system, permease component
Sp14A_RS10145	COG4619	ABC transporter
Sp14A_RS10195	COG0242	peptide deformylase activity
Sp14A_RS10200	COG0095	Lipoate-protein ligase
Sp14A_RS10210	COG0508	dehydrogenase complex catalyzes the overall conversion of
Sp14A_RS10215	COG0022	dehydrogenase e1 component
Sp14A_RS10215	COG0508	dehydrogenase complex catalyzes the overall conversion of
Sp14A_RS10220	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Sp14A_RS10230	COG1846	Transcriptional regulator
Sp14A_RS10235	COG2176	DNA-directed DNA polymerase activity
Sp14A_RS10245	COG1268	BioY protein
Sp14A_RS10280	COG1215	transferase activity, transferring glycosyl groups
Sp14A_RS10305	COG1073	alpha beta
Sp14A_RS10325	COG1442	glycosyl transferase family 8
Sp14A_RS10335	COG0343	queuine tRNA-ribosyltransferase activity
Sp14A_RS10345	COG1597	lipid kinase activity
Sp14A_RS10350	COG3590	peptidase
Sp14A_RS10360	COG3958	Transketolase
Sp14A_RS10365	COG3959	Transketolase, thiamine diphosphate binding domain
Sp14A_RS10380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Sp14A_RS10395	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Sp14A_RS10400	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
Sp14A_RS10405	COG2188	Transcriptional regulator
Sp14A_RS10410	COG0366	Alpha amylase catalytic
Sp14A_RS10415	COG1263	PTS System
Sp14A_RS10415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Sp14A_RS10420	COG2188	Transcriptional regulator
Sp14A_RS10425	COG1929	Belongs to the glycerate kinase type-1 family
Sp14A_RS10430	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Sp14A_RS10455	COG0737	Belongs to the 5'-nucleotidase family
Sp14A_RS10470	COG1363	Peptidase, m42
Sp14A_RS10490	COG2190	(PTS) system
Sp14A_RS10490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Sp14A_RS10490	COG1263	PTS System
Sp14A_RS10495	COG1609	Transcriptional regulator
Sp14A_RS10500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Sp14A_RS10530	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Sp14A_RS10560	COG1674	ftsk spoiiie
Sp14A_RS10595	COG4974	Belongs to the 'phage' integrase family
Sp14A_RS10640	COG0433	COG0433 Predicted ATPase
Sp14A_RS10690	COG2946	Replication initiation factor
Sp14A_RS10695	COG1674	ftsk spoiiie
Sp14A_RS10835	COG2226	methyltransferase
Sp14A_RS10855	COG0166	Belongs to the GPI family
Sp14A_RS10870	COG3711	transcriptional antiterminator
Sp14A_RS10870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Sp14A_RS10880	COG3730	PTS system glucitol sorbitol-specific
Sp14A_RS10885	COG3732	PTS system glucitol sorbitol-specific
Sp14A_RS10900	COG0166	Belongs to the GPI family
Sp14A_RS10925	COG1393	Belongs to the ArsC family
Sp14A_RS10930	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Sp14A_RS10945	COG2818	Glycosylase
Sp14A_RS10960	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Sp14A_RS10980	COG1764	response to oxidative stress
Sp14A_RS10985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Sp14A_RS10990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Sp14A_RS10995	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Sp14A_RS11005	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Sp14A_RS11010	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Sp14A_RS11015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Sp14A_RS11020	COG0656	L-ascorbic acid biosynthetic process
Sp14A_RS11025	COG0583	DNA-binding transcription factor activity
Sp14A_RS11065	COG3340	Belongs to the peptidase S51 family
Sp14A_RS11095	COG2217	Heavy metal translocating P-type atpase
Sp14A_RS11110	COG0494	nUDIX hydrolase
Sp14A_RS11115	COG1668	transmembrane transport
Sp14A_RS11120	COG4152	abc transporter atp-binding protein
Sp14A_RS11125	COG1695	Transcriptional regulator
Sp14A_RS11140	COG3759	membrane
Sp14A_RS11150	COG1053	succinate dehydrogenase
Sp14A_RS11155	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Sp14A_RS11245	COG0305	Participates in initiation and elongation during chromosome replication
Sp14A_RS11265	COG1051	belongs to the nudix hydrolase family
Sp14A_RS11270	COG0537	adenosine 5'-monophosphoramidase activity
Sp14A_RS11280	COG1760	l-serine dehydratase
Sp14A_RS11285	COG1760	l-serine dehydratase
Sp14A_RS11295	COG0741	lytic transglycosylase activity
Sp14A_RS11300	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Sp14A_RS11315	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Sp14A_RS11325	COG0612	Peptidase, M16
Sp14A_RS11335	COG2501	S4 domain
Sp14A_RS11340	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Sp14A_RS11350	COG0516	GMP reductase activity
Sp14A_RS11350	COG0517	IMP dehydrogenase activity
Sp14A_RS11390	COG0436	Aminotransferase
Sp14A_RS11405	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Sp14A_RS11410	COG0488	(ABC) transporter
Sp14A_RS11445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Sp14A_RS11450	COG1475	DNA binding