locus-tag	class	description
spnnt_RS00010	COG0592	DNA-directed DNA polymerase activity
spnnt_RS00095	COG4974	Belongs to the 'phage' integrase family
spnnt_RS00100	COG0012	GTP binding
spnnt_RS00110	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
spnnt_RS00115	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
spnnt_RS00140	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
spnnt_RS00145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
spnnt_RS00215	COG0756	dUTP diphosphatase activity
spnnt_RS00225	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
spnnt_RS00240	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
spnnt_RS00255	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
spnnt_RS00255	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
spnnt_RS00260	COG1832	CoA-binding protein
spnnt_RS00265	COG2855	membrane
spnnt_RS00270	COG0436	Aminotransferase
spnnt_RS00285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
spnnt_RS00330	COG1134	teichoic acid transport
spnnt_RS00330	COG1388	LysM domain
spnnt_RS00345	COG2274	protein secretion by the type I secretion system
spnnt_RS00350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
spnnt_RS00360	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
spnnt_RS00375	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
spnnt_RS00390	COG0151	Belongs to the GarS family
spnnt_RS00395	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
spnnt_RS00410	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
spnnt_RS00430	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
spnnt_RS00435	COG3715	PTS system
spnnt_RS00440	COG3716	PTS system mannose fructose sorbose family IID component
spnnt_RS00450	COG2222	sugar isomerase
spnnt_RS00475	COG3335	DDE superfamily endonuclease
spnnt_RS00480	COG3583	domain protein
spnnt_RS00485	COG2514	catechol 2,3-dioxygenase activity
spnnt_RS00490	COG0110	maltose O-acetyltransferase activity
spnnt_RS00510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
spnnt_RS00515	COG0569	domain protein
spnnt_RS00520	COG1215	transferase activity, transferring glycosyl groups
spnnt_RS00540	COG5002	protein histidine kinase activity
spnnt_RS00550	COG4209	transmembrane transport
spnnt_RS00555	COG0395	ABC-type sugar transport system, permease component
spnnt_RS00565	COG1653	transport
spnnt_RS00595	COG1695	Transcriptional regulator
spnnt_RS00615	COG2801	Transposase and inactivated derivatives
spnnt_RS00630	COG0546	phosphoglycolate phosphatase activity
spnnt_RS00635	COG1760	l-serine dehydratase
spnnt_RS00640	COG1760	l-serine dehydratase
spnnt_RS00645	COG1705	Flagellar rod assembly protein muramidase FlgJ
spnnt_RS00645	COG1388	LysM domain
spnnt_RS00655	COG2274	protein secretion by the type I secretion system
spnnt_RS00730	COG0494	nUDIX hydrolase
spnnt_RS00735	COG0445	tRNA wobble uridine modification
spnnt_RS00755	COG2801	Transposase and inactivated derivatives
spnnt_RS00770	COG1214	PFAM Peptidase M22, glycoprotease
spnnt_RS00780	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
spnnt_RS00785	COG1396	sequence-specific DNA binding
spnnt_RS00820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
spnnt_RS00825	COG1464	Belongs to the NlpA lipoprotein family
spnnt_RS00830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
spnnt_RS00835	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
spnnt_RS00860	COG4753	response regulator
spnnt_RS00860	COG2207	Transcriptional regulator
spnnt_RS00870	COG1780	Probably involved in ribonucleotide reductase function
spnnt_RS00900	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
spnnt_RS00900	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
spnnt_RS00920	COG2818	Glycosylase
spnnt_RS00945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
spnnt_RS00950	COG0006	proline dipeptidase activity
spnnt_RS00960	COG0006	proline dipeptidase activity
spnnt_RS00965	COG1393	Belongs to the ArsC family
