locus-tag	class	description
SPAP_RS00010	COG0592	DNA-directed DNA polymerase activity
SPAP_RS00020	COG0012	GTP binding
SPAP_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPAP_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPAP_RS00060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SPAP_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPAP_RS00230	COG0582	viral genome integration into host DNA
SPAP_RS00335	COG5263	repeat protein
SPAP_RS00335	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPAP_RS00350	COG0756	dUTP diphosphatase activity
SPAP_RS00360	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SPAP_RS00380	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPAP_RS00400	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPAP_RS00400	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPAP_RS00405	COG1832	CoA-binding protein
SPAP_RS00415	COG2855	membrane
SPAP_RS00420	COG0436	Aminotransferase
SPAP_RS00455	COG2274	protein secretion by the type I secretion system
SPAP_RS00460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPAP_RS00470	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPAP_RS00475	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SPAP_RS00480	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SPAP_RS00485	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPAP_RS00500	COG0151	Belongs to the GarS family
SPAP_RS00505	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPAP_RS00520	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPAP_RS00525	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPAP_RS00525	COG3064	Membrane
SPAP_RS00525	COG3583	domain protein
SPAP_RS00540	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPAP_RS00545	COG3715	PTS system
SPAP_RS00550	COG3716	PTS system mannose fructose sorbose family IID component
SPAP_RS00560	COG2222	sugar isomerase
SPAP_RS00580	COG3583	domain protein
SPAP_RS00585	COG2514	catechol 2,3-dioxygenase activity
SPAP_RS00590	COG0110	maltose O-acetyltransferase activity
SPAP_RS00605	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPAP_RS00610	COG0569	domain protein
SPAP_RS00640	COG5002	protein histidine kinase activity
SPAP_RS00670	COG4209	transmembrane transport
SPAP_RS00675	COG0395	ABC-type sugar transport system, permease component
SPAP_RS00680	COG1653	transport
SPAP_RS00710	COG1695	Transcriptional regulator
SPAP_RS00735	COG0546	phosphoglycolate phosphatase activity
SPAP_RS00740	COG1760	l-serine dehydratase
SPAP_RS00745	COG1760	l-serine dehydratase
SPAP_RS00775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPAP_RS00780	COG0137	argininosuccinate synthase activity
SPAP_RS00875	COG0494	nUDIX hydrolase
SPAP_RS00880	COG0445	tRNA wobble uridine modification
SPAP_RS00910	COG1214	PFAM Peptidase M22, glycoprotease
SPAP_RS01005	COG1396	sequence-specific DNA binding
SPAP_RS01045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPAP_RS01050	COG1464	Belongs to the NlpA lipoprotein family
SPAP_RS01055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPAP_RS01060	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPAP_RS01080	COG2972	Histidine kinase
SPAP_RS01085	COG4753	response regulator
SPAP_RS01085	COG2207	Transcriptional regulator
SPAP_RS01095	COG1780	Probably involved in ribonucleotide reductase function
SPAP_RS01125	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPAP_RS01125	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPAP_RS01145	COG2818	Glycosylase
SPAP_RS01170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPAP_RS01175	COG0006	proline dipeptidase activity
SPAP_RS01180	COG1393	Belongs to the ArsC family
SPAP_RS01205	COG0285	dihydrofolate synthase activity
SPAP_RS01215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPAP_RS01245	COG0602	queuosine metabolic process
SPAP_RS01280	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPAP_RS01305	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SPAP_RS01345	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SPAP_RS01360	COG0201	protein transport
SPAP_RS01370	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SPAP_RS01375	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SPAP_RS01385	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SPAP_RS01390	COG0202	RNA polymerase activity
SPAP_RS01400	COG3830	Belongs to the UPF0237 family
SPAP_RS01425	COG3842	ATPase activity
SPAP_RS01440	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPAP_RS01445	COG1349	DNA-binding transcription factor activity
SPAP_RS01455	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPAP_RS01460	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPAP_RS01465	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPAP_RS01470	COG1882	Formate acetyltransferase
SPAP_RS01515	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPAP_RS01520	COG4589	Belongs to the CDS family
SPAP_RS01525	COG0750	zinc metalloprotease
SPAP_RS01535	COG2723	6-phospho-beta-galactosidase activity
SPAP_RS01540	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPAP_RS01555	COG1523	belongs to the glycosyl hydrolase 13 family
SPAP_RS01575	COG2176	DNA-directed DNA polymerase activity
SPAP_RS01595	COG2309	aminopeptidase activity
SPAP_RS01600	COG2261	transglycosylase associated protein
SPAP_RS01605	COG1187	pseudouridine synthase activity
SPAP_RS01615	COG3579	cysteine-type endopeptidase activity
SPAP_RS01620	COG3716	PTS system mannose fructose sorbose family IID component
SPAP_RS01625	COG3715	PTS system
SPAP_RS01635	COG1064	alcohol dehydrogenase
SPAP_RS01640	COG0561	phosphatase activity
SPAP_RS01645	COG2252	PERMEase
SPAP_RS01655	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SPAP_RS01660	COG0285	dihydrofolate synthase activity
SPAP_RS01670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPAP_RS01670	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SPAP_RS01680	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPAP_RS01705	COG0386	Belongs to the glutathione peroxidase family
SPAP_RS01710	COG5492	domain, Protein
SPAP_RS01735	COG1028	Short-chain dehydrogenase reductase Sdr
