locus-tag	class	description
SPCG_RS00010	COG0592	DNA-directed DNA polymerase activity
SPCG_RS00020	COG0012	GTP binding
SPCG_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPCG_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPCG_RS00060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SPCG_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPCG_RS00115	COG3335	DDE superfamily endonuclease
SPCG_RS00150	COG0756	dUTP diphosphatase activity
SPCG_RS00160	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SPCG_RS00180	COG2801	Transposase and inactivated derivatives
SPCG_RS00190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPCG_RS00210	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPCG_RS00210	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPCG_RS00215	COG1832	CoA-binding protein
SPCG_RS00225	COG2855	membrane
SPCG_RS00230	COG0436	Aminotransferase
SPCG_RS00245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPCG_RS00265	COG2274	protein secretion by the type I secretion system
SPCG_RS00270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPCG_RS00275	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SPCG_RS00280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPCG_RS00285	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SPCG_RS00295	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPCG_RS00310	COG0151	Belongs to the GarS family
SPCG_RS00315	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPCG_RS00330	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPCG_RS00335	COG3064	Membrane
SPCG_RS00335	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPCG_RS00335	COG3583	domain protein
SPCG_RS00350	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPCG_RS00355	COG3715	PTS system
SPCG_RS00360	COG3716	PTS system mannose fructose sorbose family IID component
SPCG_RS00370	COG2222	sugar isomerase
SPCG_RS00380	COG2514	catechol 2,3-dioxygenase activity
SPCG_RS00385	COG1937	Protein conserved in bacteria
SPCG_RS00410	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPCG_RS00415	COG0569	domain protein
SPCG_RS00425	COG1215	transferase activity, transferring glycosyl groups
SPCG_RS00445	COG5002	protein histidine kinase activity
SPCG_RS00465	COG4209	transmembrane transport
SPCG_RS00470	COG0395	ABC-type sugar transport system, permease component
SPCG_RS00475	COG1653	transport
SPCG_RS00505	COG1695	Transcriptional regulator
SPCG_RS00530	COG0546	phosphoglycolate phosphatase activity
SPCG_RS00535	COG1760	l-serine dehydratase
SPCG_RS00540	COG1760	l-serine dehydratase
SPCG_RS00570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPCG_RS00575	COG0137	argininosuccinate synthase activity
SPCG_RS00670	COG0494	nUDIX hydrolase
SPCG_RS00675	COG0445	tRNA wobble uridine modification
SPCG_RS00705	COG1214	PFAM Peptidase M22, glycoprotease
SPCG_RS00745	COG0438	transferase activity, transferring glycosyl groups
SPCG_RS00780	COG1396	sequence-specific DNA binding
SPCG_RS00825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPCG_RS00830	COG1464	Belongs to the NlpA lipoprotein family
SPCG_RS00835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPCG_RS00840	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPCG_RS00865	COG1674	ftsk spoiiie
SPCG_RS00870	COG2946	Replication initiation factor
SPCG_RS00900	COG0741	lytic transglycosylase activity
SPCG_RS00900	COG0791	NLP P60 protein
SPCG_RS00995	COG1780	Probably involved in ribonucleotide reductase function
SPCG_RS01025	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPCG_RS01025	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPCG_RS01045	COG2818	Glycosylase
SPCG_RS01070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPCG_RS01075	COG0006	proline dipeptidase activity
SPCG_RS01080	COG1393	Belongs to the ArsC family
SPCG_RS01105	COG0285	dihydrofolate synthase activity
SPCG_RS01115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPCG_RS01180	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPCG_RS01205	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SPCG_RS01245	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SPCG_RS01260	COG0201	protein transport
SPCG_RS01270	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SPCG_RS01275	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SPCG_RS01285	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SPCG_RS01290	COG0202	RNA polymerase activity
SPCG_RS01300	COG3830	Belongs to the UPF0237 family
SPCG_RS01345	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPCG_RS01350	COG1349	DNA-binding transcription factor activity
SPCG_RS01360	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPCG_RS01365	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPCG_RS01370	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPCG_RS01375	COG1882	Formate acetyltransferase
SPCG_RS01420	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPCG_RS01425	COG4589	Belongs to the CDS family
SPCG_RS01430	COG0750	zinc metalloprotease
SPCG_RS01440	COG2723	6-phospho-beta-galactosidase activity
SPCG_RS01445	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPCG_RS01455	COG1523	belongs to the glycosyl hydrolase 13 family
SPCG_RS01480	COG2176	DNA-directed DNA polymerase activity
SPCG_RS01500	COG2309	aminopeptidase activity
SPCG_RS01505	COG2261	transglycosylase associated protein
SPCG_RS01515	COG1187	pseudouridine synthase activity
SPCG_RS01525	COG3579	cysteine-type endopeptidase activity
SPCG_RS01530	COG3716	PTS system mannose fructose sorbose family IID component
SPCG_RS01535	COG3715	PTS system
SPCG_RS01550	COG1064	alcohol dehydrogenase
SPCG_RS01555	COG0561	phosphatase activity
SPCG_RS01560	COG2252	PERMEase
SPCG_RS01570	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SPCG_RS01575	COG0285	dihydrofolate synthase activity
SPCG_RS01585	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SPCG_RS01585	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPCG_RS01595	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPCG_RS01605	COG2723	6-phospho-beta-galactosidase activity
SPCG_RS01615	COG2723	6-phospho-beta-galactosidase activity
SPCG_RS01630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPCG_RS01630	COG3711	transcriptional antiterminator
