locus-tag	class	description
IRE31_RS00015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IRE31_RS00020	COG1475	DNA binding
IRE31_RS00030	COG0592	DNA-directed DNA polymerase activity
IRE31_RS00185	COG3645	SOS response
IRE31_RS00190	COG4974	Belongs to the 'phage' integrase family
IRE31_RS00195	COG0012	GTP binding
IRE31_RS00205	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IRE31_RS00210	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IRE31_RS00235	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IRE31_RS00240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IRE31_RS00310	COG0756	dUTP diphosphatase activity
IRE31_RS00320	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IRE31_RS00335	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IRE31_RS00350	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IRE31_RS00350	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IRE31_RS00355	COG1832	CoA-binding protein
IRE31_RS00365	COG2855	membrane
IRE31_RS00370	COG0436	Aminotransferase
IRE31_RS00375	COG1381	Involved in DNA repair and RecF pathway recombination
IRE31_RS00385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IRE31_RS00405	COG2274	protein secretion by the type I secretion system
IRE31_RS00410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRE31_RS00420	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IRE31_RS00425	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IRE31_RS00435	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IRE31_RS00450	COG0151	Belongs to the GarS family
IRE31_RS00460	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IRE31_RS00475	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IRE31_RS00480	COG3583	domain protein
IRE31_RS00480	COG3064	Membrane
IRE31_RS00480	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IRE31_RS00495	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRE31_RS00500	COG3715	PTS system
IRE31_RS00505	COG3716	PTS system mannose fructose sorbose family IID component
IRE31_RS00515	COG2222	sugar isomerase
IRE31_RS00525	COG2514	catechol 2,3-dioxygenase activity
IRE31_RS00530	COG1937	Protein conserved in bacteria
IRE31_RS00560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IRE31_RS00565	COG0569	domain protein
IRE31_RS00575	COG1215	transferase activity, transferring glycosyl groups
IRE31_RS00595	COG5002	protein histidine kinase activity
IRE31_RS00620	COG4209	transmembrane transport
IRE31_RS00625	COG0395	ABC-type sugar transport system, permease component
IRE31_RS00635	COG1653	transport
IRE31_RS00670	COG0577	efflux transmembrane transporter activity
IRE31_RS00670	COG1136	(ABC) transporter
IRE31_RS00690	COG1695	Transcriptional regulator
IRE31_RS00715	COG0546	phosphoglycolate phosphatase activity
IRE31_RS00720	COG1760	l-serine dehydratase
IRE31_RS00725	COG1760	l-serine dehydratase
IRE31_RS00730	COG1388	LysM domain
IRE31_RS00730	COG1705	Flagellar rod assembly protein muramidase FlgJ
IRE31_RS00755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IRE31_RS00865	COG0494	nUDIX hydrolase
IRE31_RS00870	COG0445	tRNA wobble uridine modification
IRE31_RS00905	COG1214	PFAM Peptidase M22, glycoprotease
IRE31_RS00940	COG0438	transferase activity, transferring glycosyl groups
IRE31_RS00970	COG1396	sequence-specific DNA binding
IRE31_RS01005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IRE31_RS01010	COG1464	Belongs to the NlpA lipoprotein family
IRE31_RS01015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IRE31_RS01020	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IRE31_RS01040	COG2972	Histidine kinase
IRE31_RS01045	COG2207	Transcriptional regulator
IRE31_RS01045	COG4753	response regulator
IRE31_RS01055	COG1780	Probably involved in ribonucleotide reductase function
IRE31_RS01090	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IRE31_RS01090	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IRE31_RS01110	COG2818	Glycosylase
IRE31_RS01215	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IRE31_RS01220	COG0006	proline dipeptidase activity
IRE31_RS01225	COG1393	Belongs to the ArsC family
IRE31_RS01250	COG0285	dihydrofolate synthase activity
IRE31_RS01260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IRE31_RS01320	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IRE31_RS01345	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IRE31_RS01385	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IRE31_RS01400	COG0201	protein transport
IRE31_RS01410	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IRE31_RS01415	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IRE31_RS01425	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IRE31_RS01430	COG0202	RNA polymerase activity
IRE31_RS01440	COG3830	Belongs to the UPF0237 family
IRE31_RS01475	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IRE31_RS01480	COG1349	DNA-binding transcription factor activity
IRE31_RS01490	COG1447	Phosphotransferase system cellobiose-specific component IIA
IRE31_RS01495	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IRE31_RS01500	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IRE31_RS01505	COG1882	Formate acetyltransferase
IRE31_RS01555	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IRE31_RS01560	COG4589	Belongs to the CDS family
IRE31_RS01565	COG0750	zinc metalloprotease
IRE31_RS01575	COG2723	6-phospho-beta-galactosidase activity
IRE31_RS01580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IRE31_RS01595	COG1523	belongs to the glycosyl hydrolase 13 family
IRE31_RS01615	COG2176	DNA-directed DNA polymerase activity
IRE31_RS01635	COG2309	aminopeptidase activity
IRE31_RS01640	COG2261	transglycosylase associated protein
IRE31_RS01645	COG1187	pseudouridine synthase activity
IRE31_RS01650	COG3579	cysteine-type endopeptidase activity
IRE31_RS01655	COG3716	PTS system mannose fructose sorbose family IID component
IRE31_RS01660	COG3715	PTS system
IRE31_RS01670	COG1064	alcohol dehydrogenase
IRE31_RS01675	COG0561	phosphatase activity
IRE31_RS01680	COG2252	PERMEase
