locus-tag	class	description
SPD_RS00010	COG0592	DNA-directed DNA polymerase activity
SPD_RS00020	COG0012	GTP binding
SPD_RS00025	COG0193	aminoacyl-tRNA hydrolase activity
SPD_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPD_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPD_RS00050	COG0037	tRNA processing
SPD_RS00055	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SPD_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPD_RS00130	COG0756	dUTP diphosphatase activity
SPD_RS00140	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SPD_RS00155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPD_RS00180	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPD_RS00180	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPD_RS00185	COG1832	CoA-binding protein
SPD_RS00190	COG2855	membrane
SPD_RS00195	COG0436	Aminotransferase
SPD_RS00200	COG1381	Involved in DNA repair and RecF pathway recombination
SPD_RS00210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPD_RS00235	COG2274	protein secretion by the type I secretion system
SPD_RS00240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPD_RS00245	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SPD_RS00255	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPD_RS00260	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SPD_RS00265	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SPD_RS00270	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPD_RS00280	COG0138	bifunctional purine biosynthesis protein purh
SPD_RS00285	COG0151	Belongs to the GarS family
SPD_RS00300	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPD_RS00315	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPD_RS00320	COG3583	domain protein
SPD_RS00320	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPD_RS00320	COG3064	Membrane
SPD_RS00335	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPD_RS00340	COG3715	PTS system
SPD_RS00345	COG3716	PTS system mannose fructose sorbose family IID component
SPD_RS00355	COG2222	sugar isomerase
SPD_RS00365	COG2514	catechol 2,3-dioxygenase activity
SPD_RS00370	COG1937	Protein conserved in bacteria
SPD_RS00410	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPD_RS00415	COG0569	domain protein
SPD_RS00420	COG1215	transferase activity, transferring glycosyl groups
SPD_RS00440	COG5002	protein histidine kinase activity
SPD_RS00470	COG4209	transmembrane transport
SPD_RS00475	COG0395	ABC-type sugar transport system, permease component
SPD_RS00485	COG1653	transport
SPD_RS00515	COG1695	Transcriptional regulator
SPD_RS00540	COG0546	phosphoglycolate phosphatase activity
SPD_RS00545	COG1760	l-serine dehydratase
SPD_RS00550	COG1760	l-serine dehydratase
SPD_RS00580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPD_RS00585	COG0137	argininosuccinate synthase activity
SPD_RS00605	COG2274	protein secretion by the type I secretion system
SPD_RS00700	COG0482	sulfurtransferase activity
SPD_RS00705	COG0494	nUDIX hydrolase
SPD_RS00710	COG0445	tRNA wobble uridine modification
SPD_RS00745	COG1214	PFAM Peptidase M22, glycoprotease
SPD_RS00755	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SPD_RS00775	COG0438	transferase activity, transferring glycosyl groups
SPD_RS00810	COG1396	sequence-specific DNA binding
SPD_RS00840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPD_RS00845	COG1464	Belongs to the NlpA lipoprotein family
SPD_RS00850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPD_RS00855	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPD_RS00875	COG2972	Histidine kinase
SPD_RS00880	COG4753	response regulator
SPD_RS00880	COG2207	Transcriptional regulator
SPD_RS00890	COG1780	Probably involved in ribonucleotide reductase function
SPD_RS00930	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPD_RS00930	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPD_RS00950	COG2818	Glycosylase
SPD_RS00975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPD_RS00980	COG0006	proline dipeptidase activity
SPD_RS00990	COG1393	Belongs to the ArsC family
SPD_RS01015	COG0285	dihydrofolate synthase activity
SPD_RS01025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPD_RS01055	COG0602	queuosine metabolic process
SPD_RS01090	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPD_RS01115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SPD_RS01155	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SPD_RS01170	COG0201	protein transport
SPD_RS01180	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SPD_RS01185	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SPD_RS01195	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SPD_RS01200	COG0202	RNA polymerase activity
SPD_RS01210	COG3830	Belongs to the UPF0237 family
SPD_RS01230	COG1178	ABC-type Fe3 transport system permease component
SPD_RS01235	COG3842	ATPase activity
SPD_RS01250	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPD_RS01255	COG1349	DNA-binding transcription factor activity
SPD_RS01265	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPD_RS01270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPD_RS01275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPD_RS01280	COG1882	Formate acetyltransferase
SPD_RS01295	COG0495	leucyl-tRNA aminoacylation
SPD_RS01325	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPD_RS01330	COG4589	Belongs to the CDS family
SPD_RS01335	COG0750	zinc metalloprotease
SPD_RS01340	COG0442	prolyl-tRNA aminoacylation
SPD_RS01345	COG2723	6-phospho-beta-galactosidase activity
SPD_RS01350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPD_RS01360	COG1523	belongs to the glycosyl hydrolase 13 family
SPD_RS01385	COG2176	DNA-directed DNA polymerase activity
SPD_RS01405	COG2309	aminopeptidase activity
SPD_RS01410	COG2261	transglycosylase associated protein
SPD_RS01415	COG1187	pseudouridine synthase activity
SPD_RS01425	COG3579	cysteine-type endopeptidase activity
SPD_RS01430	COG3716	PTS system mannose fructose sorbose family IID component
SPD_RS01435	COG3715	PTS system
SPD_RS01445	COG1064	alcohol dehydrogenase
SPD_RS01450	COG0561	phosphatase activity
SPD_RS01455	COG2252	PERMEase
SPD_RS01465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SPD_RS01470	COG0285	dihydrofolate synthase activity
SPD_RS01475	COG0302	gtp cyclohydrolase
SPD_RS01480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SPD_RS01480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPD_RS01490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPD_RS01515	COG2723	6-phospho-beta-galactosidase activity