SPAP_RS01745	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SPAP_RS01750	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPAP_RS01755	COG3715	PTS system
SPAP_RS01760	COG3716	PTS system mannose fructose sorbose family IID component
SPAP_RS01775	COG1609	Transcriptional regulator
SPAP_RS01810	COG4839	cell division protein FtsL
SPAP_RS01815	COG0768	penicillin binding
SPAP_RS01840	COG0366	Alpha amylase catalytic
SPAP_RS01855	COG4464	protein tyrosine phosphatase activity
SPAP_RS01860	COG3944	biosynthesis protein
SPAP_RS01865	COG0489	protein tyrosine kinase activity
SPAP_RS01885	COG0438	transferase activity, transferring glycosyl groups
SPAP_RS01910	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SPAP_RS01920	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SPAP_RS01930	COG4166	transmembrane transport
SPAP_RS01935	COG0366	Alpha amylase catalytic
SPAP_RS01940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPAP_RS01965	COG0116	Belongs to the methyltransferase superfamily
SPAP_RS01975	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SPAP_RS01980	COG0745	RESPONSE REGULATOR receiver
SPAP_RS02030	COG4585	Histidine kinase
SPAP_RS02035	COG2197	response regulator
SPAP_RS02060	COG0582	viral genome integration into host DNA
SPAP_RS02075	COG0681	Belongs to the peptidase S26 family
SPAP_RS02100	COG1115	amino acid carrier protein
SPAP_RS02125	COG0527	aspartate kinase activity
SPAP_RS02130	COG1024	Enoyl-CoA hydratase
SPAP_RS02135	COG1846	Transcriptional regulator
SPAP_RS02145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPAP_RS02155	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPAP_RS02160	COG1028	Short-chain dehydrogenase reductase Sdr
SPAP_RS02165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPAP_RS02180	COG0439	Biotin carboxylase
SPAP_RS02185	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPAP_RS02220	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SPAP_RS02245	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SPAP_RS02255	COG1461	Dihydroxyacetone kinase
SPAP_RS02260	COG0028	Belongs to the TPP enzyme family
SPAP_RS02265	COG0440	acetolactate synthase activity
SPAP_RS02285	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SPAP_RS02300	COG0765	amino acid transport
SPAP_RS02330	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPAP_RS02335	COG1882	Formate acetyltransferase
SPAP_RS02365	COG1846	Transcriptional regulator
SPAP_RS02365	COG1940	carbohydrate kinase activity
SPAP_RS02370	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPAP_RS02380	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPAP_RS02385	COG2723	6-phospho-beta-galactosidase activity
SPAP_RS02390	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPAP_RS02390	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPAP_RS02395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPAP_RS02400	COG0569	domain protein
SPAP_RS02420	COG1122	ATPase activity
SPAP_RS02435	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPAP_RS02440	COG0671	phosphoesterase, PA-phosphatase related
SPAP_RS02450	COG1247	-acetyltransferase
SPAP_RS02465	COG0504	CTP synthase activity
SPAP_RS02470	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPAP_RS02490	COG0789	Transcriptional regulator
SPAP_RS02495	COG0174	glutamine synthetase
SPAP_RS02515	COG4974	Belongs to the 'phage' integrase family
SPAP_RS02565	COG0484	heat shock protein binding
SPAP_RS02575	COG0537	adenosine 5'-monophosphoramidase activity
SPAP_RS02580	COG1131	(ABC) transporter
SPAP_RS02605	COG3290	protein histidine kinase activity
SPAP_RS02615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPAP_RS02620	COG2274	protein secretion by the type I secretion system
SPAP_RS02680	COG1266	CAAX protease self-immunity
SPAP_RS02700	COG0195	Participates in both transcription termination and antitermination
SPAP_RS02705	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPAP_RS02760	COG0519	Catalyzes the synthesis of GMP from XMP
SPAP_RS02770	COG0525	valine-tRNA ligase activity
SPAP_RS02815	COG3711	transcriptional antiterminator
SPAP_RS02820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPAP_RS02820	COG2190	(PTS) system
SPAP_RS02820	COG1263	PTS System
SPAP_RS02835	COG0456	acetyltransferase
SPAP_RS02840	COG0072	phenylalanine-tRNA ligase activity
SPAP_RS02840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPAP_RS02860	COG3620	sequence-specific DNA binding
SPAP_RS02865	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SPAP_RS02875	COG1185	polyribonucleotide nucleotidyltransferase activity
SPAP_RS02880	COG1045	serine acetyltransferase
SPAP_RS02890	COG0215	cysteine-tRNA ligase activity
SPAP_RS02895	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPAP_RS02915	COG0577	efflux transmembrane transporter activity
SPAP_RS02920	COG1136	(ABC) transporter
SPAP_RS02925	COG0577	efflux transmembrane transporter activity
SPAP_RS02930	COG0745	RESPONSE REGULATOR receiver
SPAP_RS02935	COG5002	protein histidine kinase activity
SPAP_RS02940	COG0191	fructose-bisphosphate aldolase activity
SPAP_RS02945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SPAP_RS02950	COG0765	amino acid transport
SPAP_RS02955	COG0765	amino acid transport
SPAP_RS02960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPAP_RS02970	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPAP_RS02970	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPAP_RS03010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPAP_RS03025	COG1573	uracil-dna glycosylase
SPAP_RS03035	COG1114	Component of the transport system for branched-chain amino acids
SPAP_RS03040	COG1363	Peptidase, m42
SPAP_RS03090	COG4555	ABC transporter
SPAP_RS03135	COG3775	system Galactitol-specific IIC component
SPAP_RS03145	COG3250	beta-galactosidase activity
SPAP_RS03170	COG1242	4 iron, 4 sulfur cluster binding
SPAP_RS03175	COG1242	4 iron, 4 sulfur cluster binding
SPAP_RS03180	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPAP_RS03200	COG0785	Cytochrome C biogenesis protein
SPAP_RS03205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPAP_RS03210	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPAP_RS03210	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPAP_RS03215	COG4753	response regulator
