locus-tag	class	description
SPN23F_RS00010	COG0592	DNA-directed DNA polymerase activity
SPN23F_RS00020	COG0012	GTP binding
SPN23F_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPN23F_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPN23F_RS00060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SPN23F_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPN23F_RS00120	COG3335	DDE superfamily endonuclease
SPN23F_RS00155	COG0582	viral genome integration into host DNA
SPN23F_RS00160	COG0582	viral genome integration into host DNA
SPN23F_RS00200	COG5263	repeat protein
SPN23F_RS00200	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPN23F_RS00210	COG0756	dUTP diphosphatase activity
SPN23F_RS00220	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SPN23F_RS00240	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPN23F_RS00260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPN23F_RS00260	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPN23F_RS00265	COG1832	CoA-binding protein
SPN23F_RS00275	COG2855	membrane
SPN23F_RS00280	COG0436	Aminotransferase
SPN23F_RS00295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPN23F_RS00315	COG2274	protein secretion by the type I secretion system
SPN23F_RS00320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPN23F_RS00330	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPN23F_RS00335	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SPN23F_RS00345	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPN23F_RS00360	COG0151	Belongs to the GarS family
SPN23F_RS00365	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPN23F_RS00380	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPN23F_RS00385	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPN23F_RS00385	COG3583	domain protein
SPN23F_RS00385	COG3064	Membrane
SPN23F_RS00400	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN23F_RS00405	COG3715	PTS system
SPN23F_RS00410	COG3716	PTS system mannose fructose sorbose family IID component
SPN23F_RS00420	COG2222	sugar isomerase
SPN23F_RS00430	COG2514	catechol 2,3-dioxygenase activity
SPN23F_RS00435	COG1937	Protein conserved in bacteria
SPN23F_RS00460	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPN23F_RS00465	COG0569	domain protein
SPN23F_RS00475	COG1215	transferase activity, transferring glycosyl groups
SPN23F_RS00495	COG5002	protein histidine kinase activity
SPN23F_RS00520	COG4209	transmembrane transport
SPN23F_RS00525	COG0395	ABC-type sugar transport system, permease component
SPN23F_RS00530	COG1653	transport
SPN23F_RS00560	COG1695	Transcriptional regulator
SPN23F_RS00590	COG0546	phosphoglycolate phosphatase activity
SPN23F_RS00595	COG1760	l-serine dehydratase
SPN23F_RS00600	COG1760	l-serine dehydratase
SPN23F_RS00630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN23F_RS00690	COG0494	nUDIX hydrolase
SPN23F_RS00695	COG0445	tRNA wobble uridine modification
SPN23F_RS00725	COG1214	PFAM Peptidase M22, glycoprotease
SPN23F_RS00765	COG0438	transferase activity, transferring glycosyl groups
SPN23F_RS00800	COG1396	sequence-specific DNA binding
SPN23F_RS00835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN23F_RS00840	COG1464	Belongs to the NlpA lipoprotein family
SPN23F_RS00845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPN23F_RS00850	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPN23F_RS00870	COG2972	Histidine kinase
SPN23F_RS00875	COG2207	Transcriptional regulator
SPN23F_RS00875	COG4753	response regulator
SPN23F_RS00885	COG1780	Probably involved in ribonucleotide reductase function
SPN23F_RS00915	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPN23F_RS00915	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPN23F_RS00935	COG2818	Glycosylase
SPN23F_RS00960	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPN23F_RS00965	COG0006	proline dipeptidase activity
SPN23F_RS00970	COG1393	Belongs to the ArsC family
SPN23F_RS00995	COG0285	dihydrofolate synthase activity
SPN23F_RS01005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPN23F_RS01070	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPN23F_RS01095	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SPN23F_RS01135	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SPN23F_RS01150	COG0201	protein transport
SPN23F_RS01160	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SPN23F_RS01165	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SPN23F_RS01175	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SPN23F_RS01180	COG0202	RNA polymerase activity
SPN23F_RS01190	COG3830	Belongs to the UPF0237 family
SPN23F_RS01210	COG1178	ABC-type Fe3 transport system permease component
SPN23F_RS01215	COG3842	ATPase activity
SPN23F_RS01235	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPN23F_RS01240	COG1349	DNA-binding transcription factor activity
SPN23F_RS01250	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPN23F_RS01255	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN23F_RS01260	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN23F_RS01265	COG1882	Formate acetyltransferase
SPN23F_RS01310	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPN23F_RS01315	COG4589	Belongs to the CDS family
SPN23F_RS01320	COG0750	zinc metalloprotease
SPN23F_RS01330	COG2723	6-phospho-beta-galactosidase activity
SPN23F_RS01335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPN23F_RS01345	COG1523	belongs to the glycosyl hydrolase 13 family
SPN23F_RS01365	COG2176	DNA-directed DNA polymerase activity
SPN23F_RS01390	COG2309	aminopeptidase activity
SPN23F_RS01395	COG2261	transglycosylase associated protein
SPN23F_RS01400	COG1187	pseudouridine synthase activity
SPN23F_RS01410	COG3579	cysteine-type endopeptidase activity
SPN23F_RS01415	COG3716	PTS system mannose fructose sorbose family IID component
SPN23F_RS01420	COG3715	PTS system
SPN23F_RS01430	COG1064	alcohol dehydrogenase
SPN23F_RS01435	COG0561	phosphatase activity
SPN23F_RS01440	COG2252	PERMEase
SPN23F_RS01450	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SPN23F_RS01455	COG0285	dihydrofolate synthase activity
SPN23F_RS01465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPN23F_RS01465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SPN23F_RS01475	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPN23F_RS01500	COG0386	Belongs to the glutathione peroxidase family
SPN23F_RS01505	COG5492	domain, Protein
SPN23F_RS01530	COG1028	Short-chain dehydrogenase reductase Sdr
SPN23F_RS01540	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SPN23F_RS01545	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN23F_RS01550	COG3715	PTS system
