locus-tag	class	description
L3475_RS00010	COG0592	DNA-directed DNA polymerase activity
L3475_RS00170	COG3645	SOS response
L3475_RS00175	COG4974	Belongs to the 'phage' integrase family
L3475_RS00180	COG0012	GTP binding
L3475_RS00190	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L3475_RS00195	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L3475_RS00220	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L3475_RS00225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L3475_RS00295	COG0756	dUTP diphosphatase activity
L3475_RS00305	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
L3475_RS00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L3475_RS00335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L3475_RS00335	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L3475_RS00340	COG1832	CoA-binding protein
L3475_RS00350	COG2855	membrane
L3475_RS00355	COG0436	Aminotransferase
L3475_RS00360	COG1381	Involved in DNA repair and RecF pathway recombination
L3475_RS00370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L3475_RS00390	COG2274	protein secretion by the type I secretion system
L3475_RS00395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L3475_RS00405	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L3475_RS00410	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
L3475_RS00420	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L3475_RS00435	COG0151	Belongs to the GarS family
L3475_RS00445	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L3475_RS00460	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L3475_RS00465	COG3525	Glycosyl hydrolase, family 20, catalytic domain
L3475_RS00465	COG3583	domain protein
L3475_RS00465	COG3064	Membrane
L3475_RS00480	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L3475_RS00485	COG3715	PTS system
L3475_RS00490	COG3716	PTS system mannose fructose sorbose family IID component
L3475_RS00500	COG2222	sugar isomerase
L3475_RS00510	COG2514	catechol 2,3-dioxygenase activity
L3475_RS00515	COG1937	Protein conserved in bacteria
L3475_RS00545	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L3475_RS00550	COG0569	domain protein
L3475_RS00560	COG1215	transferase activity, transferring glycosyl groups
L3475_RS00580	COG5002	protein histidine kinase activity
L3475_RS00605	COG4209	transmembrane transport
L3475_RS00610	COG0395	ABC-type sugar transport system, permease component
L3475_RS00620	COG1653	transport
L3475_RS00655	COG0577	efflux transmembrane transporter activity
L3475_RS00655	COG1136	(ABC) transporter
L3475_RS00675	COG1695	Transcriptional regulator
L3475_RS00700	COG0546	phosphoglycolate phosphatase activity
L3475_RS00705	COG1760	l-serine dehydratase
L3475_RS00710	COG1760	l-serine dehydratase
L3475_RS00715	COG1388	LysM domain
L3475_RS00715	COG1705	Flagellar rod assembly protein muramidase FlgJ
L3475_RS00740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L3475_RS00840	COG0494	nUDIX hydrolase
L3475_RS00845	COG0445	tRNA wobble uridine modification
L3475_RS00880	COG1214	PFAM Peptidase M22, glycoprotease
L3475_RS00915	COG0438	transferase activity, transferring glycosyl groups
L3475_RS00945	COG1396	sequence-specific DNA binding
L3475_RS00980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L3475_RS00985	COG1464	Belongs to the NlpA lipoprotein family
L3475_RS00990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L3475_RS00995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L3475_RS01015	COG2972	Histidine kinase
L3475_RS01020	COG4753	response regulator
L3475_RS01020	COG2207	Transcriptional regulator
L3475_RS01030	COG1780	Probably involved in ribonucleotide reductase function
L3475_RS01065	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L3475_RS01065	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L3475_RS01085	COG2818	Glycosylase
L3475_RS01190	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L3475_RS01195	COG0006	proline dipeptidase activity
L3475_RS01200	COG1393	Belongs to the ArsC family
L3475_RS01225	COG0285	dihydrofolate synthase activity
L3475_RS01235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L3475_RS01305	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L3475_RS01330	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
L3475_RS01370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
L3475_RS01385	COG0201	protein transport
L3475_RS01395	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
L3475_RS01400	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L3475_RS01410	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L3475_RS01415	COG0202	RNA polymerase activity
L3475_RS01425	COG3830	Belongs to the UPF0237 family
L3475_RS01445	COG3842	ATPase activity
L3475_RS01465	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L3475_RS01470	COG1349	DNA-binding transcription factor activity
L3475_RS01480	COG1447	Phosphotransferase system cellobiose-specific component IIA
L3475_RS01485	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L3475_RS01490	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L3475_RS01495	COG1882	Formate acetyltransferase
L3475_RS01545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L3475_RS01550	COG4589	Belongs to the CDS family
L3475_RS01555	COG0750	zinc metalloprotease
L3475_RS01565	COG2723	6-phospho-beta-galactosidase activity
L3475_RS01570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L3475_RS01580	COG1523	belongs to the glycosyl hydrolase 13 family
L3475_RS01600	COG2176	DNA-directed DNA polymerase activity
L3475_RS01620	COG2309	aminopeptidase activity
L3475_RS01625	COG2261	transglycosylase associated protein
L3475_RS01630	COG1187	pseudouridine synthase activity
L3475_RS01635	COG3579	cysteine-type endopeptidase activity
L3475_RS01640	COG3716	PTS system mannose fructose sorbose family IID component
L3475_RS01645	COG3715	PTS system
L3475_RS01655	COG1064	alcohol dehydrogenase
L3475_RS01660	COG0561	phosphatase activity
L3475_RS01665	COG2252	PERMEase
L3475_RS01675	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L3475_RS01680	COG0285	dihydrofolate synthase activity
