locus-tag	class	description
GL183_RS00010	COG0592	DNA-directed DNA polymerase activity
GL183_RS00020	COG1475	DNA binding
GL183_RS00025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GL183_RS00070	COG1511	domain protein
GL183_RS00080	COG1511	domain protein
GL183_RS00090	COG0488	(ABC) transporter
GL183_RS00095	COG0180	Tryptophanyl-tRNA synthetase
GL183_RS00100	COG0517	IMP dehydrogenase activity
GL183_RS00100	COG0516	GMP reductase activity
GL183_RS00110	COG2501	S4 domain
GL183_RS00115	COG0612	Peptidase, M16
GL183_RS00120	COG0612	Peptidase, M16
GL183_RS00130	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GL183_RS00135	COG1122	ATPase activity
GL183_RS00140	COG1122	ATPase activity
GL183_RS00145	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GL183_RS00150	COG1792	Involved in formation and maintenance of cell shape
GL183_RS00160	COG3942	CHAP domain
GL183_RS00195	COG1739	Uncharacterized protein family UPF0029
GL183_RS00200	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GL183_RS00205	COG1040	competence protein
GL183_RS00225	COG0305	Participates in initiation and elongation during chromosome replication
GL183_RS00245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GL183_RS00250	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GL183_RS00255	COG1116	anion transmembrane transporter activity
GL183_RS00260	COG4463	regulation of RNA biosynthetic process
GL183_RS00265	COG0542	response to heat
GL183_RS00270	COG0745	RESPONSE REGULATOR receiver
GL183_RS00275	COG5002	protein histidine kinase activity
GL183_RS00280	COG1755	Isoprenylcysteine carboxyl methyltransferase
GL183_RS00290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GL183_RS00310	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GL183_RS00315	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GL183_RS00335	COG2211	Major facilitator Superfamily
GL183_RS00350	COG1696	Membrane protein involved in D-alanine export
GL183_RS00360	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GL183_RS00365	COG1846	Transcriptional regulator
GL183_RS00370	COG1121	(ABC) transporter
GL183_RS00375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GL183_RS00380	COG3443	Belongs to the bacterial solute-binding protein 9 family
GL183_RS00380	COG0803	Belongs to the bacterial solute-binding protein 9 family
GL183_RS00390	COG1070	Carbohydrate kinase
GL183_RS00410	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GL183_RS00420	COG3716	PTS system mannose fructose sorbose family IID component
GL183_RS00440	COG1454	alcohol dehydrogenase
GL183_RS00465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GL183_RS00470	COG1288	antiporter activity
GL183_RS00475	COG0549	Belongs to the carbamate kinase family
GL183_RS00495	COG3537	Alpha-1,2-mannosidase
GL183_RS00505	COG0383	alpha-mannosidase activity
GL183_RS00540	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GL183_RS00560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GL183_RS00575	COG3959	Transketolase, thiamine diphosphate binding domain
GL183_RS00580	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GL183_RS00595	COG2151	metal-sulfur cluster biosynthetic enzyme
GL183_RS00625	COG1476	TRANSCRIPTIONal
GL183_RS00665	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GL183_RS00675	COG1609	Transcriptional regulator
GL183_RS00680	COG5521	maltodextrose utilization protein MalA
GL183_RS00685	COG3833	ABC-type maltose transport systems, permease component
GL183_RS00690	COG1175	transmembrane transport
GL183_RS00695	COG2182	Extracellular solute-binding protein
GL183_RS00700	COG1640	4-alpha-glucanotransferase
GL183_RS00705	COG0058	SHG alpha-glucan phosphorylase activity
GL183_RS00715	COG2226	methyltransferase
GL183_RS00725	COG2217	Heavy metal translocating P-type atpase
GL183_RS00735	COG4499	WXG100 protein secretion system (Wss), protein YukC
GL183_RS00735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GL183_RS00740	COG0697	spore germination
GL183_RS00755	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GL183_RS00765	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GL183_RS00785	COG0704	Plays a role in the regulation of phosphate uptake
GL183_RS00790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GL183_RS00800	COG0573	inorganic phosphate transmembrane transporter activity
GL183_RS00805	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GL183_RS00810	COG5002	protein histidine kinase activity
GL183_RS00815	COG0745	RESPONSE REGULATOR receiver
GL183_RS00840	COG1438	arginine binding
GL183_RS00850	COG1132	(ABC) transporter
GL183_RS00860	COG1132	(ABC) transporter
GL183_RS00865	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GL183_RS00980	COG0534	Mate efflux family protein
GL183_RS00985	COG0131	Imidazoleglycerol-phosphate dehydratase
GL183_RS00985	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GL183_RS01000	COG3759	membrane
GL183_RS01005	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GL183_RS01030	COG1063	alcohol dehydrogenase
GL183_RS01040	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GL183_RS01045	COG1459	type II secretion system
GL183_RS01050	COG4537	Required for transformation and DNA binding
GL183_RS01075	COG2226	methyltransferase
GL183_RS01095	COG0706	membrane insertase activity
GL183_RS01100	COG1847	R3H domain protein
GL183_RS01110	COG3037	sugar-specific permease SgaT UlaA
GL183_RS01120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GL183_RS01130	COG3623	hexulose-6-phosphate isomerase
GL183_RS01150	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GL183_RS01160	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GL183_RS01170	COG1454	alcohol dehydrogenase
GL183_RS01170	COG1012	belongs to the aldehyde dehydrogenase family
GL183_RS01175	COG1447	Phosphotransferase system cellobiose-specific component IIA
GL183_RS01185	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GL183_RS01190	COG2723	6-phospho-beta-galactosidase activity
GL183_RS01195	COG2188	Transcriptional regulator
GL183_RS01200	COG1129	ABC transporter
GL183_RS01210	COG0157	Belongs to the NadC ModD family
GL183_RS01220	COG0577	efflux transmembrane transporter activity
GL183_RS01230	COG0564	pseudouridine synthase activity
GL183_RS01235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GL183_RS01240	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GL183_RS01340	COG1131	(ABC) transporter
