locus-tag	class	description
SPG_RS00010	COG0592	DNA-directed DNA polymerase activity
SPG_RS00020	COG0012	GTP binding
SPG_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPG_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPG_RS00060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SPG_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPG_RS00135	COG0756	dUTP diphosphatase activity
SPG_RS00145	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SPG_RS00165	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPG_RS00185	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPG_RS00185	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPG_RS00195	COG2855	membrane
SPG_RS00200	COG0436	Aminotransferase
SPG_RS00215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPG_RS00240	COG2274	protein secretion by the type I secretion system
SPG_RS00245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPG_RS00255	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPG_RS00260	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SPG_RS00270	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPG_RS00285	COG0151	Belongs to the GarS family
SPG_RS00290	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPG_RS00305	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPG_RS00310	COG3064	Membrane
SPG_RS00310	COG3583	domain protein
SPG_RS00310	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPG_RS00325	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPG_RS00330	COG3715	PTS system
SPG_RS00335	COG3716	PTS system mannose fructose sorbose family IID component
SPG_RS00345	COG2222	sugar isomerase
SPG_RS00365	COG3583	domain protein
SPG_RS00370	COG2514	catechol 2,3-dioxygenase activity
SPG_RS00375	COG0110	maltose O-acetyltransferase activity
SPG_RS00390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPG_RS00395	COG0569	domain protein
SPG_RS00420	COG5002	protein histidine kinase activity
SPG_RS00440	COG4209	transmembrane transport
SPG_RS00445	COG0395	ABC-type sugar transport system, permease component
SPG_RS00450	COG1653	transport
SPG_RS00480	COG1695	Transcriptional regulator
SPG_RS00505	COG0546	phosphoglycolate phosphatase activity
SPG_RS00510	COG1760	l-serine dehydratase
SPG_RS00515	COG1760	l-serine dehydratase
SPG_RS00545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPG_RS00550	COG0137	argininosuccinate synthase activity
SPG_RS00640	COG0494	nUDIX hydrolase
SPG_RS00645	COG0445	tRNA wobble uridine modification
SPG_RS00675	COG1214	PFAM Peptidase M22, glycoprotease
SPG_RS00715	COG0438	transferase activity, transferring glycosyl groups
SPG_RS00755	COG1396	sequence-specific DNA binding
SPG_RS00790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPG_RS00795	COG1464	Belongs to the NlpA lipoprotein family
SPG_RS00800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPG_RS00805	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPG_RS00825	COG2972	Histidine kinase
SPG_RS00830	COG2207	Transcriptional regulator
SPG_RS00830	COG4753	response regulator
SPG_RS00840	COG1780	Probably involved in ribonucleotide reductase function
SPG_RS00870	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPG_RS00870	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPG_RS00890	COG0519	Catalyzes the synthesis of GMP from XMP
SPG_RS00915	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPG_RS00920	COG0006	proline dipeptidase activity
SPG_RS00925	COG1393	Belongs to the ArsC family
SPG_RS00950	COG0285	dihydrofolate synthase activity
SPG_RS00960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPG_RS00990	COG0602	queuosine metabolic process
SPG_RS01025	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPG_RS01050	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SPG_RS01090	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SPG_RS01105	COG0201	protein transport
SPG_RS01115	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SPG_RS01120	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SPG_RS01130	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SPG_RS01135	COG0202	RNA polymerase activity
SPG_RS01145	COG3830	Belongs to the UPF0237 family
SPG_RS01165	COG1178	ABC-type Fe3 transport system permease component
SPG_RS01170	COG3842	ATPase activity
SPG_RS01175	COG1840	ABC-type Fe3 transport system, periplasmic component
SPG_RS01190	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPG_RS01195	COG1349	DNA-binding transcription factor activity
SPG_RS01205	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPG_RS01210	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPG_RS01215	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPG_RS01220	COG1882	Formate acetyltransferase
SPG_RS01265	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPG_RS01270	COG4589	Belongs to the CDS family
SPG_RS01275	COG0750	zinc metalloprotease
SPG_RS01285	COG2723	6-phospho-beta-galactosidase activity
SPG_RS01290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPG_RS01300	COG1523	belongs to the glycosyl hydrolase 13 family
SPG_RS01320	COG2176	DNA-directed DNA polymerase activity
SPG_RS01340	COG2309	aminopeptidase activity
SPG_RS01345	COG2261	transglycosylase associated protein
SPG_RS01350	COG1187	pseudouridine synthase activity
SPG_RS01360	COG3579	cysteine-type endopeptidase activity
SPG_RS01365	COG3716	PTS system mannose fructose sorbose family IID component
SPG_RS01370	COG3715	PTS system
SPG_RS01380	COG1064	alcohol dehydrogenase
SPG_RS01390	COG2252	PERMEase
SPG_RS01400	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SPG_RS01405	COG0285	dihydrofolate synthase activity
SPG_RS01415	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SPG_RS01415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPG_RS01425	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPG_RS01450	COG0386	Belongs to the glutathione peroxidase family
