locus-tag	class	description
SPNINV200_RS00010	COG0592	DNA-directed DNA polymerase activity
SPNINV200_RS00020	COG0012	GTP binding
SPNINV200_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPNINV200_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPNINV200_RS00060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SPNINV200_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPNINV200_RS00145	COG0756	dUTP diphosphatase activity
SPNINV200_RS00155	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SPNINV200_RS00175	COG2801	Transposase and inactivated derivatives
SPNINV200_RS00185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPNINV200_RS00200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPNINV200_RS00200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPNINV200_RS00205	COG1832	CoA-binding protein
SPNINV200_RS00215	COG2855	membrane
SPNINV200_RS00220	COG0436	Aminotransferase
SPNINV200_RS00235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPNINV200_RS00255	COG2274	protein secretion by the type I secretion system
SPNINV200_RS00260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPNINV200_RS00265	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SPNINV200_RS00270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPNINV200_RS00275	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SPNINV200_RS00285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPNINV200_RS00300	COG0151	Belongs to the GarS family
SPNINV200_RS00305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPNINV200_RS00320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPNINV200_RS00325	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPNINV200_RS00325	COG3064	Membrane
SPNINV200_RS00325	COG3583	domain protein
SPNINV200_RS00340	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPNINV200_RS00345	COG3715	PTS system
SPNINV200_RS00350	COG3716	PTS system mannose fructose sorbose family IID component
SPNINV200_RS00365	COG2222	sugar isomerase
SPNINV200_RS00375	COG2514	catechol 2,3-dioxygenase activity
SPNINV200_RS00380	COG1937	Protein conserved in bacteria
SPNINV200_RS00405	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPNINV200_RS00410	COG0569	domain protein
SPNINV200_RS00415	COG1215	transferase activity, transferring glycosyl groups
SPNINV200_RS00435	COG5002	protein histidine kinase activity
SPNINV200_RS00455	COG4209	transmembrane transport
SPNINV200_RS00460	COG0395	ABC-type sugar transport system, permease component
SPNINV200_RS00465	COG1653	transport
SPNINV200_RS00495	COG1695	Transcriptional regulator
SPNINV200_RS00520	COG0546	phosphoglycolate phosphatase activity
SPNINV200_RS00525	COG1760	l-serine dehydratase
SPNINV200_RS00530	COG1760	l-serine dehydratase
SPNINV200_RS00560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPNINV200_RS00565	COG0137	argininosuccinate synthase activity
SPNINV200_RS00655	COG0494	nUDIX hydrolase
SPNINV200_RS00660	COG0445	tRNA wobble uridine modification
SPNINV200_RS00685	COG1214	PFAM Peptidase M22, glycoprotease
SPNINV200_RS00725	COG0438	transferase activity, transferring glycosyl groups
SPNINV200_RS00760	COG1396	sequence-specific DNA binding
SPNINV200_RS00810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPNINV200_RS00820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPNINV200_RS00825	COG1464	Belongs to the NlpA lipoprotein family
SPNINV200_RS00830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPNINV200_RS00835	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPNINV200_RS00855	COG2972	Histidine kinase
SPNINV200_RS00860	COG2207	Transcriptional regulator
SPNINV200_RS00860	COG4753	response regulator
SPNINV200_RS00870	COG1780	Probably involved in ribonucleotide reductase function
SPNINV200_RS00905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPNINV200_RS00905	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPNINV200_RS00925	COG2818	Glycosylase
SPNINV200_RS00950	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPNINV200_RS00955	COG0006	proline dipeptidase activity
SPNINV200_RS00960	COG1393	Belongs to the ArsC family
SPNINV200_RS00985	COG0285	dihydrofolate synthase activity
SPNINV200_RS00995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPNINV200_RS01060	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPNINV200_RS01085	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SPNINV200_RS01115	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SPNINV200_RS01125	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SPNINV200_RS01140	COG0201	protein transport
SPNINV200_RS01150	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SPNINV200_RS01155	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SPNINV200_RS01165	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SPNINV200_RS01170	COG0202	RNA polymerase activity
SPNINV200_RS01180	COG3830	Belongs to the UPF0237 family
SPNINV200_RS01205	COG3842	ATPase activity
SPNINV200_RS01225	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPNINV200_RS01230	COG1349	DNA-binding transcription factor activity
SPNINV200_RS01240	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPNINV200_RS01245	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPNINV200_RS01250	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPNINV200_RS01255	COG1882	Formate acetyltransferase
SPNINV200_RS01300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPNINV200_RS01305	COG4589	Belongs to the CDS family
SPNINV200_RS01310	COG0750	zinc metalloprotease
SPNINV200_RS01320	COG2723	6-phospho-beta-galactosidase activity
SPNINV200_RS01325	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPNINV200_RS01340	COG1523	belongs to the glycosyl hydrolase 13 family
SPNINV200_RS01365	COG2176	DNA-directed DNA polymerase activity
SPNINV200_RS01385	COG2309	aminopeptidase activity
SPNINV200_RS01390	COG2261	transglycosylase associated protein
SPNINV200_RS01400	COG1187	pseudouridine synthase activity
SPNINV200_RS01410	COG3579	cysteine-type endopeptidase activity
SPNINV200_RS01415	COG3716	PTS system mannose fructose sorbose family IID component
SPNINV200_RS01420	COG3715	PTS system
SPNINV200_RS01430	COG1064	alcohol dehydrogenase
SPNINV200_RS01435	COG0561	phosphatase activity
SPNINV200_RS01440	COG2252	PERMEase
SPNINV200_RS01450	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SPNINV200_RS01455	COG0285	dihydrofolate synthase activity
SPNINV200_RS01465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SPNINV200_RS01465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPNINV200_RS01475	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPNINV200_RS01500	COG0386	Belongs to the glutathione peroxidase family