GL183_RS01345	COG0842	Transport permease protein
GL183_RS01350	COG4585	Histidine kinase
GL183_RS01355	COG2197	response regulator
GL183_RS01360	COG1609	Transcriptional regulator
GL183_RS01365	COG0252	asparaginase activity
GL183_RS01370	COG0561	phosphatase activity
GL183_RS01375	COG0589	response to stress
GL183_RS01385	COG0436	Aminotransferase
GL183_RS01405	COG0084	hydrolase, TatD family'
GL183_RS01410	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GL183_RS01445	COG1162	GTPase activity
GL183_RS01455	COG1564	THIamine pyrophosphokinase
GL183_RS01470	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GL183_RS01480	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GL183_RS01490	COG1254	Belongs to the acylphosphatase family
GL183_RS01495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GL183_RS01510	COG0742	ribosomal rna small subunit methyltransferase
GL183_RS01520	COG3480	Lon protease (S16) C-terminal proteolytic domain
GL183_RS01530	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GL183_RS01545	COG1253	flavin adenine dinucleotide binding
GL183_RS01570	COG0577	efflux transmembrane transporter activity
GL183_RS01570	COG1136	(ABC) transporter
GL183_RS01595	COG0802	atpase or kinase
GL183_RS01605	COG1316	TRANSCRIPTIONal
GL183_RS01625	COG5632	N-Acetylmuramoyl-L-alanine amidase
GL183_RS01625	COG5263	repeat protein
GL183_RS01710	COG1132	(ABC) transporter
GL183_RS01715	COG1132	(ABC) transporter
GL183_RS01755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GL183_RS01760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GL183_RS01765	COG4221	oxidoreductase activity
GL183_RS01805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GL183_RS01925	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GL183_RS01925	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GL183_RS01930	COG2207	Transcriptional regulator
GL183_RS01935	COG3345	alpha-galactosidase
GL183_RS01940	COG1653	transport
GL183_RS01945	COG1175	transmembrane transport
GL183_RS01950	COG0395	ABC-type sugar transport system, permease component
GL183_RS01960	COG0366	Alpha amylase catalytic
GL183_RS01975	COG4166	transmembrane transport
GL183_RS01980	COG0601	transmembrane transport
GL183_RS01985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GL183_RS01990	COG0444	Belongs to the ABC transporter superfamily
GL183_RS01995	COG4608	Belongs to the ABC transporter superfamily
GL183_RS02005	COG4120	Belongs to the binding-protein-dependent transport system permease family
GL183_RS02010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GL183_RS02015	COG2188	Transcriptional regulator
GL183_RS02020	COG1263	PTS System
GL183_RS02020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GL183_RS02025	COG0366	Alpha amylase catalytic
GL183_RS02040	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GL183_RS02050	COG0517	IMP dehydrogenase activity
GL183_RS02070	COG1187	pseudouridine synthase activity
GL183_RS02080	COG4607	ABC-type enterochelin transport system periplasmic component
GL183_RS02085	COG4604	ABC transporter, ATP-binding protein
GL183_RS02090	COG4605	iron ion homeostasis
GL183_RS02095	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GL183_RS02105	COG1363	Peptidase, m42
GL183_RS02125	COG1125	glycine betaine transport
GL183_RS02125	COG0517	IMP dehydrogenase activity
GL183_RS02130	COG1174	glycine betaine transport
GL183_RS02135	COG3201	nicotinamide mononucleotide transporter
GL183_RS02145	COG1230	cation diffusion facilitator family transporter
GL183_RS02150	COG0789	Transcriptional regulator
GL183_RS02155	COG1063	alcohol dehydrogenase
GL183_RS02160	COG1609	Transcriptional regulator
GL183_RS02165	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GL183_RS02190	COG2233	PERMEase
GL183_RS02210	COG0708	Exodeoxyribonuclease III
GL183_RS02225	COG1132	(ABC) transporter
GL183_RS02230	COG1132	(ABC) transporter
GL183_RS02235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GL183_RS02240	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GL183_RS02245	COG5434	Belongs to the glycosyl hydrolase 28 family
GL183_RS02270	COG1178	ABC-type Fe3 transport system permease component
GL183_RS02275	COG1285	pathogenesis
GL183_RS02300	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GL183_RS02305	COG0512	Glutamine amidotransferase of anthranilate synthase
GL183_RS02320	COG0135	phosphoribosylanthranilate isomerase activity
GL183_RS02360	COG1846	Transcriptional regulator
GL183_RS02360	COG1940	carbohydrate kinase activity
GL183_RS02365	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GL183_RS02375	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GL183_RS02380	COG1447	Phosphotransferase system cellobiose-specific component IIA
GL183_RS02385	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GL183_RS02395	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GL183_RS02415	COG3237	CsbD-like
GL183_RS02435	COG2261	transglycosylase associated protein
GL183_RS02440	COG3711	transcriptional antiterminator
GL183_RS02450	COG4209	transmembrane transport
GL183_RS02455	COG0395	ABC-type sugar transport system, permease component
GL183_RS02460	COG1653	transport
GL183_RS02465	COG1621	beta-fructofuranosidase activity
GL183_RS02475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GL183_RS02510	COG1051	belongs to the nudix hydrolase family
GL183_RS02525	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GL183_RS02530	COG1164	Oligoendopeptidase f
GL183_RS02535	COG0640	Transcriptional regulator
GL183_RS02540	COG1131	(ABC) transporter
GL183_RS02555	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GL183_RS02565	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GL183_RS02570	COG3118	belongs to the thioredoxin family
GL183_RS02595	COG0668	transmembrane transport
GL183_RS02610	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GL183_RS02615	COG1534	Rna-binding protein
GL183_RS02620	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GL183_RS02625	COG1713	HD superfamily hydrolase involved in NAD metabolism
GL183_RS02635	COG0799	negative regulation of ribosome biogenesis
GL183_RS02640	COG2226	methyltransferase
GL183_RS02660	COG0194	GDP metabolic process