SPG_RS01455	COG5492	domain, Protein
SPG_RS01480	COG1028	Short-chain dehydrogenase reductase Sdr
SPG_RS01490	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SPG_RS01495	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPG_RS01500	COG3715	PTS system
SPG_RS01505	COG3716	PTS system mannose fructose sorbose family IID component
SPG_RS01520	COG1609	Transcriptional regulator
SPG_RS01550	COG4839	cell division protein FtsL
SPG_RS01555	COG0768	penicillin binding
SPG_RS01580	COG0366	Alpha amylase catalytic
SPG_RS01585	COG4166	transmembrane transport
SPG_RS01625	COG3475	LICD family
SPG_RS01645	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SPG_RS01650	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SPG_RS01660	COG1088	dTDP-glucose 4,6-dehydratase activity
SPG_RS01665	COG1091	dTDP-4-dehydrorhamnose reductase activity
SPG_RS01685	COG4166	transmembrane transport
SPG_RS01690	COG0366	Alpha amylase catalytic
SPG_RS01695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPG_RS01720	COG0116	Belongs to the methyltransferase superfamily
SPG_RS01730	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SPG_RS01735	COG0745	RESPONSE REGULATOR receiver
SPG_RS01770	COG1304	FMN binding
SPG_RS01780	COG4585	Histidine kinase
SPG_RS01785	COG2197	response regulator
SPG_RS01820	COG2801	Transposase and inactivated derivatives
SPG_RS01835	COG2213	PTS system mannitol-specific
SPG_RS01840	COG3711	transcriptional antiterminator
SPG_RS01845	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPG_RS01870	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPG_RS01875	COG0681	Belongs to the peptidase S26 family
SPG_RS01900	COG1115	amino acid carrier protein
SPG_RS01925	COG0527	aspartate kinase activity
SPG_RS01930	COG1024	Enoyl-CoA hydratase
SPG_RS01935	COG1846	Transcriptional regulator
SPG_RS01945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPG_RS01955	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPG_RS01960	COG1028	Short-chain dehydrogenase reductase Sdr
SPG_RS01965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPG_RS01980	COG0439	Biotin carboxylase
SPG_RS01985	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPG_RS02045	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SPG_RS02055	COG1461	Dihydroxyacetone kinase
SPG_RS02065	COG0028	Belongs to the TPP enzyme family
SPG_RS02070	COG0440	acetolactate synthase activity
SPG_RS02090	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SPG_RS02105	COG0765	amino acid transport
SPG_RS02135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPG_RS02140	COG1882	Formate acetyltransferase
SPG_RS02170	COG1940	carbohydrate kinase activity
SPG_RS02175	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPG_RS02190	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPG_RS02195	COG2723	6-phospho-beta-galactosidase activity
SPG_RS02200	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPG_RS02200	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPG_RS02205	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPG_RS02210	COG0569	domain protein
SPG_RS02230	COG1122	ATPase activity
SPG_RS02245	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPG_RS02250	COG0671	phosphoesterase, PA-phosphatase related
SPG_RS02260	COG1247	-acetyltransferase
SPG_RS02275	COG0504	CTP synthase activity
SPG_RS02280	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPG_RS02310	COG0789	Transcriptional regulator
SPG_RS02315	COG0174	glutamine synthetase
SPG_RS02325	COG0732	type I restriction modification DNA specificity domain
SPG_RS02335	COG0732	type I restriction modification DNA specificity domain
SPG_RS02380	COG0484	heat shock protein binding
SPG_RS02390	COG0537	adenosine 5'-monophosphoramidase activity
SPG_RS02395	COG1131	(ABC) transporter
SPG_RS02420	COG3290	protein histidine kinase activity
SPG_RS02430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPG_RS02435	COG2274	protein secretion by the type I secretion system
SPG_RS02505	COG1266	CAAX protease self-immunity
SPG_RS02525	COG0195	Participates in both transcription termination and antitermination
SPG_RS02530	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPG_RS02600	COG0519	Catalyzes the synthesis of GMP from XMP
SPG_RS02610	COG0525	valine-tRNA ligase activity
SPG_RS02630	COG2801	Transposase and inactivated derivatives
SPG_RS02645	COG3711	transcriptional antiterminator
SPG_RS02650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPG_RS02650	COG1263	PTS System
SPG_RS02650	COG2190	(PTS) system
SPG_RS02665	COG0456	acetyltransferase
SPG_RS02670	COG0072	phenylalanine-tRNA ligase activity
SPG_RS02670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPG_RS02690	COG3620	sequence-specific DNA binding
SPG_RS02710	COG1045	serine acetyltransferase
SPG_RS02720	COG0215	cysteine-tRNA ligase activity
SPG_RS02725	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPG_RS02745	COG0577	efflux transmembrane transporter activity
SPG_RS02750	COG1136	(ABC) transporter
SPG_RS02755	COG0577	efflux transmembrane transporter activity
SPG_RS02760	COG0745	RESPONSE REGULATOR receiver
SPG_RS02765	COG5002	protein histidine kinase activity
SPG_RS02770	COG0191	fructose-bisphosphate aldolase activity
SPG_RS02775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SPG_RS02785	COG0765	amino acid transport
SPG_RS02790	COG0765	amino acid transport
SPG_RS02795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPG_RS02805	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPG_RS02805	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPG_RS02845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPG_RS02860	COG1573	uracil-dna glycosylase