SPD_RS01530	COG3711	transcriptional antiterminator
SPD_RS01530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPD_RS01545	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPD_RS01565	COG0386	Belongs to the glutathione peroxidase family
SPD_RS01570	COG5492	domain, Protein
SPD_RS01605	COG1028	Short-chain dehydrogenase reductase Sdr
SPD_RS01615	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SPD_RS01620	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPD_RS01625	COG3715	PTS system
SPD_RS01630	COG3716	PTS system mannose fructose sorbose family IID component
SPD_RS01645	COG1609	Transcriptional regulator
SPD_RS01670	COG4839	cell division protein FtsL
SPD_RS01675	COG0768	penicillin binding
SPD_RS01680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPD_RS01695	COG4868	Belongs to the UPF0371 family
SPD_RS01700	COG0366	Alpha amylase catalytic
SPD_RS01705	COG4166	transmembrane transport
SPD_RS01720	COG4464	protein tyrosine phosphatase activity
SPD_RS01725	COG3944	biosynthesis protein
SPD_RS01730	COG0489	protein tyrosine kinase activity
SPD_RS01770	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SPD_RS01775	COG0562	UDP-galactopyranose mutase
SPD_RS01780	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SPD_RS01790	COG1088	dTDP-glucose 4,6-dehydratase activity
SPD_RS01795	COG1091	dTDP-4-dehydrorhamnose reductase activity
SPD_RS01805	COG4372	Transposase
SPD_RS01815	COG4166	transmembrane transport
SPD_RS01825	COG0366	Alpha amylase catalytic
SPD_RS01830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPD_RS01855	COG0116	Belongs to the methyltransferase superfamily
SPD_RS01865	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SPD_RS01870	COG0745	RESPONSE REGULATOR receiver
SPD_RS01895	COG1304	FMN binding
SPD_RS01905	COG4585	Histidine kinase
SPD_RS01910	COG2197	response regulator
SPD_RS01950	COG2213	PTS system mannitol-specific
SPD_RS01955	COG3711	transcriptional antiterminator
SPD_RS01960	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPD_RS01965	COG0246	Mannitol dehydrogenase
SPD_RS01975	COG0544	peptidyl-prolyl cis-trans isomerase activity
SPD_RS01980	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPD_RS01985	COG0681	Belongs to the peptidase S26 family
SPD_RS02005	COG1193	negative regulation of DNA recombination
SPD_RS02010	COG1115	amino acid carrier protein
SPD_RS02025	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SPD_RS02035	COG0527	aspartate kinase activity
SPD_RS02045	COG1024	Enoyl-CoA hydratase
SPD_RS02050	COG1846	Transcriptional regulator
SPD_RS02060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPD_RS02070	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPD_RS02075	COG1028	Short-chain dehydrogenase reductase Sdr
SPD_RS02080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPD_RS02095	COG0439	Biotin carboxylase
SPD_RS02100	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPD_RS02145	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SPD_RS02165	COG1442	glycosyl transferase family 8
SPD_RS02170	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SPD_RS02180	COG1461	Dihydroxyacetone kinase
SPD_RS02185	COG0028	Belongs to the TPP enzyme family
SPD_RS02190	COG0440	acetolactate synthase activity
SPD_RS02210	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SPD_RS02230	COG0765	amino acid transport
SPD_RS02250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPD_RS02255	COG1882	Formate acetyltransferase
SPD_RS02285	COG1940	carbohydrate kinase activity
SPD_RS02285	COG1846	Transcriptional regulator
SPD_RS02290	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPD_RS02300	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPD_RS02305	COG2723	6-phospho-beta-galactosidase activity
SPD_RS02310	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPD_RS02310	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPD_RS02315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPD_RS02320	COG0569	domain protein
SPD_RS02335	COG1122	ATPase activity
SPD_RS02350	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPD_RS02355	COG0671	phosphoesterase, PA-phosphatase related
SPD_RS02365	COG1247	-acetyltransferase
SPD_RS02375	COG0504	CTP synthase activity
SPD_RS02380	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPD_RS02390	COG0126	phosphoglycerate kinase activity
SPD_RS02400	COG0789	Transcriptional regulator
SPD_RS02405	COG0174	glutamine synthetase
SPD_RS02425	COG0732	type I restriction modification DNA specificity domain
SPD_RS02435	COG4974	Belongs to the 'phage' integrase family
SPD_RS02470	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SPD_RS02485	COG0484	heat shock protein binding
SPD_RS02495	COG0537	adenosine 5'-monophosphoramidase activity
SPD_RS02500	COG1131	(ABC) transporter
SPD_RS02525	COG3290	protein histidine kinase activity
SPD_RS02565	COG1266	CAAX protease self-immunity
SPD_RS02585	COG0195	Participates in both transcription termination and antitermination
SPD_RS02590	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPD_RS02605	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SPD_RS02650	COG0519	Catalyzes the synthesis of GMP from XMP
SPD_RS02660	COG0525	valine-tRNA ligase activity
SPD_RS02695	COG3711	transcriptional antiterminator
SPD_RS02700	COG2190	(PTS) system
SPD_RS02700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPD_RS02700	COG1263	PTS System
SPD_RS02715	COG0456	acetyltransferase
SPD_RS02720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPD_RS02720	COG0072	phenylalanine-tRNA ligase activity
SPD_RS02735	COG3620	sequence-specific DNA binding
SPD_RS02740	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SPD_RS02755	COG1185	polyribonucleotide nucleotidyltransferase activity
SPD_RS02760	COG1045	serine acetyltransferase
SPD_RS02775	COG0215	cysteine-tRNA ligase activity
SPD_RS02780	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPD_RS02795	COG0577	efflux transmembrane transporter activity
SPD_RS02800	COG1136	(ABC) transporter
SPD_RS02805	COG0577	efflux transmembrane transporter activity
SPD_RS02810	COG0745	RESPONSE REGULATOR receiver
SPD_RS02815	COG5002	protein histidine kinase activity
SPD_RS02820	COG0191	fructose-bisphosphate aldolase activity
SPD_RS02825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SPD_RS02835	COG0765	amino acid transport
SPD_RS02840	COG0765	amino acid transport
