locus-tag	class	description
EZ481_RS00025	COG1012	belongs to the aldehyde dehydrogenase family
EZ481_RS00030	COG1523	belongs to the glycosyl hydrolase 13 family
EZ481_RS00035	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EZ481_RS00050	COG0488	(ABC) transporter
EZ481_RS00060	COG1307	EDD domain protein, DegV family
EZ481_RS00065	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EZ481_RS00070	COG0196	riboflavin kinase activity
EZ481_RS00110	COG0280	phosphate acetyltransferase
EZ481_RS00115	COG0564	pseudouridine synthase activity
EZ481_RS00125	COG2357	RelA SpoT domain protein
EZ481_RS00135	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EZ481_RS00140	COG1104	cysteine desulfurase activity
EZ481_RS00155	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EZ481_RS00160	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EZ481_RS00165	COG2003	Belongs to the UPF0758 family
EZ481_RS00170	COG0210	DNA helicase
EZ481_RS00185	COG0024	Methionine aminopeptidase
EZ481_RS00200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EZ481_RS00215	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EZ481_RS00230	COG0438	transferase activity, transferring glycosyl groups
EZ481_RS00235	COG0438	transferase activity, transferring glycosyl groups
EZ481_RS00240	COG2151	metal-sulfur cluster biosynthetic enzyme
EZ481_RS00245	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EZ481_RS00250	COG0358	DNA primase activity
EZ481_RS00270	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EZ481_RS00275	COG0772	Belongs to the SEDS family
EZ481_RS00370	COG3843	relaxase mobilization nuclease domain protein
EZ481_RS00395	COG0542	response to heat
EZ481_RS00400	COG1396	sequence-specific DNA binding
EZ481_RS00415	COG0366	Alpha amylase catalytic
EZ481_RS00420	COG1597	lipid kinase activity
EZ481_RS00470	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZ481_RS00475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZ481_RS00500	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EZ481_RS00510	COG0741	lytic transglycosylase activity
EZ481_RS00520	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EZ481_RS00535	COG2890	protein-(glutamine-N5) methyltransferase activity
EZ481_RS00550	COG1435	thymidine kinase activity
EZ481_RS00555	COG1942	4-Oxalocrotonate Tautomerase
EZ481_RS00560	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EZ481_RS00565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZ481_RS00570	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EZ481_RS00580	COG4708	membrane
EZ481_RS00595	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EZ481_RS00600	COG2195	Cleaves the N-terminal amino acid of tripeptides
EZ481_RS00635	COG3443	Belongs to the bacterial solute-binding protein 9 family
EZ481_RS00635	COG0803	Belongs to the bacterial solute-binding protein 9 family
EZ481_RS00640	COG0531	amino acid
EZ481_RS00645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EZ481_RS00650	COG0785	Cytochrome C biogenesis protein
EZ481_RS00670	COG0584	glycerophosphoryl diester phosphodiesterase
EZ481_RS00675	COG2176	DNA-directed DNA polymerase activity
EZ481_RS00685	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EZ481_RS00695	COG0494	nUDIX hydrolase
EZ481_RS00700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EZ481_RS00715	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EZ481_RS00745	COG4122	O-methyltransferase activity
EZ481_RS00760	COG0500	methyltransferase
EZ481_RS00760	COG3615	Tellurite resistance protein tehB
EZ481_RS00770	COG0557	exoribonuclease II activity
EZ481_RS00785	COG2814	Major facilitator Superfamily
EZ481_RS00790	COG0237	dephospho-CoA kinase activity
EZ481_RS00795	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EZ481_RS00805	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EZ481_RS00815	COG1293	RNA-binding protein homologous to eukaryotic snRNP
EZ481_RS00820	COG5263	repeat protein
EZ481_RS00820	COG4193	domain, Protein
EZ481_RS00825	COG0167	dihydroorotate dehydrogenase activity
EZ481_RS00830	COG0543	2 iron, 2 sulfur cluster binding
EZ481_RS00860	COG1131	(ABC) transporter
EZ481_RS00870	COG2333	competence protein COMEC
EZ481_RS00870	COG0658	competence protein
EZ481_RS00875	COG1596	polysaccharide export
EZ481_RS00875	COG1555	photosystem II stabilization
EZ481_RS00880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EZ481_RS00885	COG0686	Belongs to the AlaDH PNT family
EZ481_RS00890	COG0686	Belongs to the AlaDH PNT family
EZ481_RS00895	COG0686	Belongs to the AlaDH PNT family
EZ481_RS00915	COG1702	phosphate starvation-inducible protein PhoH
EZ481_RS00925	COG2996	Protein conserved in bacteria
EZ481_RS00930	COG0233	cytoplasmic translational termination
EZ481_RS00935	COG0528	UMP kinase activity
EZ481_RS00975	COG0470	DNA polymerase III
EZ481_RS00980	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EZ481_RS00985	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EZ481_RS00995	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EZ481_RS01000	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EZ481_RS01005	COG0564	pseudouridine synthase activity
EZ481_RS01010	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EZ481_RS01015	COG0583	DNA-binding transcription factor activity
EZ481_RS01035	COG0561	phosphatase activity
EZ481_RS01040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EZ481_RS01045	COG2957	Belongs to the agmatine deiminase family
EZ481_RS01060	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EZ481_RS01070	COG1982	Orn Lys Arg decarboxylase major
EZ481_RS01085	COG0577	efflux transmembrane transporter activity
EZ481_RS01090	COG1136	(ABC) transporter
EZ481_RS01110	COG2183	response to ionizing radiation
EZ481_RS01115	COG3955	Domain of unknown function (DUF1919)
EZ481_RS01130	COG0701	Predicted permease
EZ481_RS01135	COG3689	TIGRFAM TIGR03943 family protein
EZ481_RS01185	COG0469	pyruvate kinase activity
EZ481_RS01190	COG0205	6-phosphofructokinase activity
EZ481_RS01200	COG2936	dipeptidyl-peptidase activity
EZ481_RS01205	COG1438	arginine binding
EZ481_RS01215	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
EZ481_RS01245	COG0301	tRNA thio-modification
EZ481_RS01250	COG1104	cysteine desulfurase activity
EZ481_RS01270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EZ481_RS01270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EZ481_RS01270	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EZ481_RS01275	COG1105	Belongs to the carbohydrate kinase PfkB family
