locus-tag class description CWI64_RS00035 ENOG4105CVR type I restriction-modification system CWI64_RS00065 ENOG4107SCJ type I restriction enzyme EcoKI subunit R CWI64_RS00070 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) CWI64_RS00090 ENOG4105CA9 Pyruvate kinase CWI64_RS00140 ENOG4108NNR transporter substrate-binding protein CWI64_RS00145 ENOG4108PJD permease CWI64_RS00180 ENOG4105C19 ABC transporter CWI64_RS00205 ENOG4105CXN decarboxylase CWI64_RS00215 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CWI64_RS00240 ENOG410667J hydrolase CWI64_RS00265 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CWI64_RS00270 ENOG4105C34 Pseudouridine synthase CWI64_RS00275 ENOG4105E8R UPF0173 metal-dependent hydrolase CWI64_RS00290 ENOG4105II7 pyrroline-5-carboxylate reductase CWI64_RS00300 ENOG4105FA2 dna polymerase iii CWI64_RS00310 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CWI64_RS00340 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CWI64_RS00350 ENOG4105QNR S1 RNA binding domain protein CWI64_RS00360 ENOG4105C9A Phoh family CWI64_RS00395 ENOG41068WN CWI64_RS00400 ENOG4105KQC Competence protein CWI64_RS00405 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 CWI64_RS00415 ENOG4105DA5 (ABC) transporter CWI64_RS00445 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) CWI64_RS00450 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) CWI64_RS00455 ENOG4105IEH endo-beta-N-acetylglucosaminidase CWI64_RS00470 ENOG4107YR5 Diacylglycerol kinase CWI64_RS00480 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CWI64_RS00485 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CWI64_RS00490 ENOG4105C6X Major Facilitator CWI64_RS00495 ENOG410861F 50S ribosomal protein L33 CWI64_RS00505 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CWI64_RS00515 ENOG41088CC tellurite resistance protein tehB CWI64_RS00560 ENOG4108Z66 YbaK ebsC protein CWI64_RS00580 ENOG4108YZ4 nudix hydrolase CWI64_RS00590 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CWI64_RS00600 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CWI64_RS00605 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CWI64_RS00625 ENOG4107QIV Cytochrome c biogenesis protein CWI64_RS00630 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CWI64_RS00635 ENOG4105CUB amino acid CWI64_RS00640 ENOG4105DSE periplasmic solute binding protein CWI64_RS00690 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) CWI64_RS00700 ENOG410807C QueT transporter CWI64_RS00715 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CWI64_RS00725 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CWI64_RS00730 ENOG41069HH 4-oxalocrotonate tautomerase CWI64_RS00735 ENOG4107104 thymidine kinase CWI64_RS00745 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CWI64_RS00770 ENOG41065S2 pneumococcal vaccine antigen CWI64_RS00780 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CWI64_RS00805 ENOG4105DQ5 transport system permease protein CWI64_RS00810 ENOG4105TVJ transport system, permease CWI64_RS00815 ENOG4105E0A ABC, transporter CWI64_RS00855 ENOG4105MN3 Resolvase CWI64_RS00880 ENOG4106ZEE Diacylglycerol kinase CWI64_RS00900 ENOG4108WZA zeta toxin CWI64_RS00910 ENOG4105ESI atpase involved in dna repair CWI64_RS00925 ENOG4105MU5 relaxase mobilization nuclease domain protein CWI64_RS00990 ENOG4108IMY Transcriptional regulator CWI64_RS01015 ENOG4105CNI cell division protein FtsW CWI64_RS01020 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) CWI64_RS01045 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CWI64_RS01050 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CWI64_RS01055 ENOG4105VG1 fes assembly suf system protein CWI64_RS01060 ENOG4105W2C Glycosyl transferase CWI64_RS01065 ENOG4105BZF Glycosyl transferase (Group 1 CWI64_RS01110 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CWI64_RS01125 ENOG4105C4R Atp-dependent dna helicase CWI64_RS01155 ENOG4105C3J Cysteine desulfurase CWI64_RS01160 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CWI64_RS01180 ENOG4105EMS pseudouridine synthase CWI64_RS01185 ENOG4108IJ2 phosphate acetyltransferase CWI64_RS01225 ENOG4105DTN riboflavin biosynthesis protein ribF CWI64_RS01230 ENOG4108JYZ YitT family CWI64_RS01235 ENOG4108RCR degv family CWI64_RS01240 ENOG4105K70 DNA-binding protein CWI64_RS01245 ENOG4105C5H ABC transporter CWI64_RS01265 ENOG4108IUM Glycogen debranching enzyme CWI64_RS01270 ENOG4105C26 Dehydrogenase CWI64_RS01280 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) CWI64_RS01365 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) CWI64_RS01385 ENOG4105DF9 Lipoate-protein, ligase CWI64_RS01395 ENOG4105C7S Dehydrogenase CWI64_RS01400 ENOG4105CPP Dehydrogenase, E1 component CWI64_RS01405 ENOG4107RUY (E1 component), alpha subunit CWI64_RS01410 ENOG4107QMU Mate efflux family protein CWI64_RS01420 ENOG4105CD3 dihydroorotase CWI64_RS01425 ENOG4108Z4K mutator MutT protein CWI64_RS01445 ENOG4105VDH Dihydroxyacetone kinase CWI64_RS01460 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CWI64_RS01465 ENOG4105KRI phosphocarrier protein (HPr CWI64_RS01470 ENOG4105WAZ (Glutaredoxin-like protein) NrdH CWI64_RS01475 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CWI64_RS01480 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CWI64_RS01520 ENOG4105CID antiterminator CWI64_RS01525 ENOG4105D2M Aldolase CWI64_RS01575 