GL183_RS02670	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GL183_RS02680	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GL183_RS02680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GL183_RS02685	COG0631	protein serine/threonine phosphatase activity
GL183_RS02690	COG2815	serine threonine protein kinase
GL183_RS02690	COG0515	serine threonine protein kinase
GL183_RS02715	COG3425	synthase
GL183_RS02725	COG1609	Transcriptional regulator
GL183_RS02730	COG1621	beta-fructofuranosidase activity
GL183_RS02735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GL183_RS02735	COG2190	(PTS) system
GL183_RS02735	COG1263	PTS System
GL183_RS02740	COG1940	carbohydrate kinase activity
GL183_RS02760	COG4152	abc transporter atp-binding protein
GL183_RS02765	COG1668	transmembrane transport
GL183_RS02775	COG1131	(ABC) transporter
GL183_RS02780	COG1725	Transcriptional regulator
GL183_RS02795	COG1484	DNA-dependent DNA replication
GL183_RS02800	COG0778	Nitroreductase
GL183_RS02840	COG1131	(ABC) transporter
GL183_RS02850	COG0653	protein targeting
GL183_RS02855	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GL183_RS02860	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GL183_RS02875	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GL183_RS02885	COG3458	cephalosporin-C deacetylase activity
GL183_RS02910	COG1653	transport
GL183_RS02915	COG1175	transmembrane transport
GL183_RS02925	COG4409	exo-alpha-(2->6)-sialidase activity
GL183_RS02930	COG0673	inositol 2-dehydrogenase activity
GL183_RS02940	COG1263	PTS System
GL183_RS02940	COG2190	(PTS) system
GL183_RS02940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GL183_RS02950	COG1175	transmembrane transport
GL183_RS02955	COG0395	ABC-type sugar transport system, permease component
GL183_RS02960	COG2731	YhcH YjgK YiaL family protein
GL183_RS02975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GL183_RS02990	COG0768	penicillin binding
GL183_RS03005	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GL183_RS03010	COG1051	belongs to the nudix hydrolase family
GL183_RS03030	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GL183_RS03050	COG3599	regulation of cell shape
GL183_RS03080	COG1136	(ABC) transporter
GL183_RS03080	COG0577	efflux transmembrane transporter activity
GL183_RS03090	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GL183_RS03095	COG0803	Belongs to the bacterial solute-binding protein 9 family
GL183_RS03110	COG3590	peptidase
GL183_RS03155	COG1959	2 iron, 2 sulfur cluster binding
GL183_RS03170	COG0745	RESPONSE REGULATOR receiver
GL183_RS03175	COG5002	protein histidine kinase activity
GL183_RS03195	COG2910	NAD(P)H-binding
GL183_RS03210	COG0204	Acyl-transferase
GL183_RS03215	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GL183_RS03220	COG2384	SAM-dependent methyltransferase
GL183_RS03225	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GL183_RS03230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GL183_RS03240	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GL183_RS03245	COG0463	Glycosyl transferase, family 2
GL183_RS03265	COG2824	Alkylphosphonate utilization operon protein PhnA
GL183_RS03285	COG0351	phosphomethylpyrimidine kinase
GL183_RS03290	COG4720	Psort location CytoplasmicMembrane, score
GL183_RS03300	COG0006	proline dipeptidase activity
GL183_RS03305	COG3442	glutamine amidotransferase
GL183_RS03310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GL183_RS03315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GL183_RS03320	COG2223	nitrite transmembrane transporter activity
GL183_RS03325	COG0513	Belongs to the DEAD box helicase family
GL183_RS03335	COG1335	isochorismatase
GL183_RS03345	COG3842	ATPase activity
GL183_RS03355	COG2226	methyltransferase
GL183_RS03370	COG3935	DnaD domain protein
GL183_RS03380	COG4193	domain, Protein
GL183_RS03380	COG5263	repeat protein
GL183_RS03390	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GL183_RS03410	COG0251	oxidation-reduction process
GL183_RS03420	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GL183_RS03430	COG0582	viral genome integration into host DNA
GL183_RS03445	COG1396	sequence-specific DNA binding
GL183_RS03455	COG3561	AntA/AntB antirepressor
GL183_RS03505	COG0629	single-stranded DNA binding
GL183_RS03685	COG5263	repeat protein
GL183_RS03685	COG5632	N-Acetylmuramoyl-L-alanine amidase
GL183_RS03695	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GL183_RS03715	COG1307	EDD domain protein, DegV family
GL183_RS03725	COG0617	tRNA 3'-terminal CCA addition
GL183_RS03730	COG0488	(ABC) transporter
GL183_RS03735	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GL183_RS03745	COG0625	glutathione transferase activity
GL183_RS03750	COG0242	peptide deformylase activity
GL183_RS03770	COG3711	transcriptional antiterminator
GL183_RS03790	COG0436	Aminotransferase
GL183_RS03800	COG0017	Asparaginyl-tRNA synthetase
GL183_RS03810	COG0629	single-stranded DNA binding
GL183_RS03815	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GL183_RS03825	COG1098	S1 RNA binding domain
GL183_RS03830	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GL183_RS03835	COG2827	Endonuclease containing a URI domain
GL183_RS03860	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GL183_RS03865	COG2244	polysaccharide biosynthetic process
GL183_RS03870	COG4166	transmembrane transport
GL183_RS03875	COG1132	(ABC) transporter
GL183_RS03880	COG1132	(ABC) transporter
GL183_RS03885	COG0626	cystathionine gamma-synthase activity
GL183_RS03890	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GL183_RS03895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GL183_RS03920	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GL183_RS03985	COG2706	6-phosphogluconolactonase activity
GL183_RS03990	COG0628	permease
GL183_RS04005	COG1126	abc transporter atp-binding protein
GL183_RS04010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GL183_RS04020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GL183_RS04055	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GL183_RS04070	COG0513	Belongs to the DEAD box helicase family
GL183_RS04085	COG0726	polysaccharide deacetylase
GL183_RS04095	COG0656	L-ascorbic acid biosynthetic process
GL183_RS04120	COG0431	NADPH-dependent FMN reductase
GL183_RS04120	COG1053	succinate dehydrogenase
GL183_RS04120	COG3976	FMN-binding domain protein