SPN23F_RS01555	COG3716	PTS system mannose fructose sorbose family IID component
SPN23F_RS01570	COG1609	Transcriptional regulator
SPN23F_RS01595	COG4839	cell division protein FtsL
SPN23F_RS01600	COG0768	penicillin binding
SPN23F_RS01630	COG0366	Alpha amylase catalytic
SPN23F_RS01635	COG4166	transmembrane transport
SPN23F_RS01650	COG4464	protein tyrosine phosphatase activity
SPN23F_RS01655	COG3944	biosynthesis protein
SPN23F_RS01660	COG0489	protein tyrosine kinase activity
SPN23F_RS01680	COG1442	glycosyl transferase family 8
SPN23F_RS01680	COG1216	Glycosyl transferase, family 2
SPN23F_RS01700	COG0371	Dehydrogenase
SPN23F_RS01705	COG1213	nucleotidyl transferase
SPN23F_RS01710	COG0647	UMP catabolic process
SPN23F_RS01715	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SPN23F_RS01725	COG1088	dTDP-glucose 4,6-dehydratase activity
SPN23F_RS01730	COG1091	dTDP-4-dehydrorhamnose reductase activity
SPN23F_RS01740	COG4372	Transposase
SPN23F_RS01745	COG4166	transmembrane transport
SPN23F_RS01750	COG0366	Alpha amylase catalytic
SPN23F_RS01755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPN23F_RS01780	COG0116	Belongs to the methyltransferase superfamily
SPN23F_RS01790	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SPN23F_RS01795	COG0745	RESPONSE REGULATOR receiver
SPN23F_RS01845	COG4585	Histidine kinase
SPN23F_RS01850	COG2197	response regulator
SPN23F_RS01900	COG2213	PTS system mannitol-specific
SPN23F_RS01905	COG3711	transcriptional antiterminator
SPN23F_RS01910	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPN23F_RS01935	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPN23F_RS01940	COG0681	Belongs to the peptidase S26 family
SPN23F_RS01965	COG1115	amino acid carrier protein
SPN23F_RS01990	COG0527	aspartate kinase activity
SPN23F_RS01995	COG1024	Enoyl-CoA hydratase
SPN23F_RS02000	COG1846	Transcriptional regulator
SPN23F_RS02010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPN23F_RS02020	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPN23F_RS02025	COG1028	Short-chain dehydrogenase reductase Sdr
SPN23F_RS02030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPN23F_RS02045	COG0439	Biotin carboxylase
SPN23F_RS02050	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPN23F_RS02110	COG1442	glycosyl transferase family 8
SPN23F_RS02115	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SPN23F_RS02125	COG1461	Dihydroxyacetone kinase
SPN23F_RS02130	COG0028	Belongs to the TPP enzyme family
SPN23F_RS02135	COG0440	acetolactate synthase activity
SPN23F_RS02155	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SPN23F_RS02170	COG0765	amino acid transport
SPN23F_RS02195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPN23F_RS02200	COG1882	Formate acetyltransferase
SPN23F_RS02240	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPN23F_RS02245	COG0569	domain protein
SPN23F_RS02265	COG1122	ATPase activity
SPN23F_RS02280	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPN23F_RS02285	COG0671	phosphoesterase, PA-phosphatase related
SPN23F_RS02295	COG1247	-acetyltransferase
SPN23F_RS02305	COG0504	CTP synthase activity
SPN23F_RS02310	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPN23F_RS02330	COG0789	Transcriptional regulator
SPN23F_RS02335	COG0174	glutamine synthetase
SPN23F_RS02345	COG0732	type I restriction modification DNA specificity domain
SPN23F_RS02355	COG4974	Belongs to the 'phage' integrase family
SPN23F_RS02405	COG0484	heat shock protein binding
SPN23F_RS02420	COG0537	adenosine 5'-monophosphoramidase activity
SPN23F_RS02425	COG1131	(ABC) transporter
SPN23F_RS02450	COG3290	protein histidine kinase activity
SPN23F_RS02460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPN23F_RS02465	COG2274	protein secretion by the type I secretion system
SPN23F_RS02470	COG2274	protein secretion by the type I secretion system
SPN23F_RS02535	COG1266	CAAX protease self-immunity
SPN23F_RS02555	COG0195	Participates in both transcription termination and antitermination
SPN23F_RS02560	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPN23F_RS02615	COG0519	Catalyzes the synthesis of GMP from XMP
SPN23F_RS02625	COG0525	valine-tRNA ligase activity
SPN23F_RS02665	COG3711	transcriptional antiterminator
SPN23F_RS02670	COG2190	(PTS) system
SPN23F_RS02670	COG1263	PTS System
SPN23F_RS02670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN23F_RS02685	COG0456	acetyltransferase
SPN23F_RS02690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPN23F_RS02690	COG0072	phenylalanine-tRNA ligase activity
SPN23F_RS02705	COG3620	sequence-specific DNA binding
SPN23F_RS02710	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SPN23F_RS02725	COG1045	serine acetyltransferase
SPN23F_RS02735	COG0215	cysteine-tRNA ligase activity
SPN23F_RS02740	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPN23F_RS02765	COG0577	efflux transmembrane transporter activity
SPN23F_RS02770	COG1136	(ABC) transporter
SPN23F_RS02775	COG0577	efflux transmembrane transporter activity
SPN23F_RS02780	COG0745	RESPONSE REGULATOR receiver
SPN23F_RS02785	COG5002	protein histidine kinase activity
SPN23F_RS02790	COG0191	fructose-bisphosphate aldolase activity
SPN23F_RS02795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SPN23F_RS02800	COG0765	amino acid transport
SPN23F_RS02805	COG0765	amino acid transport
SPN23F_RS02810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN23F_RS02820	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPN23F_RS02820	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPN23F_RS02860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN23F_RS02875	COG1573	uracil-dna glycosylase
SPN23F_RS02890	COG1114	Component of the transport system for branched-chain amino acids
SPN23F_RS02895	COG1363	Peptidase, m42
SPN23F_RS02935	COG4555	ABC transporter
SPN23F_RS02965	COG1404	Belongs to the peptidase S8 family
SPN23F_RS02980	COG3775	system Galactitol-specific IIC component
SPN23F_RS02985	COG3250	beta-galactosidase activity
SPN23F_RS03005	COG1242	4 iron, 4 sulfur cluster binding
SPN23F_RS03010	COG1242	4 iron, 4 sulfur cluster binding
SPN23F_RS03015	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPN23F_RS03035	COG0785	Cytochrome C biogenesis protein
SPN23F_RS03040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPN23F_RS03045	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPN23F_RS03045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPN23F_RS03050	COG4753	response regulator
SPN23F_RS03050	COG2207	Transcriptional regulator