L3475_RS01690	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L3475_RS01690	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L3475_RS01700	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L3475_RS01740	COG1674	ftsk spoiiie
L3475_RS01775	COG2723	6-phospho-beta-galactosidase activity
L3475_RS01790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L3475_RS01790	COG3711	transcriptional antiterminator
L3475_RS01805	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L3475_RS01820	COG0386	Belongs to the glutathione peroxidase family
L3475_RS01825	COG5492	domain, Protein
L3475_RS01855	COG1028	Short-chain dehydrogenase reductase Sdr
L3475_RS01865	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
L3475_RS01870	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L3475_RS01875	COG3715	PTS system
L3475_RS01880	COG3716	PTS system mannose fructose sorbose family IID component
L3475_RS01895	COG1609	Transcriptional regulator
L3475_RS01920	COG4839	cell division protein FtsL
L3475_RS01925	COG0768	penicillin binding
L3475_RS01950	COG0366	Alpha amylase catalytic
L3475_RS01955	COG4166	transmembrane transport
L3475_RS01995	COG3475	LICD family
L3475_RS02015	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L3475_RS02020	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
L3475_RS02030	COG1088	dTDP-glucose 4,6-dehydratase activity
L3475_RS02035	COG1091	dTDP-4-dehydrorhamnose reductase activity
L3475_RS02045	COG4166	transmembrane transport
L3475_RS02050	COG0366	Alpha amylase catalytic
L3475_RS02055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L3475_RS02080	COG0116	Belongs to the methyltransferase superfamily
L3475_RS02090	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
L3475_RS02095	COG0745	RESPONSE REGULATOR receiver
L3475_RS02155	COG4585	Histidine kinase
L3475_RS02160	COG2197	response regulator
L3475_RS02185	COG0582	viral genome integration into host DNA
L3475_RS02195	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L3475_RS02200	COG0681	Belongs to the peptidase S26 family
L3475_RS02225	COG1115	amino acid carrier protein
L3475_RS02250	COG0527	aspartate kinase activity
L3475_RS02255	COG1024	Enoyl-CoA hydratase
L3475_RS02260	COG1846	Transcriptional regulator
L3475_RS02270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L3475_RS02280	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L3475_RS02285	COG1028	Short-chain dehydrogenase reductase Sdr
L3475_RS02290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L3475_RS02305	COG0439	Biotin carboxylase
L3475_RS02310	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
L3475_RS02355	COG1063	alcohol dehydrogenase
L3475_RS02380	COG1442	glycosyl transferase family 8
L3475_RS02385	COG1442	glycosyl transferase family 8
L3475_RS02390	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L3475_RS02400	COG1461	Dihydroxyacetone kinase
L3475_RS02405	COG0028	Belongs to the TPP enzyme family
L3475_RS02410	COG0440	acetolactate synthase activity
L3475_RS02430	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L3475_RS02445	COG0765	amino acid transport
L3475_RS02470	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L3475_RS02475	COG1882	Formate acetyltransferase
L3475_RS02535	COG1846	Transcriptional regulator
L3475_RS02535	COG1940	carbohydrate kinase activity
L3475_RS02540	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L3475_RS02550	COG1447	Phosphotransferase system cellobiose-specific component IIA
L3475_RS02555	COG2723	6-phospho-beta-galactosidase activity
L3475_RS02560	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L3475_RS02560	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L3475_RS02565	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L3475_RS02570	COG0569	domain protein
L3475_RS02590	COG1122	ATPase activity
L3475_RS02605	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
L3475_RS02610	COG0671	phosphoesterase, PA-phosphatase related
L3475_RS02620	COG1247	-acetyltransferase
L3475_RS02635	COG0504	CTP synthase activity
L3475_RS02640	COG1283	sodium-dependent phosphate transmembrane transporter activity
L3475_RS02660	COG0789	Transcriptional regulator
L3475_RS02665	COG0174	glutamine synthetase
L3475_RS02685	COG4974	Belongs to the 'phage' integrase family
L3475_RS02695	COG0732	type I restriction modification DNA specificity domain
L3475_RS02740	COG0484	heat shock protein binding
L3475_RS02755	COG0537	adenosine 5'-monophosphoramidase activity
L3475_RS02760	COG1131	(ABC) transporter
L3475_RS02765	COG4473	ABC transporter
L3475_RS02785	COG3290	protein histidine kinase activity
L3475_RS02800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L3475_RS02870	COG1266	CAAX protease self-immunity
L3475_RS02890	COG0195	Participates in both transcription termination and antitermination
L3475_RS02895	COG2740	Nucleic-acid-binding protein implicated in transcription termination
L3475_RS02960	COG0519	Catalyzes the synthesis of GMP from XMP
L3475_RS02970	COG0525	valine-tRNA ligase activity
L3475_RS03000	COG3711	transcriptional antiterminator
L3475_RS03005	COG2190	(PTS) system
L3475_RS03005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L3475_RS03005	COG1263	PTS System
L3475_RS03020	COG0456	acetyltransferase
L3475_RS03025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L3475_RS03025	COG0072	phenylalanine-tRNA ligase activity
L3475_RS03040	COG3620	sequence-specific DNA binding
L3475_RS03050	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L3475_RS03060	COG1045	serine acetyltransferase
L3475_RS03070	COG0215	cysteine-tRNA ligase activity
L3475_RS03075	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
L3475_RS03095	COG0577	efflux transmembrane transporter activity
L3475_RS03100	COG1136	(ABC) transporter
L3475_RS03105	COG0577	efflux transmembrane transporter activity
L3475_RS03115	COG0745	RESPONSE REGULATOR receiver
L3475_RS03120	COG5002	protein histidine kinase activity
L3475_RS03125	COG0191	fructose-bisphosphate aldolase activity
L3475_RS03130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L3475_RS03135	COG0765	amino acid transport
L3475_RS03140	COG0765	amino acid transport