GL183_RS04150	COG1272	protein, Hemolysin III
GL183_RS04170	COG1393	Belongs to the ArsC family
GL183_RS04180	COG1126	abc transporter atp-binding protein
GL183_RS04190	COG0492	ferredoxin-NADP+ reductase activity
GL183_RS04215	COG0561	phosphatase activity
GL183_RS04230	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GL183_RS04235	COG0697	spore germination
GL183_RS04240	COG2188	Transcriptional regulator
GL183_RS04280	COG1129	ABC transporter
GL183_RS04295	COG1132	(ABC) transporter
GL183_RS04325	COG0826	peptidase U32
GL183_RS04360	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GL183_RS04370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GL183_RS04420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GL183_RS04430	COG0647	UMP catabolic process
GL183_RS04440	COG1393	Belongs to the ArsC family
GL183_RS04450	COG0483	inositol monophosphate 1-phosphatase activity
GL183_RS04455	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GL183_RS04455	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GL183_RS04460	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GL183_RS04465	COG0573	inorganic phosphate transmembrane transporter activity
GL183_RS04470	COG0581	inorganic phosphate transmembrane transporter activity
GL183_RS04475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GL183_RS04480	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GL183_RS04485	COG0704	Plays a role in the regulation of phosphate uptake
GL183_RS04490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GL183_RS04495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GL183_RS04500	COG3527	Alpha-acetolactate decarboxylase
GL183_RS04515	COG3842	ATPase activity
GL183_RS04555	COG4555	ABC transporter
GL183_RS04565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GL183_RS04590	COG0287	Prephenate dehydrogenase
GL183_RS04605	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GL183_RS04610	COG0077	Prephenate dehydratase
GL183_RS04620	COG3475	LICD family
GL183_RS04630	COG1215	transferase activity, transferring glycosyl groups
GL183_RS04665	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GL183_RS04665	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GL183_RS04670	COG1132	(ABC) transporter
GL183_RS04680	COG0402	S-adenosylhomocysteine deaminase activity
GL183_RS04705	COG0515	serine threonine protein kinase
GL183_RS04715	COG0577	efflux transmembrane transporter activity
GL183_RS04715	COG1136	(ABC) transporter
GL183_RS04740	COG1737	Transcriptional regulator
GL183_RS04745	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GL183_RS04750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GL183_RS04755	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GL183_RS04765	COG4409	exo-alpha-(2->6)-sialidase activity
GL183_RS04770	COG0673	inositol 2-dehydrogenase activity
GL183_RS04785	COG1269	ATP hydrolysis coupled proton transport
GL183_RS04790	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GL183_RS04870	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GL183_RS04900	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GL183_RS04905	COG0716	FMN binding
GL183_RS04910	COG1605	Chorismate mutase
GL183_RS04910	COG0077	Prephenate dehydratase
GL183_RS04915	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GL183_RS04920	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GL183_RS04940	COG1078	dGTPase activity
GL183_RS04955	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GL183_RS04970	COG1704	LemA family
GL183_RS04980	COG0488	(ABC) transporter
GL183_RS04995	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GL183_RS05010	COG0505	Belongs to the CarA family
GL183_RS05020	COG3475	LICD family
GL183_RS05025	COG3475	LICD family
GL183_RS05035	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GL183_RS05040	COG1063	alcohol dehydrogenase
GL183_RS05055	COG4750	Nucleotidyl transferase
GL183_RS05060	COG0758	DNA mediated transformation
GL183_RS05070	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GL183_RS05075	COG2832	Protein of unknown function (DUF454)
GL183_RS05080	COG3142	Participates in the control of copper homeostasis
GL183_RS05100	COG0473	3-isopropylmalate dehydrogenase activity
GL183_RS05110	COG0066	3-isopropylmalate dehydratase activity
GL183_RS05120	COG1401	restriction endodeoxyribonuclease activity
GL183_RS05145	COG1196	nuclear chromosome segregation
GL183_RS05150	COG0561	phosphatase activity
GL183_RS05155	COG0561	phosphatase activity
GL183_RS05160	COG0552	protein localization to endoplasmic reticulum
GL183_RS05165	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GL183_RS05170	COG1126	abc transporter atp-binding protein
GL183_RS05175	COG0765	amino acid transport
GL183_RS05200	COG2816	NAD+ diphosphatase activity
GL183_RS05205	COG1827	regulation of RNA biosynthetic process
GL183_RS05215	COG4684	Psort location CytoplasmicMembrane, score
GL183_RS05220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GL183_RS05235	COG1194	a g-specific adenine glycosylase
GL183_RS05240	COG0745	RESPONSE REGULATOR receiver
GL183_RS05245	COG5002	protein histidine kinase activity
GL183_RS05250	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GL183_RS05280	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GL183_RS05285	COG3764	Sortase (surface protein transpeptidase)
GL183_RS05305	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GL183_RS05335	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GL183_RS05340	COG1438	arginine binding
GL183_RS05345	COG0497	DNA recombination
GL183_RS05350	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GL183_RS05405	COG3684	Belongs to the aldolase LacD family
GL183_RS05410	COG3711	transcriptional antiterminator
GL183_RS05440	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GL183_RS05445	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GL183_RS05450	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GL183_RS05455	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GL183_RS05475	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GL183_RS05480	COG1011	Hydrolase
GL183_RS05495	COG1051	belongs to the nudix hydrolase family
GL183_RS05500	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GL183_RS05510	COG0534	Mate efflux family protein
GL183_RS05515	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GL183_RS05520	COG0022	dehydrogenase e1 component