SPAP_RS03215	COG2207	Transcriptional regulator
SPAP_RS03220	COG2972	Histidine kinase
SPAP_RS03225	COG4475	Protein of unknown function (DUF436)
SPAP_RS03230	COG3064	Membrane
SPAP_RS03235	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPAP_RS03250	COG1940	carbohydrate kinase activity
SPAP_RS03270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPAP_RS03275	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPAP_RS03285	COG0300	oxidoreductase activity
SPAP_RS03300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPAP_RS03310	COG1187	pseudouridine synthase activity
SPAP_RS03315	COG1217	gtp-binding protein TYPA
SPAP_RS03340	COG1136	(ABC) transporter
SPAP_RS03355	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SPAP_RS03365	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SPAP_RS03390	COG1131	(ABC) transporter
SPAP_RS03395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPAP_RS03410	COG0765	amino acid transport
SPAP_RS03420	COG1304	FMN binding
SPAP_RS03430	COG1304	FMN binding
SPAP_RS03450	COG0352	thiamine-phosphate diphosphorylase activity
SPAP_RS03460	COG4172	Belongs to the ABC transporter superfamily
SPAP_RS03470	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SPAP_RS03485	COG0352	thiamine-phosphate diphosphorylase activity
SPAP_RS03505	COG2217	Heavy metal translocating P-type atpase
SPAP_RS03510	COG0028	Belongs to the TPP enzyme family
SPAP_RS03525	COG3335	DDE superfamily endonuclease
SPAP_RS03535	COG2723	6-phospho-beta-galactosidase activity
SPAP_RS03540	COG1482	cell wall glycoprotein biosynthetic process
SPAP_RS03545	COG0733	neurotransmitter:sodium symporter activity
SPAP_RS03550	COG0789	Transcriptional regulator
SPAP_RS03560	COG2081	HI0933 family
SPAP_RS03565	COG1307	EDD domain protein, DegV family
SPAP_RS03575	COG2131	deaminase
SPAP_RS03580	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SPAP_RS03620	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPAP_RS03620	COG0517	IMP dehydrogenase activity
SPAP_RS03620	COG0617	tRNA 3'-terminal CCA addition
SPAP_RS03625	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SPAP_RS03630	COG2884	Cell division ATP-binding protein ftsE
SPAP_RS03635	COG2177	Part of the ABC transporter FtsEX involved in
SPAP_RS03640	COG1263	PTS System
SPAP_RS03640	COG2190	(PTS) system
SPAP_RS03640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPAP_RS03650	COG0513	Belongs to the DEAD box helicase family
SPAP_RS03660	COG0167	dihydroorotate dehydrogenase activity
SPAP_RS03670	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SPAP_RS03675	COG4470	Protein conserved in bacteria
SPAP_RS03690	COG0488	(ABC) transporter
SPAP_RS03725	COG1837	Belongs to the UPF0109 family
SPAP_RS03745	COG1328	CTP reductase activity
SPAP_RS03745	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPAP_RS03755	COG4443	Transcriptional Coactivator p15 (PC4)
SPAP_RS03765	COG1268	BioY protein
SPAP_RS03770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPAP_RS03775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPAP_RS03780	COG1136	(ABC) transporter
SPAP_RS03785	COG0577	efflux transmembrane transporter activity
SPAP_RS03790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPAP_RS03790	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPAP_RS03810	COG4989	oxidoreductase activity
SPAP_RS03820	COG1028	Short-chain dehydrogenase reductase Sdr
SPAP_RS03845	COG0745	RESPONSE REGULATOR receiver
SPAP_RS03850	COG5002	protein histidine kinase activity
SPAP_RS03870	COG0772	Belongs to the SEDS family
SPAP_RS03875	COG0693	protein deglycase activity
SPAP_RS03885	COG0187	DNA topoisomerase II activity
SPAP_RS03905	COG0494	nUDIX hydrolase
SPAP_RS03925	COG0542	response to heat
SPAP_RS03930	COG4703	Protein of unknown function (DUF1797)
SPAP_RS03935	COG0765	amino acid transport
SPAP_RS03940	COG1126	abc transporter atp-binding protein
SPAP_RS03945	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPAP_RS03950	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SPAP_RS03970	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SPAP_RS04015	COG2813	Specifically methylates the guanine in position
SPAP_RS04020	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SPAP_RS04030	COG0295	cytidine deaminase activity
SPAP_RS04035	COG1744	ABC transporter substrate-binding protein PnrA-like
SPAP_RS04040	COG3845	ABC transporter
SPAP_RS04045	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPAP_RS04050	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPAP_RS04065	COG2801	Transposase and inactivated derivatives
SPAP_RS04075	COG0187	DNA topoisomerase II activity
SPAP_RS04085	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPAP_RS04090	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPAP_RS04095	COG4166	transmembrane transport
SPAP_RS04130	COG0539	negative regulation of cytoplasmic translation
SPAP_RS04150	COG1956	GAF domain-containing protein
SPAP_RS04155	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPAP_RS04170	COG0719	Fe-S assembly protein
SPAP_RS04175	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPAP_RS04185	COG0719	Fe-S assembly protein
SPAP_RS04195	COG1686	Belongs to the peptidase S11 family
SPAP_RS04200	COG0628	permease
SPAP_RS04210	COG1349	DNA-binding transcription factor activity
SPAP_RS04215	COG1105	Belongs to the carbohydrate kinase PfkB family
SPAP_RS04220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPAP_RS04220	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPAP_RS04220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPAP_RS04225	COG1674	ftsk spoiiie
SPAP_RS04225	COG0697	spore germination
SPAP_RS04245	COG1136	(ABC) transporter
SPAP_RS04255	COG1104	cysteine desulfurase activity
SPAP_RS04300	COG1484	DNA-dependent DNA replication
SPAP_RS04405	COG0551	DNA topoisomerase type I activity
SPAP_RS04405	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPAP_RS04435	COG1309	transcriptional regulator
SPAP_RS04440	COG1131	(ABC) transporter
SPAP_RS04470	COG3843	relaxase mobilization nuclease domain protein
SPAP_RS04570	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
SPAP_RS04580	COG1438	arginine binding