L3475_RS03145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L3475_RS03155	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
L3475_RS03155	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L3475_RS03195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L3475_RS03210	COG1573	uracil-dna glycosylase
L3475_RS03220	COG1114	Component of the transport system for branched-chain amino acids
L3475_RS03225	COG1363	Peptidase, m42
L3475_RS03260	COG4555	ABC transporter
L3475_RS03280	COG1404	Belongs to the peptidase S8 family
L3475_RS03295	COG3775	system Galactitol-specific IIC component
L3475_RS03300	COG3250	beta-galactosidase activity
L3475_RS03330	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
L3475_RS03350	COG0785	Cytochrome C biogenesis protein
L3475_RS03355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L3475_RS03360	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L3475_RS03360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L3475_RS03365	COG2207	Transcriptional regulator
L3475_RS03365	COG4753	response regulator
L3475_RS03370	COG2972	Histidine kinase
L3475_RS03380	COG3064	Membrane
L3475_RS03385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L3475_RS03400	COG1940	carbohydrate kinase activity
L3475_RS03420	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L3475_RS03425	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
L3475_RS03435	COG0300	oxidoreductase activity
L3475_RS03450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L3475_RS03460	COG1187	pseudouridine synthase activity
L3475_RS03465	COG1217	gtp-binding protein TYPA
L3475_RS03485	COG1136	(ABC) transporter
L3475_RS03500	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L3475_RS03510	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L3475_RS03535	COG1131	(ABC) transporter
L3475_RS03540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L3475_RS03580	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
L3475_RS03590	COG1304	FMN binding
L3475_RS03610	COG0352	thiamine-phosphate diphosphorylase activity
L3475_RS03620	COG4172	Belongs to the ABC transporter superfamily
L3475_RS03630	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L3475_RS03645	COG0352	thiamine-phosphate diphosphorylase activity
L3475_RS03665	COG2217	Heavy metal translocating P-type atpase
L3475_RS03670	COG0028	Belongs to the TPP enzyme family
L3475_RS03690	COG1482	cell wall glycoprotein biosynthetic process
L3475_RS03695	COG0733	neurotransmitter:sodium symporter activity
L3475_RS03710	COG2081	HI0933 family
L3475_RS03715	COG1307	EDD domain protein, DegV family
L3475_RS03725	COG2131	deaminase
L3475_RS03730	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
L3475_RS03770	COG0517	IMP dehydrogenase activity
L3475_RS03770	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L3475_RS03770	COG0617	tRNA 3'-terminal CCA addition
L3475_RS03780	COG2884	Cell division ATP-binding protein ftsE
L3475_RS03785	COG2177	Part of the ABC transporter FtsEX involved in
L3475_RS03790	COG2190	(PTS) system
L3475_RS03790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L3475_RS03790	COG1263	PTS System
L3475_RS03800	COG0513	Belongs to the DEAD box helicase family
L3475_RS03810	COG0167	dihydroorotate dehydrogenase activity
L3475_RS03820	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L3475_RS03825	COG4470	Protein conserved in bacteria
L3475_RS03840	COG0488	(ABC) transporter
L3475_RS03865	COG1837	Belongs to the UPF0109 family
L3475_RS03880	COG0513	Belongs to the DEAD box helicase family
L3475_RS03895	COG0726	polysaccharide deacetylase
L3475_RS03900	COG0656	L-ascorbic acid biosynthetic process
L3475_RS03925	COG3976	FMN-binding domain protein
L3475_RS03925	COG1053	succinate dehydrogenase
L3475_RS03925	COG0431	NADPH-dependent FMN reductase
L3475_RS03955	COG1272	protein, Hemolysin III
L3475_RS03970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L3475_RS03975	COG1393	Belongs to the ArsC family
L3475_RS03985	COG1126	abc transporter atp-binding protein
L3475_RS03995	COG0492	ferredoxin-NADP+ reductase activity
L3475_RS04020	COG0561	phosphatase activity
L3475_RS04035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L3475_RS04040	COG0697	spore germination
L3475_RS04045	COG2188	Transcriptional regulator
L3475_RS04065	COG1132	(ABC) transporter
L3475_RS04070	COG1132	(ABC) transporter
L3475_RS04085	COG1129	ABC transporter
L3475_RS04105	COG0826	peptidase U32
L3475_RS04120	COG1131	(ABC) transporter
L3475_RS04140	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
L3475_RS04150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L3475_RS04165	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
L3475_RS04200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L3475_RS04210	COG0647	UMP catabolic process
L3475_RS04220	COG1393	Belongs to the ArsC family
L3475_RS04230	COG0483	inositol monophosphate 1-phosphatase activity
L3475_RS04235	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
L3475_RS04235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L3475_RS04240	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L3475_RS04245	COG0573	inorganic phosphate transmembrane transporter activity
L3475_RS04250	COG0581	inorganic phosphate transmembrane transporter activity
L3475_RS04255	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L3475_RS04260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L3475_RS04265	COG0704	Plays a role in the regulation of phosphate uptake
L3475_RS04270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L3475_RS04275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L3475_RS04280	COG3527	Alpha-acetolactate decarboxylase
L3475_RS04295	COG3842	ATPase activity
L3475_RS04335	COG1131	(ABC) transporter
L3475_RS04345	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L3475_RS04370	COG0287	Prephenate dehydrogenase
L3475_RS04385	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L3475_RS04390	COG0077	Prephenate dehydratase
L3475_RS04400	COG3475	LICD family
L3475_RS04410	COG1215	transferase activity, transferring glycosyl groups