SPD_RS02845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPD_RS02855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPD_RS02855	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPD_RS02885	COG0322	excinuclease ABC activity
SPD_RS02895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPD_RS02910	COG1573	uracil-dna glycosylase
SPD_RS02925	COG1114	Component of the transport system for branched-chain amino acids
SPD_RS02930	COG1363	Peptidase, m42
SPD_RS02970	COG4555	ABC transporter
SPD_RS03010	COG1404	Belongs to the peptidase S8 family
SPD_RS03025	COG3775	system Galactitol-specific IIC component
SPD_RS03035	COG3250	beta-galactosidase activity
SPD_RS03065	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPD_RS03085	COG0785	Cytochrome C biogenesis protein
SPD_RS03090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPD_RS03095	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPD_RS03095	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPD_RS03105	COG4753	response regulator
SPD_RS03105	COG2207	Transcriptional regulator
SPD_RS03110	COG2972	Histidine kinase
SPD_RS03115	COG4475	Protein of unknown function (DUF436)
SPD_RS03120	COG3064	Membrane
SPD_RS03125	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPD_RS03140	COG1940	carbohydrate kinase activity
SPD_RS03155	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SPD_RS03160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPD_RS03165	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPD_RS03175	COG0300	oxidoreductase activity
SPD_RS03190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPD_RS03200	COG1187	pseudouridine synthase activity
SPD_RS03205	COG1217	gtp-binding protein TYPA
SPD_RS03225	COG1136	(ABC) transporter
SPD_RS03230	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SPD_RS03235	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SPD_RS03240	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SPD_RS03280	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SPD_RS03305	COG1131	(ABC) transporter
SPD_RS03315	COG1126	abc transporter atp-binding protein
SPD_RS03320	COG0765	amino acid transport
SPD_RS03330	COG1304	FMN binding
SPD_RS03345	COG1304	FMN binding
SPD_RS03360	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SPD_RS03365	COG0352	thiamine-phosphate diphosphorylase activity
SPD_RS03380	COG4172	Belongs to the ABC transporter superfamily
SPD_RS03390	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SPD_RS03400	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SPD_RS03405	COG0352	thiamine-phosphate diphosphorylase activity
SPD_RS03425	COG2217	Heavy metal translocating P-type atpase
SPD_RS03430	COG0028	Belongs to the TPP enzyme family
SPD_RS03445	COG2723	6-phospho-beta-galactosidase activity
SPD_RS03450	COG1482	cell wall glycoprotein biosynthetic process
SPD_RS03455	COG0733	neurotransmitter:sodium symporter activity
SPD_RS03470	COG2081	HI0933 family
SPD_RS03475	COG1307	EDD domain protein, DegV family
SPD_RS03485	COG2131	deaminase
SPD_RS03490	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SPD_RS03535	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPD_RS03535	COG0617	tRNA 3'-terminal CCA addition
SPD_RS03535	COG0517	IMP dehydrogenase activity
SPD_RS03545	COG2884	Cell division ATP-binding protein ftsE
SPD_RS03550	COG2177	Part of the ABC transporter FtsEX involved in
SPD_RS03555	COG2190	(PTS) system
SPD_RS03555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPD_RS03555	COG1263	PTS System
SPD_RS03565	COG0513	Belongs to the DEAD box helicase family
SPD_RS03580	COG0167	dihydroorotate dehydrogenase activity
SPD_RS03590	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SPD_RS03595	COG4470	Protein conserved in bacteria
SPD_RS03600	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SPD_RS03610	COG0488	(ABC) transporter
SPD_RS03640	COG1837	Belongs to the UPF0109 family
SPD_RS03670	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPD_RS03670	COG1328	CTP reductase activity
SPD_RS03680	COG4443	Transcriptional Coactivator p15 (PC4)
SPD_RS03690	COG1268	BioY protein
SPD_RS03695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPD_RS03700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPD_RS03705	COG1136	(ABC) transporter
SPD_RS03710	COG0577	efflux transmembrane transporter activity
SPD_RS03715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPD_RS03715	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPD_RS03735	COG4989	oxidoreductase activity
SPD_RS03745	COG1028	Short-chain dehydrogenase reductase Sdr
SPD_RS03775	COG0745	RESPONSE REGULATOR receiver
SPD_RS03780	COG5002	protein histidine kinase activity
SPD_RS03800	COG0772	Belongs to the SEDS family
SPD_RS03805	COG0693	protein deglycase activity
SPD_RS03815	COG0187	DNA topoisomerase II activity
SPD_RS03850	COG0494	nUDIX hydrolase
SPD_RS03860	COG0542	response to heat
SPD_RS03865	COG4703	Protein of unknown function (DUF1797)
SPD_RS03870	COG0765	amino acid transport
SPD_RS03875	COG1126	abc transporter atp-binding protein
SPD_RS03880	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPD_RS03885	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SPD_RS03895	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SPD_RS03905	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SPD_RS03960	COG2813	Specifically methylates the guanine in position
SPD_RS03965	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SPD_RS03970	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SPD_RS03975	COG0295	cytidine deaminase activity
SPD_RS03980	COG1744	ABC transporter substrate-binding protein PnrA-like
SPD_RS03985	COG3845	ABC transporter
SPD_RS03990	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPD_RS03995	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPD_RS04010	COG0187	DNA topoisomerase II activity
SPD_RS04015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPD_RS04020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPD_RS04025	COG4166	transmembrane transport
SPD_RS04060	COG0539	negative regulation of cytoplasmic translation
SPD_RS04070	COG1956	GAF domain-containing protein
SPD_RS04075	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPD_RS04090	COG0719	Fe-S assembly protein
SPD_RS04095	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPD_RS04105	COG0719	Fe-S assembly protein
SPD_RS04110	COG1686	Belongs to the peptidase S11 family
SPD_RS04115	COG0628	permease
SPD_RS04130	COG1349	DNA-binding transcription factor activity
SPD_RS04135	COG1105	Belongs to the carbohydrate kinase PfkB family
SPD_RS04140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPD_RS04140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPD_RS04140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPD_RS04145	COG0697	spore germination
SPD_RS04145	COG1674	ftsk spoiiie
SPD_RS04155	COG1104	cysteine desulfurase activity
SPD_RS04160	COG0301	tRNA thio-modification
SPD_RS04190	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
SPD_RS04200	COG1438	arginine binding
SPD_RS04205	COG2936	dipeptidyl-peptidase activity
SPD_RS04215	COG0205	6-phosphofructokinase activity
SPD_RS04220	COG0469	pyruvate kinase activity
SPD_RS04270	COG3689	TIGRFAM TIGR03943 family protein
SPD_RS04275	COG0701	Predicted permease
SPD_RS04290	COG3955	Domain of unknown function (DUF1919)
SPD_RS04295	COG2183	response to ionizing radiation
SPD_RS04315	COG1136	(ABC) transporter
SPD_RS04320	COG0577	efflux transmembrane transporter activity
SPD_RS04340	COG1982	Orn Lys Arg decarboxylase major
SPD_RS04350	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SPD_RS04365	COG2957	Belongs to the agmatine deiminase family
SPD_RS04370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPD_RS04375	COG0561	phosphatase activity
SPD_RS04395	COG0583	DNA-binding transcription factor activity
SPD_RS04400	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPD_RS04405	COG0564	pseudouridine synthase activity
SPD_RS04410	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPD_RS04415	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SPD_RS04425	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPD_RS04430	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SPD_RS04435	COG0470	DNA polymerase III
SPD_RS04475	COG0528	UMP kinase activity
SPD_RS04480	COG0233	cytoplasmic translational termination
SPD_RS04485	COG2996	Protein conserved in bacteria
SPD_RS04495	COG1702	phosphate starvation-inducible protein PhoH
SPD_RS04515	COG0686	Belongs to the AlaDH PNT family
SPD_RS04520	COG0686	Belongs to the AlaDH PNT family
SPD_RS04525	COG0686	Belongs to the AlaDH PNT family
SPD_RS04530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPD_RS04535	COG1555	photosystem II stabilization
SPD_RS04535	COG1596	polysaccharide export
SPD_RS04540	COG2333	competence protein COMEC
SPD_RS04540	COG0658	competence protein
SPD_RS04550	COG1131	(ABC) transporter
SPD_RS04580	COG0543	2 iron, 2 sulfur cluster binding
SPD_RS04585	COG0167	dihydroorotate dehydrogenase activity
SPD_RS04590	COG5263	repeat protein
SPD_RS04590	COG4193	domain, Protein
SPD_RS04595	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPD_RS04605	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPD_RS04615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPD_RS04620	COG0237	dephospho-CoA kinase activity
SPD_RS04625	COG2814	Major facilitator Superfamily
SPD_RS04640	COG0557	exoribonuclease II activity
SPD_RS04650	COG0500	methyltransferase
SPD_RS04650	COG3615	Tellurite resistance protein tehB
SPD_RS04665	COG4122	O-methyltransferase activity
SPD_RS04695	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SPD_RS04710	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SPD_RS04715	COG0494	nUDIX hydrolase
SPD_RS04725	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPD_RS04735	COG2176	DNA-directed DNA polymerase activity
SPD_RS04740	COG0584	glycerophosphoryl diester phosphodiesterase
SPD_RS04760	COG0785	Cytochrome C biogenesis protein
SPD_RS04765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPD_RS04770	COG0531	amino acid
SPD_RS04775	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPD_RS04775	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPD_RS04810	COG2195	Cleaves the N-terminal amino acid of tripeptides
SPD_RS04815	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SPD_RS04820	COG1970	mechanosensitive ion channel activity
SPD_RS04830	COG4708	membrane
SPD_RS04840	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPD_RS04845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPD_RS04850	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SPD_RS04855	COG1942	4-Oxalocrotonate Tautomerase
SPD_RS04860	COG1435	thymidine kinase activity
SPD_RS04875	COG2890	protein-(glutamine-N5) methyltransferase activity
SPD_RS04890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SPD_RS04900	COG0741	lytic transglycosylase activity
SPD_RS04910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPD_RS04935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPD_RS04940	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPD_RS04990	COG1597	lipid kinase activity
SPD_RS04995	COG0366	Alpha amylase catalytic
SPD_RS05010	COG1396	sequence-specific DNA binding
SPD_RS05015	COG0542	response to heat
SPD_RS05040	COG3843	relaxase mobilization nuclease domain protein
SPD_RS05085	COG0318	PFAM AMP-dependent synthetase and ligase
SPD_RS05130	COG0772	Belongs to the SEDS family
SPD_RS05135	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SPD_RS05155	COG0358	DNA primase activity
SPD_RS05160	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPD_RS05165	COG2151	metal-sulfur cluster biosynthetic enzyme
SPD_RS05170	COG0438	transferase activity, transferring glycosyl groups
SPD_RS05175	COG0438	transferase activity, transferring glycosyl groups
SPD_RS05190	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SPD_RS05205	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPD_RS05215	COG4109	DRTGG domain
SPD_RS05220	COG0024	Methionine aminopeptidase
SPD_RS05235	COG0210	DNA helicase
SPD_RS05240	COG2003	Belongs to the UPF0758 family
SPD_RS05245	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPD_RS05250	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SPD_RS05265	COG1104	cysteine desulfurase activity
SPD_RS05270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPD_RS05280	COG2357	RelA SpoT domain protein
SPD_RS05290	COG0564	pseudouridine synthase activity
SPD_RS05295	COG0280	phosphate acetyltransferase
SPD_RS05335	COG0196	riboflavin kinase activity
SPD_RS05340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPD_RS05345	COG1307	EDD domain protein, DegV family
SPD_RS05355	COG0488	(ABC) transporter
SPD_RS05370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SPD_RS05375	COG1523	belongs to the glycosyl hydrolase 13 family
SPD_RS05380	COG1012	belongs to the aldehyde dehydrogenase family