SPN23F_RS03055	COG2972	Histidine kinase
SPN23F_RS03065	COG3064	Membrane
SPN23F_RS03070	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPN23F_RS03080	COG4193	domain, Protein
SPN23F_RS03080	COG5263	repeat protein
SPN23F_RS03085	COG1940	carbohydrate kinase activity
SPN23F_RS03105	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPN23F_RS03110	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPN23F_RS03120	COG0300	oxidoreductase activity
SPN23F_RS03135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPN23F_RS03145	COG1187	pseudouridine synthase activity
SPN23F_RS03150	COG1217	gtp-binding protein TYPA
SPN23F_RS03170	COG1136	(ABC) transporter
SPN23F_RS03185	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SPN23F_RS03195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SPN23F_RS03220	COG1131	(ABC) transporter
SPN23F_RS03225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN23F_RS03235	COG1126	abc transporter atp-binding protein
SPN23F_RS03240	COG0765	amino acid transport
SPN23F_RS03245	COG0765	amino acid transport
SPN23F_RS03250	COG1304	FMN binding
SPN23F_RS03260	COG1304	FMN binding
SPN23F_RS03280	COG0352	thiamine-phosphate diphosphorylase activity
SPN23F_RS03290	COG4172	Belongs to the ABC transporter superfamily
SPN23F_RS03300	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SPN23F_RS03315	COG0352	thiamine-phosphate diphosphorylase activity
SPN23F_RS03335	COG2217	Heavy metal translocating P-type atpase
SPN23F_RS03340	COG0028	Belongs to the TPP enzyme family
SPN23F_RS03355	COG3335	DDE superfamily endonuclease
SPN23F_RS03365	COG2723	6-phospho-beta-galactosidase activity
SPN23F_RS03370	COG1482	cell wall glycoprotein biosynthetic process
SPN23F_RS03375	COG0733	neurotransmitter:sodium symporter activity
SPN23F_RS03385	COG0789	Transcriptional regulator
SPN23F_RS03395	COG2081	HI0933 family
SPN23F_RS03400	COG1307	EDD domain protein, DegV family
SPN23F_RS03410	COG2131	deaminase
SPN23F_RS03415	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SPN23F_RS03455	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPN23F_RS03455	COG0517	IMP dehydrogenase activity
SPN23F_RS03455	COG0617	tRNA 3'-terminal CCA addition
SPN23F_RS03460	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SPN23F_RS03465	COG2884	Cell division ATP-binding protein ftsE
SPN23F_RS03470	COG2177	Part of the ABC transporter FtsEX involved in
SPN23F_RS03475	COG1263	PTS System
SPN23F_RS03475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN23F_RS03475	COG2190	(PTS) system
SPN23F_RS03485	COG0513	Belongs to the DEAD box helicase family
SPN23F_RS03495	COG0167	dihydroorotate dehydrogenase activity
SPN23F_RS03505	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SPN23F_RS03510	COG4470	Protein conserved in bacteria
SPN23F_RS03515	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SPN23F_RS03525	COG0488	(ABC) transporter
SPN23F_RS03555	COG1837	Belongs to the UPF0109 family
SPN23F_RS03575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPN23F_RS03575	COG1328	CTP reductase activity
SPN23F_RS03585	COG4443	Transcriptional Coactivator p15 (PC4)
SPN23F_RS03595	COG1268	BioY protein
SPN23F_RS03610	COG1136	(ABC) transporter
SPN23F_RS03610	COG0577	efflux transmembrane transporter activity
SPN23F_RS03620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPN23F_RS03625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPN23F_RS03630	COG1136	(ABC) transporter
SPN23F_RS03635	COG0577	efflux transmembrane transporter activity
SPN23F_RS03640	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPN23F_RS03640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPN23F_RS03660	COG4989	oxidoreductase activity
SPN23F_RS03670	COG1028	Short-chain dehydrogenase reductase Sdr
SPN23F_RS03705	COG0745	RESPONSE REGULATOR receiver
SPN23F_RS03710	COG5002	protein histidine kinase activity
SPN23F_RS03730	COG0772	Belongs to the SEDS family
SPN23F_RS03735	COG0693	protein deglycase activity
SPN23F_RS03745	COG0187	DNA topoisomerase II activity
SPN23F_RS03765	COG0494	nUDIX hydrolase
SPN23F_RS03775	COG0542	response to heat
SPN23F_RS03780	COG4703	Protein of unknown function (DUF1797)
SPN23F_RS03785	COG0765	amino acid transport
SPN23F_RS03790	COG1126	abc transporter atp-binding protein
SPN23F_RS03795	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPN23F_RS03805	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SPN23F_RS03825	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SPN23F_RS03875	COG2813	Specifically methylates the guanine in position
SPN23F_RS03880	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SPN23F_RS03890	COG0295	cytidine deaminase activity
SPN23F_RS03895	COG1744	ABC transporter substrate-binding protein PnrA-like
SPN23F_RS03900	COG3845	ABC transporter
SPN23F_RS03905	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPN23F_RS03910	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPN23F_RS03925	COG2801	Transposase and inactivated derivatives
SPN23F_RS03935	COG0187	DNA topoisomerase II activity
SPN23F_RS03945	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPN23F_RS03950	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPN23F_RS03955	COG4166	transmembrane transport
SPN23F_RS03990	COG0539	negative regulation of cytoplasmic translation
SPN23F_RS04010	COG1956	GAF domain-containing protein
SPN23F_RS04015	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPN23F_RS04030	COG0719	Fe-S assembly protein
SPN23F_RS04035	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPN23F_RS04045	COG0719	Fe-S assembly protein
SPN23F_RS04055	COG1686	Belongs to the peptidase S11 family
SPN23F_RS04060	COG0628	permease
SPN23F_RS04070	COG1349	DNA-binding transcription factor activity
SPN23F_RS04075	COG1105	Belongs to the carbohydrate kinase PfkB family
SPN23F_RS04080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPN23F_RS04080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPN23F_RS04080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPN23F_RS04085	COG0697	spore germination
SPN23F_RS04085	COG1674	ftsk spoiiie
SPN23F_RS04095	COG1104	cysteine desulfurase activity
SPN23F_RS04155	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
SPN23F_RS04160	COG1438	arginine binding
SPN23F_RS04180	COG0469	pyruvate kinase activity
SPN23F_RS04215	COG3689	TIGRFAM TIGR03943 family protein
SPN23F_RS04220	COG0701	Predicted permease
SPN23F_RS04230	COG2183	response to ionizing radiation
SPN23F_RS04255	COG1136	(ABC) transporter
SPN23F_RS04260	COG0577	efflux transmembrane transporter activity
SPN23F_RS04275	COG1982	Orn Lys Arg decarboxylase major