SPCG_RS01645	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPCG_RS01660	COG0386	Belongs to the glutathione peroxidase family
SPCG_RS01665	COG5492	domain, Protein
SPCG_RS01690	COG1028	Short-chain dehydrogenase reductase Sdr
SPCG_RS01700	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SPCG_RS01705	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPCG_RS01710	COG3715	PTS system
SPCG_RS01715	COG3716	PTS system mannose fructose sorbose family IID component
SPCG_RS01730	COG1609	Transcriptional regulator
SPCG_RS01755	COG4839	cell division protein FtsL
SPCG_RS01760	COG0768	penicillin binding
SPCG_RS01790	COG0366	Alpha amylase catalytic
SPCG_RS01795	COG4166	transmembrane transport
SPCG_RS01830	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SPCG_RS01845	COG1216	Glycosyl transferase, family 2
SPCG_RS01850	COG1216	Glycosyl transferase, family 2
SPCG_RS01850	COG1442	glycosyl transferase family 8
SPCG_RS01870	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SPCG_RS01895	COG4166	transmembrane transport
SPCG_RS01900	COG0366	Alpha amylase catalytic
SPCG_RS01905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPCG_RS01930	COG0116	Belongs to the methyltransferase superfamily
SPCG_RS01940	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SPCG_RS01945	COG0745	RESPONSE REGULATOR receiver
SPCG_RS01995	COG4585	Histidine kinase
SPCG_RS02000	COG2197	response regulator
SPCG_RS02035	COG2801	Transposase and inactivated derivatives
SPCG_RS02055	COG2213	PTS system mannitol-specific
SPCG_RS02060	COG3711	transcriptional antiterminator
SPCG_RS02065	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPCG_RS02090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPCG_RS02095	COG0681	Belongs to the peptidase S26 family
SPCG_RS02120	COG1115	amino acid carrier protein
SPCG_RS02145	COG0527	aspartate kinase activity
SPCG_RS02155	COG1846	Transcriptional regulator
SPCG_RS02165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPCG_RS02175	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPCG_RS02180	COG1028	Short-chain dehydrogenase reductase Sdr
SPCG_RS02185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPCG_RS02200	COG0439	Biotin carboxylase
SPCG_RS02205	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPCG_RS02270	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SPCG_RS02280	COG1461	Dihydroxyacetone kinase
SPCG_RS02285	COG0028	Belongs to the TPP enzyme family
SPCG_RS02290	COG0440	acetolactate synthase activity
SPCG_RS02310	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SPCG_RS02325	COG0765	amino acid transport
SPCG_RS02365	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPCG_RS02370	COG1882	Formate acetyltransferase
SPCG_RS02410	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPCG_RS02415	COG0569	domain protein
SPCG_RS02435	COG1122	ATPase activity
SPCG_RS02450	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPCG_RS02455	COG0671	phosphoesterase, PA-phosphatase related
SPCG_RS02465	COG1247	-acetyltransferase
SPCG_RS02480	COG0504	CTP synthase activity
SPCG_RS02485	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPCG_RS02505	COG0789	Transcriptional regulator
SPCG_RS02510	COG0174	glutamine synthetase
SPCG_RS02520	COG0732	type I restriction modification DNA specificity domain
SPCG_RS02525	COG0732	type I restriction modification DNA specificity domain
SPCG_RS02570	COG0484	heat shock protein binding
SPCG_RS02580	COG0537	adenosine 5'-monophosphoramidase activity
SPCG_RS02585	COG1131	(ABC) transporter
SPCG_RS02610	COG3290	protein histidine kinase activity
SPCG_RS02620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPCG_RS02625	COG2274	protein secretion by the type I secretion system
SPCG_RS02705	COG1266	CAAX protease self-immunity
SPCG_RS02725	COG0195	Participates in both transcription termination and antitermination
SPCG_RS02730	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPCG_RS02795	COG0519	Catalyzes the synthesis of GMP from XMP
SPCG_RS02805	COG0525	valine-tRNA ligase activity
SPCG_RS02825	COG2801	Transposase and inactivated derivatives
SPCG_RS02865	COG3711	transcriptional antiterminator
SPCG_RS02870	COG2190	(PTS) system
SPCG_RS02870	COG1263	PTS System
SPCG_RS02870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPCG_RS02885	COG0456	acetyltransferase
SPCG_RS02890	COG0072	phenylalanine-tRNA ligase activity
SPCG_RS02890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPCG_RS02905	COG3620	sequence-specific DNA binding
SPCG_RS02910	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SPCG_RS02925	COG1045	serine acetyltransferase
SPCG_RS02935	COG0215	cysteine-tRNA ligase activity
SPCG_RS02940	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPCG_RS02960	COG0577	efflux transmembrane transporter activity
SPCG_RS02965	COG1136	(ABC) transporter
SPCG_RS02975	COG0745	RESPONSE REGULATOR receiver
SPCG_RS02980	COG5002	protein histidine kinase activity
SPCG_RS02985	COG0191	fructose-bisphosphate aldolase activity
SPCG_RS02990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SPCG_RS02995	COG0765	amino acid transport
SPCG_RS03000	COG0765	amino acid transport
SPCG_RS03005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPCG_RS03015	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPCG_RS03015	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPCG_RS03055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPCG_RS03070	COG1573	uracil-dna glycosylase
SPCG_RS03080	COG1114	Component of the transport system for branched-chain amino acids
SPCG_RS03085	COG1363	Peptidase, m42
SPCG_RS03125	COG4555	ABC transporter
SPCG_RS03155	COG1404	Belongs to the peptidase S8 family
SPCG_RS03170	COG3775	system Galactitol-specific IIC component
SPCG_RS03180	COG3250	beta-galactosidase activity
SPCG_RS03200	COG1242	4 iron, 4 sulfur cluster binding
SPCG_RS03205	COG1242	4 iron, 4 sulfur cluster binding
SPCG_RS03210	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPCG_RS03230	COG0785	Cytochrome C biogenesis protein
SPCG_RS03235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPCG_RS03240	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPCG_RS03240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPCG_RS03245	COG2207	Transcriptional regulator
