locus-tag	class	description
HKM25_RS00010	COG0592	DNA-directed DNA polymerase activity
HKM25_RS00105	COG4974	Belongs to the 'phage' integrase family
HKM25_RS00110	COG0012	GTP binding
HKM25_RS00120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HKM25_RS00125	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HKM25_RS00150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HKM25_RS00220	COG0756	dUTP diphosphatase activity
HKM25_RS00230	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HKM25_RS00245	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HKM25_RS00265	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HKM25_RS00265	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HKM25_RS00270	COG1832	CoA-binding protein
HKM25_RS00275	COG2855	membrane
HKM25_RS00280	COG0436	Aminotransferase
HKM25_RS00295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKM25_RS00330	COG1134	teichoic acid transport
HKM25_RS00330	COG1388	LysM domain
HKM25_RS00340	COG2274	protein secretion by the type I secretion system
HKM25_RS00345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKM25_RS00355	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HKM25_RS00370	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HKM25_RS00385	COG0151	Belongs to the GarS family
HKM25_RS00390	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HKM25_RS00405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HKM25_RS00410	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HKM25_RS00410	COG3583	domain protein
HKM25_RS00410	COG3064	Membrane
HKM25_RS00425	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKM25_RS00430	COG3715	PTS system
HKM25_RS00435	COG3716	PTS system mannose fructose sorbose family IID component
HKM25_RS00445	COG2222	sugar isomerase
HKM25_RS00455	COG2514	catechol 2,3-dioxygenase activity
HKM25_RS00460	COG1937	Protein conserved in bacteria
HKM25_RS00490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HKM25_RS00495	COG0569	domain protein
HKM25_RS00505	COG1215	transferase activity, transferring glycosyl groups
HKM25_RS00525	COG5002	protein histidine kinase activity
HKM25_RS00555	COG4209	transmembrane transport
HKM25_RS00560	COG0395	ABC-type sugar transport system, permease component
HKM25_RS00595	COG1695	Transcriptional regulator
HKM25_RS00620	COG0546	phosphoglycolate phosphatase activity
HKM25_RS00625	COG1760	l-serine dehydratase
HKM25_RS00630	COG1760	l-serine dehydratase
HKM25_RS00660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKM25_RS00665	COG0137	argininosuccinate synthase activity
HKM25_RS00740	COG0494	nUDIX hydrolase
HKM25_RS00745	COG0445	tRNA wobble uridine modification
HKM25_RS00775	COG1214	PFAM Peptidase M22, glycoprotease
HKM25_RS00835	COG1396	sequence-specific DNA binding
HKM25_RS00870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKM25_RS00875	COG1464	Belongs to the NlpA lipoprotein family
HKM25_RS00880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HKM25_RS00885	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HKM25_RS00905	COG2972	Histidine kinase
HKM25_RS00910	COG4753	response regulator
HKM25_RS00910	COG2207	Transcriptional regulator
HKM25_RS00920	COG1780	Probably involved in ribonucleotide reductase function
HKM25_RS00950	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HKM25_RS00950	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HKM25_RS00970	COG2818	Glycosylase
HKM25_RS00995	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HKM25_RS01000	COG0006	proline dipeptidase activity
HKM25_RS01005	COG1393	Belongs to the ArsC family
HKM25_RS01030	COG0285	dihydrofolate synthase activity
HKM25_RS01040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HKM25_RS01070	COG0602	queuosine metabolic process
HKM25_RS01105	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HKM25_RS01130	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HKM25_RS01170	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HKM25_RS01185	COG0201	protein transport
HKM25_RS01195	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HKM25_RS01200	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HKM25_RS01210	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HKM25_RS01215	COG0202	RNA polymerase activity
HKM25_RS01225	COG3830	Belongs to the UPF0237 family
HKM25_RS01260	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HKM25_RS01265	COG1349	DNA-binding transcription factor activity
HKM25_RS01275	COG1447	Phosphotransferase system cellobiose-specific component IIA
HKM25_RS01280	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HKM25_RS01285	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HKM25_RS01290	COG1882	Formate acetyltransferase
HKM25_RS01335	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HKM25_RS01340	COG4589	Belongs to the CDS family
HKM25_RS01345	COG0750	zinc metalloprotease
HKM25_RS01355	COG2723	6-phospho-beta-galactosidase activity
HKM25_RS01360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HKM25_RS01375	COG1523	belongs to the glycosyl hydrolase 13 family
HKM25_RS01395	COG2176	DNA-directed DNA polymerase activity
HKM25_RS01415	COG2309	aminopeptidase activity
HKM25_RS01420	COG2261	transglycosylase associated protein
HKM25_RS01425	COG1187	pseudouridine synthase activity
HKM25_RS01430	COG3579	cysteine-type endopeptidase activity
HKM25_RS01435	COG3716	PTS system mannose fructose sorbose family IID component
HKM25_RS01440	COG3715	PTS system
HKM25_RS01450	COG1064	alcohol dehydrogenase
HKM25_RS01455	COG0561	phosphatase activity
HKM25_RS01460	COG2252	PERMEase
HKM25_RS01470	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HKM25_RS01475	COG0285	dihydrofolate synthase activity
HKM25_RS01485	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HKM25_RS01485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HKM25_RS01495	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HKM25_RS01505	COG0582	viral genome integration into host DNA
HKM25_RS01550	COG3118	belongs to the thioredoxin family
HKM25_RS01555	COG0492	ferredoxin-NADP+ reductase activity
HKM25_RS01565	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HKM25_RS01610	COG2723	6-phospho-beta-galactosidase activity
HKM25_RS01625	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKM25_RS01625	COG3711	transcriptional antiterminator
HKM25_RS01640	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HKM25_RS01655	COG0386	Belongs to the glutathione peroxidase family
HKM25_RS01660	COG5492	domain, Protein
HKM25_RS01685	COG1028	Short-chain dehydrogenase reductase Sdr
HKM25_RS01695	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HKM25_RS01700	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKM25_RS01705	COG3715	PTS system
HKM25_RS01710	COG3716	PTS system mannose fructose sorbose family IID component
HKM25_RS01725	COG1609	Transcriptional regulator
HKM25_RS01755	COG4839	cell division protein FtsL
HKM25_RS01760	COG0768	penicillin binding
HKM25_RS01790	COG0366	Alpha amylase catalytic
HKM25_RS01795	COG4166	transmembrane transport
HKM25_RS01810	COG4464	protein tyrosine phosphatase activity
HKM25_RS01815	COG3944	biosynthesis protein
HKM25_RS01820	COG0489	protein tyrosine kinase activity
HKM25_RS01830	COG1442	glycosyl transferase family 8
HKM25_RS01835	COG3475	LICD family
HKM25_RS01845	COG0463	Glycosyl transferase, family 2
HKM25_RS01860	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HKM25_RS01870	COG1088	dTDP-glucose 4,6-dehydratase activity
HKM25_RS01875	COG1091	dTDP-4-dehydrorhamnose reductase activity
HKM25_RS01895	COG4166	transmembrane transport
HKM25_RS01900	COG0366	Alpha amylase catalytic
HKM25_RS01905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HKM25_RS01930	COG0116	Belongs to the methyltransferase superfamily
HKM25_RS01940	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HKM25_RS01945	COG0745	RESPONSE REGULATOR receiver
HKM25_RS02005	COG4585	Histidine kinase
HKM25_RS02010	COG2197	response regulator
HKM25_RS02035	COG0582	viral genome integration into host DNA
HKM25_RS02040	COG0544	peptidyl-prolyl cis-trans isomerase activity
HKM25_RS02045	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HKM25_RS02050	COG0681	Belongs to the peptidase S26 family
HKM25_RS02075	COG1115	amino acid carrier protein
HKM25_RS02100	COG0527	aspartate kinase activity
HKM25_RS02105	COG1024	Enoyl-CoA hydratase
HKM25_RS02110	COG1846	Transcriptional regulator
HKM25_RS02120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKM25_RS02130	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HKM25_RS02135	COG1028	Short-chain dehydrogenase reductase Sdr
HKM25_RS02140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HKM25_RS02155	COG0439	Biotin carboxylase
HKM25_RS02160	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HKM25_RS02195	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HKM25_RS02210	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HKM25_RS02220	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HKM25_RS02230	COG1461	Dihydroxyacetone kinase
HKM25_RS02240	COG0028	Belongs to the TPP enzyme family
HKM25_RS02245	COG0440	acetolactate synthase activity
HKM25_RS02265	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HKM25_RS02280	COG0765	amino acid transport
HKM25_RS02300	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HKM25_RS02305	COG1882	Formate acetyltransferase
HKM25_RS02330	COG1940	carbohydrate kinase activity
HKM25_RS02330	COG1846	Transcriptional regulator
HKM25_RS02335	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HKM25_RS02345	COG1447	Phosphotransferase system cellobiose-specific component IIA
HKM25_RS02350	COG2723	6-phospho-beta-galactosidase activity
HKM25_RS02355	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HKM25_RS02355	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HKM25_RS02360	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HKM25_RS02365	COG0569	domain protein
HKM25_RS02385	COG1122	ATPase activity
HKM25_RS02400	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HKM25_RS02405	COG0671	phosphoesterase, PA-phosphatase related
HKM25_RS02415	COG1247	-acetyltransferase
HKM25_RS02425	COG0504	CTP synthase activity
HKM25_RS02430	COG1283	sodium-dependent phosphate transmembrane transporter activity
HKM25_RS02450	COG0789	Transcriptional regulator
HKM25_RS02455	COG0174	glutamine synthetase
HKM25_RS02475	COG4974	Belongs to the 'phage' integrase family
HKM25_RS02515	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HKM25_RS02530	COG0484	heat shock protein binding
HKM25_RS02545	COG0537	adenosine 5'-monophosphoramidase activity
HKM25_RS02550	COG1131	(ABC) transporter
HKM25_RS02575	COG3290	protein histidine kinase activity
HKM25_RS02585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKM25_RS02590	COG2274	protein secretion by the type I secretion system
HKM25_RS02640	COG1266	CAAX protease self-immunity
HKM25_RS02660	COG0195	Participates in both transcription termination and antitermination
HKM25_RS02665	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HKM25_RS02725	COG0519	Catalyzes the synthesis of GMP from XMP
HKM25_RS02735	COG0525	valine-tRNA ligase activity
HKM25_RS02770	COG3711	transcriptional antiterminator
HKM25_RS02775	COG2190	(PTS) system
HKM25_RS02775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKM25_RS02775	COG1263	PTS System
HKM25_RS02790	COG0456	acetyltransferase
HKM25_RS02795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HKM25_RS02795	COG0072	phenylalanine-tRNA ligase activity
HKM25_RS02810	COG3620	sequence-specific DNA binding
HKM25_RS02815	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HKM25_RS02825	COG1185	polyribonucleotide nucleotidyltransferase activity
HKM25_RS02830	COG1045	serine acetyltransferase
HKM25_RS02840	COG0215	cysteine-tRNA ligase activity
HKM25_RS02845	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HKM25_RS02870	COG0577	efflux transmembrane transporter activity
HKM25_RS02875	COG1136	(ABC) transporter
HKM25_RS02880	COG0577	efflux transmembrane transporter activity
HKM25_RS02885	COG0745	RESPONSE REGULATOR receiver
HKM25_RS02890	COG5002	protein histidine kinase activity
HKM25_RS02895	COG0191	fructose-bisphosphate aldolase activity
HKM25_RS02905	COG0765	amino acid transport
HKM25_RS02910	COG0765	amino acid transport
HKM25_RS02915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKM25_RS02925	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HKM25_RS02925	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HKM25_RS02965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKM25_RS02980	COG1573	uracil-dna glycosylase
HKM25_RS02990	COG1114	Component of the transport system for branched-chain amino acids
HKM25_RS02995	COG1363	Peptidase, m42
HKM25_RS03035	COG4555	ABC transporter
HKM25_RS03065	COG1404	Belongs to the peptidase S8 family
HKM25_RS03080	COG3775	system Galactitol-specific IIC component
HKM25_RS03090	COG3250	beta-galactosidase activity
HKM25_RS03110	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HKM25_RS03130	COG0785	Cytochrome C biogenesis protein
HKM25_RS03135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HKM25_RS03140	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HKM25_RS03140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HKM25_RS03145	COG4753	response regulator
HKM25_RS03145	COG2207	Transcriptional regulator
HKM25_RS03150	COG2972	Histidine kinase
HKM25_RS03155	COG4475	Protein of unknown function (DUF436)
HKM25_RS03160	COG3064	Membrane
HKM25_RS03165	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HKM25_RS03180	COG1940	carbohydrate kinase activity
HKM25_RS03195	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HKM25_RS03205	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HKM25_RS03215	COG0300	oxidoreductase activity
HKM25_RS03230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HKM25_RS03245	COG1187	pseudouridine synthase activity
HKM25_RS03280	COG1136	(ABC) transporter
HKM25_RS03285	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HKM25_RS03295	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HKM25_RS03305	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HKM25_RS03330	COG1131	(ABC) transporter
HKM25_RS03335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKM25_RS03345	COG0765	amino acid transport
HKM25_RS03355	COG1304	FMN binding
HKM25_RS03365	COG1304	FMN binding
HKM25_RS03380	COG0352	thiamine-phosphate diphosphorylase activity
HKM25_RS03390	COG4172	Belongs to the ABC transporter superfamily
HKM25_RS03400	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HKM25_RS03415	COG0352	thiamine-phosphate diphosphorylase activity
HKM25_RS03435	COG2217	Heavy metal translocating P-type atpase
HKM25_RS03440	COG0028	Belongs to the TPP enzyme family
HKM25_RS03455	COG2723	6-phospho-beta-galactosidase activity
HKM25_RS03460	COG1482	cell wall glycoprotein biosynthetic process
HKM25_RS03465	COG0733	neurotransmitter:sodium symporter activity
HKM25_RS03470	COG0789	Transcriptional regulator
HKM25_RS03495	COG1307	EDD domain protein, DegV family
HKM25_RS03505	COG2131	deaminase
HKM25_RS03510	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HKM25_RS03550	COG0517	IMP dehydrogenase activity
HKM25_RS03550	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HKM25_RS03550	COG0617	tRNA 3'-terminal CCA addition
HKM25_RS03560	COG2884	Cell division ATP-binding protein ftsE
HKM25_RS03565	COG2177	Part of the ABC transporter FtsEX involved in
HKM25_RS03570	COG2190	(PTS) system
HKM25_RS03570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKM25_RS03570	COG1263	PTS System
HKM25_RS03580	COG0513	Belongs to the DEAD box helicase family
HKM25_RS03590	COG0167	dihydroorotate dehydrogenase activity
HKM25_RS03600	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HKM25_RS03605	COG4470	Protein conserved in bacteria
HKM25_RS03620	COG0488	(ABC) transporter
HKM25_RS03645	COG1837	Belongs to the UPF0109 family
HKM25_RS03665	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HKM25_RS03665	COG1328	CTP reductase activity
HKM25_RS03675	COG4443	Transcriptional Coactivator p15 (PC4)
HKM25_RS03685	COG1268	BioY protein
HKM25_RS03690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKM25_RS03695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKM25_RS03700	COG1136	(ABC) transporter
HKM25_RS03705	COG0577	efflux transmembrane transporter activity
HKM25_RS03710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HKM25_RS03710	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HKM25_RS03730	COG4989	oxidoreductase activity
HKM25_RS03740	COG1028	Short-chain dehydrogenase reductase Sdr
HKM25_RS03770	COG0745	RESPONSE REGULATOR receiver
HKM25_RS03775	COG5002	protein histidine kinase activity
HKM25_RS03795	COG0772	Belongs to the SEDS family
HKM25_RS03800	COG0693	protein deglycase activity
HKM25_RS03810	COG0187	DNA topoisomerase II activity
HKM25_RS03830	COG0494	nUDIX hydrolase
HKM25_RS03840	COG0542	response to heat
HKM25_RS03845	COG4703	Protein of unknown function (DUF1797)
HKM25_RS03850	COG0765	amino acid transport
HKM25_RS03855	COG1126	abc transporter atp-binding protein
HKM25_RS03860	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HKM25_RS03865	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HKM25_RS03885	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HKM25_RS03910	COG0268	Binds directly to 16S ribosomal RNA
HKM25_RS03925	COG2813	Specifically methylates the guanine in position
HKM25_RS03930	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HKM25_RS03940	COG0295	cytidine deaminase activity
HKM25_RS03945	COG1744	ABC transporter substrate-binding protein PnrA-like
HKM25_RS03975	COG0187	DNA topoisomerase II activity
HKM25_RS03980	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HKM25_RS03985	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HKM25_RS03990	COG4166	transmembrane transport
HKM25_RS04025	COG0539	negative regulation of cytoplasmic translation
HKM25_RS04035	COG1956	GAF domain-containing protein
HKM25_RS04040	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HKM25_RS04055	COG0719	Fe-S assembly protein
HKM25_RS04060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HKM25_RS04070	COG0719	Fe-S assembly protein
HKM25_RS04075	COG1686	Belongs to the peptidase S11 family
HKM25_RS04080	COG0628	permease
HKM25_RS04110	COG1349	DNA-binding transcription factor activity
HKM25_RS04115	COG1105	Belongs to the carbohydrate kinase PfkB family
HKM25_RS04120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKM25_RS04120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKM25_RS04120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKM25_RS04125	COG1674	ftsk spoiiie
HKM25_RS04125	COG0697	spore germination
HKM25_RS04135	COG1136	(ABC) transporter
HKM25_RS04145	COG1104	cysteine desulfurase activity