IRE31_RS01690	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IRE31_RS01695	COG0285	dihydrofolate synthase activity
IRE31_RS01705	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IRE31_RS01705	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IRE31_RS01715	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IRE31_RS01740	COG0386	Belongs to the glutathione peroxidase family
IRE31_RS01775	COG1028	Short-chain dehydrogenase reductase Sdr
IRE31_RS01785	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IRE31_RS01790	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRE31_RS01795	COG3715	PTS system
IRE31_RS01800	COG3716	PTS system mannose fructose sorbose family IID component
IRE31_RS01815	COG1609	Transcriptional regulator
IRE31_RS01845	COG4839	cell division protein FtsL
IRE31_RS01850	COG0768	penicillin binding
IRE31_RS01875	COG0366	Alpha amylase catalytic
IRE31_RS01880	COG4166	transmembrane transport
IRE31_RS01895	COG4464	protein tyrosine phosphatase activity
IRE31_RS01900	COG3944	biosynthesis protein
IRE31_RS01905	COG0489	protein tyrosine kinase activity
IRE31_RS01920	COG3475	LICD family
IRE31_RS01940	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IRE31_RS01945	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IRE31_RS01955	COG1088	dTDP-glucose 4,6-dehydratase activity
IRE31_RS01960	COG1091	dTDP-4-dehydrorhamnose reductase activity
IRE31_RS01970	COG4166	transmembrane transport
IRE31_RS01975	COG0366	Alpha amylase catalytic
IRE31_RS01980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IRE31_RS02005	COG0116	Belongs to the methyltransferase superfamily
IRE31_RS02015	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IRE31_RS02020	COG0745	RESPONSE REGULATOR receiver
IRE31_RS02080	COG4585	Histidine kinase
IRE31_RS02085	COG2197	response regulator
IRE31_RS02110	COG0582	viral genome integration into host DNA
IRE31_RS02120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IRE31_RS02125	COG0681	Belongs to the peptidase S26 family
IRE31_RS02150	COG1115	amino acid carrier protein
IRE31_RS02175	COG0527	aspartate kinase activity
IRE31_RS02180	COG1024	Enoyl-CoA hydratase
IRE31_RS02185	COG1846	Transcriptional regulator
IRE31_RS02195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IRE31_RS02205	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IRE31_RS02210	COG1028	Short-chain dehydrogenase reductase Sdr
IRE31_RS02215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IRE31_RS02230	COG0439	Biotin carboxylase
IRE31_RS02235	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IRE31_RS02280	COG1063	alcohol dehydrogenase
IRE31_RS02305	COG1442	glycosyl transferase family 8
IRE31_RS02310	COG1442	glycosyl transferase family 8
IRE31_RS02315	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IRE31_RS02325	COG1461	Dihydroxyacetone kinase
IRE31_RS02330	COG0028	Belongs to the TPP enzyme family
IRE31_RS02335	COG0440	acetolactate synthase activity
IRE31_RS02355	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IRE31_RS02370	COG0765	amino acid transport
IRE31_RS02390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IRE31_RS02395	COG1882	Formate acetyltransferase
IRE31_RS02455	COG1940	carbohydrate kinase activity
IRE31_RS02455	COG1846	Transcriptional regulator
IRE31_RS02460	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IRE31_RS02470	COG1447	Phosphotransferase system cellobiose-specific component IIA
IRE31_RS02475	COG2723	6-phospho-beta-galactosidase activity
IRE31_RS02480	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IRE31_RS02480	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IRE31_RS02485	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IRE31_RS02490	COG0569	domain protein
IRE31_RS02510	COG1122	ATPase activity
IRE31_RS02525	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
IRE31_RS02530	COG0671	phosphoesterase, PA-phosphatase related
IRE31_RS02540	COG1247	-acetyltransferase
IRE31_RS02550	COG0504	CTP synthase activity
IRE31_RS02555	COG1283	sodium-dependent phosphate transmembrane transporter activity
IRE31_RS02575	COG0789	Transcriptional regulator
IRE31_RS02580	COG0174	glutamine synthetase
IRE31_RS02600	COG4974	Belongs to the 'phage' integrase family
IRE31_RS02610	COG0732	type I restriction modification DNA specificity domain
IRE31_RS02650	COG0484	heat shock protein binding
IRE31_RS02665	COG0537	adenosine 5'-monophosphoramidase activity
IRE31_RS02670	COG1131	(ABC) transporter
IRE31_RS02675	COG4473	ABC transporter
IRE31_RS02695	COG3290	protein histidine kinase activity
IRE31_RS02710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRE31_RS02780	COG1266	CAAX protease self-immunity
IRE31_RS02800	COG0195	Participates in both transcription termination and antitermination
IRE31_RS02805	COG2740	Nucleic-acid-binding protein implicated in transcription termination
IRE31_RS02870	COG0519	Catalyzes the synthesis of GMP from XMP
IRE31_RS02880	COG0525	valine-tRNA ligase activity
IRE31_RS02910	COG3711	transcriptional antiterminator
IRE31_RS02915	COG2190	(PTS) system
IRE31_RS02915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRE31_RS02915	COG1263	PTS System
IRE31_RS02930	COG0456	acetyltransferase
IRE31_RS02935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IRE31_RS02935	COG0072	phenylalanine-tRNA ligase activity
IRE31_RS02950	COG3620	sequence-specific DNA binding
IRE31_RS02960	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IRE31_RS02970	COG1045	serine acetyltransferase
IRE31_RS02980	COG0215	cysteine-tRNA ligase activity
IRE31_RS02985	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
IRE31_RS03005	COG0577	efflux transmembrane transporter activity
IRE31_RS03010	COG1136	(ABC) transporter
IRE31_RS03015	COG0577	efflux transmembrane transporter activity
IRE31_RS03025	COG0745	RESPONSE REGULATOR receiver
IRE31_RS03030	COG5002	protein histidine kinase activity
IRE31_RS03035	COG0191	fructose-bisphosphate aldolase activity
IRE31_RS03040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IRE31_RS03045	COG0765	amino acid transport
IRE31_RS03050	COG0765	amino acid transport