EZ481_RS01280	COG1349	DNA-binding transcription factor activity
EZ481_RS01295	COG0628	permease
EZ481_RS01300	COG1686	Belongs to the peptidase S11 family
EZ481_RS01305	COG0719	Fe-S assembly protein
EZ481_RS01315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EZ481_RS01320	COG0719	Fe-S assembly protein
EZ481_RS01335	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EZ481_RS01340	COG1956	GAF domain-containing protein
EZ481_RS01350	COG0539	negative regulation of cytoplasmic translation
EZ481_RS01385	COG4166	transmembrane transport
EZ481_RS01390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EZ481_RS01395	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EZ481_RS01400	COG0187	DNA topoisomerase II activity
EZ481_RS01420	COG4603	Belongs to the binding-protein-dependent transport system permease family
EZ481_RS01430	COG1744	ABC transporter substrate-binding protein PnrA-like
EZ481_RS01435	COG0295	cytidine deaminase activity
EZ481_RS01440	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EZ481_RS01445	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EZ481_RS01450	COG2813	Specifically methylates the guanine in position
EZ481_RS01505	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EZ481_RS01515	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EZ481_RS01525	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EZ481_RS01530	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EZ481_RS01535	COG1126	abc transporter atp-binding protein
EZ481_RS01540	COG0765	amino acid transport
EZ481_RS01545	COG4703	Protein of unknown function (DUF1797)
EZ481_RS01550	COG0542	response to heat
EZ481_RS01560	COG0494	nUDIX hydrolase
EZ481_RS01595	COG0187	DNA topoisomerase II activity
EZ481_RS01605	COG0693	protein deglycase activity
EZ481_RS01610	COG0772	Belongs to the SEDS family
EZ481_RS01630	COG5002	protein histidine kinase activity
EZ481_RS01665	COG1028	Short-chain dehydrogenase reductase Sdr
EZ481_RS01675	COG4989	oxidoreductase activity
EZ481_RS01695	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EZ481_RS01695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EZ481_RS01700	COG0577	efflux transmembrane transporter activity
EZ481_RS01705	COG1136	(ABC) transporter
EZ481_RS01710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZ481_RS01715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EZ481_RS01720	COG1268	BioY protein
EZ481_RS01730	COG4443	Transcriptional Coactivator p15 (PC4)
EZ481_RS01740	COG1328	CTP reductase activity
EZ481_RS01740	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EZ481_RS01770	COG1837	Belongs to the UPF0109 family
EZ481_RS01800	COG0488	(ABC) transporter
EZ481_RS01810	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EZ481_RS01815	COG4470	Protein conserved in bacteria
EZ481_RS01820	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EZ481_RS01830	COG0167	dihydroorotate dehydrogenase activity
EZ481_RS01845	COG0513	Belongs to the DEAD box helicase family
EZ481_RS01855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EZ481_RS01855	COG2190	(PTS) system
EZ481_RS01855	COG1263	PTS System
EZ481_RS01860	COG2177	Part of the ABC transporter FtsEX involved in
EZ481_RS01865	COG2884	Cell division ATP-binding protein ftsE
EZ481_RS01920	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EZ481_RS01925	COG2131	deaminase
EZ481_RS01935	COG1307	EDD domain protein, DegV family
EZ481_RS01940	COG2081	HI0933 family
EZ481_RS01955	COG0733	neurotransmitter:sodium symporter activity
EZ481_RS01960	COG1482	cell wall glycoprotein biosynthetic process
EZ481_RS01965	COG2723	6-phospho-beta-galactosidase activity
EZ481_RS01980	COG0028	Belongs to the TPP enzyme family
EZ481_RS01985	COG2217	Heavy metal translocating P-type atpase
EZ481_RS02005	COG0352	thiamine-phosphate diphosphorylase activity
EZ481_RS02010	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EZ481_RS02020	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EZ481_RS02030	COG4172	Belongs to the ABC transporter superfamily
EZ481_RS02045	COG0352	thiamine-phosphate diphosphorylase activity
EZ481_RS02050	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EZ481_RS02065	COG1304	FMN binding
EZ481_RS02080	COG1304	FMN binding
EZ481_RS02090	COG0765	amino acid transport
EZ481_RS02095	COG1126	abc transporter atp-binding protein
EZ481_RS02130	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EZ481_RS02170	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EZ481_RS02175	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EZ481_RS02180	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EZ481_RS02185	COG1136	(ABC) transporter
EZ481_RS02205	COG1217	gtp-binding protein TYPA
EZ481_RS02210	COG1187	pseudouridine synthase activity
EZ481_RS02220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EZ481_RS02235	COG0300	oxidoreductase activity
EZ481_RS02245	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
EZ481_RS02250	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EZ481_RS02255	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EZ481_RS02270	COG1940	carbohydrate kinase activity
EZ481_RS02285	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EZ481_RS02290	COG3064	Membrane
EZ481_RS02295	COG4475	Protein of unknown function (DUF436)
EZ481_RS02300	COG2972	Histidine kinase
EZ481_RS02305	COG2207	Transcriptional regulator
EZ481_RS02305	COG4753	response regulator
EZ481_RS02315	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EZ481_RS02315	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EZ481_RS02320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EZ481_RS02325	COG0785	Cytochrome C biogenesis protein
EZ481_RS02345	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EZ481_RS02375	COG3250	beta-galactosidase activity
EZ481_RS02385	COG3775	system Galactitol-specific IIC component
EZ481_RS02400	COG1404	Belongs to the peptidase S8 family
EZ481_RS02440	COG4555	ABC transporter
EZ481_RS02480	COG1363	Peptidase, m42
EZ481_RS02485	COG1114	Component of the transport system for branched-chain amino acids
EZ481_RS02500	COG1573	uracil-dna glycosylase
EZ481_RS02515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZ481_RS02525	COG0322	excinuclease ABC activity