SPN23F_RS04290	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SPN23F_RS04315	COG0561	phosphatase activity
SPN23F_RS04335	COG0583	DNA-binding transcription factor activity
SPN23F_RS04340	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPN23F_RS04345	COG0564	pseudouridine synthase activity
SPN23F_RS04350	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPN23F_RS04365	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPN23F_RS04375	COG0470	DNA polymerase III
SPN23F_RS04425	COG0528	UMP kinase activity
SPN23F_RS04435	COG2996	Protein conserved in bacteria
SPN23F_RS04445	COG1702	phosphate starvation-inducible protein PhoH
SPN23F_RS04460	COG0686	Belongs to the AlaDH PNT family
SPN23F_RS04465	COG0686	Belongs to the AlaDH PNT family
SPN23F_RS04470	COG0686	Belongs to the AlaDH PNT family
SPN23F_RS04475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPN23F_RS04480	COG1596	polysaccharide export
SPN23F_RS04480	COG1555	photosystem II stabilization
SPN23F_RS04485	COG0658	competence protein
SPN23F_RS04485	COG2333	competence protein COMEC
SPN23F_RS04495	COG1131	(ABC) transporter
SPN23F_RS04525	COG0543	2 iron, 2 sulfur cluster binding
SPN23F_RS04530	COG0167	dihydroorotate dehydrogenase activity
SPN23F_RS04535	COG4193	domain, Protein
SPN23F_RS04535	COG5263	repeat protein
SPN23F_RS04540	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPN23F_RS04550	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPN23F_RS04560	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPN23F_RS04565	COG0237	dephospho-CoA kinase activity
SPN23F_RS04570	COG2814	Major facilitator Superfamily
SPN23F_RS04585	COG0557	exoribonuclease II activity
SPN23F_RS04595	COG3615	Tellurite resistance protein tehB
SPN23F_RS04595	COG0500	methyltransferase
SPN23F_RS04610	COG4122	O-methyltransferase activity
SPN23F_RS04620	COG2801	Transposase and inactivated derivatives
SPN23F_RS04635	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SPN23F_RS04650	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SPN23F_RS04655	COG0494	nUDIX hydrolase
SPN23F_RS04665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPN23F_RS04675	COG2176	DNA-directed DNA polymerase activity
SPN23F_RS04680	COG0584	glycerophosphoryl diester phosphodiesterase
SPN23F_RS04705	COG0785	Cytochrome C biogenesis protein
SPN23F_RS04710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPN23F_RS04715	COG0531	amino acid
SPN23F_RS04720	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPN23F_RS04720	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPN23F_RS04760	COG1970	mechanosensitive ion channel activity
SPN23F_RS04770	COG4708	membrane
SPN23F_RS04780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPN23F_RS04790	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SPN23F_RS04795	COG1942	4-Oxalocrotonate Tautomerase
SPN23F_RS04800	COG1435	thymidine kinase activity
SPN23F_RS04810	COG2890	protein-(glutamine-N5) methyltransferase activity
SPN23F_RS04835	COG0741	lytic transglycosylase activity
SPN23F_RS04845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPN23F_RS04865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPN23F_RS04870	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPN23F_RS04925	COG1597	lipid kinase activity
SPN23F_RS04930	COG0366	Alpha amylase catalytic
SPN23F_RS04945	COG1396	sequence-specific DNA binding
SPN23F_RS04950	COG0542	response to heat
SPN23F_RS04955	COG0613	PHP domain protein
SPN23F_RS04960	COG1196	nuclear chromosome segregation
SPN23F_RS04975	COG3843	relaxase mobilization nuclease domain protein
SPN23F_RS05005	COG2274	protein secretion by the type I secretion system
SPN23F_RS05015	COG1131	(ABC) transporter
SPN23F_RS05035	COG0772	Belongs to the SEDS family
SPN23F_RS05040	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SPN23F_RS05055	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPN23F_RS05060	COG0358	DNA primase activity
SPN23F_RS05065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPN23F_RS05070	COG2151	metal-sulfur cluster biosynthetic enzyme
SPN23F_RS05075	COG0438	transferase activity, transferring glycosyl groups
SPN23F_RS05080	COG0438	transferase activity, transferring glycosyl groups
SPN23F_RS05105	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPN23F_RS05115	COG4109	DRTGG domain
SPN23F_RS05120	COG0024	Methionine aminopeptidase
SPN23F_RS05140	COG0210	DNA helicase
SPN23F_RS05150	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPN23F_RS05170	COG1104	cysteine desulfurase activity
SPN23F_RS05175	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPN23F_RS05185	COG2357	RelA SpoT domain protein
SPN23F_RS05195	COG0564	pseudouridine synthase activity
SPN23F_RS05200	COG0280	phosphate acetyltransferase
SPN23F_RS05250	COG0196	riboflavin kinase activity
SPN23F_RS05255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPN23F_RS05260	COG1307	EDD domain protein, DegV family
SPN23F_RS05270	COG0488	(ABC) transporter
SPN23F_RS05280	COG2814	Major facilitator Superfamily
SPN23F_RS05290	COG1523	belongs to the glycosyl hydrolase 13 family
SPN23F_RS05300	COG1012	belongs to the aldehyde dehydrogenase family
SPN23F_RS05305	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SPN23F_RS05315	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SPN23F_RS05325	COG0560	Phosphoserine phosphatase
SPN23F_RS05330	COG0560	Phosphoserine phosphatase
SPN23F_RS05350	COG0582	viral genome integration into host DNA
SPN23F_RS05375	COG3583	domain protein
SPN23F_RS05375	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
SPN23F_RS05380	COG3064	Membrane
SPN23F_RS05385	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPN23F_RS05405	COG0095	Lipoate-protein ligase
SPN23F_RS05410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPN23F_RS05415	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPN23F_RS05420	COG0022	dehydrogenase e1 component
SPN23F_RS05425	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPN23F_RS05430	COG0534	Mate efflux family protein
SPN23F_RS05440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPN23F_RS05445	COG1051	belongs to the nudix hydrolase family
SPN23F_RS05460	COG1011	Hydrolase
SPN23F_RS05465	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SPN23F_RS05480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPN23F_RS05485	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPN23F_RS05490	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPN23F_RS05495	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPN23F_RS05525	COG3711	transcriptional antiterminator