spnnt_RS00990	COG0285	dihydrofolate synthase activity
spnnt_RS01000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
spnnt_RS01015	COG1328	CTP reductase activity
spnnt_RS01030	COG0602	queuosine metabolic process
spnnt_RS01065	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
spnnt_RS01090	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
spnnt_RS01130	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
spnnt_RS01145	COG0201	protein transport
spnnt_RS01155	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
spnnt_RS01160	COG0257	Belongs to the bacterial ribosomal protein bL36 family
spnnt_RS01170	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
spnnt_RS01175	COG0202	RNA polymerase activity
spnnt_RS01185	COG3830	Belongs to the UPF0237 family
spnnt_RS01205	COG1178	ABC-type Fe3 transport system permease component
spnnt_RS01230	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
spnnt_RS01235	COG1349	DNA-binding transcription factor activity
spnnt_RS01245	COG2801	Transposase and inactivated derivatives
spnnt_RS01255	COG1447	Phosphotransferase system cellobiose-specific component IIA
spnnt_RS01260	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
spnnt_RS01265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
spnnt_RS01270	COG1882	Formate acetyltransferase
spnnt_RS01325	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
spnnt_RS01330	COG4589	Belongs to the CDS family
spnnt_RS01335	COG0750	zinc metalloprotease
spnnt_RS01345	COG2723	6-phospho-beta-galactosidase activity
spnnt_RS01350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
spnnt_RS01355	COG2213	PTS system mannitol-specific
spnnt_RS01360	COG3711	transcriptional antiterminator
spnnt_RS01365	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
spnnt_RS01380	COG1523	belongs to the glycosyl hydrolase 13 family
spnnt_RS01405	COG2176	DNA-directed DNA polymerase activity
spnnt_RS01425	COG2309	aminopeptidase activity
spnnt_RS01430	COG2261	transglycosylase associated protein
spnnt_RS01435	COG1187	pseudouridine synthase activity
spnnt_RS01445	COG3579	cysteine-type endopeptidase activity
spnnt_RS01450	COG3716	PTS system mannose fructose sorbose family IID component
spnnt_RS01455	COG3715	PTS system
spnnt_RS01465	COG1064	alcohol dehydrogenase
spnnt_RS01470	COG0561	phosphatase activity
spnnt_RS01475	COG2252	PERMEase
spnnt_RS01485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
spnnt_RS01490	COG0285	dihydrofolate synthase activity
spnnt_RS01500	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
spnnt_RS01500	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
spnnt_RS01510	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
spnnt_RS01535	COG0386	Belongs to the glutathione peroxidase family
spnnt_RS01565	COG1028	Short-chain dehydrogenase reductase Sdr
spnnt_RS01575	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
spnnt_RS01580	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
spnnt_RS01585	COG3715	PTS system
spnnt_RS01590	COG3716	PTS system mannose fructose sorbose family IID component
spnnt_RS01605	COG1609	Transcriptional regulator
spnnt_RS01640	COG4839	cell division protein FtsL
spnnt_RS01645	COG0768	penicillin binding
spnnt_RS01670	COG0366	Alpha amylase catalytic
spnnt_RS01675	COG4166	transmembrane transport
spnnt_RS01680	COG4166	transmembrane transport
spnnt_RS01705	COG4166	transmembrane transport
spnnt_RS01710	COG2801	Transposase and inactivated derivatives
spnnt_RS01720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
spnnt_RS01745	COG0116	Belongs to the methyltransferase superfamily
spnnt_RS01755	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
spnnt_RS01760	COG0745	RESPONSE REGULATOR receiver
spnnt_RS01820	COG4585	Histidine kinase
spnnt_RS01825	COG2197	response regulator
spnnt_RS01865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
spnnt_RS01870	COG0681	Belongs to the peptidase S26 family
spnnt_RS01895	COG1115	amino acid carrier protein