SPNINV200_RS01505	COG5492	domain, Protein
SPNINV200_RS01530	COG1028	Short-chain dehydrogenase reductase Sdr
SPNINV200_RS01540	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SPNINV200_RS01545	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPNINV200_RS01550	COG3715	PTS system
SPNINV200_RS01555	COG3716	PTS system mannose fructose sorbose family IID component
SPNINV200_RS01570	COG1609	Transcriptional regulator
SPNINV200_RS01600	COG4839	cell division protein FtsL
SPNINV200_RS01605	COG0768	penicillin binding
SPNINV200_RS01640	COG0366	Alpha amylase catalytic
SPNINV200_RS01680	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SPNINV200_RS01695	COG1216	Glycosyl transferase, family 2
SPNINV200_RS01700	COG1442	glycosyl transferase family 8
SPNINV200_RS01700	COG1216	Glycosyl transferase, family 2
SPNINV200_RS01720	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SPNINV200_RS01750	COG4166	transmembrane transport
SPNINV200_RS01755	COG0366	Alpha amylase catalytic
SPNINV200_RS01760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPNINV200_RS01785	COG0116	Belongs to the methyltransferase superfamily
SPNINV200_RS01795	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SPNINV200_RS01800	COG0745	RESPONSE REGULATOR receiver
SPNINV200_RS01850	COG4585	Histidine kinase
SPNINV200_RS01855	COG2197	response regulator
SPNINV200_RS01890	COG2801	Transposase and inactivated derivatives
SPNINV200_RS01910	COG2213	PTS system mannitol-specific
SPNINV200_RS01915	COG3711	transcriptional antiterminator
SPNINV200_RS01920	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPNINV200_RS01945	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPNINV200_RS01950	COG0681	Belongs to the peptidase S26 family
SPNINV200_RS01975	COG1115	amino acid carrier protein
SPNINV200_RS02000	COG0527	aspartate kinase activity
SPNINV200_RS02005	COG1024	Enoyl-CoA hydratase
SPNINV200_RS02010	COG1846	Transcriptional regulator
SPNINV200_RS02020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPNINV200_RS02030	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPNINV200_RS02035	COG1028	Short-chain dehydrogenase reductase Sdr
SPNINV200_RS02040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPNINV200_RS02055	COG0439	Biotin carboxylase
SPNINV200_RS02060	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPNINV200_RS02130	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SPNINV200_RS02140	COG1461	Dihydroxyacetone kinase
SPNINV200_RS02145	COG0028	Belongs to the TPP enzyme family
SPNINV200_RS02150	COG0440	acetolactate synthase activity
SPNINV200_RS02170	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SPNINV200_RS02185	COG0765	amino acid transport
SPNINV200_RS02225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPNINV200_RS02230	COG1882	Formate acetyltransferase
SPNINV200_RS02265	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPNINV200_RS02270	COG0569	domain protein
SPNINV200_RS02290	COG1122	ATPase activity
SPNINV200_RS02305	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPNINV200_RS02310	COG0671	phosphoesterase, PA-phosphatase related
SPNINV200_RS02320	COG1247	-acetyltransferase
SPNINV200_RS02335	COG0504	CTP synthase activity
SPNINV200_RS02340	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPNINV200_RS02360	COG0789	Transcriptional regulator
SPNINV200_RS02365	COG0174	glutamine synthetase
SPNINV200_RS02380	COG4974	Belongs to the 'phage' integrase family
SPNINV200_RS02390	COG0732	type I restriction modification DNA specificity domain
SPNINV200_RS02435	COG0484	heat shock protein binding
SPNINV200_RS02450	COG0537	adenosine 5'-monophosphoramidase activity
SPNINV200_RS02455	COG1131	(ABC) transporter
SPNINV200_RS02480	COG3290	protein histidine kinase activity
SPNINV200_RS02490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPNINV200_RS02495	COG2274	protein secretion by the type I secretion system
SPNINV200_RS02575	COG1266	CAAX protease self-immunity
SPNINV200_RS02595	COG0195	Participates in both transcription termination and antitermination
SPNINV200_RS02600	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPNINV200_RS02665	COG0519	Catalyzes the synthesis of GMP from XMP
SPNINV200_RS02675	COG0525	valine-tRNA ligase activity
SPNINV200_RS02695	COG2801	Transposase and inactivated derivatives
SPNINV200_RS02735	COG3711	transcriptional antiterminator
SPNINV200_RS02740	COG2190	(PTS) system
SPNINV200_RS02740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPNINV200_RS02740	COG1263	PTS System
SPNINV200_RS02755	COG0456	acetyltransferase
SPNINV200_RS02760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPNINV200_RS02760	COG0072	phenylalanine-tRNA ligase activity
SPNINV200_RS02775	COG3620	sequence-specific DNA binding
SPNINV200_RS02780	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SPNINV200_RS02795	COG1045	serine acetyltransferase
SPNINV200_RS02805	COG0215	cysteine-tRNA ligase activity
SPNINV200_RS02810	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPNINV200_RS02830	COG0577	efflux transmembrane transporter activity
SPNINV200_RS02835	COG1136	(ABC) transporter
SPNINV200_RS02845	COG0745	RESPONSE REGULATOR receiver
SPNINV200_RS02850	COG5002	protein histidine kinase activity
SPNINV200_RS02855	COG0191	fructose-bisphosphate aldolase activity
SPNINV200_RS02860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SPNINV200_RS02865	COG0765	amino acid transport
SPNINV200_RS02870	COG0765	amino acid transport
SPNINV200_RS02875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPNINV200_RS02885	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPNINV200_RS02885	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPNINV200_RS02925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPNINV200_RS02940	COG1573	uracil-dna glycosylase
SPNINV200_RS02950	COG1114	Component of the transport system for branched-chain amino acids
SPNINV200_RS02955	COG1363	Peptidase, m42
SPNINV200_RS02995	COG4555	ABC transporter
SPNINV200_RS03025	COG1404	Belongs to the peptidase S8 family
SPNINV200_RS03040	COG3775	system Galactitol-specific IIC component
SPNINV200_RS03050	COG3250	beta-galactosidase activity
SPNINV200_RS03070	COG1242	4 iron, 4 sulfur cluster binding
SPNINV200_RS03075	COG1242	4 iron, 4 sulfur cluster binding
SPNINV200_RS03080	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPNINV200_RS03105	COG0785	Cytochrome C biogenesis protein
SPNINV200_RS03110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPNINV200_RS03115	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPNINV200_RS03115	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPNINV200_RS03120	COG4753	response regulator