EZ481_RS02555	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EZ481_RS02555	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EZ481_RS02565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZ481_RS02570	COG0765	amino acid transport
EZ481_RS02575	COG0765	amino acid transport
EZ481_RS02585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EZ481_RS02590	COG0191	fructose-bisphosphate aldolase activity
EZ481_RS02595	COG5002	protein histidine kinase activity
EZ481_RS02600	COG0745	RESPONSE REGULATOR receiver
EZ481_RS02610	COG1136	(ABC) transporter
EZ481_RS02615	COG0577	efflux transmembrane transporter activity
EZ481_RS02635	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
EZ481_RS02640	COG0215	cysteine-tRNA ligase activity
EZ481_RS02655	COG1045	serine acetyltransferase
EZ481_RS02660	COG1185	polyribonucleotide nucleotidyltransferase activity
EZ481_RS02675	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EZ481_RS02680	COG3620	sequence-specific DNA binding
EZ481_RS02695	COG0072	phenylalanine-tRNA ligase activity
EZ481_RS02695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EZ481_RS02700	COG0456	acetyltransferase
EZ481_RS02715	COG2190	(PTS) system
EZ481_RS02715	COG1263	PTS System
EZ481_RS02715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EZ481_RS02720	COG3711	transcriptional antiterminator
EZ481_RS02755	COG0525	valine-tRNA ligase activity
EZ481_RS02765	COG0519	Catalyzes the synthesis of GMP from XMP
EZ481_RS02810	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EZ481_RS02825	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EZ481_RS02830	COG0195	Participates in both transcription termination and antitermination
EZ481_RS02850	COG1266	CAAX protease self-immunity
EZ481_RS02890	COG3290	protein histidine kinase activity
EZ481_RS02915	COG1131	(ABC) transporter
EZ481_RS02920	COG0537	adenosine 5'-monophosphoramidase activity
EZ481_RS02930	COG0484	heat shock protein binding
EZ481_RS02945	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EZ481_RS02980	COG4974	Belongs to the 'phage' integrase family
EZ481_RS02990	COG0732	type I restriction modification DNA specificity domain
EZ481_RS03010	COG0174	glutamine synthetase
EZ481_RS03015	COG0789	Transcriptional regulator
EZ481_RS03025	COG0126	phosphoglycerate kinase activity
EZ481_RS03035	COG1283	sodium-dependent phosphate transmembrane transporter activity
EZ481_RS03040	COG0504	CTP synthase activity
EZ481_RS03050	COG1247	-acetyltransferase
EZ481_RS03060	COG0671	phosphoesterase, PA-phosphatase related
EZ481_RS03065	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
EZ481_RS03080	COG1122	ATPase activity
EZ481_RS03095	COG0569	domain protein
EZ481_RS03100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EZ481_RS03105	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EZ481_RS03105	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EZ481_RS03110	COG2723	6-phospho-beta-galactosidase activity
EZ481_RS03115	COG1447	Phosphotransferase system cellobiose-specific component IIA
EZ481_RS03125	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EZ481_RS03130	COG1846	Transcriptional regulator
EZ481_RS03130	COG1940	carbohydrate kinase activity
EZ481_RS03160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EZ481_RS03180	COG0765	amino acid transport
EZ481_RS03200	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EZ481_RS03220	COG0440	acetolactate synthase activity
EZ481_RS03225	COG0028	Belongs to the TPP enzyme family
EZ481_RS03230	COG1461	Dihydroxyacetone kinase
EZ481_RS03240	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EZ481_RS03245	COG1442	glycosyl transferase family 8
EZ481_RS03265	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EZ481_RS03310	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EZ481_RS03315	COG0439	Biotin carboxylase
EZ481_RS03330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EZ481_RS03335	COG1028	Short-chain dehydrogenase reductase Sdr
EZ481_RS03340	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EZ481_RS03350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EZ481_RS03360	COG1846	Transcriptional regulator
EZ481_RS03365	COG1024	Enoyl-CoA hydratase
EZ481_RS03385	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EZ481_RS03400	COG1115	amino acid carrier protein
EZ481_RS03405	COG1193	negative regulation of DNA recombination
EZ481_RS03425	COG0681	Belongs to the peptidase S26 family
EZ481_RS03430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EZ481_RS03435	COG0544	peptidyl-prolyl cis-trans isomerase activity
EZ481_RS03445	COG0246	Mannitol dehydrogenase
EZ481_RS03450	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EZ481_RS03455	COG3711	transcriptional antiterminator
EZ481_RS03460	COG2213	PTS system mannitol-specific
EZ481_RS03500	COG2197	response regulator
EZ481_RS03505	COG4585	Histidine kinase
EZ481_RS03540	COG0745	RESPONSE REGULATOR receiver
EZ481_RS03545	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EZ481_RS03555	COG0116	Belongs to the methyltransferase superfamily
EZ481_RS03580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EZ481_RS03585	COG0366	Alpha amylase catalytic
EZ481_RS03595	COG4166	transmembrane transport
EZ481_RS03605	COG4372	Transposase
EZ481_RS03615	COG1091	dTDP-4-dehydrorhamnose reductase activity
EZ481_RS03620	COG1088	dTDP-glucose 4,6-dehydratase activity
EZ481_RS03630	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EZ481_RS03635	COG0562	UDP-galactopyranose mutase
EZ481_RS03640	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EZ481_RS03670	COG4166	transmembrane transport
EZ481_RS03675	COG0366	Alpha amylase catalytic
EZ481_RS03680	COG4868	Belongs to the UPF0371 family
EZ481_RS03695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EZ481_RS03700	COG0768	penicillin binding
EZ481_RS03705	COG4839	cell division protein FtsL
EZ481_RS03730	COG1609	Transcriptional regulator
EZ481_RS03745	COG3716	PTS system mannose fructose sorbose family IID component
EZ481_RS03750	COG3715	PTS system
EZ481_RS03755	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EZ481_RS03760	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EZ481_RS03770	COG1028	Short-chain dehydrogenase reductase Sdr
EZ481_RS03805	COG5492	domain, Protein
EZ481_RS03810	COG0386	Belongs to the glutathione peroxidase family
EZ481_RS03830	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EZ481_RS03845	COG3711	transcriptional antiterminator
