locus-tag	class	description
L1A12_RS00010	COG0592	DNA-directed DNA polymerase activity
L1A12_RS00020	COG0012	GTP binding
L1A12_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L1A12_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L1A12_RS00055	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L1A12_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L1A12_RS00130	COG0756	dUTP diphosphatase activity
L1A12_RS00140	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
L1A12_RS00155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L1A12_RS00170	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L1A12_RS00170	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L1A12_RS00175	COG1832	CoA-binding protein
L1A12_RS00185	COG2855	membrane
L1A12_RS00190	COG0436	Aminotransferase
L1A12_RS00220	COG2274	protein secretion by the type I secretion system
L1A12_RS00225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L1A12_RS00235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L1A12_RS00240	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
L1A12_RS00250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L1A12_RS00265	COG0151	Belongs to the GarS family
L1A12_RS00275	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L1A12_RS00290	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L1A12_RS00295	COG3064	Membrane
L1A12_RS00295	COG3525	Glycosyl hydrolase, family 20, catalytic domain
L1A12_RS00295	COG3583	domain protein
L1A12_RS00310	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L1A12_RS00315	COG3715	PTS system
L1A12_RS00320	COG3716	PTS system mannose fructose sorbose family IID component
L1A12_RS00330	COG2222	sugar isomerase
L1A12_RS00340	COG2514	catechol 2,3-dioxygenase activity
L1A12_RS00345	COG1937	Protein conserved in bacteria
L1A12_RS00370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L1A12_RS00375	COG0569	domain protein
L1A12_RS00405	COG5002	protein histidine kinase activity
L1A12_RS00435	COG4209	transmembrane transport
L1A12_RS00440	COG0395	ABC-type sugar transport system, permease component
L1A12_RS00445	COG1653	transport
L1A12_RS00475	COG1695	Transcriptional regulator
L1A12_RS00500	COG0546	phosphoglycolate phosphatase activity
L1A12_RS00505	COG1760	l-serine dehydratase
L1A12_RS00510	COG1760	l-serine dehydratase
L1A12_RS00540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1A12_RS00630	COG0494	nUDIX hydrolase
L1A12_RS00635	COG0445	tRNA wobble uridine modification
L1A12_RS00665	COG1214	PFAM Peptidase M22, glycoprotease
L1A12_RS00695	COG0438	transferase activity, transferring glycosyl groups
L1A12_RS00720	COG1396	sequence-specific DNA binding
L1A12_RS00755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1A12_RS00760	COG1464	Belongs to the NlpA lipoprotein family
L1A12_RS00765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L1A12_RS00770	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L1A12_RS00790	COG2972	Histidine kinase
L1A12_RS00795	COG4753	response regulator
L1A12_RS00795	COG2207	Transcriptional regulator
L1A12_RS00805	COG1780	Probably involved in ribonucleotide reductase function
L1A12_RS00835	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L1A12_RS00835	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L1A12_RS00855	COG2818	Glycosylase
L1A12_RS00880	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L1A12_RS00885	COG0006	proline dipeptidase activity
L1A12_RS00895	COG1393	Belongs to the ArsC family
L1A12_RS00920	COG0285	dihydrofolate synthase activity
L1A12_RS00930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L1A12_RS00990	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L1A12_RS01015	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
L1A12_RS01055	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
L1A12_RS01070	COG0201	protein transport
L1A12_RS01080	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
L1A12_RS01085	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L1A12_RS01095	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L1A12_RS01100	COG0202	RNA polymerase activity
L1A12_RS01110	COG3830	Belongs to the UPF0237 family
L1A12_RS01130	COG3842	ATPase activity
L1A12_RS01145	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L1A12_RS01150	COG1349	DNA-binding transcription factor activity
L1A12_RS01160	COG1447	Phosphotransferase system cellobiose-specific component IIA
L1A12_RS01165	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L1A12_RS01170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L1A12_RS01175	COG1882	Formate acetyltransferase
L1A12_RS01225	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L1A12_RS01230	COG4589	Belongs to the CDS family
L1A12_RS01235	COG0750	zinc metalloprotease
L1A12_RS01245	COG2723	6-phospho-beta-galactosidase activity
L1A12_RS01250	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L1A12_RS01260	COG1523	belongs to the glycosyl hydrolase 13 family
L1A12_RS01280	COG2176	DNA-directed DNA polymerase activity
L1A12_RS01300	COG2309	aminopeptidase activity
L1A12_RS01305	COG2261	transglycosylase associated protein
L1A12_RS01310	COG1187	pseudouridine synthase activity
L1A12_RS01315	COG3579	cysteine-type endopeptidase activity
L1A12_RS01320	COG3716	PTS system mannose fructose sorbose family IID component
L1A12_RS01325	COG3715	PTS system
L1A12_RS01335	COG1064	alcohol dehydrogenase
L1A12_RS01340	COG0561	phosphatase activity
L1A12_RS01345	COG2252	PERMEase
L1A12_RS01355	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L1A12_RS01360	COG0285	dihydrofolate synthase activity
L1A12_RS01365	COG0302	gtp cyclohydrolase
L1A12_RS01370	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L1A12_RS01370	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L1A12_RS01380	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L1A12_RS01395	COG2723	6-phospho-beta-galactosidase activity
L1A12_RS01410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L1A12_RS01410	COG3711	transcriptional antiterminator
L1A12_RS01425	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L1A12_RS01425	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L1A12_RS01440	COG0386	Belongs to the glutathione peroxidase family
