locus-tag	class	description
MDRSPN_RS00010	COG0592	DNA-directed DNA polymerase activity
MDRSPN_RS00020	COG0012	GTP binding
MDRSPN_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MDRSPN_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MDRSPN_RS00055	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MDRSPN_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MDRSPN_RS00130	COG0756	dUTP diphosphatase activity
MDRSPN_RS00140	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MDRSPN_RS00155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MDRSPN_RS00180	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MDRSPN_RS00180	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MDRSPN_RS00185	COG1832	CoA-binding protein
MDRSPN_RS00190	COG2855	membrane
MDRSPN_RS00195	COG0436	Aminotransferase
MDRSPN_RS00200	COG1381	Involved in DNA repair and RecF pathway recombination
MDRSPN_RS00210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MDRSPN_RS00225	COG2274	protein secretion by the type I secretion system
MDRSPN_RS00230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MDRSPN_RS00245	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MDRSPN_RS00250	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MDRSPN_RS00260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MDRSPN_RS00275	COG0151	Belongs to the GarS family
MDRSPN_RS00290	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MDRSPN_RS00305	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MDRSPN_RS00310	COG3583	domain protein
MDRSPN_RS00310	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MDRSPN_RS00310	COG3064	Membrane
MDRSPN_RS00325	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MDRSPN_RS00330	COG3715	PTS system
MDRSPN_RS00335	COG3716	PTS system mannose fructose sorbose family IID component
MDRSPN_RS00345	COG2222	sugar isomerase
MDRSPN_RS00355	COG2514	catechol 2,3-dioxygenase activity
MDRSPN_RS00360	COG1937	Protein conserved in bacteria
MDRSPN_RS00390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MDRSPN_RS00395	COG0569	domain protein
MDRSPN_RS00405	COG1215	transferase activity, transferring glycosyl groups
MDRSPN_RS00425	COG5002	protein histidine kinase activity
MDRSPN_RS00450	COG4209	transmembrane transport
MDRSPN_RS00455	COG0395	ABC-type sugar transport system, permease component
MDRSPN_RS00465	COG1653	transport
MDRSPN_RS00505	COG1136	(ABC) transporter
MDRSPN_RS00505	COG0577	efflux transmembrane transporter activity
MDRSPN_RS00525	COG1695	Transcriptional regulator
MDRSPN_RS00550	COG0546	phosphoglycolate phosphatase activity
MDRSPN_RS00555	COG1760	l-serine dehydratase
MDRSPN_RS00560	COG1760	l-serine dehydratase
MDRSPN_RS00565	COG1388	LysM domain
MDRSPN_RS00565	COG1705	Flagellar rod assembly protein muramidase FlgJ
MDRSPN_RS00590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MDRSPN_RS00595	COG0137	argininosuccinate synthase activity
MDRSPN_RS00700	COG0494	nUDIX hydrolase
MDRSPN_RS00705	COG0445	tRNA wobble uridine modification
MDRSPN_RS00725	COG1214	PFAM Peptidase M22, glycoprotease
MDRSPN_RS00735	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MDRSPN_RS00750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MDRSPN_RS00755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MDRSPN_RS00760	COG1464	Belongs to the NlpA lipoprotein family
MDRSPN_RS00765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MDRSPN_RS00770	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MDRSPN_RS00790	COG2972	Histidine kinase
MDRSPN_RS00795	COG2207	Transcriptional regulator
MDRSPN_RS00795	COG4753	response regulator
MDRSPN_RS00805	COG1780	Probably involved in ribonucleotide reductase function
MDRSPN_RS00835	COG2818	Glycosylase
MDRSPN_RS00865	COG0582	viral genome integration into host DNA
MDRSPN_RS00945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MDRSPN_RS00950	COG0006	proline dipeptidase activity
MDRSPN_RS00960	COG1393	Belongs to the ArsC family
MDRSPN_RS00985	COG0285	dihydrofolate synthase activity
MDRSPN_RS00995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MDRSPN_RS01060	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MDRSPN_RS01085	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MDRSPN_RS01125	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MDRSPN_RS01140	COG0201	protein transport
MDRSPN_RS01150	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MDRSPN_RS01155	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MDRSPN_RS01165	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MDRSPN_RS01170	COG0202	RNA polymerase activity
MDRSPN_RS01180	COG3830	Belongs to the UPF0237 family
MDRSPN_RS01185	COG2848	UPF0210 protein
MDRSPN_RS01205	COG3842	ATPase activity
MDRSPN_RS01220	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MDRSPN_RS01225	COG1349	DNA-binding transcription factor activity
MDRSPN_RS01235	COG1447	Phosphotransferase system cellobiose-specific component IIA
MDRSPN_RS01240	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MDRSPN_RS01245	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MDRSPN_RS01250	COG1882	Formate acetyltransferase
MDRSPN_RS01300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MDRSPN_RS01305	COG4589	Belongs to the CDS family
MDRSPN_RS01310	COG0750	zinc metalloprotease
MDRSPN_RS01320	COG2723	6-phospho-beta-galactosidase activity
MDRSPN_RS01325	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MDRSPN_RS01335	COG1523	belongs to the glycosyl hydrolase 13 family
MDRSPN_RS01360	COG2176	DNA-directed DNA polymerase activity
MDRSPN_RS01380	COG2309	aminopeptidase activity
MDRSPN_RS01385	COG2261	transglycosylase associated protein
MDRSPN_RS01390	COG1187	pseudouridine synthase activity
MDRSPN_RS01400	COG3579	cysteine-type endopeptidase activity
MDRSPN_RS01405	COG3716	PTS system mannose fructose sorbose family IID component
MDRSPN_RS01410	COG3715	PTS system
MDRSPN_RS01420	COG1064	alcohol dehydrogenase
MDRSPN_RS01425	COG0561	phosphatase activity
MDRSPN_RS01430	COG2252	PERMEase
MDRSPN_RS01440	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MDRSPN_RS01445	COG0285	dihydrofolate synthase activity
MDRSPN_RS01450	COG0302	gtp cyclohydrolase
