locus-tag	class	description
SPH_RS00010	COG0592	DNA-directed DNA polymerase activity
SPH_RS00020	COG0012	GTP binding
SPH_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPH_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPH_RS00060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SPH_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPH_RS00215	COG0582	viral genome integration into host DNA
SPH_RS00315	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPH_RS00315	COG5263	repeat protein
SPH_RS00330	COG0582	viral genome integration into host DNA
SPH_RS00345	COG1396	sequence-specific DNA binding
SPH_RS00355	COG3561	AntA/AntB antirepressor
SPH_RS00385	COG0629	single-stranded DNA binding
SPH_RS00570	COG0756	dUTP diphosphatase activity
SPH_RS00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SPH_RS00595	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPH_RS00615	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPH_RS00615	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPH_RS00620	COG1832	CoA-binding protein
SPH_RS00630	COG2855	membrane
SPH_RS00635	COG0436	Aminotransferase
SPH_RS00650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPH_RS00695	COG1134	teichoic acid transport
SPH_RS00695	COG1388	LysM domain
SPH_RS00710	COG2274	protein secretion by the type I secretion system
SPH_RS00715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPH_RS00730	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPH_RS00735	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SPH_RS00745	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPH_RS00760	COG0151	Belongs to the GarS family
SPH_RS00765	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPH_RS00780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPH_RS00785	COG3583	domain protein
SPH_RS00785	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPH_RS00785	COG3064	Membrane
SPH_RS00800	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPH_RS00805	COG3715	PTS system
SPH_RS00810	COG3716	PTS system mannose fructose sorbose family IID component
SPH_RS00820	COG2222	sugar isomerase
SPH_RS00830	COG2514	catechol 2,3-dioxygenase activity
SPH_RS00835	COG1937	Protein conserved in bacteria
SPH_RS00860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPH_RS00865	COG0569	domain protein
SPH_RS00870	COG1215	transferase activity, transferring glycosyl groups
SPH_RS00890	COG5002	protein histidine kinase activity
SPH_RS00915	COG4209	transmembrane transport
SPH_RS00920	COG0395	ABC-type sugar transport system, permease component
SPH_RS00930	COG1653	transport
SPH_RS00960	COG1695	Transcriptional regulator
SPH_RS00980	COG0546	phosphoglycolate phosphatase activity
SPH_RS00985	COG1760	l-serine dehydratase
SPH_RS00990	COG1760	l-serine dehydratase
SPH_RS00995	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPH_RS00995	COG1388	LysM domain
SPH_RS01030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPH_RS01120	COG0494	nUDIX hydrolase
SPH_RS01160	COG1214	PFAM Peptidase M22, glycoprotease
SPH_RS01195	COG0438	transferase activity, transferring glycosyl groups
SPH_RS01225	COG1396	sequence-specific DNA binding
SPH_RS01260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPH_RS01265	COG1464	Belongs to the NlpA lipoprotein family
SPH_RS01270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPH_RS01275	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPH_RS01295	COG2972	Histidine kinase
SPH_RS01300	COG4753	response regulator
SPH_RS01300	COG2207	Transcriptional regulator
SPH_RS01310	COG1780	Probably involved in ribonucleotide reductase function
SPH_RS01345	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPH_RS01345	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPH_RS01365	COG0519	Catalyzes the synthesis of GMP from XMP
SPH_RS01390	COG0582	viral genome integration into host DNA
SPH_RS01465	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPH_RS01470	COG0006	proline dipeptidase activity
SPH_RS01475	COG1393	Belongs to the ArsC family
SPH_RS01500	COG0285	dihydrofolate synthase activity
SPH_RS01510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPH_RS01540	COG0602	queuosine metabolic process
SPH_RS01575	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPH_RS01600	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SPH_RS01640	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SPH_RS01655	COG0201	protein transport
SPH_RS01665	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SPH_RS01670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SPH_RS01680	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SPH_RS01685	COG0202	RNA polymerase activity
SPH_RS01695	COG3830	Belongs to the UPF0237 family
SPH_RS01715	COG1178	ABC-type Fe3 transport system permease component
SPH_RS01720	COG3842	ATPase activity
SPH_RS01755	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPH_RS01760	COG1349	DNA-binding transcription factor activity
SPH_RS01770	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPH_RS01775	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPH_RS01780	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPH_RS01785	COG1882	Formate acetyltransferase
SPH_RS01835	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPH_RS01840	COG4589	Belongs to the CDS family
SPH_RS01845	COG0750	zinc metalloprotease
SPH_RS01855	COG2723	6-phospho-beta-galactosidase activity
SPH_RS01860	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPH_RS01875	COG1523	belongs to the glycosyl hydrolase 13 family
SPH_RS01895	COG2176	DNA-directed DNA polymerase activity
SPH_RS01915	COG2309	aminopeptidase activity
SPH_RS01925	COG1187	pseudouridine synthase activity
SPH_RS01935	COG3579	cysteine-type endopeptidase activity
SPH_RS01940	COG3716	PTS system mannose fructose sorbose family IID component
SPH_RS01945	COG3715	PTS system
SPH_RS01955	COG1064	alcohol dehydrogenase
SPH_RS01960	COG0561	phosphatase activity
SPH_RS01965	COG2252	PERMEase
SPH_RS01980	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SPH_RS01985	COG0285	dihydrofolate synthase activity