EZ481_RS03845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EZ481_RS03860	COG2723	6-phospho-beta-galactosidase activity
EZ481_RS03895	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EZ481_RS03895	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EZ481_RS03900	COG0302	gtp cyclohydrolase
EZ481_RS03905	COG0285	dihydrofolate synthase activity
EZ481_RS03910	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EZ481_RS03935	COG1064	alcohol dehydrogenase
EZ481_RS03945	COG3715	PTS system
EZ481_RS03950	COG3716	PTS system mannose fructose sorbose family IID component
EZ481_RS03955	COG3579	cysteine-type endopeptidase activity
EZ481_RS03965	COG1187	pseudouridine synthase activity
EZ481_RS03970	COG2261	transglycosylase associated protein
EZ481_RS03975	COG2309	aminopeptidase activity
EZ481_RS04020	COG1523	belongs to the glycosyl hydrolase 13 family
EZ481_RS04030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EZ481_RS04035	COG2723	6-phospho-beta-galactosidase activity
EZ481_RS04040	COG0442	prolyl-tRNA aminoacylation
EZ481_RS04045	COG0750	zinc metalloprotease
EZ481_RS04050	COG4589	Belongs to the CDS family
EZ481_RS04055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EZ481_RS04085	COG0495	leucyl-tRNA aminoacylation
EZ481_RS04100	COG1882	Formate acetyltransferase
EZ481_RS04105	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EZ481_RS04110	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EZ481_RS04115	COG1447	Phosphotransferase system cellobiose-specific component IIA
EZ481_RS04125	COG1349	DNA-binding transcription factor activity
EZ481_RS04130	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EZ481_RS04150	COG3842	ATPase activity
EZ481_RS04155	COG1178	ABC-type Fe3 transport system permease component
EZ481_RS04175	COG3830	Belongs to the UPF0237 family
EZ481_RS04185	COG0202	RNA polymerase activity
EZ481_RS04190	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EZ481_RS04200	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EZ481_RS04205	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EZ481_RS04215	COG0201	protein transport
EZ481_RS04230	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EZ481_RS04270	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EZ481_RS04295	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EZ481_RS04330	COG0602	queuosine metabolic process
EZ481_RS04360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EZ481_RS04370	COG0285	dihydrofolate synthase activity
EZ481_RS04395	COG1393	Belongs to the ArsC family
EZ481_RS04405	COG0006	proline dipeptidase activity
EZ481_RS04410	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EZ481_RS04435	COG2818	Glycosylase
EZ481_RS04455	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EZ481_RS04455	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EZ481_RS04495	COG1780	Probably involved in ribonucleotide reductase function
EZ481_RS04505	COG2207	Transcriptional regulator
EZ481_RS04505	COG4753	response regulator
EZ481_RS04510	COG2972	Histidine kinase
EZ481_RS04530	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EZ481_RS04535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EZ481_RS04540	COG1464	Belongs to the NlpA lipoprotein family
EZ481_RS04545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZ481_RS04575	COG1396	sequence-specific DNA binding
EZ481_RS04610	COG0438	transferase activity, transferring glycosyl groups
EZ481_RS04630	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EZ481_RS04640	COG1214	PFAM Peptidase M22, glycoprotease
EZ481_RS04675	COG0445	tRNA wobble uridine modification
EZ481_RS04680	COG0494	nUDIX hydrolase
EZ481_RS04685	COG0482	sulfurtransferase activity
EZ481_RS04795	COG0137	argininosuccinate synthase activity
EZ481_RS04800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZ481_RS04830	COG1760	l-serine dehydratase
EZ481_RS04835	COG1760	l-serine dehydratase
EZ481_RS04840	COG0546	phosphoglycolate phosphatase activity
EZ481_RS04865	COG1695	Transcriptional regulator
EZ481_RS04895	COG1653	transport
EZ481_RS04905	COG0395	ABC-type sugar transport system, permease component
EZ481_RS04910	COG4209	transmembrane transport
EZ481_RS04940	COG5002	protein histidine kinase activity
EZ481_RS04960	COG1215	transferase activity, transferring glycosyl groups
EZ481_RS04965	COG0569	domain protein
EZ481_RS04970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EZ481_RS05010	COG1937	Protein conserved in bacteria
EZ481_RS05015	COG2514	catechol 2,3-dioxygenase activity
EZ481_RS05025	COG2222	sugar isomerase
EZ481_RS05035	COG3716	PTS system mannose fructose sorbose family IID component
EZ481_RS05040	COG3715	PTS system
EZ481_RS05045	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EZ481_RS05060	COG3064	Membrane
EZ481_RS05060	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EZ481_RS05060	COG3583	domain protein
EZ481_RS05065	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EZ481_RS05080	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EZ481_RS05095	COG0151	Belongs to the GarS family
EZ481_RS05110	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EZ481_RS05115	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EZ481_RS05120	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EZ481_RS05125	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EZ481_RS05135	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EZ481_RS05140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZ481_RS05145	COG2274	protein secretion by the type I secretion system
EZ481_RS05170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EZ481_RS05180	COG1381	Involved in DNA repair and RecF pathway recombination
EZ481_RS05185	COG0436	Aminotransferase
EZ481_RS05190	COG2855	membrane
EZ481_RS05195	COG1832	CoA-binding protein
EZ481_RS05200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EZ481_RS05200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EZ481_RS05225	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EZ481_RS05240	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EZ481_RS05250	COG0756	dUTP diphosphatase activity
EZ481_RS05320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EZ481_RS05325	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EZ481_RS05330	COG0037	tRNA processing
EZ481_RS05345	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EZ481_RS05350	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EZ481_RS05355	COG0193	aminoacyl-tRNA hydrolase activity