SPCG_RS03245	COG4753	response regulator
SPCG_RS03250	COG2972	Histidine kinase
SPCG_RS03260	COG3064	Membrane
SPCG_RS03265	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPCG_RS03280	COG1940	carbohydrate kinase activity
SPCG_RS03300	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPCG_RS03305	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPCG_RS03315	COG0300	oxidoreductase activity
SPCG_RS03330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPCG_RS03340	COG1187	pseudouridine synthase activity
SPCG_RS03345	COG1217	gtp-binding protein TYPA
SPCG_RS03365	COG1136	(ABC) transporter
SPCG_RS03380	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SPCG_RS03410	COG2826	transposase and inactivated derivatives, IS30 family
SPCG_RS03420	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SPCG_RS03445	COG1131	(ABC) transporter
SPCG_RS03450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPCG_RS03455	COG1126	abc transporter atp-binding protein
SPCG_RS03460	COG0765	amino acid transport
SPCG_RS03470	COG1304	FMN binding
SPCG_RS03480	COG1304	FMN binding
SPCG_RS03500	COG0352	thiamine-phosphate diphosphorylase activity
SPCG_RS03510	COG4172	Belongs to the ABC transporter superfamily
SPCG_RS03520	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SPCG_RS03535	COG0352	thiamine-phosphate diphosphorylase activity
SPCG_RS03555	COG2217	Heavy metal translocating P-type atpase
SPCG_RS03560	COG0028	Belongs to the TPP enzyme family
SPCG_RS03575	COG3335	DDE superfamily endonuclease
SPCG_RS03585	COG2723	6-phospho-beta-galactosidase activity
SPCG_RS03590	COG1482	cell wall glycoprotein biosynthetic process
SPCG_RS03595	COG0733	neurotransmitter:sodium symporter activity
SPCG_RS03605	COG0789	Transcriptional regulator
SPCG_RS03615	COG2081	HI0933 family
SPCG_RS03620	COG1307	EDD domain protein, DegV family
SPCG_RS03630	COG2131	deaminase
SPCG_RS03635	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SPCG_RS03675	COG0517	IMP dehydrogenase activity
SPCG_RS03675	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPCG_RS03675	COG0617	tRNA 3'-terminal CCA addition
SPCG_RS03680	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SPCG_RS03685	COG2884	Cell division ATP-binding protein ftsE
SPCG_RS03690	COG2177	Part of the ABC transporter FtsEX involved in
SPCG_RS03695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPCG_RS03695	COG2190	(PTS) system
SPCG_RS03695	COG1263	PTS System
SPCG_RS03705	COG0513	Belongs to the DEAD box helicase family
SPCG_RS03715	COG0167	dihydroorotate dehydrogenase activity
SPCG_RS03725	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SPCG_RS03730	COG4470	Protein conserved in bacteria
SPCG_RS03745	COG0488	(ABC) transporter
SPCG_RS03770	COG1837	Belongs to the UPF0109 family
SPCG_RS03790	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPCG_RS03790	COG1328	CTP reductase activity
SPCG_RS03800	COG4443	Transcriptional Coactivator p15 (PC4)
SPCG_RS03810	COG1268	BioY protein
SPCG_RS03815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPCG_RS03820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPCG_RS03825	COG1136	(ABC) transporter
SPCG_RS03830	COG0577	efflux transmembrane transporter activity
SPCG_RS03835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPCG_RS03835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPCG_RS03855	COG4989	oxidoreductase activity
SPCG_RS03865	COG1028	Short-chain dehydrogenase reductase Sdr
SPCG_RS03890	COG0745	RESPONSE REGULATOR receiver
SPCG_RS03895	COG5002	protein histidine kinase activity
SPCG_RS03920	COG0772	Belongs to the SEDS family
SPCG_RS03925	COG0693	protein deglycase activity
SPCG_RS03935	COG0187	DNA topoisomerase II activity
SPCG_RS03955	COG0494	nUDIX hydrolase
SPCG_RS03970	COG0542	response to heat
SPCG_RS03975	COG4703	Protein of unknown function (DUF1797)
SPCG_RS03980	COG0765	amino acid transport
SPCG_RS03985	COG1126	abc transporter atp-binding protein
SPCG_RS03990	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPCG_RS04000	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SPCG_RS04020	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SPCG_RS04065	COG2813	Specifically methylates the guanine in position
SPCG_RS04070	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SPCG_RS04080	COG0295	cytidine deaminase activity
SPCG_RS04085	COG1744	ABC transporter substrate-binding protein PnrA-like
SPCG_RS04090	COG3845	ABC transporter
SPCG_RS04095	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPCG_RS04100	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPCG_RS04120	COG2801	Transposase and inactivated derivatives
SPCG_RS04130	COG0187	DNA topoisomerase II activity
SPCG_RS04140	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPCG_RS04145	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPCG_RS04150	COG4166	transmembrane transport
SPCG_RS04185	COG0539	negative regulation of cytoplasmic translation
SPCG_RS04205	COG1956	GAF domain-containing protein
SPCG_RS04210	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPCG_RS04225	COG0719	Fe-S assembly protein
SPCG_RS04230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPCG_RS04240	COG0719	Fe-S assembly protein
SPCG_RS04250	COG1686	Belongs to the peptidase S11 family
SPCG_RS04255	COG0628	permease
SPCG_RS04280	COG1349	DNA-binding transcription factor activity
SPCG_RS04285	COG1105	Belongs to the carbohydrate kinase PfkB family
SPCG_RS04290	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPCG_RS04290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPCG_RS04290	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPCG_RS04295	COG0697	spore germination
SPCG_RS04295	COG1674	ftsk spoiiie
SPCG_RS04305	COG1104	cysteine desulfurase activity
SPCG_RS04370	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
SPCG_RS04400	COG1737	Transcriptional regulator
SPCG_RS04405	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SPCG_RS04410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPCG_RS04415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPCG_RS04425	COG4409	exo-alpha-(2->6)-sialidase activity