SPH_RS01995	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPH_RS01995	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SPH_RS02005	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPH_RS02020	COG1674	ftsk spoiiie
SPH_RS02045	COG1373	ATPase (AAA superfamily
SPH_RS02060	COG0386	Belongs to the glutathione peroxidase family
SPH_RS02065	COG5492	domain, Protein
SPH_RS02090	COG1028	Short-chain dehydrogenase reductase Sdr
SPH_RS02100	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SPH_RS02105	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPH_RS02110	COG3715	PTS system
SPH_RS02115	COG3716	PTS system mannose fructose sorbose family IID component
SPH_RS02130	COG1609	Transcriptional regulator
SPH_RS02160	COG4839	cell division protein FtsL
SPH_RS02165	COG0768	penicillin binding
SPH_RS02190	COG0366	Alpha amylase catalytic
SPH_RS02195	COG4166	transmembrane transport
SPH_RS02215	COG4464	protein tyrosine phosphatase activity
SPH_RS02220	COG3944	biosynthesis protein
SPH_RS02225	COG0489	protein tyrosine kinase activity
SPH_RS02240	COG3475	LICD family
SPH_RS02260	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SPH_RS02265	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SPH_RS02275	COG1088	dTDP-glucose 4,6-dehydratase activity
SPH_RS02280	COG1091	dTDP-4-dehydrorhamnose reductase activity
SPH_RS02305	COG4166	transmembrane transport
SPH_RS02310	COG0366	Alpha amylase catalytic
SPH_RS02315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPH_RS02335	COG0116	Belongs to the methyltransferase superfamily
SPH_RS02345	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SPH_RS02350	COG0745	RESPONSE REGULATOR receiver
SPH_RS02400	COG4585	Histidine kinase
SPH_RS02405	COG2197	response regulator
SPH_RS02440	COG2801	Transposase and inactivated derivatives
SPH_RS02455	COG2213	PTS system mannitol-specific
SPH_RS02460	COG3711	transcriptional antiterminator
SPH_RS02465	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPH_RS02490	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPH_RS02495	COG0681	Belongs to the peptidase S26 family
SPH_RS02520	COG1115	amino acid carrier protein
SPH_RS02545	COG0527	aspartate kinase activity
SPH_RS02550	COG1024	Enoyl-CoA hydratase
SPH_RS02555	COG1846	Transcriptional regulator
SPH_RS02565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPH_RS02575	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPH_RS02580	COG1028	Short-chain dehydrogenase reductase Sdr
SPH_RS02585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPH_RS02600	COG0439	Biotin carboxylase
SPH_RS02605	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPH_RS02665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SPH_RS02675	COG1461	Dihydroxyacetone kinase
SPH_RS02680	COG0028	Belongs to the TPP enzyme family
SPH_RS02685	COG0440	acetolactate synthase activity
SPH_RS02705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SPH_RS02720	COG0765	amino acid transport
SPH_RS02750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPH_RS02755	COG1882	Formate acetyltransferase
SPH_RS02830	COG1846	Transcriptional regulator
SPH_RS02830	COG1940	carbohydrate kinase activity
SPH_RS02835	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPH_RS02845	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPH_RS02850	COG2723	6-phospho-beta-galactosidase activity
SPH_RS02855	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPH_RS02855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPH_RS02860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPH_RS02865	COG0569	domain protein
SPH_RS02885	COG1122	ATPase activity
SPH_RS02900	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPH_RS02905	COG0671	phosphoesterase, PA-phosphatase related
SPH_RS02915	COG1247	-acetyltransferase
SPH_RS02930	COG0504	CTP synthase activity
SPH_RS02935	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPH_RS02955	COG0789	Transcriptional regulator
SPH_RS02960	COG0174	glutamine synthetase
SPH_RS02975	COG4974	Belongs to the 'phage' integrase family
SPH_RS02985	COG0732	type I restriction modification DNA specificity domain
SPH_RS03030	COG0484	heat shock protein binding
SPH_RS03040	COG0537	adenosine 5'-monophosphoramidase activity
SPH_RS03045	COG1131	(ABC) transporter
SPH_RS03070	COG3290	protein histidine kinase activity
SPH_RS03080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPH_RS03085	COG2274	protein secretion by the type I secretion system
SPH_RS03140	COG1266	CAAX protease self-immunity
SPH_RS03160	COG0195	Participates in both transcription termination and antitermination
SPH_RS03165	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPH_RS03230	COG0519	Catalyzes the synthesis of GMP from XMP
SPH_RS03240	COG0525	valine-tRNA ligase activity
SPH_RS03280	COG3711	transcriptional antiterminator
SPH_RS03285	COG2190	(PTS) system
SPH_RS03285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPH_RS03285	COG1263	PTS System
SPH_RS03300	COG0456	acetyltransferase
SPH_RS03305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPH_RS03305	COG0072	phenylalanine-tRNA ligase activity
SPH_RS03320	COG3620	sequence-specific DNA binding
SPH_RS03340	COG1045	serine acetyltransferase
SPH_RS03350	COG0215	cysteine-tRNA ligase activity
SPH_RS03355	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPH_RS03375	COG0577	efflux transmembrane transporter activity
SPH_RS03380	COG1136	(ABC) transporter
SPH_RS03385	COG0577	efflux transmembrane transporter activity
SPH_RS03390	COG0745	RESPONSE REGULATOR receiver
SPH_RS03395	COG5002	protein histidine kinase activity
SPH_RS03400	COG0191	fructose-bisphosphate aldolase activity
SPH_RS03405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SPH_RS03410	COG0765	amino acid transport
SPH_RS03415	COG0765	amino acid transport
SPH_RS03420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPH_RS03430	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPH_RS03430	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPH_RS03470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPH_RS03485	COG1573	uracil-dna glycosylase
SPH_RS03495	COG1114	Component of the transport system for branched-chain amino acids
SPH_RS03500	COG1363	Peptidase, m42
SPH_RS03540	COG4555	ABC transporter
SPH_RS03570	COG1404	Belongs to the peptidase S8 family
SPH_RS03575	COG3335	DDE superfamily endonuclease
SPH_RS03585	COG4372	Transposase
SPH_RS03600	COG3775	system Galactitol-specific IIC component
SPH_RS03605	COG3250	beta-galactosidase activity
SPH_RS03625	COG1242	4 iron, 4 sulfur cluster binding
SPH_RS03630	COG1242	4 iron, 4 sulfur cluster binding
SPH_RS03635	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPH_RS03655	COG0785	Cytochrome C biogenesis protein
SPH_RS03660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPH_RS03665	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPH_RS03665	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPH_RS03670	COG2207	Transcriptional regulator
SPH_RS03670	COG4753	response regulator
SPH_RS03675	COG2972	Histidine kinase
SPH_RS03685	COG3064	Membrane
SPH_RS03690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPH_RS03705	COG1940	carbohydrate kinase activity
SPH_RS03725	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPH_RS03730	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPH_RS03740	COG0300	oxidoreductase activity
SPH_RS03755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPH_RS03765	COG1187	pseudouridine synthase activity
SPH_RS03770	COG1217	gtp-binding protein TYPA
SPH_RS03790	COG1136	(ABC) transporter
SPH_RS03805	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SPH_RS03815	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SPH_RS03840	COG1131	(ABC) transporter
SPH_RS03845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPH_RS03865	COG1304	FMN binding
SPH_RS03890	COG0352	thiamine-phosphate diphosphorylase activity
SPH_RS03900	COG4172	Belongs to the ABC transporter superfamily
SPH_RS03910	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SPH_RS03925	COG0352	thiamine-phosphate diphosphorylase activity
SPH_RS03945	COG2217	Heavy metal translocating P-type atpase
SPH_RS03950	COG0028	Belongs to the TPP enzyme family
SPH_RS03965	COG3335	DDE superfamily endonuclease
SPH_RS03985	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SPH_RS03990	COG4209	transmembrane transport
SPH_RS03995	COG0395	ABC-type sugar transport system, permease component
SPH_RS04035	COG2723	6-phospho-beta-galactosidase activity
SPH_RS04040	COG1482	cell wall glycoprotein biosynthetic process
SPH_RS04045	COG0733	neurotransmitter:sodium symporter activity
SPH_RS04065	COG2081	HI0933 family
SPH_RS04070	COG1307	EDD domain protein, DegV family
SPH_RS04080	COG2131	deaminase
SPH_RS04085	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SPH_RS04125	COG0517	IMP dehydrogenase activity
SPH_RS04125	COG0617	tRNA 3'-terminal CCA addition
SPH_RS04125	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPH_RS04130	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SPH_RS04135	COG2884	Cell division ATP-binding protein ftsE
SPH_RS04140	COG2177	Part of the ABC transporter FtsEX involved in
SPH_RS04145	COG2190	(PTS) system
SPH_RS04145	COG1263	PTS System
SPH_RS04145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPH_RS04155	COG0513	Belongs to the DEAD box helicase family
SPH_RS04165	COG0167	dihydroorotate dehydrogenase activity
SPH_RS04175	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SPH_RS04180	COG4470	Protein conserved in bacteria
SPH_RS04195	COG0488	(ABC) transporter
SPH_RS04220	COG1837	Belongs to the UPF0109 family
SPH_RS04240	COG1328	CTP reductase activity
SPH_RS04240	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPH_RS04250	COG4443	Transcriptional Coactivator p15 (PC4)
SPH_RS04260	COG1268	BioY protein
SPH_RS04265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPH_RS04270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPH_RS04275	COG1136	(ABC) transporter
SPH_RS04280	COG0577	efflux transmembrane transporter activity
SPH_RS04285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPH_RS04285	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPH_RS04310	COG4989	oxidoreductase activity
SPH_RS04320	COG1028	Short-chain dehydrogenase reductase Sdr
SPH_RS04345	COG0745	RESPONSE REGULATOR receiver
SPH_RS04350	COG5002	protein histidine kinase activity
SPH_RS04375	COG0772	Belongs to the SEDS family
SPH_RS04380	COG0693	protein deglycase activity
SPH_RS04390	COG0187	DNA topoisomerase II activity
SPH_RS04405	COG3335	DDE superfamily endonuclease
SPH_RS04415	COG2801	Transposase and inactivated derivatives
SPH_RS04435	COG0494	nUDIX hydrolase
SPH_RS04450	COG0542	response to heat
SPH_RS04455	COG4703	Protein of unknown function (DUF1797)
SPH_RS04460	COG0765	amino acid transport
SPH_RS04465	COG1126	abc transporter atp-binding protein
SPH_RS04470	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPH_RS04475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SPH_RS04495	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SPH_RS04540	COG2813	Specifically methylates the guanine in position
SPH_RS04545	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SPH_RS04555	COG0295	cytidine deaminase activity
SPH_RS04560	COG1744	ABC transporter substrate-binding protein PnrA-like
SPH_RS04565	COG3845	ABC transporter
SPH_RS04570	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPH_RS04575	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPH_RS04590	COG2801	Transposase and inactivated derivatives
SPH_RS04600	COG0187	DNA topoisomerase II activity
SPH_RS04610	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPH_RS04615	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPH_RS04620	COG4166	transmembrane transport
SPH_RS04655	COG0539	negative regulation of cytoplasmic translation
SPH_RS04675	COG1956	GAF domain-containing protein
SPH_RS04680	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPH_RS04695	COG0719	Fe-S assembly protein
SPH_RS04700	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPH_RS04710	COG0719	Fe-S assembly protein
SPH_RS04720	COG1686	Belongs to the peptidase S11 family
SPH_RS04725	COG0628	permease
SPH_RS04735	COG1349	DNA-binding transcription factor activity
SPH_RS04740	COG1105	Belongs to the carbohydrate kinase PfkB family