SPN23F_RS05530	COG3684	Belongs to the aldolase LacD family
SPN23F_RS05585	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SPN23F_RS05590	COG0497	DNA recombination
SPN23F_RS05595	COG1438	arginine binding
SPN23F_RS05600	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPN23F_RS05635	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SPN23F_RS05655	COG3764	Sortase (surface protein transpeptidase)
SPN23F_RS05660	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPN23F_RS05670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SPN23F_RS05685	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPN23F_RS05690	COG5002	protein histidine kinase activity
SPN23F_RS05695	COG0745	RESPONSE REGULATOR receiver
SPN23F_RS05700	COG1194	a g-specific adenine glycosylase
SPN23F_RS05715	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPN23F_RS05720	COG4684	Psort location CytoplasmicMembrane, score
SPN23F_RS05730	COG1827	regulation of RNA biosynthetic process
SPN23F_RS05760	COG0765	amino acid transport
SPN23F_RS05765	COG1126	abc transporter atp-binding protein
SPN23F_RS05770	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPN23F_RS05775	COG0552	protein localization to endoplasmic reticulum
SPN23F_RS05780	COG0561	phosphatase activity
SPN23F_RS05785	COG0561	phosphatase activity
SPN23F_RS05790	COG1196	nuclear chromosome segregation
SPN23F_RS05815	COG1401	restriction endodeoxyribonuclease activity
SPN23F_RS05830	COG0066	3-isopropylmalate dehydratase activity
SPN23F_RS05840	COG0473	3-isopropylmalate dehydrogenase activity
SPN23F_RS05860	COG3142	Participates in the control of copper homeostasis
SPN23F_RS05865	COG2832	Protein of unknown function (DUF454)
SPN23F_RS05870	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPN23F_RS05880	COG0758	DNA mediated transformation
SPN23F_RS05885	COG4750	Nucleotidyl transferase
SPN23F_RS05900	COG1063	alcohol dehydrogenase
SPN23F_RS05915	COG3475	LICD family
SPN23F_RS05920	COG3475	LICD family
SPN23F_RS05930	COG0505	Belongs to the CarA family
SPN23F_RS05945	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPN23F_RS05965	COG0488	(ABC) transporter
SPN23F_RS05975	COG1704	LemA family
SPN23F_RS05990	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPN23F_RS06005	COG1078	dGTPase activity
SPN23F_RS06025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPN23F_RS06030	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPN23F_RS06035	COG0077	Prephenate dehydratase
SPN23F_RS06035	COG1605	Chorismate mutase
SPN23F_RS06040	COG0716	FMN binding
SPN23F_RS06045	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPN23F_RS06065	COG3335	DDE superfamily endonuclease
SPN23F_RS06075	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPN23F_RS06160	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPN23F_RS06165	COG1269	ATP hydrolysis coupled proton transport
SPN23F_RS06180	COG0673	inositol 2-dehydrogenase activity
SPN23F_RS06185	COG4409	exo-alpha-(2->6)-sialidase activity
SPN23F_RS06195	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPN23F_RS06200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPN23F_RS06205	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SPN23F_RS06225	COG2801	Transposase and inactivated derivatives
SPN23F_RS06240	COG1136	(ABC) transporter
SPN23F_RS06240	COG0577	efflux transmembrane transporter activity
SPN23F_RS06250	COG1770	oligopeptidase
SPN23F_RS06255	COG0515	serine threonine protein kinase
SPN23F_RS06280	COG4974	Belongs to the 'phage' integrase family
SPN23F_RS06295	COG3843	relaxase mobilization nuclease domain protein
SPN23F_RS06315	COG0210	DNA helicase
SPN23F_RS06350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SPN23F_RS06390	COG0542	response to heat
SPN23F_RS06395	COG1396	sequence-specific DNA binding
SPN23F_RS06560	COG1674	ftsk spoiiie
SPN23F_RS06565	COG2946	Replication initiation factor
SPN23F_RS06595	COG0741	lytic transglycosylase activity
SPN23F_RS06595	COG0791	NLP P60 protein
SPN23F_RS06635	COG0582	viral genome integration into host DNA
SPN23F_RS06660	COG0270	DNA (cytosine-5-)-methyltransferase activity
SPN23F_RS06685	COG0402	S-adenosylhomocysteine deaminase activity
SPN23F_RS06695	COG1132	(ABC) transporter
SPN23F_RS06700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPN23F_RS06700	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPN23F_RS06730	COG1215	transferase activity, transferring glycosyl groups
SPN23F_RS06740	COG3475	LICD family
SPN23F_RS06750	COG0077	Prephenate dehydratase
SPN23F_RS06755	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SPN23F_RS06770	COG0287	Prephenate dehydrogenase
SPN23F_RS06795	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPN23F_RS06805	COG1131	(ABC) transporter
SPN23F_RS06845	COG3842	ATPase activity
SPN23F_RS06860	COG3527	Alpha-acetolactate decarboxylase
SPN23F_RS06865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPN23F_RS06870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN23F_RS06875	COG0704	Plays a role in the regulation of phosphate uptake
SPN23F_RS06880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPN23F_RS06885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPN23F_RS06890	COG0581	inorganic phosphate transmembrane transporter activity
SPN23F_RS06900	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPN23F_RS06905	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPN23F_RS06905	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPN23F_RS06910	COG0483	inositol monophosphate 1-phosphatase activity
SPN23F_RS06920	COG1393	Belongs to the ArsC family
SPN23F_RS06930	COG0647	UMP catabolic process
SPN23F_RS06940	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPN23F_RS06990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPN23F_RS07000	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPN23F_RS07025	COG0826	peptidase U32
SPN23F_RS07035	COG0826	peptidase U32
SPN23F_RS07065	COG1132	(ABC) transporter
SPN23F_RS07080	COG1129	ABC transporter
SPN23F_RS07120	COG2188	Transcriptional regulator
SPN23F_RS07125	COG0697	spore germination
SPN23F_RS07130	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPN23F_RS07145	COG0561	phosphatase activity
SPN23F_RS07180	COG0492	ferredoxin-NADP+ reductase activity
SPN23F_RS07190	COG1126	abc transporter atp-binding protein
SPN23F_RS07200	COG1393	Belongs to the ArsC family
SPN23F_RS07220	COG1272	protein, Hemolysin III
SPN23F_RS07250	COG3976	FMN-binding domain protein
SPN23F_RS07250	COG1053	succinate dehydrogenase
SPN23F_RS07250	COG0431	NADPH-dependent FMN reductase
SPN23F_RS07275	COG0656	L-ascorbic acid biosynthetic process