L1A12_RS01460	COG0800	Aldolase
L1A12_RS01475	COG1028	Short-chain dehydrogenase reductase Sdr
L1A12_RS01485	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
L1A12_RS01490	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L1A12_RS01495	COG3715	PTS system
L1A12_RS01500	COG3716	PTS system mannose fructose sorbose family IID component
L1A12_RS01515	COG1609	Transcriptional regulator
L1A12_RS01545	COG4839	cell division protein FtsL
L1A12_RS01550	COG0768	penicillin binding
L1A12_RS01575	COG0366	Alpha amylase catalytic
L1A12_RS01580	COG4166	transmembrane transport
L1A12_RS01650	COG0366	Alpha amylase catalytic
L1A12_RS01655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L1A12_RS01680	COG0116	Belongs to the methyltransferase superfamily
L1A12_RS01690	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
L1A12_RS01695	COG0745	RESPONSE REGULATOR receiver
L1A12_RS01755	COG4585	Histidine kinase
L1A12_RS01760	COG2197	response regulator
L1A12_RS01775	COG0582	viral genome integration into host DNA
L1A12_RS01785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L1A12_RS01790	COG0681	Belongs to the peptidase S26 family
L1A12_RS01815	COG1115	amino acid carrier protein
L1A12_RS01830	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L1A12_RS01840	COG0527	aspartate kinase activity
L1A12_RS01845	COG1024	Enoyl-CoA hydratase
L1A12_RS01850	COG1846	Transcriptional regulator
L1A12_RS01860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L1A12_RS01870	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L1A12_RS01875	COG1028	Short-chain dehydrogenase reductase Sdr
L1A12_RS01880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L1A12_RS01895	COG0439	Biotin carboxylase
L1A12_RS01900	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
L1A12_RS01965	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L1A12_RS01975	COG1461	Dihydroxyacetone kinase
L1A12_RS01980	COG0028	Belongs to the TPP enzyme family
L1A12_RS01985	COG0440	acetolactate synthase activity
L1A12_RS02005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L1A12_RS02020	COG0765	amino acid transport
L1A12_RS02040	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L1A12_RS02045	COG1882	Formate acetyltransferase
L1A12_RS02060	COG1846	Transcriptional regulator
L1A12_RS02060	COG1940	carbohydrate kinase activity
L1A12_RS02065	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L1A12_RS02075	COG1447	Phosphotransferase system cellobiose-specific component IIA
L1A12_RS02080	COG2723	6-phospho-beta-galactosidase activity
L1A12_RS02085	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L1A12_RS02085	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L1A12_RS02090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L1A12_RS02095	COG0569	domain protein
L1A12_RS02115	COG1122	ATPase activity
L1A12_RS02130	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
L1A12_RS02135	COG0671	phosphoesterase, PA-phosphatase related
L1A12_RS02145	COG1247	-acetyltransferase
L1A12_RS02155	COG0504	CTP synthase activity
L1A12_RS02160	COG1283	sodium-dependent phosphate transmembrane transporter activity
L1A12_RS02180	COG0789	Transcriptional regulator
L1A12_RS02185	COG0174	glutamine synthetase
L1A12_RS02205	COG4974	Belongs to the 'phage' integrase family
L1A12_RS02215	COG0732	type I restriction modification DNA specificity domain
L1A12_RS02240	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L1A12_RS02255	COG0484	heat shock protein binding
L1A12_RS02270	COG0537	adenosine 5'-monophosphoramidase activity
L1A12_RS02275	COG1131	(ABC) transporter
L1A12_RS02300	COG3290	protein histidine kinase activity
L1A12_RS02310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L1A12_RS02345	COG1266	CAAX protease self-immunity
L1A12_RS02365	COG0195	Participates in both transcription termination and antitermination
L1A12_RS02370	COG2740	Nucleic-acid-binding protein implicated in transcription termination
L1A12_RS02430	COG0519	Catalyzes the synthesis of GMP from XMP
L1A12_RS02440	COG0525	valine-tRNA ligase activity
L1A12_RS02460	COG3711	transcriptional antiterminator
L1A12_RS02465	COG1263	PTS System
L1A12_RS02465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L1A12_RS02465	COG2190	(PTS) system
L1A12_RS02485	COG0456	acetyltransferase
L1A12_RS02490	COG0072	phenylalanine-tRNA ligase activity
L1A12_RS02490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L1A12_RS02505	COG3620	sequence-specific DNA binding
L1A12_RS02510	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L1A12_RS02525	COG1045	serine acetyltransferase
L1A12_RS02535	COG0215	cysteine-tRNA ligase activity
L1A12_RS02540	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
L1A12_RS02560	COG0577	efflux transmembrane transporter activity
L1A12_RS02565	COG1136	(ABC) transporter
L1A12_RS02570	COG0577	efflux transmembrane transporter activity
L1A12_RS02580	COG0745	RESPONSE REGULATOR receiver
L1A12_RS02585	COG5002	protein histidine kinase activity
L1A12_RS02590	COG0191	fructose-bisphosphate aldolase activity
L1A12_RS02600	COG0765	amino acid transport
L1A12_RS02605	COG0765	amino acid transport
L1A12_RS02610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1A12_RS02620	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
L1A12_RS02620	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L1A12_RS02650	COG0322	excinuclease ABC activity
L1A12_RS02660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1A12_RS02675	COG1573	uracil-dna glycosylase
L1A12_RS02685	COG1114	Component of the transport system for branched-chain amino acids
L1A12_RS02690	COG1363	Peptidase, m42
L1A12_RS02735	COG4555	ABC transporter
L1A12_RS02765	COG1404	Belongs to the peptidase S8 family
L1A12_RS02780	COG3775	system Galactitol-specific IIC component
L1A12_RS02790	COG3250	beta-galactosidase activity
L1A12_RS02815	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
L1A12_RS02835	COG0785	Cytochrome C biogenesis protein
L1A12_RS02840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L1A12_RS02845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L1A12_RS02845	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L1A12_RS02850	COG2207	Transcriptional regulator