EZ481_RS05360	COG0012	GTP binding
EZ481_RS05370	COG0592	DNA-directed DNA polymerase activity
EZ481_RS05380	COG1475	DNA binding
EZ481_RS05385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EZ481_RS05445	COG1511	domain protein
EZ481_RS05455	COG0488	(ABC) transporter
EZ481_RS05460	COG0180	Tryptophanyl-tRNA synthetase
EZ481_RS05475	COG2501	S4 domain
EZ481_RS05480	COG0612	Peptidase, M16
EZ481_RS05485	COG0612	Peptidase, M16
EZ481_RS05495	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EZ481_RS05500	COG1122	ATPase activity
EZ481_RS05505	COG1122	ATPase activity
EZ481_RS05510	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EZ481_RS05515	COG1792	Involved in formation and maintenance of cell shape
EZ481_RS05525	COG3942	CHAP domain
EZ481_RS05530	COG0052	Belongs to the universal ribosomal protein uS2 family
EZ481_RS05565	COG1739	Uncharacterized protein family UPF0029
EZ481_RS05570	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EZ481_RS05575	COG1040	competence protein
EZ481_RS05595	COG0305	Participates in initiation and elongation during chromosome replication
EZ481_RS05615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZ481_RS05625	COG1116	anion transmembrane transporter activity
EZ481_RS05630	COG4463	regulation of RNA biosynthetic process
EZ481_RS05635	COG0542	response to heat
EZ481_RS05655	COG0745	RESPONSE REGULATOR receiver
EZ481_RS05660	COG5002	protein histidine kinase activity
EZ481_RS05665	COG1755	Isoprenylcysteine carboxyl methyltransferase
EZ481_RS05675	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EZ481_RS05695	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EZ481_RS05700	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EZ481_RS05725	COG3344	reverse transcriptase
EZ481_RS05730	COG2211	Major facilitator Superfamily
EZ481_RS05745	COG1696	Membrane protein involved in D-alanine export
EZ481_RS05755	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EZ481_RS05765	COG1121	(ABC) transporter
EZ481_RS05770	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EZ481_RS05775	COG3443	Belongs to the bacterial solute-binding protein 9 family
EZ481_RS05775	COG0803	Belongs to the bacterial solute-binding protein 9 family
EZ481_RS05785	COG1070	Carbohydrate kinase
EZ481_RS05805	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EZ481_RS05815	COG3716	PTS system mannose fructose sorbose family IID component
EZ481_RS05830	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
EZ481_RS05835	COG1454	alcohol dehydrogenase
EZ481_RS05865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EZ481_RS05870	COG1288	antiporter activity
EZ481_RS05900	COG3537	Alpha-1,2-mannosidase
EZ481_RS05910	COG0383	alpha-mannosidase activity
EZ481_RS05940	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EZ481_RS05960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EZ481_RS05975	COG3959	Transketolase, thiamine diphosphate binding domain
EZ481_RS05980	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EZ481_RS05990	COG2151	metal-sulfur cluster biosynthetic enzyme
EZ481_RS06025	COG1476	TRANSCRIPTIONal
EZ481_RS06055	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EZ481_RS06060	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EZ481_RS06070	COG1609	Transcriptional regulator
EZ481_RS06075	COG5521	maltodextrose utilization protein MalA
EZ481_RS06085	COG3833	ABC-type maltose transport systems, permease component
EZ481_RS06090	COG1175	transmembrane transport
EZ481_RS06095	COG2182	Extracellular solute-binding protein
EZ481_RS06100	COG1640	4-alpha-glucanotransferase
EZ481_RS06105	COG0058	SHG alpha-glucan phosphorylase activity
EZ481_RS06125	COG2226	methyltransferase
EZ481_RS06135	COG2217	Heavy metal translocating P-type atpase
EZ481_RS06150	COG0697	spore germination
EZ481_RS06165	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EZ481_RS06175	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EZ481_RS06195	COG0704	Plays a role in the regulation of phosphate uptake
EZ481_RS06210	COG0573	inorganic phosphate transmembrane transporter activity
EZ481_RS06215	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EZ481_RS06220	COG5002	protein histidine kinase activity
EZ481_RS06225	COG0745	RESPONSE REGULATOR receiver
EZ481_RS06245	COG1438	arginine binding
EZ481_RS06255	COG1132	(ABC) transporter
EZ481_RS06265	COG1132	(ABC) transporter
EZ481_RS06270	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EZ481_RS06285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EZ481_RS06385	COG0534	Mate efflux family protein
EZ481_RS06435	COG1063	alcohol dehydrogenase
EZ481_RS06445	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EZ481_RS06450	COG1459	type II secretion system
EZ481_RS06455	COG4537	Required for transformation and DNA binding
EZ481_RS06490	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EZ481_RS06500	COG0706	membrane insertase activity
EZ481_RS06505	COG1847	R3H domain protein
EZ481_RS06515	COG3037	sugar-specific permease SgaT UlaA
EZ481_RS06525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EZ481_RS06535	COG3623	hexulose-6-phosphate isomerase
EZ481_RS06555	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EZ481_RS06565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EZ481_RS06575	COG1454	alcohol dehydrogenase
EZ481_RS06575	COG1012	belongs to the aldehyde dehydrogenase family
EZ481_RS06580	COG1447	Phosphotransferase system cellobiose-specific component IIA
EZ481_RS06590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EZ481_RS06595	COG2723	6-phospho-beta-galactosidase activity
EZ481_RS06600	COG2188	Transcriptional regulator
EZ481_RS06605	COG1129	ABC transporter
EZ481_RS06620	COG0157	Belongs to the NadC ModD family
EZ481_RS06630	COG0577	efflux transmembrane transporter activity
EZ481_RS06640	COG0564	pseudouridine synthase activity
EZ481_RS06645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EZ481_RS06650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EZ481_RS06750	COG1131	(ABC) transporter
EZ481_RS06755	COG0842	Transport permease protein
EZ481_RS06760	COG4585	Histidine kinase
EZ481_RS06765	COG2197	response regulator
EZ481_RS06770	COG1609	Transcriptional regulator
EZ481_RS06780	COG0252	asparaginase activity
EZ481_RS06785	COG0561	phosphatase activity
EZ481_RS06800	COG0436	Aminotransferase
EZ481_RS06820	COG0084	hydrolase, TatD family'