SPAP_RS04600	COG0469	pyruvate kinase activity
SPAP_RS04605	COG0582	viral genome integration into host DNA
SPAP_RS04640	COG3689	TIGRFAM TIGR03943 family protein
SPAP_RS04645	COG0701	Predicted permease
SPAP_RS04655	COG2183	response to ionizing radiation
SPAP_RS04680	COG1136	(ABC) transporter
SPAP_RS04685	COG0577	efflux transmembrane transporter activity
SPAP_RS04700	COG1982	Orn Lys Arg decarboxylase major
SPAP_RS04715	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SPAP_RS04735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPAP_RS04740	COG0561	phosphatase activity
SPAP_RS04760	COG0583	DNA-binding transcription factor activity
SPAP_RS04765	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPAP_RS04770	COG0564	pseudouridine synthase activity
SPAP_RS04775	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPAP_RS04785	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SPAP_RS04790	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPAP_RS04800	COG0470	DNA polymerase III
SPAP_RS04850	COG0528	UMP kinase activity
SPAP_RS04860	COG2996	Protein conserved in bacteria
SPAP_RS04870	COG1702	phosphate starvation-inducible protein PhoH
SPAP_RS04885	COG0686	Belongs to the AlaDH PNT family
SPAP_RS04890	COG0686	Belongs to the AlaDH PNT family
SPAP_RS04895	COG0686	Belongs to the AlaDH PNT family
SPAP_RS04900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPAP_RS04905	COG1596	polysaccharide export
SPAP_RS04905	COG1555	photosystem II stabilization
SPAP_RS04910	COG2333	competence protein COMEC
SPAP_RS04910	COG0658	competence protein
SPAP_RS04915	COG1131	(ABC) transporter
SPAP_RS04945	COG0543	2 iron, 2 sulfur cluster binding
SPAP_RS04950	COG0167	dihydroorotate dehydrogenase activity
SPAP_RS04955	COG5263	repeat protein
SPAP_RS04955	COG4193	domain, Protein
SPAP_RS04960	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPAP_RS04970	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPAP_RS04980	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPAP_RS04985	COG0237	dephospho-CoA kinase activity
SPAP_RS04990	COG2814	Major facilitator Superfamily
SPAP_RS05005	COG0557	exoribonuclease II activity
SPAP_RS05015	COG0500	methyltransferase
SPAP_RS05015	COG3615	Tellurite resistance protein tehB
SPAP_RS05030	COG4122	O-methyltransferase activity
SPAP_RS05040	COG2801	Transposase and inactivated derivatives
SPAP_RS05055	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SPAP_RS05075	COG0494	nUDIX hydrolase
SPAP_RS05085	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPAP_RS05095	COG2176	DNA-directed DNA polymerase activity
SPAP_RS05100	COG0584	glycerophosphoryl diester phosphodiesterase
SPAP_RS05120	COG0785	Cytochrome C biogenesis protein
SPAP_RS05125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPAP_RS05130	COG0531	amino acid
SPAP_RS05135	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPAP_RS05135	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPAP_RS05145	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SPAP_RS05150	COG1011	Hydrolase
SPAP_RS05165	COG1051	belongs to the nudix hydrolase family
SPAP_RS05170	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPAP_RS05180	COG0534	Mate efflux family protein
SPAP_RS05185	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPAP_RS05190	COG0022	dehydrogenase e1 component
SPAP_RS05195	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPAP_RS05200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPAP_RS05205	COG0095	Lipoate-protein ligase
SPAP_RS05225	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPAP_RS05230	COG3583	domain protein
SPAP_RS05230	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
SPAP_RS05265	COG0582	viral genome integration into host DNA
SPAP_RS05285	COG0560	Phosphoserine phosphatase
SPAP_RS05290	COG0560	Phosphoserine phosphatase
SPAP_RS05300	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SPAP_RS05310	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SPAP_RS05315	COG1012	belongs to the aldehyde dehydrogenase family
SPAP_RS05325	COG1523	belongs to the glycosyl hydrolase 13 family
SPAP_RS05345	COG0488	(ABC) transporter
SPAP_RS05355	COG1307	EDD domain protein, DegV family
SPAP_RS05360	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPAP_RS05365	COG0196	riboflavin kinase activity
SPAP_RS05420	COG0280	phosphate acetyltransferase
SPAP_RS05425	COG0564	pseudouridine synthase activity
SPAP_RS05435	COG2357	RelA SpoT domain protein
SPAP_RS05445	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPAP_RS05450	COG1104	cysteine desulfurase activity
SPAP_RS05470	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPAP_RS05480	COG0210	DNA helicase
SPAP_RS05495	COG0024	Methionine aminopeptidase
SPAP_RS05500	COG4109	DRTGG domain
SPAP_RS05510	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPAP_RS05535	COG0438	transferase activity, transferring glycosyl groups
SPAP_RS05540	COG0438	transferase activity, transferring glycosyl groups
SPAP_RS05545	COG2151	metal-sulfur cluster biosynthetic enzyme
SPAP_RS05550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPAP_RS05555	COG0358	DNA primase activity
SPAP_RS05570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPAP_RS05585	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SPAP_RS05590	COG0772	Belongs to the SEDS family
SPAP_RS05605	COG1396	sequence-specific DNA binding
SPAP_RS05640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPAP_RS05685	COG0366	Alpha amylase catalytic
SPAP_RS05690	COG1597	lipid kinase activity
SPAP_RS05760	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPAP_RS05765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPAP_RS05790	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPAP_RS05800	COG0741	lytic transglycosylase activity
SPAP_RS05825	COG2890	protein-(glutamine-N5) methyltransferase activity
SPAP_RS05840	COG1435	thymidine kinase activity
SPAP_RS05845	COG1942	4-Oxalocrotonate Tautomerase
SPAP_RS05850	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SPAP_RS05860	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPAP_RS05870	COG4708	membrane
SPAP_RS05880	COG1970	mechanosensitive ion channel activity