L3475_RS04445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L3475_RS04445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L3475_RS04450	COG1132	(ABC) transporter
L3475_RS04460	COG0402	S-adenosylhomocysteine deaminase activity
L3475_RS04480	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L3475_RS04505	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L3475_RS04510	COG0716	FMN binding
L3475_RS04515	COG1605	Chorismate mutase
L3475_RS04515	COG0077	Prephenate dehydratase
L3475_RS04520	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L3475_RS04525	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L3475_RS04550	COG1078	dGTPase activity
L3475_RS04565	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L3475_RS04580	COG1704	LemA family
L3475_RS04590	COG0488	(ABC) transporter
L3475_RS04600	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L3475_RS04615	COG0505	Belongs to the CarA family
L3475_RS04625	COG3475	LICD family
L3475_RS04630	COG3475	LICD family
L3475_RS04645	COG1063	alcohol dehydrogenase
L3475_RS04660	COG4750	Nucleotidyl transferase
L3475_RS04665	COG0758	DNA mediated transformation
L3475_RS04680	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L3475_RS04685	COG2832	Protein of unknown function (DUF454)
L3475_RS04690	COG3142	Participates in the control of copper homeostasis
L3475_RS04710	COG0473	3-isopropylmalate dehydrogenase activity
L3475_RS04720	COG0066	3-isopropylmalate dehydratase activity
L3475_RS04730	COG1401	restriction endodeoxyribonuclease activity
L3475_RS04755	COG1196	nuclear chromosome segregation
L3475_RS04760	COG0561	phosphatase activity
L3475_RS04765	COG0561	phosphatase activity
L3475_RS04770	COG0552	protein localization to endoplasmic reticulum
L3475_RS04775	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L3475_RS04780	COG1126	abc transporter atp-binding protein
L3475_RS04785	COG0765	amino acid transport
L3475_RS04810	COG2816	NAD+ diphosphatase activity
L3475_RS04815	COG1827	regulation of RNA biosynthetic process
L3475_RS04825	COG4684	Psort location CytoplasmicMembrane, score
L3475_RS04830	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L3475_RS04845	COG1194	a g-specific adenine glycosylase
L3475_RS04850	COG0745	RESPONSE REGULATOR receiver
L3475_RS04855	COG5002	protein histidine kinase activity
L3475_RS04860	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L3475_RS04875	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L3475_RS04890	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L3475_RS04895	COG3764	Sortase (surface protein transpeptidase)
L3475_RS04915	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L3475_RS04945	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
L3475_RS04950	COG1438	arginine binding
L3475_RS04955	COG0497	DNA recombination
L3475_RS04960	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L3475_RS05010	COG3684	Belongs to the aldolase LacD family
L3475_RS05015	COG3711	transcriptional antiterminator
L3475_RS05030	COG2723	6-phospho-beta-galactosidase activity
L3475_RS05045	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L3475_RS05050	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L3475_RS05055	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L3475_RS05060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L3475_RS05075	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
L3475_RS05080	COG1011	Hydrolase
L3475_RS05095	COG1051	belongs to the nudix hydrolase family
L3475_RS05100	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L3475_RS05110	COG0534	Mate efflux family protein
L3475_RS05115	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L3475_RS05120	COG0022	dehydrogenase e1 component
L3475_RS05125	COG0508	dehydrogenase complex catalyzes the overall conversion of
L3475_RS05130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L3475_RS05135	COG0095	Lipoate-protein ligase
L3475_RS05155	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
L3475_RS05160	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
L3475_RS05160	COG3583	domain protein
L3475_RS05215	COG0560	Phosphoserine phosphatase
L3475_RS05220	COG0560	Phosphoserine phosphatase
L3475_RS05230	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L3475_RS05240	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L3475_RS05245	COG1012	belongs to the aldehyde dehydrogenase family
L3475_RS05250	COG1523	belongs to the glycosyl hydrolase 13 family
L3475_RS05270	COG0488	(ABC) transporter
L3475_RS05280	COG1307	EDD domain protein, DegV family
L3475_RS05285	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L3475_RS05290	COG0196	riboflavin kinase activity
L3475_RS05330	COG0280	phosphate acetyltransferase
L3475_RS05335	COG0564	pseudouridine synthase activity
L3475_RS05345	COG2357	RelA SpoT domain protein
L3475_RS05355	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L3475_RS05360	COG1104	cysteine desulfurase activity
L3475_RS05380	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L3475_RS05390	COG0210	DNA helicase
L3475_RS05400	COG0024	Methionine aminopeptidase
L3475_RS05405	COG4109	DRTGG domain
L3475_RS05415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L3475_RS05445	COG0438	transferase activity, transferring glycosyl groups
L3475_RS05450	COG0438	transferase activity, transferring glycosyl groups
L3475_RS05455	COG2151	metal-sulfur cluster biosynthetic enzyme
L3475_RS05460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L3475_RS05465	COG0358	DNA primase activity
L3475_RS05485	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
L3475_RS05490	COG0772	Belongs to the SEDS family
L3475_RS05525	COG1597	lipid kinase activity
L3475_RS05600	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L3475_RS05605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L3475_RS05625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L3475_RS05635	COG0741	lytic transglycosylase activity
L3475_RS05660	COG2890	protein-(glutamine-N5) methyltransferase activity
L3475_RS05670	COG1435	thymidine kinase activity
L3475_RS05675	COG1942	4-Oxalocrotonate Tautomerase
L3475_RS05690	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L3475_RS05700	COG4708	membrane