HKM25_RS04200	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HKM25_RS04205	COG1438	arginine binding
HKM25_RS04225	COG0469	pyruvate kinase activity
HKM25_RS04265	COG3689	TIGRFAM TIGR03943 family protein
HKM25_RS04270	COG0701	Predicted permease
HKM25_RS04275	COG3955	Domain of unknown function (DUF1919)
HKM25_RS04280	COG2183	response to ionizing radiation
HKM25_RS04300	COG1136	(ABC) transporter
HKM25_RS04305	COG0577	efflux transmembrane transporter activity
HKM25_RS04320	COG1982	Orn Lys Arg decarboxylase major
HKM25_RS04330	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HKM25_RS04350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HKM25_RS04355	COG0561	phosphatase activity
HKM25_RS04375	COG0583	DNA-binding transcription factor activity
HKM25_RS04380	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HKM25_RS04385	COG0564	pseudouridine synthase activity
HKM25_RS04405	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HKM25_RS04415	COG0470	DNA polymerase III
HKM25_RS04465	COG0528	UMP kinase activity
HKM25_RS04475	COG2996	Protein conserved in bacteria
HKM25_RS04485	COG1702	phosphate starvation-inducible protein PhoH
HKM25_RS04510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HKM25_RS04515	COG1555	photosystem II stabilization
HKM25_RS04515	COG1596	polysaccharide export
HKM25_RS04520	COG2333	competence protein COMEC
HKM25_RS04520	COG0658	competence protein
HKM25_RS04530	COG1131	(ABC) transporter
HKM25_RS04560	COG0543	2 iron, 2 sulfur cluster binding
HKM25_RS04565	COG0167	dihydroorotate dehydrogenase activity
HKM25_RS04570	COG5263	repeat protein
HKM25_RS04570	COG4193	domain, Protein
HKM25_RS04575	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HKM25_RS04585	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HKM25_RS04595	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HKM25_RS04600	COG0237	dephospho-CoA kinase activity
HKM25_RS04605	COG2814	Major facilitator Superfamily
HKM25_RS04610	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HKM25_RS04620	COG0557	exoribonuclease II activity
HKM25_RS04630	COG3615	Tellurite resistance protein tehB
HKM25_RS04630	COG0500	methyltransferase
HKM25_RS04645	COG4122	O-methyltransferase activity
HKM25_RS04670	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HKM25_RS04690	COG0494	nUDIX hydrolase
HKM25_RS04700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HKM25_RS04710	COG2176	DNA-directed DNA polymerase activity
HKM25_RS04715	COG0584	glycerophosphoryl diester phosphodiesterase
HKM25_RS04735	COG0785	Cytochrome C biogenesis protein
HKM25_RS04740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HKM25_RS04745	COG0531	amino acid
HKM25_RS04750	COG3443	Belongs to the bacterial solute-binding protein 9 family
HKM25_RS04750	COG0803	Belongs to the bacterial solute-binding protein 9 family
HKM25_RS04785	COG2195	Cleaves the N-terminal amino acid of tripeptides
HKM25_RS04795	COG1970	mechanosensitive ion channel activity
HKM25_RS04805	COG4708	membrane
HKM25_RS04815	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HKM25_RS04830	COG1942	4-Oxalocrotonate Tautomerase
HKM25_RS04835	COG1435	thymidine kinase activity
HKM25_RS04870	COG0741	lytic transglycosylase activity
HKM25_RS04880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HKM25_RS04900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKM25_RS04905	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKM25_RS04965	COG1597	lipid kinase activity
HKM25_RS04980	COG1396	sequence-specific DNA binding
HKM25_RS04985	COG0542	response to heat
HKM25_RS05010	COG3843	relaxase mobilization nuclease domain protein
HKM25_RS05060	COG0318	PFAM AMP-dependent synthetase and ligase
HKM25_RS05105	COG0772	Belongs to the SEDS family
HKM25_RS05110	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HKM25_RS05125	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HKM25_RS05130	COG0358	DNA primase activity
HKM25_RS05135	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HKM25_RS05140	COG2151	metal-sulfur cluster biosynthetic enzyme
HKM25_RS05145	COG0438	transferase activity, transferring glycosyl groups
HKM25_RS05150	COG0438	transferase activity, transferring glycosyl groups
HKM25_RS05175	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HKM25_RS05185	COG4109	DRTGG domain
HKM25_RS05190	COG0024	Methionine aminopeptidase
HKM25_RS05205	COG0210	DNA helicase
HKM25_RS05215	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HKM25_RS05235	COG1104	cysteine desulfurase activity
HKM25_RS05240	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HKM25_RS05250	COG2357	RelA SpoT domain protein
HKM25_RS05260	COG0564	pseudouridine synthase activity
HKM25_RS05265	COG0280	phosphate acetyltransferase
HKM25_RS05305	COG0196	riboflavin kinase activity
HKM25_RS05310	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HKM25_RS05315	COG1307	EDD domain protein, DegV family
HKM25_RS05325	COG0488	(ABC) transporter
HKM25_RS05345	COG1523	belongs to the glycosyl hydrolase 13 family
HKM25_RS05350	COG1012	belongs to the aldehyde dehydrogenase family
HKM25_RS05355	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HKM25_RS05365	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HKM25_RS05375	COG0560	Phosphoserine phosphatase
HKM25_RS05380	COG0560	Phosphoserine phosphatase
HKM25_RS05400	COG0582	viral genome integration into host DNA
HKM25_RS05440	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HKM25_RS05445	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HKM25_RS05460	COG0095	Lipoate-protein ligase
HKM25_RS05465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKM25_RS05470	COG0508	dehydrogenase complex catalyzes the overall conversion of
HKM25_RS05475	COG0022	dehydrogenase e1 component
HKM25_RS05480	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HKM25_RS05485	COG0534	Mate efflux family protein
HKM25_RS05495	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HKM25_RS05500	COG1051	belongs to the nudix hydrolase family
HKM25_RS05515	COG1011	Hydrolase
HKM25_RS05525	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HKM25_RS05545	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKM25_RS05550	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HKM25_RS05555	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKM25_RS05560	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKM25_RS05590	COG3711	transcriptional antiterminator