IRE31_RS03055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IRE31_RS03065	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IRE31_RS03065	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IRE31_RS03105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IRE31_RS03120	COG1573	uracil-dna glycosylase
IRE31_RS03130	COG1114	Component of the transport system for branched-chain amino acids
IRE31_RS03135	COG1363	Peptidase, m42
IRE31_RS03170	COG4555	ABC transporter
IRE31_RS03190	COG1404	Belongs to the peptidase S8 family
IRE31_RS03205	COG3775	system Galactitol-specific IIC component
IRE31_RS03210	COG3250	beta-galactosidase activity
IRE31_RS03240	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IRE31_RS03260	COG0785	Cytochrome C biogenesis protein
IRE31_RS03265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRE31_RS03270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IRE31_RS03270	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IRE31_RS03275	COG4753	response regulator
IRE31_RS03275	COG2207	Transcriptional regulator
IRE31_RS03280	COG2972	Histidine kinase
IRE31_RS03290	COG3064	Membrane
IRE31_RS03295	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IRE31_RS03310	COG1940	carbohydrate kinase activity
IRE31_RS03330	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IRE31_RS03335	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
IRE31_RS03345	COG0300	oxidoreductase activity
IRE31_RS03360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IRE31_RS03370	COG1187	pseudouridine synthase activity
IRE31_RS03375	COG1217	gtp-binding protein TYPA
IRE31_RS03395	COG1136	(ABC) transporter
IRE31_RS03410	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IRE31_RS03420	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IRE31_RS03445	COG1131	(ABC) transporter
IRE31_RS03450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IRE31_RS03490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IRE31_RS03500	COG1304	FMN binding
IRE31_RS03515	COG0352	thiamine-phosphate diphosphorylase activity
IRE31_RS03525	COG4172	Belongs to the ABC transporter superfamily
IRE31_RS03535	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IRE31_RS03550	COG0352	thiamine-phosphate diphosphorylase activity
IRE31_RS03570	COG2217	Heavy metal translocating P-type atpase
IRE31_RS03575	COG0028	Belongs to the TPP enzyme family
IRE31_RS03595	COG1482	cell wall glycoprotein biosynthetic process
IRE31_RS03600	COG0733	neurotransmitter:sodium symporter activity
IRE31_RS03615	COG2081	HI0933 family
IRE31_RS03620	COG1307	EDD domain protein, DegV family
IRE31_RS03630	COG2131	deaminase
IRE31_RS03635	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IRE31_RS03675	COG0617	tRNA 3'-terminal CCA addition
IRE31_RS03675	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IRE31_RS03675	COG0517	IMP dehydrogenase activity
IRE31_RS03685	COG2884	Cell division ATP-binding protein ftsE
IRE31_RS03690	COG2177	Part of the ABC transporter FtsEX involved in
IRE31_RS03695	COG2190	(PTS) system
IRE31_RS03695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRE31_RS03695	COG1263	PTS System
IRE31_RS03705	COG0513	Belongs to the DEAD box helicase family
IRE31_RS03715	COG0167	dihydroorotate dehydrogenase activity
IRE31_RS03725	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IRE31_RS03730	COG4470	Protein conserved in bacteria
IRE31_RS03745	COG0488	(ABC) transporter
IRE31_RS03770	COG1837	Belongs to the UPF0109 family
IRE31_RS03785	COG0513	Belongs to the DEAD box helicase family
IRE31_RS03800	COG0726	polysaccharide deacetylase
IRE31_RS03805	COG0656	L-ascorbic acid biosynthetic process
IRE31_RS03830	COG0431	NADPH-dependent FMN reductase
IRE31_RS03830	COG1053	succinate dehydrogenase
IRE31_RS03830	COG3976	FMN-binding domain protein
IRE31_RS03860	COG1272	protein, Hemolysin III
IRE31_RS03875	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IRE31_RS03880	COG1393	Belongs to the ArsC family
IRE31_RS03890	COG1126	abc transporter atp-binding protein
IRE31_RS03900	COG0492	ferredoxin-NADP+ reductase activity
IRE31_RS03925	COG0561	phosphatase activity
IRE31_RS03940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IRE31_RS03945	COG0697	spore germination
IRE31_RS03950	COG2188	Transcriptional regulator
IRE31_RS03970	COG1132	(ABC) transporter
IRE31_RS03975	COG1132	(ABC) transporter
IRE31_RS03990	COG1129	ABC transporter
IRE31_RS04010	COG0826	peptidase U32
IRE31_RS04025	COG1131	(ABC) transporter
IRE31_RS04045	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IRE31_RS04055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IRE31_RS04070	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IRE31_RS04105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IRE31_RS04115	COG0647	UMP catabolic process
IRE31_RS04125	COG1393	Belongs to the ArsC family
IRE31_RS04135	COG0483	inositol monophosphate 1-phosphatase activity
IRE31_RS04140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IRE31_RS04140	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
IRE31_RS04145	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IRE31_RS04150	COG0573	inorganic phosphate transmembrane transporter activity
IRE31_RS04155	COG0581	inorganic phosphate transmembrane transporter activity
IRE31_RS04160	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IRE31_RS04165	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IRE31_RS04170	COG0704	Plays a role in the regulation of phosphate uptake
IRE31_RS04175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IRE31_RS04180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IRE31_RS04185	COG3527	Alpha-acetolactate decarboxylase
IRE31_RS04200	COG3842	ATPase activity
IRE31_RS04240	COG1131	(ABC) transporter
IRE31_RS04250	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IRE31_RS04275	COG0287	Prephenate dehydrogenase
IRE31_RS04290	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IRE31_RS04295	COG0077	Prephenate dehydratase
IRE31_RS04305	COG3475	LICD family
IRE31_RS04315	COG1215	transferase activity, transferring glycosyl groups