SPNINV200_RS03120	COG2207	Transcriptional regulator
SPNINV200_RS03125	COG2972	Histidine kinase
SPNINV200_RS03135	COG3064	Membrane
SPNINV200_RS03140	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPNINV200_RS03155	COG1940	carbohydrate kinase activity
SPNINV200_RS03175	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPNINV200_RS03180	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPNINV200_RS03190	COG0300	oxidoreductase activity
SPNINV200_RS03205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPNINV200_RS03215	COG1187	pseudouridine synthase activity
SPNINV200_RS03220	COG1217	gtp-binding protein TYPA
SPNINV200_RS03240	COG1136	(ABC) transporter
SPNINV200_RS03255	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SPNINV200_RS03290	COG2826	transposase and inactivated derivatives, IS30 family
SPNINV200_RS03300	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SPNINV200_RS03325	COG1131	(ABC) transporter
SPNINV200_RS03330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPNINV200_RS03340	COG1126	abc transporter atp-binding protein
SPNINV200_RS03345	COG1126	abc transporter atp-binding protein
SPNINV200_RS03350	COG0765	amino acid transport
SPNINV200_RS03360	COG1304	FMN binding
SPNINV200_RS03370	COG1304	FMN binding
SPNINV200_RS03380	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SPNINV200_RS03385	COG0352	thiamine-phosphate diphosphorylase activity
SPNINV200_RS03395	COG4172	Belongs to the ABC transporter superfamily
SPNINV200_RS03405	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SPNINV200_RS03415	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SPNINV200_RS03420	COG0352	thiamine-phosphate diphosphorylase activity
SPNINV200_RS03440	COG2217	Heavy metal translocating P-type atpase
SPNINV200_RS03445	COG0028	Belongs to the TPP enzyme family
SPNINV200_RS03455	COG3335	DDE superfamily endonuclease
SPNINV200_RS03465	COG2723	6-phospho-beta-galactosidase activity
SPNINV200_RS03470	COG1482	cell wall glycoprotein biosynthetic process
SPNINV200_RS03475	COG0733	neurotransmitter:sodium symporter activity
SPNINV200_RS03485	COG0789	Transcriptional regulator
SPNINV200_RS03495	COG2081	HI0933 family
SPNINV200_RS03500	COG1307	EDD domain protein, DegV family
SPNINV200_RS03510	COG2131	deaminase
SPNINV200_RS03515	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SPNINV200_RS03555	COG0617	tRNA 3'-terminal CCA addition
SPNINV200_RS03555	COG0517	IMP dehydrogenase activity
SPNINV200_RS03555	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPNINV200_RS03560	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SPNINV200_RS03565	COG2884	Cell division ATP-binding protein ftsE
SPNINV200_RS03570	COG2177	Part of the ABC transporter FtsEX involved in
SPNINV200_RS03575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPNINV200_RS03575	COG1263	PTS System
SPNINV200_RS03575	COG2190	(PTS) system
SPNINV200_RS03585	COG0513	Belongs to the DEAD box helicase family
SPNINV200_RS03595	COG0167	dihydroorotate dehydrogenase activity
SPNINV200_RS03605	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SPNINV200_RS03610	COG4470	Protein conserved in bacteria
SPNINV200_RS03615	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SPNINV200_RS03625	COG0488	(ABC) transporter
SPNINV200_RS03650	COG1837	Belongs to the UPF0109 family
SPNINV200_RS03670	COG1328	CTP reductase activity
SPNINV200_RS03670	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPNINV200_RS03680	COG4443	Transcriptional Coactivator p15 (PC4)
SPNINV200_RS03690	COG1268	BioY protein
SPNINV200_RS03695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPNINV200_RS03700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPNINV200_RS03705	COG1136	(ABC) transporter
SPNINV200_RS03710	COG0577	efflux transmembrane transporter activity
SPNINV200_RS03715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPNINV200_RS03715	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPNINV200_RS03735	COG4989	oxidoreductase activity
SPNINV200_RS03745	COG1028	Short-chain dehydrogenase reductase Sdr
SPNINV200_RS03770	COG0745	RESPONSE REGULATOR receiver
SPNINV200_RS03775	COG5002	protein histidine kinase activity
SPNINV200_RS03800	COG0772	Belongs to the SEDS family
SPNINV200_RS03805	COG0693	protein deglycase activity
SPNINV200_RS03815	COG0187	DNA topoisomerase II activity
SPNINV200_RS03835	COG0494	nUDIX hydrolase
SPNINV200_RS03855	COG0542	response to heat
SPNINV200_RS03860	COG4703	Protein of unknown function (DUF1797)
SPNINV200_RS03865	COG0765	amino acid transport
SPNINV200_RS03870	COG1126	abc transporter atp-binding protein
SPNINV200_RS03875	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPNINV200_RS03885	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SPNINV200_RS03905	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SPNINV200_RS03950	COG2813	Specifically methylates the guanine in position
SPNINV200_RS03955	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SPNINV200_RS03965	COG0295	cytidine deaminase activity
SPNINV200_RS03970	COG1744	ABC transporter substrate-binding protein PnrA-like
SPNINV200_RS03975	COG3845	ABC transporter
SPNINV200_RS03980	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPNINV200_RS03985	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPNINV200_RS04005	COG2801	Transposase and inactivated derivatives
SPNINV200_RS04015	COG0187	DNA topoisomerase II activity
SPNINV200_RS04025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPNINV200_RS04030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPNINV200_RS04035	COG4166	transmembrane transport
SPNINV200_RS04070	COG0539	negative regulation of cytoplasmic translation
SPNINV200_RS04090	COG1956	GAF domain-containing protein
SPNINV200_RS04095	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPNINV200_RS04110	COG0719	Fe-S assembly protein
SPNINV200_RS04115	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPNINV200_RS04125	COG0719	Fe-S assembly protein
SPNINV200_RS04135	COG1686	Belongs to the peptidase S11 family
SPNINV200_RS04140	COG0628	permease
SPNINV200_RS04165	COG1349	DNA-binding transcription factor activity
SPNINV200_RS04170	COG1105	Belongs to the carbohydrate kinase PfkB family
SPNINV200_RS04175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPNINV200_RS04175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPNINV200_RS04175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPNINV200_RS04180	COG0697	spore germination
SPNINV200_RS04180	COG1674	ftsk spoiiie
SPNINV200_RS04190	COG1104	cysteine desulfurase activity
SPNINV200_RS04250	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
SPNINV200_RS04280	COG1737	Transcriptional regulator