SPN23F_RS07280	COG0726	polysaccharide deacetylase
SPN23F_RS07305	COG3335	DDE superfamily endonuclease
SPN23F_RS07345	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPN23F_RS07385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPN23F_RS07395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN23F_RS07400	COG1126	abc transporter atp-binding protein
SPN23F_RS07410	COG0457	Tetratricopeptide repeat
SPN23F_RS07415	COG0628	permease
SPN23F_RS07420	COG2706	6-phosphogluconolactonase activity
SPN23F_RS07485	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPN23F_RS07510	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPN23F_RS07515	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SPN23F_RS07520	COG0626	cystathionine gamma-synthase activity
SPN23F_RS07525	COG1132	(ABC) transporter
SPN23F_RS07530	COG4166	transmembrane transport
SPN23F_RS07535	COG2244	polysaccharide biosynthetic process
SPN23F_RS07540	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPN23F_RS07565	COG2827	Endonuclease containing a URI domain
SPN23F_RS07570	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPN23F_RS07575	COG1098	S1 RNA binding domain
SPN23F_RS07585	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPN23F_RS07590	COG0629	single-stranded DNA binding
SPN23F_RS07600	COG0017	Asparaginyl-tRNA synthetase
SPN23F_RS07610	COG0436	Aminotransferase
SPN23F_RS07635	COG3711	transcriptional antiterminator
SPN23F_RS07655	COG0242	peptide deformylase activity
SPN23F_RS07660	COG0625	glutathione transferase activity
SPN23F_RS07670	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPN23F_RS07675	COG0488	(ABC) transporter
SPN23F_RS07680	COG0617	tRNA 3'-terminal CCA addition
SPN23F_RS07690	COG1307	EDD domain protein, DegV family
SPN23F_RS07710	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPN23F_RS07720	COG0492	ferredoxin-NADP+ reductase activity
SPN23F_RS07725	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPN23F_RS07725	COG5263	repeat protein
SPN23F_RS07905	COG0270	DNA (cytosine-5-)-methyltransferase activity
SPN23F_RS07910	COG0629	single-stranded DNA binding
SPN23F_RS07965	COG0582	viral genome integration into host DNA
SPN23F_RS07975	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SPN23F_RS07985	COG0251	oxidation-reduction process
SPN23F_RS08005	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPN23F_RS08015	COG5263	repeat protein
SPN23F_RS08015	COG4193	domain, Protein
SPN23F_RS08025	COG3935	DnaD domain protein
SPN23F_RS08040	COG2226	methyltransferase
SPN23F_RS08050	COG3842	ATPase activity
SPN23F_RS08060	COG1335	isochorismatase
SPN23F_RS08070	COG0513	Belongs to the DEAD box helicase family
SPN23F_RS08075	COG2223	nitrite transmembrane transporter activity
SPN23F_RS08080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPN23F_RS08085	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPN23F_RS08090	COG3442	glutamine amidotransferase
SPN23F_RS08095	COG0006	proline dipeptidase activity
SPN23F_RS08100	COG2801	Transposase and inactivated derivatives
SPN23F_RS08115	COG4720	Psort location CytoplasmicMembrane, score
SPN23F_RS08120	COG0351	phosphomethylpyrimidine kinase
SPN23F_RS08145	COG2824	Alkylphosphonate utilization operon protein PhnA
SPN23F_RS08165	COG0463	Glycosyl transferase, family 2
SPN23F_RS08170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPN23F_RS08175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPN23F_RS08180	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SPN23F_RS08185	COG2384	SAM-dependent methyltransferase
SPN23F_RS08190	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SPN23F_RS08195	COG0204	Acyl-transferase
SPN23F_RS08210	COG2910	NAD(P)H-binding
SPN23F_RS08230	COG5002	protein histidine kinase activity
SPN23F_RS08235	COG0745	RESPONSE REGULATOR receiver
SPN23F_RS08250	COG1959	2 iron, 2 sulfur cluster binding
SPN23F_RS08305	COG3590	peptidase
SPN23F_RS08320	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPN23F_RS08325	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SPN23F_RS08335	COG1136	(ABC) transporter
SPN23F_RS08335	COG0577	efflux transmembrane transporter activity
SPN23F_RS08380	COG3599	regulation of cell shape
SPN23F_RS08400	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPN23F_RS08420	COG1051	belongs to the nudix hydrolase family
SPN23F_RS08425	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPN23F_RS08440	COG0768	penicillin binding
SPN23F_RS08455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPN23F_RS08475	COG2731	YhcH YjgK YiaL family protein
SPN23F_RS08480	COG0395	ABC-type sugar transport system, permease component
SPN23F_RS08485	COG1175	transmembrane transport
SPN23F_RS08495	COG2190	(PTS) system
SPN23F_RS08495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN23F_RS08495	COG1263	PTS System
SPN23F_RS08505	COG0673	inositol 2-dehydrogenase activity
SPN23F_RS08510	COG4409	exo-alpha-(2->6)-sialidase activity
SPN23F_RS08520	COG1175	transmembrane transport
SPN23F_RS08525	COG1653	transport
SPN23F_RS08550	COG3458	cephalosporin-C deacetylase activity
SPN23F_RS08555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPN23F_RS08570	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPN23F_RS08575	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPN23F_RS08580	COG0653	protein targeting
SPN23F_RS08590	COG1131	(ABC) transporter
SPN23F_RS08630	COG0778	Nitroreductase
SPN23F_RS08635	COG1484	DNA-dependent DNA replication
SPN23F_RS08650	COG1725	Transcriptional regulator
SPN23F_RS08655	COG1131	(ABC) transporter
SPN23F_RS08665	COG1668	transmembrane transport
SPN23F_RS08670	COG4152	abc transporter atp-binding protein
SPN23F_RS08690	COG1940	carbohydrate kinase activity
SPN23F_RS08695	COG2190	(PTS) system
SPN23F_RS08695	COG1263	PTS System
SPN23F_RS08695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN23F_RS08705	COG1621	beta-fructofuranosidase activity
SPN23F_RS08710	COG1609	Transcriptional regulator
SPN23F_RS08720	COG3425	synthase
SPN23F_RS08750	COG0515	serine threonine protein kinase
SPN23F_RS08750	COG2815	serine threonine protein kinase
SPN23F_RS08755	COG0631	protein serine/threonine phosphatase activity
SPN23F_RS08760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPN23F_RS08760	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPN23F_RS08770	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPN23F_RS08780	COG0194	GDP metabolic process
SPN23F_RS08825	COG2226	methyltransferase
SPN23F_RS08830	COG0799	negative regulation of ribosome biogenesis