SPCG_RS04430	COG0673	inositol 2-dehydrogenase activity
SPCG_RS04445	COG1269	ATP hydrolysis coupled proton transport
SPCG_RS04450	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPCG_RS04505	COG1438	arginine binding
SPCG_RS04525	COG0469	pyruvate kinase activity
SPCG_RS04535	COG0582	viral genome integration into host DNA
SPCG_RS04570	COG3689	TIGRFAM TIGR03943 family protein
SPCG_RS04575	COG0701	Predicted permease
SPCG_RS04585	COG3955	Domain of unknown function (DUF1919)
SPCG_RS04590	COG2183	response to ionizing radiation
SPCG_RS04610	COG1136	(ABC) transporter
SPCG_RS04615	COG0577	efflux transmembrane transporter activity
SPCG_RS04630	COG1982	Orn Lys Arg decarboxylase major
SPCG_RS04645	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SPCG_RS04665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPCG_RS04670	COG0561	phosphatase activity
SPCG_RS04690	COG0583	DNA-binding transcription factor activity
SPCG_RS04695	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPCG_RS04700	COG0564	pseudouridine synthase activity
SPCG_RS04705	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPCG_RS04720	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPCG_RS04730	COG0470	DNA polymerase III
SPCG_RS04780	COG0528	UMP kinase activity
SPCG_RS04790	COG2996	Protein conserved in bacteria
SPCG_RS04800	COG1702	phosphate starvation-inducible protein PhoH
SPCG_RS04825	COG0686	Belongs to the AlaDH PNT family
SPCG_RS04830	COG0686	Belongs to the AlaDH PNT family
SPCG_RS04835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPCG_RS04840	COG1555	photosystem II stabilization
SPCG_RS04840	COG1596	polysaccharide export
SPCG_RS04845	COG0658	competence protein
SPCG_RS04845	COG2333	competence protein COMEC
SPCG_RS04855	COG1131	(ABC) transporter
SPCG_RS04885	COG0543	2 iron, 2 sulfur cluster binding
SPCG_RS04890	COG0167	dihydroorotate dehydrogenase activity
SPCG_RS04895	COG4193	domain, Protein
SPCG_RS04895	COG5263	repeat protein
SPCG_RS04900	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPCG_RS04910	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPCG_RS04920	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPCG_RS04925	COG0237	dephospho-CoA kinase activity
SPCG_RS04930	COG2814	Major facilitator Superfamily
SPCG_RS04935	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPCG_RS04945	COG0557	exoribonuclease II activity
SPCG_RS04955	COG0500	methyltransferase
SPCG_RS04955	COG3615	Tellurite resistance protein tehB
SPCG_RS04970	COG4122	O-methyltransferase activity
SPCG_RS04980	COG2801	Transposase and inactivated derivatives
SPCG_RS04995	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SPCG_RS05015	COG0494	nUDIX hydrolase
SPCG_RS05025	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPCG_RS05035	COG2176	DNA-directed DNA polymerase activity
SPCG_RS05040	COG0584	glycerophosphoryl diester phosphodiesterase
SPCG_RS05060	COG0785	Cytochrome C biogenesis protein
SPCG_RS05065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPCG_RS05070	COG0531	amino acid
SPCG_RS05075	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPCG_RS05075	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPCG_RS05130	COG1970	mechanosensitive ion channel activity
SPCG_RS05140	COG4708	membrane
SPCG_RS05155	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPCG_RS05165	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SPCG_RS05170	COG1942	4-Oxalocrotonate Tautomerase
SPCG_RS05175	COG1435	thymidine kinase activity
SPCG_RS05185	COG2890	protein-(glutamine-N5) methyltransferase activity
SPCG_RS05210	COG0741	lytic transglycosylase activity
SPCG_RS05220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPCG_RS05240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPCG_RS05245	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPCG_RS05320	COG1597	lipid kinase activity
SPCG_RS05325	COG0366	Alpha amylase catalytic
SPCG_RS05340	COG1396	sequence-specific DNA binding
SPCG_RS05345	COG0542	response to heat
SPCG_RS05350	COG0613	PHP domain protein
SPCG_RS05355	COG1196	nuclear chromosome segregation
SPCG_RS05370	COG3843	relaxase mobilization nuclease domain protein
SPCG_RS05400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPCG_RS05405	COG2832	Protein of unknown function (DUF454)
SPCG_RS05410	COG3142	Participates in the control of copper homeostasis
SPCG_RS05430	COG0473	3-isopropylmalate dehydrogenase activity
SPCG_RS05440	COG0066	3-isopropylmalate dehydratase activity
SPCG_RS05455	COG1401	restriction endodeoxyribonuclease activity
SPCG_RS05475	COG1196	nuclear chromosome segregation
SPCG_RS05480	COG0561	phosphatase activity
SPCG_RS05485	COG0561	phosphatase activity
SPCG_RS05490	COG0552	protein localization to endoplasmic reticulum
SPCG_RS05495	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPCG_RS05500	COG1126	abc transporter atp-binding protein
SPCG_RS05505	COG0765	amino acid transport
SPCG_RS05535	COG1827	regulation of RNA biosynthetic process
SPCG_RS05545	COG4684	Psort location CytoplasmicMembrane, score
SPCG_RS05550	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPCG_RS05565	COG1194	a g-specific adenine glycosylase
SPCG_RS05570	COG0745	RESPONSE REGULATOR receiver
SPCG_RS05575	COG5002	protein histidine kinase activity
SPCG_RS05580	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPCG_RS05605	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPCG_RS05610	COG3764	Sortase (surface protein transpeptidase)
SPCG_RS05635	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SPCG_RS05670	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPCG_RS05675	COG1438	arginine binding
SPCG_RS05680	COG0497	DNA recombination
SPCG_RS05685	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SPCG_RS05740	COG3684	Belongs to the aldolase LacD family
SPCG_RS05745	COG3711	transcriptional antiterminator
SPCG_RS05760	COG2723	6-phospho-beta-galactosidase activity
SPCG_RS05790	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPCG_RS05795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPCG_RS05800	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPCG_RS05805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPCG_RS05835	COG1011	Hydrolase