SPNINV200_RS04285	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SPNINV200_RS04290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPNINV200_RS04295	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPNINV200_RS04305	COG4409	exo-alpha-(2->6)-sialidase activity
SPNINV200_RS04310	COG0673	inositol 2-dehydrogenase activity
SPNINV200_RS04325	COG1269	ATP hydrolysis coupled proton transport
SPNINV200_RS04330	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPNINV200_RS04385	COG1438	arginine binding
SPNINV200_RS04405	COG0469	pyruvate kinase activity
SPNINV200_RS04415	COG0582	viral genome integration into host DNA
SPNINV200_RS04450	COG3689	TIGRFAM TIGR03943 family protein
SPNINV200_RS04455	COG0701	Predicted permease
SPNINV200_RS04465	COG3955	Domain of unknown function (DUF1919)
SPNINV200_RS04470	COG2183	response to ionizing radiation
SPNINV200_RS04490	COG1136	(ABC) transporter
SPNINV200_RS04495	COG0577	efflux transmembrane transporter activity
SPNINV200_RS04510	COG1982	Orn Lys Arg decarboxylase major
SPNINV200_RS04525	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SPNINV200_RS04545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPNINV200_RS04550	COG0561	phosphatase activity
SPNINV200_RS04570	COG0583	DNA-binding transcription factor activity
SPNINV200_RS04575	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPNINV200_RS04580	COG0564	pseudouridine synthase activity
SPNINV200_RS04585	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPNINV200_RS04600	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPNINV200_RS04610	COG0470	DNA polymerase III
SPNINV200_RS04630	COG0528	UMP kinase activity
SPNINV200_RS04640	COG2996	Protein conserved in bacteria
SPNINV200_RS04650	COG1702	phosphate starvation-inducible protein PhoH
SPNINV200_RS04655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPNINV200_RS04660	COG1596	polysaccharide export
SPNINV200_RS04660	COG1555	photosystem II stabilization
SPNINV200_RS04665	COG2333	competence protein COMEC
SPNINV200_RS04665	COG0658	competence protein
SPNINV200_RS04690	COG0488	(ABC) transporter
SPNINV200_RS04735	COG0543	2 iron, 2 sulfur cluster binding
SPNINV200_RS04740	COG0167	dihydroorotate dehydrogenase activity
SPNINV200_RS04745	COG4193	domain, Protein
SPNINV200_RS04745	COG5263	repeat protein
SPNINV200_RS04750	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPNINV200_RS04760	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPNINV200_RS04770	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPNINV200_RS04775	COG0237	dephospho-CoA kinase activity
SPNINV200_RS04780	COG2814	Major facilitator Superfamily
SPNINV200_RS04785	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPNINV200_RS04795	COG0557	exoribonuclease II activity
SPNINV200_RS04805	COG0500	methyltransferase
SPNINV200_RS04805	COG3615	Tellurite resistance protein tehB
SPNINV200_RS04820	COG4122	O-methyltransferase activity
SPNINV200_RS04830	COG2801	Transposase and inactivated derivatives
SPNINV200_RS04845	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SPNINV200_RS04865	COG0494	nUDIX hydrolase
SPNINV200_RS04875	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPNINV200_RS04885	COG2176	DNA-directed DNA polymerase activity
SPNINV200_RS04890	COG0584	glycerophosphoryl diester phosphodiesterase
SPNINV200_RS04910	COG0785	Cytochrome C biogenesis protein
SPNINV200_RS04915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPNINV200_RS04920	COG0531	amino acid
SPNINV200_RS04925	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPNINV200_RS04925	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPNINV200_RS04975	COG1970	mechanosensitive ion channel activity
SPNINV200_RS04985	COG4708	membrane
SPNINV200_RS05000	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPNINV200_RS05010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SPNINV200_RS05015	COG1942	4-Oxalocrotonate Tautomerase
SPNINV200_RS05020	COG1435	thymidine kinase activity
SPNINV200_RS05030	COG2890	protein-(glutamine-N5) methyltransferase activity
SPNINV200_RS05055	COG0741	lytic transglycosylase activity
SPNINV200_RS05065	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPNINV200_RS05080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPNINV200_RS05085	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPNINV200_RS05145	COG1597	lipid kinase activity
SPNINV200_RS05165	COG1396	sequence-specific DNA binding
SPNINV200_RS05170	COG0542	response to heat
SPNINV200_RS05175	COG0613	PHP domain protein
SPNINV200_RS05180	COG0613	PHP domain protein
SPNINV200_RS05185	COG1196	nuclear chromosome segregation
SPNINV200_RS05200	COG3843	relaxase mobilization nuclease domain protein
SPNINV200_RS05230	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPNINV200_RS05235	COG2832	Protein of unknown function (DUF454)
SPNINV200_RS05240	COG3142	Participates in the control of copper homeostasis
SPNINV200_RS05260	COG0473	3-isopropylmalate dehydrogenase activity
SPNINV200_RS05270	COG0066	3-isopropylmalate dehydratase activity
SPNINV200_RS05285	COG1401	restriction endodeoxyribonuclease activity
SPNINV200_RS05310	COG1196	nuclear chromosome segregation
SPNINV200_RS05315	COG0561	phosphatase activity
SPNINV200_RS05320	COG0561	phosphatase activity
SPNINV200_RS05325	COG0552	protein localization to endoplasmic reticulum
SPNINV200_RS05330	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPNINV200_RS05335	COG1126	abc transporter atp-binding protein
SPNINV200_RS05340	COG0765	amino acid transport
SPNINV200_RS05370	COG1827	regulation of RNA biosynthetic process
SPNINV200_RS05380	COG4684	Psort location CytoplasmicMembrane, score
SPNINV200_RS05385	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPNINV200_RS05400	COG1194	a g-specific adenine glycosylase
SPNINV200_RS05405	COG0745	RESPONSE REGULATOR receiver
SPNINV200_RS05410	COG5002	protein histidine kinase activity
SPNINV200_RS05415	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPNINV200_RS05440	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPNINV200_RS05445	COG3764	Sortase (surface protein transpeptidase)
SPNINV200_RS05470	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SPNINV200_RS05505	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPNINV200_RS05510	COG1438	arginine binding
SPNINV200_RS05515	COG0497	DNA recombination
SPNINV200_RS05520	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SPNINV200_RS05575	COG3684	Belongs to the aldolase LacD family
SPNINV200_RS05580	COG3711	transcriptional antiterminator
SPNINV200_RS05595	COG2723	6-phospho-beta-galactosidase activity