SPAP_RS05885	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SPAP_RS05895	COG4509	Sortase family
SPAP_RS05905	COG0681	Belongs to the peptidase S26 family
SPAP_RS05925	COG2195	Cleaves the N-terminal amino acid of tripeptides
SPAP_RS05965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPAP_RS05970	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPAP_RS05975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPAP_RS05980	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPAP_RS05995	COG2723	6-phospho-beta-galactosidase activity
SPAP_RS06010	COG3711	transcriptional antiterminator
SPAP_RS06015	COG3684	Belongs to the aldolase LacD family
SPAP_RS06070	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SPAP_RS06075	COG0497	DNA recombination
SPAP_RS06080	COG1438	arginine binding
SPAP_RS06085	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPAP_RS06120	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SPAP_RS06150	COG3764	Sortase (surface protein transpeptidase)
SPAP_RS06155	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPAP_RS06165	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SPAP_RS06180	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPAP_RS06185	COG5002	protein histidine kinase activity
SPAP_RS06190	COG0745	RESPONSE REGULATOR receiver
SPAP_RS06195	COG1194	a g-specific adenine glycosylase
SPAP_RS06210	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPAP_RS06215	COG4684	Psort location CytoplasmicMembrane, score
SPAP_RS06225	COG1827	regulation of RNA biosynthetic process
SPAP_RS06230	COG2816	NAD+ diphosphatase activity
SPAP_RS06255	COG0765	amino acid transport
SPAP_RS06260	COG1126	abc transporter atp-binding protein
SPAP_RS06265	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPAP_RS06270	COG0552	protein localization to endoplasmic reticulum
SPAP_RS06275	COG0561	phosphatase activity
SPAP_RS06280	COG0561	phosphatase activity
SPAP_RS06285	COG1196	nuclear chromosome segregation
SPAP_RS06310	COG1401	restriction endodeoxyribonuclease activity
SPAP_RS06325	COG0066	3-isopropylmalate dehydratase activity
SPAP_RS06335	COG0473	3-isopropylmalate dehydrogenase activity
SPAP_RS06355	COG3142	Participates in the control of copper homeostasis
SPAP_RS06365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPAP_RS06385	COG0758	DNA mediated transformation
SPAP_RS06390	COG4750	Nucleotidyl transferase
SPAP_RS06405	COG1063	alcohol dehydrogenase
SPAP_RS06410	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SPAP_RS06420	COG3475	LICD family
SPAP_RS06425	COG3475	LICD family
SPAP_RS06435	COG0505	Belongs to the CarA family
SPAP_RS06450	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPAP_RS06465	COG0488	(ABC) transporter
SPAP_RS06470	COG0501	Belongs to the peptidase M48B family
SPAP_RS06475	COG1704	LemA family
SPAP_RS06490	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPAP_RS06505	COG1078	dGTPase activity
SPAP_RS06530	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPAP_RS06535	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPAP_RS06540	COG1605	Chorismate mutase
SPAP_RS06540	COG0077	Prephenate dehydratase
SPAP_RS06545	COG0716	FMN binding
SPAP_RS06550	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPAP_RS06570	COG3335	DDE superfamily endonuclease
SPAP_RS06580	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPAP_RS06680	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPAP_RS06685	COG1269	ATP hydrolysis coupled proton transport
SPAP_RS06700	COG0673	inositol 2-dehydrogenase activity
SPAP_RS06705	COG4409	exo-alpha-(2->6)-sialidase activity
SPAP_RS06715	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPAP_RS06720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPAP_RS06725	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SPAP_RS06730	COG1737	Transcriptional regulator
SPAP_RS06770	COG1136	(ABC) transporter
SPAP_RS06770	COG0577	efflux transmembrane transporter activity
SPAP_RS06780	COG1770	oligopeptidase
SPAP_RS06785	COG0515	serine threonine protein kinase
SPAP_RS06820	COG0402	S-adenosylhomocysteine deaminase activity
SPAP_RS06830	COG1132	(ABC) transporter
SPAP_RS06835	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPAP_RS06835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPAP_RS06870	COG1215	transferase activity, transferring glycosyl groups
SPAP_RS06880	COG3475	LICD family
SPAP_RS06890	COG0077	Prephenate dehydratase
SPAP_RS06895	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SPAP_RS06910	COG0287	Prephenate dehydrogenase
SPAP_RS06935	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPAP_RS06945	COG1131	(ABC) transporter
SPAP_RS06990	COG3842	ATPase activity
SPAP_RS07005	COG3527	Alpha-acetolactate decarboxylase
SPAP_RS07010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPAP_RS07015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPAP_RS07020	COG0704	Plays a role in the regulation of phosphate uptake
SPAP_RS07025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPAP_RS07030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPAP_RS07035	COG0581	inorganic phosphate transmembrane transporter activity
SPAP_RS07040	COG0573	inorganic phosphate transmembrane transporter activity
SPAP_RS07045	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPAP_RS07050	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPAP_RS07050	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPAP_RS07055	COG0483	inositol monophosphate 1-phosphatase activity
SPAP_RS07065	COG1393	Belongs to the ArsC family
SPAP_RS07075	COG0647	UMP catabolic process
SPAP_RS07085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPAP_RS07120	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SPAP_RS07135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPAP_RS07145	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPAP_RS07165	COG1131	(ABC) transporter
SPAP_RS07170	COG0826	peptidase U32
SPAP_RS07175	COG0826	peptidase U32
SPAP_RS07200	COG1132	(ABC) transporter
SPAP_RS07205	COG1132	(ABC) transporter
SPAP_RS07220	COG1129	ABC transporter
SPAP_RS07260	COG2188	Transcriptional regulator
SPAP_RS07265	COG0697	spore germination