SPCG_RS05850	COG1051	belongs to the nudix hydrolase family
SPCG_RS05855	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPCG_RS05865	COG0534	Mate efflux family protein
SPCG_RS05870	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPCG_RS05875	COG0022	dehydrogenase e1 component
SPCG_RS05880	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPCG_RS05885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPCG_RS05890	COG0095	Lipoate-protein ligase
SPCG_RS05910	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPCG_RS05915	COG3064	Membrane
SPCG_RS05920	COG3583	domain protein
SPCG_RS05920	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
SPCG_RS05990	COG0560	Phosphoserine phosphatase
SPCG_RS06010	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SPCG_RS06015	COG1012	belongs to the aldehyde dehydrogenase family
SPCG_RS06030	COG1523	belongs to the glycosyl hydrolase 13 family
SPCG_RS06050	COG0488	(ABC) transporter
SPCG_RS06060	COG1307	EDD domain protein, DegV family
SPCG_RS06065	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPCG_RS06070	COG0196	riboflavin kinase activity
SPCG_RS06105	COG0280	phosphate acetyltransferase
SPCG_RS06110	COG0564	pseudouridine synthase activity
SPCG_RS06120	COG2357	RelA SpoT domain protein
SPCG_RS06130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPCG_RS06135	COG1104	cysteine desulfurase activity
SPCG_RS06155	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPCG_RS06165	COG0210	DNA helicase
SPCG_RS06185	COG0024	Methionine aminopeptidase
SPCG_RS06190	COG4109	DRTGG domain
SPCG_RS06200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPCG_RS06240	COG0438	transferase activity, transferring glycosyl groups
SPCG_RS06245	COG0438	transferase activity, transferring glycosyl groups
SPCG_RS06250	COG2151	metal-sulfur cluster biosynthetic enzyme
SPCG_RS06255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPCG_RS06260	COG0358	DNA primase activity
SPCG_RS06280	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SPCG_RS06285	COG0772	Belongs to the SEDS family
SPCG_RS06310	COG1396	sequence-specific DNA binding
SPCG_RS06370	COG0758	DNA mediated transformation
SPCG_RS06375	COG4750	Nucleotidyl transferase
SPCG_RS06390	COG1063	alcohol dehydrogenase
SPCG_RS06405	COG3475	LICD family
SPCG_RS06410	COG3475	LICD family
SPCG_RS06420	COG0505	Belongs to the CarA family
SPCG_RS06435	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPCG_RS06450	COG0488	(ABC) transporter
SPCG_RS06460	COG1704	LemA family
SPCG_RS06475	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPCG_RS06490	COG1078	dGTPase activity
SPCG_RS06515	COG1396	sequence-specific DNA binding
SPCG_RS06530	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPCG_RS06535	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPCG_RS06540	COG1605	Chorismate mutase
SPCG_RS06540	COG0077	Prephenate dehydratase
SPCG_RS06545	COG0716	FMN binding
SPCG_RS06550	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPCG_RS06565	COG2837	iron assimilation
SPCG_RS06575	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPCG_RS06585	COG4974	Belongs to the 'phage' integrase family
SPCG_RS06600	COG3843	relaxase mobilization nuclease domain protein
SPCG_RS06620	COG0210	DNA helicase
SPCG_RS06655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SPCG_RS06695	COG0542	response to heat
SPCG_RS06700	COG1396	sequence-specific DNA binding
SPCG_RS06820	COG1674	ftsk spoiiie
SPCG_RS06825	COG2946	Replication initiation factor
SPCG_RS06845	COG0456	acetyltransferase
SPCG_RS06910	COG0582	viral genome integration into host DNA
SPCG_RS06935	COG0270	DNA (cytosine-5-)-methyltransferase activity
SPCG_RS06960	COG0402	S-adenosylhomocysteine deaminase activity
SPCG_RS06970	COG1132	(ABC) transporter
SPCG_RS06975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPCG_RS06975	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPCG_RS06995	COG4862	establishment of competence for transformation
SPCG_RS07010	COG1215	transferase activity, transferring glycosyl groups
SPCG_RS07020	COG3475	LICD family
SPCG_RS07030	COG0077	Prephenate dehydratase
SPCG_RS07035	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SPCG_RS07050	COG0287	Prephenate dehydrogenase
SPCG_RS07075	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPCG_RS07090	COG1131	(ABC) transporter
SPCG_RS07130	COG3842	ATPase activity
SPCG_RS07145	COG3527	Alpha-acetolactate decarboxylase
SPCG_RS07150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPCG_RS07155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPCG_RS07160	COG0704	Plays a role in the regulation of phosphate uptake
SPCG_RS07165	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPCG_RS07170	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPCG_RS07175	COG0581	inorganic phosphate transmembrane transporter activity
SPCG_RS07180	COG0573	inorganic phosphate transmembrane transporter activity
SPCG_RS07185	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPCG_RS07190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPCG_RS07190	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPCG_RS07195	COG0483	inositol monophosphate 1-phosphatase activity
SPCG_RS07205	COG1393	Belongs to the ArsC family
SPCG_RS07215	COG0647	UMP catabolic process
SPCG_RS07225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPCG_RS07275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPCG_RS07285	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPCG_RS07310	COG1131	(ABC) transporter
SPCG_RS07320	COG0826	peptidase U32
SPCG_RS07330	COG0826	peptidase U32
SPCG_RS07360	COG1132	(ABC) transporter
SPCG_RS07375	COG1129	ABC transporter
SPCG_RS07420	COG2188	Transcriptional regulator
SPCG_RS07425	COG0697	spore germination
SPCG_RS07430	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPCG_RS07445	COG0561	phosphatase activity
SPCG_RS07475	COG0492	ferredoxin-NADP+ reductase activity
SPCG_RS07485	COG1126	abc transporter atp-binding protein
SPCG_RS07495	COG1393	Belongs to the ArsC family
SPCG_RS07500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SPCG_RS07515	COG1272	protein, Hemolysin III
SPCG_RS07525	COG1136	(ABC) transporter
SPCG_RS07525	COG0577	efflux transmembrane transporter activity