SPG_RS02870	COG1114	Component of the transport system for branched-chain amino acids
SPG_RS02875	COG1363	Peptidase, m42
SPG_RS02930	COG4555	ABC transporter
SPG_RS02960	COG1404	Belongs to the peptidase S8 family
SPG_RS02975	COG3775	system Galactitol-specific IIC component
SPG_RS02985	COG3250	beta-galactosidase activity
SPG_RS03010	COG1242	4 iron, 4 sulfur cluster binding
SPG_RS03015	COG1242	4 iron, 4 sulfur cluster binding
SPG_RS03020	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPG_RS03040	COG0785	Cytochrome C biogenesis protein
SPG_RS03045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPG_RS03050	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPG_RS03050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPG_RS03055	COG2207	Transcriptional regulator
SPG_RS03055	COG4753	response regulator
SPG_RS03060	COG2972	Histidine kinase
SPG_RS03070	COG3064	Membrane
SPG_RS03075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPG_RS03090	COG1940	carbohydrate kinase activity
SPG_RS03110	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPG_RS03115	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPG_RS03125	COG0300	oxidoreductase activity
SPG_RS03140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPG_RS03150	COG1187	pseudouridine synthase activity
SPG_RS03175	COG1136	(ABC) transporter
SPG_RS03190	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SPG_RS03225	COG1131	(ABC) transporter
SPG_RS03230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPG_RS03240	COG1126	abc transporter atp-binding protein
SPG_RS03245	COG1126	abc transporter atp-binding protein
SPG_RS03260	COG1304	FMN binding
SPG_RS03270	COG1304	FMN binding
SPG_RS03290	COG0352	thiamine-phosphate diphosphorylase activity
SPG_RS03300	COG1122	ATPase activity
SPG_RS03310	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SPG_RS03325	COG0352	thiamine-phosphate diphosphorylase activity
SPG_RS03345	COG2217	Heavy metal translocating P-type atpase
SPG_RS03350	COG0028	Belongs to the TPP enzyme family
SPG_RS03365	COG3335	DDE superfamily endonuclease
SPG_RS03375	COG2723	6-phospho-beta-galactosidase activity
SPG_RS03380	COG1482	cell wall glycoprotein biosynthetic process
SPG_RS03385	COG0733	neurotransmitter:sodium symporter activity
SPG_RS03390	COG0789	Transcriptional regulator
SPG_RS03400	COG2081	HI0933 family
SPG_RS03405	COG1307	EDD domain protein, DegV family
SPG_RS03415	COG2131	deaminase
SPG_RS03420	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SPG_RS03460	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPG_RS03460	COG0617	tRNA 3'-terminal CCA addition
SPG_RS03460	COG0517	IMP dehydrogenase activity
SPG_RS03465	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SPG_RS03470	COG2884	Cell division ATP-binding protein ftsE
SPG_RS03475	COG2177	Part of the ABC transporter FtsEX involved in
SPG_RS03490	COG0513	Belongs to the DEAD box helicase family
SPG_RS03500	COG0167	dihydroorotate dehydrogenase activity
SPG_RS03510	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SPG_RS03515	COG4470	Protein conserved in bacteria
SPG_RS03530	COG0488	(ABC) transporter
SPG_RS03555	COG1837	Belongs to the UPF0109 family
SPG_RS03575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPG_RS03575	COG1328	CTP reductase activity
SPG_RS03585	COG4443	Transcriptional Coactivator p15 (PC4)
SPG_RS03595	COG1268	BioY protein
SPG_RS03600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPG_RS03605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPG_RS03610	COG1136	(ABC) transporter
SPG_RS03615	COG0577	efflux transmembrane transporter activity
SPG_RS03620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPG_RS03620	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPG_RS03640	COG4989	oxidoreductase activity
SPG_RS03650	COG1028	Short-chain dehydrogenase reductase Sdr
SPG_RS03675	COG0745	RESPONSE REGULATOR receiver
SPG_RS03680	COG5002	protein histidine kinase activity
SPG_RS03700	COG0772	Belongs to the SEDS family
SPG_RS03705	COG0693	protein deglycase activity
SPG_RS03715	COG0187	DNA topoisomerase II activity
SPG_RS03735	COG0494	nUDIX hydrolase
SPG_RS03755	COG0542	response to heat
SPG_RS03760	COG4703	Protein of unknown function (DUF1797)
SPG_RS03765	COG0765	amino acid transport
SPG_RS03770	COG1126	abc transporter atp-binding protein
SPG_RS03775	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPG_RS03780	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SPG_RS03800	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SPG_RS03845	COG2813	Specifically methylates the guanine in position
SPG_RS03850	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SPG_RS03860	COG0295	cytidine deaminase activity
SPG_RS03865	COG1744	ABC transporter substrate-binding protein PnrA-like
SPG_RS03870	COG3845	ABC transporter
SPG_RS03875	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPG_RS03880	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPG_RS03905	COG0187	DNA topoisomerase II activity
SPG_RS03915	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPG_RS03920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPG_RS03925	COG4166	transmembrane transport
SPG_RS03960	COG0539	negative regulation of cytoplasmic translation
SPG_RS03980	COG1956	GAF domain-containing protein
SPG_RS03985	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPG_RS04000	COG0719	Fe-S assembly protein
SPG_RS04005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPG_RS04015	COG0719	Fe-S assembly protein
SPG_RS04025	COG1686	Belongs to the peptidase S11 family
SPG_RS04030	COG0628	permease
SPG_RS04040	COG1349	DNA-binding transcription factor activity
SPG_RS04045	COG1105	Belongs to the carbohydrate kinase PfkB family