SPD_RS05390	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SPD_RS05395	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SPD_RS05400	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SPD_RS05405	COG0297	glycogen (starch) synthase activity
SPD_RS05430	COG0582	viral genome integration into host DNA
SPD_RS05450	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SPD_RS05455	COG1074	ATP-dependent DNA helicase activity
SPD_RS05470	COG3583	domain protein
SPD_RS05470	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
SPD_RS05485	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPD_RS05490	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SPD_RS05505	COG0095	Lipoate-protein ligase
SPD_RS05510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPD_RS05515	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPD_RS05520	COG0022	dehydrogenase e1 component
SPD_RS05525	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPD_RS05530	COG0534	Mate efflux family protein
SPD_RS05540	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPD_RS05545	COG1051	belongs to the nudix hydrolase family
SPD_RS05560	COG1011	Hydrolase
SPD_RS05585	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPD_RS05590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPD_RS05595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPD_RS05600	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPD_RS05615	COG2723	6-phospho-beta-galactosidase activity
SPD_RS05630	COG3711	transcriptional antiterminator
SPD_RS05635	COG3684	Belongs to the aldolase LacD family
SPD_RS05685	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SPD_RS05690	COG0497	DNA recombination
SPD_RS05695	COG1438	arginine binding
SPD_RS05700	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPD_RS05715	COG1570	exodeoxyribonuclease VII activity
SPD_RS05735	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SPD_RS05760	COG3764	Sortase (surface protein transpeptidase)
SPD_RS05765	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPD_RS05795	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPD_RS05800	COG5002	protein histidine kinase activity
SPD_RS05805	COG0745	RESPONSE REGULATOR receiver
SPD_RS05810	COG1194	a g-specific adenine glycosylase
SPD_RS05830	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPD_RS05835	COG4684	Psort location CytoplasmicMembrane, score
SPD_RS05845	COG1827	regulation of RNA biosynthetic process
SPD_RS05865	COG0556	nucleotide-excision repair
SPD_RS05875	COG0765	amino acid transport
SPD_RS05880	COG1126	abc transporter atp-binding protein
SPD_RS05885	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPD_RS05890	COG0552	protein localization to endoplasmic reticulum
SPD_RS05895	COG0561	phosphatase activity
SPD_RS05900	COG0561	phosphatase activity
SPD_RS05905	COG1196	nuclear chromosome segregation
SPD_RS05930	COG1401	restriction endodeoxyribonuclease activity
SPD_RS05940	COG0066	3-isopropylmalate dehydratase activity
SPD_RS05950	COG0473	3-isopropylmalate dehydrogenase activity
SPD_RS05965	COG3142	Participates in the control of copper homeostasis
SPD_RS05970	COG2832	Protein of unknown function (DUF454)
SPD_RS05975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPD_RS05990	COG0758	DNA mediated transformation
SPD_RS05995	COG4750	Nucleotidyl transferase
SPD_RS06010	COG1063	alcohol dehydrogenase
SPD_RS06015	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SPD_RS06025	COG3475	LICD family
SPD_RS06030	COG3475	LICD family
SPD_RS06040	COG0505	Belongs to the CarA family
SPD_RS06045	COG0540	Belongs to the ATCase OTCase family
SPD_RS06055	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPD_RS06070	COG0488	(ABC) transporter
SPD_RS06080	COG1704	LemA family
SPD_RS06095	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPD_RS06110	COG1078	dGTPase activity
SPD_RS06125	COG0335	large ribosomal subunit rRNA binding
SPD_RS06130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPD_RS06135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPD_RS06140	COG1605	Chorismate mutase
SPD_RS06140	COG0077	Prephenate dehydratase
SPD_RS06145	COG0716	FMN binding
SPD_RS06150	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPD_RS06175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPD_RS06215	COG0295	cytidine deaminase activity
SPD_RS06220	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SPD_RS06235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPD_RS06240	COG0601	transmembrane transport
SPD_RS06255	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SPD_RS06290	COG0577	efflux transmembrane transporter activity
SPD_RS06290	COG1136	(ABC) transporter
SPD_RS06300	COG1770	oligopeptidase
SPD_RS06305	COG0515	serine threonine protein kinase
SPD_RS06360	COG0402	S-adenosylhomocysteine deaminase activity
SPD_RS06375	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPD_RS06375	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPD_RS06395	COG4862	establishment of competence for transformation
SPD_RS06410	COG1215	transferase activity, transferring glycosyl groups
SPD_RS06420	COG3475	LICD family
SPD_RS06430	COG0077	Prephenate dehydratase
SPD_RS06435	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SPD_RS06440	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SPD_RS06450	COG0287	Prephenate dehydrogenase
SPD_RS06475	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPD_RS06490	COG1131	(ABC) transporter
SPD_RS06500	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SPD_RS06530	COG3842	ATPase activity
SPD_RS06545	COG3527	Alpha-acetolactate decarboxylase
SPD_RS06550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPD_RS06555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPD_RS06560	COG0704	Plays a role in the regulation of phosphate uptake
SPD_RS06565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPD_RS06570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPD_RS06575	COG0581	inorganic phosphate transmembrane transporter activity
SPD_RS06580	COG0573	inorganic phosphate transmembrane transporter activity
SPD_RS06585	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPD_RS06590	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPD_RS06590	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPD_RS06595	COG0483	inositol monophosphate 1-phosphatase activity
SPD_RS06605	COG1393	Belongs to the ArsC family
SPD_RS06615	COG0647	UMP catabolic process