SPCG_RS07560	COG0431	NADPH-dependent FMN reductase
SPCG_RS07560	COG1053	succinate dehydrogenase
SPCG_RS07560	COG3976	FMN-binding domain protein
SPCG_RS07585	COG0656	L-ascorbic acid biosynthetic process
SPCG_RS07590	COG0726	polysaccharide deacetylase
SPCG_RS07610	COG3335	DDE superfamily endonuclease
SPCG_RS07630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPCG_RS07665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPCG_RS07690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPCG_RS07695	COG1126	abc transporter atp-binding protein
SPCG_RS07710	COG0628	permease
SPCG_RS07715	COG2706	6-phosphogluconolactonase activity
SPCG_RS07780	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPCG_RS07805	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPCG_RS07810	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SPCG_RS07815	COG0626	cystathionine gamma-synthase activity
SPCG_RS07820	COG1132	(ABC) transporter
SPCG_RS07830	COG4166	transmembrane transport
SPCG_RS07835	COG2244	polysaccharide biosynthetic process
SPCG_RS07840	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPCG_RS07865	COG2827	Endonuclease containing a URI domain
SPCG_RS07870	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPCG_RS07875	COG1098	S1 RNA binding domain
SPCG_RS07885	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPCG_RS07890	COG0629	single-stranded DNA binding
SPCG_RS07900	COG0017	Asparaginyl-tRNA synthetase
SPCG_RS07910	COG0436	Aminotransferase
SPCG_RS07945	COG0242	peptide deformylase activity
SPCG_RS07950	COG0625	glutathione transferase activity
SPCG_RS07960	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPCG_RS07965	COG0488	(ABC) transporter
SPCG_RS07980	COG1307	EDD domain protein, DegV family
SPCG_RS08000	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPCG_RS08020	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SPCG_RS08030	COG0251	oxidation-reduction process
SPCG_RS08050	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPCG_RS08060	COG5263	repeat protein
SPCG_RS08060	COG4193	domain, Protein
SPCG_RS08070	COG3935	DnaD domain protein
SPCG_RS08085	COG2226	methyltransferase
SPCG_RS08095	COG3842	ATPase activity
SPCG_RS08105	COG1335	isochorismatase
SPCG_RS08115	COG0513	Belongs to the DEAD box helicase family
SPCG_RS08120	COG2223	nitrite transmembrane transporter activity
SPCG_RS08125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPCG_RS08130	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPCG_RS08135	COG3442	glutamine amidotransferase
SPCG_RS08140	COG0006	proline dipeptidase activity
SPCG_RS08145	COG2801	Transposase and inactivated derivatives
SPCG_RS08160	COG4720	Psort location CytoplasmicMembrane, score
SPCG_RS08165	COG0351	phosphomethylpyrimidine kinase
SPCG_RS08190	COG2824	Alkylphosphonate utilization operon protein PhnA
SPCG_RS08215	COG0463	Glycosyl transferase, family 2
SPCG_RS08220	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPCG_RS08225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPCG_RS08230	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SPCG_RS08235	COG2384	SAM-dependent methyltransferase
SPCG_RS08255	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPCG_RS08260	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SPCG_RS08265	COG0204	Acyl-transferase
SPCG_RS08280	COG2910	NAD(P)H-binding
SPCG_RS08295	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SPCG_RS08300	COG5002	protein histidine kinase activity
SPCG_RS08305	COG0745	RESPONSE REGULATOR receiver
SPCG_RS08320	COG1959	2 iron, 2 sulfur cluster binding
SPCG_RS08385	COG3590	peptidase
SPCG_RS08400	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPCG_RS08405	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SPCG_RS08415	COG0577	efflux transmembrane transporter activity
SPCG_RS08415	COG1136	(ABC) transporter
SPCG_RS08460	COG3599	regulation of cell shape
SPCG_RS08480	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPCG_RS08500	COG1051	belongs to the nudix hydrolase family
SPCG_RS08505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPCG_RS08520	COG0768	penicillin binding
SPCG_RS08535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPCG_RS08555	COG2731	YhcH YjgK YiaL family protein
SPCG_RS08560	COG0395	ABC-type sugar transport system, permease component
SPCG_RS08565	COG1175	transmembrane transport
SPCG_RS08575	COG2190	(PTS) system
SPCG_RS08575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPCG_RS08575	COG1263	PTS System
SPCG_RS08585	COG0673	inositol 2-dehydrogenase activity
SPCG_RS08590	COG4409	exo-alpha-(2->6)-sialidase activity
SPCG_RS08600	COG1175	transmembrane transport
SPCG_RS08605	COG1653	transport
SPCG_RS08630	COG3458	cephalosporin-C deacetylase activity
SPCG_RS08640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPCG_RS08655	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPCG_RS08660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPCG_RS08665	COG0653	protein targeting
SPCG_RS08675	COG1131	(ABC) transporter
SPCG_RS08705	COG0778	Nitroreductase
SPCG_RS08710	COG1484	DNA-dependent DNA replication
SPCG_RS08725	COG1725	Transcriptional regulator
SPCG_RS08730	COG1131	(ABC) transporter
SPCG_RS08740	COG1668	transmembrane transport
SPCG_RS08745	COG4152	abc transporter atp-binding protein
SPCG_RS08765	COG1940	carbohydrate kinase activity
SPCG_RS08770	COG2190	(PTS) system
SPCG_RS08770	COG1263	PTS System
SPCG_RS08770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPCG_RS08780	COG1621	beta-fructofuranosidase activity
SPCG_RS08785	COG1609	Transcriptional regulator
SPCG_RS08795	COG3425	synthase
SPCG_RS08825	COG0515	serine threonine protein kinase
SPCG_RS08825	COG2815	serine threonine protein kinase
SPCG_RS08830	COG0631	protein serine/threonine phosphatase activity
SPCG_RS08835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPCG_RS08835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPCG_RS08855	COG0194	GDP metabolic process
SPCG_RS08865	COG4115	mRNA cleavage
SPCG_RS08880	COG2226	methyltransferase
SPCG_RS08885	COG0799	negative regulation of ribosome biogenesis