L1A12_RS02850	COG4753	response regulator
L1A12_RS02855	COG2972	Histidine kinase
L1A12_RS02865	COG3064	Membrane
L1A12_RS02870	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L1A12_RS02885	COG1940	carbohydrate kinase activity
L1A12_RS02900	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
L1A12_RS02905	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L1A12_RS02910	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
L1A12_RS02920	COG0300	oxidoreductase activity
L1A12_RS02935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L1A12_RS02945	COG1187	pseudouridine synthase activity
L1A12_RS02950	COG1217	gtp-binding protein TYPA
L1A12_RS02970	COG1136	(ABC) transporter
L1A12_RS02985	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L1A12_RS02995	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L1A12_RS03015	COG1131	(ABC) transporter
L1A12_RS03020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1A12_RS03030	COG4215	(ABC) transporter
L1A12_RS03035	COG4597	amino acid ABC transporter
L1A12_RS03040	COG1304	FMN binding
L1A12_RS03050	COG1304	FMN binding
L1A12_RS03065	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
L1A12_RS03070	COG0352	thiamine-phosphate diphosphorylase activity
L1A12_RS03080	COG4172	Belongs to the ABC transporter superfamily
L1A12_RS03090	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L1A12_RS03105	COG0352	thiamine-phosphate diphosphorylase activity
L1A12_RS03125	COG2217	Heavy metal translocating P-type atpase
L1A12_RS03130	COG0028	Belongs to the TPP enzyme family
L1A12_RS03150	COG1482	cell wall glycoprotein biosynthetic process
L1A12_RS03170	COG2081	HI0933 family
L1A12_RS03175	COG1307	EDD domain protein, DegV family
L1A12_RS03185	COG2131	deaminase
L1A12_RS03190	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
L1A12_RS03230	COG0517	IMP dehydrogenase activity
L1A12_RS03230	COG0617	tRNA 3'-terminal CCA addition
L1A12_RS03230	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L1A12_RS03240	COG2884	Cell division ATP-binding protein ftsE
L1A12_RS03245	COG2177	Part of the ABC transporter FtsEX involved in
L1A12_RS03250	COG1263	PTS System
L1A12_RS03250	COG2190	(PTS) system
L1A12_RS03250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L1A12_RS03260	COG0513	Belongs to the DEAD box helicase family
L1A12_RS03270	COG0167	dihydroorotate dehydrogenase activity
L1A12_RS03280	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L1A12_RS03285	COG4470	Protein conserved in bacteria
L1A12_RS03300	COG0488	(ABC) transporter
L1A12_RS03305	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L1A12_RS03325	COG1837	Belongs to the UPF0109 family
L1A12_RS03350	COG1328	CTP reductase activity
L1A12_RS03350	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L1A12_RS03360	COG4443	Transcriptional Coactivator p15 (PC4)
L1A12_RS03370	COG1268	BioY protein
L1A12_RS03375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L1A12_RS03380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L1A12_RS03385	COG1136	(ABC) transporter
L1A12_RS03390	COG0577	efflux transmembrane transporter activity
L1A12_RS03395	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L1A12_RS03395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L1A12_RS03410	COG4989	oxidoreductase activity
L1A12_RS03420	COG1028	Short-chain dehydrogenase reductase Sdr
L1A12_RS03450	COG0745	RESPONSE REGULATOR receiver
L1A12_RS03455	COG5002	protein histidine kinase activity
L1A12_RS03475	COG0772	Belongs to the SEDS family
L1A12_RS03480	COG0693	protein deglycase activity
L1A12_RS03490	COG0187	DNA topoisomerase II activity
L1A12_RS03510	COG0494	nUDIX hydrolase
L1A12_RS03520	COG0542	response to heat
L1A12_RS03525	COG4703	Protein of unknown function (DUF1797)
L1A12_RS03530	COG0765	amino acid transport
L1A12_RS03535	COG1126	abc transporter atp-binding protein
L1A12_RS03540	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L1A12_RS03545	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L1A12_RS03565	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
L1A12_RS03610	COG2813	Specifically methylates the guanine in position
L1A12_RS03615	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
L1A12_RS03625	COG0295	cytidine deaminase activity
L1A12_RS03630	COG1744	ABC transporter substrate-binding protein PnrA-like
L1A12_RS03635	COG3845	ABC transporter
L1A12_RS03640	COG4603	Belongs to the binding-protein-dependent transport system permease family
L1A12_RS03645	COG1079	Belongs to the binding-protein-dependent transport system permease family
L1A12_RS03665	COG0187	DNA topoisomerase II activity
L1A12_RS03670	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L1A12_RS03675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L1A12_RS03680	COG4166	transmembrane transport
L1A12_RS03715	COG0539	negative regulation of cytoplasmic translation
L1A12_RS03725	COG1956	GAF domain-containing protein
L1A12_RS03730	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L1A12_RS03745	COG0719	Fe-S assembly protein
L1A12_RS03750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L1A12_RS03760	COG0719	Fe-S assembly protein
L1A12_RS03765	COG1686	Belongs to the peptidase S11 family
L1A12_RS03770	COG0628	permease
L1A12_RS03785	COG1349	DNA-binding transcription factor activity
L1A12_RS03790	COG1105	Belongs to the carbohydrate kinase PfkB family
L1A12_RS03795	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L1A12_RS03795	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L1A12_RS03795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L1A12_RS03800	COG0697	spore germination
L1A12_RS03800	COG1674	ftsk spoiiie
L1A12_RS03810	COG1104	cysteine desulfurase activity
L1A12_RS03875	COG1438	arginine binding
L1A12_RS03895	COG0469	pyruvate kinase activity
L1A12_RS03925	COG3689	TIGRFAM TIGR03943 family protein
L1A12_RS03930	COG0701	Predicted permease
L1A12_RS03935	COG2183	response to ionizing radiation
L1A12_RS03955	COG1136	(ABC) transporter
L1A12_RS03960	COG0577	efflux transmembrane transporter activity
L1A12_RS03975	COG1982	Orn Lys Arg decarboxylase major
L1A12_RS03990	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
L1A12_RS04010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L1A12_RS04015	COG0561	phosphatase activity