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) CWI64_RS01580 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CWI64_RS01585 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) CWI64_RS01590 ENOG4105DX0 Hemolysin A CWI64_RS01625 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CWI64_RS01645 ENOG4108Z6X (sortase) family CWI64_RS01650 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CWI64_RS01675 ENOG4105Q2H domain protein CWI64_RS01680 ENOG4105BZU Histidine kinase CWI64_RS01685 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CWI64_RS01690 ENOG4105CEN a g-specific adenine glycosylase CWI64_RS01705 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CWI64_RS01710 ENOG4105FH5 Membrane CWI64_RS01715 ENOG4105RNB CWI64_RS01750 ENOG4105E5Q amino acid AbC transporter CWI64_RS01755 ENOG4105CDA abc transporter atp-binding protein CWI64_RS01760 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CWI64_RS01765 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CWI64_RS01770 ENOG410667J hydrolase CWI64_RS01775 ENOG4108HCJ Hydrolase CWI64_RS01780 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) CWI64_RS01805 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 CWI64_RS01820 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CWI64_RS01830 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CWI64_RS01850 ENOG4106N3A copper homeostasis protein cutc CWI64_RS01855 ENOG4105WD1 Membrane CWI64_RS01860 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CWI64_RS01875 ENOG4105C79 DNA protecting protein DprA CWI64_RS01890 ENOG4108KN0 Choline kinase CWI64_RS01895 ENOG4105EJJ Dehydrogenase CWI64_RS01910 ENOG4105KPE licD family CWI64_RS01915 ENOG4105KPE licD family CWI64_RS01925 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CWI64_RS01940 ENOG4105CSM endonuclease III CWI64_RS01955 ENOG4105C5H ABC transporter CWI64_RS01965 ENOG4108V0P LemA family CWI64_RS01980 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY CWI64_RS01995 ENOG4105DCI Phosphohydrolase CWI64_RS02020 ENOG4105WT3 Transcriptional regulator CWI64_RS02035 ENOG4106A8V Protein CrcB homolog CWI64_RS02045 ENOG4105CQC Prephenate dehydratase CWI64_RS02055 ENOG4105SFS phosphoesterase RecJ domain protein CWI64_RS02075 ENOG4107R37 Glutamate dehydrogenase CWI64_RS02090 ENOG4108JJA ABC, transporter CWI64_RS02130 ENOG4105CBX hi0933 family CWI64_RS02145 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component CWI64_RS02155 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) CWI64_RS02185 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CWI64_RS02195 ENOG4105CJA serine threonine protein kinase CWI64_RS02245 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CWI64_RS02260 ENOG4105BZ1 (ABC) transporter CWI64_RS02265 ENOG4105E0X reductase CWI64_RS02280 ENOG4105D6E homoserine dehydrogenase CWI64_RS02305 ENOG4107XU6 Glycosyl transferase (Group 1 CWI64_RS02310 ENOG4105KPE licD family CWI64_RS02315 ENOG4108RCF TRANSCRIPTIONal CWI64_RS02320 ENOG4105CQC Prephenate dehydratase CWI64_RS02325 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CWI64_RS02340 ENOG4105EVN Prephenate dehydrogenase CWI64_RS02365 ENOG4105DR4 Methyltransferase CWI64_RS02405 ENOG4108HM4 ABC transporter CWI64_RS02415 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component CWI64_RS02420 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CWI64_RS02435 ENOG4107FQX Alpha-acetolactate decarboxylase CWI64_RS02450 ENOG4107R0W ABC transporter CWI64_RS02455 ENOG4108UTW Plays a role in the regulation of phosphate uptake CWI64_RS02460 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CWI64_RS02465 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CWI64_RS02470 ENOG4105E2Z phosphate ABC transporter (Permease CWI64_RS02475 ENOG4105C8U phosphate abc transporter CWI64_RS02480 ENOG4105CVA phosphate CWI64_RS02485 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CWI64_RS02490 ENOG4105ECY inositol monophosphatase CWI64_RS02500 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) CWI64_RS02510 ENOG4105D4U had-superfamily hydrolase, subfamily iia CWI64_RS02520 ENOG4105CSA Coproporphyrinogen iii oxidase CWI64_RS02565 ENOG4105D9U N-acetyltransferase CWI64_RS02575 ENOG4105DAP Nicotinate phosphoribosyltransferase CWI64_RS02585 ENOG41067QW Transcriptional regulator CWI64_RS02610 ENOG4105CFP Peptidase U32 CWI64_RS02650 ENOG4108UZ3 Transporter CWI64_RS02655 ENOG4107QK9 Beta-lactamase CWI64_RS02670 ENOG4108HCJ Hydrolase CWI64_RS02700 ENOG4105C2N RNA methyltransferase TrmH family group 3 CWI64_RS02705 ENOG4105C3M thioredoxin reductase CWI64_RS02715 ENOG4105CDA abc transporter atp-binding protein CWI64_RS02720 ENOG4105E5Q amino acid AbC transporter CWI64_RS02725 ENOG41080E8 Transcriptional regulator, Spx MgsR family CWI64_RS02730 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CWI64_RS02745 ENOG4108UT2 hemolysin iii CWI64_RS02760 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CWI64_RS02790 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) CWI64_RS02825 ENOG4108ZJ4 polysaccharide deacetylase CWI64_RS02855 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CWI64_RS02905 ENOG4106TNF Periplasmic binding protein CWI64_RS02910 ENOG4105CDA abc transporter atp-binding protein CWI64_RS02915 ENOG4105E5Q amino acid AbC transporter CWI64_RS02930 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CWI64_RS03020 