EZ481_RS06825	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EZ481_RS06850	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EZ481_RS06855	COG1162	GTPase activity
EZ481_RS06865	COG1564	THIamine pyrophosphokinase
EZ481_RS06885	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EZ481_RS06895	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EZ481_RS06900	COG0706	membrane insertase activity
EZ481_RS06905	COG1254	Belongs to the acylphosphatase family
EZ481_RS06910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EZ481_RS06925	COG2502	aspartate--ammonia ligase
EZ481_RS06930	COG0742	ribosomal rna small subunit methyltransferase
EZ481_RS06935	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EZ481_RS06940	COG3480	Lon protease (S16) C-terminal proteolytic domain
EZ481_RS06950	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EZ481_RS06965	COG1253	flavin adenine dinucleotide binding
EZ481_RS06990	COG1136	(ABC) transporter
EZ481_RS07055	COG0802	atpase or kinase
EZ481_RS07065	COG1316	TRANSCRIPTIONal
EZ481_RS07070	COG1058	Belongs to the CinA family
EZ481_RS07070	COG1546	Belongs to the CinA family
EZ481_RS07090	COG5632	N-Acetylmuramoyl-L-alanine amidase
EZ481_RS07090	COG5263	repeat protein
EZ481_RS07185	COG1132	(ABC) transporter
EZ481_RS07220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EZ481_RS07225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EZ481_RS07240	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EZ481_RS07270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EZ481_RS07390	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EZ481_RS07390	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EZ481_RS07395	COG2207	Transcriptional regulator
EZ481_RS07400	COG3345	alpha-galactosidase
EZ481_RS07405	COG1653	transport
EZ481_RS07410	COG1175	transmembrane transport
EZ481_RS07415	COG0395	ABC-type sugar transport system, permease component
EZ481_RS07420	COG0366	Alpha amylase catalytic
EZ481_RS07435	COG4166	transmembrane transport
EZ481_RS07440	COG0601	transmembrane transport
EZ481_RS07445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EZ481_RS07450	COG0444	Belongs to the ABC transporter superfamily
EZ481_RS07455	COG4608	Belongs to the ABC transporter superfamily
EZ481_RS07465	COG2188	Transcriptional regulator
EZ481_RS07480	COG0366	Alpha amylase catalytic
EZ481_RS07495	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EZ481_RS07505	COG0517	IMP dehydrogenase activity
EZ481_RS07525	COG1187	pseudouridine synthase activity
EZ481_RS07535	COG4607	ABC-type enterochelin transport system periplasmic component
EZ481_RS07540	COG4604	ABC transporter, ATP-binding protein
EZ481_RS07545	COG4605	iron ion homeostasis
EZ481_RS07550	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZ481_RS07565	COG1363	Peptidase, m42
EZ481_RS07590	COG1174	glycine betaine transport
EZ481_RS07605	COG3201	nicotinamide mononucleotide transporter
EZ481_RS07615	COG1230	cation diffusion facilitator family transporter
EZ481_RS07620	COG0789	Transcriptional regulator
EZ481_RS07625	COG1063	alcohol dehydrogenase
EZ481_RS07630	COG1609	Transcriptional regulator
EZ481_RS07635	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EZ481_RS07640	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
EZ481_RS07660	COG2233	PERMEase
EZ481_RS07665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EZ481_RS07680	COG0708	Exodeoxyribonuclease III
EZ481_RS07705	COG1132	(ABC) transporter
EZ481_RS07715	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EZ481_RS07720	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EZ481_RS07730	COG5434	Belongs to the glycosyl hydrolase 28 family
EZ481_RS07745	COG0704	Plays a role in the regulation of phosphate uptake
EZ481_RS07750	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
EZ481_RS07755	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EZ481_RS07775	COG1178	ABC-type Fe3 transport system permease component
EZ481_RS07780	COG1285	pathogenesis
EZ481_RS07800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EZ481_RS07805	COG0512	Glutamine amidotransferase of anthranilate synthase
EZ481_RS07820	COG0135	phosphoribosylanthranilate isomerase activity
EZ481_RS07825	COG0133	tryptophan synthase activity
EZ481_RS07830	COG0159	tryptophan synthase activity
EZ481_RS07865	COG3237	CsbD-like
EZ481_RS07890	COG3711	transcriptional antiterminator
EZ481_RS07895	COG1609	Transcriptional regulator
EZ481_RS07905	COG1175	transmembrane transport
EZ481_RS07910	COG0395	ABC-type sugar transport system, permease component
EZ481_RS07925	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EZ481_RS07970	COG1051	belongs to the nudix hydrolase family
EZ481_RS07975	COG2264	protein methyltransferase activity
EZ481_RS07980	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EZ481_RS07985	COG1164	Oligoendopeptidase f
EZ481_RS07995	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EZ481_RS08010	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EZ481_RS08015	COG3118	belongs to the thioredoxin family
EZ481_RS08035	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EZ481_RS08045	COG0668	transmembrane transport
EZ481_RS08060	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EZ481_RS08065	COG1534	Rna-binding protein
EZ481_RS08070	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EZ481_RS08075	COG1713	HD superfamily hydrolase involved in NAD metabolism
EZ481_RS08085	COG0799	negative regulation of ribosome biogenesis
EZ481_RS08090	COG2226	methyltransferase
EZ481_RS08095	COG1323	Belongs to the UPF0348 family
EZ481_RS08105	COG4115	mRNA cleavage
EZ481_RS08115	COG0194	GDP metabolic process
EZ481_RS08125	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EZ481_RS08135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EZ481_RS08135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EZ481_RS08140	COG0631	protein serine/threonine phosphatase activity
EZ481_RS08170	COG3425	synthase
EZ481_RS08180	COG1609	Transcriptional regulator
EZ481_RS08185	COG1621	beta-fructofuranosidase activity
EZ481_RS08195	COG2190	(PTS) system
EZ481_RS08195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EZ481_RS08195	COG1263	PTS System
EZ481_RS08200	COG1940	carbohydrate kinase activity
EZ481_RS08220	COG4152	abc transporter atp-binding protein
EZ481_RS08225	COG1668	transmembrane transport
EZ481_RS08235	COG1131	(ABC) transporter