SPG_RS04050	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPG_RS04050	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPG_RS04050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPG_RS04055	COG0697	spore germination
SPG_RS04055	COG1674	ftsk spoiiie
SPG_RS04065	COG1104	cysteine desulfurase activity
SPG_RS04095	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SPG_RS04125	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
SPG_RS04135	COG1438	arginine binding
SPG_RS04160	COG0582	viral genome integration into host DNA
SPG_RS04195	COG3689	TIGRFAM TIGR03943 family protein
SPG_RS04200	COG0701	Predicted permease
SPG_RS04210	COG2183	response to ionizing radiation
SPG_RS04230	COG1136	(ABC) transporter
SPG_RS04235	COG0577	efflux transmembrane transporter activity
SPG_RS04250	COG1982	Orn Lys Arg decarboxylase major
SPG_RS04260	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SPG_RS04280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPG_RS04285	COG0561	phosphatase activity
SPG_RS04305	COG0583	DNA-binding transcription factor activity
SPG_RS04310	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPG_RS04315	COG0564	pseudouridine synthase activity
SPG_RS04320	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPG_RS04335	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPG_RS04345	COG0470	DNA polymerase III
SPG_RS04395	COG0528	UMP kinase activity
SPG_RS04405	COG2996	Protein conserved in bacteria
SPG_RS04415	COG1702	phosphate starvation-inducible protein PhoH
SPG_RS04420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPG_RS04425	COG1555	photosystem II stabilization
SPG_RS04425	COG1596	polysaccharide export
SPG_RS04430	COG2333	competence protein COMEC
SPG_RS04430	COG0658	competence protein
SPG_RS04440	COG1131	(ABC) transporter
SPG_RS04470	COG0543	2 iron, 2 sulfur cluster binding
SPG_RS04475	COG0167	dihydroorotate dehydrogenase activity
SPG_RS04480	COG4193	domain, Protein
SPG_RS04480	COG5263	repeat protein
SPG_RS04485	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPG_RS04495	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPG_RS04505	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPG_RS04510	COG0237	dephospho-CoA kinase activity
SPG_RS04515	COG2814	Major facilitator Superfamily
SPG_RS04530	COG0557	exoribonuclease II activity
SPG_RS04540	COG0500	methyltransferase
SPG_RS04540	COG3615	Tellurite resistance protein tehB
SPG_RS04555	COG4122	O-methyltransferase activity
SPG_RS04580	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SPG_RS04600	COG0494	nUDIX hydrolase
SPG_RS04610	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPG_RS04620	COG2176	DNA-directed DNA polymerase activity
SPG_RS04625	COG0584	glycerophosphoryl diester phosphodiesterase
SPG_RS04650	COG0785	Cytochrome C biogenesis protein
SPG_RS04655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPG_RS04660	COG0531	amino acid
SPG_RS04665	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPG_RS04665	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPG_RS04705	COG1970	mechanosensitive ion channel activity
SPG_RS04715	COG4708	membrane
SPG_RS04725	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPG_RS04735	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SPG_RS04740	COG1942	4-Oxalocrotonate Tautomerase
SPG_RS04745	COG1435	thymidine kinase activity
SPG_RS04755	COG2890	protein-(glutamine-N5) methyltransferase activity
SPG_RS04780	COG0741	lytic transglycosylase activity
SPG_RS04790	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPG_RS04815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPG_RS04820	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPG_RS04895	COG1597	lipid kinase activity
SPG_RS04900	COG0366	Alpha amylase catalytic
SPG_RS04945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPG_RS04965	COG1396	sequence-specific DNA binding
SPG_RS04975	COG0772	Belongs to the SEDS family
SPG_RS04980	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SPG_RS04995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPG_RS05000	COG0358	DNA primase activity
SPG_RS05005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPG_RS05010	COG2151	metal-sulfur cluster biosynthetic enzyme
SPG_RS05015	COG0438	transferase activity, transferring glycosyl groups
SPG_RS05020	COG0438	transferase activity, transferring glycosyl groups
SPG_RS05045	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPG_RS05055	COG4109	DRTGG domain
SPG_RS05060	COG0024	Methionine aminopeptidase
SPG_RS05075	COG0210	DNA helicase
SPG_RS05085	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPG_RS05105	COG1104	cysteine desulfurase activity
SPG_RS05110	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPG_RS05120	COG2357	RelA SpoT domain protein
SPG_RS05130	COG0564	pseudouridine synthase activity
SPG_RS05135	COG0280	phosphate acetyltransferase
SPG_RS05175	COG0196	riboflavin kinase activity
SPG_RS05180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPG_RS05185	COG1307	EDD domain protein, DegV family
SPG_RS05195	COG0488	(ABC) transporter
SPG_RS05225	COG1012	belongs to the aldehyde dehydrogenase family
SPG_RS05230	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SPG_RS05240	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SPG_RS05250	COG0560	Phosphoserine phosphatase
SPG_RS05255	COG0560	Phosphoserine phosphatase
SPG_RS05315	COG3064	Membrane
SPG_RS05325	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPG_RS05345	COG0095	Lipoate-protein ligase
SPG_RS05350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPG_RS05355	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPG_RS05360	COG0022	dehydrogenase e1 component
SPG_RS05365	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPG_RS05370	COG0534	Mate efflux family protein
SPG_RS05380	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPG_RS05385	COG1051	belongs to the nudix hydrolase family