SPCG_RS08895	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPCG_RS08900	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SPCG_RS08905	COG1534	Rna-binding protein
SPCG_RS08910	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPCG_RS08925	COG0668	transmembrane transport
SPCG_RS08955	COG0438	transferase activity, transferring glycosyl groups
SPCG_RS08960	COG0438	transferase activity, transferring glycosyl groups
SPCG_RS08965	COG0653	protein targeting
SPCG_RS08990	COG1215	transferase activity, transferring glycosyl groups
SPCG_RS08995	COG1215	transferase activity, transferring glycosyl groups
SPCG_RS09000	COG1442	glycosyl transferase family 8
SPCG_RS09005	COG1442	glycosyl transferase family 8
SPCG_RS09010	COG1442	glycosyl transferase family 8
SPCG_RS09015	COG0438	transferase activity, transferring glycosyl groups
SPCG_RS09020	COG1442	glycosyl transferase family 8
SPCG_RS09025	COG1216	Glycosyl transferase, family 2
SPCG_RS09025	COG1442	glycosyl transferase family 8
SPCG_RS09035	COG1442	glycosyl transferase family 8
SPCG_RS09040	COG1442	glycosyl transferase family 8
SPCG_RS09040	COG1216	Glycosyl transferase, family 2
SPCG_RS09075	COG3118	belongs to the thioredoxin family
SPCG_RS09080	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SPCG_RS09090	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPCG_RS09105	COG1164	Oligoendopeptidase f
SPCG_RS09110	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPCG_RS09170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPCG_RS09180	COG1621	beta-fructofuranosidase activity
SPCG_RS09185	COG1653	transport
SPCG_RS09190	COG0395	ABC-type sugar transport system, permease component
SPCG_RS09195	COG4209	transmembrane transport
SPCG_RS09205	COG3711	transcriptional antiterminator
SPCG_RS09230	COG3237	CsbD-like
SPCG_RS09245	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPCG_RS09255	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPCG_RS09260	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPCG_RS09265	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPCG_RS09275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPCG_RS09280	COG1846	Transcriptional regulator
SPCG_RS09280	COG1940	carbohydrate kinase activity
SPCG_RS09290	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SPCG_RS09320	COG0512	Glutamine amidotransferase of anthranilate synthase
SPCG_RS09325	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPCG_RS09350	COG1285	pathogenesis
SPCG_RS09355	COG1178	ABC-type Fe3 transport system permease component
SPCG_RS09380	COG5434	Belongs to the glycosyl hydrolase 28 family
SPCG_RS09395	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SPCG_RS09400	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPCG_RS09405	COG1132	(ABC) transporter
SPCG_RS09410	COG1132	(ABC) transporter
SPCG_RS09425	COG0708	Exodeoxyribonuclease III
SPCG_RS09445	COG2233	PERMEase
SPCG_RS09470	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPCG_RS09475	COG1609	Transcriptional regulator
SPCG_RS09480	COG1063	alcohol dehydrogenase
SPCG_RS09485	COG0789	Transcriptional regulator
SPCG_RS09490	COG1230	cation diffusion facilitator family transporter
SPCG_RS09500	COG3201	nicotinamide mononucleotide transporter
SPCG_RS09505	COG1174	glycine betaine transport
SPCG_RS09530	COG1363	Peptidase, m42
SPCG_RS09545	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPCG_RS09550	COG4605	iron ion homeostasis
SPCG_RS09555	COG4604	ABC transporter, ATP-binding protein
SPCG_RS09560	COG4607	ABC-type enterochelin transport system periplasmic component
SPCG_RS09570	COG1187	pseudouridine synthase activity
SPCG_RS09590	COG0517	IMP dehydrogenase activity
SPCG_RS09600	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SPCG_RS09620	COG0366	Alpha amylase catalytic
SPCG_RS09625	COG1263	PTS System
SPCG_RS09625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPCG_RS09630	COG2188	Transcriptional regulator
SPCG_RS09650	COG4608	Belongs to the ABC transporter superfamily
SPCG_RS09655	COG0444	Belongs to the ABC transporter superfamily
SPCG_RS09660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPCG_RS09665	COG0601	transmembrane transport
SPCG_RS09670	COG4166	transmembrane transport
SPCG_RS09680	COG0366	Alpha amylase catalytic
SPCG_RS09690	COG0395	ABC-type sugar transport system, permease component
SPCG_RS09695	COG1175	transmembrane transport
SPCG_RS09700	COG1653	transport
SPCG_RS09705	COG3345	alpha-galactosidase
SPCG_RS09710	COG2207	Transcriptional regulator
SPCG_RS09715	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPCG_RS09715	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPCG_RS09830	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPCG_RS09835	COG3231	kanamycin kinase activity
SPCG_RS09875	COG4221	oxidoreductase activity
SPCG_RS09880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPCG_RS09885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPCG_RS09925	COG1132	(ABC) transporter
SPCG_RS10020	COG5263	repeat protein
SPCG_RS10020	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPCG_RS10040	COG1316	TRANSCRIPTIONal
SPCG_RS10050	COG0802	atpase or kinase
SPCG_RS10075	COG1136	(ABC) transporter
SPCG_RS10105	COG1253	flavin adenine dinucleotide binding
SPCG_RS10120	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPCG_RS10130	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPCG_RS10140	COG0742	ribosomal rna small subunit methyltransferase
SPCG_RS10160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPCG_RS10165	COG1254	Belongs to the acylphosphatase family
SPCG_RS10175	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPCG_RS10185	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPCG_RS10200	COG1564	THIamine pyrophosphokinase
SPCG_RS10210	COG1162	GTPase activity
SPCG_RS10245	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SPCG_RS10250	COG0084	hydrolase, TatD family'
SPCG_RS10265	COG0436	Aminotransferase
SPCG_RS10275	COG0589	response to stress
SPCG_RS10280	COG0561	phosphatase activity
SPCG_RS10285	COG0252	asparaginase activity
SPCG_RS10295	COG1609	Transcriptional regulator
SPCG_RS10300	COG2197	response regulator
SPCG_RS10305	COG4585	Histidine kinase
SPCG_RS10310	COG0842	Transport permease protein
SPCG_RS10315	COG1131	(ABC) transporter