ENOG4105C0D helicase CWI64_RS03025 ENOG4105C87 Aminotransferase class I and II CWI64_RS03030 ENOG4105C28 cystathionine CWI64_RS03035 ENOG4105BZ1 (ABC) transporter CWI64_RS03045 ENOG4105BZ1 (ABC) transporter CWI64_RS03050 ENOG4105DIB Oligopeptide-binding protein CWI64_RS03060 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CWI64_RS03085 ENOG4105VC4 domain protein CWI64_RS03090 ENOG41060K3 Methyltransferase CWI64_RS03095 ENOG41060GV RNA binding s1 domain protein CWI64_RS03105 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) CWI64_RS03110 ENOG4108UUM single-stranded DNA-binding protein CWI64_RS03120 ENOG4105C5S asparaginyl-tRNA synthetase CWI64_RS03130 ENOG4105CHM Aminotransferase CWI64_RS03170 ENOG4107YDN peptide deformylase CWI64_RS03190 ENOG4105C5H ABC transporter CWI64_RS03195 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CWI64_RS03205 ENOG4105EPR degv family CWI64_RS03225 ENOG4105C8B TIGR00159 family CWI64_RS03240 ENOG4105CIE May be required for sporulation (By similarity) CWI64_RS03245 ENOG4105CHW UPF0052 protein CWI64_RS03255 ENOG4105KME endoribonuclease L-psp CWI64_RS03275 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) CWI64_RS03310 ENOG4105DVA methyltransferase CWI64_RS03315 ENOG4108IJ9 (ABC) transporter CWI64_RS03340 ENOG4105C1J atp-dependent rna helicase CWI64_RS03350 ENOG4107QN2 dihydrolipoyl dehydrogenase CWI64_RS03355 ENOG4105DMS mur ligase CWI64_RS03360 ENOG4105F1K Glutamine amidotransferase CWI64_RS03365 ENOG4105DC7 peptidase M24 CWI64_RS03380 ENOG4105PUK Membrane CWI64_RS03385 ENOG4105DWF phosphomethylpyrimidine kinase CWI64_RS03410 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CWI64_RS03415 ENOG4105CAT Cytidine monophosphate kinase CWI64_RS03440 ENOG4105CKK Glycosyl transferase, family 2 CWI64_RS03445 ENOG4105CMR udp-glucose 4-epimerase CWI64_RS03450 ENOG4107VFR oxidoreductase CWI64_RS03455 ENOG4105EGD dinuclear metal center protein, YbgI family CWI64_RS03485 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic CWI64_RS03490 ENOG4105F6E Acyl-transferase CWI64_RS03505 ENOG4108RYK Nad-dependent epimerase dehydratase CWI64_RS03530 ENOG4105C22 threonyL-tRNA synthetase CWI64_RS03535 ENOG4105EWM Histidine kinase CWI64_RS03540 ENOG4105CJZ response regulator CWI64_RS03555 ENOG4108Z40 Transcriptional regulator CWI64_RS03610 ENOG4105C9K Endothelin-converting enzyme 1 CWI64_RS03615 ENOG4105DIK (ABC) transporter CWI64_RS03620 ENOG4105CC5 ABC transporter CWI64_RS03625 ENOG4105DSE periplasmic solute binding protein CWI64_RS03630 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CWI64_RS03640 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CWI64_RS03680 ENOG4105MMF Cell division protein DIVIVA CWI64_RS03700 ENOG4105DFA alanine racemase domain protein CWI64_RS03725 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) CWI64_RS03740 ENOG4107RF6 penicillin-binding protein CWI64_RS03775 ENOG4108R66 Conserved Protein CWI64_RS03785 ENOG4105DRS transport system, permease CWI64_RS03790 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CWI64_RS03810 ENOG4105CK5 oxidoreductase CWI64_RS03825 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CWI64_RS03830 ENOG4105XN3 extracellular solute-binding protein family 1 CWI64_RS03840 ENOG4108478 ec 3.2.1.18 CWI64_RS03855 ENOG4105I82 acetyl xylan esterase CWI64_RS03865 ENOG4105CB5 ATP-dependent DNA helicase recG CWI64_RS03880 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CWI64_RS03885 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CWI64_RS03890 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CWI64_RS03900 ENOG4105DA5 (ABC) transporter CWI64_RS03930 ENOG4108DBC nitroreductase CWI64_RS03950 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family CWI64_RS03955 ENOG4105CZV ABC transporter CWI64_RS03965 ENOG4105RHA ABC transporter, permease CWI64_RS03970 ENOG4108IUX (ABC) transporter CWI64_RS03990 ENOG4105EVU fructokinase CWI64_RS03995 ENOG4105C5Y PTS System CWI64_RS04010 ENOG4105ETE Transcriptional regulator (LacI family CWI64_RS04020 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase CWI64_RS04045 ENOG4105D9P serine threonine protein kinase CWI64_RS04050 ENOG4108ZF3 Phosphatase CWI64_RS04055 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CWI64_RS04065 ENOG4105C25 Primosomal protein n' CWI64_RS04075 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) CWI64_RS04090 ENOG4105KRQ Addiction module toxin, Txe YoeB family CWI64_RS04105 ENOG4105DXX methyltransferase CWI64_RS04110 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) CWI64_RS04120 ENOG4108WF2 Metal Dependent Phosphohydrolase CWI64_RS04125 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) CWI64_RS04130 ENOG410812S Rna-binding protein CWI64_RS04135 ENOG4105CQW ribosome biogenesis GTPase YqeH CWI64_RS04150 ENOG4105D8X mechanosensitive ion channel CWI64_RS04180 ENOG4105K63 Thioredoxin CWI64_RS04185 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) CWI64_RS04195 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CWI64_RS04205 ENOG4105DPN Oligoendopeptidase f CWI64_RS04210 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CWI64_RS04280 ENOG4105D1H recombination factor protein RarA CWI64_RS04295 ENOG4107YY3 extracellular solute-binding protein family 1 CWI64_RS04300 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component CWI64_RS04320 ENOG4107BMA Transglycosylase