SPH_RS04745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPH_RS04745	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPH_RS04745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPH_RS04750	COG1674	ftsk spoiiie
SPH_RS04750	COG0697	spore germination
SPH_RS04760	COG1104	cysteine desulfurase activity
SPH_RS04825	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
SPH_RS04835	COG1438	arginine binding
SPH_RS04855	COG0469	pyruvate kinase activity
SPH_RS04860	COG0582	viral genome integration into host DNA
SPH_RS04895	COG3689	TIGRFAM TIGR03943 family protein
SPH_RS04900	COG0701	Predicted permease
SPH_RS04910	COG2183	response to ionizing radiation
SPH_RS04935	COG1136	(ABC) transporter
SPH_RS04940	COG0577	efflux transmembrane transporter activity
SPH_RS04955	COG1982	Orn Lys Arg decarboxylase major
SPH_RS04970	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SPH_RS04990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPH_RS04995	COG0561	phosphatase activity
SPH_RS05015	COG0583	DNA-binding transcription factor activity
SPH_RS05020	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPH_RS05025	COG0564	pseudouridine synthase activity
SPH_RS05030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPH_RS05045	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPH_RS05055	COG0470	DNA polymerase III
SPH_RS05075	COG0528	UMP kinase activity
SPH_RS05085	COG2996	Protein conserved in bacteria
SPH_RS05095	COG1702	phosphate starvation-inducible protein PhoH
SPH_RS05100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPH_RS05105	COG1596	polysaccharide export
SPH_RS05105	COG1555	photosystem II stabilization
SPH_RS05110	COG2333	competence protein COMEC
SPH_RS05110	COG0658	competence protein
SPH_RS05120	COG1131	(ABC) transporter
SPH_RS05150	COG0543	2 iron, 2 sulfur cluster binding
SPH_RS05155	COG0167	dihydroorotate dehydrogenase activity
SPH_RS05160	COG4193	domain, Protein
SPH_RS05160	COG5263	repeat protein
SPH_RS05165	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPH_RS05175	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPH_RS05185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPH_RS05190	COG0237	dephospho-CoA kinase activity
SPH_RS05195	COG2814	Major facilitator Superfamily
SPH_RS05210	COG0557	exoribonuclease II activity
SPH_RS05220	COG0500	methyltransferase
SPH_RS05220	COG3615	Tellurite resistance protein tehB
SPH_RS05235	COG4122	O-methyltransferase activity
SPH_RS05245	COG2801	Transposase and inactivated derivatives
SPH_RS05260	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SPH_RS05280	COG0494	nUDIX hydrolase
SPH_RS05290	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPH_RS05300	COG2176	DNA-directed DNA polymerase activity
SPH_RS05305	COG0584	glycerophosphoryl diester phosphodiesterase
SPH_RS05330	COG0785	Cytochrome C biogenesis protein
SPH_RS05335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPH_RS05340	COG0531	amino acid
SPH_RS05345	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPH_RS05345	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPH_RS05390	COG1970	mechanosensitive ion channel activity
SPH_RS05400	COG4708	membrane
SPH_RS05410	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPH_RS05425	COG1942	4-Oxalocrotonate Tautomerase
SPH_RS05430	COG1435	thymidine kinase activity
SPH_RS05445	COG2890	protein-(glutamine-N5) methyltransferase activity
SPH_RS05470	COG0741	lytic transglycosylase activity
SPH_RS05480	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPH_RS05505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPH_RS05510	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPH_RS05560	COG1597	lipid kinase activity
SPH_RS05565	COG0366	Alpha amylase catalytic
SPH_RS05605	COG0772	Belongs to the SEDS family
SPH_RS05610	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SPH_RS05625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPH_RS05630	COG0358	DNA primase activity
SPH_RS05635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPH_RS05640	COG2151	metal-sulfur cluster biosynthetic enzyme
SPH_RS05645	COG0438	transferase activity, transferring glycosyl groups
SPH_RS05650	COG0438	transferase activity, transferring glycosyl groups
SPH_RS05695	COG4109	DRTGG domain
SPH_RS05700	COG0024	Methionine aminopeptidase
SPH_RS05720	COG0210	DNA helicase
SPH_RS05730	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPH_RS05750	COG1104	cysteine desulfurase activity
SPH_RS05755	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPH_RS05765	COG2357	RelA SpoT domain protein
SPH_RS05775	COG0564	pseudouridine synthase activity
SPH_RS05780	COG0280	phosphate acetyltransferase
SPH_RS05830	COG0196	riboflavin kinase activity
SPH_RS05835	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPH_RS05840	COG1307	EDD domain protein, DegV family
SPH_RS05850	COG0488	(ABC) transporter
SPH_RS05870	COG1523	belongs to the glycosyl hydrolase 13 family
SPH_RS05880	COG1012	belongs to the aldehyde dehydrogenase family
SPH_RS05885	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SPH_RS05895	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SPH_RS05905	COG0560	Phosphoserine phosphatase
SPH_RS05910	COG0560	Phosphoserine phosphatase
SPH_RS05955	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
SPH_RS05955	COG3583	domain protein
SPH_RS05970	COG0270	DNA (cytosine-5-)-methyltransferase activity
SPH_RS06110	COG1396	sequence-specific DNA binding
SPH_RS06115	COG0542	response to heat
SPH_RS06140	COG0135	phosphoribosylanthranilate isomerase activity
SPH_RS06145	COG0366	Alpha amylase catalytic
SPH_RS06160	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPH_RS06180	COG2963	transposase activity
SPH_RS06185	COG2801	Transposase and inactivated derivatives
SPH_RS06190	COG0534	Mate efflux family protein
SPH_RS06200	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPH_RS06205	COG1051	belongs to the nudix hydrolase family
SPH_RS06215	COG1011	Hydrolase
SPH_RS06225	COG1132	(ABC) transporter
SPH_RS06230	COG1131	(ABC) transporter
SPH_RS06240	COG1309	transcriptional regulator
SPH_RS06245	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SPH_RS06250	COG1461	Dihydroxyacetone kinase
SPH_RS06255	COG2376	Dihydroxyacetone kinase