MDRSPN_RS01455	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MDRSPN_RS01455	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MDRSPN_RS01465	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MDRSPN_RS01485	COG2723	6-phospho-beta-galactosidase activity
MDRSPN_RS01500	COG3711	transcriptional antiterminator
MDRSPN_RS01500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MDRSPN_RS01515	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MDRSPN_RS01535	COG0386	Belongs to the glutathione peroxidase family
MDRSPN_RS01540	COG5492	domain, Protein
MDRSPN_RS01570	COG1028	Short-chain dehydrogenase reductase Sdr
MDRSPN_RS01580	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
MDRSPN_RS01585	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MDRSPN_RS01590	COG3715	PTS system
MDRSPN_RS01595	COG3716	PTS system mannose fructose sorbose family IID component
MDRSPN_RS01610	COG1609	Transcriptional regulator
MDRSPN_RS01640	COG4839	cell division protein FtsL
MDRSPN_RS01645	COG0768	penicillin binding
MDRSPN_RS01670	COG0366	Alpha amylase catalytic
MDRSPN_RS01675	COG4166	transmembrane transport
MDRSPN_RS01715	COG3475	LICD family
MDRSPN_RS01735	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MDRSPN_RS01740	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MDRSPN_RS01750	COG1088	dTDP-glucose 4,6-dehydratase activity
MDRSPN_RS01755	COG1091	dTDP-4-dehydrorhamnose reductase activity
MDRSPN_RS01765	COG4166	transmembrane transport
MDRSPN_RS01775	COG0366	Alpha amylase catalytic
MDRSPN_RS01780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MDRSPN_RS01805	COG0116	Belongs to the methyltransferase superfamily
MDRSPN_RS01815	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MDRSPN_RS01820	COG0745	RESPONSE REGULATOR receiver
MDRSPN_RS01875	COG1304	FMN binding
MDRSPN_RS01885	COG4585	Histidine kinase
MDRSPN_RS01890	COG2197	response regulator
MDRSPN_RS01915	COG0582	viral genome integration into host DNA
MDRSPN_RS01925	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MDRSPN_RS01930	COG0681	Belongs to the peptidase S26 family
MDRSPN_RS01955	COG1115	amino acid carrier protein
MDRSPN_RS01980	COG0527	aspartate kinase activity
MDRSPN_RS01990	COG1024	Enoyl-CoA hydratase
MDRSPN_RS01995	COG1846	Transcriptional regulator
MDRSPN_RS02005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MDRSPN_RS02015	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MDRSPN_RS02020	COG1028	Short-chain dehydrogenase reductase Sdr
MDRSPN_RS02025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MDRSPN_RS02040	COG0439	Biotin carboxylase
MDRSPN_RS02045	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MDRSPN_RS02090	COG1063	alcohol dehydrogenase
MDRSPN_RS02125	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MDRSPN_RS02135	COG1461	Dihydroxyacetone kinase
MDRSPN_RS02140	COG0028	Belongs to the TPP enzyme family
MDRSPN_RS02145	COG0440	acetolactate synthase activity
MDRSPN_RS02165	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MDRSPN_RS02185	COG0765	amino acid transport
MDRSPN_RS02205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MDRSPN_RS02215	COG1882	Formate acetyltransferase
MDRSPN_RS02220	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MDRSPN_RS02225	COG0569	domain protein
MDRSPN_RS02240	COG1122	ATPase activity
MDRSPN_RS02255	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MDRSPN_RS02260	COG0671	phosphoesterase, PA-phosphatase related
MDRSPN_RS02270	COG1247	-acetyltransferase
MDRSPN_RS02280	COG0504	CTP synthase activity
MDRSPN_RS02285	COG1283	sodium-dependent phosphate transmembrane transporter activity
MDRSPN_RS02305	COG0789	Transcriptional regulator
MDRSPN_RS02310	COG0174	glutamine synthetase
MDRSPN_RS02325	COG0732	type I restriction modification DNA specificity domain
MDRSPN_RS02335	COG4974	Belongs to the 'phage' integrase family
MDRSPN_RS02340	COG0732	type I restriction modification DNA specificity domain
MDRSPN_RS02385	COG0484	heat shock protein binding
MDRSPN_RS02395	COG0537	adenosine 5'-monophosphoramidase activity
MDRSPN_RS02400	COG1131	(ABC) transporter
MDRSPN_RS02405	COG4473	ABC transporter
MDRSPN_RS02425	COG3290	protein histidine kinase activity
MDRSPN_RS02445	COG0194	GDP metabolic process
MDRSPN_RS02455	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MDRSPN_RS02465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MDRSPN_RS02465	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MDRSPN_RS02470	COG0631	protein serine/threonine phosphatase activity
MDRSPN_RS02475	COG0515	serine threonine protein kinase
MDRSPN_RS02475	COG2815	serine threonine protein kinase
MDRSPN_RS02495	COG3425	synthase
MDRSPN_RS02510	COG1609	Transcriptional regulator
MDRSPN_RS02515	COG1621	beta-fructofuranosidase activity
MDRSPN_RS02530	COG1263	PTS System
MDRSPN_RS02530	COG2190	(PTS) system
MDRSPN_RS02530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MDRSPN_RS02535	COG1940	carbohydrate kinase activity
MDRSPN_RS02555	COG4152	abc transporter atp-binding protein
MDRSPN_RS02560	COG1668	transmembrane transport
MDRSPN_RS02570	COG1131	(ABC) transporter
MDRSPN_RS02575	COG1725	Transcriptional regulator
MDRSPN_RS02590	COG1484	DNA-dependent DNA replication
MDRSPN_RS02595	COG0778	Nitroreductase
MDRSPN_RS02625	COG1131	(ABC) transporter
MDRSPN_RS02640	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MDRSPN_RS02645	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MDRSPN_RS02660	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MDRSPN_RS02690	COG1653	transport
MDRSPN_RS02695	COG1175	transmembrane transport
MDRSPN_RS02705	COG4409	exo-alpha-(2->6)-sialidase activity
MDRSPN_RS02710	COG0673	inositol 2-dehydrogenase activity
MDRSPN_RS02720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MDRSPN_RS02720	COG1263	PTS System
MDRSPN_RS02720	COG2190	(PTS) system
MDRSPN_RS02730	COG1175	transmembrane transport
MDRSPN_RS02735	COG0395	ABC-type sugar transport system, permease component
MDRSPN_RS02740	COG2731	YhcH YjgK YiaL family protein
MDRSPN_RS02760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MDRSPN_RS02775	COG0768	penicillin binding
MDRSPN_RS02790	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MDRSPN_RS02795	COG1051	belongs to the nudix hydrolase family
MDRSPN_RS02815	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MDRSPN_RS02835	COG3599	regulation of cell shape
MDRSPN_RS02875	COG0577	efflux transmembrane transporter activity
MDRSPN_RS02875	COG1136	(ABC) transporter
MDRSPN_RS02885	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MDRSPN_RS02890	COG0803	Belongs to the bacterial solute-binding protein 9 family
MDRSPN_RS02905	COG3590	peptidase
MDRSPN_RS02940	COG0765	amino acid transport
MDRSPN_RS02950	COG1304	FMN binding
MDRSPN_RS02955	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MDRSPN_RS02970	COG1304	FMN binding
MDRSPN_RS02990	COG0352	thiamine-phosphate diphosphorylase activity
MDRSPN_RS03005	COG4172	Belongs to the ABC transporter superfamily
MDRSPN_RS03015	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MDRSPN_RS03030	COG0352	thiamine-phosphate diphosphorylase activity
MDRSPN_RS03050	COG2217	Heavy metal translocating P-type atpase
MDRSPN_RS03055	COG0028	Belongs to the TPP enzyme family
MDRSPN_RS03070	COG2723	6-phospho-beta-galactosidase activity
MDRSPN_RS03075	COG1482	cell wall glycoprotein biosynthetic process
MDRSPN_RS03080	COG0733	neurotransmitter:sodium symporter activity
MDRSPN_RS03095	COG2081	HI0933 family
MDRSPN_RS03100	COG1307	EDD domain protein, DegV family
MDRSPN_RS03110	COG2131	deaminase
MDRSPN_RS03115	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MDRSPN_RS03160	COG0617	tRNA 3'-terminal CCA addition
MDRSPN_RS03160	COG0517	IMP dehydrogenase activity
MDRSPN_RS03160	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MDRSPN_RS03170	COG2884	Cell division ATP-binding protein ftsE
MDRSPN_RS03175	COG2177	Part of the ABC transporter FtsEX involved in
MDRSPN_RS03180	COG1263	PTS System
MDRSPN_RS03180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MDRSPN_RS03180	COG2190	(PTS) system
MDRSPN_RS03190	COG0513	Belongs to the DEAD box helicase family
MDRSPN_RS03210	COG0167	dihydroorotate dehydrogenase activity
MDRSPN_RS03220	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MDRSPN_RS03225	COG4470	Protein conserved in bacteria
MDRSPN_RS03240	COG0488	(ABC) transporter
MDRSPN_RS03270	COG1837	Belongs to the UPF0109 family
MDRSPN_RS03285	COG0513	Belongs to the DEAD box helicase family
MDRSPN_RS03300	COG0726	polysaccharide deacetylase
MDRSPN_RS03305	COG0656	L-ascorbic acid biosynthetic process
MDRSPN_RS03330	COG0431	NADPH-dependent FMN reductase
MDRSPN_RS03330	COG3976	FMN-binding domain protein
MDRSPN_RS03330	COG1053	succinate dehydrogenase
MDRSPN_RS03360	COG1272	protein, Hemolysin III
MDRSPN_RS03375	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MDRSPN_RS03380	COG1393	Belongs to the ArsC family
MDRSPN_RS03390	COG1126	abc transporter atp-binding protein
MDRSPN_RS03400	COG0492	ferredoxin-NADP+ reductase activity
MDRSPN_RS03420	COG0561	phosphatase activity
MDRSPN_RS03435	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MDRSPN_RS03440	COG0697	spore germination
MDRSPN_RS03445	COG2188	Transcriptional regulator
MDRSPN_RS03465	COG1132	(ABC) transporter
MDRSPN_RS03470	COG1132	(ABC) transporter
MDRSPN_RS03485	COG1129	ABC transporter
MDRSPN_RS03515	COG0826	peptidase U32
MDRSPN_RS03530	COG1131	(ABC) transporter
MDRSPN_RS03550	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MDRSPN_RS03560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MDRSPN_RS03585	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MDRSPN_RS03600	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MDRSPN_RS03620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MDRSPN_RS03630	COG0647	UMP catabolic process
MDRSPN_RS03640	COG1393	Belongs to the ArsC family
MDRSPN_RS03650	COG0483	inositol monophosphate 1-phosphatase activity
MDRSPN_RS03655	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
MDRSPN_RS03655	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MDRSPN_RS03660	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MDRSPN_RS03665	COG0573	inorganic phosphate transmembrane transporter activity
MDRSPN_RS03670	COG0581	inorganic phosphate transmembrane transporter activity
MDRSPN_RS03675	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MDRSPN_RS03680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MDRSPN_RS03685	COG0704	Plays a role in the regulation of phosphate uptake
MDRSPN_RS03690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MDRSPN_RS03695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MDRSPN_RS03700	COG3527	Alpha-acetolactate decarboxylase
MDRSPN_RS03715	COG3842	ATPase activity
MDRSPN_RS03755	COG4555	ABC transporter
MDRSPN_RS03770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MDRSPN_RS03795	COG0287	Prephenate dehydrogenase
MDRSPN_RS03800	COG3679	Belongs to the UPF0342 family
MDRSPN_RS03810	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MDRSPN_RS03815	COG0077	Prephenate dehydratase
MDRSPN_RS03825	COG3475	LICD family
MDRSPN_RS03835	COG1215	transferase activity, transferring glycosyl groups
MDRSPN_RS03875	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MDRSPN_RS03875	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MDRSPN_RS03880	COG1132	(ABC) transporter
MDRSPN_RS03890	COG0402	S-adenosylhomocysteine deaminase activity
MDRSPN_RS03915	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MDRSPN_RS03935	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MDRSPN_RS03940	COG0716	FMN binding
MDRSPN_RS03945	COG1605	Chorismate mutase
MDRSPN_RS03945	COG0077	Prephenate dehydratase
MDRSPN_RS03950	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MDRSPN_RS03955	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MDRSPN_RS03980	COG1078	dGTPase activity
MDRSPN_RS03995	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MDRSPN_RS04010	COG1704	LemA family
MDRSPN_RS04020	COG0488	(ABC) transporter
MDRSPN_RS04035	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MDRSPN_RS04050	COG0505	Belongs to the CarA family
MDRSPN_RS04060	COG3475	LICD family
MDRSPN_RS04065	COG3475	LICD family
MDRSPN_RS04080	COG1063	alcohol dehydrogenase
MDRSPN_RS04095	COG4750	Nucleotidyl transferase
MDRSPN_RS04100	COG0758	DNA mediated transformation
MDRSPN_RS04110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MDRSPN_RS04115	COG2832	Protein of unknown function (DUF454)
MDRSPN_RS04120	COG3142	Participates in the control of copper homeostasis
MDRSPN_RS04140	COG0473	3-isopropylmalate dehydrogenase activity
MDRSPN_RS04150	COG0066	3-isopropylmalate dehydratase activity
MDRSPN_RS04160	COG1401	restriction endodeoxyribonuclease activity
MDRSPN_RS04185	COG1196	nuclear chromosome segregation
MDRSPN_RS04190	COG0561	phosphatase activity
MDRSPN_RS04195	COG0561	phosphatase activity
MDRSPN_RS04200	COG0552	protein localization to endoplasmic reticulum
MDRSPN_RS04205	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MDRSPN_RS04210	COG1126	abc transporter atp-binding protein
MDRSPN_RS04215	COG0765	amino acid transport
MDRSPN_RS04245	COG1827	regulation of RNA biosynthetic process
MDRSPN_RS04255	COG4684	Psort location CytoplasmicMembrane, score
MDRSPN_RS04260	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MDRSPN_RS04280	COG1194	a g-specific adenine glycosylase
MDRSPN_RS04285	COG0745	RESPONSE REGULATOR receiver
MDRSPN_RS04290	COG5002	protein histidine kinase activity
MDRSPN_RS04295	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MDRSPN_RS04310	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MDRSPN_RS04325	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MDRSPN_RS04330	COG3764	Sortase (surface protein transpeptidase)
MDRSPN_RS04350	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MDRSPN_RS04385	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MDRSPN_RS04390	COG1438	arginine binding
MDRSPN_RS04395	COG0497	DNA recombination
MDRSPN_RS04400	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MDRSPN_RS04445	COG3684	Belongs to the aldolase LacD family
MDRSPN_RS04450	COG3711	transcriptional antiterminator
MDRSPN_RS04465	COG2723	6-phospho-beta-galactosidase activity
MDRSPN_RS04480	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MDRSPN_RS04485	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MDRSPN_RS04490	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MDRSPN_RS04495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MDRSPN_RS04560	COG0681	Belongs to the peptidase S26 family
MDRSPN_RS04570	COG4509	Sortase family
MDRSPN_RS04585	COG1970	mechanosensitive ion channel activity
MDRSPN_RS04595	COG4708	membrane
MDRSPN_RS04605	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MDRSPN_RS04620	COG1942	4-Oxalocrotonate Tautomerase
MDRSPN_RS04625	COG1435	thymidine kinase activity
MDRSPN_RS04635	COG2890	protein-(glutamine-N5) methyltransferase activity
MDRSPN_RS04660	COG0741	lytic transglycosylase activity
MDRSPN_RS04670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MDRSPN_RS04690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MDRSPN_RS04695	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MDRSPN_RS04765	COG1597	lipid kinase activity
MDRSPN_RS04800	COG0772	Belongs to the SEDS family
MDRSPN_RS04805	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MDRSPN_RS04825	COG0358	DNA primase activity
MDRSPN_RS04830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MDRSPN_RS04835	COG2151	metal-sulfur cluster biosynthetic enzyme
MDRSPN_RS04840	COG0438	transferase activity, transferring glycosyl groups
MDRSPN_RS04845	COG0438	transferase activity, transferring glycosyl groups
MDRSPN_RS04875	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MDRSPN_RS04885	COG4109	DRTGG domain
MDRSPN_RS04890	COG0024	Methionine aminopeptidase
MDRSPN_RS04905	COG0210	DNA helicase
MDRSPN_RS04915	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MDRSPN_RS04935	COG1104	cysteine desulfurase activity
MDRSPN_RS04940	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MDRSPN_RS04950	COG2357	RelA SpoT domain protein
MDRSPN_RS04960	COG0564	pseudouridine synthase activity
MDRSPN_RS04965	COG0280	phosphate acetyltransferase
MDRSPN_RS05005	COG0196	riboflavin kinase activity
MDRSPN_RS05010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MDRSPN_RS05015	COG1307	EDD domain protein, DegV family
MDRSPN_RS05025	COG0488	(ABC) transporter
MDRSPN_RS05045	COG1523	belongs to the glycosyl hydrolase 13 family
MDRSPN_RS05050	COG1012	belongs to the aldehyde dehydrogenase family
MDRSPN_RS05060	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MDRSPN_RS05070	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MDRSPN_RS05080	COG0560	Phosphoserine phosphatase
MDRSPN_RS05100	COG0582	viral genome integration into host DNA
MDRSPN_RS05145	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
MDRSPN_RS05145	COG3583	domain protein
MDRSPN_RS05155	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MDRSPN_RS05175	COG0095	Lipoate-protein ligase
MDRSPN_RS05180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MDRSPN_RS05185	COG0508	dehydrogenase complex catalyzes the overall conversion of
MDRSPN_RS05190	COG0022	dehydrogenase e1 component
MDRSPN_RS05195	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MDRSPN_RS05200	COG0534	Mate efflux family protein
MDRSPN_RS05210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MDRSPN_RS05215	COG1051	belongs to the nudix hydrolase family
MDRSPN_RS05230	COG1011	Hydrolase
MDRSPN_RS05235	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
MDRSPN_RS05245	COG3443	Belongs to the bacterial solute-binding protein 9 family
MDRSPN_RS05245	COG0803	Belongs to the bacterial solute-binding protein 9 family
MDRSPN_RS05250	COG0531	amino acid
MDRSPN_RS05255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MDRSPN_RS05260	COG0785	Cytochrome C biogenesis protein
MDRSPN_RS05280	COG0584	glycerophosphoryl diester phosphodiesterase
MDRSPN_RS05285	COG2176	DNA-directed DNA polymerase activity
MDRSPN_RS05295	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MDRSPN_RS05305	COG0494	nUDIX hydrolase
MDRSPN_RS05325	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MDRSPN_RS05355	COG4122	O-methyltransferase activity
MDRSPN_RS05370	COG0500	methyltransferase
MDRSPN_RS05370	COG3615	Tellurite resistance protein tehB
MDRSPN_RS05380	COG0557	exoribonuclease II activity
MDRSPN_RS05395	COG2814	Major facilitator Superfamily
MDRSPN_RS05400	COG0237	dephospho-CoA kinase activity
MDRSPN_RS05405	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MDRSPN_RS05415	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MDRSPN_RS05425	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MDRSPN_RS05430	COG4193	domain, Protein
MDRSPN_RS05430	COG5263	repeat protein
MDRSPN_RS05435	COG0167	dihydroorotate dehydrogenase activity
MDRSPN_RS05440	COG0543	2 iron, 2 sulfur cluster binding
MDRSPN_RS05470	COG1131	(ABC) transporter
MDRSPN_RS05480	COG2333	competence protein COMEC
MDRSPN_RS05480	COG0658	competence protein
MDRSPN_RS05485	COG1596	polysaccharide export
MDRSPN_RS05485	COG1555	photosystem II stabilization
MDRSPN_RS05490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MDRSPN_RS05495	COG0686	Belongs to the AlaDH PNT family
MDRSPN_RS05500	COG0686	Belongs to the AlaDH PNT family
MDRSPN_RS05505	COG0686	Belongs to the AlaDH PNT family
MDRSPN_RS05525	COG1702	phosphate starvation-inducible protein PhoH
MDRSPN_RS05535	COG2996	Protein conserved in bacteria
MDRSPN_RS05545	COG0528	UMP kinase activity
MDRSPN_RS05565	COG0470	DNA polymerase III
MDRSPN_RS05575	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MDRSPN_RS05590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MDRSPN_RS05595	COG0564	pseudouridine synthase activity
MDRSPN_RS05600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MDRSPN_RS05605	COG0583	DNA-binding transcription factor activity
MDRSPN_RS05625	COG0561	phosphatase activity
MDRSPN_RS05630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MDRSPN_RS05650	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MDRSPN_RS05660	COG1982	Orn Lys Arg decarboxylase major
MDRSPN_RS05675	COG0577	efflux transmembrane transporter activity
MDRSPN_RS05680	COG1136	(ABC) transporter
MDRSPN_RS05700	COG2183	response to ionizing radiation
MDRSPN_RS05710	COG0701	Predicted permease
MDRSPN_RS05715	COG3689	TIGRFAM TIGR03943 family protein
MDRSPN_RS05775	COG0469	pyruvate kinase activity
MDRSPN_RS05795	COG1438	arginine binding
MDRSPN_RS05805	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MDRSPN_RS05865	COG1104	cysteine desulfurase activity
MDRSPN_RS05875	COG0697	spore germination
MDRSPN_RS05875	COG1674	ftsk spoiiie
MDRSPN_RS05880	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MDRSPN_RS05880	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MDRSPN_RS05880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MDRSPN_RS05885	COG1105	Belongs to the carbohydrate kinase PfkB family
MDRSPN_RS05890	COG1349	DNA-binding transcription factor activity
MDRSPN_RS05905	COG0628	permease
MDRSPN_RS05910	COG1686	Belongs to the peptidase S11 family
MDRSPN_RS05915	COG0719	Fe-S assembly protein
MDRSPN_RS05925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MDRSPN_RS05930	COG0719	Fe-S assembly protein
MDRSPN_RS05945	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MDRSPN_RS05950	COG1956	GAF domain-containing protein
MDRSPN_RS05960	COG0539	negative regulation of cytoplasmic translation
MDRSPN_RS05995	COG4166	transmembrane transport
MDRSPN_RS06000	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MDRSPN_RS06005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MDRSPN_RS06010	COG0187	DNA topoisomerase II activity
MDRSPN_RS06025	COG1079	Belongs to the binding-protein-dependent transport system permease family
MDRSPN_RS06030	COG4603	Belongs to the binding-protein-dependent transport system permease family
MDRSPN_RS06035	COG3845	ABC transporter
MDRSPN_RS06040	COG1744	ABC transporter substrate-binding protein PnrA-like
MDRSPN_RS06045	COG0295	cytidine deaminase activity
MDRSPN_RS06055	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MDRSPN_RS06060	COG2813	Specifically methylates the guanine in position
MDRSPN_RS06110	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MDRSPN_RS06130	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MDRSPN_RS06135	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MDRSPN_RS06140	COG1126	abc transporter atp-binding protein
MDRSPN_RS06145	COG0765	amino acid transport
MDRSPN_RS06150	COG4703	Protein of unknown function (DUF1797)
MDRSPN_RS06155	COG0542	response to heat
MDRSPN_RS06165	COG0494	nUDIX hydrolase
MDRSPN_RS06210	COG0187	DNA topoisomerase II activity
MDRSPN_RS06220	COG0693	protein deglycase activity
MDRSPN_RS06225	COG0772	Belongs to the SEDS family
MDRSPN_RS06250	COG5002	protein histidine kinase activity
MDRSPN_RS06255	COG0745	RESPONSE REGULATOR receiver
MDRSPN_RS06280	COG1028	Short-chain dehydrogenase reductase Sdr
MDRSPN_RS06290	COG4989	oxidoreductase activity
MDRSPN_RS06310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MDRSPN_RS06310	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MDRSPN_RS06315	COG0577	efflux transmembrane transporter activity
MDRSPN_RS06320	COG1136	(ABC) transporter
MDRSPN_RS06325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MDRSPN_RS06330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MDRSPN_RS06335	COG1268	BioY protein
MDRSPN_RS06345	COG4443	Transcriptional Coactivator p15 (PC4)
MDRSPN_RS06355	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MDRSPN_RS06355	COG1328	CTP reductase activity
MDRSPN_RS06390	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MDRSPN_RS06430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MDRSPN_RS06440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MDRSPN_RS06445	COG1126	abc transporter atp-binding protein
MDRSPN_RS06460	COG0628	permease
MDRSPN_RS06465	COG2706	6-phosphogluconolactonase activity
MDRSPN_RS06525	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MDRSPN_RS06550	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MDRSPN_RS06555	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MDRSPN_RS06560	COG0626	cystathionine gamma-synthase activity
MDRSPN_RS06565	COG1132	(ABC) transporter
MDRSPN_RS06575	COG4166	transmembrane transport
MDRSPN_RS06585	COG2244	polysaccharide biosynthetic process
MDRSPN_RS06590	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MDRSPN_RS06615	COG2827	Endonuclease containing a URI domain
MDRSPN_RS06620	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MDRSPN_RS06625	COG1098	S1 RNA binding domain
MDRSPN_RS06635	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MDRSPN_RS06640	COG0629	single-stranded DNA binding
MDRSPN_RS06650	COG0017	Asparaginyl-tRNA synthetase
MDRSPN_RS06660	COG0436	Aminotransferase
MDRSPN_RS06685	COG3711	transcriptional antiterminator
MDRSPN_RS06705	COG0242	peptide deformylase activity
MDRSPN_RS06710	COG0625	glutathione transferase activity
MDRSPN_RS06720	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MDRSPN_RS06725	COG0488	(ABC) transporter
MDRSPN_RS06730	COG0617	tRNA 3'-terminal CCA addition
MDRSPN_RS06740	COG1307	EDD domain protein, DegV family
MDRSPN_RS06760	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MDRSPN_RS06780	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MDRSPN_RS06790	COG0251	oxidation-reduction process
MDRSPN_RS06810	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MDRSPN_RS06820	COG5263	repeat protein
MDRSPN_RS06820	COG4193	domain, Protein
MDRSPN_RS06830	COG3935	DnaD domain protein
MDRSPN_RS06845	COG2226	methyltransferase
MDRSPN_RS06850	COG3842	ATPase activity
MDRSPN_RS06860	COG1335	isochorismatase
MDRSPN_RS06875	COG0513	Belongs to the DEAD box helicase family
MDRSPN_RS06880	COG2223	nitrite transmembrane transporter activity
MDRSPN_RS06885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MDRSPN_RS06890	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MDRSPN_RS06895	COG3442	glutamine amidotransferase
MDRSPN_RS06900	COG0006	proline dipeptidase activity
MDRSPN_RS06915	COG4720	Psort location CytoplasmicMembrane, score
MDRSPN_RS06920	COG0351	phosphomethylpyrimidine kinase
MDRSPN_RS06945	COG2824	Alkylphosphonate utilization operon protein PhnA
MDRSPN_RS06965	COG0463	Glycosyl transferase, family 2
MDRSPN_RS06970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MDRSPN_RS06975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MDRSPN_RS06980	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MDRSPN_RS06985	COG2384	SAM-dependent methyltransferase
MDRSPN_RS06995	COG2801	Transposase and inactivated derivatives
MDRSPN_RS07000	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MDRSPN_RS07005	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MDRSPN_RS07010	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
MDRSPN_RS07010	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MDRSPN_RS07010	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MDRSPN_RS07015	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MDRSPN_RS07035	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MDRSPN_RS07040	COG0204	Acyl-transferase
MDRSPN_RS07055	COG2910	NAD(P)H-binding
MDRSPN_RS07085	COG5002	protein histidine kinase activity
MDRSPN_RS07090	COG0745	RESPONSE REGULATOR receiver
MDRSPN_RS07105	COG1959	2 iron, 2 sulfur cluster binding
MDRSPN_RS07155	COG1131	(ABC) transporter
MDRSPN_RS07180	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MDRSPN_RS07190	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MDRSPN_RS07205	COG1136	(ABC) transporter
MDRSPN_RS07225	COG1217	gtp-binding protein TYPA
MDRSPN_RS07230	COG1187	pseudouridine synthase activity
MDRSPN_RS07240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MDRSPN_RS07255	COG0300	oxidoreductase activity
MDRSPN_RS07265	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
MDRSPN_RS07270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MDRSPN_RS07290	COG1940	carbohydrate kinase activity
MDRSPN_RS07305	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MDRSPN_RS07310	COG3064	Membrane
MDRSPN_RS07320	COG2972	Histidine kinase
MDRSPN_RS07325	COG2207	Transcriptional regulator
MDRSPN_RS07325	COG4753	response regulator
MDRSPN_RS07330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MDRSPN_RS07330	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MDRSPN_RS07335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MDRSPN_RS07340	COG0785	Cytochrome C biogenesis protein
MDRSPN_RS07360	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MDRSPN_RS07380	COG3250	beta-galactosidase activity
MDRSPN_RS07385	COG3775	system Galactitol-specific IIC component
MDRSPN_RS07400	COG1404	Belongs to the peptidase S8 family
MDRSPN_RS07425	COG4555	ABC transporter
MDRSPN_RS07465	COG1363	Peptidase, m42
MDRSPN_RS07470	COG1114	Component of the transport system for branched-chain amino acids
MDRSPN_RS07485	COG1573	uracil-dna glycosylase
MDRSPN_RS07500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MDRSPN_RS07540	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MDRSPN_RS07540	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MDRSPN_RS07550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MDRSPN_RS07555	COG0765	amino acid transport
MDRSPN_RS07560	COG0765	amino acid transport
MDRSPN_RS07565	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MDRSPN_RS07570	COG0191	fructose-bisphosphate aldolase activity
MDRSPN_RS07575	COG5002	protein histidine kinase activity
MDRSPN_RS07580	COG0745	RESPONSE REGULATOR receiver
MDRSPN_RS07585	COG0577	efflux transmembrane transporter activity
MDRSPN_RS07590	COG1136	(ABC) transporter
MDRSPN_RS07595	COG0577	efflux transmembrane transporter activity
MDRSPN_RS07610	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MDRSPN_RS07615	COG0215	cysteine-tRNA ligase activity
MDRSPN_RS07630	COG1045	serine acetyltransferase
MDRSPN_RS07645	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MDRSPN_RS07655	COG3620	sequence-specific DNA binding
MDRSPN_RS07670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MDRSPN_RS07670	COG0072	phenylalanine-tRNA ligase activity
MDRSPN_RS07675	COG0456	acetyltransferase
MDRSPN_RS07690	COG2190	(PTS) system
MDRSPN_RS07690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MDRSPN_RS07690	COG1263	PTS System
MDRSPN_RS07695	COG3711	transcriptional antiterminator
MDRSPN_RS07730	COG0525	valine-tRNA ligase activity
MDRSPN_RS07740	COG0519	Catalyzes the synthesis of GMP from XMP
MDRSPN_RS07800	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MDRSPN_RS07805	COG0195	Participates in both transcription termination and antitermination
MDRSPN_RS07825	COG1266	CAAX protease self-immunity
MDRSPN_RS07905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MDRSPN_RS07930	COG2226	methyltransferase
MDRSPN_RS07935	COG0799	negative regulation of ribosome biogenesis
MDRSPN_RS07945	COG1713	HD superfamily hydrolase involved in NAD metabolism
MDRSPN_RS07950	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MDRSPN_RS07955	COG1534	Rna-binding protein
MDRSPN_RS07960	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MDRSPN_RS07975	COG0668	transmembrane transport
MDRSPN_RS08005	COG3118	belongs to the thioredoxin family
MDRSPN_RS08010	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MDRSPN_RS08020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MDRSPN_RS08030	COG1164	Oligoendopeptidase f
MDRSPN_RS08105	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MDRSPN_RS08115	COG1621	beta-fructofuranosidase activity
MDRSPN_RS08120	COG1653	transport
MDRSPN_RS08125	COG0395	ABC-type sugar transport system, permease component
MDRSPN_RS08130	COG4209	transmembrane transport
MDRSPN_RS08140	COG3711	transcriptional antiterminator
MDRSPN_RS08145	COG2261	transglycosylase associated protein
MDRSPN_RS08165	COG3237	CsbD-like
MDRSPN_RS08180	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MDRSPN_RS08225	COG0512	Glutamine amidotransferase of anthranilate synthase
MDRSPN_RS08230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MDRSPN_RS08250	COG1285	pathogenesis
MDRSPN_RS08255	COG1178	ABC-type Fe3 transport system permease component
MDRSPN_RS08275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MDRSPN_RS08280	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
MDRSPN_RS08285	COG0704	Plays a role in the regulation of phosphate uptake
MDRSPN_RS08295	COG5434	Belongs to the glycosyl hydrolase 28 family
MDRSPN_RS08305	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MDRSPN_RS08310	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MDRSPN_RS08315	COG1132	(ABC) transporter
MDRSPN_RS08320	COG1132	(ABC) transporter
MDRSPN_RS08340	COG0708	Exodeoxyribonuclease III
MDRSPN_RS08360	COG2233	PERMEase
MDRSPN_RS08385	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MDRSPN_RS08390	COG1609	Transcriptional regulator
MDRSPN_RS08395	COG1063	alcohol dehydrogenase
MDRSPN_RS08400	COG0789	Transcriptional regulator
MDRSPN_RS08405	COG1230	cation diffusion facilitator family transporter
MDRSPN_RS08415	COG3201	nicotinamide mononucleotide transporter
MDRSPN_RS08420	COG1174	glycine betaine transport
MDRSPN_RS08445	COG1363	Peptidase, m42
MDRSPN_RS08460	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MDRSPN_RS08465	COG4605	iron ion homeostasis
MDRSPN_RS08470	COG4604	ABC transporter, ATP-binding protein
MDRSPN_RS08475	COG4607	ABC-type enterochelin transport system periplasmic component
MDRSPN_RS08485	COG1187	pseudouridine synthase activity
MDRSPN_RS08505	COG0517	IMP dehydrogenase activity
MDRSPN_RS08515	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MDRSPN_RS08530	COG0366	Alpha amylase catalytic
MDRSPN_RS08540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MDRSPN_RS08540	COG1263	PTS System
MDRSPN_RS08545	COG2188	Transcriptional regulator
MDRSPN_RS08565	COG4608	Belongs to the ABC transporter superfamily
MDRSPN_RS08570	COG0444	Belongs to the ABC transporter superfamily
MDRSPN_RS08575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MDRSPN_RS08580	COG0601	transmembrane transport
MDRSPN_RS08585	COG4166	transmembrane transport
MDRSPN_RS08595	COG0366	Alpha amylase catalytic
MDRSPN_RS08600	COG0395	ABC-type sugar transport system, permease component
MDRSPN_RS08605	COG1175	transmembrane transport
MDRSPN_RS08610	COG1653	transport
MDRSPN_RS08620	COG3345	alpha-galactosidase
MDRSPN_RS08625	COG2207	Transcriptional regulator
MDRSPN_RS08630	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MDRSPN_RS08630	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MDRSPN_RS08745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MDRSPN_RS08800	COG4221	oxidoreductase activity
MDRSPN_RS08805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MDRSPN_RS08810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MDRSPN_RS08905	COG3842	ATPase activity
MDRSPN_RS08910	COG1178	ABC-type Fe3 transport system permease component
MDRSPN_RS08915	COG1285	pathogenesis
MDRSPN_RS08975	COG5263	repeat protein
MDRSPN_RS08975	COG5632	N-Acetylmuramoyl-L-alanine amidase
MDRSPN_RS09000	COG1316	TRANSCRIPTIONal
MDRSPN_RS09010	COG0802	atpase or kinase
MDRSPN_RS09050	COG1674	ftsk spoiiie
MDRSPN_RS09090	COG0791	NLP P60 protein
MDRSPN_RS09090	COG0741	lytic transglycosylase activity
MDRSPN_RS09190	COG1136	(ABC) transporter
MDRSPN_RS09190	COG0577	efflux transmembrane transporter activity
MDRSPN_RS09215	COG1253	flavin adenine dinucleotide binding
MDRSPN_RS09230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MDRSPN_RS09240	COG3480	Lon protease (S16) C-terminal proteolytic domain
MDRSPN_RS09250	COG0742	ribosomal rna small subunit methyltransferase
MDRSPN_RS09270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MDRSPN_RS09275	COG1254	Belongs to the acylphosphatase family
MDRSPN_RS09285	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MDRSPN_RS09295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MDRSPN_RS09315	COG1564	THIamine pyrophosphokinase
MDRSPN_RS09325	COG1162	GTPase activity
MDRSPN_RS09350	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MDRSPN_RS09355	COG0084	hydrolase, TatD family'
MDRSPN_RS09380	COG0436	Aminotransferase
MDRSPN_RS09390	COG0589	response to stress
MDRSPN_RS09395	COG0561	phosphatase activity
MDRSPN_RS09400	COG0252	asparaginase activity
MDRSPN_RS09405	COG1609	Transcriptional regulator
MDRSPN_RS09410	COG2197	response regulator
MDRSPN_RS09415	COG4585	Histidine kinase
MDRSPN_RS09420	COG0842	Transport permease protein
MDRSPN_RS09425	COG1131	(ABC) transporter
MDRSPN_RS09530	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MDRSPN_RS09535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MDRSPN_RS09540	COG0564	pseudouridine synthase activity
MDRSPN_RS09550	COG0577	efflux transmembrane transporter activity
MDRSPN_RS09560	COG0157	Belongs to the NadC ModD family
MDRSPN_RS09575	COG1129	ABC transporter
MDRSPN_RS09580	COG2188	Transcriptional regulator
MDRSPN_RS09585	COG2723	6-phospho-beta-galactosidase activity
MDRSPN_RS09590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MDRSPN_RS09600	COG1447	Phosphotransferase system cellobiose-specific component IIA
MDRSPN_RS09605	COG1454	alcohol dehydrogenase
MDRSPN_RS09605	COG1012	belongs to the aldehyde dehydrogenase family
MDRSPN_RS09615	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MDRSPN_RS09625	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MDRSPN_RS09645	COG3623	hexulose-6-phosphate isomerase
MDRSPN_RS09655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MDRSPN_RS09665	COG3037	sugar-specific permease SgaT UlaA
MDRSPN_RS09675	COG1847	R3H domain protein
MDRSPN_RS09680	COG0706	membrane insertase activity
MDRSPN_RS09725	COG4537	Required for transformation and DNA binding
MDRSPN_RS09730	COG1459	type II secretion system
MDRSPN_RS09735	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MDRSPN_RS09745	COG1063	alcohol dehydrogenase
MDRSPN_RS09775	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MDRSPN_RS09780	COG3759	membrane
MDRSPN_RS09795	COG0131	Imidazoleglycerol-phosphate dehydratase
MDRSPN_RS09795	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MDRSPN_RS09800	COG0534	Mate efflux family protein
MDRSPN_RS09915	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MDRSPN_RS09920	COG1132	(ABC) transporter
MDRSPN_RS09930	COG1132	(ABC) transporter
MDRSPN_RS09940	COG1438	arginine binding
MDRSPN_RS09960	COG0745	RESPONSE REGULATOR receiver
MDRSPN_RS09965	COG5002	protein histidine kinase activity
MDRSPN_RS09970	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MDRSPN_RS09975	COG0573	inorganic phosphate transmembrane transporter activity
MDRSPN_RS09985	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MDRSPN_RS09990	COG0704	Plays a role in the regulation of phosphate uptake
MDRSPN_RS10010	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MDRSPN_RS10020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MDRSPN_RS10035	COG0697	spore germination
MDRSPN_RS10040	COG4499	WXG100 protein secretion system (Wss), protein YukC
MDRSPN_RS10040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MDRSPN_RS10050	COG2217	Heavy metal translocating P-type atpase
MDRSPN_RS10060	COG2226	methyltransferase
MDRSPN_RS10080	COG0058	SHG alpha-glucan phosphorylase activity
MDRSPN_RS10085	COG1640	4-alpha-glucanotransferase
MDRSPN_RS10090	COG2182	Extracellular solute-binding protein
MDRSPN_RS10095	COG1175	transmembrane transport
MDRSPN_RS10100	COG3833	ABC-type maltose transport systems, permease component
MDRSPN_RS10110	COG5521	maltodextrose utilization protein MalA
MDRSPN_RS10115	COG1609	Transcriptional regulator
MDRSPN_RS10120	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MDRSPN_RS10155	COG1476	TRANSCRIPTIONal
MDRSPN_RS10175	COG1396	sequence-specific DNA binding
MDRSPN_RS10185	COG2151	metal-sulfur cluster biosynthetic enzyme
MDRSPN_RS10195	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MDRSPN_RS10200	COG3959	Transketolase, thiamine diphosphate binding domain
MDRSPN_RS10215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MDRSPN_RS10235	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MDRSPN_RS10270	COG0383	alpha-mannosidase activity
MDRSPN_RS10280	COG3537	Alpha-1,2-mannosidase
MDRSPN_RS10305	COG0549	Belongs to the carbamate kinase family
MDRSPN_RS10310	COG1288	antiporter activity
MDRSPN_RS10315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MDRSPN_RS10330	COG3064	Membrane
MDRSPN_RS10330	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MDRSPN_RS10330	COG3583	domain protein
MDRSPN_RS10345	COG1454	alcohol dehydrogenase
MDRSPN_RS10355	COG0235	Class ii aldolase
MDRSPN_RS10385	COG1175	transmembrane transport
MDRSPN_RS10390	COG1653	transport
MDRSPN_RS10395	COG1070	Carbohydrate kinase
MDRSPN_RS10410	COG3443	Belongs to the bacterial solute-binding protein 9 family
MDRSPN_RS10410	COG0803	Belongs to the bacterial solute-binding protein 9 family
MDRSPN_RS10415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MDRSPN_RS10420	COG1121	(ABC) transporter
MDRSPN_RS10425	COG1846	Transcriptional regulator
MDRSPN_RS10430	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MDRSPN_RS10440	COG1696	Membrane protein involved in D-alanine export
MDRSPN_RS10455	COG2211	Major facilitator Superfamily
MDRSPN_RS10460	COG3344	reverse transcriptase
MDRSPN_RS10490	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MDRSPN_RS10495	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MDRSPN_RS10515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MDRSPN_RS10540	COG1755	Isoprenylcysteine carboxyl methyltransferase
MDRSPN_RS10545	COG5002	protein histidine kinase activity
MDRSPN_RS10550	COG0745	RESPONSE REGULATOR receiver
MDRSPN_RS10565	COG0542	response to heat
MDRSPN_RS10570	COG4463	regulation of RNA biosynthetic process
MDRSPN_RS10575	COG1116	anion transmembrane transporter activity
MDRSPN_RS10580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MDRSPN_RS10585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MDRSPN_RS10605	COG0305	Participates in initiation and elongation during chromosome replication
MDRSPN_RS10625	COG1040	competence protein
MDRSPN_RS10630	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MDRSPN_RS10635	COG1739	Uncharacterized protein family UPF0029
MDRSPN_RS10675	COG3942	CHAP domain
MDRSPN_RS10685	COG1792	Involved in formation and maintenance of cell shape
MDRSPN_RS10690	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MDRSPN_RS10695	COG1122	ATPase activity
MDRSPN_RS10700	COG1122	ATPase activity
MDRSPN_RS10705	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MDRSPN_RS10715	COG0612	Peptidase, M16
MDRSPN_RS10720	COG0612	Peptidase, M16
MDRSPN_RS10725	COG2501	S4 domain
MDRSPN_RS10735	COG0516	GMP reductase activity
MDRSPN_RS10735	COG0517	IMP dehydrogenase activity
MDRSPN_RS10740	COG0180	Tryptophanyl-tRNA synthetase
MDRSPN_RS10745	COG0488	(ABC) transporter
MDRSPN_RS10805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MDRSPN_RS10810	COG1475	DNA binding