associated protein CWI64_RS04340 ENOG41061M1 UPF0337 protein CWI64_RS04355 ENOG4105E6M Sulphatase-modifying factor protein CWI64_RS04365 ENOG4105CK1 PTS System CWI64_RS04370 ENOG4105VCP PTS System CWI64_RS04375 ENOG4105VZJ PTS System CWI64_RS04385 ENOG4105CK1 PTS System CWI64_RS04390 ENOG4105E2R ROK family CWI64_RS04400 ENOG4106A3R peptidase CWI64_RS04445 ENOG4105DDQ anthranilate synthase CWI64_RS04450 ENOG4105CRQ synthase (Component I) CWI64_RS04460 ENOG4105ETE Transcriptional regulator (LacI family CWI64_RS04470 ENOG4105KT7 mgtC SapB transporter CWI64_RS04480 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CWI64_RS04495 ENOG4105CMR udp-glucose 4-epimerase CWI64_RS04500 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase CWI64_RS04505 ENOG4108UTW Plays a role in the regulation of phosphate uptake CWI64_RS04520 ENOG41067D4 cell wall surface anchor family protein CWI64_RS04530 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CWI64_RS04535 ENOG4105D3Q Sugar transferase CWI64_RS04545 ENOG4105BZ1 (ABC) transporter CWI64_RS04550 ENOG4105BZ1 (ABC) transporter CWI64_RS04570 ENOG4105CGK Exodeoxyribonuclease III CWI64_RS04590 ENOG4105C2W permease CWI64_RS04600 ENOG4108HED Type II restriction CWI64_RS04615 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) CWI64_RS04620 ENOG4105CQ4 Transcriptional regulator CWI64_RS04625 ENOG4105CPQ Dehydrogenase CWI64_RS04630 ENOG4105VUF Transcriptional regulator CWI64_RS04635 ENOG4105PGM cation diffusion facilitator family transporter CWI64_RS04650 ENOG4108HQR Glycine betaine CWI64_RS04675 ENOG4105CN9 Peptidase m42 family protein CWI64_RS04695 ENOG4105DHS permease protein CWI64_RS04700 ENOG4105CM4 permease protein CWI64_RS04705 ENOG4108IPW abc transporter atp-binding protein CWI64_RS04720 ENOG4105FE9 pseudouridine synthase CWI64_RS04750 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CWI64_RS04765 ENOG4105CG3 alpha amylase, catalytic region CWI64_RS04775 ENOG4105C5Y PTS System CWI64_RS04780 ENOG4107414 GntR family transcriptional regulator CWI64_RS04785 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CWI64_RS04800 ENOG4108JQ7 (ABC) transporter CWI64_RS04805 ENOG4105C3U ABC transporter CWI64_RS04810 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CWI64_RS04815 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CWI64_RS04820 ENOG4105DIB Oligopeptide-binding protein CWI64_RS04840 ENOG4107RK0 Sucrose phosphorylase CWI64_RS04855 ENOG4107YY3 extracellular solute-binding protein family 1 CWI64_RS04860 ENOG4105DME alpha-galactosidase CWI64_RS04865 ENOG4108R6W Transcriptional regulator, ARAC family CWI64_RS04870 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase CWI64_RS05000 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CWI64_RS05005 ENOG410902V Modulates RecA activity (By similarity) CWI64_RS05035 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) CWI64_RS05045 ENOG4105EMU Dehydrogenase CWI64_RS05050 ENOG4108VDD TRNA binding domain protein CWI64_RS05080 ENOG4105D5G Transposase CWI64_RS05100 ENOG4105ES1 acyl-CoA reductase CWI64_RS05110 ENOG4108M8W Monooxygenase CWI64_RS05155 ENOG4105E5P Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation CWI64_RS05220 ENOG4105WWX n-acetylmuramoyl-l-alanine amidase CWI64_RS05245 ENOG4108KGH TRANSCRIPTIONal CWI64_RS05255 ENOG4105K8N protein family UPF0079, ATPase CWI64_RS05320 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CWI64_RS05360 ENOG4105ZT7 DNA-entry nuclease CWI64_RS05370 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CWI64_RS05380 ENOG41063PX domain protein CWI64_RS05390 ENOG4106H78 methyltransferase CWI64_RS05405 ENOG4105HFZ Membrane CWI64_RS05410 ENOG4108RWN rrna methyltransferase CWI64_RS05425 ENOG4105F1A Pyruvate formate-lyase CWI64_RS05435 ENOG4105DFT pur operon repressor CWI64_RS05455 ENOG4105FJ0 thiamine CWI64_RS05460 ENOG4105DJV ribulose-phosphate 3-epimerase CWI64_RS05465 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CWI64_RS05470 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) CWI64_RS05480 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CWI64_RS05495 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) CWI64_RS05500 ENOG4105F8V Hydrolase, tatD family CWI64_RS05520 ENOG4105CHM Aminotransferase CWI64_RS05530 ENOG4107YZX Universal stress protein CWI64_RS05535 ENOG4108X4Q Hydrolase CWI64_RS05540 ENOG4107RB3 L-asparaginase CWI64_RS05545 ENOG4105ETE Transcriptional regulator (LacI family CWI64_RS05555 ENOG4105BZU Histidine kinase CWI64_RS05560 ENOG4105KCT ABC transporter CWI64_RS05565 ENOG4108M15 ABC transporter CWI64_RS05670 ENOG4105BZ4 penicillin-binding protein CWI64_RS05675 ENOG4105D3G Pseudouridine synthase CWI64_RS05685 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CWI64_RS05690 ENOG4107RBB ABC transporter, permease CWI64_RS05700 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CWI64_RS05720 ENOG4108JJB ABC transporter CWI64_RS05730 ENOG4105CK1 PTS System CWI64_RS05740 ENOG4105VCP PTS System CWI64_RS05745 ENOG4105C0A alcohol dehydrogenase CWI64_RS05755 ENOG4107ZCW Low molecular weight phosphotyrosine protein phosphatase CWI64_RS05765 ENOG4105CV1 Transketolase (EC 2.2.1.1) CWI64_RS05785 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase CWI64_RS05795 ENOG4106ETB IIa component CWI64_RS05805 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC CWI64_RS05820 