SPNINV200_RS05620	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPNINV200_RS05625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPNINV200_RS05630	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPNINV200_RS05635	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPNINV200_RS05650	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SPNINV200_RS05655	COG1011	Hydrolase
SPNINV200_RS05670	COG1051	belongs to the nudix hydrolase family
SPNINV200_RS05675	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPNINV200_RS05685	COG0534	Mate efflux family protein
SPNINV200_RS05690	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPNINV200_RS05695	COG0022	dehydrogenase e1 component
SPNINV200_RS05700	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPNINV200_RS05705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPNINV200_RS05710	COG0095	Lipoate-protein ligase
SPNINV200_RS05730	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPNINV200_RS05735	COG3064	Membrane
SPNINV200_RS05740	COG3583	domain protein
SPNINV200_RS05740	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
SPNINV200_RS05805	COG0560	Phosphoserine phosphatase
SPNINV200_RS05815	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SPNINV200_RS05825	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SPNINV200_RS05830	COG1012	belongs to the aldehyde dehydrogenase family
SPNINV200_RS05845	COG1523	belongs to the glycosyl hydrolase 13 family
SPNINV200_RS05865	COG0488	(ABC) transporter
SPNINV200_RS05875	COG1307	EDD domain protein, DegV family
SPNINV200_RS05880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPNINV200_RS05885	COG0196	riboflavin kinase activity
SPNINV200_RS05920	COG0280	phosphate acetyltransferase
SPNINV200_RS05925	COG0564	pseudouridine synthase activity
SPNINV200_RS05935	COG2357	RelA SpoT domain protein
SPNINV200_RS05945	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPNINV200_RS05950	COG1104	cysteine desulfurase activity
SPNINV200_RS05970	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPNINV200_RS05980	COG0210	DNA helicase
SPNINV200_RS06000	COG0024	Methionine aminopeptidase
SPNINV200_RS06005	COG4109	DRTGG domain
SPNINV200_RS06015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPNINV200_RS06055	COG0438	transferase activity, transferring glycosyl groups
SPNINV200_RS06060	COG0438	transferase activity, transferring glycosyl groups
SPNINV200_RS06065	COG2151	metal-sulfur cluster biosynthetic enzyme
SPNINV200_RS06070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPNINV200_RS06075	COG0358	DNA primase activity
SPNINV200_RS06095	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SPNINV200_RS06100	COG0772	Belongs to the SEDS family
SPNINV200_RS06125	COG1396	sequence-specific DNA binding
SPNINV200_RS06185	COG0758	DNA mediated transformation
SPNINV200_RS06190	COG4750	Nucleotidyl transferase
SPNINV200_RS06205	COG1063	alcohol dehydrogenase
SPNINV200_RS06220	COG3475	LICD family
SPNINV200_RS06225	COG3475	LICD family
SPNINV200_RS06235	COG0505	Belongs to the CarA family
SPNINV200_RS06250	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPNINV200_RS06265	COG0488	(ABC) transporter
SPNINV200_RS06275	COG1704	LemA family
SPNINV200_RS06290	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPNINV200_RS06305	COG1078	dGTPase activity
SPNINV200_RS06330	COG1396	sequence-specific DNA binding
SPNINV200_RS06345	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPNINV200_RS06350	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPNINV200_RS06355	COG1605	Chorismate mutase
SPNINV200_RS06355	COG0077	Prephenate dehydratase
SPNINV200_RS06360	COG0716	FMN binding
SPNINV200_RS06365	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPNINV200_RS06380	COG2837	iron assimilation
SPNINV200_RS06395	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPNINV200_RS06415	COG0402	S-adenosylhomocysteine deaminase activity
SPNINV200_RS06425	COG1132	(ABC) transporter
SPNINV200_RS06430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPNINV200_RS06430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPNINV200_RS06465	COG1215	transferase activity, transferring glycosyl groups
SPNINV200_RS06475	COG3475	LICD family
SPNINV200_RS06485	COG0077	Prephenate dehydratase
SPNINV200_RS06490	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SPNINV200_RS06505	COG0287	Prephenate dehydrogenase
SPNINV200_RS06530	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPNINV200_RS06545	COG1131	(ABC) transporter
SPNINV200_RS06585	COG3842	ATPase activity
SPNINV200_RS06600	COG3527	Alpha-acetolactate decarboxylase
SPNINV200_RS06605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPNINV200_RS06610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPNINV200_RS06615	COG0704	Plays a role in the regulation of phosphate uptake
SPNINV200_RS06620	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPNINV200_RS06625	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPNINV200_RS06630	COG0581	inorganic phosphate transmembrane transporter activity
SPNINV200_RS06635	COG0573	inorganic phosphate transmembrane transporter activity
SPNINV200_RS06640	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPNINV200_RS06645	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPNINV200_RS06645	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPNINV200_RS06650	COG0483	inositol monophosphate 1-phosphatase activity
SPNINV200_RS06660	COG1393	Belongs to the ArsC family
SPNINV200_RS06670	COG0647	UMP catabolic process
SPNINV200_RS06680	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPNINV200_RS06730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPNINV200_RS06740	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPNINV200_RS06765	COG1131	(ABC) transporter
SPNINV200_RS06775	COG0826	peptidase U32
SPNINV200_RS06785	COG0826	peptidase U32
SPNINV200_RS06815	COG1132	(ABC) transporter
SPNINV200_RS06830	COG1129	ABC transporter
SPNINV200_RS06875	COG2188	Transcriptional regulator
SPNINV200_RS06880	COG0697	spore germination
SPNINV200_RS06885	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPNINV200_RS06900	COG0561	phosphatase activity
SPNINV200_RS06930	COG0492	ferredoxin-NADP+ reductase activity
SPNINV200_RS06940	COG1126	abc transporter atp-binding protein
SPNINV200_RS06950	COG1393	Belongs to the ArsC family
SPNINV200_RS06955	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SPNINV200_RS06970	COG1272	protein, Hemolysin III
SPNINV200_RS06980	COG0577	efflux transmembrane transporter activity
SPNINV200_RS06980	COG1136	(ABC) transporter
SPNINV200_RS07015	COG0431	NADPH-dependent FMN reductase
SPNINV200_RS07015	COG3976	FMN-binding domain protein
SPNINV200_RS07015	COG1053	succinate dehydrogenase
SPNINV200_RS07025	COG0751	glycine-tRNA ligase activity