L3475_RS05710	COG1970	mechanosensitive ion channel activity
L3475_RS05725	COG4509	Sortase family
L3475_RS05735	COG0681	Belongs to the peptidase S26 family
L3475_RS05780	COG3443	Belongs to the bacterial solute-binding protein 9 family
L3475_RS05780	COG0803	Belongs to the bacterial solute-binding protein 9 family
L3475_RS05785	COG0531	amino acid
L3475_RS05790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L3475_RS05795	COG0785	Cytochrome C biogenesis protein
L3475_RS05820	COG0584	glycerophosphoryl diester phosphodiesterase
L3475_RS05825	COG2176	DNA-directed DNA polymerase activity
L3475_RS05835	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L3475_RS05845	COG0494	nUDIX hydrolase
L3475_RS05865	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L3475_RS05890	COG4122	O-methyltransferase activity
L3475_RS05905	COG3615	Tellurite resistance protein tehB
L3475_RS05905	COG0500	methyltransferase
L3475_RS05915	COG0557	exoribonuclease II activity
L3475_RS05930	COG2814	Major facilitator Superfamily
L3475_RS05935	COG0237	dephospho-CoA kinase activity
L3475_RS05940	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L3475_RS05950	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L3475_RS05960	COG1293	RNA-binding protein homologous to eukaryotic snRNP
L3475_RS05965	COG5263	repeat protein
L3475_RS05965	COG4193	domain, Protein
L3475_RS05970	COG0167	dihydroorotate dehydrogenase activity
L3475_RS05975	COG0543	2 iron, 2 sulfur cluster binding
L3475_RS06005	COG1131	(ABC) transporter
L3475_RS06015	COG0658	competence protein
L3475_RS06015	COG2333	competence protein COMEC
L3475_RS06020	COG1555	photosystem II stabilization
L3475_RS06020	COG1596	polysaccharide export
L3475_RS06025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L3475_RS06045	COG1702	phosphate starvation-inducible protein PhoH
L3475_RS06055	COG2996	Protein conserved in bacteria
L3475_RS06065	COG0528	UMP kinase activity
L3475_RS06085	COG0470	DNA polymerase III
L3475_RS06095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L3475_RS06110	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L3475_RS06115	COG0564	pseudouridine synthase activity
L3475_RS06120	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L3475_RS06125	COG0583	DNA-binding transcription factor activity
L3475_RS06145	COG0561	phosphatase activity
L3475_RS06150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L3475_RS06170	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
L3475_RS06190	COG1982	Orn Lys Arg decarboxylase major
L3475_RS06205	COG0577	efflux transmembrane transporter activity
L3475_RS06210	COG1136	(ABC) transporter
L3475_RS06235	COG2183	response to ionizing radiation
L3475_RS06245	COG0701	Predicted permease
L3475_RS06250	COG3689	TIGRFAM TIGR03943 family protein
L3475_RS06285	COG0469	pyruvate kinase activity
L3475_RS06305	COG1438	arginine binding
L3475_RS06315	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
L3475_RS06380	COG1104	cysteine desulfurase activity
L3475_RS06390	COG0697	spore germination
L3475_RS06390	COG1674	ftsk spoiiie
L3475_RS06395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L3475_RS06395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L3475_RS06395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L3475_RS06400	COG1105	Belongs to the carbohydrate kinase PfkB family
L3475_RS06405	COG1349	DNA-binding transcription factor activity
L3475_RS06420	COG0628	permease
L3475_RS06425	COG1686	Belongs to the peptidase S11 family
L3475_RS06430	COG0719	Fe-S assembly protein
L3475_RS06440	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L3475_RS06445	COG0719	Fe-S assembly protein
L3475_RS06460	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L3475_RS06465	COG1956	GAF domain-containing protein
L3475_RS06470	COG0539	negative regulation of cytoplasmic translation
L3475_RS06505	COG4166	transmembrane transport
L3475_RS06510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L3475_RS06515	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L3475_RS06525	COG0187	DNA topoisomerase II activity
L3475_RS06540	COG1079	Belongs to the binding-protein-dependent transport system permease family
L3475_RS06545	COG4603	Belongs to the binding-protein-dependent transport system permease family
L3475_RS06550	COG3845	ABC transporter
L3475_RS06555	COG1744	ABC transporter substrate-binding protein PnrA-like
L3475_RS06560	COG0295	cytidine deaminase activity
L3475_RS06570	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
L3475_RS06575	COG2813	Specifically methylates the guanine in position
L3475_RS06620	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
L3475_RS06640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L3475_RS06645	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L3475_RS06650	COG1126	abc transporter atp-binding protein
L3475_RS06655	COG0765	amino acid transport
L3475_RS06660	COG4703	Protein of unknown function (DUF1797)
L3475_RS06665	COG0542	response to heat
L3475_RS06675	COG0494	nUDIX hydrolase
L3475_RS06705	COG0187	DNA topoisomerase II activity
L3475_RS06715	COG0693	protein deglycase activity
L3475_RS06720	COG0772	Belongs to the SEDS family
L3475_RS06740	COG5002	protein histidine kinase activity
L3475_RS06745	COG0745	RESPONSE REGULATOR receiver
L3475_RS06770	COG1028	Short-chain dehydrogenase reductase Sdr
L3475_RS06780	COG4989	oxidoreductase activity
L3475_RS06800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L3475_RS06800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L3475_RS06805	COG0577	efflux transmembrane transporter activity
L3475_RS06810	COG1136	(ABC) transporter
L3475_RS06815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L3475_RS06820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L3475_RS06825	COG1268	BioY protein
L3475_RS06835	COG4443	Transcriptional Coactivator p15 (PC4)
L3475_RS06845	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L3475_RS06845	COG1328	CTP reductase activity
L3475_RS06880	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L3475_RS06905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L3475_RS06915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L3475_RS06920	COG1126	abc transporter atp-binding protein