SPH_RS06260	COG1309	transcriptional regulator
SPH_RS06265	COG2376	Dihydroxyacetone kinase
SPH_RS06285	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPH_RS06290	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPH_RS06295	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPH_RS06300	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPH_RS06330	COG3711	transcriptional antiterminator
SPH_RS06335	COG3684	Belongs to the aldolase LacD family
SPH_RS06390	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SPH_RS06395	COG0497	DNA recombination
SPH_RS06400	COG1438	arginine binding
SPH_RS06405	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPH_RS06440	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SPH_RS06460	COG3764	Sortase (surface protein transpeptidase)
SPH_RS06465	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPH_RS06475	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SPH_RS06490	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPH_RS06495	COG5002	protein histidine kinase activity
SPH_RS06500	COG0745	RESPONSE REGULATOR receiver
SPH_RS06505	COG1194	a g-specific adenine glycosylase
SPH_RS06520	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPH_RS06525	COG4684	Psort location CytoplasmicMembrane, score
SPH_RS06535	COG1827	regulation of RNA biosynthetic process
SPH_RS06570	COG0765	amino acid transport
SPH_RS06575	COG1126	abc transporter atp-binding protein
SPH_RS06580	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPH_RS06585	COG0552	protein localization to endoplasmic reticulum
SPH_RS06590	COG0561	phosphatase activity
SPH_RS06595	COG0561	phosphatase activity
SPH_RS06600	COG1196	nuclear chromosome segregation
SPH_RS06625	COG1401	restriction endodeoxyribonuclease activity
SPH_RS06640	COG0066	3-isopropylmalate dehydratase activity
SPH_RS06650	COG0473	3-isopropylmalate dehydrogenase activity
SPH_RS06665	COG3142	Participates in the control of copper homeostasis
SPH_RS06670	COG2832	Protein of unknown function (DUF454)
SPH_RS06675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPH_RS06685	COG0758	DNA mediated transformation
SPH_RS06690	COG4750	Nucleotidyl transferase
SPH_RS06705	COG1063	alcohol dehydrogenase
SPH_RS06720	COG3475	LICD family
SPH_RS06725	COG3475	LICD family
SPH_RS06735	COG0505	Belongs to the CarA family
SPH_RS06750	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPH_RS06765	COG0488	(ABC) transporter
SPH_RS06775	COG1704	LemA family
SPH_RS06825	COG0741	lytic transglycosylase activity
SPH_RS06825	COG0791	NLP P60 protein
SPH_RS06875	COG2946	Replication initiation factor
SPH_RS06880	COG1674	ftsk spoiiie
SPH_RS06900	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPH_RS06915	COG1078	dGTPase activity
SPH_RS06940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPH_RS06945	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPH_RS06950	COG0077	Prephenate dehydratase
SPH_RS06950	COG1605	Chorismate mutase
SPH_RS06955	COG0716	FMN binding
SPH_RS06960	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPH_RS06985	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPH_RS07030	COG2801	Transposase and inactivated derivatives
SPH_RS07075	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPH_RS07080	COG1269	ATP hydrolysis coupled proton transport
SPH_RS07095	COG0673	inositol 2-dehydrogenase activity
SPH_RS07100	COG4409	exo-alpha-(2->6)-sialidase activity
SPH_RS07110	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPH_RS07115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPH_RS07120	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SPH_RS07125	COG1737	Transcriptional regulator
SPH_RS07150	COG1136	(ABC) transporter
SPH_RS07150	COG0577	efflux transmembrane transporter activity
SPH_RS07160	COG0515	serine threonine protein kinase
SPH_RS07185	COG0402	S-adenosylhomocysteine deaminase activity
SPH_RS07195	COG1132	(ABC) transporter
SPH_RS07200	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPH_RS07200	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPH_RS07235	COG1215	transferase activity, transferring glycosyl groups
SPH_RS07245	COG3475	LICD family
SPH_RS07255	COG0077	Prephenate dehydratase
SPH_RS07260	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SPH_RS07275	COG0287	Prephenate dehydrogenase
SPH_RS07300	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPH_RS07310	COG4555	ABC transporter
SPH_RS07350	COG3842	ATPase activity
SPH_RS07365	COG3527	Alpha-acetolactate decarboxylase
SPH_RS07370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPH_RS07375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPH_RS07380	COG0704	Plays a role in the regulation of phosphate uptake
SPH_RS07385	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPH_RS07390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPH_RS07395	COG0581	inorganic phosphate transmembrane transporter activity
SPH_RS07400	COG0573	inorganic phosphate transmembrane transporter activity
SPH_RS07405	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPH_RS07410	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPH_RS07410	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPH_RS07415	COG0483	inositol monophosphate 1-phosphatase activity
SPH_RS07425	COG1393	Belongs to the ArsC family
SPH_RS07435	COG0647	UMP catabolic process
SPH_RS07445	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPH_RS07505	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPH_RS07525	COG1131	(ABC) transporter
SPH_RS07530	COG0826	peptidase U32
SPH_RS07540	COG0826	peptidase U32
SPH_RS07565	COG2188	Transcriptional regulator
SPH_RS07570	COG0697	spore germination
SPH_RS07575	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPH_RS07590	COG0561	phosphatase activity
SPH_RS07625	COG0492	ferredoxin-NADP+ reductase activity
SPH_RS07635	COG1126	abc transporter atp-binding protein
SPH_RS07645	COG1393	Belongs to the ArsC family
SPH_RS07665	COG1272	protein, Hemolysin III
SPH_RS07695	COG1053	succinate dehydrogenase
SPH_RS07695	COG0431	NADPH-dependent FMN reductase
SPH_RS07695	COG3976	FMN-binding domain protein
SPH_RS07720	COG0656	L-ascorbic acid biosynthetic process