SPNINV200_RS07040	COG0656	L-ascorbic acid biosynthetic process
SPNINV200_RS07045	COG0726	polysaccharide deacetylase
SPNINV200_RS07060	COG0513	Belongs to the DEAD box helicase family
SPNINV200_RS07065	COG3335	DDE superfamily endonuclease
SPNINV200_RS07070	COG3335	DDE superfamily endonuclease
SPNINV200_RS07090	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPNINV200_RS07125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPNINV200_RS07150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPNINV200_RS07155	COG1126	abc transporter atp-binding protein
SPNINV200_RS07170	COG0628	permease
SPNINV200_RS07175	COG2706	6-phosphogluconolactonase activity
SPNINV200_RS07235	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPNINV200_RS07260	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPNINV200_RS07265	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SPNINV200_RS07270	COG0626	cystathionine gamma-synthase activity
SPNINV200_RS07275	COG1132	(ABC) transporter
SPNINV200_RS07280	COG1132	(ABC) transporter
SPNINV200_RS07285	COG4166	transmembrane transport
SPNINV200_RS07290	COG2244	polysaccharide biosynthetic process
SPNINV200_RS07295	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPNINV200_RS07320	COG2827	Endonuclease containing a URI domain
SPNINV200_RS07325	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPNINV200_RS07330	COG1098	S1 RNA binding domain
SPNINV200_RS07340	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPNINV200_RS07345	COG0629	single-stranded DNA binding
SPNINV200_RS07355	COG0017	Asparaginyl-tRNA synthetase
SPNINV200_RS07365	COG0436	Aminotransferase
SPNINV200_RS07400	COG0242	peptide deformylase activity
SPNINV200_RS07405	COG0625	glutathione transferase activity
SPNINV200_RS07415	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPNINV200_RS07420	COG0488	(ABC) transporter
SPNINV200_RS07435	COG1307	EDD domain protein, DegV family
SPNINV200_RS07455	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPNINV200_RS07470	COG1481	regulation of sporulation
SPNINV200_RS07475	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SPNINV200_RS07485	COG0251	oxidation-reduction process
SPNINV200_RS07505	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPNINV200_RS07515	COG5263	repeat protein
SPNINV200_RS07515	COG4193	domain, Protein
SPNINV200_RS07525	COG3935	DnaD domain protein
SPNINV200_RS07540	COG2226	methyltransferase
SPNINV200_RS07550	COG3842	ATPase activity
SPNINV200_RS07560	COG1335	isochorismatase
SPNINV200_RS07565	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SPNINV200_RS07570	COG0513	Belongs to the DEAD box helicase family
SPNINV200_RS07575	COG2223	nitrite transmembrane transporter activity
SPNINV200_RS07580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPNINV200_RS07585	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPNINV200_RS07590	COG3442	glutamine amidotransferase
SPNINV200_RS07595	COG0006	proline dipeptidase activity
SPNINV200_RS07600	COG2801	Transposase and inactivated derivatives
SPNINV200_RS07615	COG4720	Psort location CytoplasmicMembrane, score
SPNINV200_RS07620	COG0351	phosphomethylpyrimidine kinase
SPNINV200_RS07645	COG2824	Alkylphosphonate utilization operon protein PhnA
SPNINV200_RS07650	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SPNINV200_RS07670	COG0463	Glycosyl transferase, family 2
SPNINV200_RS07675	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPNINV200_RS07680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPNINV200_RS07685	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SPNINV200_RS07690	COG2384	SAM-dependent methyltransferase
SPNINV200_RS07710	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPNINV200_RS07715	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SPNINV200_RS07720	COG0204	Acyl-transferase
SPNINV200_RS07735	COG2910	NAD(P)H-binding
SPNINV200_RS07750	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SPNINV200_RS07755	COG5002	protein histidine kinase activity
SPNINV200_RS07760	COG0745	RESPONSE REGULATOR receiver
SPNINV200_RS07775	COG1959	2 iron, 2 sulfur cluster binding
SPNINV200_RS07840	COG3590	peptidase
SPNINV200_RS07855	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPNINV200_RS07860	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SPNINV200_RS07870	COG1136	(ABC) transporter
SPNINV200_RS07870	COG0577	efflux transmembrane transporter activity
SPNINV200_RS07915	COG3599	regulation of cell shape
SPNINV200_RS07935	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPNINV200_RS07955	COG1051	belongs to the nudix hydrolase family
SPNINV200_RS07960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPNINV200_RS07975	COG0768	penicillin binding
SPNINV200_RS07990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPNINV200_RS08010	COG2731	YhcH YjgK YiaL family protein
SPNINV200_RS08015	COG0395	ABC-type sugar transport system, permease component
SPNINV200_RS08020	COG1175	transmembrane transport
SPNINV200_RS08030	COG1263	PTS System
SPNINV200_RS08030	COG2190	(PTS) system
SPNINV200_RS08030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPNINV200_RS08040	COG0673	inositol 2-dehydrogenase activity
SPNINV200_RS08045	COG4409	exo-alpha-(2->6)-sialidase activity
SPNINV200_RS08055	COG1175	transmembrane transport
SPNINV200_RS08060	COG1653	transport
SPNINV200_RS08085	COG3458	cephalosporin-C deacetylase activity
SPNINV200_RS08095	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPNINV200_RS08110	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPNINV200_RS08115	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPNINV200_RS08120	COG0653	protein targeting
SPNINV200_RS08130	COG1131	(ABC) transporter
SPNINV200_RS08160	COG0778	Nitroreductase
SPNINV200_RS08165	COG1484	DNA-dependent DNA replication
SPNINV200_RS08180	COG1725	Transcriptional regulator
SPNINV200_RS08185	COG1131	(ABC) transporter
SPNINV200_RS08195	COG1668	transmembrane transport
SPNINV200_RS08200	COG4152	abc transporter atp-binding protein
SPNINV200_RS08220	COG1940	carbohydrate kinase activity
SPNINV200_RS08225	COG1263	PTS System
SPNINV200_RS08225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPNINV200_RS08225	COG2190	(PTS) system
SPNINV200_RS08235	COG1621	beta-fructofuranosidase activity
SPNINV200_RS08240	COG1609	Transcriptional regulator
SPNINV200_RS08250	COG3425	synthase
SPNINV200_RS08280	COG2815	serine threonine protein kinase
SPNINV200_RS08280	COG0515	serine threonine protein kinase
SPNINV200_RS08285	COG0631	protein serine/threonine phosphatase activity
SPNINV200_RS08290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPNINV200_RS08290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPNINV200_RS08300	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPNINV200_RS08310	COG0194	GDP metabolic process