SPAP_RS07270	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPAP_RS07285	COG0561	phosphatase activity
SPAP_RS07315	COG0492	ferredoxin-NADP+ reductase activity
SPAP_RS07325	COG1126	abc transporter atp-binding protein
SPAP_RS07335	COG1393	Belongs to the ArsC family
SPAP_RS07355	COG1272	protein, Hemolysin III
SPAP_RS07385	COG0431	NADPH-dependent FMN reductase
SPAP_RS07385	COG1053	succinate dehydrogenase
SPAP_RS07385	COG3976	FMN-binding domain protein
SPAP_RS07410	COG0656	L-ascorbic acid biosynthetic process
SPAP_RS07415	COG0726	polysaccharide deacetylase
SPAP_RS07440	COG3335	DDE superfamily endonuclease
SPAP_RS07460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPAP_RS07495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPAP_RS07505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPAP_RS07510	COG1126	abc transporter atp-binding protein
SPAP_RS07525	COG0628	permease
SPAP_RS07530	COG2706	6-phosphogluconolactonase activity
SPAP_RS07590	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPAP_RS07615	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPAP_RS07620	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SPAP_RS07625	COG0626	cystathionine gamma-synthase activity
SPAP_RS07630	COG1132	(ABC) transporter
SPAP_RS07635	COG1132	(ABC) transporter
SPAP_RS07640	COG4166	transmembrane transport
SPAP_RS07645	COG2244	polysaccharide biosynthetic process
SPAP_RS07650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPAP_RS07675	COG2827	Endonuclease containing a URI domain
SPAP_RS07680	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPAP_RS07685	COG1098	S1 RNA binding domain
SPAP_RS07695	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPAP_RS07700	COG0629	single-stranded DNA binding
SPAP_RS07710	COG0017	Asparaginyl-tRNA synthetase
SPAP_RS07720	COG0436	Aminotransferase
SPAP_RS07755	COG0242	peptide deformylase activity
SPAP_RS07760	COG0625	glutathione transferase activity
SPAP_RS07770	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPAP_RS07775	COG0488	(ABC) transporter
SPAP_RS07780	COG0617	tRNA 3'-terminal CCA addition
SPAP_RS07790	COG1307	EDD domain protein, DegV family
SPAP_RS07810	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPAP_RS07825	COG1481	regulation of sporulation
SPAP_RS07830	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SPAP_RS07840	COG0251	oxidation-reduction process
SPAP_RS07860	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPAP_RS07870	COG5263	repeat protein
SPAP_RS07870	COG4193	domain, Protein
SPAP_RS07880	COG3935	DnaD domain protein
SPAP_RS07895	COG2226	methyltransferase
SPAP_RS07905	COG3842	ATPase activity
SPAP_RS07915	COG1335	isochorismatase
SPAP_RS07930	COG0513	Belongs to the DEAD box helicase family
SPAP_RS07935	COG2223	nitrite transmembrane transporter activity
SPAP_RS07940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPAP_RS07945	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPAP_RS07950	COG3442	glutamine amidotransferase
SPAP_RS07955	COG0006	proline dipeptidase activity
SPAP_RS07975	COG4720	Psort location CytoplasmicMembrane, score
SPAP_RS07980	COG0351	phosphomethylpyrimidine kinase
SPAP_RS08005	COG2824	Alkylphosphonate utilization operon protein PhnA
SPAP_RS08025	COG0463	Glycosyl transferase, family 2
SPAP_RS08030	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPAP_RS08040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPAP_RS08045	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SPAP_RS08055	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SPAP_RS08060	COG0204	Acyl-transferase
SPAP_RS08075	COG2910	NAD(P)H-binding
SPAP_RS08095	COG5002	protein histidine kinase activity
SPAP_RS08100	COG0745	RESPONSE REGULATOR receiver
SPAP_RS08115	COG1959	2 iron, 2 sulfur cluster binding
SPAP_RS08170	COG3590	peptidase
SPAP_RS08185	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPAP_RS08190	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SPAP_RS08200	COG1136	(ABC) transporter
SPAP_RS08200	COG0577	efflux transmembrane transporter activity
SPAP_RS08230	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SPAP_RS08245	COG3599	regulation of cell shape
SPAP_RS08265	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPAP_RS08285	COG1051	belongs to the nudix hydrolase family
SPAP_RS08290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPAP_RS08305	COG0768	penicillin binding
SPAP_RS08320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPAP_RS08335	COG2731	YhcH YjgK YiaL family protein
SPAP_RS08340	COG0395	ABC-type sugar transport system, permease component
SPAP_RS08345	COG1175	transmembrane transport
SPAP_RS08355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPAP_RS08355	COG2190	(PTS) system
SPAP_RS08355	COG1263	PTS System
SPAP_RS08365	COG0673	inositol 2-dehydrogenase activity
SPAP_RS08370	COG4409	exo-alpha-(2->6)-sialidase activity
SPAP_RS08385	COG4409	exo-alpha-(2->6)-sialidase activity
SPAP_RS08395	COG1175	transmembrane transport
SPAP_RS08400	COG1653	transport
SPAP_RS08425	COG3458	cephalosporin-C deacetylase activity
SPAP_RS08430	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPAP_RS08445	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPAP_RS08450	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPAP_RS08455	COG0653	protein targeting
SPAP_RS08465	COG1131	(ABC) transporter
SPAP_RS08495	COG0778	Nitroreductase
SPAP_RS08500	COG1484	DNA-dependent DNA replication
SPAP_RS08515	COG1725	Transcriptional regulator
SPAP_RS08520	COG1131	(ABC) transporter
SPAP_RS08530	COG1668	transmembrane transport
SPAP_RS08535	COG4152	abc transporter atp-binding protein
SPAP_RS08555	COG1940	carbohydrate kinase activity
SPAP_RS08560	COG1263	PTS System
SPAP_RS08560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPAP_RS08560	COG2190	(PTS) system
SPAP_RS08570	COG1621	beta-fructofuranosidase activity
SPAP_RS08575	COG1609	Transcriptional regulator
SPAP_RS08585	COG3425	synthase
SPAP_RS08615	COG0515	serine threonine protein kinase
SPAP_RS08615	COG2815	serine threonine protein kinase
SPAP_RS08620	COG0631	protein serine/threonine phosphatase activity