GL183_RS05525	COG0508	dehydrogenase complex catalyzes the overall conversion of
GL183_RS05530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GL183_RS05535	COG0095	Lipoate-protein ligase
GL183_RS05555	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GL183_RS05560	COG3064	Membrane
GL183_RS05565	COG3583	domain protein
GL183_RS05565	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GL183_RS05575	COG1074	ATP-dependent DNA helicase activity
GL183_RS05595	COG0582	viral genome integration into host DNA
GL183_RS05615	COG0560	Phosphoserine phosphatase
GL183_RS05620	COG0560	Phosphoserine phosphatase
GL183_RS05630	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GL183_RS05640	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GL183_RS05645	COG1012	belongs to the aldehyde dehydrogenase family
GL183_RS05650	COG1523	belongs to the glycosyl hydrolase 13 family
GL183_RS05660	COG2814	Major facilitator Superfamily
GL183_RS05670	COG0488	(ABC) transporter
GL183_RS05680	COG1307	EDD domain protein, DegV family
GL183_RS05685	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GL183_RS05690	COG0196	riboflavin kinase activity
GL183_RS05730	COG0280	phosphate acetyltransferase
GL183_RS05735	COG0564	pseudouridine synthase activity
GL183_RS05745	COG2357	RelA SpoT domain protein
GL183_RS05755	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GL183_RS05760	COG1104	cysteine desulfurase activity
GL183_RS05780	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GL183_RS05790	COG0210	DNA helicase
GL183_RS05800	COG0024	Methionine aminopeptidase
GL183_RS05805	COG4109	DRTGG domain
GL183_RS05815	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GL183_RS05840	COG0438	transferase activity, transferring glycosyl groups
GL183_RS05845	COG0438	transferase activity, transferring glycosyl groups
GL183_RS05850	COG2151	metal-sulfur cluster biosynthetic enzyme
GL183_RS05855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GL183_RS05860	COG0358	DNA primase activity
GL183_RS05865	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GL183_RS05880	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GL183_RS05885	COG0772	Belongs to the SEDS family
GL183_RS05910	COG1131	(ABC) transporter
GL183_RS05940	COG3843	relaxase mobilization nuclease domain protein
GL183_RS05960	COG0542	response to heat
GL183_RS05965	COG1396	sequence-specific DNA binding
GL183_RS05975	COG0366	Alpha amylase catalytic
GL183_RS05980	COG1597	lipid kinase activity
GL183_RS06005	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GL183_RS06055	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GL183_RS06060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GL183_RS06080	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GL183_RS06100	COG3843	relaxase mobilization nuclease domain protein
GL183_RS06130	COG0542	response to heat
GL183_RS06135	COG1396	sequence-specific DNA binding
GL183_RS06220	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GL183_RS06230	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GL183_RS06235	COG1396	sequence-specific DNA binding
GL183_RS06300	COG1674	ftsk spoiiie
GL183_RS06310	COG2946	Replication initiation factor
GL183_RS06355	COG0791	NLP P60 protein
GL183_RS06355	COG0741	lytic transglycosylase activity
GL183_RS06370	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GL183_RS06425	COG0270	DNA (cytosine-5-)-methyltransferase activity
GL183_RS06440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GL183_RS06450	COG0741	lytic transglycosylase activity
GL183_RS06475	COG2890	protein-(glutamine-N5) methyltransferase activity
GL183_RS06480	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GL183_RS06485	COG1435	thymidine kinase activity
GL183_RS06490	COG1942	4-Oxalocrotonate Tautomerase
GL183_RS06495	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GL183_RS06505	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GL183_RS06515	COG4708	membrane
GL183_RS06525	COG1970	mechanosensitive ion channel activity
GL183_RS06575	COG3443	Belongs to the bacterial solute-binding protein 9 family
GL183_RS06575	COG0803	Belongs to the bacterial solute-binding protein 9 family
GL183_RS06580	COG0531	amino acid
GL183_RS06585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GL183_RS06590	COG0785	Cytochrome C biogenesis protein
GL183_RS06610	COG0584	glycerophosphoryl diester phosphodiesterase
GL183_RS06615	COG2176	DNA-directed DNA polymerase activity
GL183_RS06625	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GL183_RS06635	COG0494	nUDIX hydrolase
GL183_RS06640	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GL183_RS06655	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GL183_RS06680	COG4122	O-methyltransferase activity
GL183_RS06695	COG3615	Tellurite resistance protein tehB
GL183_RS06695	COG0500	methyltransferase
GL183_RS06705	COG0557	exoribonuclease II activity
GL183_RS06715	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GL183_RS06720	COG2814	Major facilitator Superfamily
GL183_RS06725	COG0237	dephospho-CoA kinase activity
GL183_RS06730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GL183_RS06740	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GL183_RS06750	COG1293	RNA-binding protein homologous to eukaryotic snRNP
GL183_RS06755	COG4193	domain, Protein
GL183_RS06755	COG5263	repeat protein
GL183_RS06760	COG0167	dihydroorotate dehydrogenase activity
GL183_RS06765	COG0543	2 iron, 2 sulfur cluster binding
GL183_RS06795	COG1131	(ABC) transporter
GL183_RS06805	COG0658	competence protein
GL183_RS06805	COG2333	competence protein COMEC
GL183_RS06810	COG1596	polysaccharide export
GL183_RS06810	COG1555	photosystem II stabilization
GL183_RS06815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GL183_RS06820	COG0686	Belongs to the AlaDH PNT family
GL183_RS06825	COG0686	Belongs to the AlaDH PNT family
GL183_RS06830	COG0686	Belongs to the AlaDH PNT family
GL183_RS06850	COG1702	phosphate starvation-inducible protein PhoH
GL183_RS06860	COG2996	Protein conserved in bacteria
GL183_RS06870	COG0528	UMP kinase activity
GL183_RS06910	COG0470	DNA polymerase III
GL183_RS06920	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GL183_RS06935	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GL183_RS06940	COG0564	pseudouridine synthase activity