L1A12_RS04035	COG0583	DNA-binding transcription factor activity
L1A12_RS04040	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L1A12_RS04045	COG0564	pseudouridine synthase activity
L1A12_RS04050	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L1A12_RS04065	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L1A12_RS04075	COG0470	DNA polymerase III
L1A12_RS04095	COG0528	UMP kinase activity
L1A12_RS04105	COG2996	Protein conserved in bacteria
L1A12_RS04115	COG1702	phosphate starvation-inducible protein PhoH
L1A12_RS04135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L1A12_RS04140	COG1555	photosystem II stabilization
L1A12_RS04140	COG1596	polysaccharide export
L1A12_RS04145	COG0658	competence protein
L1A12_RS04145	COG2333	competence protein COMEC
L1A12_RS04155	COG1131	(ABC) transporter
L1A12_RS04185	COG0543	2 iron, 2 sulfur cluster binding
L1A12_RS04190	COG0167	dihydroorotate dehydrogenase activity
L1A12_RS04195	COG5263	repeat protein
L1A12_RS04195	COG4193	domain, Protein
L1A12_RS04200	COG1293	RNA-binding protein homologous to eukaryotic snRNP
L1A12_RS04210	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L1A12_RS04220	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L1A12_RS04225	COG0237	dephospho-CoA kinase activity
L1A12_RS04230	COG2814	Major facilitator Superfamily
L1A12_RS04235	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L1A12_RS04245	COG0557	exoribonuclease II activity
L1A12_RS04255	COG0500	methyltransferase
L1A12_RS04255	COG3615	Tellurite resistance protein tehB
L1A12_RS04270	COG4122	O-methyltransferase activity
L1A12_RS04295	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L1A12_RS04315	COG0494	nUDIX hydrolase
L1A12_RS04325	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L1A12_RS04335	COG2176	DNA-directed DNA polymerase activity
L1A12_RS04340	COG0584	glycerophosphoryl diester phosphodiesterase
L1A12_RS04360	COG0785	Cytochrome C biogenesis protein
L1A12_RS04365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L1A12_RS04370	COG0531	amino acid
L1A12_RS04375	COG3443	Belongs to the bacterial solute-binding protein 9 family
L1A12_RS04375	COG0803	Belongs to the bacterial solute-binding protein 9 family
L1A12_RS04415	COG1970	mechanosensitive ion channel activity
L1A12_RS04425	COG4708	membrane
L1A12_RS04435	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L1A12_RS04445	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L1A12_RS04450	COG1942	4-Oxalocrotonate Tautomerase
L1A12_RS04455	COG1435	thymidine kinase activity
L1A12_RS04460	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L1A12_RS04465	COG2890	protein-(glutamine-N5) methyltransferase activity
L1A12_RS04490	COG0741	lytic transglycosylase activity
L1A12_RS04520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L1A12_RS04525	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L1A12_RS04580	COG1597	lipid kinase activity
L1A12_RS04585	COG0366	Alpha amylase catalytic
L1A12_RS04595	COG1396	sequence-specific DNA binding
L1A12_RS04600	COG0542	response to heat
L1A12_RS04605	COG0613	PHP domain protein
L1A12_RS04625	COG1181	Belongs to the D-alanine--D-alanine ligase family
L1A12_RS04630	COG0148	phosphopyruvate hydratase activity
L1A12_RS04635	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L1A12_RS04640	COG3959	Transketolase, thiamine diphosphate binding domain
L1A12_RS04645	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L1A12_RS04650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L1A12_RS04660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L1A12_RS04675	COG0028	Belongs to the TPP enzyme family
L1A12_RS04675	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
L1A12_RS04690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L1A12_RS04700	COG4555	ABC transporter
L1A12_RS04725	COG1396	sequence-specific DNA binding
L1A12_RS04750	COG0772	Belongs to the SEDS family
L1A12_RS04755	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
L1A12_RS04770	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L1A12_RS04775	COG0358	DNA primase activity
L1A12_RS04780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L1A12_RS04785	COG2151	metal-sulfur cluster biosynthetic enzyme
L1A12_RS04790	COG0438	transferase activity, transferring glycosyl groups
L1A12_RS04795	COG0438	transferase activity, transferring glycosyl groups
L1A12_RS04820	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L1A12_RS04830	COG4109	DRTGG domain
L1A12_RS04835	COG0024	Methionine aminopeptidase
L1A12_RS04845	COG0210	DNA helicase
L1A12_RS04855	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L1A12_RS04875	COG1104	cysteine desulfurase activity
L1A12_RS04880	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L1A12_RS04890	COG2357	RelA SpoT domain protein
L1A12_RS04900	COG0564	pseudouridine synthase activity
L1A12_RS04905	COG0280	phosphate acetyltransferase
L1A12_RS04945	COG0196	riboflavin kinase activity
L1A12_RS04950	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L1A12_RS04955	COG1307	EDD domain protein, DegV family
L1A12_RS04965	COG0488	(ABC) transporter
L1A12_RS04985	COG1523	belongs to the glycosyl hydrolase 13 family
L1A12_RS04990	COG1012	belongs to the aldehyde dehydrogenase family
L1A12_RS04995	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L1A12_RS05005	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L1A12_RS05015	COG0560	Phosphoserine phosphatase
L1A12_RS05020	COG0560	Phosphoserine phosphatase
L1A12_RS05040	COG0582	viral genome integration into host DNA
L1A12_RS05065	COG1074	ATP-dependent DNA helicase activity
L1A12_RS05095	COG0270	DNA (cytosine-5-)-methyltransferase activity
L1A12_RS05180	COG1674	ftsk spoiiie
L1A12_RS05240	COG0741	lytic transglycosylase activity
L1A12_RS05240	COG0791	NLP P60 protein
L1A12_RS05255	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L1A12_RS05295	COG1136	(ABC) transporter
L1A12_RS05355	COG1396	sequence-specific DNA binding
L1A12_RS05360	COG0542	response to heat
L1A12_RS05395	COG1396	sequence-specific DNA binding
L1A12_RS05400	COG0542	response to heat
L1A12_RS05410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L1A12_RS05435	COG3843	relaxase mobilization nuclease domain protein