HKM25_RS05595	COG3684	Belongs to the aldolase LacD family
HKM25_RS05645	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HKM25_RS05650	COG0497	DNA recombination
HKM25_RS05655	COG1438	arginine binding
HKM25_RS05660	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HKM25_RS05690	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HKM25_RS05700	COG2873	o-acetylhomoserine
HKM25_RS05715	COG3764	Sortase (surface protein transpeptidase)
HKM25_RS05720	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HKM25_RS05750	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HKM25_RS05755	COG5002	protein histidine kinase activity
HKM25_RS05760	COG0745	RESPONSE REGULATOR receiver
HKM25_RS05765	COG1194	a g-specific adenine glycosylase
HKM25_RS05780	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HKM25_RS05785	COG4684	Psort location CytoplasmicMembrane, score
HKM25_RS05795	COG1827	regulation of RNA biosynthetic process
HKM25_RS05825	COG0765	amino acid transport
HKM25_RS05830	COG1126	abc transporter atp-binding protein
HKM25_RS05835	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HKM25_RS05840	COG0552	protein localization to endoplasmic reticulum
HKM25_RS05845	COG0561	phosphatase activity
HKM25_RS05850	COG0561	phosphatase activity
HKM25_RS05855	COG1196	nuclear chromosome segregation
HKM25_RS05880	COG1401	restriction endodeoxyribonuclease activity
HKM25_RS05890	COG0066	3-isopropylmalate dehydratase activity
HKM25_RS05900	COG0473	3-isopropylmalate dehydrogenase activity
HKM25_RS05915	COG3142	Participates in the control of copper homeostasis
HKM25_RS05920	COG2832	Protein of unknown function (DUF454)
HKM25_RS05925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HKM25_RS05935	COG0758	DNA mediated transformation
HKM25_RS05940	COG4750	Nucleotidyl transferase
HKM25_RS05955	COG1063	alcohol dehydrogenase
HKM25_RS05960	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HKM25_RS05970	COG3475	LICD family
HKM25_RS05975	COG3475	LICD family
HKM25_RS05985	COG0505	Belongs to the CarA family
HKM25_RS06000	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HKM25_RS06015	COG0488	(ABC) transporter
HKM25_RS06025	COG1704	LemA family
HKM25_RS06040	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HKM25_RS06055	COG1078	dGTPase activity
HKM25_RS06075	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HKM25_RS06080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HKM25_RS06085	COG1605	Chorismate mutase
HKM25_RS06085	COG0077	Prephenate dehydratase
HKM25_RS06090	COG0716	FMN binding
HKM25_RS06095	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HKM25_RS06120	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HKM25_RS06160	COG2081	HI0933 family
HKM25_RS06175	COG0395	ABC-type sugar transport system, permease component
HKM25_RS06180	COG4209	transmembrane transport
HKM25_RS06185	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HKM25_RS06215	COG0577	efflux transmembrane transporter activity
HKM25_RS06215	COG1136	(ABC) transporter
HKM25_RS06225	COG1770	oligopeptidase
HKM25_RS06230	COG0515	serine threonine protein kinase
HKM25_RS06280	COG0402	S-adenosylhomocysteine deaminase activity
HKM25_RS06295	COG1132	(ABC) transporter
HKM25_RS06300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HKM25_RS06300	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HKM25_RS06335	COG1215	transferase activity, transferring glycosyl groups
HKM25_RS06345	COG3475	LICD family
HKM25_RS06355	COG0077	Prephenate dehydratase
HKM25_RS06360	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HKM25_RS06375	COG0287	Prephenate dehydrogenase
HKM25_RS06400	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HKM25_RS06410	COG1131	(ABC) transporter
HKM25_RS06450	COG3842	ATPase activity
HKM25_RS06465	COG3527	Alpha-acetolactate decarboxylase
HKM25_RS06470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKM25_RS06475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKM25_RS06485	COG0704	Plays a role in the regulation of phosphate uptake
HKM25_RS06490	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HKM25_RS06495	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HKM25_RS06500	COG0581	inorganic phosphate transmembrane transporter activity
HKM25_RS06505	COG0573	inorganic phosphate transmembrane transporter activity
HKM25_RS06510	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HKM25_RS06515	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HKM25_RS06515	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HKM25_RS06520	COG0483	inositol monophosphate 1-phosphatase activity
HKM25_RS06530	COG1393	Belongs to the ArsC family
HKM25_RS06540	COG0647	UMP catabolic process
HKM25_RS06550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HKM25_RS06605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HKM25_RS06615	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HKM25_RS06640	COG1131	(ABC) transporter
HKM25_RS06680	COG1132	(ABC) transporter
HKM25_RS06685	COG1132	(ABC) transporter
HKM25_RS06700	COG1129	ABC transporter
HKM25_RS06735	COG2188	Transcriptional regulator
HKM25_RS06740	COG0697	spore germination
HKM25_RS06745	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HKM25_RS06760	COG0561	phosphatase activity
HKM25_RS06785	COG0492	ferredoxin-NADP+ reductase activity
HKM25_RS06795	COG1126	abc transporter atp-binding protein
HKM25_RS06805	COG1393	Belongs to the ArsC family
HKM25_RS06810	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HKM25_RS06825	COG1272	protein, Hemolysin III
HKM25_RS06855	COG1053	succinate dehydrogenase
HKM25_RS06855	COG0431	NADPH-dependent FMN reductase
HKM25_RS06855	COG3976	FMN-binding domain protein
HKM25_RS06880	COG0656	L-ascorbic acid biosynthetic process
HKM25_RS06885	COG0726	polysaccharide deacetylase
HKM25_RS06915	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HKM25_RS06945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKM25_RS06960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKM25_RS06965	COG1126	abc transporter atp-binding protein
HKM25_RS06975	COG0457	Tetratricopeptide repeat
HKM25_RS06980	COG0628	permease
HKM25_RS06985	COG2706	6-phosphogluconolactonase activity