SPN23F_RS08840	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPN23F_RS08845	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SPN23F_RS08850	COG1534	Rna-binding protein
SPN23F_RS08855	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPN23F_RS08870	COG0668	transmembrane transport
SPN23F_RS08880	COG4129	membrane
SPN23F_RS08900	COG0438	transferase activity, transferring glycosyl groups
SPN23F_RS08905	COG0438	transferase activity, transferring glycosyl groups
SPN23F_RS08910	COG0653	protein targeting
SPN23F_RS08930	COG0201	protein transport
SPN23F_RS08935	COG1215	transferase activity, transferring glycosyl groups
SPN23F_RS08940	COG1442	glycosyl transferase family 8
SPN23F_RS08945	COG1442	glycosyl transferase family 8
SPN23F_RS08950	COG1442	glycosyl transferase family 8
SPN23F_RS08950	COG1216	Glycosyl transferase, family 2
SPN23F_RS08955	COG1442	glycosyl transferase family 8
SPN23F_RS08970	COG1216	Glycosyl transferase, family 2
SPN23F_RS08970	COG1442	glycosyl transferase family 8
SPN23F_RS08975	COG1442	glycosyl transferase family 8
SPN23F_RS08980	COG1216	Glycosyl transferase, family 2
SPN23F_RS08980	COG1442	glycosyl transferase family 8
SPN23F_RS09010	COG3118	belongs to the thioredoxin family
SPN23F_RS09015	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SPN23F_RS09025	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPN23F_RS09040	COG1164	Oligoendopeptidase f
SPN23F_RS09045	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPN23F_RS09105	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPN23F_RS09115	COG1621	beta-fructofuranosidase activity
SPN23F_RS09120	COG1653	transport
SPN23F_RS09125	COG0395	ABC-type sugar transport system, permease component
SPN23F_RS09130	COG4209	transmembrane transport
SPN23F_RS09140	COG3711	transcriptional antiterminator
SPN23F_RS09165	COG3237	CsbD-like
SPN23F_RS09185	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPN23F_RS09195	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN23F_RS09200	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPN23F_RS09205	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN23F_RS09215	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN23F_RS09220	COG1940	carbohydrate kinase activity
SPN23F_RS09220	COG1846	Transcriptional regulator
SPN23F_RS09270	COG0512	Glutamine amidotransferase of anthranilate synthase
SPN23F_RS09275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPN23F_RS09295	COG1285	pathogenesis
SPN23F_RS09300	COG1178	ABC-type Fe3 transport system permease component
SPN23F_RS09320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPN23F_RS09325	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPN23F_RS09330	COG0704	Plays a role in the regulation of phosphate uptake
SPN23F_RS09345	COG5434	Belongs to the glycosyl hydrolase 28 family
SPN23F_RS09360	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SPN23F_RS09365	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPN23F_RS09370	COG1132	(ABC) transporter
SPN23F_RS09375	COG1132	(ABC) transporter
SPN23F_RS09395	COG0708	Exodeoxyribonuclease III
SPN23F_RS09410	COG2233	PERMEase
SPN23F_RS09435	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPN23F_RS09440	COG1609	Transcriptional regulator
SPN23F_RS09445	COG1063	alcohol dehydrogenase
SPN23F_RS09450	COG0789	Transcriptional regulator
SPN23F_RS09455	COG1230	cation diffusion facilitator family transporter
SPN23F_RS09465	COG3201	nicotinamide mononucleotide transporter
SPN23F_RS09470	COG1174	glycine betaine transport
SPN23F_RS09495	COG1363	Peptidase, m42
SPN23F_RS09510	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPN23F_RS09515	COG4605	iron ion homeostasis
SPN23F_RS09520	COG4604	ABC transporter, ATP-binding protein
SPN23F_RS09525	COG4607	ABC-type enterochelin transport system periplasmic component
SPN23F_RS09535	COG1187	pseudouridine synthase activity
SPN23F_RS09555	COG0517	IMP dehydrogenase activity
SPN23F_RS09565	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SPN23F_RS09580	COG0366	Alpha amylase catalytic
SPN23F_RS09585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN23F_RS09585	COG1263	PTS System
SPN23F_RS09590	COG2188	Transcriptional regulator
SPN23F_RS09595	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPN23F_RS09610	COG4608	Belongs to the ABC transporter superfamily
SPN23F_RS09615	COG0444	Belongs to the ABC transporter superfamily
SPN23F_RS09620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPN23F_RS09625	COG0601	transmembrane transport
SPN23F_RS09630	COG0601	transmembrane transport
SPN23F_RS09635	COG4166	transmembrane transport
SPN23F_RS09645	COG0366	Alpha amylase catalytic
SPN23F_RS09655	COG0395	ABC-type sugar transport system, permease component
SPN23F_RS09660	COG1175	transmembrane transport
SPN23F_RS09665	COG1653	transport
SPN23F_RS09670	COG3345	alpha-galactosidase
SPN23F_RS09675	COG2207	Transcriptional regulator
SPN23F_RS09680	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPN23F_RS09680	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPN23F_RS09805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPN23F_RS09855	COG4221	oxidoreductase activity
SPN23F_RS09860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPN23F_RS09865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPN23F_RS09900	COG1132	(ABC) transporter
SPN23F_RS09905	COG1132	(ABC) transporter
SPN23F_RS09995	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPN23F_RS09995	COG5263	repeat protein
SPN23F_RS10015	COG1316	TRANSCRIPTIONal
SPN23F_RS10025	COG0802	atpase or kinase
SPN23F_RS10085	COG1136	(ABC) transporter
SPN23F_RS10085	COG0577	efflux transmembrane transporter activity
SPN23F_RS10115	COG1253	flavin adenine dinucleotide binding
SPN23F_RS10130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPN23F_RS10140	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPN23F_RS10150	COG0742	ribosomal rna small subunit methyltransferase
SPN23F_RS10170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPN23F_RS10175	COG1254	Belongs to the acylphosphatase family
SPN23F_RS10185	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPN23F_RS10195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPN23F_RS10210	COG1564	THIamine pyrophosphokinase
SPN23F_RS10220	COG1162	GTPase activity
SPN23F_RS10255	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SPN23F_RS10260	COG0084	hydrolase, TatD family'
SPN23F_RS10275	COG0436	Aminotransferase
SPN23F_RS10285	COG0589	response to stress
SPN23F_RS10290	COG0561	phosphatase activity
SPN23F_RS10295	COG0252	asparaginase activity
SPN23F_RS10300	COG1609	Transcriptional regulator
SPN23F_RS10305	COG2197	response regulator