SPD_RS06625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPD_RS06645	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SPD_RS06660	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SPD_RS06675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPD_RS06685	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPD_RS06705	COG1131	(ABC) transporter
SPD_RS06720	COG0826	peptidase U32
SPD_RS06755	COG1132	(ABC) transporter
SPD_RS06770	COG1129	ABC transporter
SPD_RS06815	COG2188	Transcriptional regulator
SPD_RS06820	COG0697	spore germination
SPD_RS06825	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPD_RS06840	COG0561	phosphatase activity
SPD_RS06875	COG0492	ferredoxin-NADP+ reductase activity
SPD_RS06885	COG1126	abc transporter atp-binding protein
SPD_RS06895	COG1393	Belongs to the ArsC family
SPD_RS06900	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SPD_RS06915	COG1272	protein, Hemolysin III
SPD_RS06920	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SPD_RS06945	COG0431	NADPH-dependent FMN reductase
SPD_RS06945	COG1053	succinate dehydrogenase
SPD_RS06945	COG3976	FMN-binding domain protein
SPD_RS06955	COG0751	glycine-tRNA ligase activity
SPD_RS06960	COG0752	glycyl-tRNA synthetase alpha subunit
SPD_RS06970	COG0656	L-ascorbic acid biosynthetic process
SPD_RS06975	COG0726	polysaccharide deacetylase
SPD_RS07025	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPD_RS07060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPD_RS07075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPD_RS07080	COG1126	abc transporter atp-binding protein
SPD_RS07095	COG0628	permease
SPD_RS07100	COG2706	6-phosphogluconolactonase activity
SPD_RS07115	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SPD_RS07120	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SPD_RS07165	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPD_RS07190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPD_RS07195	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SPD_RS07200	COG0626	cystathionine gamma-synthase activity
SPD_RS07210	COG1132	(ABC) transporter
SPD_RS07220	COG4166	transmembrane transport
SPD_RS07225	COG2244	polysaccharide biosynthetic process
SPD_RS07230	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPD_RS07255	COG2827	Endonuclease containing a URI domain
SPD_RS07260	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPD_RS07265	COG1098	S1 RNA binding domain
SPD_RS07275	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPD_RS07280	COG0629	single-stranded DNA binding
SPD_RS07295	COG0436	Aminotransferase
SPD_RS07320	COG3711	transcriptional antiterminator
SPD_RS07345	COG0242	peptide deformylase activity
SPD_RS07350	COG0625	glutathione transferase activity
SPD_RS07360	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPD_RS07365	COG0488	(ABC) transporter
SPD_RS07370	COG0617	tRNA 3'-terminal CCA addition
SPD_RS07380	COG1307	EDD domain protein, DegV family
SPD_RS07390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPD_RS07400	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPD_RS07410	COG0492	ferredoxin-NADP+ reductase activity
SPD_RS07415	COG1481	regulation of sporulation
SPD_RS07420	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SPD_RS07425	COG1660	Displays ATPase and GTPase activities
SPD_RS07430	COG0251	oxidation-reduction process
SPD_RS07450	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPD_RS07460	COG4193	domain, Protein
SPD_RS07460	COG5263	repeat protein
SPD_RS07470	COG3935	DnaD domain protein
SPD_RS07485	COG2226	methyltransferase
SPD_RS07490	COG3842	ATPase activity
SPD_RS07500	COG1335	isochorismatase
SPD_RS07505	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SPD_RS07515	COG0513	Belongs to the DEAD box helicase family
SPD_RS07520	COG2223	nitrite transmembrane transporter activity
SPD_RS07525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPD_RS07530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPD_RS07535	COG3442	glutamine amidotransferase
SPD_RS07540	COG0006	proline dipeptidase activity
SPD_RS07555	COG4720	Psort location CytoplasmicMembrane, score
SPD_RS07560	COG0351	phosphomethylpyrimidine kinase
SPD_RS07585	COG2824	Alkylphosphonate utilization operon protein PhnA
SPD_RS07605	COG0463	Glycosyl transferase, family 2
SPD_RS07610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPD_RS07615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPD_RS07620	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SPD_RS07625	COG2384	SAM-dependent methyltransferase
SPD_RS07630	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SPD_RS07635	COG0204	Acyl-transferase
SPD_RS07650	COG2910	NAD(P)H-binding
SPD_RS07680	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SPD_RS07685	COG5002	protein histidine kinase activity
SPD_RS07690	COG0745	RESPONSE REGULATOR receiver
SPD_RS07705	COG1959	2 iron, 2 sulfur cluster binding
SPD_RS07765	COG3590	peptidase
SPD_RS07780	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPD_RS07785	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SPD_RS07795	COG0577	efflux transmembrane transporter activity
SPD_RS07795	COG1136	(ABC) transporter
SPD_RS07825	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SPD_RS07835	COG3599	regulation of cell shape
SPD_RS07855	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPD_RS07875	COG1051	belongs to the nudix hydrolase family
SPD_RS07880	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPD_RS07885	COG1181	Belongs to the D-alanine--D-alanine ligase family
SPD_RS07895	COG0768	penicillin binding
SPD_RS07930	COG2731	YhcH YjgK YiaL family protein
SPD_RS07935	COG0395	ABC-type sugar transport system, permease component
SPD_RS07940	COG1175	transmembrane transport
SPD_RS07950	COG2190	(PTS) system
SPD_RS07950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPD_RS07950	COG1263	PTS System
SPD_RS07960	COG0673	inositol 2-dehydrogenase activity
SPD_RS07965	COG4409	exo-alpha-(2->6)-sialidase activity
SPD_RS07975	COG1175	transmembrane transport
SPD_RS07980	COG1653	transport
SPD_RS08000	COG3458	cephalosporin-C deacetylase activity
SPD_RS08010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPD_RS08025	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPD_RS08030	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPD_RS08035	COG0653	protein targeting
SPD_RS08045	COG1131	(ABC) transporter
SPD_RS08090	COG1484	DNA-dependent DNA replication
SPD_RS08105	COG1725	Transcriptional regulator
SPD_RS08110	COG1131	(ABC) transporter
SPD_RS08120	COG1668	transmembrane transport