SPNINV200_RS08320	COG4115	mRNA cleavage
SPNINV200_RS08335	COG2226	methyltransferase
SPNINV200_RS08340	COG0799	negative regulation of ribosome biogenesis
SPNINV200_RS08350	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPNINV200_RS08355	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SPNINV200_RS08360	COG1534	Rna-binding protein
SPNINV200_RS08365	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPNINV200_RS08380	COG0668	transmembrane transport
SPNINV200_RS08405	COG0438	transferase activity, transferring glycosyl groups
SPNINV200_RS08410	COG0438	transferase activity, transferring glycosyl groups
SPNINV200_RS08415	COG0653	protein targeting
SPNINV200_RS08450	COG1442	glycosyl transferase family 8
SPNINV200_RS08480	COG3118	belongs to the thioredoxin family
SPNINV200_RS08485	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SPNINV200_RS08495	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPNINV200_RS08510	COG1164	Oligoendopeptidase f
SPNINV200_RS08515	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPNINV200_RS08575	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPNINV200_RS08585	COG1621	beta-fructofuranosidase activity
SPNINV200_RS08590	COG1653	transport
SPNINV200_RS08595	COG0395	ABC-type sugar transport system, permease component
SPNINV200_RS08600	COG4209	transmembrane transport
SPNINV200_RS08610	COG3711	transcriptional antiterminator
SPNINV200_RS08635	COG3237	CsbD-like
SPNINV200_RS08655	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPNINV200_RS08665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPNINV200_RS08670	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPNINV200_RS08675	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPNINV200_RS08685	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPNINV200_RS08690	COG1940	carbohydrate kinase activity
SPNINV200_RS08690	COG1846	Transcriptional regulator
SPNINV200_RS08740	COG0512	Glutamine amidotransferase of anthranilate synthase
SPNINV200_RS08745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPNINV200_RS08770	COG1285	pathogenesis
SPNINV200_RS08775	COG1178	ABC-type Fe3 transport system permease component
SPNINV200_RS08800	COG5434	Belongs to the glycosyl hydrolase 28 family
SPNINV200_RS08815	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SPNINV200_RS08820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPNINV200_RS08825	COG1132	(ABC) transporter
SPNINV200_RS08830	COG1132	(ABC) transporter
SPNINV200_RS08850	COG0708	Exodeoxyribonuclease III
SPNINV200_RS08865	COG2233	PERMEase
SPNINV200_RS08890	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPNINV200_RS08895	COG1609	Transcriptional regulator
SPNINV200_RS08900	COG1063	alcohol dehydrogenase
SPNINV200_RS08905	COG0789	Transcriptional regulator
SPNINV200_RS08910	COG1230	cation diffusion facilitator family transporter
SPNINV200_RS08920	COG3201	nicotinamide mononucleotide transporter
SPNINV200_RS08925	COG1174	glycine betaine transport
SPNINV200_RS08950	COG1363	Peptidase, m42
SPNINV200_RS08965	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPNINV200_RS08970	COG4605	iron ion homeostasis
SPNINV200_RS08975	COG4604	ABC transporter, ATP-binding protein
SPNINV200_RS08980	COG4607	ABC-type enterochelin transport system periplasmic component
SPNINV200_RS08990	COG1187	pseudouridine synthase activity
SPNINV200_RS09010	COG0517	IMP dehydrogenase activity
SPNINV200_RS09020	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SPNINV200_RS09035	COG0366	Alpha amylase catalytic
SPNINV200_RS09040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPNINV200_RS09040	COG1263	PTS System
SPNINV200_RS09045	COG2188	Transcriptional regulator
SPNINV200_RS09065	COG4608	Belongs to the ABC transporter superfamily
SPNINV200_RS09070	COG0444	Belongs to the ABC transporter superfamily
SPNINV200_RS09075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPNINV200_RS09080	COG0601	transmembrane transport
SPNINV200_RS09085	COG4166	transmembrane transport
SPNINV200_RS09095	COG0366	Alpha amylase catalytic
SPNINV200_RS09105	COG0395	ABC-type sugar transport system, permease component
SPNINV200_RS09110	COG1175	transmembrane transport
SPNINV200_RS09115	COG1653	transport
SPNINV200_RS09120	COG3345	alpha-galactosidase
SPNINV200_RS09125	COG2207	Transcriptional regulator
SPNINV200_RS09130	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPNINV200_RS09130	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPNINV200_RS09245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPNINV200_RS09250	COG2137	regulation of response to DNA damage stimulus
SPNINV200_RS09290	COG4221	oxidoreductase activity
SPNINV200_RS09295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPNINV200_RS09300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPNINV200_RS09340	COG1132	(ABC) transporter
SPNINV200_RS09430	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPNINV200_RS09430	COG5263	repeat protein
SPNINV200_RS09450	COG1316	TRANSCRIPTIONal
SPNINV200_RS09460	COG0802	atpase or kinase
SPNINV200_RS09485	COG1136	(ABC) transporter
SPNINV200_RS09515	COG1253	flavin adenine dinucleotide binding
SPNINV200_RS09530	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPNINV200_RS09540	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPNINV200_RS09550	COG0742	ribosomal rna small subunit methyltransferase
SPNINV200_RS09570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPNINV200_RS09575	COG1254	Belongs to the acylphosphatase family
SPNINV200_RS09585	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPNINV200_RS09595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPNINV200_RS09610	COG1564	THIamine pyrophosphokinase
SPNINV200_RS09620	COG1162	GTPase activity
SPNINV200_RS09655	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SPNINV200_RS09660	COG0084	hydrolase, TatD family'
SPNINV200_RS09675	COG0436	Aminotransferase
SPNINV200_RS09685	COG0589	response to stress
SPNINV200_RS09690	COG0561	phosphatase activity
SPNINV200_RS09695	COG0252	asparaginase activity
SPNINV200_RS09705	COG1609	Transcriptional regulator
SPNINV200_RS09710	COG2197	response regulator
SPNINV200_RS09715	COG4585	Histidine kinase
SPNINV200_RS09720	COG0842	Transport permease protein
SPNINV200_RS09725	COG1131	(ABC) transporter
SPNINV200_RS09825	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPNINV200_RS09835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPNINV200_RS09870	COG0157	Belongs to the NadC ModD family
SPNINV200_RS09880	COG4133	protoheme IX ABC transporter activity