L3475_RS06930	COG0457	Tetratricopeptide repeat
L3475_RS06935	COG0628	permease
L3475_RS06940	COG2706	6-phosphogluconolactonase activity
L3475_RS07005	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L3475_RS07030	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L3475_RS07035	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
L3475_RS07040	COG0626	cystathionine gamma-synthase activity
L3475_RS07045	COG1132	(ABC) transporter
L3475_RS07060	COG4166	transmembrane transport
L3475_RS07065	COG2244	polysaccharide biosynthetic process
L3475_RS07070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L3475_RS07095	COG2827	Endonuclease containing a URI domain
L3475_RS07100	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
L3475_RS07105	COG1098	S1 RNA binding domain
L3475_RS07115	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L3475_RS07120	COG0629	single-stranded DNA binding
L3475_RS07130	COG0017	Asparaginyl-tRNA synthetase
L3475_RS07140	COG0436	Aminotransferase
L3475_RS07160	COG3711	transcriptional antiterminator
L3475_RS07180	COG0242	peptide deformylase activity
L3475_RS07185	COG0625	glutathione transferase activity
L3475_RS07195	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
L3475_RS07200	COG0488	(ABC) transporter
L3475_RS07205	COG0617	tRNA 3'-terminal CCA addition
L3475_RS07215	COG1307	EDD domain protein, DegV family
L3475_RS07235	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
L3475_RS07245	COG1481	regulation of sporulation
L3475_RS07250	COG0391	Required for morphogenesis under gluconeogenic growth conditions
L3475_RS07260	COG0251	oxidation-reduction process
L3475_RS07280	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L3475_RS07290	COG5263	repeat protein
L3475_RS07290	COG4193	domain, Protein
L3475_RS07300	COG3935	DnaD domain protein
L3475_RS07315	COG2226	methyltransferase
L3475_RS07325	COG3842	ATPase activity
L3475_RS07335	COG1335	isochorismatase
L3475_RS07345	COG0513	Belongs to the DEAD box helicase family
L3475_RS07350	COG2223	nitrite transmembrane transporter activity
L3475_RS07355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L3475_RS07360	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L3475_RS07365	COG3442	glutamine amidotransferase
L3475_RS07370	COG0006	proline dipeptidase activity
L3475_RS07385	COG4720	Psort location CytoplasmicMembrane, score
L3475_RS07390	COG0351	phosphomethylpyrimidine kinase
L3475_RS07410	COG2824	Alkylphosphonate utilization operon protein PhnA
L3475_RS07430	COG0463	Glycosyl transferase, family 2
L3475_RS07435	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L3475_RS07445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L3475_RS07450	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L3475_RS07455	COG2384	SAM-dependent methyltransferase
L3475_RS07475	COG2801	Transposase and inactivated derivatives
L3475_RS07480	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L3475_RS07485	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L3475_RS07490	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L3475_RS07490	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L3475_RS07490	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L3475_RS07495	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L3475_RS07515	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L3475_RS07520	COG0204	Acyl-transferase
L3475_RS07535	COG2910	NAD(P)H-binding
L3475_RS07560	COG5002	protein histidine kinase activity
L3475_RS07565	COG0745	RESPONSE REGULATOR receiver
L3475_RS07580	COG1959	2 iron, 2 sulfur cluster binding
L3475_RS07640	COG3590	peptidase
L3475_RS07655	COG0803	Belongs to the bacterial solute-binding protein 9 family
L3475_RS07660	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
L3475_RS07670	COG0577	efflux transmembrane transporter activity
L3475_RS07670	COG1136	(ABC) transporter
L3475_RS07700	COG3599	regulation of cell shape
L3475_RS07720	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
L3475_RS07740	COG1051	belongs to the nudix hydrolase family
L3475_RS07745	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L3475_RS07760	COG0768	penicillin binding
L3475_RS07775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L3475_RS07795	COG2731	YhcH YjgK YiaL family protein
L3475_RS07800	COG0395	ABC-type sugar transport system, permease component
L3475_RS07805	COG1175	transmembrane transport
L3475_RS07815	COG1263	PTS System
L3475_RS07815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L3475_RS07815	COG2190	(PTS) system
L3475_RS07825	COG0673	inositol 2-dehydrogenase activity
L3475_RS07830	COG4409	exo-alpha-(2->6)-sialidase activity
L3475_RS07840	COG1175	transmembrane transport
L3475_RS07845	COG1653	transport
L3475_RS07870	COG3458	cephalosporin-C deacetylase activity
L3475_RS07875	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L3475_RS07890	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L3475_RS07895	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L3475_RS07910	COG1131	(ABC) transporter
L3475_RS07940	COG0778	Nitroreductase
L3475_RS07945	COG1484	DNA-dependent DNA replication
L3475_RS07960	COG1725	Transcriptional regulator
L3475_RS07965	COG1131	(ABC) transporter
L3475_RS07975	COG1668	transmembrane transport
L3475_RS07980	COG4152	abc transporter atp-binding protein
L3475_RS08000	COG1940	carbohydrate kinase activity
L3475_RS08005	COG1263	PTS System
L3475_RS08005	COG2190	(PTS) system
L3475_RS08005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L3475_RS08010	COG1621	beta-fructofuranosidase activity
L3475_RS08015	COG1609	Transcriptional regulator
L3475_RS08025	COG3425	synthase
L3475_RS08050	COG0515	serine threonine protein kinase
L3475_RS08050	COG2815	serine threonine protein kinase
L3475_RS08055	COG0631	protein serine/threonine phosphatase activity
L3475_RS08060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L3475_RS08060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L3475_RS08070	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L3475_RS08080	COG0194	GDP metabolic process