SPD_RS08125	COG4152	abc transporter atp-binding protein
SPD_RS08145	COG1940	carbohydrate kinase activity
SPD_RS08150	COG2190	(PTS) system
SPD_RS08150	COG1263	PTS System
SPD_RS08150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPD_RS08165	COG1621	beta-fructofuranosidase activity
SPD_RS08170	COG1609	Transcriptional regulator
SPD_RS08180	COG3425	synthase
SPD_RS08205	COG0515	serine threonine protein kinase
SPD_RS08205	COG2815	serine threonine protein kinase
SPD_RS08210	COG0631	protein serine/threonine phosphatase activity
SPD_RS08215	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPD_RS08215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPD_RS08225	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPD_RS08235	COG0194	GDP metabolic process
SPD_RS08245	COG4115	mRNA cleavage
SPD_RS08255	COG1323	Belongs to the UPF0348 family
SPD_RS08260	COG2226	methyltransferase
SPD_RS08265	COG0799	negative regulation of ribosome biogenesis
SPD_RS08275	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPD_RS08280	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SPD_RS08285	COG1534	Rna-binding protein
SPD_RS08290	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPD_RS08305	COG0668	transmembrane transport
SPD_RS08315	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
SPD_RS08335	COG3118	belongs to the thioredoxin family
SPD_RS08340	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SPD_RS08355	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPD_RS08365	COG1164	Oligoendopeptidase f
SPD_RS08370	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPD_RS08375	COG2264	protein methyltransferase activity
SPD_RS08380	COG1051	belongs to the nudix hydrolase family
SPD_RS08425	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPD_RS08435	COG1621	beta-fructofuranosidase activity
SPD_RS08440	COG0395	ABC-type sugar transport system, permease component
SPD_RS08445	COG1175	transmembrane transport
SPD_RS08455	COG1609	Transcriptional regulator
SPD_RS08460	COG3711	transcriptional antiterminator
SPD_RS08485	COG3237	CsbD-like
SPD_RS08520	COG0159	tryptophan synthase activity
SPD_RS08525	COG0133	tryptophan synthase activity
SPD_RS08530	COG0135	phosphoribosylanthranilate isomerase activity
SPD_RS08545	COG0512	Glutamine amidotransferase of anthranilate synthase
SPD_RS08550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPD_RS08570	COG1285	pathogenesis
SPD_RS08575	COG1178	ABC-type Fe3 transport system permease component
SPD_RS08595	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPD_RS08600	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPD_RS08605	COG0704	Plays a role in the regulation of phosphate uptake
SPD_RS08620	COG5434	Belongs to the glycosyl hydrolase 28 family
SPD_RS08630	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SPD_RS08635	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPD_RS08645	COG1132	(ABC) transporter
SPD_RS08650	COG1132	(ABC) transporter
SPD_RS08670	COG0708	Exodeoxyribonuclease III
SPD_RS08685	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPD_RS08690	COG2233	PERMEase
SPD_RS08710	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPD_RS08715	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPD_RS08720	COG1609	Transcriptional regulator
SPD_RS08725	COG1063	alcohol dehydrogenase
SPD_RS08730	COG0789	Transcriptional regulator
SPD_RS08735	COG1230	cation diffusion facilitator family transporter
SPD_RS08745	COG3201	nicotinamide mononucleotide transporter
SPD_RS08755	COG1174	glycine betaine transport
SPD_RS08780	COG1363	Peptidase, m42
SPD_RS08795	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPD_RS08800	COG4605	iron ion homeostasis
SPD_RS08805	COG4604	ABC transporter, ATP-binding protein
SPD_RS08810	COG4607	ABC-type enterochelin transport system periplasmic component
SPD_RS08820	COG1187	pseudouridine synthase activity
SPD_RS08840	COG0517	IMP dehydrogenase activity
SPD_RS08850	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SPD_RS08865	COG0366	Alpha amylase catalytic
SPD_RS08875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPD_RS08875	COG1263	PTS System
SPD_RS08880	COG2188	Transcriptional regulator
SPD_RS08890	COG4608	Belongs to the ABC transporter superfamily
SPD_RS08895	COG0444	Belongs to the ABC transporter superfamily
SPD_RS08900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPD_RS08905	COG0601	transmembrane transport
SPD_RS08910	COG4166	transmembrane transport
SPD_RS08925	COG0366	Alpha amylase catalytic
SPD_RS08930	COG0395	ABC-type sugar transport system, permease component
SPD_RS08935	COG1175	transmembrane transport
SPD_RS08940	COG1653	transport
SPD_RS08945	COG3345	alpha-galactosidase
SPD_RS08950	COG2207	Transcriptional regulator
SPD_RS08955	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPD_RS08955	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPD_RS09075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPD_RS09105	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SPD_RS09115	COG4221	oxidoreductase activity
SPD_RS09120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPD_RS09125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPD_RS09250	COG5263	repeat protein
SPD_RS09250	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPD_RS09270	COG1546	Belongs to the CinA family
SPD_RS09270	COG1058	Belongs to the CinA family
SPD_RS09275	COG1316	TRANSCRIPTIONal
SPD_RS09285	COG0802	atpase or kinase
SPD_RS09350	COG1136	(ABC) transporter
SPD_RS09375	COG1253	flavin adenine dinucleotide binding
SPD_RS09390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPD_RS09400	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPD_RS09405	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SPD_RS09410	COG0742	ribosomal rna small subunit methyltransferase
SPD_RS09415	COG2502	aspartate--ammonia ligase
SPD_RS09430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPD_RS09435	COG1254	Belongs to the acylphosphatase family
SPD_RS09440	COG0706	membrane insertase activity
SPD_RS09445	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPD_RS09455	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPD_RS09475	COG1564	THIamine pyrophosphokinase
SPD_RS09485	COG1162	GTPase activity
SPD_RS09490	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SPD_RS09515	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SPD_RS09520	COG0084	hydrolase, TatD family'
SPD_RS09540	COG0436	Aminotransferase
SPD_RS09550	COG0589	response to stress