SPG_RS05400	COG1011	Hydrolase
SPG_RS05420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPG_RS05425	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPG_RS05430	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPG_RS05435	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPG_RS05445	COG2723	6-phospho-beta-galactosidase activity
SPG_RS05460	COG3711	transcriptional antiterminator
SPG_RS05465	COG3684	Belongs to the aldolase LacD family
SPG_RS05520	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SPG_RS05525	COG0497	DNA recombination
SPG_RS05530	COG1438	arginine binding
SPG_RS05535	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPG_RS05570	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SPG_RS05595	COG3764	Sortase (surface protein transpeptidase)
SPG_RS05600	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPG_RS05610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SPG_RS05625	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPG_RS05630	COG5002	protein histidine kinase activity
SPG_RS05635	COG0745	RESPONSE REGULATOR receiver
SPG_RS05640	COG1194	a g-specific adenine glycosylase
SPG_RS05655	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPG_RS05660	COG4684	Psort location CytoplasmicMembrane, score
SPG_RS05670	COG1827	regulation of RNA biosynthetic process
SPG_RS05700	COG0765	amino acid transport
SPG_RS05705	COG1126	abc transporter atp-binding protein
SPG_RS05710	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPG_RS05715	COG0552	protein localization to endoplasmic reticulum
SPG_RS05720	COG0561	phosphatase activity
SPG_RS05725	COG0561	phosphatase activity
SPG_RS05730	COG1196	nuclear chromosome segregation
SPG_RS05770	COG0066	3-isopropylmalate dehydratase activity
SPG_RS05780	COG0473	3-isopropylmalate dehydrogenase activity
SPG_RS05785	COG0473	3-isopropylmalate dehydrogenase activity
SPG_RS05805	COG2832	Protein of unknown function (DUF454)
SPG_RS05810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPG_RS05820	COG0758	DNA mediated transformation
SPG_RS05825	COG4750	Nucleotidyl transferase
SPG_RS05840	COG1063	alcohol dehydrogenase
SPG_RS05855	COG3475	LICD family
SPG_RS05860	COG3475	LICD family
SPG_RS05870	COG0505	Belongs to the CarA family
SPG_RS05885	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPG_RS05900	COG0488	(ABC) transporter
SPG_RS05910	COG1704	LemA family
SPG_RS05925	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPG_RS05940	COG1078	dGTPase activity
SPG_RS05960	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPG_RS05965	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPG_RS05970	COG1605	Chorismate mutase
SPG_RS05970	COG0077	Prephenate dehydratase
SPG_RS05975	COG0716	FMN binding
SPG_RS05980	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPG_RS06000	COG3335	DDE superfamily endonuclease
SPG_RS06010	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPG_RS06095	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPG_RS06100	COG1269	ATP hydrolysis coupled proton transport
SPG_RS06115	COG0673	inositol 2-dehydrogenase activity
SPG_RS06120	COG4409	exo-alpha-(2->6)-sialidase activity
SPG_RS06130	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPG_RS06135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPG_RS06140	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SPG_RS06145	COG1737	Transcriptional regulator
SPG_RS06180	COG0791	NLP P60 protein
SPG_RS06180	COG0741	lytic transglycosylase activity
SPG_RS06225	COG2946	Replication initiation factor
SPG_RS06230	COG1674	ftsk spoiiie
SPG_RS06340	COG1396	sequence-specific DNA binding
SPG_RS06415	COG1136	(ABC) transporter
SPG_RS06455	COG0270	DNA (cytosine-5-)-methyltransferase activity
SPG_RS06475	COG0402	S-adenosylhomocysteine deaminase activity
SPG_RS06485	COG1132	(ABC) transporter
SPG_RS06490	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPG_RS06490	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPG_RS06525	COG1215	transferase activity, transferring glycosyl groups
SPG_RS06535	COG3475	LICD family
SPG_RS06545	COG0077	Prephenate dehydratase
SPG_RS06550	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SPG_RS06565	COG0287	Prephenate dehydrogenase
SPG_RS06590	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPG_RS06600	COG1131	(ABC) transporter
SPG_RS06640	COG3842	ATPase activity
SPG_RS06655	COG3527	Alpha-acetolactate decarboxylase
SPG_RS06665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPG_RS06670	COG0704	Plays a role in the regulation of phosphate uptake
SPG_RS06675	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPG_RS06680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPG_RS06685	COG0581	inorganic phosphate transmembrane transporter activity
SPG_RS06690	COG0573	inorganic phosphate transmembrane transporter activity
SPG_RS06695	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPG_RS06700	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPG_RS06700	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPG_RS06705	COG0483	inositol monophosphate 1-phosphatase activity
SPG_RS06715	COG1393	Belongs to the ArsC family
SPG_RS06725	COG0647	UMP catabolic process
SPG_RS06735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPG_RS06785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPG_RS06795	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPG_RS06820	COG0826	peptidase U32
SPG_RS06830	COG0826	peptidase U32
SPG_RS06855	COG2188	Transcriptional regulator
SPG_RS06860	COG0697	spore germination
SPG_RS06865	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPG_RS06880	COG0561	phosphatase activity
SPG_RS06910	COG0492	ferredoxin-NADP+ reductase activity
SPG_RS06920	COG1126	abc transporter atp-binding protein
SPG_RS06930	COG1393	Belongs to the ArsC family