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CWI64_RS05865 ENOG4106855 Competence protein CWI64_RS05885 ENOG4105E2A Dehydrogenase CWI64_RS05890 ENOG4105CE4 GlcNAc 6-P deacetylase CWI64_RS05915 ENOG4105KA3 membrAne CWI64_RS05930 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CWI64_RS05935 ENOG4105UQX Mate efflux family protein CWI64_RS05940 ENOG4105D98 threonine synthase CWI64_RS06055 ENOG4105BZ1 (ABC) transporter CWI64_RS06065 ENOG4105BZ1 (ABC) transporter CWI64_RS06075 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) CWI64_RS06095 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CWI64_RS06100 ENOG4105BZU Histidine kinase CWI64_RS06105 ENOG4107S17 Phosphate-binding protein CWI64_RS06110 ENOG4105C8U phosphate abc transporter CWI64_RS06120 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CWI64_RS06125 ENOG4108UTW Plays a role in the regulation of phosphate uptake CWI64_RS06145 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CWI64_RS06155 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CWI64_RS06170 ENOG4108UZ3 Transporter CWI64_RS06175 ENOG4105BZ4 penicillin-binding protein CWI64_RS06195 ENOG4105DHI Methyltransferase CWI64_RS06215 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) CWI64_RS06220 ENOG4107SBB 4-alpha-glucanotransferase (EC 2.4.1.25) CWI64_RS06225 ENOG4107FKK extracellular solute-binding protein family 1 CWI64_RS06230 ENOG4105D56 permease protein CWI64_RS06235 ENOG4105EG2 ABC transporter, permease CWI64_RS06245 ENOG4108VP7 maltodextrose utilization protein MalA CWI64_RS06250 ENOG4105FKQ transcriptional regulator CWI64_RS06260 ENOG4107AYK membrAne CWI64_RS06295 ENOG4105VZ8 Transcriptional regulator CWI64_RS06330 ENOG4105VG1 fes assembly suf system protein CWI64_RS06340 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) CWI64_RS06345 ENOG4108HHA Transketolase CWI64_RS06360 ENOG4106ETB IIa component CWI64_RS06415 ENOG4105C8I hydrolase, family 38 CWI64_RS06425 ENOG4105CWX Alpha-1,2-mannosidase CWI64_RS06450 ENOG4105C5B carbamate kinase CWI64_RS06455 ENOG4105CSX c4-dicarboxylate anaerobic carrier CWI64_RS06460 ENOG4107QSE Dipeptidase CWI64_RS06470 ENOG41069UX Beta-N-acetyl-hexosaminidase CWI64_RS06485 ENOG4105C0A alcohol dehydrogenase CWI64_RS06505 ENOG4105F3R pts system mannose fructose sorbose family iid CWI64_RS06515 ENOG4108IQ3 PTS system CWI64_RS06535 ENOG4105DET Rhamnulokinase CWI64_RS06550 ENOG4105DSE periplasmic solute binding protein CWI64_RS06560 ENOG4105FDK ABC transporter CWI64_RS06565 ENOG41067TZ transcriptional regulator, MarR family CWI64_RS06570 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD CWI64_RS06580 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein CWI64_RS06625 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CWI64_RS06630 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CWI64_RS06650 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CWI64_RS06670 ENOG4108WWS isoprenylcysteine carboxyl methyltransferase CWI64_RS06675 ENOG4105BZU Histidine kinase CWI64_RS06680 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CWI64_RS06695 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CWI64_RS06715 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component CWI64_RS06735 ENOG4105CDU Replicative dna helicase CWI64_RS06755 ENOG41081UC Inherit from COG: Competence protein CWI64_RS06765 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CWI64_RS06800 ENOG4105CE9 30S ribosomal protein S2 CWI64_RS06805 ENOG41068JE domain protein CWI64_RS06815 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CWI64_RS06820 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) CWI64_RS06825 ENOG4108JJB ABC transporter CWI64_RS06830 ENOG4108JJB ABC transporter CWI64_RS06835 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CWI64_RS06850 ENOG4105C1V Peptidase, M16 CWI64_RS06855 ENOG410848D S4 domain protein YaaA CWI64_RS06865 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CWI64_RS06870 ENOG4105C31 Tryptophanyl-tRNA synthetase CWI64_RS06875 ENOG4105C5H ABC transporter CWI64_RS06890 ENOG4105ECB domain protein CWI64_RS06945 ENOG4105C0H protease CWI64_RS06950 ENOG4105FA0 parb-like partition protein CWI64_RS06960 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CWI64_RS06970 ENOG4105C3G gtp-binding protein CWI64_RS06980 ENOG4108JA2 transcriptioN-repair coupling factor CWI64_RS06985 ENOG41082I2 s4 domain protein CWI64_RS07005 ENOG4108UGV hypoxanthine phosphoribosyltransferase CWI64_RS07010 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CWI64_RS07080 ENOG4107Z0P This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) CWI64_RS07090 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CWI64_RS07115 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CWI64_RS07130 ENOG4105C2M dna polymerase I CWI64_RS07135 ENOG4105K4P CoA-binding domain protein CWI64_RS07145 ENOG4105HMI Membrane CWI64_RS07150 ENOG4105CHM Aminotransferase CWI64_RS07165 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) CWI64_RS07180 ENOG4108JJA ABC, transporter CWI64_RS07185 ENOG4107VK6 Transport protein ComB CWI64_RS07195 ENOG4107QIK phosphoribosylformylglycinamidine synthase CWI64_RS07200 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase CWI64_RS07210 ENOG4108V3E phosphoribosylglycinamide formyltransferase CWI64_RS07225 ENOG4105C12 Phosphoribosylglycinamide synthetase CWI64_RS07240 