IRE31_RS04350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IRE31_RS04350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IRE31_RS04355	COG1132	(ABC) transporter
IRE31_RS04365	COG0402	S-adenosylhomocysteine deaminase activity
IRE31_RS04385	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IRE31_RS04410	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IRE31_RS04415	COG0716	FMN binding
IRE31_RS04420	COG1605	Chorismate mutase
IRE31_RS04420	COG0077	Prephenate dehydratase
IRE31_RS04425	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IRE31_RS04430	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IRE31_RS04455	COG1078	dGTPase activity
IRE31_RS04470	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IRE31_RS04485	COG1704	LemA family
IRE31_RS04495	COG0488	(ABC) transporter
IRE31_RS04505	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IRE31_RS04520	COG0505	Belongs to the CarA family
IRE31_RS04535	COG3475	LICD family
IRE31_RS04550	COG1063	alcohol dehydrogenase
IRE31_RS04565	COG4750	Nucleotidyl transferase
IRE31_RS04570	COG0758	DNA mediated transformation
IRE31_RS04585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IRE31_RS04590	COG2832	Protein of unknown function (DUF454)
IRE31_RS04595	COG3142	Participates in the control of copper homeostasis
IRE31_RS04615	COG0473	3-isopropylmalate dehydrogenase activity
IRE31_RS04625	COG0066	3-isopropylmalate dehydratase activity
IRE31_RS04635	COG1401	restriction endodeoxyribonuclease activity
IRE31_RS04660	COG1196	nuclear chromosome segregation
IRE31_RS04665	COG0561	phosphatase activity
IRE31_RS04670	COG0561	phosphatase activity
IRE31_RS04675	COG0552	protein localization to endoplasmic reticulum
IRE31_RS04680	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IRE31_RS04685	COG1126	abc transporter atp-binding protein
IRE31_RS04690	COG0765	amino acid transport
IRE31_RS04715	COG2816	NAD+ diphosphatase activity
IRE31_RS04720	COG1827	regulation of RNA biosynthetic process
IRE31_RS04730	COG4684	Psort location CytoplasmicMembrane, score
IRE31_RS04735	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IRE31_RS04750	COG1194	a g-specific adenine glycosylase
IRE31_RS04755	COG0745	RESPONSE REGULATOR receiver
IRE31_RS04760	COG5002	protein histidine kinase activity
IRE31_RS04765	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IRE31_RS04780	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IRE31_RS04795	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IRE31_RS04800	COG3764	Sortase (surface protein transpeptidase)
IRE31_RS04820	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IRE31_RS04850	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IRE31_RS04855	COG1438	arginine binding
IRE31_RS04860	COG0497	DNA recombination
IRE31_RS04865	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IRE31_RS04915	COG3684	Belongs to the aldolase LacD family
IRE31_RS04920	COG3711	transcriptional antiterminator
IRE31_RS04935	COG2723	6-phospho-beta-galactosidase activity
IRE31_RS04950	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IRE31_RS04955	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IRE31_RS04960	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IRE31_RS04965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRE31_RS04980	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
IRE31_RS04985	COG1011	Hydrolase
IRE31_RS05000	COG1051	belongs to the nudix hydrolase family
IRE31_RS05005	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IRE31_RS05015	COG0534	Mate efflux family protein
IRE31_RS05020	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IRE31_RS05025	COG0022	dehydrogenase e1 component
IRE31_RS05030	COG0508	dehydrogenase complex catalyzes the overall conversion of
IRE31_RS05035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IRE31_RS05040	COG0095	Lipoate-protein ligase
IRE31_RS05060	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IRE31_RS05065	COG3583	domain protein
IRE31_RS05065	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IRE31_RS05120	COG0560	Phosphoserine phosphatase
IRE31_RS05125	COG0560	Phosphoserine phosphatase
IRE31_RS05135	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IRE31_RS05145	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IRE31_RS05150	COG1012	belongs to the aldehyde dehydrogenase family
IRE31_RS05155	COG1523	belongs to the glycosyl hydrolase 13 family
IRE31_RS05175	COG0488	(ABC) transporter
IRE31_RS05185	COG1307	EDD domain protein, DegV family
IRE31_RS05190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IRE31_RS05195	COG0196	riboflavin kinase activity
IRE31_RS05235	COG0280	phosphate acetyltransferase
IRE31_RS05240	COG0564	pseudouridine synthase activity
IRE31_RS05250	COG2357	RelA SpoT domain protein
IRE31_RS05260	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IRE31_RS05265	COG1104	cysteine desulfurase activity
IRE31_RS05285	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IRE31_RS05295	COG0210	DNA helicase
IRE31_RS05305	COG0024	Methionine aminopeptidase
IRE31_RS05310	COG4109	DRTGG domain
IRE31_RS05320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IRE31_RS05350	COG0438	transferase activity, transferring glycosyl groups
IRE31_RS05355	COG0438	transferase activity, transferring glycosyl groups
IRE31_RS05360	COG2151	metal-sulfur cluster biosynthetic enzyme
IRE31_RS05365	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IRE31_RS05370	COG0358	DNA primase activity
IRE31_RS05390	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IRE31_RS05395	COG0772	Belongs to the SEDS family
IRE31_RS05430	COG1597	lipid kinase activity
IRE31_RS05505	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRE31_RS05510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRE31_RS05525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IRE31_RS05535	COG0741	lytic transglycosylase activity
IRE31_RS05560	COG2890	protein-(glutamine-N5) methyltransferase activity
IRE31_RS05570	COG1435	thymidine kinase activity
IRE31_RS05575	COG1942	4-Oxalocrotonate Tautomerase
IRE31_RS05590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IRE31_RS05600	COG4708	membrane