SPH_RS07725	COG0726	polysaccharide deacetylase
SPH_RS07745	COG3335	DDE superfamily endonuclease
SPH_RS07765	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPH_RS07805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPH_RS07815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPH_RS07820	COG1126	abc transporter atp-binding protein
SPH_RS07835	COG0628	permease
SPH_RS07840	COG2706	6-phosphogluconolactonase activity
SPH_RS07900	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPH_RS07925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPH_RS07930	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SPH_RS07935	COG0626	cystathionine gamma-synthase activity
SPH_RS07940	COG1132	(ABC) transporter
SPH_RS07950	COG1132	(ABC) transporter
SPH_RS07955	COG4166	transmembrane transport
SPH_RS07960	COG2244	polysaccharide biosynthetic process
SPH_RS07965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPH_RS07970	COG3237	CsbD-like
SPH_RS07995	COG2827	Endonuclease containing a URI domain
SPH_RS08000	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPH_RS08005	COG1098	S1 RNA binding domain
SPH_RS08015	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPH_RS08020	COG0629	single-stranded DNA binding
SPH_RS08030	COG0017	Asparaginyl-tRNA synthetase
SPH_RS08040	COG0436	Aminotransferase
SPH_RS08075	COG0242	peptide deformylase activity
SPH_RS08080	COG0625	glutathione transferase activity
SPH_RS08090	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPH_RS08095	COG0488	(ABC) transporter
SPH_RS08100	COG0617	tRNA 3'-terminal CCA addition
SPH_RS08110	COG1307	EDD domain protein, DegV family
SPH_RS08130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPH_RS08150	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SPH_RS08160	COG0251	oxidation-reduction process
SPH_RS08180	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPH_RS08190	COG5263	repeat protein
SPH_RS08190	COG4193	domain, Protein
SPH_RS08200	COG3935	DnaD domain protein
SPH_RS08215	COG2226	methyltransferase
SPH_RS08225	COG3842	ATPase activity
SPH_RS08235	COG1335	isochorismatase
SPH_RS08245	COG0513	Belongs to the DEAD box helicase family
SPH_RS08250	COG2223	nitrite transmembrane transporter activity
SPH_RS08255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPH_RS08260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPH_RS08265	COG3442	glutamine amidotransferase
SPH_RS08270	COG0006	proline dipeptidase activity
SPH_RS08275	COG2801	Transposase and inactivated derivatives
SPH_RS08280	COG2801	Transposase and inactivated derivatives
SPH_RS08295	COG4720	Psort location CytoplasmicMembrane, score
SPH_RS08300	COG0351	phosphomethylpyrimidine kinase
SPH_RS08325	COG2824	Alkylphosphonate utilization operon protein PhnA
SPH_RS08345	COG0463	Glycosyl transferase, family 2
SPH_RS08350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPH_RS08360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPH_RS08365	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SPH_RS08370	COG2384	SAM-dependent methyltransferase
SPH_RS08385	COG2801	Transposase and inactivated derivatives
SPH_RS08400	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SPH_RS08405	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SPH_RS08410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPH_RS08410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPH_RS08410	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
SPH_RS08415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPH_RS08435	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SPH_RS08440	COG0204	Acyl-transferase
SPH_RS08455	COG2910	NAD(P)H-binding
SPH_RS08475	COG5002	protein histidine kinase activity
SPH_RS08480	COG0745	RESPONSE REGULATOR receiver
SPH_RS08495	COG1959	2 iron, 2 sulfur cluster binding
SPH_RS08545	COG3590	peptidase
SPH_RS08560	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPH_RS08565	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SPH_RS08575	COG1136	(ABC) transporter
SPH_RS08575	COG0577	efflux transmembrane transporter activity
SPH_RS08615	COG3599	regulation of cell shape
SPH_RS08635	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPH_RS08655	COG1051	belongs to the nudix hydrolase family
SPH_RS08660	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPH_RS08675	COG0768	penicillin binding
SPH_RS08690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPH_RS08710	COG2731	YhcH YjgK YiaL family protein
SPH_RS08715	COG0395	ABC-type sugar transport system, permease component
SPH_RS08720	COG1175	transmembrane transport
SPH_RS08735	COG0673	inositol 2-dehydrogenase activity
SPH_RS08745	COG1175	transmembrane transport
SPH_RS08750	COG1653	transport
SPH_RS08775	COG3458	cephalosporin-C deacetylase activity
SPH_RS08780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPH_RS08795	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPH_RS08800	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPH_RS08815	COG1131	(ABC) transporter
SPH_RS08860	COG1484	DNA-dependent DNA replication
SPH_RS08875	COG1725	Transcriptional regulator
SPH_RS08880	COG1131	(ABC) transporter
SPH_RS08890	COG1668	transmembrane transport
SPH_RS08895	COG4152	abc transporter atp-binding protein
SPH_RS08915	COG1940	carbohydrate kinase activity
SPH_RS08920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPH_RS08920	COG2190	(PTS) system
SPH_RS08920	COG1263	PTS System
SPH_RS08930	COG1621	beta-fructofuranosidase activity
SPH_RS08945	COG3425	synthase
SPH_RS08975	COG2815	serine threonine protein kinase
SPH_RS08975	COG0515	serine threonine protein kinase
SPH_RS08980	COG0631	protein serine/threonine phosphatase activity
SPH_RS08985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPH_RS08985	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPH_RS08995	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPH_RS09005	COG0194	GDP metabolic process
SPH_RS09015	COG4115	mRNA cleavage
SPH_RS09030	COG2226	methyltransferase
SPH_RS09035	COG0799	negative regulation of ribosome biogenesis
SPH_RS09045	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPH_RS09050	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SPH_RS09055	COG1534	Rna-binding protein