SPNINV200_RS09885	COG2188	Transcriptional regulator
SPNINV200_RS09890	COG2723	6-phospho-beta-galactosidase activity
SPNINV200_RS09895	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPNINV200_RS09905	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPNINV200_RS09910	COG1454	alcohol dehydrogenase
SPNINV200_RS09910	COG1012	belongs to the aldehyde dehydrogenase family
SPNINV200_RS09920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPNINV200_RS09930	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPNINV200_RS09940	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SPNINV200_RS09960	COG3623	hexulose-6-phosphate isomerase
SPNINV200_RS09970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPNINV200_RS09980	COG3037	sugar-specific permease SgaT UlaA
SPNINV200_RS09990	COG1847	R3H domain protein
SPNINV200_RS09995	COG0706	membrane insertase activity
SPNINV200_RS10005	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SPNINV200_RS10045	COG4537	Required for transformation and DNA binding
SPNINV200_RS10050	COG1459	type II secretion system
SPNINV200_RS10055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPNINV200_RS10065	COG1063	alcohol dehydrogenase
SPNINV200_RS10095	COG3759	membrane
SPNINV200_RS10115	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SPNINV200_RS10115	COG0131	Imidazoleglycerol-phosphate dehydratase
SPNINV200_RS10120	COG0534	Mate efflux family protein
SPNINV200_RS10235	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPNINV200_RS10240	COG1132	(ABC) transporter
SPNINV200_RS10250	COG1132	(ABC) transporter
SPNINV200_RS10260	COG1438	arginine binding
SPNINV200_RS10280	COG0745	RESPONSE REGULATOR receiver
SPNINV200_RS10285	COG5002	protein histidine kinase activity
SPNINV200_RS10290	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPNINV200_RS10295	COG0573	inorganic phosphate transmembrane transporter activity
SPNINV200_RS10305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPNINV200_RS10310	COG0704	Plays a role in the regulation of phosphate uptake
SPNINV200_RS10330	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPNINV200_RS10340	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPNINV200_RS10355	COG0697	spore germination
SPNINV200_RS10360	COG4499	WXG100 protein secretion system (Wss), protein YukC
SPNINV200_RS10360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPNINV200_RS10370	COG2217	Heavy metal translocating P-type atpase
SPNINV200_RS10380	COG2226	methyltransferase
SPNINV200_RS10400	COG0058	SHG alpha-glucan phosphorylase activity
SPNINV200_RS10405	COG1640	4-alpha-glucanotransferase
SPNINV200_RS10410	COG2182	Extracellular solute-binding protein
SPNINV200_RS10415	COG1175	transmembrane transport
SPNINV200_RS10420	COG3833	ABC-type maltose transport systems, permease component
SPNINV200_RS10425	COG5521	maltodextrose utilization protein MalA
SPNINV200_RS10430	COG1609	Transcriptional regulator
SPNINV200_RS10440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPNINV200_RS10475	COG1476	TRANSCRIPTIONal
SPNINV200_RS10505	COG2151	metal-sulfur cluster biosynthetic enzyme
SPNINV200_RS10520	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPNINV200_RS10525	COG3959	Transketolase, thiamine diphosphate binding domain
SPNINV200_RS10540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPNINV200_RS10560	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPNINV200_RS10600	COG0383	alpha-mannosidase activity
SPNINV200_RS10610	COG3537	Alpha-1,2-mannosidase
SPNINV200_RS10630	COG0549	Belongs to the carbamate kinase family
SPNINV200_RS10635	COG1288	antiporter activity
SPNINV200_RS10640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPNINV200_RS10650	COG3064	Membrane
SPNINV200_RS10650	COG3583	domain protein
SPNINV200_RS10650	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPNINV200_RS10660	COG1454	alcohol dehydrogenase
SPNINV200_RS10680	COG3716	PTS system mannose fructose sorbose family IID component
SPNINV200_RS10690	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPNINV200_RS10710	COG1070	Carbohydrate kinase
SPNINV200_RS10720	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPNINV200_RS10720	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPNINV200_RS10725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPNINV200_RS10730	COG1121	(ABC) transporter
SPNINV200_RS10735	COG1846	Transcriptional regulator
SPNINV200_RS10740	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPNINV200_RS10750	COG1696	Membrane protein involved in D-alanine export
SPNINV200_RS10765	COG2211	Major facilitator Superfamily
SPNINV200_RS10775	COG3344	reverse transcriptase
SPNINV200_RS10790	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPNINV200_RS10795	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SPNINV200_RS10815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPNINV200_RS10825	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPNINV200_RS10830	COG5002	protein histidine kinase activity
SPNINV200_RS10835	COG0745	RESPONSE REGULATOR receiver
SPNINV200_RS10850	COG0542	response to heat
SPNINV200_RS10855	COG4463	regulation of RNA biosynthetic process
SPNINV200_RS10860	COG1116	anion transmembrane transporter activity
SPNINV200_RS10865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SPNINV200_RS10870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SPNINV200_RS10890	COG0305	Participates in initiation and elongation during chromosome replication
SPNINV200_RS10910	COG1040	competence protein
SPNINV200_RS10915	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPNINV200_RS10920	COG1739	Uncharacterized protein family UPF0029
SPNINV200_RS10950	COG0052	Belongs to the universal ribosomal protein uS2 family
SPNINV200_RS10955	COG3942	CHAP domain
SPNINV200_RS10965	COG1792	Involved in formation and maintenance of cell shape
SPNINV200_RS10970	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPNINV200_RS10975	COG1122	ATPase activity
SPNINV200_RS10980	COG1122	ATPase activity
SPNINV200_RS10985	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPNINV200_RS10995	COG0612	Peptidase, M16
SPNINV200_RS11000	COG0612	Peptidase, M16
SPNINV200_RS11005	COG2501	S4 domain
SPNINV200_RS11015	COG0516	GMP reductase activity
SPNINV200_RS11015	COG0517	IMP dehydrogenase activity
SPNINV200_RS11020	COG0180	Tryptophanyl-tRNA synthetase
SPNINV200_RS11025	COG0488	(ABC) transporter
SPNINV200_RS11035	COG1511	domain protein
SPNINV200_RS11045	COG1511	domain protein
SPNINV200_RS11090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPNINV200_RS11095	COG1475	DNA binding
SPNINV200_RS11145	COG0577	efflux transmembrane transporter activity
SPNINV200_RS11145	COG1136	(ABC) transporter