L1A12_RS05440	COG1396	sequence-specific DNA binding
L1A12_RS05450	COG0582	viral genome integration into host DNA
L1A12_RS05455	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
L1A12_RS05460	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L1A12_RS05475	COG0095	Lipoate-protein ligase
L1A12_RS05480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L1A12_RS05485	COG0508	dehydrogenase complex catalyzes the overall conversion of
L1A12_RS05490	COG0022	dehydrogenase e1 component
L1A12_RS05495	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L1A12_RS05500	COG0534	Mate efflux family protein
L1A12_RS05510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L1A12_RS05515	COG1051	belongs to the nudix hydrolase family
L1A12_RS05530	COG1011	Hydrolase
L1A12_RS05535	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
L1A12_RS05550	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L1A12_RS05555	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L1A12_RS05560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L1A12_RS05565	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L1A12_RS05595	COG3711	transcriptional antiterminator
L1A12_RS05600	COG3684	Belongs to the aldolase LacD family
L1A12_RS05650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L1A12_RS05655	COG0497	DNA recombination
L1A12_RS05660	COG1438	arginine binding
L1A12_RS05665	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
L1A12_RS05695	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L1A12_RS05715	COG3764	Sortase (surface protein transpeptidase)
L1A12_RS05720	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L1A12_RS05730	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L1A12_RS05745	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L1A12_RS05750	COG5002	protein histidine kinase activity
L1A12_RS05755	COG0745	RESPONSE REGULATOR receiver
L1A12_RS05760	COG1194	a g-specific adenine glycosylase
L1A12_RS05775	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L1A12_RS05780	COG4684	Psort location CytoplasmicMembrane, score
L1A12_RS05790	COG1827	regulation of RNA biosynthetic process
L1A12_RS05820	COG0765	amino acid transport
L1A12_RS05825	COG1126	abc transporter atp-binding protein
L1A12_RS05830	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L1A12_RS05835	COG0552	protein localization to endoplasmic reticulum
L1A12_RS05840	COG0561	phosphatase activity
L1A12_RS05845	COG0561	phosphatase activity
L1A12_RS05850	COG1196	nuclear chromosome segregation
L1A12_RS05875	COG1401	restriction endodeoxyribonuclease activity
L1A12_RS05885	COG0066	3-isopropylmalate dehydratase activity
L1A12_RS05915	COG3142	Participates in the control of copper homeostasis
L1A12_RS05920	COG2832	Protein of unknown function (DUF454)
L1A12_RS05925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L1A12_RS05935	COG0758	DNA mediated transformation
L1A12_RS05940	COG4750	Nucleotidyl transferase
L1A12_RS05955	COG1063	alcohol dehydrogenase
L1A12_RS05970	COG3475	LICD family
L1A12_RS05975	COG3475	LICD family
L1A12_RS05985	COG0505	Belongs to the CarA family
L1A12_RS06000	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L1A12_RS06015	COG0488	(ABC) transporter
L1A12_RS06025	COG1704	LemA family
L1A12_RS06040	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L1A12_RS06055	COG1078	dGTPase activity
L1A12_RS06075	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L1A12_RS06080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L1A12_RS06085	COG1605	Chorismate mutase
L1A12_RS06085	COG0077	Prephenate dehydratase
L1A12_RS06090	COG0716	FMN binding
L1A12_RS06095	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L1A12_RS06115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L1A12_RS06160	COG0577	efflux transmembrane transporter activity
L1A12_RS06160	COG1136	(ABC) transporter
L1A12_RS06170	COG0515	serine threonine protein kinase
L1A12_RS06220	COG0402	S-adenosylhomocysteine deaminase activity
L1A12_RS06230	COG1132	(ABC) transporter
L1A12_RS06235	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L1A12_RS06235	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L1A12_RS06265	COG1215	transferase activity, transferring glycosyl groups
L1A12_RS06275	COG3475	LICD family
L1A12_RS06285	COG0077	Prephenate dehydratase
L1A12_RS06290	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L1A12_RS06305	COG0287	Prephenate dehydrogenase
L1A12_RS06330	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L1A12_RS06340	COG1131	(ABC) transporter
L1A12_RS06380	COG3842	ATPase activity
L1A12_RS06395	COG3527	Alpha-acetolactate decarboxylase
L1A12_RS06400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L1A12_RS06405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1A12_RS06410	COG0704	Plays a role in the regulation of phosphate uptake
L1A12_RS06415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L1A12_RS06420	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L1A12_RS06425	COG0581	inorganic phosphate transmembrane transporter activity
L1A12_RS06430	COG0573	inorganic phosphate transmembrane transporter activity
L1A12_RS06435	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L1A12_RS06440	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L1A12_RS06440	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
L1A12_RS06445	COG0483	inositol monophosphate 1-phosphatase activity
L1A12_RS06455	COG1393	Belongs to the ArsC family
L1A12_RS06465	COG0647	UMP catabolic process
L1A12_RS06475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L1A12_RS06510	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
L1A12_RS06525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L1A12_RS06535	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
L1A12_RS06580	COG0826	peptidase U32
L1A12_RS06600	COG1132	(ABC) transporter
L1A12_RS06605	COG1132	(ABC) transporter
L1A12_RS06620	COG1129	ABC transporter
L1A12_RS06655	COG2188	Transcriptional regulator
L1A12_RS06665	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L1A12_RS06680	COG0561	phosphatase activity
L1A12_RS06700	COG0492	ferredoxin-NADP+ reductase activity