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CWI64_RS07245 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CWI64_RS07255 ENOG4105C83 adenylosuccinate lyase CWI64_RS07260 ENOG41069UX Beta-N-acetyl-hexosaminidase CWI64_RS07265 ENOG4105FDP GntR family transcriptional regulator CWI64_RS07275 ENOG4108IQ3 PTS system CWI64_RS07280 ENOG4105ETZ PTS System CWI64_RS07285 ENOG4105F3R pts system mannose fructose sorbose family iid CWI64_RS07295 ENOG4105E70 isomerase CWI64_RS07300 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) CWI64_RS07305 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CWI64_RS07310 ENOG4105VPX protein, conserved in bacteria CWI64_RS07340 ENOG4105CZN Potassium uptake protein CWI64_RS07345 ENOG4107ZYR domain protein CWI64_RS07355 ENOG4108SHN Glycosyl transferase, family 2 CWI64_RS07375 ENOG4108YBA Histidine kinase CWI64_RS07405 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component CWI64_RS07455 ENOG4105U3E Transcriptional regulator CWI64_RS07485 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CWI64_RS07490 ENOG4105EJQ L-serine dehydratase CWI64_RS07525 ENOG4108HW3 (ABC) transporter CWI64_RS07620 ENOG4105M6F mutator MutT protein CWI64_RS07625 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CWI64_RS07665 ENOG41072GX Peptidase M22 Glycoprotease CWI64_RS07675 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CWI64_RS07725 ENOG4105C6Y Udp-glucose 6-dehydrogenase CWI64_RS07730 ENOG4105WT3 Transcriptional regulator CWI64_RS07765 ENOG4105EAB amino acid AbC transporter CWI64_RS07770 ENOG4105D01 (LipO)protein CWI64_RS07775 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) CWI64_RS07780 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CWI64_RS07800 ENOG4105C2F Histidine kinase CWI64_RS07805 ENOG4107VQW regulatoR CWI64_RS07815 ENOG4105MTF NrdI protein CWI64_RS07825 ENOG4105K3M )-transporter CWI64_RS07855 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CWI64_RS07895 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CWI64_RS07900 ENOG4108R6K riboflavin synthase, subunit alpha CWI64_RS07905 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CWI64_RS07915 ENOG4108R3E Dna-3-methyladenine glycosylase i CWI64_RS07940 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CWI64_RS07945 ENOG4105DC7 peptidase M24 CWI64_RS07955 ENOG410888K transcriptional regulator, Spx CWI64_RS07980 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CWI64_RS07990 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CWI64_RS08005 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase CWI64_RS08020 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) CWI64_RS08055 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) CWI64_RS08080 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal CWI64_RS08120 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) CWI64_RS08135 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CWI64_RS08145 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) CWI64_RS08160 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) CWI64_RS08165 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CWI64_RS08175 ENOG4105VUC UPF0237 protein CWI64_RS08200 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CWI64_RS08205 ENOG4105C4Y ABC transporter CWI64_RS08215 ENOG4105F1A Pyruvate formate-lyase CWI64_RS08220 ENOG4105N2W Transcriptional regulator CWI64_RS08225 ENOG4105DKT Transcriptional regulator CWI64_RS08230 ENOG4105VCP PTS System CWI64_RS08235 ENOG4105VZJ PTS System CWI64_RS08240 ENOG4105CK1 PTS System CWI64_RS08260 ENOG4105C8T Leucyl-tRNA synthetase CWI64_RS08290 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CWI64_RS08295 ENOG4105KNE Phosphatidate cytidylyltransferase CWI64_RS08300 ENOG4105DZP Membrane-associated zinc metalloprotease CWI64_RS08310 ENOG4105CS2 ec 3.2.1.21 CWI64_RS08315 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CWI64_RS08325 ENOG4108IUM Glycogen debranching enzyme CWI64_RS08350 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CWI64_RS08370 ENOG4105C88 aminopeptidase CWI64_RS08375 ENOG4107BMA Transglycosylase associated protein CWI64_RS08390 ENOG4105CTZ aminopeptidase c CWI64_RS08395 ENOG4105F3R pts system mannose fructose sorbose family iid CWI64_RS08400 ENOG4105ETZ PTS System CWI64_RS08415 ENOG4105DQF Hydrolase CWI64_RS08420 ENOG4105C7N Xanthine uracil vitamin C permease CWI64_RS08430 ENOG4105EEI dihydropteroate synthase CWI64_RS08435 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CWI64_RS08445 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CWI64_RS08455 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) CWI64_RS08480 ENOG4106AXJ AraC family transcriptional regulator CWI64_RS08500 ENOG4105C5Y PTS System CWI64_RS08510 ENOG4107UWA esterase CWI64_RS08565 ENOG4108MRH transcriptional regulatory protein CWI64_RS08600 ENOG4105CS2 ec 3.2.1.21 CWI64_RS08605 ENOG4105W3H MtN3 and saliva related transmembrane protein CWI64_RS08615 ENOG4105EMD TRANSCRIPTIONal CWI64_RS08630 ENOG4105CK1 PTS System CWI64_RS08650 ENOG4108V06 Glutathione peroxidase CWI64_RS08655 ENOG4106AM8 polysaccharide lyase family 8 CWI64_RS08700 ENOG4105EP8 Glycosyl Hydrolase Family 88 CWI64_RS08705 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB CWI64_RS08710 ENOG4105ETZ PTS System CWI64_RS08715 ENOG4105F3R pts system mannose fructose sorbose family iid CWI64_RS08730 ENOG4108M60 Transcriptional regulator