GL183_RS06945	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GL183_RS06950	COG0583	DNA-binding transcription factor activity
GL183_RS06970	COG0561	phosphatase activity
GL183_RS06975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GL183_RS06995	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GL183_RS07005	COG1982	Orn Lys Arg decarboxylase major
GL183_RS07020	COG0577	efflux transmembrane transporter activity
GL183_RS07025	COG1136	(ABC) transporter
GL183_RS07045	COG2183	response to ionizing radiation
GL183_RS07055	COG0701	Predicted permease
GL183_RS07060	COG3689	TIGRFAM TIGR03943 family protein
GL183_RS07090	COG0582	viral genome integration into host DNA
GL183_RS07095	COG0469	pyruvate kinase activity
GL183_RS07115	COG1438	arginine binding
GL183_RS07125	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GL183_RS07180	COG1104	cysteine desulfurase activity
GL183_RS07190	COG1674	ftsk spoiiie
GL183_RS07190	COG0697	spore germination
GL183_RS07195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GL183_RS07195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GL183_RS07195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GL183_RS07200	COG1105	Belongs to the carbohydrate kinase PfkB family
GL183_RS07205	COG1349	DNA-binding transcription factor activity
GL183_RS07220	COG0628	permease
GL183_RS07225	COG1686	Belongs to the peptidase S11 family
GL183_RS07230	COG0719	Fe-S assembly protein
GL183_RS07240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GL183_RS07245	COG0719	Fe-S assembly protein
GL183_RS07260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GL183_RS07265	COG1956	GAF domain-containing protein
GL183_RS07275	COG0539	negative regulation of cytoplasmic translation
GL183_RS07310	COG4166	transmembrane transport
GL183_RS07315	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GL183_RS07320	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GL183_RS07330	COG0187	DNA topoisomerase II activity
GL183_RS07345	COG1079	Belongs to the binding-protein-dependent transport system permease family
GL183_RS07350	COG4603	Belongs to the binding-protein-dependent transport system permease family
GL183_RS07355	COG3845	ABC transporter
GL183_RS07360	COG1744	ABC transporter substrate-binding protein PnrA-like
GL183_RS07365	COG0295	cytidine deaminase activity
GL183_RS07375	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GL183_RS07380	COG2813	Specifically methylates the guanine in position
GL183_RS07420	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GL183_RS07440	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GL183_RS07450	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GL183_RS07455	COG1126	abc transporter atp-binding protein
GL183_RS07460	COG0765	amino acid transport
GL183_RS07465	COG4703	Protein of unknown function (DUF1797)
GL183_RS07470	COG0542	response to heat
GL183_RS07480	COG0494	nUDIX hydrolase
GL183_RS07500	COG0187	DNA topoisomerase II activity
GL183_RS07510	COG0693	protein deglycase activity
GL183_RS07515	COG0772	Belongs to the SEDS family
GL183_RS07535	COG5002	protein histidine kinase activity
GL183_RS07540	COG0745	RESPONSE REGULATOR receiver
GL183_RS07575	COG1028	Short-chain dehydrogenase reductase Sdr
GL183_RS07585	COG4989	oxidoreductase activity
GL183_RS07610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GL183_RS07610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GL183_RS07615	COG0577	efflux transmembrane transporter activity
GL183_RS07620	COG1136	(ABC) transporter
GL183_RS07625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GL183_RS07630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GL183_RS07640	COG0577	efflux transmembrane transporter activity
GL183_RS07640	COG1136	(ABC) transporter
GL183_RS07655	COG1268	BioY protein
GL183_RS07665	COG4443	Transcriptional Coactivator p15 (PC4)
GL183_RS07675	COG1328	CTP reductase activity
GL183_RS07675	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GL183_RS07700	COG1837	Belongs to the UPF0109 family
GL183_RS07730	COG0488	(ABC) transporter
GL183_RS07740	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GL183_RS07745	COG4470	Protein conserved in bacteria
GL183_RS07750	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GL183_RS07760	COG0167	dihydroorotate dehydrogenase activity
GL183_RS07770	COG0513	Belongs to the DEAD box helicase family
GL183_RS07780	COG2190	(PTS) system
GL183_RS07780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GL183_RS07780	COG1263	PTS System
GL183_RS07790	COG2177	Part of the ABC transporter FtsEX involved in
GL183_RS07795	COG2884	Cell division ATP-binding protein ftsE
GL183_RS07805	COG0517	IMP dehydrogenase activity
GL183_RS07805	COG0617	tRNA 3'-terminal CCA addition
GL183_RS07805	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GL183_RS07845	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GL183_RS07850	COG2131	deaminase
GL183_RS07860	COG1307	EDD domain protein, DegV family
GL183_RS07865	COG2081	HI0933 family
GL183_RS07880	COG0733	neurotransmitter:sodium symporter activity
GL183_RS07885	COG1482	cell wall glycoprotein biosynthetic process
GL183_RS07890	COG2723	6-phospho-beta-galactosidase activity
GL183_RS07905	COG0028	Belongs to the TPP enzyme family
GL183_RS07910	COG2217	Heavy metal translocating P-type atpase
GL183_RS07930	COG0352	thiamine-phosphate diphosphorylase activity
GL183_RS07945	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GL183_RS07955	COG4172	Belongs to the ABC transporter superfamily
GL183_RS07965	COG0352	thiamine-phosphate diphosphorylase activity
GL183_RS07970	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GL183_RS07980	COG1304	FMN binding
GL183_RS07990	COG1304	FMN binding
GL183_RS07995	COG0765	amino acid transport
GL183_RS08000	COG0765	amino acid transport
GL183_RS08005	COG1126	abc transporter atp-binding protein
GL183_RS08015	COG1131	(ABC) transporter
GL183_RS08040	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GL183_RS08050	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GL183_RS08065	COG1136	(ABC) transporter
GL183_RS08085	COG1217	gtp-binding protein TYPA
GL183_RS08090	COG1187	pseudouridine synthase activity
GL183_RS08100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GL183_RS08115	COG0300	oxidoreductase activity