L1A12_RS06710	COG1126	abc transporter atp-binding protein
L1A12_RS06720	COG1393	Belongs to the ArsC family
L1A12_RS06725	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L1A12_RS06740	COG1272	protein, Hemolysin III
L1A12_RS06770	COG3976	FMN-binding domain protein
L1A12_RS06770	COG1053	succinate dehydrogenase
L1A12_RS06770	COG0431	NADPH-dependent FMN reductase
L1A12_RS06780	COG0751	glycine-tRNA ligase activity
L1A12_RS06795	COG0656	L-ascorbic acid biosynthetic process
L1A12_RS06800	COG0726	polysaccharide deacetylase
L1A12_RS06840	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L1A12_RS06875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L1A12_RS06885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1A12_RS06890	COG1126	abc transporter atp-binding protein
L1A12_RS06905	COG0628	permease
L1A12_RS06910	COG2706	6-phosphogluconolactonase activity
L1A12_RS06925	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L1A12_RS06970	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L1A12_RS06995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L1A12_RS07000	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
L1A12_RS07005	COG0626	cystathionine gamma-synthase activity
L1A12_RS07010	COG1132	(ABC) transporter
L1A12_RS07015	COG1132	(ABC) transporter
L1A12_RS07025	COG4166	transmembrane transport
L1A12_RS07030	COG2244	polysaccharide biosynthetic process
L1A12_RS07035	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L1A12_RS07060	COG2827	Endonuclease containing a URI domain
L1A12_RS07065	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
L1A12_RS07070	COG1098	S1 RNA binding domain
L1A12_RS07080	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L1A12_RS07085	COG0629	single-stranded DNA binding
L1A12_RS07095	COG0017	Asparaginyl-tRNA synthetase
L1A12_RS07105	COG0436	Aminotransferase
L1A12_RS07135	COG0242	peptide deformylase activity
L1A12_RS07140	COG0625	glutathione transferase activity
L1A12_RS07150	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
L1A12_RS07155	COG0488	(ABC) transporter
L1A12_RS07160	COG0617	tRNA 3'-terminal CCA addition
L1A12_RS07170	COG1307	EDD domain protein, DegV family
L1A12_RS07190	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
L1A12_RS07200	COG1481	regulation of sporulation
L1A12_RS07205	COG0391	Required for morphogenesis under gluconeogenic growth conditions
L1A12_RS07215	COG0251	oxidation-reduction process
L1A12_RS07235	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L1A12_RS07255	COG3935	DnaD domain protein
L1A12_RS07270	COG2226	methyltransferase
L1A12_RS07280	COG3842	ATPase activity
L1A12_RS07290	COG1335	isochorismatase
L1A12_RS07300	COG0513	Belongs to the DEAD box helicase family
L1A12_RS07305	COG2223	nitrite transmembrane transporter activity
L1A12_RS07310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L1A12_RS07315	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L1A12_RS07320	COG3442	glutamine amidotransferase
L1A12_RS07325	COG0006	proline dipeptidase activity
L1A12_RS07340	COG4720	Psort location CytoplasmicMembrane, score
L1A12_RS07345	COG0351	phosphomethylpyrimidine kinase
L1A12_RS07365	COG2824	Alkylphosphonate utilization operon protein PhnA
L1A12_RS07385	COG0463	Glycosyl transferase, family 2
L1A12_RS07390	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L1A12_RS07400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L1A12_RS07405	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L1A12_RS07410	COG2384	SAM-dependent methyltransferase
L1A12_RS07430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L1A12_RS07435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L1A12_RS07440	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L1A12_RS07440	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L1A12_RS07440	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L1A12_RS07445	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L1A12_RS07465	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L1A12_RS07470	COG0204	Acyl-transferase
L1A12_RS07485	COG2910	NAD(P)H-binding
L1A12_RS07510	COG5002	protein histidine kinase activity
L1A12_RS07515	COG0745	RESPONSE REGULATOR receiver
L1A12_RS07530	COG1959	2 iron, 2 sulfur cluster binding
L1A12_RS07570	COG3590	peptidase
L1A12_RS07590	COG0803	Belongs to the bacterial solute-binding protein 9 family
L1A12_RS07595	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
L1A12_RS07605	COG1136	(ABC) transporter
L1A12_RS07605	COG0577	efflux transmembrane transporter activity
L1A12_RS07655	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
L1A12_RS07675	COG1051	belongs to the nudix hydrolase family
L1A12_RS07680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L1A12_RS07695	COG0768	penicillin binding
L1A12_RS07710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L1A12_RS07725	COG2731	YhcH YjgK YiaL family protein
L1A12_RS07730	COG0395	ABC-type sugar transport system, permease component
L1A12_RS07735	COG1175	transmembrane transport
L1A12_RS07745	COG2190	(PTS) system
L1A12_RS07745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L1A12_RS07745	COG1263	PTS System
L1A12_RS07755	COG0673	inositol 2-dehydrogenase activity
L1A12_RS07760	COG4409	exo-alpha-(2->6)-sialidase activity
L1A12_RS07770	COG1175	transmembrane transport
L1A12_RS07775	COG1653	transport
L1A12_RS07795	COG3458	cephalosporin-C deacetylase activity
L1A12_RS07800	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L1A12_RS07815	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L1A12_RS07820	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L1A12_RS07835	COG1131	(ABC) transporter
L1A12_RS07865	COG0778	Nitroreductase
L1A12_RS07870	COG1484	DNA-dependent DNA replication
L1A12_RS07885	COG1725	Transcriptional regulator
L1A12_RS07890	COG1131	(ABC) transporter
L1A12_RS07900	COG1668	transmembrane transport
L1A12_RS07905	COG4152	abc transporter atp-binding protein
L1A12_RS07925	COG1940	carbohydrate kinase activity
L1A12_RS07930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L1A12_RS07930	COG2190	(PTS) system
L1A12_RS07930	COG1263	PTS System
L1A12_RS07935	COG1621	beta-fructofuranosidase activity
L1A12_RS07940	COG1609	Transcriptional regulator