SPAP_RS08625	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPAP_RS08625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPAP_RS08635	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPAP_RS08645	COG0194	GDP metabolic process
SPAP_RS08655	COG4115	mRNA cleavage
SPAP_RS08670	COG2226	methyltransferase
SPAP_RS08675	COG0799	negative regulation of ribosome biogenesis
SPAP_RS08685	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPAP_RS08690	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SPAP_RS08695	COG1534	Rna-binding protein
SPAP_RS08700	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPAP_RS08715	COG0668	transmembrane transport
SPAP_RS08740	COG3118	belongs to the thioredoxin family
SPAP_RS08745	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SPAP_RS08755	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPAP_RS08770	COG1131	(ABC) transporter
SPAP_RS08775	COG0640	Transcriptional regulator
SPAP_RS08780	COG1164	Oligoendopeptidase f
SPAP_RS08785	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPAP_RS08795	COG1051	belongs to the nudix hydrolase family
SPAP_RS08830	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPAP_RS08840	COG1621	beta-fructofuranosidase activity
SPAP_RS08845	COG1653	transport
SPAP_RS08850	COG0395	ABC-type sugar transport system, permease component
SPAP_RS08855	COG4209	transmembrane transport
SPAP_RS08865	COG3711	transcriptional antiterminator
SPAP_RS08890	COG3237	CsbD-like
SPAP_RS08910	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPAP_RS08925	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPAP_RS08930	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPAP_RS08940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPAP_RS08945	COG1940	carbohydrate kinase activity
SPAP_RS08945	COG1846	Transcriptional regulator
SPAP_RS08955	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SPAP_RS08995	COG0512	Glutamine amidotransferase of anthranilate synthase
SPAP_RS09000	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPAP_RS09025	COG1285	pathogenesis
SPAP_RS09030	COG1178	ABC-type Fe3 transport system permease component
SPAP_RS09050	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPAP_RS09055	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPAP_RS09060	COG0704	Plays a role in the regulation of phosphate uptake
SPAP_RS09075	COG5434	Belongs to the glycosyl hydrolase 28 family
SPAP_RS09090	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SPAP_RS09095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPAP_RS09100	COG1132	(ABC) transporter
SPAP_RS09105	COG1132	(ABC) transporter
SPAP_RS09125	COG0708	Exodeoxyribonuclease III
SPAP_RS09145	COG2233	PERMEase
SPAP_RS09175	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPAP_RS09180	COG1609	Transcriptional regulator
SPAP_RS09185	COG1063	alcohol dehydrogenase
SPAP_RS09190	COG0789	Transcriptional regulator
SPAP_RS09195	COG1230	cation diffusion facilitator family transporter
SPAP_RS09205	COG3201	nicotinamide mononucleotide transporter
SPAP_RS09210	COG1174	glycine betaine transport
SPAP_RS09235	COG1363	Peptidase, m42
SPAP_RS09240	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPAP_RS09250	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPAP_RS09255	COG4605	iron ion homeostasis
SPAP_RS09260	COG4604	ABC transporter, ATP-binding protein
SPAP_RS09265	COG4607	ABC-type enterochelin transport system periplasmic component
SPAP_RS09275	COG1187	pseudouridine synthase activity
SPAP_RS09295	COG0517	IMP dehydrogenase activity
SPAP_RS09305	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SPAP_RS09325	COG0366	Alpha amylase catalytic
SPAP_RS09330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPAP_RS09330	COG1263	PTS System
SPAP_RS09335	COG2188	Transcriptional regulator
SPAP_RS09340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPAP_RS09355	COG4608	Belongs to the ABC transporter superfamily
SPAP_RS09360	COG0444	Belongs to the ABC transporter superfamily
SPAP_RS09365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPAP_RS09370	COG0601	transmembrane transport
SPAP_RS09375	COG4166	transmembrane transport
SPAP_RS09385	COG0366	Alpha amylase catalytic
SPAP_RS09390	COG0395	ABC-type sugar transport system, permease component
SPAP_RS09395	COG1175	transmembrane transport
SPAP_RS09400	COG1653	transport
SPAP_RS09405	COG3345	alpha-galactosidase
SPAP_RS09410	COG2207	Transcriptional regulator
SPAP_RS09415	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPAP_RS09415	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPAP_RS09510	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPAP_RS09515	COG2137	regulation of response to DNA damage stimulus
SPAP_RS09560	COG4221	oxidoreductase activity
SPAP_RS09565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPAP_RS09570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPAP_RS09605	COG1132	(ABC) transporter
SPAP_RS09690	COG5263	repeat protein
SPAP_RS09690	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPAP_RS09710	COG1316	TRANSCRIPTIONal
SPAP_RS09720	COG0802	atpase or kinase
SPAP_RS09740	COG0577	efflux transmembrane transporter activity
SPAP_RS09740	COG1136	(ABC) transporter
SPAP_RS09770	COG1253	flavin adenine dinucleotide binding
SPAP_RS09785	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPAP_RS09795	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPAP_RS09805	COG0742	ribosomal rna small subunit methyltransferase
SPAP_RS09820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPAP_RS09825	COG1254	Belongs to the acylphosphatase family
SPAP_RS09835	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPAP_RS09845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPAP_RS09860	COG1564	THIamine pyrophosphokinase
SPAP_RS09870	COG1162	GTPase activity
SPAP_RS09915	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SPAP_RS09920	COG0084	hydrolase, TatD family'
SPAP_RS09935	COG0436	Aminotransferase
SPAP_RS09945	COG0589	response to stress
SPAP_RS09950	COG0561	phosphatase activity
SPAP_RS09955	COG0252	asparaginase activity
SPAP_RS09965	COG1609	Transcriptional regulator
SPAP_RS09970	COG2197	response regulator
SPAP_RS09975	COG4585	Histidine kinase
SPAP_RS09980	COG0842	Transport permease protein