IRE31_RS05610	COG1970	mechanosensitive ion channel activity
IRE31_RS05625	COG4509	Sortase family
IRE31_RS05635	COG0681	Belongs to the peptidase S26 family
IRE31_RS05675	COG3443	Belongs to the bacterial solute-binding protein 9 family
IRE31_RS05675	COG0803	Belongs to the bacterial solute-binding protein 9 family
IRE31_RS05680	COG0531	amino acid
IRE31_RS05685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRE31_RS05690	COG0785	Cytochrome C biogenesis protein
IRE31_RS05715	COG0584	glycerophosphoryl diester phosphodiesterase
IRE31_RS05720	COG2176	DNA-directed DNA polymerase activity
IRE31_RS05730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IRE31_RS05740	COG0494	nUDIX hydrolase
IRE31_RS05760	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IRE31_RS05785	COG4122	O-methyltransferase activity
IRE31_RS05800	COG3615	Tellurite resistance protein tehB
IRE31_RS05800	COG0500	methyltransferase
IRE31_RS05810	COG0557	exoribonuclease II activity
IRE31_RS05825	COG2814	Major facilitator Superfamily
IRE31_RS05830	COG0237	dephospho-CoA kinase activity
IRE31_RS05835	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IRE31_RS05845	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IRE31_RS05855	COG1293	RNA-binding protein homologous to eukaryotic snRNP
IRE31_RS05860	COG5263	repeat protein
IRE31_RS05860	COG4193	domain, Protein
IRE31_RS05865	COG0167	dihydroorotate dehydrogenase activity
IRE31_RS05870	COG0543	2 iron, 2 sulfur cluster binding
IRE31_RS05900	COG1131	(ABC) transporter
IRE31_RS05910	COG0658	competence protein
IRE31_RS05910	COG2333	competence protein COMEC
IRE31_RS05915	COG1555	photosystem II stabilization
IRE31_RS05915	COG1596	polysaccharide export
IRE31_RS05920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IRE31_RS05940	COG1702	phosphate starvation-inducible protein PhoH
IRE31_RS05950	COG2996	Protein conserved in bacteria
IRE31_RS05960	COG0528	UMP kinase activity
IRE31_RS05980	COG0470	DNA polymerase III
IRE31_RS05990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IRE31_RS06005	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IRE31_RS06010	COG0564	pseudouridine synthase activity
IRE31_RS06015	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IRE31_RS06020	COG0583	DNA-binding transcription factor activity
IRE31_RS06040	COG0561	phosphatase activity
IRE31_RS06045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IRE31_RS06065	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IRE31_RS06085	COG1982	Orn Lys Arg decarboxylase major
IRE31_RS06100	COG0577	efflux transmembrane transporter activity
IRE31_RS06105	COG1136	(ABC) transporter
IRE31_RS06125	COG2183	response to ionizing radiation
IRE31_RS06135	COG0701	Predicted permease
IRE31_RS06140	COG3689	TIGRFAM TIGR03943 family protein
IRE31_RS06175	COG0469	pyruvate kinase activity
IRE31_RS06195	COG1438	arginine binding
IRE31_RS06205	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IRE31_RS06275	COG1104	cysteine desulfurase activity
IRE31_RS06285	COG1674	ftsk spoiiie
IRE31_RS06285	COG0697	spore germination
IRE31_RS06290	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IRE31_RS06290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRE31_RS06290	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IRE31_RS06295	COG1105	Belongs to the carbohydrate kinase PfkB family
IRE31_RS06300	COG1349	DNA-binding transcription factor activity
IRE31_RS06315	COG0628	permease
IRE31_RS06320	COG1686	Belongs to the peptidase S11 family
IRE31_RS06325	COG0719	Fe-S assembly protein
IRE31_RS06335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IRE31_RS06340	COG0719	Fe-S assembly protein
IRE31_RS06355	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IRE31_RS06360	COG1956	GAF domain-containing protein
IRE31_RS06365	COG0539	negative regulation of cytoplasmic translation
IRE31_RS06400	COG4166	transmembrane transport
IRE31_RS06405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IRE31_RS06410	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IRE31_RS06420	COG0187	DNA topoisomerase II activity
IRE31_RS06435	COG1079	Belongs to the binding-protein-dependent transport system permease family
IRE31_RS06440	COG4603	Belongs to the binding-protein-dependent transport system permease family
IRE31_RS06445	COG3845	ABC transporter
IRE31_RS06450	COG1744	ABC transporter substrate-binding protein PnrA-like
IRE31_RS06455	COG0295	cytidine deaminase activity
IRE31_RS06465	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IRE31_RS06470	COG2813	Specifically methylates the guanine in position
IRE31_RS06515	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IRE31_RS06535	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IRE31_RS06540	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IRE31_RS06545	COG1126	abc transporter atp-binding protein
IRE31_RS06550	COG0765	amino acid transport
IRE31_RS06555	COG4703	Protein of unknown function (DUF1797)
IRE31_RS06560	COG0542	response to heat
IRE31_RS06570	COG0494	nUDIX hydrolase
IRE31_RS06600	COG0187	DNA topoisomerase II activity
IRE31_RS06610	COG0693	protein deglycase activity
IRE31_RS06615	COG0772	Belongs to the SEDS family
IRE31_RS06635	COG5002	protein histidine kinase activity
IRE31_RS06640	COG0745	RESPONSE REGULATOR receiver
IRE31_RS06665	COG1028	Short-chain dehydrogenase reductase Sdr
IRE31_RS06675	COG4989	oxidoreductase activity
IRE31_RS06695	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IRE31_RS06695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IRE31_RS06700	COG0577	efflux transmembrane transporter activity
IRE31_RS06705	COG1136	(ABC) transporter
IRE31_RS06710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRE31_RS06715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IRE31_RS06720	COG1268	BioY protein
IRE31_RS06730	COG4443	Transcriptional Coactivator p15 (PC4)
IRE31_RS06740	COG1328	CTP reductase activity
IRE31_RS06740	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IRE31_RS06775	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IRE31_RS06800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IRE31_RS06810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IRE31_RS06815	COG1126	abc transporter atp-binding protein