CWI64_RS08760 ENOG41068DC Essential cell division protein (By similarity) CWI64_RS08765 ENOG4105CJN penicillin-binding protein CWI64_RS08795 ENOG4105CG3 alpha amylase, catalytic region CWI64_RS08800 ENOG4105DIB Oligopeptide-binding protein CWI64_RS08810 ENOG4105EKQ RNA-directed DNA polymerase CWI64_RS08850 ENOG4105KPE licD family CWI64_RS08870 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CWI64_RS08875 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CWI64_RS08885 ENOG4105C1B dTDP-glucose 4-6-dehydratase CWI64_RS08890 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase CWI64_RS08905 ENOG4105E5H Transposase CWI64_RS08915 ENOG4105DIB Oligopeptide-binding protein CWI64_RS08925 ENOG4105ESP cell wall surface anchor family protein CWI64_RS08930 ENOG4105BZ4 penicillin-binding protein CWI64_RS08955 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CWI64_RS08960 ENOG41070VT CWI64_RS08965 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CWI64_RS08970 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CWI64_RS09035 ENOG4105ENE Histidine kinase CWI64_RS09040 ENOG4105WH1 Two component transcriptional regulator luxr family CWI64_RS09080 ENOG4105CTS PTS system mannitol-specific CWI64_RS09085 ENOG4105EMD TRANSCRIPTIONal CWI64_RS09090 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein CWI64_RS09105 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CWI64_RS09110 ENOG4105C7H Helicase, RecD TraA family CWI64_RS09115 ENOG4105C3F Signal peptidase i CWI64_RS09140 ENOG4105BZG amino acid carrier protein CWI64_RS09165 ENOG4105CFH Aspartokinase CWI64_RS09175 ENOG4105CGU Enoyl-CoA hydratase CWI64_RS09180 ENOG4105NTK Transcriptional repressor Mpra CWI64_RS09195 ENOG4105EA8 2-Nitropropane dioxygenase CWI64_RS09200 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CWI64_RS09205 ENOG4105CHR reductase CWI64_RS09225 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CWI64_RS09230 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) CWI64_RS09270 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CWI64_RS09305 ENOG4105VB9 50S ribosomal protein l28 CWI64_RS09315 ENOG4105DP4 dak2 domain fusion protein ylov CWI64_RS09325 ENOG4108ZP8 Acetolactate synthase small subunit CWI64_RS09345 ENOG4105C7B Threonine dehydratase CWI64_RS09370 ENOG4105E5Q amino acid AbC transporter CWI64_RS09400 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CWI64_RS09410 ENOG4105C6N Formate acetyltransferase CWI64_RS09445 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) CWI64_RS09450 ENOG4105C1A potassium transporter peripheral membrane CWI64_RS09465 ENOG4108JJB ABC transporter CWI64_RS09480 ENOG4108SAX Membrane CWI64_RS09485 ENOG410841Q phosphoesterase PA-phosphatase related protein CWI64_RS09495 ENOG4108Z7F N-acetyltransferase CWI64_RS09505 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CWI64_RS09515 ENOG4108478 ec 3.2.1.18 CWI64_RS09530 ENOG4105KV4 Transcriptional regulator CWI64_RS09535 ENOG4105C5F glutamine synthetase CWI64_RS09560 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CWI64_RS09570 ENOG4107QTH restriction modification system DNA specificity domain CWI64_RS09585 ENOG4108F3G Type I restriction-modification system, R subunit CWI64_RS09620 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CWI64_RS09630 ENOG4105K59 histidine triad (HIT) protein CWI64_RS09675 ENOG4107VK6 Transport protein ComB CWI64_RS09740 ENOG4108TYN CAAX amino terminal protease family protein CWI64_RS09760 ENOG4105CHV Transcription elongation factor NusA CWI64_RS09765 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination CWI64_RS09775 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) CWI64_RS09825 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CWI64_RS09835 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CWI64_RS09865 ENOG4105CID antiterminator CWI64_RS09870 ENOG4105C5Y PTS System CWI64_RS09885 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 CWI64_RS09890 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CWI64_RS09905 ENOG4105KDP XRE family CWI64_RS09910 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) CWI64_RS09915 ENOG4105SYT Methylenetetrahydrofolate reductase CWI64_RS09930 ENOG4105D7W serine acetyltransferase CWI64_RS09945 ENOG4105C8N cysteinyl-tRNA synthetase CWI64_RS09950 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) CWI64_RS09970 ENOG4107WD8 ABC transporter, permease CWI64_RS09980 ENOG4107WD8 ABC transporter, permease CWI64_RS09985 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CWI64_RS09990 ENOG4105BZU Histidine kinase CWI64_RS09995 ENOG4105D2N Aldolase CWI64_RS10000 ENOG4105E3J oxidoreductase CWI64_RS10005 ENOG4105DRP amino acid AbC transporter CWI64_RS10010 ENOG4105DRP amino acid AbC transporter CWI64_RS10015 ENOG4107RP9 extracellular solute-binding protein, family 3 CWI64_RS10025 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CWI64_RS10035 ENOG4107UWA esterase CWI64_RS10080 ENOG4108RG0 uracil-dna glycosylase CWI64_RS10095 ENOG4105CWM branched-chain amino acid transport system II carrier protein CWI64_RS10100 ENOG4105DER m42 family CWI64_RS10150 ENOG4108IUW ABC transporter CWI64_RS10175 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin CWI64_RS10190 ENOG4105DT3 PTS system, galactitol-specific IIc component CWI64_RS10200 ENOG4105CNT hydrolase family 2 CWI64_RS10240 ENOG4105EEQ Na H antiporter CWI64_RS10250 