L1A12_RS07950	COG3425	synthase
L1A12_RS07975	COG0515	serine threonine protein kinase
L1A12_RS07975	COG2815	serine threonine protein kinase
L1A12_RS07980	COG0631	protein serine/threonine phosphatase activity
L1A12_RS07985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L1A12_RS07985	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L1A12_RS07995	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L1A12_RS08005	COG0194	GDP metabolic process
L1A12_RS08020	COG1323	Belongs to the UPF0348 family
L1A12_RS08025	COG2226	methyltransferase
L1A12_RS08030	COG0799	negative regulation of ribosome biogenesis
L1A12_RS08040	COG1713	HD superfamily hydrolase involved in NAD metabolism
L1A12_RS08045	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L1A12_RS08050	COG1534	Rna-binding protein
L1A12_RS08055	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
L1A12_RS08070	COG0668	transmembrane transport
L1A12_RS08095	COG3118	belongs to the thioredoxin family
L1A12_RS08100	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
L1A12_RS08110	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L1A12_RS08120	COG1164	Oligoendopeptidase f
L1A12_RS08125	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L1A12_RS08130	COG2264	protein methyltransferase activity
L1A12_RS08135	COG1051	belongs to the nudix hydrolase family
L1A12_RS08170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L1A12_RS08180	COG1621	beta-fructofuranosidase activity
L1A12_RS08185	COG1653	transport
L1A12_RS08190	COG0395	ABC-type sugar transport system, permease component
L1A12_RS08195	COG4209	transmembrane transport
L1A12_RS08205	COG3711	transcriptional antiterminator
L1A12_RS08210	COG2261	transglycosylase associated protein
L1A12_RS08230	COG3237	CsbD-like
L1A12_RS08245	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L1A12_RS08275	COG0135	phosphoribosylanthranilate isomerase activity
L1A12_RS08290	COG0512	Glutamine amidotransferase of anthranilate synthase
L1A12_RS08295	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L1A12_RS08315	COG1285	pathogenesis
L1A12_RS08320	COG1178	ABC-type Fe3 transport system permease component
L1A12_RS08350	COG5434	Belongs to the glycosyl hydrolase 28 family
L1A12_RS08355	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L1A12_RS08360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L1A12_RS08365	COG1132	(ABC) transporter
L1A12_RS08370	COG1132	(ABC) transporter
L1A12_RS08385	COG0708	Exodeoxyribonuclease III
L1A12_RS08405	COG2233	PERMEase
L1A12_RS08430	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
L1A12_RS08435	COG1609	Transcriptional regulator
L1A12_RS08440	COG1063	alcohol dehydrogenase
L1A12_RS08445	COG0789	Transcriptional regulator
L1A12_RS08450	COG1230	cation diffusion facilitator family transporter
L1A12_RS08460	COG3201	nicotinamide mononucleotide transporter
L1A12_RS08465	COG1174	glycine betaine transport
L1A12_RS08490	COG1363	Peptidase, m42
L1A12_RS08495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L1A12_RS08500	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L1A12_RS08505	COG4605	iron ion homeostasis
L1A12_RS08510	COG4604	ABC transporter, ATP-binding protein
L1A12_RS08515	COG4607	ABC-type enterochelin transport system periplasmic component
L1A12_RS08525	COG1187	pseudouridine synthase activity
L1A12_RS08545	COG0517	IMP dehydrogenase activity
L1A12_RS08555	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
L1A12_RS08570	COG0366	Alpha amylase catalytic
L1A12_RS08575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L1A12_RS08575	COG1263	PTS System
L1A12_RS08580	COG2188	Transcriptional regulator
L1A12_RS08590	COG4608	Belongs to the ABC transporter superfamily
L1A12_RS08595	COG0444	Belongs to the ABC transporter superfamily
L1A12_RS08600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L1A12_RS08605	COG0601	transmembrane transport
L1A12_RS08610	COG4166	transmembrane transport
L1A12_RS08625	COG0395	ABC-type sugar transport system, permease component
L1A12_RS08630	COG1175	transmembrane transport
L1A12_RS08635	COG1653	transport
L1A12_RS08640	COG3345	alpha-galactosidase
L1A12_RS08645	COG2207	Transcriptional regulator
L1A12_RS08650	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
L1A12_RS08650	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
L1A12_RS08770	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L1A12_RS08820	COG4221	oxidoreductase activity
L1A12_RS08825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L1A12_RS08830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L1A12_RS08915	COG3842	ATPase activity
L1A12_RS08920	COG1178	ABC-type Fe3 transport system permease component
L1A12_RS08925	COG1285	pathogenesis
L1A12_RS08980	COG5632	N-Acetylmuramoyl-L-alanine amidase
L1A12_RS08980	COG5263	repeat protein
L1A12_RS09000	COG1316	TRANSCRIPTIONal
L1A12_RS09010	COG0802	atpase or kinase
L1A12_RS09035	COG1136	(ABC) transporter
L1A12_RS09060	COG1253	flavin adenine dinucleotide binding
L1A12_RS09075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L1A12_RS09085	COG3480	Lon protease (S16) C-terminal proteolytic domain
L1A12_RS09095	COG0742	ribosomal rna small subunit methyltransferase
L1A12_RS09110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L1A12_RS09115	COG1254	Belongs to the acylphosphatase family
L1A12_RS09125	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L1A12_RS09135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L1A12_RS09150	COG1564	THIamine pyrophosphokinase
L1A12_RS09160	COG1162	GTPase activity
L1A12_RS09165	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L1A12_RS09190	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
L1A12_RS09195	COG0084	hydrolase, TatD family'
L1A12_RS09215	COG0436	Aminotransferase
L1A12_RS09225	COG0589	response to stress
L1A12_RS09230	COG0561	phosphatase activity
L1A12_RS09235	COG0252	asparaginase activity
L1A12_RS09245	COG1609	Transcriptional regulator
L1A12_RS09250	COG2197	response regulator
L1A12_RS09255	COG4585	Histidine kinase
L1A12_RS09260	COG0842	Transport permease protein
L1A12_RS09265	COG1131	(ABC) transporter