IRE31_RS06825	COG0457	Tetratricopeptide repeat
IRE31_RS06830	COG0628	permease
IRE31_RS06835	COG2706	6-phosphogluconolactonase activity
IRE31_RS06900	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IRE31_RS06925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IRE31_RS06930	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IRE31_RS06935	COG0626	cystathionine gamma-synthase activity
IRE31_RS06940	COG1132	(ABC) transporter
IRE31_RS06955	COG4166	transmembrane transport
IRE31_RS06960	COG2244	polysaccharide biosynthetic process
IRE31_RS06965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IRE31_RS06990	COG2827	Endonuclease containing a URI domain
IRE31_RS06995	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IRE31_RS07000	COG1098	S1 RNA binding domain
IRE31_RS07010	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IRE31_RS07015	COG0629	single-stranded DNA binding
IRE31_RS07025	COG0017	Asparaginyl-tRNA synthetase
IRE31_RS07035	COG0436	Aminotransferase
IRE31_RS07055	COG3711	transcriptional antiterminator
IRE31_RS07075	COG0242	peptide deformylase activity
IRE31_RS07080	COG0625	glutathione transferase activity
IRE31_RS07090	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IRE31_RS07095	COG0488	(ABC) transporter
IRE31_RS07100	COG0617	tRNA 3'-terminal CCA addition
IRE31_RS07110	COG1307	EDD domain protein, DegV family
IRE31_RS07130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IRE31_RS07140	COG1481	regulation of sporulation
IRE31_RS07145	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IRE31_RS07155	COG0251	oxidation-reduction process
IRE31_RS07175	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IRE31_RS07185	COG4193	domain, Protein
IRE31_RS07185	COG5263	repeat protein
IRE31_RS07195	COG3935	DnaD domain protein
IRE31_RS07210	COG2226	methyltransferase
IRE31_RS07220	COG3842	ATPase activity
IRE31_RS07230	COG1335	isochorismatase
IRE31_RS07240	COG0513	Belongs to the DEAD box helicase family
IRE31_RS07245	COG2223	nitrite transmembrane transporter activity
IRE31_RS07250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IRE31_RS07255	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IRE31_RS07260	COG3442	glutamine amidotransferase
IRE31_RS07265	COG0006	proline dipeptidase activity
IRE31_RS07280	COG4720	Psort location CytoplasmicMembrane, score
IRE31_RS07285	COG0351	phosphomethylpyrimidine kinase
IRE31_RS07305	COG2824	Alkylphosphonate utilization operon protein PhnA
IRE31_RS07325	COG0463	Glycosyl transferase, family 2
IRE31_RS07330	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IRE31_RS07340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IRE31_RS07345	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IRE31_RS07350	COG2384	SAM-dependent methyltransferase
IRE31_RS07370	COG2801	Transposase and inactivated derivatives
IRE31_RS07375	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IRE31_RS07380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IRE31_RS07385	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IRE31_RS07385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IRE31_RS07385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IRE31_RS07390	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IRE31_RS07410	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IRE31_RS07415	COG0204	Acyl-transferase
IRE31_RS07430	COG2910	NAD(P)H-binding
IRE31_RS07455	COG5002	protein histidine kinase activity
IRE31_RS07460	COG0745	RESPONSE REGULATOR receiver
IRE31_RS07475	COG1959	2 iron, 2 sulfur cluster binding
IRE31_RS07535	COG3590	peptidase
IRE31_RS07550	COG0803	Belongs to the bacterial solute-binding protein 9 family
IRE31_RS07555	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IRE31_RS07565	COG1136	(ABC) transporter
IRE31_RS07565	COG0577	efflux transmembrane transporter activity
IRE31_RS07595	COG3599	regulation of cell shape
IRE31_RS07615	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IRE31_RS07635	COG1051	belongs to the nudix hydrolase family
IRE31_RS07640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IRE31_RS07655	COG0768	penicillin binding
IRE31_RS07670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IRE31_RS07690	COG2731	YhcH YjgK YiaL family protein
IRE31_RS07695	COG0395	ABC-type sugar transport system, permease component
IRE31_RS07700	COG1175	transmembrane transport
IRE31_RS07710	COG2190	(PTS) system
IRE31_RS07710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRE31_RS07710	COG1263	PTS System
IRE31_RS07720	COG0673	inositol 2-dehydrogenase activity
IRE31_RS07725	COG4409	exo-alpha-(2->6)-sialidase activity
IRE31_RS07735	COG1175	transmembrane transport
IRE31_RS07740	COG1653	transport
IRE31_RS07765	COG3458	cephalosporin-C deacetylase activity
IRE31_RS07770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IRE31_RS07785	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IRE31_RS07790	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IRE31_RS07805	COG1131	(ABC) transporter
IRE31_RS07835	COG0778	Nitroreductase
IRE31_RS07840	COG1484	DNA-dependent DNA replication
IRE31_RS07855	COG1725	Transcriptional regulator
IRE31_RS07860	COG1131	(ABC) transporter
IRE31_RS07870	COG1668	transmembrane transport
IRE31_RS07875	COG4152	abc transporter atp-binding protein
IRE31_RS07895	COG1940	carbohydrate kinase activity
IRE31_RS07900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRE31_RS07900	COG2190	(PTS) system
IRE31_RS07900	COG1263	PTS System
IRE31_RS07905	COG1621	beta-fructofuranosidase activity
IRE31_RS07910	COG1609	Transcriptional regulator
IRE31_RS07920	COG3425	synthase
IRE31_RS07945	COG2815	serine threonine protein kinase
IRE31_RS07945	COG0515	serine threonine protein kinase
IRE31_RS07950	COG0631	protein serine/threonine phosphatase activity
IRE31_RS07955	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IRE31_RS07955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IRE31_RS07965	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IRE31_RS07975	COG0194	GDP metabolic process