GL183_RS08125	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GL183_RS08130	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GL183_RS08150	COG1940	carbohydrate kinase activity
GL183_RS08165	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GL183_RS08170	COG3064	Membrane
GL183_RS08180	COG2972	Histidine kinase
GL183_RS08185	COG4753	response regulator
GL183_RS08185	COG2207	Transcriptional regulator
GL183_RS08190	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GL183_RS08190	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GL183_RS08195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GL183_RS08200	COG0785	Cytochrome C biogenesis protein
GL183_RS08220	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GL183_RS08240	COG3250	beta-galactosidase activity
GL183_RS08245	COG3775	system Galactitol-specific IIC component
GL183_RS08290	COG4555	ABC transporter
GL183_RS08330	COG1363	Peptidase, m42
GL183_RS08335	COG1114	Component of the transport system for branched-chain amino acids
GL183_RS08345	COG1573	uracil-dna glycosylase
GL183_RS08360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GL183_RS08400	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GL183_RS08400	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GL183_RS08410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GL183_RS08415	COG0765	amino acid transport
GL183_RS08420	COG0765	amino acid transport
GL183_RS08425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GL183_RS08430	COG0191	fructose-bisphosphate aldolase activity
GL183_RS08435	COG5002	protein histidine kinase activity
GL183_RS08440	COG0745	RESPONSE REGULATOR receiver
GL183_RS08445	COG0577	efflux transmembrane transporter activity
GL183_RS08450	COG1136	(ABC) transporter
GL183_RS08455	COG0577	efflux transmembrane transporter activity
GL183_RS08480	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GL183_RS08485	COG0215	cysteine-tRNA ligase activity
GL183_RS08495	COG1045	serine acetyltransferase
GL183_RS08510	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GL183_RS08515	COG3620	sequence-specific DNA binding
GL183_RS08530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GL183_RS08530	COG0072	phenylalanine-tRNA ligase activity
GL183_RS08535	COG0456	acetyltransferase
GL183_RS08550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GL183_RS08550	COG1263	PTS System
GL183_RS08550	COG2190	(PTS) system
GL183_RS08555	COG3711	transcriptional antiterminator
GL183_RS08580	COG0525	valine-tRNA ligase activity
GL183_RS08590	COG0519	Catalyzes the synthesis of GMP from XMP
GL183_RS08650	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GL183_RS08655	COG0195	Participates in both transcription termination and antitermination
GL183_RS08675	COG1266	CAAX protease self-immunity
GL183_RS08725	COG2274	protein secretion by the type I secretion system
GL183_RS08730	COG2274	protein secretion by the type I secretion system
GL183_RS08735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GL183_RS08755	COG1131	(ABC) transporter
GL183_RS08760	COG0537	adenosine 5'-monophosphoramidase activity
GL183_RS08775	COG0484	heat shock protein binding
GL183_RS08820	COG4974	Belongs to the 'phage' integrase family
GL183_RS08840	COG0174	glutamine synthetase
GL183_RS08845	COG0789	Transcriptional regulator
GL183_RS08865	COG1283	sodium-dependent phosphate transmembrane transporter activity
GL183_RS08870	COG0504	CTP synthase activity
GL183_RS08880	COG1247	-acetyltransferase
GL183_RS08890	COG0671	phosphoesterase, PA-phosphatase related
GL183_RS08895	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GL183_RS08910	COG1122	ATPase activity
GL183_RS08930	COG0569	domain protein
GL183_RS08935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GL183_RS08965	COG1882	Formate acetyltransferase
GL183_RS08970	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GL183_RS08990	COG0765	amino acid transport
GL183_RS09005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GL183_RS09025	COG0440	acetolactate synthase activity
GL183_RS09030	COG0028	Belongs to the TPP enzyme family
GL183_RS09035	COG1461	Dihydroxyacetone kinase
GL183_RS09045	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GL183_RS09055	COG1442	glycosyl transferase family 8
GL183_RS09060	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GL183_RS09115	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GL183_RS09120	COG0439	Biotin carboxylase
GL183_RS09135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GL183_RS09140	COG1028	Short-chain dehydrogenase reductase Sdr
GL183_RS09145	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GL183_RS09155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GL183_RS09165	COG1846	Transcriptional regulator
GL183_RS09170	COG1024	Enoyl-CoA hydratase
GL183_RS09175	COG0527	aspartate kinase activity
GL183_RS09185	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GL183_RS09200	COG1115	amino acid carrier protein
GL183_RS09225	COG0681	Belongs to the peptidase S26 family
GL183_RS09230	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GL183_RS09245	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GL183_RS09250	COG3711	transcriptional antiterminator
GL183_RS09255	COG2213	PTS system mannitol-specific
GL183_RS09295	COG2197	response regulator
GL183_RS09300	COG4585	Histidine kinase
GL183_RS09355	COG0745	RESPONSE REGULATOR receiver
GL183_RS09360	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GL183_RS09370	COG0116	Belongs to the methyltransferase superfamily
GL183_RS09395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GL183_RS09400	COG0366	Alpha amylase catalytic
GL183_RS09405	COG4166	transmembrane transport
GL183_RS09420	COG1091	dTDP-4-dehydrorhamnose reductase activity
GL183_RS09425	COG1088	dTDP-glucose 4,6-dehydratase activity
GL183_RS09435	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GL183_RS09455	COG3475	LICD family
GL183_RS09465	COG1215	transferase activity, transferring glycosyl groups
GL183_RS09490	COG3475	LICD family
GL183_RS09515	COG4464	protein tyrosine phosphatase activity
GL183_RS09530	COG4166	transmembrane transport
GL183_RS09535	COG0366	Alpha amylase catalytic
GL183_RS09575	COG0768	penicillin binding
GL183_RS09580	COG4839	cell division protein FtsL
GL183_RS09610	COG1609	Transcriptional regulator