HKM25_RS07040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HKM25_RS07045	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HKM25_RS07070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HKM25_RS07075	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HKM25_RS07080	COG0626	cystathionine gamma-synthase activity
HKM25_RS07085	COG1132	(ABC) transporter
HKM25_RS07090	COG4166	transmembrane transport
HKM25_RS07095	COG2244	polysaccharide biosynthetic process
HKM25_RS07100	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HKM25_RS07125	COG2827	Endonuclease containing a URI domain
HKM25_RS07130	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HKM25_RS07135	COG1098	S1 RNA binding domain
HKM25_RS07145	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HKM25_RS07150	COG0629	single-stranded DNA binding
HKM25_RS07160	COG0017	Asparaginyl-tRNA synthetase
HKM25_RS07170	COG0436	Aminotransferase
HKM25_RS07190	COG3711	transcriptional antiterminator
HKM25_RS07210	COG0242	peptide deformylase activity
HKM25_RS07215	COG0625	glutathione transferase activity
HKM25_RS07225	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HKM25_RS07230	COG0488	(ABC) transporter
HKM25_RS07245	COG1307	EDD domain protein, DegV family
HKM25_RS07265	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HKM25_RS07275	COG5263	repeat protein
HKM25_RS07275	COG5632	N-Acetylmuramoyl-L-alanine amidase
HKM25_RS07380	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HKM25_RS07565	COG0582	viral genome integration into host DNA
HKM25_RS07570	COG5632	N-Acetylmuramoyl-L-alanine amidase
HKM25_RS07570	COG5263	repeat protein
HKM25_RS07675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HKM25_RS07725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HKM25_RS07910	COG0582	viral genome integration into host DNA
HKM25_RS07915	COG1481	regulation of sporulation
HKM25_RS07920	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HKM25_RS07930	COG0251	oxidation-reduction process
HKM25_RS07950	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HKM25_RS07960	COG5263	repeat protein
HKM25_RS07960	COG4193	domain, Protein
HKM25_RS07970	COG3935	DnaD domain protein
HKM25_RS07985	COG2226	methyltransferase
HKM25_RS07995	COG3842	ATPase activity
HKM25_RS08005	COG1335	isochorismatase
HKM25_RS08015	COG0513	Belongs to the DEAD box helicase family
HKM25_RS08020	COG2223	nitrite transmembrane transporter activity
HKM25_RS08025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKM25_RS08030	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HKM25_RS08035	COG3442	glutamine amidotransferase
HKM25_RS08040	COG0006	proline dipeptidase activity
HKM25_RS08055	COG4720	Psort location CytoplasmicMembrane, score
HKM25_RS08060	COG0351	phosphomethylpyrimidine kinase
HKM25_RS08080	COG2824	Alkylphosphonate utilization operon protein PhnA
HKM25_RS08100	COG0463	Glycosyl transferase, family 2
HKM25_RS08105	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HKM25_RS08115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKM25_RS08120	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HKM25_RS08125	COG2384	SAM-dependent methyltransferase
HKM25_RS08130	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HKM25_RS08135	COG0204	Acyl-transferase
HKM25_RS08155	COG2910	NAD(P)H-binding
HKM25_RS08175	COG5002	protein histidine kinase activity
HKM25_RS08180	COG0745	RESPONSE REGULATOR receiver
HKM25_RS08195	COG1959	2 iron, 2 sulfur cluster binding
HKM25_RS08240	COG3590	peptidase
HKM25_RS08255	COG0803	Belongs to the bacterial solute-binding protein 9 family
HKM25_RS08260	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HKM25_RS08270	COG1136	(ABC) transporter
HKM25_RS08270	COG0577	efflux transmembrane transporter activity
HKM25_RS08300	COG3599	regulation of cell shape
HKM25_RS08320	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HKM25_RS08340	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HKM25_RS08355	COG0768	penicillin binding
HKM25_RS08370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKM25_RS08385	COG2731	YhcH YjgK YiaL family protein
HKM25_RS08390	COG0395	ABC-type sugar transport system, permease component
HKM25_RS08395	COG1175	transmembrane transport
HKM25_RS08405	COG2190	(PTS) system
HKM25_RS08405	COG1263	PTS System
HKM25_RS08405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKM25_RS08415	COG0673	inositol 2-dehydrogenase activity
HKM25_RS08420	COG4409	exo-alpha-(2->6)-sialidase activity
HKM25_RS08430	COG1175	transmembrane transport
HKM25_RS08435	COG1653	transport
HKM25_RS08460	COG3458	cephalosporin-C deacetylase activity
HKM25_RS08465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HKM25_RS08480	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HKM25_RS08485	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HKM25_RS08500	COG1131	(ABC) transporter
HKM25_RS08545	COG1484	DNA-dependent DNA replication
HKM25_RS08560	COG1725	Transcriptional regulator
HKM25_RS08565	COG1131	(ABC) transporter
HKM25_RS08575	COG1668	transmembrane transport
HKM25_RS08580	COG4152	abc transporter atp-binding protein
HKM25_RS08600	COG1940	carbohydrate kinase activity
HKM25_RS08605	COG2190	(PTS) system
HKM25_RS08605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKM25_RS08605	COG1263	PTS System
HKM25_RS08610	COG1621	beta-fructofuranosidase activity
HKM25_RS08615	COG1609	Transcriptional regulator
HKM25_RS08625	COG3425	synthase
HKM25_RS08650	COG2815	serine threonine protein kinase
HKM25_RS08650	COG0515	serine threonine protein kinase
HKM25_RS08655	COG0631	protein serine/threonine phosphatase activity
HKM25_RS08660	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HKM25_RS08660	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HKM25_RS08670	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HKM25_RS08680	COG0194	GDP metabolic process
HKM25_RS08700	COG2226	methyltransferase
HKM25_RS08705	COG0799	negative regulation of ribosome biogenesis
HKM25_RS08715	COG1713	HD superfamily hydrolase involved in NAD metabolism
HKM25_RS08720	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HKM25_RS08725	COG1534	Rna-binding protein
HKM25_RS08730	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HKM25_RS08745	COG0668	transmembrane transport