L3475_RS08100	COG2226	methyltransferase
L3475_RS08105	COG0799	negative regulation of ribosome biogenesis
L3475_RS08115	COG1713	HD superfamily hydrolase involved in NAD metabolism
L3475_RS08120	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L3475_RS08125	COG1534	Rna-binding protein
L3475_RS08130	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
L3475_RS08145	COG0668	transmembrane transport
L3475_RS08170	COG3118	belongs to the thioredoxin family
L3475_RS08175	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
L3475_RS08185	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L3475_RS08195	COG1164	Oligoendopeptidase f
L3475_RS08200	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L3475_RS08260	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L3475_RS08270	COG1621	beta-fructofuranosidase activity
L3475_RS08275	COG1653	transport
L3475_RS08280	COG0395	ABC-type sugar transport system, permease component
L3475_RS08285	COG4209	transmembrane transport
L3475_RS08295	COG3711	transcriptional antiterminator
L3475_RS08300	COG2261	transglycosylase associated protein
L3475_RS08320	COG3237	CsbD-like
L3475_RS08335	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L3475_RS08380	COG0512	Glutamine amidotransferase of anthranilate synthase
L3475_RS08385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L3475_RS08405	COG1285	pathogenesis
L3475_RS08410	COG1178	ABC-type Fe3 transport system permease component
L3475_RS08430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L3475_RS08435	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
L3475_RS08440	COG0704	Plays a role in the regulation of phosphate uptake
L3475_RS08450	COG5434	Belongs to the glycosyl hydrolase 28 family
L3475_RS08455	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L3475_RS08460	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L3475_RS08465	COG1132	(ABC) transporter
L3475_RS08470	COG1132	(ABC) transporter
L3475_RS08485	COG0708	Exodeoxyribonuclease III
L3475_RS08505	COG2233	PERMEase
L3475_RS08530	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
L3475_RS08535	COG1609	Transcriptional regulator
L3475_RS08540	COG1063	alcohol dehydrogenase
L3475_RS08545	COG0789	Transcriptional regulator
L3475_RS08550	COG1230	cation diffusion facilitator family transporter
L3475_RS08560	COG3201	nicotinamide mononucleotide transporter
L3475_RS08565	COG1174	glycine betaine transport
L3475_RS08590	COG1363	Peptidase, m42
L3475_RS08605	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L3475_RS08610	COG4605	iron ion homeostasis
L3475_RS08615	COG4604	ABC transporter, ATP-binding protein
L3475_RS08620	COG4607	ABC-type enterochelin transport system periplasmic component
L3475_RS08630	COG1187	pseudouridine synthase activity
L3475_RS08650	COG0517	IMP dehydrogenase activity
L3475_RS08660	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
L3475_RS08675	COG0366	Alpha amylase catalytic
L3475_RS08680	COG1263	PTS System
L3475_RS08680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L3475_RS08685	COG2188	Transcriptional regulator
L3475_RS08705	COG4608	Belongs to the ABC transporter superfamily
L3475_RS08710	COG0444	Belongs to the ABC transporter superfamily
L3475_RS08715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L3475_RS08720	COG0601	transmembrane transport
L3475_RS08725	COG4166	transmembrane transport
L3475_RS08735	COG0366	Alpha amylase catalytic
L3475_RS08745	COG0395	ABC-type sugar transport system, permease component
L3475_RS08750	COG1175	transmembrane transport
L3475_RS08755	COG1653	transport
L3475_RS08760	COG3345	alpha-galactosidase
L3475_RS08765	COG2207	Transcriptional regulator
L3475_RS08770	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
L3475_RS08770	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
L3475_RS08885	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L3475_RS08935	COG4221	oxidoreductase activity
L3475_RS08940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L3475_RS08945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L3475_RS08985	COG1132	(ABC) transporter
L3475_RS09040	COG3842	ATPase activity
L3475_RS09045	COG1178	ABC-type Fe3 transport system permease component
L3475_RS09050	COG1285	pathogenesis
L3475_RS09110	COG5263	repeat protein
L3475_RS09110	COG5632	N-Acetylmuramoyl-L-alanine amidase
L3475_RS09130	COG1316	TRANSCRIPTIONal
L3475_RS09140	COG0802	atpase or kinase
L3475_RS09170	COG1674	ftsk spoiiie
L3475_RS09180	COG2946	Replication initiation factor
L3475_RS09230	COG0791	NLP P60 protein
L3475_RS09230	COG0741	lytic transglycosylase activity
L3475_RS09270	COG0488	(ABC) transporter
L3475_RS09330	COG1136	(ABC) transporter
L3475_RS09330	COG0577	efflux transmembrane transporter activity
L3475_RS09355	COG1253	flavin adenine dinucleotide binding
L3475_RS09370	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L3475_RS09380	COG3480	Lon protease (S16) C-terminal proteolytic domain
L3475_RS09390	COG0742	ribosomal rna small subunit methyltransferase
L3475_RS09405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L3475_RS09410	COG1254	Belongs to the acylphosphatase family
L3475_RS09420	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L3475_RS09430	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L3475_RS09445	COG1564	THIamine pyrophosphokinase
L3475_RS09455	COG1162	GTPase activity
L3475_RS09485	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
L3475_RS09490	COG0084	hydrolase, TatD family'
L3475_RS09505	COG0436	Aminotransferase
L3475_RS09515	COG0589	response to stress
L3475_RS09520	COG0561	phosphatase activity
L3475_RS09525	COG0252	asparaginase activity
L3475_RS09535	COG1609	Transcriptional regulator
L3475_RS09540	COG2197	response regulator
L3475_RS09545	COG4585	Histidine kinase
L3475_RS09550	COG0842	Transport permease protein
L3475_RS09555	COG1131	(ABC) transporter
L3475_RS09660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L3475_RS09665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L3475_RS09670	COG0564	pseudouridine synthase activity
L3475_RS09680	COG0577	efflux transmembrane transporter activity
L3475_RS09690	COG0157	Belongs to the NadC ModD family