L1A12_RS09370	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L1A12_RS09375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L1A12_RS09400	COG0157	Belongs to the NadC ModD family
L1A12_RS09415	COG1129	ABC transporter
L1A12_RS09420	COG2188	Transcriptional regulator
L1A12_RS09425	COG2723	6-phospho-beta-galactosidase activity
L1A12_RS09430	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L1A12_RS09440	COG1447	Phosphotransferase system cellobiose-specific component IIA
L1A12_RS09445	COG1454	alcohol dehydrogenase
L1A12_RS09445	COG1012	belongs to the aldehyde dehydrogenase family
L1A12_RS09455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L1A12_RS09465	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L1A12_RS09485	COG3623	hexulose-6-phosphate isomerase
L1A12_RS09495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L1A12_RS09505	COG3037	sugar-specific permease SgaT UlaA
L1A12_RS09515	COG1847	R3H domain protein
L1A12_RS09520	COG0706	membrane insertase activity
L1A12_RS09565	COG4537	Required for transformation and DNA binding
L1A12_RS09570	COG1459	type II secretion system
L1A12_RS09575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L1A12_RS09585	COG1063	alcohol dehydrogenase
L1A12_RS09615	COG3759	membrane
L1A12_RS09630	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L1A12_RS09630	COG0131	Imidazoleglycerol-phosphate dehydratase
L1A12_RS09635	COG0534	Mate efflux family protein
L1A12_RS09750	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L1A12_RS09755	COG1132	(ABC) transporter
L1A12_RS09765	COG1132	(ABC) transporter
L1A12_RS09775	COG1438	arginine binding
L1A12_RS09795	COG0745	RESPONSE REGULATOR receiver
L1A12_RS09800	COG5002	protein histidine kinase activity
L1A12_RS09805	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L1A12_RS09810	COG0573	inorganic phosphate transmembrane transporter activity
L1A12_RS09820	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L1A12_RS09825	COG0704	Plays a role in the regulation of phosphate uptake
L1A12_RS09845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L1A12_RS09855	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L1A12_RS09870	COG0697	spore germination
L1A12_RS09875	COG4499	WXG100 protein secretion system (Wss), protein YukC
L1A12_RS09875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L1A12_RS09885	COG2217	Heavy metal translocating P-type atpase
L1A12_RS09895	COG2226	methyltransferase
L1A12_RS09910	COG0058	SHG alpha-glucan phosphorylase activity
L1A12_RS09915	COG1640	4-alpha-glucanotransferase
L1A12_RS09920	COG2182	Extracellular solute-binding protein
L1A12_RS09925	COG1175	transmembrane transport
L1A12_RS09930	COG3833	ABC-type maltose transport systems, permease component
L1A12_RS09935	COG5521	maltodextrose utilization protein MalA
L1A12_RS09940	COG1609	Transcriptional regulator
L1A12_RS09950	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L1A12_RS09985	COG1476	TRANSCRIPTIONal
L1A12_RS10015	COG2151	metal-sulfur cluster biosynthetic enzyme
L1A12_RS10030	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L1A12_RS10035	COG3959	Transketolase, thiamine diphosphate binding domain
L1A12_RS10050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L1A12_RS10070	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L1A12_RS10085	COG0383	alpha-mannosidase activity
L1A12_RS10095	COG3537	Alpha-1,2-mannosidase
L1A12_RS10115	COG0549	Belongs to the carbamate kinase family
L1A12_RS10120	COG1288	antiporter activity
L1A12_RS10125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L1A12_RS10135	COG3583	domain protein
L1A12_RS10135	COG3525	Glycosyl hydrolase, family 20, catalytic domain
L1A12_RS10135	COG3064	Membrane
L1A12_RS10145	COG1454	alcohol dehydrogenase
L1A12_RS10150	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
L1A12_RS10165	COG3716	PTS system mannose fructose sorbose family IID component
L1A12_RS10175	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L1A12_RS10195	COG1070	Carbohydrate kinase
L1A12_RS10205	COG3443	Belongs to the bacterial solute-binding protein 9 family
L1A12_RS10205	COG0803	Belongs to the bacterial solute-binding protein 9 family
L1A12_RS10210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L1A12_RS10215	COG1121	(ABC) transporter
L1A12_RS10220	COG1846	Transcriptional regulator
L1A12_RS10225	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
L1A12_RS10235	COG1696	Membrane protein involved in D-alanine export
L1A12_RS10255	COG3344	reverse transcriptase
L1A12_RS10270	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L1A12_RS10275	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L1A12_RS10295	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L1A12_RS10300	COG0366	Alpha amylase catalytic
L1A12_RS10310	COG1755	Isoprenylcysteine carboxyl methyltransferase
L1A12_RS10315	COG5002	protein histidine kinase activity
L1A12_RS10320	COG0745	RESPONSE REGULATOR receiver
L1A12_RS10325	COG0542	response to heat
L1A12_RS10330	COG4463	regulation of RNA biosynthetic process
L1A12_RS10335	COG1116	anion transmembrane transporter activity
L1A12_RS10340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L1A12_RS10345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L1A12_RS10365	COG0305	Participates in initiation and elongation during chromosome replication
L1A12_RS10385	COG1040	competence protein
L1A12_RS10390	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
L1A12_RS10395	COG1739	Uncharacterized protein family UPF0029
L1A12_RS10430	COG3942	CHAP domain
L1A12_RS10440	COG1792	Involved in formation and maintenance of cell shape
L1A12_RS10445	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
L1A12_RS10450	COG1122	ATPase activity
L1A12_RS10455	COG1122	ATPase activity
L1A12_RS10460	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L1A12_RS10470	COG0612	Peptidase, M16
L1A12_RS10475	COG0612	Peptidase, M16
L1A12_RS10480	COG2501	S4 domain
L1A12_RS10490	COG0516	GMP reductase activity
L1A12_RS10490	COG0517	IMP dehydrogenase activity
L1A12_RS10495	COG0180	Tryptophanyl-tRNA synthetase
L1A12_RS10500	COG0488	(ABC) transporter
L1A12_RS10510	COG1511	domain protein
L1A12_RS10520	COG1511	domain protein
L1A12_RS10565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L1A12_RS10570	COG1475	DNA binding