HKM25_RS08775	COG0438	transferase activity, transferring glycosyl groups
HKM25_RS08780	COG0438	transferase activity, transferring glycosyl groups
HKM25_RS08785	COG0653	protein targeting
HKM25_RS08810	COG1215	transferase activity, transferring glycosyl groups
HKM25_RS08820	COG1442	glycosyl transferase family 8
HKM25_RS08825	COG1442	glycosyl transferase family 8
HKM25_RS08830	COG1442	glycosyl transferase family 8
HKM25_RS08830	COG1216	Glycosyl transferase, family 2
HKM25_RS08835	COG1442	glycosyl transferase family 8
HKM25_RS08840	COG0438	transferase activity, transferring glycosyl groups
HKM25_RS08845	COG1442	glycosyl transferase family 8
HKM25_RS08855	COG1442	glycosyl transferase family 8
HKM25_RS08860	COG1442	glycosyl transferase family 8
HKM25_RS08865	COG1216	Glycosyl transferase, family 2
HKM25_RS08865	COG1442	glycosyl transferase family 8
HKM25_RS08895	COG3118	belongs to the thioredoxin family
HKM25_RS08900	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HKM25_RS08910	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HKM25_RS08920	COG1164	Oligoendopeptidase f
HKM25_RS08925	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HKM25_RS08935	COG1051	belongs to the nudix hydrolase family
HKM25_RS08970	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HKM25_RS08980	COG1621	beta-fructofuranosidase activity
HKM25_RS08985	COG1653	transport
HKM25_RS08990	COG0395	ABC-type sugar transport system, permease component
HKM25_RS08995	COG4209	transmembrane transport
HKM25_RS09005	COG3711	transcriptional antiterminator
HKM25_RS09010	COG2261	transglycosylase associated protein
HKM25_RS09030	COG3237	CsbD-like
HKM25_RS09075	COG0135	phosphoribosylanthranilate isomerase activity
HKM25_RS09090	COG0512	Glutamine amidotransferase of anthranilate synthase
HKM25_RS09095	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HKM25_RS09115	COG1285	pathogenesis
HKM25_RS09120	COG1178	ABC-type Fe3 transport system permease component
HKM25_RS09140	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HKM25_RS09145	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HKM25_RS09150	COG0704	Plays a role in the regulation of phosphate uptake
HKM25_RS09165	COG5434	Belongs to the glycosyl hydrolase 28 family
HKM25_RS09170	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HKM25_RS09175	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HKM25_RS09180	COG1132	(ABC) transporter
HKM25_RS09185	COG1132	(ABC) transporter
HKM25_RS09200	COG0708	Exodeoxyribonuclease III
HKM25_RS09220	COG2233	PERMEase
HKM25_RS09245	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HKM25_RS09250	COG1609	Transcriptional regulator
HKM25_RS09255	COG1063	alcohol dehydrogenase
HKM25_RS09260	COG0789	Transcriptional regulator
HKM25_RS09265	COG1230	cation diffusion facilitator family transporter
HKM25_RS09275	COG3201	nicotinamide mononucleotide transporter
HKM25_RS09280	COG1174	glycine betaine transport
HKM25_RS09305	COG1363	Peptidase, m42
HKM25_RS09315	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKM25_RS09320	COG4605	iron ion homeostasis
HKM25_RS09325	COG4604	ABC transporter, ATP-binding protein
HKM25_RS09330	COG4607	ABC-type enterochelin transport system periplasmic component
HKM25_RS09340	COG1187	pseudouridine synthase activity
HKM25_RS09360	COG0517	IMP dehydrogenase activity
HKM25_RS09370	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HKM25_RS09385	COG0366	Alpha amylase catalytic
HKM25_RS09390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKM25_RS09390	COG1263	PTS System
HKM25_RS09395	COG2188	Transcriptional regulator
HKM25_RS09405	COG4608	Belongs to the ABC transporter superfamily
HKM25_RS09410	COG0444	Belongs to the ABC transporter superfamily
HKM25_RS09415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HKM25_RS09420	COG0601	transmembrane transport
HKM25_RS09425	COG4166	transmembrane transport
HKM25_RS09435	COG0366	Alpha amylase catalytic
HKM25_RS09440	COG0395	ABC-type sugar transport system, permease component
HKM25_RS09445	COG1175	transmembrane transport
HKM25_RS09450	COG1653	transport
HKM25_RS09455	COG3345	alpha-galactosidase
HKM25_RS09460	COG2207	Transcriptional regulator
HKM25_RS09465	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HKM25_RS09465	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HKM25_RS09580	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HKM25_RS09585	COG3231	kanamycin kinase activity
HKM25_RS09635	COG4221	oxidoreductase activity
HKM25_RS09640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HKM25_RS09645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HKM25_RS09755	COG5263	repeat protein
HKM25_RS09755	COG5632	N-Acetylmuramoyl-L-alanine amidase
HKM25_RS09775	COG1316	TRANSCRIPTIONal
HKM25_RS09785	COG0802	atpase or kinase
HKM25_RS09805	COG0577	efflux transmembrane transporter activity
HKM25_RS09805	COG1136	(ABC) transporter
HKM25_RS09835	COG1253	flavin adenine dinucleotide binding
HKM25_RS09850	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HKM25_RS09860	COG3480	Lon protease (S16) C-terminal proteolytic domain
HKM25_RS09870	COG0742	ribosomal rna small subunit methyltransferase
HKM25_RS09885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HKM25_RS09890	COG1254	Belongs to the acylphosphatase family
HKM25_RS09895	COG0706	membrane insertase activity
HKM25_RS09900	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HKM25_RS09910	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HKM25_RS09925	COG1564	THIamine pyrophosphokinase
HKM25_RS09935	COG1162	GTPase activity
HKM25_RS09940	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HKM25_RS09970	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HKM25_RS09975	COG0084	hydrolase, TatD family'
HKM25_RS09995	COG0436	Aminotransferase
HKM25_RS10005	COG0589	response to stress
HKM25_RS10010	COG0561	phosphatase activity
HKM25_RS10015	COG0252	asparaginase activity
HKM25_RS10025	COG1609	Transcriptional regulator
HKM25_RS10030	COG2197	response regulator
HKM25_RS10035	COG4585	Histidine kinase
HKM25_RS10040	COG0842	Transport permease protein
HKM25_RS10045	COG1131	(ABC) transporter
HKM25_RS10145	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HKM25_RS10150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HKM25_RS10155	COG0564	pseudouridine synthase activity