SPH_RS09060	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPH_RS09075	COG0668	transmembrane transport
SPH_RS09085	COG4129	membrane
SPH_RS09105	COG0438	transferase activity, transferring glycosyl groups
SPH_RS09110	COG0438	transferase activity, transferring glycosyl groups
SPH_RS09115	COG0653	protein targeting
SPH_RS09135	COG0201	protein transport
SPH_RS09140	COG1215	transferase activity, transferring glycosyl groups
SPH_RS09145	COG1442	glycosyl transferase family 8
SPH_RS09150	COG1442	glycosyl transferase family 8
SPH_RS09155	COG1442	glycosyl transferase family 8
SPH_RS09155	COG1216	Glycosyl transferase, family 2
SPH_RS09160	COG1442	glycosyl transferase family 8
SPH_RS09165	COG0438	transferase activity, transferring glycosyl groups
SPH_RS09175	COG1216	Glycosyl transferase, family 2
SPH_RS09175	COG1442	glycosyl transferase family 8
SPH_RS09180	COG1442	glycosyl transferase family 8
SPH_RS09185	COG1216	Glycosyl transferase, family 2
SPH_RS09185	COG1442	glycosyl transferase family 8
SPH_RS09220	COG3118	belongs to the thioredoxin family
SPH_RS09225	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SPH_RS09235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPH_RS09250	COG1164	Oligoendopeptidase f
SPH_RS09255	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPH_RS09265	COG1051	belongs to the nudix hydrolase family
SPH_RS09300	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPH_RS09310	COG1621	beta-fructofuranosidase activity
SPH_RS09315	COG0395	ABC-type sugar transport system, permease component
SPH_RS09320	COG1175	transmembrane transport
SPH_RS09330	COG1609	Transcriptional regulator
SPH_RS09335	COG3711	transcriptional antiterminator
SPH_RS09360	COG3237	CsbD-like
SPH_RS09380	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPH_RS09390	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPH_RS09395	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPH_RS09400	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPH_RS09410	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPH_RS09415	COG1846	Transcriptional regulator
SPH_RS09415	COG1940	carbohydrate kinase activity
SPH_RS09455	COG0512	Glutamine amidotransferase of anthranilate synthase
SPH_RS09460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPH_RS09485	COG1285	pathogenesis
SPH_RS09490	COG1178	ABC-type Fe3 transport system permease component
SPH_RS09515	COG5434	Belongs to the glycosyl hydrolase 28 family
SPH_RS09530	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SPH_RS09535	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPH_RS09540	COG1132	(ABC) transporter
SPH_RS09545	COG1132	(ABC) transporter
SPH_RS09565	COG0708	Exodeoxyribonuclease III
SPH_RS09585	COG2233	PERMEase
SPH_RS09615	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPH_RS09620	COG1609	Transcriptional regulator
SPH_RS09625	COG1063	alcohol dehydrogenase
SPH_RS09630	COG0789	Transcriptional regulator
SPH_RS09635	COG1230	cation diffusion facilitator family transporter
SPH_RS09645	COG3201	nicotinamide mononucleotide transporter
SPH_RS09650	COG1174	glycine betaine transport
SPH_RS09675	COG1363	Peptidase, m42
SPH_RS09690	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPH_RS09695	COG4605	iron ion homeostasis
SPH_RS09700	COG4604	ABC transporter, ATP-binding protein
SPH_RS09705	COG4607	ABC-type enterochelin transport system periplasmic component
SPH_RS09715	COG1187	pseudouridine synthase activity
SPH_RS09735	COG0517	IMP dehydrogenase activity
SPH_RS09745	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SPH_RS09765	COG0366	Alpha amylase catalytic
SPH_RS09770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPH_RS09770	COG1263	PTS System
SPH_RS09775	COG2188	Transcriptional regulator
SPH_RS09795	COG4608	Belongs to the ABC transporter superfamily
SPH_RS09800	COG0444	Belongs to the ABC transporter superfamily
SPH_RS09805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPH_RS09810	COG0601	transmembrane transport
SPH_RS09815	COG4166	transmembrane transport
SPH_RS09825	COG0366	Alpha amylase catalytic
SPH_RS09830	COG0395	ABC-type sugar transport system, permease component
SPH_RS09835	COG1175	transmembrane transport
SPH_RS09840	COG1653	transport
SPH_RS09845	COG3345	alpha-galactosidase
SPH_RS09850	COG2207	Transcriptional regulator
SPH_RS09855	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPH_RS09855	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPH_RS10030	COG4221	oxidoreductase activity
SPH_RS10035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPH_RS10040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPH_RS10075	COG1132	(ABC) transporter
SPH_RS10135	COG3842	ATPase activity
SPH_RS10140	COG1178	ABC-type Fe3 transport system permease component
SPH_RS10145	COG1285	pathogenesis
SPH_RS10205	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPH_RS10205	COG5263	repeat protein
SPH_RS10225	COG1316	TRANSCRIPTIONal
SPH_RS10235	COG0802	atpase or kinase
SPH_RS10265	COG1136	(ABC) transporter
SPH_RS10295	COG1253	flavin adenine dinucleotide binding
SPH_RS10310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPH_RS10320	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPH_RS10330	COG0742	ribosomal rna small subunit methyltransferase
SPH_RS10345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPH_RS10350	COG1254	Belongs to the acylphosphatase family
SPH_RS10360	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPH_RS10370	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPH_RS10385	COG1564	THIamine pyrophosphokinase
SPH_RS10395	COG1162	GTPase activity
SPH_RS10430	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SPH_RS10435	COG0084	hydrolase, TatD family'
SPH_RS10450	COG0436	Aminotransferase
SPH_RS10460	COG0589	response to stress
SPH_RS10465	COG0561	phosphatase activity
SPH_RS10470	COG0252	asparaginase activity
SPH_RS10480	COG1609	Transcriptional regulator
SPH_RS10485	COG2197	response regulator
SPH_RS10490	COG4585	Histidine kinase
SPH_RS10495	COG0842	Transport permease protein
SPH_RS10500	COG1131	(ABC) transporter