SPN23F_RS10310	COG4585	Histidine kinase
SPN23F_RS10315	COG0842	Transport permease protein
SPN23F_RS10320	COG1131	(ABC) transporter
SPN23F_RS10420	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPN23F_RS10425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPN23F_RS10430	COG0564	pseudouridine synthase activity
SPN23F_RS10440	COG0577	efflux transmembrane transporter activity
SPN23F_RS10455	COG0157	Belongs to the NadC ModD family
SPN23F_RS10465	COG4133	protoheme IX ABC transporter activity
SPN23F_RS10470	COG2188	Transcriptional regulator
SPN23F_RS10475	COG2723	6-phospho-beta-galactosidase activity
SPN23F_RS10480	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN23F_RS10490	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPN23F_RS10495	COG1454	alcohol dehydrogenase
SPN23F_RS10495	COG1012	belongs to the aldehyde dehydrogenase family
SPN23F_RS10505	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPN23F_RS10515	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SPN23F_RS10545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPN23F_RS10555	COG3037	sugar-specific permease SgaT UlaA
SPN23F_RS10565	COG1847	R3H domain protein
SPN23F_RS10570	COG0706	membrane insertase activity
SPN23F_RS10620	COG4537	Required for transformation and DNA binding
SPN23F_RS10625	COG1459	type II secretion system
SPN23F_RS10630	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPN23F_RS10640	COG1063	alcohol dehydrogenase
SPN23F_RS10665	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SPN23F_RS10670	COG3759	membrane
SPN23F_RS10685	COG0131	Imidazoleglycerol-phosphate dehydratase
SPN23F_RS10685	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SPN23F_RS10690	COG0534	Mate efflux family protein
SPN23F_RS10805	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPN23F_RS10810	COG1132	(ABC) transporter
SPN23F_RS10820	COG1132	(ABC) transporter
SPN23F_RS10830	COG1438	arginine binding
SPN23F_RS10855	COG0745	RESPONSE REGULATOR receiver
SPN23F_RS10860	COG5002	protein histidine kinase activity
SPN23F_RS10865	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPN23F_RS10870	COG0573	inorganic phosphate transmembrane transporter activity
SPN23F_RS10880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPN23F_RS10885	COG0704	Plays a role in the regulation of phosphate uptake
SPN23F_RS10905	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPN23F_RS10915	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPN23F_RS10930	COG0697	spore germination
SPN23F_RS10935	COG4499	WXG100 protein secretion system (Wss), protein YukC
SPN23F_RS10935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPN23F_RS10945	COG2217	Heavy metal translocating P-type atpase
SPN23F_RS10955	COG2226	methyltransferase
SPN23F_RS10975	COG0058	SHG alpha-glucan phosphorylase activity
SPN23F_RS10980	COG1640	4-alpha-glucanotransferase
SPN23F_RS10985	COG2182	Extracellular solute-binding protein
SPN23F_RS10990	COG1175	transmembrane transport
SPN23F_RS10995	COG3833	ABC-type maltose transport systems, permease component
SPN23F_RS11000	COG5521	maltodextrose utilization protein MalA
SPN23F_RS11005	COG1609	Transcriptional regulator
SPN23F_RS11020	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPN23F_RS11055	COG1476	TRANSCRIPTIONal
SPN23F_RS11095	COG2151	metal-sulfur cluster biosynthetic enzyme
SPN23F_RS11105	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPN23F_RS11110	COG3959	Transketolase, thiamine diphosphate binding domain
SPN23F_RS11125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPN23F_RS11145	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPN23F_RS11190	COG0383	alpha-mannosidase activity
SPN23F_RS11200	COG3537	Alpha-1,2-mannosidase
SPN23F_RS11220	COG0549	Belongs to the carbamate kinase family
SPN23F_RS11225	COG1288	antiporter activity
SPN23F_RS11230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPN23F_RS11245	COG3583	domain protein
SPN23F_RS11245	COG3064	Membrane
SPN23F_RS11245	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPN23F_RS11255	COG1454	alcohol dehydrogenase
SPN23F_RS11275	COG3716	PTS system mannose fructose sorbose family IID component
SPN23F_RS11285	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN23F_RS11305	COG1070	Carbohydrate kinase
SPN23F_RS11315	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPN23F_RS11315	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPN23F_RS11320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPN23F_RS11325	COG1121	(ABC) transporter
SPN23F_RS11330	COG1846	Transcriptional regulator
SPN23F_RS11335	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPN23F_RS11345	COG1696	Membrane protein involved in D-alanine export
SPN23F_RS11360	COG2211	Major facilitator Superfamily
SPN23F_RS11370	COG3344	reverse transcriptase
SPN23F_RS11390	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPN23F_RS11395	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SPN23F_RS11415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPN23F_RS11425	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPN23F_RS11430	COG5002	protein histidine kinase activity
SPN23F_RS11435	COG0745	RESPONSE REGULATOR receiver
SPN23F_RS11445	COG0542	response to heat
SPN23F_RS11450	COG4463	regulation of RNA biosynthetic process
SPN23F_RS11455	COG1116	anion transmembrane transporter activity
SPN23F_RS11460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SPN23F_RS11465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SPN23F_RS11485	COG0305	Participates in initiation and elongation during chromosome replication
SPN23F_RS11505	COG1040	competence protein
SPN23F_RS11510	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPN23F_RS11515	COG1739	Uncharacterized protein family UPF0029
SPN23F_RS11530	COG3335	DDE superfamily endonuclease
SPN23F_RS11550	COG3942	CHAP domain
SPN23F_RS11560	COG1792	Involved in formation and maintenance of cell shape
SPN23F_RS11565	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPN23F_RS11570	COG1122	ATPase activity
SPN23F_RS11575	COG1122	ATPase activity
SPN23F_RS11580	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPN23F_RS11590	COG0612	Peptidase, M16
SPN23F_RS11595	COG0612	Peptidase, M16
SPN23F_RS11600	COG2501	S4 domain
SPN23F_RS11610	COG0516	GMP reductase activity
SPN23F_RS11610	COG0517	IMP dehydrogenase activity
SPN23F_RS11615	COG0180	Tryptophanyl-tRNA synthetase
SPN23F_RS11620	COG0488	(ABC) transporter
SPN23F_RS11630	COG1511	domain protein
SPN23F_RS11640	COG1511	domain protein
SPN23F_RS11685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPN23F_RS11690	COG1475	DNA binding