HKM25_RS10175	COG0157	Belongs to the NadC ModD family
HKM25_RS10185	COG1129	ABC transporter
HKM25_RS10190	COG2188	Transcriptional regulator
HKM25_RS10195	COG2723	6-phospho-beta-galactosidase activity
HKM25_RS10200	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HKM25_RS10210	COG1447	Phosphotransferase system cellobiose-specific component IIA
HKM25_RS10215	COG1454	alcohol dehydrogenase
HKM25_RS10215	COG1012	belongs to the aldehyde dehydrogenase family
HKM25_RS10225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HKM25_RS10235	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HKM25_RS10255	COG3623	hexulose-6-phosphate isomerase
HKM25_RS10265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKM25_RS10275	COG3037	sugar-specific permease SgaT UlaA
HKM25_RS10285	COG1847	R3H domain protein
HKM25_RS10290	COG0706	membrane insertase activity
HKM25_RS10335	COG4537	Required for transformation and DNA binding
HKM25_RS10340	COG1459	type II secretion system
HKM25_RS10345	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HKM25_RS10355	COG1063	alcohol dehydrogenase
HKM25_RS10385	COG3759	membrane
HKM25_RS10400	COG0131	Imidazoleglycerol-phosphate dehydratase
HKM25_RS10400	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HKM25_RS10405	COG0534	Mate efflux family protein
HKM25_RS10435	COG0582	viral genome integration into host DNA
HKM25_RS10450	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HKM25_RS10555	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HKM25_RS10560	COG1132	(ABC) transporter
HKM25_RS10570	COG1132	(ABC) transporter
HKM25_RS10580	COG1438	arginine binding
HKM25_RS10600	COG0745	RESPONSE REGULATOR receiver
HKM25_RS10605	COG5002	protein histidine kinase activity
HKM25_RS10610	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HKM25_RS10615	COG0573	inorganic phosphate transmembrane transporter activity
HKM25_RS10625	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HKM25_RS10630	COG0704	Plays a role in the regulation of phosphate uptake
HKM25_RS10650	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HKM25_RS10660	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HKM25_RS10675	COG0697	spore germination
HKM25_RS10680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HKM25_RS10680	COG4499	WXG100 protein secretion system (Wss), protein YukC
HKM25_RS10690	COG2217	Heavy metal translocating P-type atpase
HKM25_RS10700	COG2226	methyltransferase
HKM25_RS10710	COG0058	SHG alpha-glucan phosphorylase activity
HKM25_RS10715	COG1640	4-alpha-glucanotransferase
HKM25_RS10720	COG2182	Extracellular solute-binding protein
HKM25_RS10725	COG1175	transmembrane transport
HKM25_RS10730	COG3833	ABC-type maltose transport systems, permease component
HKM25_RS10735	COG5521	maltodextrose utilization protein MalA
HKM25_RS10740	COG1609	Transcriptional regulator
HKM25_RS10750	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HKM25_RS10755	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HKM25_RS10785	COG1476	TRANSCRIPTIONal
HKM25_RS10815	COG2151	metal-sulfur cluster biosynthetic enzyme
HKM25_RS10830	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HKM25_RS10835	COG3959	Transketolase, thiamine diphosphate binding domain
HKM25_RS10850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKM25_RS10870	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HKM25_RS10905	COG0383	alpha-mannosidase activity
HKM25_RS10915	COG3537	Alpha-1,2-mannosidase
HKM25_RS10935	COG0549	Belongs to the carbamate kinase family
HKM25_RS10940	COG1288	antiporter activity
HKM25_RS10945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HKM25_RS10955	COG3583	domain protein
HKM25_RS10955	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HKM25_RS10955	COG3064	Membrane
HKM25_RS10970	COG1454	alcohol dehydrogenase
HKM25_RS10990	COG3716	PTS system mannose fructose sorbose family IID component
HKM25_RS11000	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKM25_RS11020	COG1070	Carbohydrate kinase
HKM25_RS11030	COG0803	Belongs to the bacterial solute-binding protein 9 family
HKM25_RS11030	COG3443	Belongs to the bacterial solute-binding protein 9 family
HKM25_RS11035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HKM25_RS11040	COG1121	(ABC) transporter
HKM25_RS11045	COG1846	Transcriptional regulator
HKM25_RS11050	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HKM25_RS11060	COG1696	Membrane protein involved in D-alanine export
HKM25_RS11075	COG2211	Major facilitator Superfamily
HKM25_RS11085	COG3344	reverse transcriptase
HKM25_RS11100	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HKM25_RS11105	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HKM25_RS11125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HKM25_RS11135	COG1755	Isoprenylcysteine carboxyl methyltransferase
HKM25_RS11140	COG5002	protein histidine kinase activity
HKM25_RS11145	COG0745	RESPONSE REGULATOR receiver
HKM25_RS11150	COG0542	response to heat
HKM25_RS11155	COG4463	regulation of RNA biosynthetic process
HKM25_RS11160	COG1116	anion transmembrane transporter activity
HKM25_RS11165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKM25_RS11170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKM25_RS11190	COG0305	Participates in initiation and elongation during chromosome replication
HKM25_RS11210	COG1040	competence protein
HKM25_RS11215	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HKM25_RS11220	COG1739	Uncharacterized protein family UPF0029
HKM25_RS11240	COG3942	CHAP domain
HKM25_RS11250	COG1792	Involved in formation and maintenance of cell shape
HKM25_RS11255	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HKM25_RS11260	COG1122	ATPase activity
HKM25_RS11265	COG1122	ATPase activity
HKM25_RS11270	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HKM25_RS11280	COG0612	Peptidase, M16
HKM25_RS11285	COG0612	Peptidase, M16
HKM25_RS11290	COG2501	S4 domain
HKM25_RS11300	COG0516	GMP reductase activity
HKM25_RS11300	COG0517	IMP dehydrogenase activity
HKM25_RS11305	COG0180	Tryptophanyl-tRNA synthetase
HKM25_RS11310	COG0488	(ABC) transporter
HKM25_RS11320	COG1511	domain protein
HKM25_RS11330	COG1511	domain protein
HKM25_RS11375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HKM25_RS11380	COG1475	DNA binding