ENOG4107QIV Cytochrome c biogenesis protein CWI64_RS10255 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CWI64_RS10260 ENOG4105E0X reductase CWI64_RS10270 ENOG4105EQD regulatoR CWI64_RS10275 ENOG4105C2F Histidine kinase CWI64_RS10285 ENOG4105EEN pathogenesis CWI64_RS10290 ENOG4105CRQ synthase (Component I) CWI64_RS10305 ENOG4105DKQ ROK family CWI64_RS10325 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CWI64_RS10330 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase CWI64_RS10340 ENOG4108IXY short-chain dehydrogenase reductase CWI64_RS10355 ENOG4105WZW rhodanese family CWI64_RS10370 ENOG4105CI3 gtp-binding protein typa CWI64_RS10390 ENOG4105C19 ABC transporter CWI64_RS10405 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) CWI64_RS10445 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CWI64_RS10470 ENOG4105CJ1 ABC, transporter CWI64_RS10475 ENOG4105CT1 (ABC) transporter CWI64_RS10485 ENOG4105E5Q amino acid AbC transporter CWI64_RS10530 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) CWI64_RS10545 ENOG4108JJB ABC transporter CWI64_RS10555 ENOG4105ETU transcriptional activator (TenA CWI64_RS10570 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) CWI64_RS10580 ENOG4105NA0 Transcriptional regulator CWI64_RS10590 ENOG4105C59 p-type ATPase CWI64_RS10595 ENOG4105C7K acetolactate synthase CWI64_RS10610 ENOG4105CS2 ec 3.2.1.21 CWI64_RS10615 ENOG4105DG6 mannose-6-phosphate isomerase CWI64_RS10625 ENOG4107TXC Transcriptional regulator CWI64_RS10635 ENOG4105CBX hi0933 family CWI64_RS10640 ENOG4108S8M degv family CWI64_RS10650 ENOG4108UK2 deaminase CWI64_RS10655 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) CWI64_RS10680 ENOG4105C32 Amino acid ABC transporter (Permease) CWI64_RS10685 ENOG4105CF8 branched-chain amino acid ABC transporter, permease CWI64_RS10690 ENOG4105C0Z ABC transporter CWI64_RS10695 ENOG4108IV0 ABC, transporter CWI64_RS10710 ENOG4105CAK Cell division ATP-binding protein ftsE CWI64_RS10715 ENOG4105CRP Part of the ABC transporter FtsEX involved in CWI64_RS10720 ENOG4105CI1 PTS System CWI64_RS10730 ENOG4105C1J atp-dependent rna helicase CWI64_RS10745 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) CWI64_RS10755 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CWI64_RS10760 ENOG4105MMD transcriptional regulator CWI64_RS10765 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs CWI64_RS10775 ENOG4105C5H ABC transporter CWI64_RS10805 ENOG4105VB6 UPF0109 protein CWI64_RS10830 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase CWI64_RS10840 ENOG4105VEM Conserved domain protein CWI64_RS10850 ENOG4105VKD bioY protein CWI64_RS10855 ENOG4105DC8 reductase CWI64_RS10860 ENOG4107X8C Efflux transporter RND family MFP subunit CWI64_RS10865 ENOG4105C19 ABC transporter CWI64_RS10870 ENOG4107RBB ABC transporter, permease CWI64_RS10880 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CWI64_RS10900 ENOG4107RGM aldo keto reductase CWI64_RS10910 ENOG41061TZ Short-chain dehydrogenase reductase Sdr CWI64_RS10935 ENOG4108STX response regulator CWI64_RS10940 ENOG4105US7 Histidine kinase CWI64_RS10970 ENOG4108Z0Z intracellular protease Pfpi family CWI64_RS10980 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CWI64_RS11015 ENOG4105M6F mutator MutT protein CWI64_RS11025 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CWI64_RS11030 ENOG4107IN1 Protein of unknown function (DUF1797) CWI64_RS11035 ENOG4105E5Q amino acid AbC transporter CWI64_RS11040 ENOG4105CDA abc transporter atp-binding protein CWI64_RS11045 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CWI64_RS11050 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) CWI64_RS11070 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) CWI64_RS11090 ENOG4105E5P Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation CWI64_RS11115 ENOG4105CS9 pantothenic acid kinase CWI64_RS11125 ENOG4107Y49 methyltransferase CWI64_RS11130 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) CWI64_RS11140 ENOG4105KG3 cytidine deaminase CWI64_RS11145 ENOG4105DIH basic membrane CWI64_RS11150 ENOG4108JQ9 ABC transporter CWI64_RS11155 ENOG4105UIB (ABC) transporter CWI64_RS11175 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CWI64_RS11180 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CWI64_RS11185 ENOG4105CM2 brancheD-chain amino acid aminotransferase CWI64_RS11190 ENOG4105DIB Oligopeptide-binding protein CWI64_RS11225 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CWI64_RS11235 ENOG4108ZGC gaf domain protein CWI64_RS11240 ENOG4105C6E dna polymerase iii CWI64_RS11255 ENOG4105JRK feS assembly protein SufD CWI64_RS11265 ENOG4108UNV SUF system FeS assembly protein, NifU family CWI64_RS11270 ENOG4105DIW FeS assembly protein SUFB CWI64_RS11280 ENOG4105C02 permease CWI64_RS11295 ENOG4105N2W Transcriptional regulator CWI64_RS11300 ENOG4105DE4 1-phosphofructokinase CWI64_RS11305 ENOG4105DM4 PTS System CWI64_RS11310 ENOG4105CNU cell division protein FtsK CWI64_RS11320 ENOG4105C3J Cysteine desulfurase CWI64_RS11345 ENOG4105CVR type I restriction-modification system CWI64_RS11375 ENOG4107SCJ type I restriction enzyme EcoKI subunit R CWI64_RS11585 ENOG4105EAC phosphoserine phosphatase CWI64_RS11590 ENOG4105EAC phosphoserine phosphatase CWI64_RS11620 ENOG4105DQ6 Transposase CWI64_RS11700 ENOG4105DQ6 Transposase CWI64_RS11705 ENOG4105DQ6 Transposase