L3475_RS09705	COG1129	ABC transporter
L3475_RS09710	COG2188	Transcriptional regulator
L3475_RS09715	COG2723	6-phospho-beta-galactosidase activity
L3475_RS09720	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L3475_RS09730	COG1447	Phosphotransferase system cellobiose-specific component IIA
L3475_RS09735	COG1454	alcohol dehydrogenase
L3475_RS09735	COG1012	belongs to the aldehyde dehydrogenase family
L3475_RS09745	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L3475_RS09755	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L3475_RS09775	COG3623	hexulose-6-phosphate isomerase
L3475_RS09785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L3475_RS09795	COG3037	sugar-specific permease SgaT UlaA
L3475_RS09805	COG1847	R3H domain protein
L3475_RS09810	COG0706	membrane insertase activity
L3475_RS09860	COG4537	Required for transformation and DNA binding
L3475_RS09865	COG1459	type II secretion system
L3475_RS09870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L3475_RS09880	COG1063	alcohol dehydrogenase
L3475_RS09905	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
L3475_RS09910	COG3759	membrane
L3475_RS09930	COG0131	Imidazoleglycerol-phosphate dehydratase
L3475_RS09930	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L3475_RS09935	COG0534	Mate efflux family protein
L3475_RS10050	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L3475_RS10055	COG1132	(ABC) transporter
L3475_RS10065	COG1132	(ABC) transporter
L3475_RS10075	COG1438	arginine binding
L3475_RS10095	COG0745	RESPONSE REGULATOR receiver
L3475_RS10100	COG5002	protein histidine kinase activity
L3475_RS10105	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L3475_RS10110	COG0573	inorganic phosphate transmembrane transporter activity
L3475_RS10120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L3475_RS10125	COG0704	Plays a role in the regulation of phosphate uptake
L3475_RS10150	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L3475_RS10160	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L3475_RS10175	COG0697	spore germination
L3475_RS10180	COG4499	WXG100 protein secretion system (Wss), protein YukC
L3475_RS10180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L3475_RS10190	COG2217	Heavy metal translocating P-type atpase
L3475_RS10200	COG2226	methyltransferase
L3475_RS10210	COG0058	SHG alpha-glucan phosphorylase activity
L3475_RS10215	COG1640	4-alpha-glucanotransferase
L3475_RS10220	COG2182	Extracellular solute-binding protein
L3475_RS10225	COG1175	transmembrane transport
L3475_RS10230	COG3833	ABC-type maltose transport systems, permease component
L3475_RS10235	COG5521	maltodextrose utilization protein MalA
L3475_RS10240	COG1609	Transcriptional regulator
L3475_RS10245	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L3475_RS10280	COG1476	TRANSCRIPTIONal
L3475_RS10305	COG1396	sequence-specific DNA binding
L3475_RS10310	COG2151	metal-sulfur cluster biosynthetic enzyme
L3475_RS10325	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L3475_RS10330	COG3959	Transketolase, thiamine diphosphate binding domain
L3475_RS10345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L3475_RS10365	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L3475_RS10400	COG0383	alpha-mannosidase activity
L3475_RS10410	COG3537	Alpha-1,2-mannosidase
L3475_RS10430	COG0549	Belongs to the carbamate kinase family
L3475_RS10435	COG1288	antiporter activity
L3475_RS10440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L3475_RS10450	COG3064	Membrane
L3475_RS10450	COG3525	Glycosyl hydrolase, family 20, catalytic domain
L3475_RS10450	COG3583	domain protein
L3475_RS10465	COG1454	alcohol dehydrogenase
L3475_RS10485	COG3716	PTS system mannose fructose sorbose family IID component
L3475_RS10495	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L3475_RS10515	COG1070	Carbohydrate kinase
L3475_RS10525	COG3443	Belongs to the bacterial solute-binding protein 9 family
L3475_RS10525	COG0803	Belongs to the bacterial solute-binding protein 9 family
L3475_RS10530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L3475_RS10535	COG1121	(ABC) transporter
L3475_RS10540	COG1846	Transcriptional regulator
L3475_RS10545	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
L3475_RS10555	COG1696	Membrane protein involved in D-alanine export
L3475_RS10570	COG2211	Major facilitator Superfamily
L3475_RS10590	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L3475_RS10595	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L3475_RS10615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L3475_RS10635	COG1755	Isoprenylcysteine carboxyl methyltransferase
L3475_RS10640	COG5002	protein histidine kinase activity
L3475_RS10645	COG0745	RESPONSE REGULATOR receiver
L3475_RS10650	COG0542	response to heat
L3475_RS10655	COG4463	regulation of RNA biosynthetic process
L3475_RS10660	COG1116	anion transmembrane transporter activity
L3475_RS10665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L3475_RS10670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L3475_RS10690	COG0305	Participates in initiation and elongation during chromosome replication
L3475_RS10710	COG1040	competence protein
L3475_RS10715	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
L3475_RS10720	COG1739	Uncharacterized protein family UPF0029
L3475_RS10755	COG3942	CHAP domain
L3475_RS10765	COG1792	Involved in formation and maintenance of cell shape
L3475_RS10770	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
L3475_RS10775	COG1122	ATPase activity
L3475_RS10780	COG1122	ATPase activity
L3475_RS10785	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L3475_RS10795	COG0612	Peptidase, M16
L3475_RS10800	COG0612	Peptidase, M16
L3475_RS10805	COG2501	S4 domain
L3475_RS10815	COG0516	GMP reductase activity
L3475_RS10815	COG0517	IMP dehydrogenase activity
L3475_RS10820	COG0180	Tryptophanyl-tRNA synthetase
L3475_RS10825	COG0488	(ABC) transporter
L3475_RS10835	COG1511	domain protein
L3475_RS10840	COG1511	domain protein
L3475_RS10885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L3475_RS10890	COG1475	DNA binding