IRE31_RS07995	COG2226	methyltransferase
IRE31_RS08000	COG0799	negative regulation of ribosome biogenesis
IRE31_RS08010	COG1713	HD superfamily hydrolase involved in NAD metabolism
IRE31_RS08015	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IRE31_RS08020	COG1534	Rna-binding protein
IRE31_RS08025	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IRE31_RS08040	COG0668	transmembrane transport
IRE31_RS08065	COG3118	belongs to the thioredoxin family
IRE31_RS08070	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IRE31_RS08080	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IRE31_RS08090	COG1164	Oligoendopeptidase f
IRE31_RS08095	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IRE31_RS08155	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IRE31_RS08165	COG1621	beta-fructofuranosidase activity
IRE31_RS08170	COG1653	transport
IRE31_RS08175	COG0395	ABC-type sugar transport system, permease component
IRE31_RS08180	COG4209	transmembrane transport
IRE31_RS08190	COG3711	transcriptional antiterminator
IRE31_RS08195	COG2261	transglycosylase associated protein
IRE31_RS08215	COG3237	CsbD-like
IRE31_RS08230	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IRE31_RS08275	COG0512	Glutamine amidotransferase of anthranilate synthase
IRE31_RS08280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IRE31_RS08300	COG1285	pathogenesis
IRE31_RS08305	COG1178	ABC-type Fe3 transport system permease component
IRE31_RS08325	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IRE31_RS08330	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
IRE31_RS08335	COG0704	Plays a role in the regulation of phosphate uptake
IRE31_RS08345	COG5434	Belongs to the glycosyl hydrolase 28 family
IRE31_RS08350	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IRE31_RS08355	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IRE31_RS08360	COG1132	(ABC) transporter
IRE31_RS08365	COG1132	(ABC) transporter
IRE31_RS08380	COG0708	Exodeoxyribonuclease III
IRE31_RS08400	COG2233	PERMEase
IRE31_RS08425	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IRE31_RS08430	COG1609	Transcriptional regulator
IRE31_RS08435	COG1063	alcohol dehydrogenase
IRE31_RS08440	COG0789	Transcriptional regulator
IRE31_RS08445	COG1230	cation diffusion facilitator family transporter
IRE31_RS08455	COG3201	nicotinamide mononucleotide transporter
IRE31_RS08460	COG1174	glycine betaine transport
IRE31_RS08485	COG1363	Peptidase, m42
IRE31_RS08500	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRE31_RS08505	COG4605	iron ion homeostasis
IRE31_RS08510	COG4604	ABC transporter, ATP-binding protein
IRE31_RS08515	COG4607	ABC-type enterochelin transport system periplasmic component
IRE31_RS08525	COG1187	pseudouridine synthase activity
IRE31_RS08545	COG0517	IMP dehydrogenase activity
IRE31_RS08555	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IRE31_RS08570	COG0366	Alpha amylase catalytic
IRE31_RS08575	COG1263	PTS System
IRE31_RS08575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRE31_RS08580	COG2188	Transcriptional regulator
IRE31_RS08600	COG4608	Belongs to the ABC transporter superfamily
IRE31_RS08605	COG0444	Belongs to the ABC transporter superfamily
IRE31_RS08610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IRE31_RS08615	COG0601	transmembrane transport
IRE31_RS08620	COG4166	transmembrane transport
IRE31_RS08630	COG0366	Alpha amylase catalytic
IRE31_RS08640	COG0395	ABC-type sugar transport system, permease component
IRE31_RS08645	COG1175	transmembrane transport
IRE31_RS08650	COG1653	transport
IRE31_RS08655	COG3345	alpha-galactosidase
IRE31_RS08660	COG2207	Transcriptional regulator
IRE31_RS08665	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IRE31_RS08665	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IRE31_RS08780	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IRE31_RS08830	COG4221	oxidoreductase activity
IRE31_RS08835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IRE31_RS08840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRE31_RS08880	COG1132	(ABC) transporter
IRE31_RS08935	COG3842	ATPase activity
IRE31_RS08940	COG1178	ABC-type Fe3 transport system permease component
IRE31_RS08945	COG1285	pathogenesis
IRE31_RS09005	COG5263	repeat protein
IRE31_RS09005	COG5632	N-Acetylmuramoyl-L-alanine amidase
IRE31_RS09025	COG1316	TRANSCRIPTIONal
IRE31_RS09035	COG0802	atpase or kinase
IRE31_RS09065	COG1674	ftsk spoiiie
IRE31_RS09075	COG2946	Replication initiation factor
IRE31_RS09125	COG0791	NLP P60 protein
IRE31_RS09125	COG0741	lytic transglycosylase activity
IRE31_RS09165	COG0488	(ABC) transporter
IRE31_RS09220	COG1136	(ABC) transporter
IRE31_RS09220	COG0577	efflux transmembrane transporter activity
IRE31_RS09245	COG1253	flavin adenine dinucleotide binding
IRE31_RS09260	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IRE31_RS09270	COG3480	Lon protease (S16) C-terminal proteolytic domain
IRE31_RS09280	COG0742	ribosomal rna small subunit methyltransferase
IRE31_RS09295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IRE31_RS09300	COG1254	Belongs to the acylphosphatase family
IRE31_RS09310	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IRE31_RS09320	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IRE31_RS09335	COG1564	THIamine pyrophosphokinase
IRE31_RS09345	COG1162	GTPase activity
IRE31_RS09375	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
IRE31_RS09380	COG0084	hydrolase, TatD family'
IRE31_RS09395	COG0436	Aminotransferase
IRE31_RS09405	COG0589	response to stress
IRE31_RS09410	COG0561	phosphatase activity
IRE31_RS09415	COG0252	asparaginase activity
IRE31_RS09425	COG1609	Transcriptional regulator
IRE31_RS09430	COG2197	response regulator
IRE31_RS09435	COG4585	Histidine kinase
IRE31_RS09440	COG0842	Transport permease protein
IRE31_RS09445	COG1131	(ABC) transporter
IRE31_RS09550	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IRE31_RS09555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IRE31_RS09560	COG0564	pseudouridine synthase activity