SPCG_RS10415	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPCG_RS10425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPCG_RS10460	COG0157	Belongs to the NadC ModD family
SPCG_RS10470	COG4133	protoheme IX ABC transporter activity
SPCG_RS10475	COG2188	Transcriptional regulator
SPCG_RS10480	COG2723	6-phospho-beta-galactosidase activity
SPCG_RS10485	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPCG_RS10495	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPCG_RS10500	COG1454	alcohol dehydrogenase
SPCG_RS10500	COG1012	belongs to the aldehyde dehydrogenase family
SPCG_RS10510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPCG_RS10520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SPCG_RS10550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPCG_RS10560	COG3037	sugar-specific permease SgaT UlaA
SPCG_RS10570	COG1847	R3H domain protein
SPCG_RS10575	COG0706	membrane insertase activity
SPCG_RS10625	COG4537	Required for transformation and DNA binding
SPCG_RS10630	COG1459	type II secretion system
SPCG_RS10635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPCG_RS10645	COG1063	alcohol dehydrogenase
SPCG_RS10670	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SPCG_RS10675	COG3759	membrane
SPCG_RS10690	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SPCG_RS10690	COG0131	Imidazoleglycerol-phosphate dehydratase
SPCG_RS10695	COG0534	Mate efflux family protein
SPCG_RS10810	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPCG_RS10815	COG1132	(ABC) transporter
SPCG_RS10825	COG1132	(ABC) transporter
SPCG_RS10835	COG1438	arginine binding
SPCG_RS10855	COG0745	RESPONSE REGULATOR receiver
SPCG_RS10860	COG5002	protein histidine kinase activity
SPCG_RS10865	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPCG_RS10870	COG0573	inorganic phosphate transmembrane transporter activity
SPCG_RS10880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPCG_RS10885	COG0704	Plays a role in the regulation of phosphate uptake
SPCG_RS10905	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPCG_RS10915	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPCG_RS10930	COG0697	spore germination
SPCG_RS10935	COG4499	WXG100 protein secretion system (Wss), protein YukC
SPCG_RS10935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPCG_RS10945	COG2217	Heavy metal translocating P-type atpase
SPCG_RS10955	COG2226	methyltransferase
SPCG_RS10975	COG0058	SHG alpha-glucan phosphorylase activity
SPCG_RS10980	COG1640	4-alpha-glucanotransferase
SPCG_RS10985	COG2182	Extracellular solute-binding protein
SPCG_RS10990	COG1175	transmembrane transport
SPCG_RS10995	COG3833	ABC-type maltose transport systems, permease component
SPCG_RS11000	COG5521	maltodextrose utilization protein MalA
SPCG_RS11005	COG1609	Transcriptional regulator
SPCG_RS11015	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPCG_RS11050	COG1476	TRANSCRIPTIONal
SPCG_RS11085	COG2151	metal-sulfur cluster biosynthetic enzyme
SPCG_RS11100	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPCG_RS11105	COG3959	Transketolase, thiamine diphosphate binding domain
SPCG_RS11120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPCG_RS11140	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPCG_RS11180	COG0383	alpha-mannosidase activity
SPCG_RS11190	COG3537	Alpha-1,2-mannosidase
SPCG_RS11210	COG0549	Belongs to the carbamate kinase family
SPCG_RS11215	COG1288	antiporter activity
SPCG_RS11220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPCG_RS11230	COG3583	domain protein
SPCG_RS11230	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPCG_RS11230	COG3064	Membrane
SPCG_RS11240	COG1454	alcohol dehydrogenase
SPCG_RS11250	COG0235	Class ii aldolase
SPCG_RS11280	COG1175	transmembrane transport
SPCG_RS11285	COG1653	transport
SPCG_RS11290	COG1070	Carbohydrate kinase
SPCG_RS11300	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPCG_RS11300	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPCG_RS11305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPCG_RS11310	COG1121	(ABC) transporter
SPCG_RS11315	COG1846	Transcriptional regulator
SPCG_RS11320	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPCG_RS11330	COG1696	Membrane protein involved in D-alanine export
SPCG_RS11345	COG2211	Major facilitator Superfamily
SPCG_RS11350	COG3344	reverse transcriptase
SPCG_RS11375	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPCG_RS11380	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SPCG_RS11400	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPCG_RS11410	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPCG_RS11415	COG5002	protein histidine kinase activity
SPCG_RS11420	COG0745	RESPONSE REGULATOR receiver
SPCG_RS11435	COG0542	response to heat
SPCG_RS11440	COG4463	regulation of RNA biosynthetic process
SPCG_RS11445	COG1116	anion transmembrane transporter activity
SPCG_RS11450	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SPCG_RS11455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SPCG_RS11475	COG0305	Participates in initiation and elongation during chromosome replication
SPCG_RS11495	COG1040	competence protein
SPCG_RS11500	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPCG_RS11505	COG1739	Uncharacterized protein family UPF0029
SPCG_RS11520	COG3335	DDE superfamily endonuclease
SPCG_RS11540	COG3942	CHAP domain
SPCG_RS11550	COG1792	Involved in formation and maintenance of cell shape
SPCG_RS11555	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPCG_RS11560	COG1122	ATPase activity
SPCG_RS11565	COG1122	ATPase activity
SPCG_RS11570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPCG_RS11580	COG0612	Peptidase, M16
SPCG_RS11585	COG0612	Peptidase, M16
SPCG_RS11590	COG2501	S4 domain
SPCG_RS11600	COG0516	GMP reductase activity
SPCG_RS11600	COG0517	IMP dehydrogenase activity
SPCG_RS11605	COG0180	Tryptophanyl-tRNA synthetase
SPCG_RS11610	COG0488	(ABC) transporter
SPCG_RS11620	COG1511	domain protein
SPCG_RS11630	COG1511	domain protein
SPCG_RS11675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPCG_RS11680	COG1475	DNA binding
SPCG_RS11720	COG0577	efflux transmembrane transporter activity
SPCG_RS11720	COG1136	(ABC) transporter