SPAP_RS09985	COG1131	(ABC) transporter
SPAP_RS10090	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPAP_RS10095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPAP_RS10110	COG0577	efflux transmembrane transporter activity
SPAP_RS10125	COG0157	Belongs to the NadC ModD family
SPAP_RS10135	COG4133	protoheme IX ABC transporter activity
SPAP_RS10140	COG2188	Transcriptional regulator
SPAP_RS10145	COG2723	6-phospho-beta-galactosidase activity
SPAP_RS10150	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPAP_RS10160	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPAP_RS10165	COG1012	belongs to the aldehyde dehydrogenase family
SPAP_RS10165	COG1454	alcohol dehydrogenase
SPAP_RS10175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPAP_RS10185	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SPAP_RS10205	COG3623	hexulose-6-phosphate isomerase
SPAP_RS10210	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SPAP_RS10215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPAP_RS10225	COG3037	sugar-specific permease SgaT UlaA
SPAP_RS10235	COG1847	R3H domain protein
SPAP_RS10240	COG0706	membrane insertase activity
SPAP_RS10290	COG4537	Required for transformation and DNA binding
SPAP_RS10295	COG1459	type II secretion system
SPAP_RS10300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPAP_RS10310	COG1063	alcohol dehydrogenase
SPAP_RS10335	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SPAP_RS10340	COG3759	membrane
SPAP_RS10355	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SPAP_RS10355	COG0131	Imidazoleglycerol-phosphate dehydratase
SPAP_RS10360	COG0534	Mate efflux family protein
SPAP_RS10475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SPAP_RS10490	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPAP_RS10495	COG1132	(ABC) transporter
SPAP_RS10505	COG1132	(ABC) transporter
SPAP_RS10515	COG1438	arginine binding
SPAP_RS10540	COG5002	protein histidine kinase activity
SPAP_RS10545	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPAP_RS10550	COG0573	inorganic phosphate transmembrane transporter activity
SPAP_RS10560	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPAP_RS10565	COG0704	Plays a role in the regulation of phosphate uptake
SPAP_RS10585	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPAP_RS10595	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPAP_RS10610	COG0697	spore germination
SPAP_RS10615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPAP_RS10625	COG2217	Heavy metal translocating P-type atpase
SPAP_RS10635	COG2226	methyltransferase
SPAP_RS10655	COG0058	SHG alpha-glucan phosphorylase activity
SPAP_RS10660	COG1640	4-alpha-glucanotransferase
SPAP_RS10665	COG2182	Extracellular solute-binding protein
SPAP_RS10675	COG3833	ABC-type maltose transport systems, permease component
SPAP_RS10680	COG5521	maltodextrose utilization protein MalA
SPAP_RS10685	COG1609	Transcriptional regulator
SPAP_RS10690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPAP_RS10725	COG1476	TRANSCRIPTIONal
SPAP_RS10755	COG2151	metal-sulfur cluster biosynthetic enzyme
SPAP_RS10770	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPAP_RS10775	COG3959	Transketolase, thiamine diphosphate binding domain
SPAP_RS10790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPAP_RS10810	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPAP_RS10850	COG0383	alpha-mannosidase activity
SPAP_RS10860	COG3537	Alpha-1,2-mannosidase
SPAP_RS10880	COG0549	Belongs to the carbamate kinase family
SPAP_RS10885	COG1288	antiporter activity
SPAP_RS10890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPAP_RS10900	COG3064	Membrane
SPAP_RS10900	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPAP_RS10900	COG3583	domain protein
SPAP_RS10910	COG1454	alcohol dehydrogenase
SPAP_RS10930	COG3716	PTS system mannose fructose sorbose family IID component
SPAP_RS10940	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPAP_RS10960	COG1070	Carbohydrate kinase
SPAP_RS10970	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPAP_RS10970	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPAP_RS10975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPAP_RS10980	COG1121	(ABC) transporter
SPAP_RS10985	COG1846	Transcriptional regulator
SPAP_RS11000	COG1696	Membrane protein involved in D-alanine export
SPAP_RS11015	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPAP_RS11020	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SPAP_RS11040	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPAP_RS11050	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPAP_RS11055	COG5002	protein histidine kinase activity
SPAP_RS11060	COG0745	RESPONSE REGULATOR receiver
SPAP_RS11065	COG0542	response to heat
SPAP_RS11070	COG4463	regulation of RNA biosynthetic process
SPAP_RS11075	COG1116	anion transmembrane transporter activity
SPAP_RS11080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SPAP_RS11085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SPAP_RS11105	COG0305	Participates in initiation and elongation during chromosome replication
SPAP_RS11125	COG1040	competence protein
SPAP_RS11130	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPAP_RS11135	COG1739	Uncharacterized protein family UPF0029
SPAP_RS11175	COG3942	CHAP domain
SPAP_RS11185	COG1792	Involved in formation and maintenance of cell shape
SPAP_RS11190	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPAP_RS11195	COG1122	ATPase activity
SPAP_RS11200	COG1122	ATPase activity
SPAP_RS11205	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPAP_RS11215	COG0612	Peptidase, M16
SPAP_RS11220	COG0612	Peptidase, M16
SPAP_RS11225	COG2501	S4 domain
SPAP_RS11235	COG0516	GMP reductase activity
SPAP_RS11235	COG0517	IMP dehydrogenase activity
SPAP_RS11240	COG0180	Tryptophanyl-tRNA synthetase
SPAP_RS11245	COG0488	(ABC) transporter
SPAP_RS11255	COG1511	domain protein
SPAP_RS11265	COG1511	domain protein
SPAP_RS11320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPAP_RS11325	COG1475	DNA binding
SPAP_RS11435	COG2801	Transposase and inactivated derivatives
SPAP_RS11445	COG3335	DDE superfamily endonuclease