SPG_RS06950	COG1272	protein, Hemolysin III
SPG_RS06980	COG3976	FMN-binding domain protein
SPG_RS06980	COG1053	succinate dehydrogenase
SPG_RS06980	COG0431	NADPH-dependent FMN reductase
SPG_RS07005	COG0656	L-ascorbic acid biosynthetic process
SPG_RS07015	COG0726	polysaccharide deacetylase
SPG_RS07040	COG3335	DDE superfamily endonuclease
SPG_RS07055	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPG_RS07090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPG_RS07100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPG_RS07105	COG1126	abc transporter atp-binding protein
SPG_RS07120	COG0628	permease
SPG_RS07125	COG2706	6-phosphogluconolactonase activity
SPG_RS07185	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPG_RS07210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPG_RS07215	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SPG_RS07220	COG0626	cystathionine gamma-synthase activity
SPG_RS07225	COG1132	(ABC) transporter
SPG_RS07240	COG4166	transmembrane transport
SPG_RS07245	COG2244	polysaccharide biosynthetic process
SPG_RS07250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPG_RS07275	COG2827	Endonuclease containing a URI domain
SPG_RS07280	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPG_RS07285	COG1098	S1 RNA binding domain
SPG_RS07295	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPG_RS07300	COG0629	single-stranded DNA binding
SPG_RS07310	COG0017	Asparaginyl-tRNA synthetase
SPG_RS07320	COG0436	Aminotransferase
SPG_RS07355	COG0242	peptide deformylase activity
SPG_RS07360	COG0625	glutathione transferase activity
SPG_RS07370	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPG_RS07375	COG0488	(ABC) transporter
SPG_RS07390	COG1307	EDD domain protein, DegV family
SPG_RS07410	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPG_RS07425	COG1481	regulation of sporulation
SPG_RS07430	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SPG_RS07440	COG0251	oxidation-reduction process
SPG_RS07460	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPG_RS07470	COG4193	domain, Protein
SPG_RS07470	COG5263	repeat protein
SPG_RS07480	COG3935	DnaD domain protein
SPG_RS07495	COG2226	methyltransferase
SPG_RS07505	COG3842	ATPase activity
SPG_RS07515	COG1335	isochorismatase
SPG_RS07525	COG0513	Belongs to the DEAD box helicase family
SPG_RS07530	COG2223	nitrite transmembrane transporter activity
SPG_RS07535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPG_RS07540	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPG_RS07545	COG3442	glutamine amidotransferase
SPG_RS07550	COG0006	proline dipeptidase activity
SPG_RS07555	COG2801	Transposase and inactivated derivatives
SPG_RS07570	COG4720	Psort location CytoplasmicMembrane, score
SPG_RS07575	COG0351	phosphomethylpyrimidine kinase
SPG_RS07600	COG2824	Alkylphosphonate utilization operon protein PhnA
SPG_RS07620	COG0463	Glycosyl transferase, family 2
SPG_RS07625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPG_RS07635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPG_RS07640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SPG_RS07645	COG2384	SAM-dependent methyltransferase
SPG_RS07650	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SPG_RS07655	COG0204	Acyl-transferase
SPG_RS07670	COG2910	NAD(P)H-binding
SPG_RS07690	COG5002	protein histidine kinase activity
SPG_RS07695	COG0745	RESPONSE REGULATOR receiver
SPG_RS07710	COG1959	2 iron, 2 sulfur cluster binding
SPG_RS07760	COG3590	peptidase
SPG_RS07775	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPG_RS07780	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SPG_RS07790	COG0577	efflux transmembrane transporter activity
SPG_RS07790	COG1136	(ABC) transporter
SPG_RS07835	COG3599	regulation of cell shape
SPG_RS07855	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPG_RS07875	COG1051	belongs to the nudix hydrolase family
SPG_RS07880	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPG_RS07895	COG0768	penicillin binding
SPG_RS07910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPG_RS07925	COG2731	YhcH YjgK YiaL family protein
SPG_RS07930	COG0395	ABC-type sugar transport system, permease component
SPG_RS07935	COG1175	transmembrane transport
SPG_RS07945	COG2190	(PTS) system
SPG_RS07945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPG_RS07945	COG1263	PTS System
SPG_RS07955	COG0673	inositol 2-dehydrogenase activity
SPG_RS07960	COG4409	exo-alpha-(2->6)-sialidase activity
SPG_RS07970	COG1175	transmembrane transport
SPG_RS07975	COG1653	transport
SPG_RS07995	COG3458	cephalosporin-C deacetylase activity
SPG_RS08000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPG_RS08015	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPG_RS08020	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPG_RS08035	COG1131	(ABC) transporter
SPG_RS08065	COG0778	Nitroreductase
SPG_RS08070	COG1484	DNA-dependent DNA replication
SPG_RS08085	COG1725	Transcriptional regulator
SPG_RS08090	COG1131	(ABC) transporter
SPG_RS08100	COG1668	transmembrane transport
SPG_RS08105	COG4152	abc transporter atp-binding protein
SPG_RS08125	COG1940	carbohydrate kinase activity
SPG_RS08130	COG1263	PTS System
SPG_RS08130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPG_RS08130	COG2190	(PTS) system
SPG_RS08140	COG1621	beta-fructofuranosidase activity
SPG_RS08145	COG1609	Transcriptional regulator
SPG_RS08155	COG3425	synthase
SPG_RS08185	COG0631	protein serine/threonine phosphatase activity
SPG_RS08190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPG_RS08190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPG_RS08200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPG_RS08210	COG0194	GDP metabolic process
SPG_RS08230	COG2226	methyltransferase