SPH_RS10600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPH_RS10605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPH_RS10620	COG0577	efflux transmembrane transporter activity
SPH_RS10640	COG0157	Belongs to the NadC ModD family
SPH_RS10650	COG4133	protoheme IX ABC transporter activity
SPH_RS10655	COG2188	Transcriptional regulator
SPH_RS10660	COG2723	6-phospho-beta-galactosidase activity
SPH_RS10665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPH_RS10675	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPH_RS10680	COG1454	alcohol dehydrogenase
SPH_RS10680	COG1012	belongs to the aldehyde dehydrogenase family
SPH_RS10690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPH_RS10700	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SPH_RS10720	COG3623	hexulose-6-phosphate isomerase
SPH_RS10730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPH_RS10740	COG3037	sugar-specific permease SgaT UlaA
SPH_RS10750	COG1847	R3H domain protein
SPH_RS10755	COG0706	membrane insertase activity
SPH_RS10805	COG4537	Required for transformation and DNA binding
SPH_RS10810	COG1459	type II secretion system
SPH_RS10815	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPH_RS10830	COG1063	alcohol dehydrogenase
SPH_RS10875	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SPH_RS10875	COG0131	Imidazoleglycerol-phosphate dehydratase
SPH_RS10880	COG0534	Mate efflux family protein
SPH_RS10915	COG1674	ftsk spoiiie
SPH_RS10945	COG0582	viral genome integration into host DNA
SPH_RS10960	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SPH_RS11070	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPH_RS11075	COG1132	(ABC) transporter
SPH_RS11085	COG1132	(ABC) transporter
SPH_RS11095	COG1438	arginine binding
SPH_RS11115	COG0745	RESPONSE REGULATOR receiver
SPH_RS11120	COG5002	protein histidine kinase activity
SPH_RS11125	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPH_RS11130	COG0573	inorganic phosphate transmembrane transporter activity
SPH_RS11140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPH_RS11145	COG0704	Plays a role in the regulation of phosphate uptake
SPH_RS11165	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPH_RS11185	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPH_RS11200	COG0697	spore germination
SPH_RS11205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPH_RS11205	COG4499	WXG100 protein secretion system (Wss), protein YukC
SPH_RS11215	COG2217	Heavy metal translocating P-type atpase
SPH_RS11225	COG2226	methyltransferase
SPH_RS11245	COG0058	SHG alpha-glucan phosphorylase activity
SPH_RS11250	COG1640	4-alpha-glucanotransferase
SPH_RS11260	COG2182	Extracellular solute-binding protein
SPH_RS11265	COG1175	transmembrane transport
SPH_RS11270	COG3833	ABC-type maltose transport systems, permease component
SPH_RS11275	COG5521	maltodextrose utilization protein MalA
SPH_RS11280	COG1609	Transcriptional regulator
SPH_RS11285	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPH_RS11320	COG1476	TRANSCRIPTIONal
SPH_RS11350	COG2151	metal-sulfur cluster biosynthetic enzyme
SPH_RS11365	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPH_RS11370	COG3959	Transketolase, thiamine diphosphate binding domain
SPH_RS11385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPH_RS11405	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPH_RS11445	COG0383	alpha-mannosidase activity
SPH_RS11455	COG3537	Alpha-1,2-mannosidase
SPH_RS11475	COG0549	Belongs to the carbamate kinase family
SPH_RS11480	COG1288	antiporter activity
SPH_RS11485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPH_RS11495	COG3064	Membrane
SPH_RS11495	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPH_RS11495	COG3583	domain protein
SPH_RS11510	COG1454	alcohol dehydrogenase
SPH_RS11530	COG3716	PTS system mannose fructose sorbose family IID component
SPH_RS11540	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPH_RS11560	COG1070	Carbohydrate kinase
SPH_RS11570	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPH_RS11570	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPH_RS11575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPH_RS11580	COG1121	(ABC) transporter
SPH_RS11585	COG1846	Transcriptional regulator
SPH_RS11590	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPH_RS11600	COG1696	Membrane protein involved in D-alanine export
SPH_RS11615	COG2211	Major facilitator Superfamily
SPH_RS11620	COG3344	reverse transcriptase
SPH_RS11640	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPH_RS11645	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SPH_RS11665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPH_RS11685	COG0366	Alpha amylase catalytic
SPH_RS11690	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPH_RS11695	COG5002	protein histidine kinase activity
SPH_RS11700	COG0745	RESPONSE REGULATOR receiver
SPH_RS11705	COG0542	response to heat
SPH_RS11710	COG4463	regulation of RNA biosynthetic process
SPH_RS11715	COG1116	anion transmembrane transporter activity
SPH_RS11720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SPH_RS11725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SPH_RS11745	COG0305	Participates in initiation and elongation during chromosome replication
SPH_RS11765	COG1040	competence protein
SPH_RS11770	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPH_RS11775	COG1739	Uncharacterized protein family UPF0029
SPH_RS11795	COG3942	CHAP domain
SPH_RS11805	COG1792	Involved in formation and maintenance of cell shape
SPH_RS11810	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPH_RS11815	COG1122	ATPase activity
SPH_RS11820	COG1122	ATPase activity
SPH_RS11825	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPH_RS11835	COG0612	Peptidase, M16
SPH_RS11840	COG0612	Peptidase, M16
SPH_RS11845	COG2501	S4 domain
SPH_RS11855	COG0517	IMP dehydrogenase activity
SPH_RS11855	COG0516	GMP reductase activity
SPH_RS11860	COG0180	Tryptophanyl-tRNA synthetase
SPH_RS11865	COG0488	(ABC) transporter
SPH_RS11875	COG1511	domain protein
SPH_RS11880	COG1511	domain protein
SPH_RS11925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPH_RS11930	COG1475	DNA binding