SPD_RS09555	COG0561	phosphatase activity
SPD_RS09560	COG0252	asparaginase activity
SPD_RS09570	COG1609	Transcriptional regulator
SPD_RS09575	COG2197	response regulator
SPD_RS09580	COG4585	Histidine kinase
SPD_RS09585	COG0842	Transport permease protein
SPD_RS09590	COG1131	(ABC) transporter
SPD_RS09690	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPD_RS09695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPD_RS09700	COG0564	pseudouridine synthase activity
SPD_RS09710	COG0577	efflux transmembrane transporter activity
SPD_RS09720	COG0157	Belongs to the NadC ModD family
SPD_RS09735	COG1129	ABC transporter
SPD_RS09740	COG2188	Transcriptional regulator
SPD_RS09745	COG2723	6-phospho-beta-galactosidase activity
SPD_RS09750	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPD_RS09760	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPD_RS09765	COG1012	belongs to the aldehyde dehydrogenase family
SPD_RS09765	COG1454	alcohol dehydrogenase
SPD_RS09775	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPD_RS09785	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SPD_RS09805	COG3623	hexulose-6-phosphate isomerase
SPD_RS09815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPD_RS09825	COG3037	sugar-specific permease SgaT UlaA
SPD_RS09835	COG1847	R3H domain protein
SPD_RS09840	COG0706	membrane insertase activity
SPD_RS09850	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SPD_RS09885	COG4537	Required for transformation and DNA binding
SPD_RS09890	COG1459	type II secretion system
SPD_RS09895	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPD_RS09905	COG1063	alcohol dehydrogenase
SPD_RS09950	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SPD_RS09950	COG0131	Imidazoleglycerol-phosphate dehydratase
SPD_RS09955	COG0534	Mate efflux family protein
SPD_RS10055	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SPD_RS10070	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPD_RS10075	COG1132	(ABC) transporter
SPD_RS10085	COG1132	(ABC) transporter
SPD_RS10095	COG1438	arginine binding
SPD_RS10115	COG0745	RESPONSE REGULATOR receiver
SPD_RS10120	COG5002	protein histidine kinase activity
SPD_RS10125	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPD_RS10130	COG0573	inorganic phosphate transmembrane transporter activity
SPD_RS10140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPD_RS10145	COG0704	Plays a role in the regulation of phosphate uptake
SPD_RS10165	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPD_RS10175	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPD_RS10190	COG0697	spore germination
SPD_RS10195	COG4499	WXG100 protein secretion system (Wss), protein YukC
SPD_RS10195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPD_RS10205	COG2217	Heavy metal translocating P-type atpase
SPD_RS10215	COG2226	methyltransferase
SPD_RS10235	COG0058	SHG alpha-glucan phosphorylase activity
SPD_RS10240	COG1640	4-alpha-glucanotransferase
SPD_RS10245	COG2182	Extracellular solute-binding protein
SPD_RS10250	COG1175	transmembrane transport
SPD_RS10255	COG3833	ABC-type maltose transport systems, permease component
SPD_RS10265	COG5521	maltodextrose utilization protein MalA
SPD_RS10270	COG1609	Transcriptional regulator
SPD_RS10280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPD_RS10285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SPD_RS10315	COG1476	TRANSCRIPTIONal
SPD_RS10350	COG2151	metal-sulfur cluster biosynthetic enzyme
SPD_RS10360	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPD_RS10365	COG3959	Transketolase, thiamine diphosphate binding domain
SPD_RS10380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPD_RS10400	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPD_RS10430	COG0383	alpha-mannosidase activity
SPD_RS10440	COG3537	Alpha-1,2-mannosidase
SPD_RS10465	COG0549	Belongs to the carbamate kinase family
SPD_RS10470	COG1288	antiporter activity
SPD_RS10475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPD_RS10505	COG1454	alcohol dehydrogenase
SPD_RS10510	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
SPD_RS10525	COG3716	PTS system mannose fructose sorbose family IID component
SPD_RS10535	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPD_RS10555	COG1070	Carbohydrate kinase
SPD_RS10565	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPD_RS10565	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPD_RS10570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPD_RS10575	COG1121	(ABC) transporter
SPD_RS10580	COG1846	Transcriptional regulator
SPD_RS10585	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPD_RS10595	COG1696	Membrane protein involved in D-alanine export
SPD_RS10610	COG2211	Major facilitator Superfamily
SPD_RS10615	COG3344	reverse transcriptase
SPD_RS10640	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPD_RS10645	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SPD_RS10665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPD_RS10675	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPD_RS10680	COG5002	protein histidine kinase activity
SPD_RS10685	COG0745	RESPONSE REGULATOR receiver
SPD_RS10700	COG0542	response to heat
SPD_RS10705	COG4463	regulation of RNA biosynthetic process
SPD_RS10710	COG1116	anion transmembrane transporter activity
SPD_RS10715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SPD_RS10720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SPD_RS10740	COG0305	Participates in initiation and elongation during chromosome replication
SPD_RS10760	COG1040	competence protein
SPD_RS10765	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPD_RS10770	COG1739	Uncharacterized protein family UPF0029
SPD_RS10805	COG0052	Belongs to the universal ribosomal protein uS2 family
SPD_RS10810	COG3942	CHAP domain
SPD_RS10820	COG1792	Involved in formation and maintenance of cell shape
SPD_RS10825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPD_RS10830	COG1122	ATPase activity
SPD_RS10835	COG1122	ATPase activity
SPD_RS10840	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPD_RS10850	COG0612	Peptidase, M16
SPD_RS10855	COG0612	Peptidase, M16
SPD_RS10860	COG2501	S4 domain
SPD_RS10870	COG0517	IMP dehydrogenase activity
SPD_RS10870	COG0516	GMP reductase activity
SPD_RS10875	COG0180	Tryptophanyl-tRNA synthetase
SPD_RS10880	COG0488	(ABC) transporter
SPD_RS10900	COG1511	domain protein
SPD_RS10945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPD_RS10950	COG1475	DNA binding