IRE31_RS09570	COG0577	efflux transmembrane transporter activity
IRE31_RS09580	COG0157	Belongs to the NadC ModD family
IRE31_RS09595	COG1129	ABC transporter
IRE31_RS09600	COG2188	Transcriptional regulator
IRE31_RS09605	COG2723	6-phospho-beta-galactosidase activity
IRE31_RS09610	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IRE31_RS09620	COG1447	Phosphotransferase system cellobiose-specific component IIA
IRE31_RS09625	COG1012	belongs to the aldehyde dehydrogenase family
IRE31_RS09625	COG1454	alcohol dehydrogenase
IRE31_RS09635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IRE31_RS09645	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IRE31_RS09665	COG3623	hexulose-6-phosphate isomerase
IRE31_RS09675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRE31_RS09685	COG3037	sugar-specific permease SgaT UlaA
IRE31_RS09695	COG1847	R3H domain protein
IRE31_RS09700	COG0706	membrane insertase activity
IRE31_RS09750	COG4537	Required for transformation and DNA binding
IRE31_RS09755	COG1459	type II secretion system
IRE31_RS09760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IRE31_RS09770	COG1063	alcohol dehydrogenase
IRE31_RS09795	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
IRE31_RS09800	COG3759	membrane
IRE31_RS09815	COG0131	Imidazoleglycerol-phosphate dehydratase
IRE31_RS09815	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IRE31_RS09820	COG0534	Mate efflux family protein
IRE31_RS09935	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IRE31_RS09940	COG1132	(ABC) transporter
IRE31_RS09950	COG1132	(ABC) transporter
IRE31_RS09960	COG1438	arginine binding
IRE31_RS09980	COG0745	RESPONSE REGULATOR receiver
IRE31_RS09985	COG5002	protein histidine kinase activity
IRE31_RS09990	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IRE31_RS09995	COG0573	inorganic phosphate transmembrane transporter activity
IRE31_RS10005	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IRE31_RS10010	COG0704	Plays a role in the regulation of phosphate uptake
IRE31_RS10035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IRE31_RS10045	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IRE31_RS10060	COG0697	spore germination
IRE31_RS10065	COG4499	WXG100 protein secretion system (Wss), protein YukC
IRE31_RS10065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IRE31_RS10075	COG2217	Heavy metal translocating P-type atpase
IRE31_RS10085	COG2226	methyltransferase
IRE31_RS10095	COG0058	SHG alpha-glucan phosphorylase activity
IRE31_RS10100	COG1640	4-alpha-glucanotransferase
IRE31_RS10105	COG2182	Extracellular solute-binding protein
IRE31_RS10110	COG1175	transmembrane transport
IRE31_RS10115	COG3833	ABC-type maltose transport systems, permease component
IRE31_RS10120	COG5521	maltodextrose utilization protein MalA
IRE31_RS10125	COG1609	Transcriptional regulator
IRE31_RS10130	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IRE31_RS10165	COG1476	TRANSCRIPTIONal
IRE31_RS10190	COG1396	sequence-specific DNA binding
IRE31_RS10195	COG2151	metal-sulfur cluster biosynthetic enzyme
IRE31_RS10210	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IRE31_RS10215	COG3959	Transketolase, thiamine diphosphate binding domain
IRE31_RS10230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRE31_RS10250	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IRE31_RS10285	COG0383	alpha-mannosidase activity
IRE31_RS10295	COG3537	Alpha-1,2-mannosidase
IRE31_RS10315	COG0549	Belongs to the carbamate kinase family
IRE31_RS10320	COG1288	antiporter activity
IRE31_RS10325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IRE31_RS10335	COG3583	domain protein
IRE31_RS10335	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IRE31_RS10335	COG3064	Membrane
IRE31_RS10350	COG1454	alcohol dehydrogenase
IRE31_RS10370	COG3716	PTS system mannose fructose sorbose family IID component
IRE31_RS10380	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRE31_RS10400	COG1070	Carbohydrate kinase
IRE31_RS10410	COG0803	Belongs to the bacterial solute-binding protein 9 family
IRE31_RS10410	COG3443	Belongs to the bacterial solute-binding protein 9 family
IRE31_RS10415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IRE31_RS10420	COG1121	(ABC) transporter
IRE31_RS10425	COG1846	Transcriptional regulator
IRE31_RS10430	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
IRE31_RS10440	COG1696	Membrane protein involved in D-alanine export
IRE31_RS10455	COG2211	Major facilitator Superfamily
IRE31_RS10475	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IRE31_RS10480	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IRE31_RS10500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IRE31_RS10525	COG1755	Isoprenylcysteine carboxyl methyltransferase
IRE31_RS10530	COG5002	protein histidine kinase activity
IRE31_RS10535	COG0745	RESPONSE REGULATOR receiver
IRE31_RS10540	COG0542	response to heat
IRE31_RS10545	COG4463	regulation of RNA biosynthetic process
IRE31_RS10550	COG1116	anion transmembrane transporter activity
IRE31_RS10555	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IRE31_RS10560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IRE31_RS10580	COG0305	Participates in initiation and elongation during chromosome replication
IRE31_RS10600	COG1040	competence protein
IRE31_RS10605	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
IRE31_RS10610	COG1739	Uncharacterized protein family UPF0029
IRE31_RS10645	COG3942	CHAP domain
IRE31_RS10655	COG1792	Involved in formation and maintenance of cell shape
IRE31_RS10660	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IRE31_RS10665	COG1122	ATPase activity
IRE31_RS10670	COG1122	ATPase activity
IRE31_RS10675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IRE31_RS10685	COG0612	Peptidase, M16
IRE31_RS10690	COG0612	Peptidase, M16
IRE31_RS10695	COG2501	S4 domain
IRE31_RS10705	COG0516	GMP reductase activity
IRE31_RS10705	COG0517	IMP dehydrogenase activity
IRE31_RS10710	COG0180	Tryptophanyl-tRNA synthetase
IRE31_RS10715	COG0488	(ABC) transporter
IRE31_RS10725	COG1511	domain protein
IRE31_RS10730	COG1511	domain protein