EZ481_RS08240	COG1725	Transcriptional regulator
EZ481_RS08255	COG1484	DNA-dependent DNA replication
EZ481_RS08300	COG1131	(ABC) transporter
EZ481_RS08310	COG0653	protein targeting
EZ481_RS08315	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EZ481_RS08320	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EZ481_RS08335	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EZ481_RS08345	COG3458	cephalosporin-C deacetylase activity
EZ481_RS08365	COG1653	transport
EZ481_RS08370	COG1175	transmembrane transport
EZ481_RS08380	COG4409	exo-alpha-(2->6)-sialidase activity
EZ481_RS08385	COG0673	inositol 2-dehydrogenase activity
EZ481_RS08395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EZ481_RS08395	COG2190	(PTS) system
EZ481_RS08395	COG1263	PTS System
EZ481_RS08405	COG1175	transmembrane transport
EZ481_RS08410	COG0395	ABC-type sugar transport system, permease component
EZ481_RS08415	COG2731	YhcH YjgK YiaL family protein
EZ481_RS08450	COG0768	penicillin binding
EZ481_RS08460	COG1181	Belongs to the D-alanine--D-alanine ligase family
EZ481_RS08465	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EZ481_RS08470	COG1051	belongs to the nudix hydrolase family
EZ481_RS08490	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EZ481_RS08510	COG3599	regulation of cell shape
EZ481_RS08520	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EZ481_RS08550	COG1136	(ABC) transporter
EZ481_RS08550	COG0577	efflux transmembrane transporter activity
EZ481_RS08560	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EZ481_RS08565	COG0803	Belongs to the bacterial solute-binding protein 9 family
EZ481_RS08640	COG1959	2 iron, 2 sulfur cluster binding
EZ481_RS08655	COG0745	RESPONSE REGULATOR receiver
EZ481_RS08660	COG5002	protein histidine kinase activity
EZ481_RS08665	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EZ481_RS08695	COG2910	NAD(P)H-binding
EZ481_RS08710	COG0204	Acyl-transferase
EZ481_RS08715	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EZ481_RS08720	COG2384	SAM-dependent methyltransferase
EZ481_RS08725	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EZ481_RS08730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EZ481_RS08735	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EZ481_RS08740	COG0463	Glycosyl transferase, family 2
EZ481_RS08760	COG2824	Alkylphosphonate utilization operon protein PhnA
EZ481_RS08785	COG0351	phosphomethylpyrimidine kinase
EZ481_RS08790	COG4720	Psort location CytoplasmicMembrane, score
EZ481_RS08805	COG0006	proline dipeptidase activity
EZ481_RS08810	COG3442	glutamine amidotransferase
EZ481_RS08815	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EZ481_RS08820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EZ481_RS08825	COG2223	nitrite transmembrane transporter activity
EZ481_RS08830	COG0513	Belongs to the DEAD box helicase family
EZ481_RS08840	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EZ481_RS08845	COG1335	isochorismatase
EZ481_RS08855	COG3842	ATPase activity
EZ481_RS08860	COG2226	methyltransferase
EZ481_RS08875	COG3935	DnaD domain protein
EZ481_RS08885	COG5263	repeat protein
EZ481_RS08885	COG4193	domain, Protein
EZ481_RS08895	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EZ481_RS08915	COG0251	oxidation-reduction process
EZ481_RS08920	COG1660	Displays ATPase and GTPase activities
EZ481_RS08925	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EZ481_RS08930	COG1481	regulation of sporulation
EZ481_RS08935	COG0492	ferredoxin-NADP+ reductase activity
EZ481_RS08945	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EZ481_RS08955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EZ481_RS08965	COG1307	EDD domain protein, DegV family
EZ481_RS08975	COG0617	tRNA 3'-terminal CCA addition
EZ481_RS08980	COG0488	(ABC) transporter
EZ481_RS08985	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EZ481_RS08995	COG0625	glutathione transferase activity
EZ481_RS09000	COG0242	peptide deformylase activity
EZ481_RS09025	COG3711	transcriptional antiterminator
EZ481_RS09050	COG0436	Aminotransferase
EZ481_RS09060	COG0017	Asparaginyl-tRNA synthetase
EZ481_RS09070	COG0629	single-stranded DNA binding
EZ481_RS09075	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EZ481_RS09085	COG1098	S1 RNA binding domain
EZ481_RS09090	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EZ481_RS09095	COG2827	Endonuclease containing a URI domain
EZ481_RS09120	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EZ481_RS09125	COG2244	polysaccharide biosynthetic process
EZ481_RS09130	COG4166	transmembrane transport
EZ481_RS09140	COG1132	(ABC) transporter
EZ481_RS09150	COG0626	cystathionine gamma-synthase activity
EZ481_RS09155	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EZ481_RS09160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EZ481_RS09185	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EZ481_RS09235	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EZ481_RS09250	COG2706	6-phosphogluconolactonase activity
EZ481_RS09255	COG0628	permease
EZ481_RS09270	COG1126	abc transporter atp-binding protein
EZ481_RS09275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZ481_RS09290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EZ481_RS09325	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EZ481_RS09375	COG0726	polysaccharide deacetylase
EZ481_RS09380	COG0656	L-ascorbic acid biosynthetic process
EZ481_RS09395	COG0751	glycine-tRNA ligase activity
EZ481_RS09405	COG0431	NADPH-dependent FMN reductase
EZ481_RS09405	COG3976	FMN-binding domain protein
EZ481_RS09405	COG1053	succinate dehydrogenase
EZ481_RS09430	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EZ481_RS09435	COG1272	protein, Hemolysin III
EZ481_RS09450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EZ481_RS09455	COG1393	Belongs to the ArsC family
EZ481_RS09465	COG1126	abc transporter atp-binding protein
EZ481_RS09475	COG0492	ferredoxin-NADP+ reductase activity
EZ481_RS09510	COG0561	phosphatase activity
EZ481_RS09525	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EZ481_RS09530	COG0697	spore germination
EZ481_RS09535	COG2188	Transcriptional regulator
EZ481_RS09580	COG1129	ABC transporter
EZ481_RS09595	COG1132	(ABC) transporter
EZ481_RS09625	COG0826	peptidase U32
EZ481_RS09640	COG1131	(ABC) transporter