SPG_RS08235	COG0799	negative regulation of ribosome biogenesis
SPG_RS08245	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPG_RS08250	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SPG_RS08255	COG1534	Rna-binding protein
SPG_RS08260	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPG_RS08275	COG0668	transmembrane transport
SPG_RS08300	COG3118	belongs to the thioredoxin family
SPG_RS08305	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SPG_RS08315	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPG_RS08330	COG1164	Oligoendopeptidase f
SPG_RS08335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPG_RS08345	COG1051	belongs to the nudix hydrolase family
SPG_RS08380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPG_RS08390	COG1621	beta-fructofuranosidase activity
SPG_RS08395	COG0395	ABC-type sugar transport system, permease component
SPG_RS08400	COG1175	transmembrane transport
SPG_RS08410	COG1609	Transcriptional regulator
SPG_RS08415	COG3711	transcriptional antiterminator
SPG_RS08440	COG3237	CsbD-like
SPG_RS08455	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPG_RS08465	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPG_RS08470	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPG_RS08480	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPG_RS08485	COG1846	Transcriptional regulator
SPG_RS08485	COG1940	carbohydrate kinase activity
SPG_RS08535	COG0512	Glutamine amidotransferase of anthranilate synthase
SPG_RS08540	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPG_RS08565	COG1285	pathogenesis
SPG_RS08570	COG1178	ABC-type Fe3 transport system permease component
SPG_RS08595	COG5434	Belongs to the glycosyl hydrolase 28 family
SPG_RS08610	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SPG_RS08615	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPG_RS08620	COG1132	(ABC) transporter
SPG_RS08625	COG1132	(ABC) transporter
SPG_RS08650	COG0708	Exodeoxyribonuclease III
SPG_RS08670	COG2233	PERMEase
SPG_RS08700	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPG_RS08705	COG1609	Transcriptional regulator
SPG_RS08715	COG0789	Transcriptional regulator
SPG_RS08720	COG1230	cation diffusion facilitator family transporter
SPG_RS08730	COG3201	nicotinamide mononucleotide transporter
SPG_RS08735	COG1174	glycine betaine transport
SPG_RS08760	COG1363	Peptidase, m42
SPG_RS08775	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPG_RS08780	COG4605	iron ion homeostasis
SPG_RS08785	COG4604	ABC transporter, ATP-binding protein
SPG_RS08790	COG4607	ABC-type enterochelin transport system periplasmic component
SPG_RS08800	COG1187	pseudouridine synthase activity
SPG_RS08820	COG0517	IMP dehydrogenase activity
SPG_RS08830	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SPG_RS08845	COG0366	Alpha amylase catalytic
SPG_RS08850	COG1263	PTS System
SPG_RS08850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPG_RS08855	COG2188	Transcriptional regulator
SPG_RS08875	COG4608	Belongs to the ABC transporter superfamily
SPG_RS08880	COG0444	Belongs to the ABC transporter superfamily
SPG_RS08885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPG_RS08890	COG0601	transmembrane transport
SPG_RS08895	COG4166	transmembrane transport
SPG_RS08910	COG0366	Alpha amylase catalytic
SPG_RS08920	COG0395	ABC-type sugar transport system, permease component
SPG_RS08925	COG1175	transmembrane transport
SPG_RS08930	COG1653	transport
SPG_RS08935	COG3345	alpha-galactosidase
SPG_RS08940	COG2207	Transcriptional regulator
SPG_RS08945	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPG_RS08945	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPG_RS09060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPG_RS09110	COG4221	oxidoreductase activity
SPG_RS09115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPG_RS09120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPG_RS09155	COG1132	(ABC) transporter
SPG_RS09245	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPG_RS09245	COG5263	repeat protein
SPG_RS09265	COG1316	TRANSCRIPTIONal
SPG_RS09275	COG0802	atpase or kinase
SPG_RS09300	COG0577	efflux transmembrane transporter activity
SPG_RS09300	COG1136	(ABC) transporter
SPG_RS09330	COG1253	flavin adenine dinucleotide binding
SPG_RS09345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPG_RS09355	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPG_RS09365	COG0742	ribosomal rna small subunit methyltransferase
SPG_RS09385	COG1254	Belongs to the acylphosphatase family
SPG_RS09395	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPG_RS09405	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPG_RS09420	COG1564	THIamine pyrophosphokinase
SPG_RS09430	COG1162	GTPase activity
SPG_RS09445	COG1136	(ABC) transporter
SPG_RS09445	COG0577	efflux transmembrane transporter activity
SPG_RS09465	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SPG_RS09470	COG0084	hydrolase, TatD family'
SPG_RS09485	COG0436	Aminotransferase
SPG_RS09495	COG0589	response to stress
SPG_RS09500	COG0561	phosphatase activity
SPG_RS09505	COG0252	asparaginase activity
SPG_RS09510	COG1609	Transcriptional regulator
SPG_RS09515	COG2197	response regulator
SPG_RS09520	COG4585	Histidine kinase
SPG_RS09525	COG0842	Transport permease protein
SPG_RS09530	COG1131	(ABC) transporter
SPG_RS09630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPG_RS09635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPG_RS09650	COG0577	efflux transmembrane transporter activity
SPG_RS09665	COG0157	Belongs to the NadC ModD family
SPG_RS09675	COG4133	protoheme IX ABC transporter activity
SPG_RS09680	COG2188	Transcriptional regulator
SPG_RS09685	COG2723	6-phospho-beta-galactosidase activity
SPG_RS09690	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPG_RS09700	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPG_RS09705	COG1012	belongs to the aldehyde dehydrogenase family
SPG_RS09705	COG1454	alcohol dehydrogenase
SPG_RS09715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPG_RS09725	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SPG_RS09745	COG3623	hexulose-6-phosphate isomerase
SPG_RS09755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPG_RS09765	COG3037	sugar-specific permease SgaT UlaA
SPG_RS09775	COG1847	R3H domain protein
SPG_RS09780	COG0706	membrane insertase activity
SPG_RS09830	COG4537	Required for transformation and DNA binding
SPG_RS09835	COG1459	type II secretion system
SPG_RS09840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPG_RS09850	COG1063	alcohol dehydrogenase
SPG_RS09875	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SPG_RS09880	COG3759	membrane
SPG_RS09895	COG0131	Imidazoleglycerol-phosphate dehydratase
SPG_RS09895	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SPG_RS09900	COG0534	Mate efflux family protein
SPG_RS09935	COG0582	viral genome integration into host DNA
SPG_RS09950	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SPG_RS10055	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPG_RS10060	COG1132	(ABC) transporter
SPG_RS10070	COG1132	(ABC) transporter
SPG_RS10080	COG1438	arginine binding
SPG_RS10100	COG0745	RESPONSE REGULATOR receiver
SPG_RS10105	COG5002	protein histidine kinase activity
SPG_RS10110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPG_RS10115	COG0573	inorganic phosphate transmembrane transporter activity
SPG_RS10125	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPG_RS10130	COG0704	Plays a role in the regulation of phosphate uptake
SPG_RS10150	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPG_RS10160	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPG_RS10175	COG0697	spore germination
SPG_RS10180	COG4499	WXG100 protein secretion system (Wss), protein YukC
SPG_RS10180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPG_RS10190	COG2217	Heavy metal translocating P-type atpase
SPG_RS10200	COG2226	methyltransferase
SPG_RS10220	COG0058	SHG alpha-glucan phosphorylase activity
SPG_RS10225	COG1640	4-alpha-glucanotransferase
SPG_RS10230	COG2182	Extracellular solute-binding protein
SPG_RS10235	COG1175	transmembrane transport
SPG_RS10240	COG3833	ABC-type maltose transport systems, permease component
SPG_RS10245	COG5521	maltodextrose utilization protein MalA
SPG_RS10250	COG1609	Transcriptional regulator
SPG_RS10260	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPG_RS10295	COG1476	TRANSCRIPTIONal
SPG_RS10325	COG2151	metal-sulfur cluster biosynthetic enzyme
SPG_RS10340	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPG_RS10345	COG3959	Transketolase, thiamine diphosphate binding domain
SPG_RS10380	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPG_RS10425	COG0383	alpha-mannosidase activity
SPG_RS10435	COG3537	Alpha-1,2-mannosidase
SPG_RS10455	COG0549	Belongs to the carbamate kinase family
SPG_RS10460	COG1288	antiporter activity
SPG_RS10465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPG_RS10475	COG3583	domain protein
SPG_RS10475	COG3064	Membrane
SPG_RS10475	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPG_RS10485	COG1454	alcohol dehydrogenase
SPG_RS10495	COG0235	Class ii aldolase
SPG_RS10525	COG1175	transmembrane transport
SPG_RS10530	COG1653	transport
SPG_RS10535	COG1070	Carbohydrate kinase
SPG_RS10545	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPG_RS10545	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPG_RS10550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPG_RS10555	COG1121	(ABC) transporter
SPG_RS10560	COG1846	Transcriptional regulator
SPG_RS10565	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPG_RS10575	COG1696	Membrane protein involved in D-alanine export
SPG_RS10590	COG2211	Major facilitator Superfamily
SPG_RS10595	COG3344	reverse transcriptase
SPG_RS10610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPG_RS10615	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SPG_RS10635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPG_RS10645	COG2801	Transposase and inactivated derivatives
SPG_RS10665	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPG_RS10670	COG5002	protein histidine kinase activity
SPG_RS10675	COG0745	RESPONSE REGULATOR receiver
SPG_RS10685	COG0542	response to heat
SPG_RS10690	COG4463	regulation of RNA biosynthetic process
SPG_RS10695	COG1116	anion transmembrane transporter activity
SPG_RS10700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SPG_RS10705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SPG_RS10725	COG0305	Participates in initiation and elongation during chromosome replication
SPG_RS10745	COG1040	competence protein
SPG_RS10750	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPG_RS10755	COG1739	Uncharacterized protein family UPF0029
SPG_RS10770	COG3335	DDE superfamily endonuclease
SPG_RS10790	COG3942	CHAP domain
SPG_RS10800	COG1792	Involved in formation and maintenance of cell shape
SPG_RS10805	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPG_RS10810	COG1122	ATPase activity
SPG_RS10815	COG1122	ATPase activity
SPG_RS10820	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPG_RS10830	COG0612	Peptidase, M16
SPG_RS10835	COG0612	Peptidase, M16
SPG_RS10840	COG2501	S4 domain
SPG_RS10850	COG0517	IMP dehydrogenase activity
SPG_RS10850	COG0516	GMP reductase activity
SPG_RS10855	COG0180	Tryptophanyl-tRNA synthetase
SPG_RS10860	COG0488	(ABC) transporter
SPG_RS10870	COG1511	domain protein
SPG_RS10880	COG1511	domain protein
SPG_RS10925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPG_RS10930	COG1475	DNA binding
SPG_RS10960	COG0582	viral genome integration into host DNA