GL183_RS09625	COG3716	PTS system mannose fructose sorbose family IID component
GL183_RS09630	COG3715	PTS system
GL183_RS09635	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GL183_RS09640	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GL183_RS09650	COG1028	Short-chain dehydrogenase reductase Sdr
GL183_RS09675	COG5492	domain, Protein
GL183_RS09680	COG0386	Belongs to the glutathione peroxidase family
GL183_RS09705	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GL183_RS09715	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GL183_RS09715	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GL183_RS09725	COG0285	dihydrofolate synthase activity
GL183_RS09730	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GL183_RS09740	COG2252	PERMEase
GL183_RS09745	COG0561	phosphatase activity
GL183_RS09750	COG1064	alcohol dehydrogenase
GL183_RS09760	COG3715	PTS system
GL183_RS09765	COG3716	PTS system mannose fructose sorbose family IID component
GL183_RS09770	COG3579	cysteine-type endopeptidase activity
GL183_RS09775	COG1187	pseudouridine synthase activity
GL183_RS09780	COG2261	transglycosylase associated protein
GL183_RS09785	COG2309	aminopeptidase activity
GL183_RS09805	COG2176	DNA-directed DNA polymerase activity
GL183_RS09825	COG1523	belongs to the glycosyl hydrolase 13 family
GL183_RS09835	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GL183_RS09840	COG2723	6-phospho-beta-galactosidase activity
GL183_RS09850	COG0750	zinc metalloprotease
GL183_RS09855	COG4589	Belongs to the CDS family
GL183_RS09860	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GL183_RS09905	COG1882	Formate acetyltransferase
GL183_RS09910	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GL183_RS09915	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GL183_RS09920	COG1447	Phosphotransferase system cellobiose-specific component IIA
GL183_RS09930	COG1349	DNA-binding transcription factor activity
GL183_RS09935	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GL183_RS09955	COG3842	ATPase activity
GL183_RS09975	COG3830	Belongs to the UPF0237 family
GL183_RS09985	COG0202	RNA polymerase activity
GL183_RS09990	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GL183_RS10000	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GL183_RS10005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GL183_RS10015	COG0201	protein transport
GL183_RS10030	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GL183_RS10070	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GL183_RS10095	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GL183_RS10160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GL183_RS10170	COG0285	dihydrofolate synthase activity
GL183_RS10195	COG1393	Belongs to the ArsC family
GL183_RS10200	COG0006	proline dipeptidase activity
GL183_RS10205	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GL183_RS10230	COG0519	Catalyzes the synthesis of GMP from XMP
GL183_RS10250	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GL183_RS10250	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GL183_RS10285	COG1780	Probably involved in ribonucleotide reductase function
GL183_RS10295	COG4753	response regulator
GL183_RS10295	COG2207	Transcriptional regulator
GL183_RS10300	COG2972	Histidine kinase
GL183_RS10320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GL183_RS10325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GL183_RS10330	COG1464	Belongs to the NlpA lipoprotein family
GL183_RS10335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GL183_RS10375	COG1396	sequence-specific DNA binding
GL183_RS10440	COG1214	PFAM Peptidase M22, glycoprotease
GL183_RS10475	COG0445	tRNA wobble uridine modification
GL183_RS10480	COG0494	nUDIX hydrolase
GL183_RS10585	COG0137	argininosuccinate synthase activity
GL183_RS10590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GL183_RS10615	COG1388	LysM domain
GL183_RS10615	COG1705	Flagellar rod assembly protein muramidase FlgJ
GL183_RS10620	COG1760	l-serine dehydratase
GL183_RS10625	COG1760	l-serine dehydratase
GL183_RS10630	COG0546	phosphoglycolate phosphatase activity
GL183_RS10655	COG1695	Transcriptional regulator
GL183_RS10685	COG1653	transport
GL183_RS10690	COG0395	ABC-type sugar transport system, permease component
GL183_RS10695	COG4209	transmembrane transport
GL183_RS10720	COG5002	protein histidine kinase activity
GL183_RS10745	COG0569	domain protein
GL183_RS10750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GL183_RS10780	COG1937	Protein conserved in bacteria
GL183_RS10785	COG2514	catechol 2,3-dioxygenase activity
GL183_RS10795	COG2222	sugar isomerase
GL183_RS10805	COG3716	PTS system mannose fructose sorbose family IID component
GL183_RS10810	COG3715	PTS system
GL183_RS10815	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GL183_RS10830	COG3064	Membrane
GL183_RS10830	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GL183_RS10830	COG3583	domain protein
GL183_RS10835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GL183_RS10850	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GL183_RS10855	COG0151	Belongs to the GarS family
GL183_RS10870	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GL183_RS10885	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GL183_RS10895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GL183_RS10900	COG2274	protein secretion by the type I secretion system
GL183_RS10910	COG1134	teichoic acid transport
GL183_RS10910	COG1388	LysM domain
GL183_RS10945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GL183_RS10960	COG0436	Aminotransferase
GL183_RS10965	COG2855	membrane
GL183_RS10975	COG1832	CoA-binding protein
GL183_RS10980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GL183_RS10980	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GL183_RS11005	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GL183_RS11025	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GL183_RS11035	COG0756	dUTP diphosphatase activity
GL183_RS11165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GL183_RS11170	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GL183_RS11190	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GL183_RS11195	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GL183_RS11205	COG0012	GTP binding