EZ481_RS09660	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EZ481_RS09670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EZ481_RS09680	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EZ481_RS09695	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EZ481_RS09715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EZ481_RS09725	COG0647	UMP catabolic process
EZ481_RS09735	COG1393	Belongs to the ArsC family
EZ481_RS09745	COG0483	inositol monophosphate 1-phosphatase activity
EZ481_RS09750	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EZ481_RS09750	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
EZ481_RS09755	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EZ481_RS09760	COG0573	inorganic phosphate transmembrane transporter activity
EZ481_RS09765	COG0581	inorganic phosphate transmembrane transporter activity
EZ481_RS09770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EZ481_RS09775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EZ481_RS09780	COG0704	Plays a role in the regulation of phosphate uptake
EZ481_RS09785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZ481_RS09790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EZ481_RS09795	COG3527	Alpha-acetolactate decarboxylase
EZ481_RS09810	COG3842	ATPase activity
EZ481_RS09840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EZ481_RS09890	COG0287	Prephenate dehydrogenase
EZ481_RS09900	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EZ481_RS09905	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EZ481_RS09910	COG0077	Prephenate dehydratase
EZ481_RS09920	COG3475	LICD family
EZ481_RS09930	COG1215	transferase activity, transferring glycosyl groups
EZ481_RS09945	COG4862	establishment of competence for transformation
EZ481_RS09965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EZ481_RS09965	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EZ481_RS10035	COG0515	serine threonine protein kinase
EZ481_RS10040	COG1770	oligopeptidase
EZ481_RS10050	COG0577	efflux transmembrane transporter activity
EZ481_RS10050	COG1136	(ABC) transporter
EZ481_RS10085	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
EZ481_RS10100	COG0601	transmembrane transport
EZ481_RS10105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EZ481_RS10120	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EZ481_RS10125	COG0295	cytidine deaminase activity
EZ481_RS10165	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EZ481_RS10190	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EZ481_RS10195	COG0716	FMN binding
EZ481_RS10200	COG1605	Chorismate mutase
EZ481_RS10200	COG0077	Prephenate dehydratase
EZ481_RS10205	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EZ481_RS10210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EZ481_RS10215	COG0335	large ribosomal subunit rRNA binding
EZ481_RS10230	COG1078	dGTPase activity
EZ481_RS10245	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EZ481_RS10260	COG1704	LemA family
EZ481_RS10270	COG0488	(ABC) transporter
EZ481_RS10285	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EZ481_RS10295	COG0540	Belongs to the ATCase OTCase family
EZ481_RS10300	COG0505	Belongs to the CarA family
EZ481_RS10305	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EZ481_RS10310	COG3475	LICD family
EZ481_RS10315	COG3475	LICD family
EZ481_RS10325	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EZ481_RS10330	COG1063	alcohol dehydrogenase
EZ481_RS10345	COG4750	Nucleotidyl transferase
EZ481_RS10350	COG0758	DNA mediated transformation
EZ481_RS10365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EZ481_RS10370	COG2832	Protein of unknown function (DUF454)
EZ481_RS10375	COG3142	Participates in the control of copper homeostasis
EZ481_RS10405	COG0066	3-isopropylmalate dehydratase activity
EZ481_RS10415	COG1401	restriction endodeoxyribonuclease activity
EZ481_RS10440	COG1196	nuclear chromosome segregation
EZ481_RS10445	COG0561	phosphatase activity
EZ481_RS10450	COG0561	phosphatase activity
EZ481_RS10455	COG0552	protein localization to endoplasmic reticulum
EZ481_RS10460	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EZ481_RS10465	COG1126	abc transporter atp-binding protein
EZ481_RS10480	COG0556	nucleotide-excision repair
EZ481_RS10500	COG1827	regulation of RNA biosynthetic process
EZ481_RS10510	COG4684	Psort location CytoplasmicMembrane, score
EZ481_RS10515	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EZ481_RS10535	COG1194	a g-specific adenine glycosylase
EZ481_RS10540	COG0745	RESPONSE REGULATOR receiver
EZ481_RS10545	COG5002	protein histidine kinase activity
EZ481_RS10550	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EZ481_RS10580	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EZ481_RS10585	COG3764	Sortase (surface protein transpeptidase)
EZ481_RS10610	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EZ481_RS10630	COG1570	exodeoxyribonuclease VII activity
EZ481_RS10645	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EZ481_RS10650	COG1438	arginine binding
EZ481_RS10655	COG0497	DNA recombination
EZ481_RS10660	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EZ481_RS10710	COG3684	Belongs to the aldolase LacD family
EZ481_RS10730	COG2723	6-phospho-beta-galactosidase activity
EZ481_RS10745	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EZ481_RS10755	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EZ481_RS10760	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EZ481_RS10785	COG1011	Hydrolase
EZ481_RS10800	COG1051	belongs to the nudix hydrolase family
EZ481_RS10805	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EZ481_RS10820	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EZ481_RS10825	COG0022	dehydrogenase e1 component
EZ481_RS10830	COG0508	dehydrogenase complex catalyzes the overall conversion of
EZ481_RS10835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EZ481_RS10840	COG0095	Lipoate-protein ligase
EZ481_RS10855	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EZ481_RS10860	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EZ481_RS10875	COG3583	domain protein
EZ481_RS10875	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EZ481_RS10890	COG1074	ATP-dependent DNA helicase activity
EZ481_RS10915	COG0582	viral genome integration into host DNA
EZ481_RS10940	COG0297	glycogen (starch) synthase activity
EZ481_RS10945	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans