locus-tag	class	description
OTU47_RS00065	COG3620	sequence-specific DNA binding
OTU47_RS00090	COG1396	sequence-specific DNA binding
OTU47_RS00115	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
OTU47_RS00170	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
OTU47_RS00175	COG0439	Biotin carboxylase
OTU47_RS00190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OTU47_RS00195	COG1028	Short-chain dehydrogenase reductase Sdr
OTU47_RS00200	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
OTU47_RS00210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OTU47_RS00220	COG1846	Transcriptional regulator
OTU47_RS00225	COG1024	Enoyl-CoA hydratase
OTU47_RS00230	COG0527	aspartate kinase activity
OTU47_RS00255	COG1115	amino acid carrier protein
OTU47_RS00280	COG0681	Belongs to the peptidase S26 family
OTU47_RS00290	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OTU47_RS00305	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
OTU47_RS00310	COG3711	transcriptional antiterminator
OTU47_RS00315	COG2213	PTS system mannitol-specific
OTU47_RS00350	COG2197	response regulator
OTU47_RS00355	COG4585	Histidine kinase
OTU47_RS00410	COG0745	RESPONSE REGULATOR receiver
OTU47_RS00415	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
OTU47_RS00425	COG0116	Belongs to the methyltransferase superfamily
OTU47_RS00450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OTU47_RS00455	COG0366	Alpha amylase catalytic
OTU47_RS00460	COG4166	transmembrane transport
OTU47_RS00520	COG1216	Glycosyl transferase, family 2
OTU47_RS00520	COG1442	glycosyl transferase family 8
OTU47_RS00525	COG1216	Glycosyl transferase, family 2
OTU47_RS00540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OTU47_RS00575	COG4166	transmembrane transport
OTU47_RS00580	COG0366	Alpha amylase catalytic
OTU47_RS00605	COG0768	penicillin binding
OTU47_RS00610	COG4839	cell division protein FtsL
OTU47_RS00640	COG1609	Transcriptional regulator
OTU47_RS00655	COG3716	PTS system mannose fructose sorbose family IID component
OTU47_RS00660	COG3715	PTS system
OTU47_RS00665	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OTU47_RS00670	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
OTU47_RS00680	COG1028	Short-chain dehydrogenase reductase Sdr
OTU47_RS00715	COG0386	Belongs to the glutathione peroxidase family
OTU47_RS00740	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
OTU47_RS00750	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OTU47_RS00750	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
OTU47_RS00760	COG0285	dihydrofolate synthase activity
OTU47_RS00765	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OTU47_RS00775	COG2252	PERMEase
OTU47_RS00780	COG0561	phosphatase activity
OTU47_RS00785	COG1064	alcohol dehydrogenase
OTU47_RS00795	COG3715	PTS system
OTU47_RS00800	COG3716	PTS system mannose fructose sorbose family IID component
OTU47_RS00805	COG3579	cysteine-type endopeptidase activity
OTU47_RS00810	COG1187	pseudouridine synthase activity
OTU47_RS00815	COG2261	transglycosylase associated protein
OTU47_RS00820	COG2309	aminopeptidase activity
OTU47_RS00840	COG2176	DNA-directed DNA polymerase activity
OTU47_RS00860	COG1523	belongs to the glycosyl hydrolase 13 family
OTU47_RS00870	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OTU47_RS00875	COG2723	6-phospho-beta-galactosidase activity
OTU47_RS00885	COG0750	zinc metalloprotease
OTU47_RS00890	COG4589	Belongs to the CDS family
OTU47_RS00895	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
OTU47_RS00940	COG1882	Formate acetyltransferase
OTU47_RS00945	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OTU47_RS00950	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OTU47_RS00955	COG1447	Phosphotransferase system cellobiose-specific component IIA
OTU47_RS00965	COG1349	DNA-binding transcription factor activity
OTU47_RS00970	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
OTU47_RS00985	COG3842	ATPase activity
OTU47_RS01005	COG3830	Belongs to the UPF0237 family
OTU47_RS01015	COG0202	RNA polymerase activity
OTU47_RS01020	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
OTU47_RS01030	COG0257	Belongs to the bacterial ribosomal protein bL36 family
OTU47_RS01035	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
OTU47_RS01045	COG0201	protein transport
OTU47_RS01060	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
OTU47_RS01100	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
OTU47_RS01125	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
OTU47_RS01160	COG0602	queuosine metabolic process
OTU47_RS01190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OTU47_RS01200	COG0285	dihydrofolate synthase activity
OTU47_RS01225	COG1393	Belongs to the ArsC family
OTU47_RS01230	COG0006	proline dipeptidase activity
OTU47_RS01235	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OTU47_RS01260	COG2818	Glycosylase
OTU47_RS01280	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OTU47_RS01280	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OTU47_RS01315	COG1780	Probably involved in ribonucleotide reductase function
OTU47_RS01325	COG4753	response regulator
OTU47_RS01325	COG2207	Transcriptional regulator
OTU47_RS01330	COG2972	Histidine kinase
OTU47_RS01350	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OTU47_RS01355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OTU47_RS01360	COG1464	Belongs to the NlpA lipoprotein family
OTU47_RS01365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OTU47_RS01400	COG1396	sequence-specific DNA binding
OTU47_RS01430	COG0438	transferase activity, transferring glycosyl groups
OTU47_RS01460	COG1214	PFAM Peptidase M22, glycoprotease
OTU47_RS01490	COG0445	tRNA wobble uridine modification
OTU47_RS01495	COG0494	nUDIX hydrolase
OTU47_RS01595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OTU47_RS01625	COG1760	l-serine dehydratase
OTU47_RS01630	COG1760	l-serine dehydratase
OTU47_RS01635	COG0546	phosphoglycolate phosphatase activity
OTU47_RS01660	COG1695	Transcriptional regulator
OTU47_RS01690	COG1653	transport
OTU47_RS01695	COG0395	ABC-type sugar transport system, permease component
OTU47_RS01700	COG4209	transmembrane transport
OTU47_RS01735	COG3843	relaxase mobilization nuclease domain protein
OTU47_RS01785	COG3942	CHAP domain
OTU47_RS01785	COG1388	LysM domain
OTU47_RS01850	COG3620	sequence-specific DNA binding
OTU47_RS01875	COG1396	sequence-specific DNA binding
OTU47_RS01895	COG5002	protein histidine kinase activity
OTU47_RS01920	COG0569	domain protein
OTU47_RS01925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OTU47_RS01935	COG0110	maltose O-acetyltransferase activity
OTU47_RS01940	COG2514	catechol 2,3-dioxygenase activity
OTU47_RS01945	COG3583	domain protein
OTU47_RS01960	COG2222	sugar isomerase
OTU47_RS01970	COG3716	PTS system mannose fructose sorbose family IID component
OTU47_RS01975	COG3715	PTS system
OTU47_RS01980	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OTU47_RS01995	COG3064	Membrane
OTU47_RS01995	COG3583	domain protein
OTU47_RS01995	COG3525	Glycosyl hydrolase, family 20, catalytic domain
OTU47_RS02000	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
OTU47_RS02015	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
OTU47_RS02025	COG0151	Belongs to the GarS family
OTU47_RS02040	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
OTU47_RS02045	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
OTU47_RS02050	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
OTU47_RS02055	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OTU47_RS02065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OTU47_RS02070	COG2274	protein secretion by the type I secretion system
OTU47_RS02095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OTU47_RS02110	COG0436	Aminotransferase
OTU47_RS02115	COG2855	membrane
OTU47_RS02120	COG1832	CoA-binding protein
OTU47_RS02125	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OTU47_RS02125	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OTU47_RS02140	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OTU47_RS02155	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
OTU47_RS02165	COG0756	dUTP diphosphatase activity
OTU47_RS02230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OTU47_RS02235	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
OTU47_RS02260	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
OTU47_RS02265	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
OTU47_RS02275	COG0012	GTP binding
OTU47_RS02285	COG0592	DNA-directed DNA polymerase activity
OTU47_RS02295	COG1475	DNA binding
OTU47_RS02300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OTU47_RS02345	COG1511	domain protein
OTU47_RS02355	COG1511	domain protein
OTU47_RS02365	COG0488	(ABC) transporter
OTU47_RS02370	COG0180	Tryptophanyl-tRNA synthetase
OTU47_RS02375	COG0517	IMP dehydrogenase activity
OTU47_RS02375	COG0516	GMP reductase activity
OTU47_RS02385	COG2501	S4 domain
OTU47_RS02390	COG0612	Peptidase, M16
OTU47_RS02395	COG0612	Peptidase, M16
OTU47_RS02405	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OTU47_RS02410	COG1122	ATPase activity
OTU47_RS02415	COG1122	ATPase activity
OTU47_RS02420	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
OTU47_RS02425	COG1792	Involved in formation and maintenance of cell shape
OTU47_RS02435	COG3942	CHAP domain
OTU47_RS02470	COG1739	Uncharacterized protein family UPF0029
OTU47_RS02475	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
OTU47_RS02480	COG1040	competence protein
OTU47_RS02500	COG0305	Participates in initiation and elongation during chromosome replication
OTU47_RS02520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OTU47_RS02525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OTU47_RS02530	COG1116	anion transmembrane transporter activity
OTU47_RS02535	COG4463	regulation of RNA biosynthetic process
OTU47_RS02540	COG0542	response to heat
OTU47_RS02545	COG0745	RESPONSE REGULATOR receiver
OTU47_RS02550	COG5002	protein histidine kinase activity
OTU47_RS02555	COG1755	Isoprenylcysteine carboxyl methyltransferase
OTU47_RS02565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OTU47_RS02585	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
OTU47_RS02590	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OTU47_RS02610	COG2211	Major facilitator Superfamily
OTU47_RS02625	COG1696	Membrane protein involved in D-alanine export
OTU47_RS02635	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
OTU47_RS02640	COG1846	Transcriptional regulator
OTU47_RS02645	COG1121	(ABC) transporter
OTU47_RS02650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OTU47_RS02655	COG3443	Belongs to the bacterial solute-binding protein 9 family
OTU47_RS02655	COG0803	Belongs to the bacterial solute-binding protein 9 family
OTU47_RS02665	COG1070	Carbohydrate kinase
OTU47_RS02670	COG1653	transport
OTU47_RS02675	COG1175	transmembrane transport
OTU47_RS02705	COG0235	Class ii aldolase
OTU47_RS02715	COG1454	alcohol dehydrogenase
OTU47_RS02725	COG3583	domain protein
OTU47_RS02725	COG3064	Membrane
OTU47_RS02725	COG3525	Glycosyl hydrolase, family 20, catalytic domain
OTU47_RS02735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OTU47_RS02740	COG1288	antiporter activity
OTU47_RS02745	COG0549	Belongs to the carbamate kinase family
OTU47_RS02775	COG0383	alpha-mannosidase activity
OTU47_RS02795	COG0267	Belongs to the bacterial ribosomal protein bL33 family
OTU47_RS02815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OTU47_RS02830	COG3959	Transketolase, thiamine diphosphate binding domain
OTU47_RS02835	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
OTU47_RS02850	COG2151	metal-sulfur cluster biosynthetic enzyme
OTU47_RS02875	COG1476	TRANSCRIPTIONal
OTU47_RS02910	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OTU47_RS02920	COG1609	Transcriptional regulator
OTU47_RS02925	COG5521	maltodextrose utilization protein MalA
OTU47_RS02930	COG4974	Belongs to the 'phage' integrase family
OTU47_RS03035	COG3833	ABC-type maltose transport systems, permease component
OTU47_RS03040	COG1175	transmembrane transport
OTU47_RS03045	COG2182	Extracellular solute-binding protein
OTU47_RS03050	COG1640	4-alpha-glucanotransferase
OTU47_RS03055	COG0058	SHG alpha-glucan phosphorylase activity
OTU47_RS03070	COG2226	methyltransferase
OTU47_RS03080	COG2217	Heavy metal translocating P-type atpase
OTU47_RS03090	COG4499	WXG100 protein secretion system (Wss), protein YukC
OTU47_RS03090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OTU47_RS03095	COG0697	spore germination
OTU47_RS03110	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
OTU47_RS03125	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OTU47_RS03150	COG0704	Plays a role in the regulation of phosphate uptake
OTU47_RS03155	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OTU47_RS03165	COG0573	inorganic phosphate transmembrane transporter activity
OTU47_RS03170	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
OTU47_RS03175	COG5002	protein histidine kinase activity
OTU47_RS03180	COG0745	RESPONSE REGULATOR receiver
OTU47_RS03200	COG1438	arginine binding
OTU47_RS03210	COG1132	(ABC) transporter
OTU47_RS03220	COG1132	(ABC) transporter
OTU47_RS03225	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
OTU47_RS03330	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OTU47_RS03345	COG0582	viral genome integration into host DNA
OTU47_RS03385	COG0534	Mate efflux family protein
OTU47_RS03390	COG0131	Imidazoleglycerol-phosphate dehydratase
OTU47_RS03390	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
OTU47_RS03405	COG3759	membrane
OTU47_RS03410	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
OTU47_RS03435	COG1063	alcohol dehydrogenase
OTU47_RS03445	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OTU47_RS03450	COG1459	type II secretion system
OTU47_RS03460	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
OTU47_RS03505	COG3561	AntA/AntB antirepressor
OTU47_RS03620	COG0582	viral genome integration into host DNA
OTU47_RS03745	COG5632	N-Acetylmuramoyl-L-alanine amidase
OTU47_RS03745	COG5263	repeat protein
OTU47_RS03755	COG4537	Required for transformation and DNA binding
OTU47_RS03805	COG0706	membrane insertase activity
OTU47_RS03810	COG1847	R3H domain protein
OTU47_RS03820	COG3037	sugar-specific permease SgaT UlaA
OTU47_RS03830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OTU47_RS03840	COG3623	hexulose-6-phosphate isomerase
OTU47_RS03860	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
OTU47_RS03870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OTU47_RS03880	COG1454	alcohol dehydrogenase
OTU47_RS03880	COG1012	belongs to the aldehyde dehydrogenase family
OTU47_RS03885	COG1447	Phosphotransferase system cellobiose-specific component IIA
OTU47_RS03895	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OTU47_RS03905	COG2188	Transcriptional regulator
OTU47_RS03910	COG1129	ABC transporter
OTU47_RS03925	COG0157	Belongs to the NadC ModD family
OTU47_RS03935	COG0577	efflux transmembrane transporter activity
OTU47_RS03945	COG0564	pseudouridine synthase activity
OTU47_RS03950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OTU47_RS03955	COG0267	Belongs to the bacterial ribosomal protein bL33 family
OTU47_RS04055	COG1131	(ABC) transporter
OTU47_RS04060	COG0842	Transport permease protein
OTU47_RS04065	COG4585	Histidine kinase
OTU47_RS04070	COG2197	response regulator
OTU47_RS04075	COG1609	Transcriptional regulator
OTU47_RS04085	COG0252	asparaginase activity
OTU47_RS04090	COG0561	phosphatase activity
OTU47_RS04095	COG0589	response to stress
OTU47_RS04105	COG0436	Aminotransferase
OTU47_RS04120	COG0084	hydrolase, TatD family'
OTU47_RS04125	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
OTU47_RS04160	COG1162	GTPase activity
OTU47_RS04170	COG1564	THIamine pyrophosphokinase
OTU47_RS04185	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
OTU47_RS04195	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
OTU47_RS04205	COG1254	Belongs to the acylphosphatase family
OTU47_RS04210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OTU47_RS04225	COG0742	ribosomal rna small subunit methyltransferase
OTU47_RS04235	COG3480	Lon protease (S16) C-terminal proteolytic domain
OTU47_RS04245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OTU47_RS04260	COG1253	flavin adenine dinucleotide binding
OTU47_RS04290	COG1136	(ABC) transporter
OTU47_RS04290	COG0577	efflux transmembrane transporter activity
OTU47_RS04315	COG0802	atpase or kinase
OTU47_RS04325	COG1316	TRANSCRIPTIONal
OTU47_RS04375	COG5632	N-Acetylmuramoyl-L-alanine amidase
OTU47_RS04375	COG5263	repeat protein
OTU47_RS04460	COG1132	(ABC) transporter
OTU47_RS04500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OTU47_RS04505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OTU47_RS04510	COG4221	oxidoreductase activity
OTU47_RS04560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OTU47_RS04675	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
OTU47_RS04675	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
OTU47_RS04680	COG2207	Transcriptional regulator
OTU47_RS04685	COG3345	alpha-galactosidase
OTU47_RS04690	COG1653	transport
OTU47_RS04695	COG1175	transmembrane transport
OTU47_RS04700	COG0395	ABC-type sugar transport system, permease component
OTU47_RS04710	COG0366	Alpha amylase catalytic
OTU47_RS04725	COG4166	transmembrane transport
OTU47_RS04730	COG0601	transmembrane transport
OTU47_RS04735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OTU47_RS04740	COG0444	Belongs to the ABC transporter superfamily
OTU47_RS04745	COG4608	Belongs to the ABC transporter superfamily
OTU47_RS04755	COG2188	Transcriptional regulator
OTU47_RS04760	COG1263	PTS System
OTU47_RS04760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OTU47_RS04765	COG0366	Alpha amylase catalytic
OTU47_RS04780	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
OTU47_RS04790	COG0517	IMP dehydrogenase activity
OTU47_RS04810	COG1187	pseudouridine synthase activity
OTU47_RS04825	COG4607	ABC-type enterochelin transport system periplasmic component
OTU47_RS04830	COG4604	ABC transporter, ATP-binding protein
OTU47_RS04835	COG4605	iron ion homeostasis
OTU47_RS04840	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OTU47_RS04850	COG1363	Peptidase, m42
OTU47_RS04875	COG1174	glycine betaine transport
OTU47_RS04880	COG3201	nicotinamide mononucleotide transporter
OTU47_RS04890	COG1230	cation diffusion facilitator family transporter
OTU47_RS04895	COG0789	Transcriptional regulator
OTU47_RS04905	COG1609	Transcriptional regulator
OTU47_RS04910	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
OTU47_RS04940	COG2233	PERMEase
OTU47_RS04960	COG0708	Exodeoxyribonuclease III
OTU47_RS04975	COG1132	(ABC) transporter
OTU47_RS04980	COG1132	(ABC) transporter
OTU47_RS04985	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
OTU47_RS04990	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
OTU47_RS04995	COG5434	Belongs to the glycosyl hydrolase 28 family
OTU47_RS05025	COG1178	ABC-type Fe3 transport system permease component
OTU47_RS05030	COG1285	pathogenesis
OTU47_RS05050	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
OTU47_RS05055	COG0512	Glutamine amidotransferase of anthranilate synthase
OTU47_RS05100	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
OTU47_RS05110	COG1940	carbohydrate kinase activity
OTU47_RS05110	COG1846	Transcriptional regulator
OTU47_RS05115	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OTU47_RS05125	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OTU47_RS05130	COG1447	Phosphotransferase system cellobiose-specific component IIA
OTU47_RS05140	COG1262	PFAM Formylglycine-generating sulfatase enzyme
OTU47_RS05160	COG3237	CsbD-like
OTU47_RS05180	COG2261	transglycosylase associated protein
OTU47_RS05185	COG3711	transcriptional antiterminator
OTU47_RS05190	COG1609	Transcriptional regulator
OTU47_RS05200	COG1175	transmembrane transport
OTU47_RS05205	COG0395	ABC-type sugar transport system, permease component
OTU47_RS05210	COG1621	beta-fructofuranosidase activity
OTU47_RS05220	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
OTU47_RS05255	COG1051	belongs to the nudix hydrolase family
OTU47_RS05265	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OTU47_RS05270	COG1164	Oligoendopeptidase f
OTU47_RS05280	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OTU47_RS05290	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
OTU47_RS05295	COG3118	belongs to the thioredoxin family
OTU47_RS05310	COG4129	membrane
OTU47_RS05320	COG0668	transmembrane transport
OTU47_RS05335	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
OTU47_RS05340	COG1534	Rna-binding protein
OTU47_RS05345	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
OTU47_RS05350	COG1713	HD superfamily hydrolase involved in NAD metabolism
OTU47_RS05360	COG0799	negative regulation of ribosome biogenesis
OTU47_RS05365	COG2226	methyltransferase
OTU47_RS05385	COG0194	GDP metabolic process
OTU47_RS05395	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
OTU47_RS05405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OTU47_RS05405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
OTU47_RS05410	COG0631	protein serine/threonine phosphatase activity
OTU47_RS05415	COG0515	serine threonine protein kinase
OTU47_RS05415	COG2815	serine threonine protein kinase
OTU47_RS05440	COG3425	synthase
OTU47_RS05450	COG1609	Transcriptional regulator
OTU47_RS05455	COG1621	beta-fructofuranosidase activity
OTU47_RS05460	COG2190	(PTS) system
OTU47_RS05460	COG1263	PTS System
OTU47_RS05460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OTU47_RS05465	COG1940	carbohydrate kinase activity
OTU47_RS05485	COG4152	abc transporter atp-binding protein
OTU47_RS05490	COG1668	transmembrane transport
OTU47_RS05500	COG1131	(ABC) transporter
OTU47_RS05505	COG1725	Transcriptional regulator
OTU47_RS05520	COG1484	DNA-dependent DNA replication
OTU47_RS05525	COG0778	Nitroreductase
OTU47_RS05555	COG1131	(ABC) transporter
OTU47_RS05570	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OTU47_RS05575	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OTU47_RS05590	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
OTU47_RS05595	COG3458	cephalosporin-C deacetylase activity
OTU47_RS05615	COG1653	transport
OTU47_RS05620	COG1175	transmembrane transport
OTU47_RS05630	COG4409	exo-alpha-(2->6)-sialidase activity
OTU47_RS05635	COG0673	inositol 2-dehydrogenase activity
OTU47_RS05645	COG2190	(PTS) system
OTU47_RS05645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OTU47_RS05645	COG1263	PTS System
OTU47_RS05655	COG1175	transmembrane transport
OTU47_RS05660	COG0395	ABC-type sugar transport system, permease component
OTU47_RS05665	COG2731	YhcH YjgK YiaL family protein
OTU47_RS05680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OTU47_RS05695	COG0768	penicillin binding
OTU47_RS05710	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OTU47_RS05715	COG1051	belongs to the nudix hydrolase family
OTU47_RS05735	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
OTU47_RS05755	COG3599	regulation of cell shape
OTU47_RS05780	COG1136	(ABC) transporter
OTU47_RS05780	COG0577	efflux transmembrane transporter activity
OTU47_RS05790	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
OTU47_RS05795	COG0803	Belongs to the bacterial solute-binding protein 9 family
OTU47_RS05810	COG3590	peptidase
OTU47_RS05850	COG1959	2 iron, 2 sulfur cluster binding
OTU47_RS05865	COG0745	RESPONSE REGULATOR receiver
OTU47_RS05870	COG5002	protein histidine kinase activity
OTU47_RS05905	COG0204	Acyl-transferase
OTU47_RS05910	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
OTU47_RS05915	COG2384	SAM-dependent methyltransferase
OTU47_RS05920	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
OTU47_RS05925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OTU47_RS05935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OTU47_RS05940	COG0463	Glycosyl transferase, family 2
OTU47_RS05960	COG2824	Alkylphosphonate utilization operon protein PhnA
OTU47_RS05980	COG0351	phosphomethylpyrimidine kinase
OTU47_RS05985	COG4720	Psort location CytoplasmicMembrane, score
OTU47_RS06000	COG0006	proline dipeptidase activity
OTU47_RS06005	COG3442	glutamine amidotransferase
OTU47_RS06010	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OTU47_RS06015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OTU47_RS06020	COG2223	nitrite transmembrane transporter activity
OTU47_RS06025	COG0513	Belongs to the DEAD box helicase family
OTU47_RS06035	COG1335	isochorismatase
OTU47_RS06045	COG3842	ATPase activity
OTU47_RS06055	COG2226	methyltransferase
OTU47_RS06070	COG3935	DnaD domain protein
OTU47_RS06090	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
OTU47_RS06110	COG0251	oxidation-reduction process
OTU47_RS06120	COG0391	Required for morphogenesis under gluconeogenic growth conditions
OTU47_RS06125	COG1481	regulation of sporulation
OTU47_RS06130	COG0582	viral genome integration into host DNA
OTU47_RS06320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OTU47_RS06425	COG5632	N-Acetylmuramoyl-L-alanine amidase
OTU47_RS06425	COG5263	repeat protein
OTU47_RS06435	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
OTU47_RS06455	COG1307	EDD domain protein, DegV family
OTU47_RS06465	COG0617	tRNA 3'-terminal CCA addition
OTU47_RS06470	COG0488	(ABC) transporter
OTU47_RS06475	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
OTU47_RS06485	COG0625	glutathione transferase activity
OTU47_RS06490	COG0242	peptide deformylase activity
OTU47_RS06520	COG0436	Aminotransferase
OTU47_RS06530	COG0017	Asparaginyl-tRNA synthetase
OTU47_RS06540	COG0629	single-stranded DNA binding
OTU47_RS06545	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
OTU47_RS06555	COG1098	S1 RNA binding domain
OTU47_RS06560	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
OTU47_RS06565	COG2827	Endonuclease containing a URI domain
OTU47_RS06590	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OTU47_RS06595	COG2244	polysaccharide biosynthetic process
OTU47_RS06600	COG4166	transmembrane transport
OTU47_RS06620	COG0626	cystathionine gamma-synthase activity
OTU47_RS06625	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
OTU47_RS06630	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
OTU47_RS06655	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
OTU47_RS06715	COG2706	6-phosphogluconolactonase activity
OTU47_RS06720	COG0628	permease
OTU47_RS06735	COG1126	abc transporter atp-binding protein
OTU47_RS06740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OTU47_RS06750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OTU47_RS06775	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OTU47_RS06805	COG0726	polysaccharide deacetylase
OTU47_RS06810	COG0656	L-ascorbic acid biosynthetic process
OTU47_RS06835	COG0431	NADPH-dependent FMN reductase
OTU47_RS06835	COG3976	FMN-binding domain protein
OTU47_RS06835	COG1053	succinate dehydrogenase
OTU47_RS06865	COG1272	protein, Hemolysin III
OTU47_RS06885	COG1393	Belongs to the ArsC family
OTU47_RS06895	COG1126	abc transporter atp-binding protein
OTU47_RS06905	COG0492	ferredoxin-NADP+ reductase activity
OTU47_RS06930	COG0561	phosphatase activity
OTU47_RS06945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
OTU47_RS06950	COG0697	spore germination
OTU47_RS06955	COG2188	Transcriptional regulator
OTU47_RS06975	COG0826	peptidase U32
OTU47_RS07010	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
OTU47_RS07020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OTU47_RS07065	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OTU47_RS07075	COG0647	UMP catabolic process
OTU47_RS07085	COG1393	Belongs to the ArsC family
OTU47_RS07095	COG0483	inositol monophosphate 1-phosphatase activity
OTU47_RS07100	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
OTU47_RS07100	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
OTU47_RS07105	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
OTU47_RS07110	COG0573	inorganic phosphate transmembrane transporter activity
OTU47_RS07115	COG0581	inorganic phosphate transmembrane transporter activity
OTU47_RS07120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OTU47_RS07125	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OTU47_RS07130	COG0704	Plays a role in the regulation of phosphate uptake
OTU47_RS07135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OTU47_RS07140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OTU47_RS07145	COG3527	Alpha-acetolactate decarboxylase
OTU47_RS07160	COG3842	ATPase activity
OTU47_RS07200	COG1131	(ABC) transporter
OTU47_RS07210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
OTU47_RS07235	COG0287	Prephenate dehydrogenase
OTU47_RS07250	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
OTU47_RS07255	COG0077	Prephenate dehydratase
OTU47_RS07265	COG3475	LICD family
OTU47_RS07275	COG1215	transferase activity, transferring glycosyl groups
OTU47_RS07310	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OTU47_RS07310	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OTU47_RS07315	COG1132	(ABC) transporter
OTU47_RS07330	COG0402	S-adenosylhomocysteine deaminase activity
OTU47_RS07400	COG1136	(ABC) transporter
OTU47_RS07490	COG1131	(ABC) transporter
OTU47_RS07585	COG0542	response to heat
OTU47_RS07635	COG3843	relaxase mobilization nuclease domain protein
OTU47_RS07665	COG1674	ftsk spoiiie
OTU47_RS07675	COG2946	Replication initiation factor
OTU47_RS07705	COG0791	NLP P60 protein
OTU47_RS07705	COG0741	lytic transglycosylase activity
OTU47_RS07760	COG0515	serine threonine protein kinase
OTU47_RS07770	COG0577	efflux transmembrane transporter activity
OTU47_RS07770	COG1136	(ABC) transporter
OTU47_RS07805	COG0785	Cytochrome C biogenesis protein
OTU47_RS07810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OTU47_RS07815	COG0531	amino acid
OTU47_RS07820	COG0803	Belongs to the bacterial solute-binding protein 9 family
OTU47_RS07820	COG3443	Belongs to the bacterial solute-binding protein 9 family
OTU47_RS07850	COG2195	Cleaves the N-terminal amino acid of tripeptides
OTU47_RS07855	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
OTU47_RS07860	COG1970	mechanosensitive ion channel activity
OTU47_RS07870	COG4708	membrane
OTU47_RS07880	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OTU47_RS07890	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
OTU47_RS07895	COG1942	4-Oxalocrotonate Tautomerase
OTU47_RS07900	COG1435	thymidine kinase activity
OTU47_RS07910	COG2890	protein-(glutamine-N5) methyltransferase activity
OTU47_RS07935	COG0741	lytic transglycosylase activity
OTU47_RS07945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OTU47_RS07970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OTU47_RS07975	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OTU47_RS08050	COG1597	lipid kinase activity
OTU47_RS08100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OTU47_RS08115	COG1396	sequence-specific DNA binding
OTU47_RS08125	COG0772	Belongs to the SEDS family
OTU47_RS08130	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
OTU47_RS08145	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OTU47_RS08150	COG0358	DNA primase activity
OTU47_RS08155	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OTU47_RS08160	COG2151	metal-sulfur cluster biosynthetic enzyme
OTU47_RS08165	COG0438	transferase activity, transferring glycosyl groups
OTU47_RS08170	COG0438	transferase activity, transferring glycosyl groups
OTU47_RS08195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OTU47_RS08205	COG4109	DRTGG domain
OTU47_RS08210	COG0024	Methionine aminopeptidase
OTU47_RS08220	COG0210	DNA helicase
OTU47_RS08230	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
OTU47_RS08250	COG1104	cysteine desulfurase activity
OTU47_RS08255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OTU47_RS08265	COG2357	RelA SpoT domain protein
OTU47_RS08275	COG0564	pseudouridine synthase activity
OTU47_RS08280	COG0280	phosphate acetyltransferase
OTU47_RS08320	COG0196	riboflavin kinase activity
OTU47_RS08325	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OTU47_RS08330	COG1307	EDD domain protein, DegV family
OTU47_RS08340	COG0488	(ABC) transporter
OTU47_RS08370	COG1523	belongs to the glycosyl hydrolase 13 family
OTU47_RS08375	COG1012	belongs to the aldehyde dehydrogenase family
OTU47_RS08380	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
OTU47_RS08390	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
OTU47_RS08400	COG0560	Phosphoserine phosphatase
OTU47_RS08405	COG0560	Phosphoserine phosphatase
OTU47_RS08425	COG0582	viral genome integration into host DNA
OTU47_RS08465	COG3064	Membrane
OTU47_RS08475	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
OTU47_RS08495	COG0095	Lipoate-protein ligase
OTU47_RS08500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OTU47_RS08505	COG0508	dehydrogenase complex catalyzes the overall conversion of
OTU47_RS08510	COG0022	dehydrogenase e1 component
OTU47_RS08515	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
OTU47_RS08520	COG0534	Mate efflux family protein
OTU47_RS08530	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
OTU47_RS08535	COG1051	belongs to the nudix hydrolase family
OTU47_RS08550	COG1011	Hydrolase
OTU47_RS08575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OTU47_RS08580	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
OTU47_RS08585	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OTU47_RS08590	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OTU47_RS08605	COG2723	6-phospho-beta-galactosidase activity
OTU47_RS08620	COG3711	transcriptional antiterminator
OTU47_RS08625	COG3684	Belongs to the aldolase LacD family
OTU47_RS08670	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OTU47_RS08675	COG0497	DNA recombination
OTU47_RS08680	COG1438	arginine binding
OTU47_RS08685	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
OTU47_RS08715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
OTU47_RS08745	COG3764	Sortase (surface protein transpeptidase)
OTU47_RS08750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
OTU47_RS08760	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OTU47_RS08775	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
OTU47_RS08780	COG5002	protein histidine kinase activity
OTU47_RS08785	COG0745	RESPONSE REGULATOR receiver
OTU47_RS08790	COG1194	a g-specific adenine glycosylase
OTU47_RS08810	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
OTU47_RS08815	COG4684	Psort location CytoplasmicMembrane, score
OTU47_RS08825	COG1827	regulation of RNA biosynthetic process
OTU47_RS08855	COG0765	amino acid transport
OTU47_RS08860	COG1126	abc transporter atp-binding protein
OTU47_RS08865	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
OTU47_RS08870	COG0552	protein localization to endoplasmic reticulum
OTU47_RS08875	COG0561	phosphatase activity
OTU47_RS08880	COG0561	phosphatase activity
OTU47_RS08915	COG0189	ligase activity
OTU47_RS08920	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OTU47_RS08930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OTU47_RS08935	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
OTU47_RS08940	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
OTU47_RS08945	COG0574	Belongs to the PEP-utilizing enzyme family
OTU47_RS08945	COG3848	Pyruvate phosphate dikinase
OTU47_RS08965	COG1196	nuclear chromosome segregation
OTU47_RS08990	COG1401	restriction endodeoxyribonuclease activity
OTU47_RS09000	COG0066	3-isopropylmalate dehydratase activity
OTU47_RS09010	COG0473	3-isopropylmalate dehydrogenase activity
OTU47_RS09030	COG3142	Participates in the control of copper homeostasis
OTU47_RS09035	COG2832	Protein of unknown function (DUF454)
OTU47_RS09040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OTU47_RS09055	COG0758	DNA mediated transformation
OTU47_RS09060	COG4750	Nucleotidyl transferase
OTU47_RS09075	COG1063	alcohol dehydrogenase
OTU47_RS09090	COG3475	LICD family
OTU47_RS09095	COG3475	LICD family
OTU47_RS09105	COG0505	Belongs to the CarA family
OTU47_RS09120	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
OTU47_RS09135	COG0488	(ABC) transporter
OTU47_RS09145	COG1704	LemA family
OTU47_RS09160	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OTU47_RS09175	COG1078	dGTPase activity
OTU47_RS09195	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
OTU47_RS09200	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
OTU47_RS09205	COG1605	Chorismate mutase
OTU47_RS09205	COG0077	Prephenate dehydratase
OTU47_RS09210	COG0716	FMN binding
OTU47_RS09215	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
OTU47_RS09235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
OTU47_RS09310	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OTU47_RS09315	COG1269	ATP hydrolysis coupled proton transport
OTU47_RS09330	COG0673	inositol 2-dehydrogenase activity
OTU47_RS09335	COG4409	exo-alpha-(2->6)-sialidase activity
OTU47_RS09345	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OTU47_RS09350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OTU47_RS09355	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
OTU47_RS09360	COG1737	Transcriptional regulator
OTU47_RS09395	COG0584	glycerophosphoryl diester phosphodiesterase
OTU47_RS09400	COG2176	DNA-directed DNA polymerase activity
OTU47_RS09410	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
OTU47_RS09420	COG0494	nUDIX hydrolase
OTU47_RS09440	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OTU47_RS09465	COG4122	O-methyltransferase activity
OTU47_RS09480	COG0500	methyltransferase
OTU47_RS09480	COG3615	Tellurite resistance protein tehB
OTU47_RS09490	COG0557	exoribonuclease II activity
OTU47_RS09505	COG2814	Major facilitator Superfamily
OTU47_RS09510	COG0237	dephospho-CoA kinase activity
OTU47_RS09515	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
OTU47_RS09525	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
OTU47_RS09535	COG1293	RNA-binding protein homologous to eukaryotic snRNP
OTU47_RS09540	COG5263	repeat protein
OTU47_RS09540	COG4193	domain, Protein
OTU47_RS09545	COG0167	dihydroorotate dehydrogenase activity
OTU47_RS09550	COG0543	2 iron, 2 sulfur cluster binding
OTU47_RS09580	COG1131	(ABC) transporter
OTU47_RS09590	COG2333	competence protein COMEC
OTU47_RS09590	COG0658	competence protein
OTU47_RS09595	COG1555	photosystem II stabilization
OTU47_RS09595	COG1596	polysaccharide export
OTU47_RS09600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OTU47_RS09620	COG1702	phosphate starvation-inducible protein PhoH
OTU47_RS09630	COG2996	Protein conserved in bacteria
OTU47_RS09640	COG0528	UMP kinase activity
OTU47_RS09685	COG0470	DNA polymerase III
OTU47_RS09695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
OTU47_RS09710	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
OTU47_RS09715	COG0564	pseudouridine synthase activity
OTU47_RS09720	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
OTU47_RS09725	COG0583	DNA-binding transcription factor activity
OTU47_RS09745	COG0561	phosphatase activity
OTU47_RS09750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OTU47_RS09770	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
OTU47_RS09780	COG1982	Orn Lys Arg decarboxylase major
OTU47_RS09795	COG0577	efflux transmembrane transporter activity
OTU47_RS09800	COG1136	(ABC) transporter
OTU47_RS09820	COG2183	response to ionizing radiation
OTU47_RS09835	COG0701	Predicted permease
OTU47_RS09840	COG3689	TIGRFAM TIGR03943 family protein
OTU47_RS09870	COG0469	pyruvate kinase activity
OTU47_RS09890	COG1438	arginine binding
OTU47_RS09895	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
OTU47_RS09960	COG1104	cysteine desulfurase activity
OTU47_RS09970	COG1674	ftsk spoiiie
OTU47_RS09970	COG0697	spore germination
OTU47_RS09975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OTU47_RS09975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OTU47_RS09975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OTU47_RS09980	COG1105	Belongs to the carbohydrate kinase PfkB family
OTU47_RS09985	COG1349	DNA-binding transcription factor activity
OTU47_RS10000	COG0628	permease
OTU47_RS10005	COG1686	Belongs to the peptidase S11 family
OTU47_RS10010	COG0719	Fe-S assembly protein
OTU47_RS10020	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OTU47_RS10025	COG0719	Fe-S assembly protein
OTU47_RS10040	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
OTU47_RS10045	COG1956	GAF domain-containing protein
OTU47_RS10055	COG0539	negative regulation of cytoplasmic translation
OTU47_RS10090	COG4166	transmembrane transport
OTU47_RS10095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OTU47_RS10100	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
OTU47_RS10110	COG0187	DNA topoisomerase II activity
OTU47_RS10125	COG1079	Belongs to the binding-protein-dependent transport system permease family
OTU47_RS10130	COG4603	Belongs to the binding-protein-dependent transport system permease family
OTU47_RS10135	COG3845	ABC transporter
OTU47_RS10140	COG1744	ABC transporter substrate-binding protein PnrA-like
OTU47_RS10145	COG0295	cytidine deaminase activity
OTU47_RS10155	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
OTU47_RS10160	COG2813	Specifically methylates the guanine in position
OTU47_RS10205	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
OTU47_RS10225	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OTU47_RS10230	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
OTU47_RS10235	COG1126	abc transporter atp-binding protein
OTU47_RS10240	COG0765	amino acid transport
OTU47_RS10245	COG4703	Protein of unknown function (DUF1797)
OTU47_RS10250	COG0542	response to heat
OTU47_RS10280	COG0187	DNA topoisomerase II activity
OTU47_RS10290	COG0693	protein deglycase activity
OTU47_RS10295	COG0772	Belongs to the SEDS family
OTU47_RS10315	COG5002	protein histidine kinase activity
OTU47_RS10320	COG0745	RESPONSE REGULATOR receiver
OTU47_RS10345	COG1028	Short-chain dehydrogenase reductase Sdr
OTU47_RS10355	COG4989	oxidoreductase activity
OTU47_RS10375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OTU47_RS10375	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OTU47_RS10380	COG0577	efflux transmembrane transporter activity
OTU47_RS10385	COG1136	(ABC) transporter
OTU47_RS10390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OTU47_RS10395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OTU47_RS10400	COG1268	BioY protein
OTU47_RS10410	COG4443	Transcriptional Coactivator p15 (PC4)
OTU47_RS10420	COG1328	CTP reductase activity
OTU47_RS10420	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
OTU47_RS10445	COG1837	Belongs to the UPF0109 family
OTU47_RS10470	COG0488	(ABC) transporter
OTU47_RS10485	COG4470	Protein conserved in bacteria
OTU47_RS10490	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OTU47_RS10500	COG0167	dihydroorotate dehydrogenase activity
OTU47_RS10510	COG0513	Belongs to the DEAD box helicase family
OTU47_RS10520	COG2190	(PTS) system
OTU47_RS10520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OTU47_RS10520	COG1263	PTS System
OTU47_RS10525	COG2177	Part of the ABC transporter FtsEX involved in
OTU47_RS10530	COG2884	Cell division ATP-binding protein ftsE
OTU47_RS10540	COG0617	tRNA 3'-terminal CCA addition
OTU47_RS10540	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
OTU47_RS10540	COG0517	IMP dehydrogenase activity
OTU47_RS10580	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
OTU47_RS10585	COG2131	deaminase
OTU47_RS10595	COG1307	EDD domain protein, DegV family
OTU47_RS10600	COG2081	HI0933 family
OTU47_RS10610	COG0789	Transcriptional regulator
OTU47_RS10615	COG0733	neurotransmitter:sodium symporter activity
OTU47_RS10620	COG1482	cell wall glycoprotein biosynthetic process
OTU47_RS10640	COG0028	Belongs to the TPP enzyme family
OTU47_RS10645	COG2217	Heavy metal translocating P-type atpase
OTU47_RS10665	COG0352	thiamine-phosphate diphosphorylase activity
OTU47_RS10680	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OTU47_RS10690	COG1122	ATPase activity
OTU47_RS10700	COG0352	thiamine-phosphate diphosphorylase activity
OTU47_RS10720	COG1304	FMN binding
OTU47_RS10730	COG1304	FMN binding
OTU47_RS10755	COG1131	(ABC) transporter
OTU47_RS10780	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
OTU47_RS10785	COG0284	orotidine-5'-phosphate decarboxylase activity
OTU47_RS10790	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
OTU47_RS10795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OTU47_RS10805	COG1136	(ABC) transporter
OTU47_RS10825	COG1217	gtp-binding protein TYPA
OTU47_RS10830	COG1187	pseudouridine synthase activity
OTU47_RS10840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OTU47_RS10855	COG0300	oxidoreductase activity
OTU47_RS10865	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
OTU47_RS10870	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
OTU47_RS10890	COG1940	carbohydrate kinase activity
OTU47_RS10905	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
OTU47_RS10910	COG3064	Membrane
OTU47_RS10920	COG2972	Histidine kinase
OTU47_RS10925	COG2207	Transcriptional regulator
OTU47_RS10925	COG4753	response regulator
OTU47_RS10930	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OTU47_RS10930	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OTU47_RS10935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OTU47_RS10940	COG0785	Cytochrome C biogenesis protein
OTU47_RS10960	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
OTU47_RS10985	COG3250	beta-galactosidase activity
OTU47_RS10995	COG3775	system Galactitol-specific IIC component
OTU47_RS11010	COG1404	Belongs to the peptidase S8 family
OTU47_RS11035	COG4555	ABC transporter
OTU47_RS11080	COG1363	Peptidase, m42
OTU47_RS11085	COG1114	Component of the transport system for branched-chain amino acids
OTU47_RS11095	COG1573	uracil-dna glycosylase
OTU47_RS11110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OTU47_RS11150	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
OTU47_RS11150	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
OTU47_RS11160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OTU47_RS11165	COG0765	amino acid transport
OTU47_RS11170	COG0765	amino acid transport
OTU47_RS11175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OTU47_RS11180	COG0191	fructose-bisphosphate aldolase activity
OTU47_RS11185	COG5002	protein histidine kinase activity
OTU47_RS11190	COG0745	RESPONSE REGULATOR receiver
OTU47_RS11200	COG0577	efflux transmembrane transporter activity
OTU47_RS11205	COG1136	(ABC) transporter
OTU47_RS11210	COG0577	efflux transmembrane transporter activity
OTU47_RS11230	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
OTU47_RS11235	COG0215	cysteine-tRNA ligase activity
OTU47_RS11245	COG1045	serine acetyltransferase
OTU47_RS11260	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
OTU47_RS11265	COG3620	sequence-specific DNA binding
OTU47_RS11280	COG0072	phenylalanine-tRNA ligase activity
OTU47_RS11280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OTU47_RS11285	COG0456	acetyltransferase
OTU47_RS11300	COG2190	(PTS) system
OTU47_RS11300	COG1263	PTS System
OTU47_RS11300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OTU47_RS11305	COG3711	transcriptional antiterminator
OTU47_RS11325	COG0525	valine-tRNA ligase activity
OTU47_RS11335	COG0519	Catalyzes the synthesis of GMP from XMP
OTU47_RS11400	COG2740	Nucleic-acid-binding protein implicated in transcription termination
OTU47_RS11405	COG0195	Participates in both transcription termination and antitermination
OTU47_RS11425	COG1266	CAAX protease self-immunity
OTU47_RS11515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OTU47_RS11525	COG3290	protein histidine kinase activity
OTU47_RS11550	COG1131	(ABC) transporter
OTU47_RS11555	COG0537	adenosine 5'-monophosphoramidase activity
OTU47_RS11565	COG0484	heat shock protein binding
OTU47_RS11620	COG4974	Belongs to the 'phage' integrase family
OTU47_RS11640	COG0174	glutamine synthetase
OTU47_RS11645	COG0789	Transcriptional regulator
OTU47_RS11665	COG1283	sodium-dependent phosphate transmembrane transporter activity
OTU47_RS11670	COG0504	CTP synthase activity
OTU47_RS11685	COG1247	-acetyltransferase
OTU47_RS11695	COG0671	phosphoesterase, PA-phosphatase related
OTU47_RS11700	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
OTU47_RS11715	COG1122	ATPase activity
OTU47_RS11735	COG0569	domain protein
OTU47_RS11740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OTU47_RS11745	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OTU47_RS11745	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OTU47_RS11750	COG2723	6-phospho-beta-galactosidase activity
OTU47_RS11755	COG1447	Phosphotransferase system cellobiose-specific component IIA
OTU47_RS11765	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OTU47_RS11770	COG1846	Transcriptional regulator
OTU47_RS11770	COG1940	carbohydrate kinase activity
OTU47_RS11790	COG1882	Formate acetyltransferase
OTU47_RS11800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OTU47_RS11820	COG0765	amino acid transport
OTU47_RS11835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OTU47_RS11855	COG0440	acetolactate synthase activity
OTU47_RS11860	COG0028	Belongs to the TPP enzyme family
OTU47_RS11865	COG1461	Dihydroxyacetone kinase
OTU47_RS11875	COG0227	Belongs to the bacterial ribosomal protein bL28 family
OTU47_RS11885	COG3843	relaxase mobilization nuclease domain protein
OTU47_RS11935	COG1388	LysM domain
OTU47_RS11935	COG3942	CHAP domain