spnnt_RS01920	COG0527	aspartate kinase activity
spnnt_RS01960	COG1024	Enoyl-CoA hydratase
spnnt_RS01970	COG1846	Transcriptional regulator
spnnt_RS01980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
spnnt_RS01990	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
spnnt_RS01995	COG1028	Short-chain dehydrogenase reductase Sdr
spnnt_RS02000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
spnnt_RS02015	COG0439	Biotin carboxylase
spnnt_RS02020	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
spnnt_RS02055	COG1063	alcohol dehydrogenase
spnnt_RS02075	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
spnnt_RS02085	COG0227	Belongs to the bacterial ribosomal protein bL28 family
spnnt_RS02095	COG1461	Dihydroxyacetone kinase
spnnt_RS02100	COG0028	Belongs to the TPP enzyme family
spnnt_RS02105	COG0440	acetolactate synthase activity
spnnt_RS02125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
spnnt_RS02140	COG0765	amino acid transport
spnnt_RS02170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
spnnt_RS02175	COG1882	Formate acetyltransferase
spnnt_RS02220	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
spnnt_RS02225	COG0569	domain protein
spnnt_RS02245	COG1122	ATPase activity
spnnt_RS02260	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
spnnt_RS02265	COG0671	phosphoesterase, PA-phosphatase related
spnnt_RS02275	COG1247	-acetyltransferase
spnnt_RS02285	COG0504	CTP synthase activity
spnnt_RS02310	COG0789	Transcriptional regulator
spnnt_RS02315	COG0174	glutamine synthetase
spnnt_RS02330	COG4974	Belongs to the 'phage' integrase family
spnnt_RS02340	COG0732	type I restriction modification DNA specificity domain
spnnt_RS02385	COG0484	heat shock protein binding
spnnt_RS02400	COG0537	adenosine 5'-monophosphoramidase activity
spnnt_RS02405	COG1131	(ABC) transporter
spnnt_RS02410	COG4473	ABC transporter
spnnt_RS02430	COG3290	protein histidine kinase activity
spnnt_RS02440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
spnnt_RS02445	COG2274	protein secretion by the type I secretion system
spnnt_RS02505	COG1266	CAAX protease self-immunity
spnnt_RS02525	COG0195	Participates in both transcription termination and antitermination
spnnt_RS02530	COG2740	Nucleic-acid-binding protein implicated in transcription termination
spnnt_RS02590	COG0519	Catalyzes the synthesis of GMP from XMP
spnnt_RS02600	COG0525	valine-tRNA ligase activity
spnnt_RS02630	COG2801	Transposase and inactivated derivatives
spnnt_RS02635	COG2801	Transposase and inactivated derivatives
spnnt_RS02670	COG3711	transcriptional antiterminator
spnnt_RS02675	COG2190	(PTS) system
spnnt_RS02675	COG1263	PTS System
spnnt_RS02675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
spnnt_RS02690	COG0456	acetyltransferase
spnnt_RS02695	COG0072	phenylalanine-tRNA ligase activity
spnnt_RS02695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
spnnt_RS02715	COG3620	sequence-specific DNA binding
spnnt_RS02720	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
spnnt_RS02730	COG1185	polyribonucleotide nucleotidyltransferase activity
spnnt_RS02735	COG1045	serine acetyltransferase
spnnt_RS02745	COG0215	cysteine-tRNA ligase activity
spnnt_RS02750	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
spnnt_RS02785	COG0577	efflux transmembrane transporter activity
spnnt_RS02790	COG1136	(ABC) transporter
spnnt_RS02795	COG0577	efflux transmembrane transporter activity
spnnt_RS02800	COG0745	RESPONSE REGULATOR receiver
spnnt_RS02805	COG5002	protein histidine kinase activity
spnnt_RS02810	COG0191	fructose-bisphosphate aldolase activity
spnnt_RS02815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
spnnt_RS02820	COG0765	amino acid transport
spnnt_RS02825	COG0765	amino acid transport
spnnt_RS02830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
spnnt_RS02840	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
spnnt_RS02840	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
spnnt_RS02880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
spnnt_RS02895	COG1573	uracil-dna glycosylase
spnnt_RS02905	COG1114	Component of the transport system for branched-chain amino acids
spnnt_RS02910	COG1363	Peptidase, m42
spnnt_RS02990	COG0270	DNA (cytosine-5-)-methyltransferase activity
spnnt_RS03100	COG3177	Filamentation induced by cAMP protein fic
spnnt_RS03140	COG1396	sequence-specific DNA binding
spnnt_RS03145	COG0542	response to heat
spnnt_RS03175	COG3843	relaxase mobilization nuclease domain protein
spnnt_RS03185	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
spnnt_RS03270	COG1404	Belongs to the peptidase S8 family
spnnt_RS03295	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
spnnt_RS03315	COG0785	Cytochrome C biogenesis protein
spnnt_RS03320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
spnnt_RS03325	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
spnnt_RS03325	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
spnnt_RS03330	COG2207	Transcriptional regulator
spnnt_RS03330	COG4753	response regulator
spnnt_RS03335	COG2972	Histidine kinase
spnnt_RS03345	COG3064	Membrane
spnnt_RS03355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
spnnt_RS03370	COG1940	carbohydrate kinase activity
spnnt_RS03390	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
spnnt_RS03395	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
spnnt_RS03405	COG0300	oxidoreductase activity
spnnt_RS03420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
spnnt_RS03430	COG1187	pseudouridine synthase activity
spnnt_RS03435	COG1217	gtp-binding protein TYPA
spnnt_RS03455	COG1136	(ABC) transporter
spnnt_RS03470	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
spnnt_RS03500	COG2826	transposase and inactivated derivatives, IS30 family
spnnt_RS03510	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
spnnt_RS03535	COG1131	(ABC) transporter
spnnt_RS03550	COG1304	FMN binding
spnnt_RS03560	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
spnnt_RS03565	COG0352	thiamine-phosphate diphosphorylase activity
spnnt_RS03575	COG4172	Belongs to the ABC transporter superfamily
spnnt_RS03585	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
spnnt_RS03600	COG0352	thiamine-phosphate diphosphorylase activity
spnnt_RS03620	COG2217	Heavy metal translocating P-type atpase
spnnt_RS03625	COG0028	Belongs to the TPP enzyme family
spnnt_RS03635	COG3335	DDE superfamily endonuclease
spnnt_RS03645	COG2723	6-phospho-beta-galactosidase activity
spnnt_RS03650	COG1482	cell wall glycoprotein biosynthetic process
spnnt_RS03665	COG0789	Transcriptional regulator
spnnt_RS03685	COG2081	HI0933 family
spnnt_RS03690	COG1307	EDD domain protein, DegV family
spnnt_RS03700	COG2131	deaminase
spnnt_RS03705	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
spnnt_RS03745	COG0517	IMP dehydrogenase activity
spnnt_RS03745	COG0617	tRNA 3'-terminal CCA addition
spnnt_RS03745	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
spnnt_RS03750	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
spnnt_RS03755	COG2884	Cell division ATP-binding protein ftsE
spnnt_RS03760	COG2177	Part of the ABC transporter FtsEX involved in
spnnt_RS03765	COG1263	PTS System
spnnt_RS03765	COG2190	(PTS) system
spnnt_RS03765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
spnnt_RS03775	COG0513	Belongs to the DEAD box helicase family
spnnt_RS03785	COG0167	dihydroorotate dehydrogenase activity
spnnt_RS03795	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
spnnt_RS03800	COG4470	Protein conserved in bacteria
spnnt_RS03815	COG0488	(ABC) transporter
spnnt_RS03840	COG1837	Belongs to the UPF0109 family
spnnt_RS03860	COG1328	CTP reductase activity
spnnt_RS03860	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
spnnt_RS03870	COG4443	Transcriptional Coactivator p15 (PC4)
spnnt_RS03880	COG1268	BioY protein
spnnt_RS03885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
spnnt_RS03890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
spnnt_RS03895	COG1136	(ABC) transporter
spnnt_RS03900	COG0577	efflux transmembrane transporter activity
spnnt_RS03905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
spnnt_RS03905	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
spnnt_RS03920	COG4989	oxidoreductase activity
spnnt_RS03930	COG1028	Short-chain dehydrogenase reductase Sdr
spnnt_RS03955	COG0745	RESPONSE REGULATOR receiver
spnnt_RS03960	COG5002	protein histidine kinase activity
spnnt_RS03980	COG0772	Belongs to the SEDS family
spnnt_RS03985	COG0693	protein deglycase activity
spnnt_RS03995	COG0187	DNA topoisomerase II activity
spnnt_RS04015	COG3335	DDE superfamily endonuclease
spnnt_RS04035	COG0726	polysaccharide deacetylase
spnnt_RS04040	COG0656	L-ascorbic acid biosynthetic process
spnnt_RS04055	COG0751	glycine-tRNA ligase activity
spnnt_RS04065	COG3976	FMN-binding domain protein
spnnt_RS04065	COG1053	succinate dehydrogenase
spnnt_RS04065	COG0431	NADPH-dependent FMN reductase
spnnt_RS04095	COG1272	protein, Hemolysin III
spnnt_RS04110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
spnnt_RS04115	COG1393	Belongs to the ArsC family
spnnt_RS04125	COG1126	abc transporter atp-binding protein
spnnt_RS04135	COG0492	ferredoxin-NADP+ reductase activity
spnnt_RS04170	COG0561	phosphatase activity
spnnt_RS04185	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
spnnt_RS04190	COG0697	spore germination
spnnt_RS04195	COG2188	Transcriptional regulator
spnnt_RS04265	COG0826	peptidase U32
spnnt_RS04275	COG0826	peptidase U32
spnnt_RS04280	COG1131	(ABC) transporter
spnnt_RS04300	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
spnnt_RS04375	COG0635	Involved in the biosynthesis of porphyrin-containing compound
spnnt_RS04385	COG0647	UMP catabolic process
spnnt_RS04400	COG1393	Belongs to the ArsC family
spnnt_RS04410	COG0483	inositol monophosphate 1-phosphatase activity
spnnt_RS04415	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
spnnt_RS04415	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
spnnt_RS04420	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
spnnt_RS04425	COG0573	inorganic phosphate transmembrane transporter activity
spnnt_RS04430	COG0581	inorganic phosphate transmembrane transporter activity
spnnt_RS04435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
spnnt_RS04440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
spnnt_RS04445	COG0704	Plays a role in the regulation of phosphate uptake
spnnt_RS04450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
spnnt_RS04455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
spnnt_RS04460	COG3527	Alpha-acetolactate decarboxylase
spnnt_RS04475	COG3842	ATPase activity
spnnt_RS04480	COG1177	transmembrane transport
spnnt_RS04515	COG1131	(ABC) transporter
spnnt_RS04530	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
spnnt_RS04555	COG0287	Prephenate dehydrogenase
spnnt_RS04560	COG3679	Belongs to the UPF0342 family
spnnt_RS04570	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
spnnt_RS04575	COG0077	Prephenate dehydratase
spnnt_RS04585	COG3475	LICD family
spnnt_RS04595	COG1215	transferase activity, transferring glycosyl groups
spnnt_RS04630	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
spnnt_RS04630	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
spnnt_RS04635	COG1132	(ABC) transporter
spnnt_RS04645	COG0402	S-adenosylhomocysteine deaminase activity
spnnt_RS04670	COG0270	DNA (cytosine-5-)-methyltransferase activity
spnnt_RS04705	COG1674	ftsk spoiiie
spnnt_RS04710	COG2946	Replication initiation factor
spnnt_RS04730	COG0456	acetyltransferase
spnnt_RS04745	COG2801	Transposase and inactivated derivatives
spnnt_RS04805	COG0791	NLP P60 protein
spnnt_RS04805	COG0741	lytic transglycosylase activity
spnnt_RS04915	COG2801	Transposase and inactivated derivatives
spnnt_RS04955	COG1396	sequence-specific DNA binding
spnnt_RS04960	COG0542	response to heat
spnnt_RS04975	COG0419	ATPase involved in DNA repair
spnnt_RS05025	COG1131	(ABC) transporter
spnnt_RS05040	COG1396	sequence-specific DNA binding
spnnt_RS05055	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
spnnt_RS05095	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
spnnt_RS05100	COG0716	FMN binding
spnnt_RS05105	COG0077	Prephenate dehydratase
spnnt_RS05105	COG1605	Chorismate mutase
spnnt_RS05110	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
spnnt_RS05115	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
spnnt_RS05130	COG1396	sequence-specific DNA binding
spnnt_RS05150	COG2801	Transposase and inactivated derivatives
spnnt_RS05170	COG1078	dGTPase activity
spnnt_RS05185	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
spnnt_RS05200	COG1704	LemA family
spnnt_RS05205	COG0501	Belongs to the peptidase M48B family
spnnt_RS05210	COG0488	(ABC) transporter
spnnt_RS05215	COG0488	(ABC) transporter
spnnt_RS05240	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
spnnt_RS05260	COG0505	Belongs to the CarA family
spnnt_RS05270	COG3475	LICD family
spnnt_RS05275	COG3475	LICD family
spnnt_RS05290	COG1063	alcohol dehydrogenase
spnnt_RS05305	COG4750	Nucleotidyl transferase
spnnt_RS05310	COG0758	DNA mediated transformation
spnnt_RS05320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
spnnt_RS05325	COG2832	Protein of unknown function (DUF454)
spnnt_RS05330	COG3142	Participates in the control of copper homeostasis
spnnt_RS05345	COG0473	3-isopropylmalate dehydrogenase activity
spnnt_RS05355	COG0066	3-isopropylmalate dehydratase activity
spnnt_RS05370	COG1401	restriction endodeoxyribonuclease activity
spnnt_RS05400	COG1196	nuclear chromosome segregation
spnnt_RS05405	COG0561	phosphatase activity
spnnt_RS05410	COG0561	phosphatase activity
spnnt_RS05415	COG0552	protein localization to endoplasmic reticulum
spnnt_RS05420	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
spnnt_RS05425	COG1126	abc transporter atp-binding protein
spnnt_RS05430	COG0765	amino acid transport
spnnt_RS05460	COG1827	regulation of RNA biosynthetic process
spnnt_RS05470	COG4684	Psort location CytoplasmicMembrane, score
spnnt_RS05475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
spnnt_RS05490	COG1194	a g-specific adenine glycosylase
spnnt_RS05495	COG0745	RESPONSE REGULATOR receiver
spnnt_RS05500	COG5002	protein histidine kinase activity
spnnt_RS05505	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
spnnt_RS05520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
spnnt_RS05530	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
spnnt_RS05535	COG3764	Sortase (surface protein transpeptidase)
spnnt_RS05555	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
spnnt_RS05590	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
spnnt_RS05595	COG1438	arginine binding
spnnt_RS05600	COG0497	DNA recombination
spnnt_RS05605	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
spnnt_RS05655	COG3684	Belongs to the aldolase LacD family
spnnt_RS05665	COG3711	transcriptional antiterminator
spnnt_RS05700	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
spnnt_RS05705	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
spnnt_RS05710	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
spnnt_RS05715	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
spnnt_RS05750	COG2376	Dihydroxyacetone kinase
spnnt_RS05755	COG1309	transcriptional regulator
spnnt_RS05760	COG2376	Dihydroxyacetone kinase
spnnt_RS05765	COG1461	Dihydroxyacetone kinase
spnnt_RS05770	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
spnnt_RS05785	COG1011	Hydrolase
spnnt_RS05800	COG1051	belongs to the nudix hydrolase family
spnnt_RS05805	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
spnnt_RS05815	COG0534	Mate efflux family protein
spnnt_RS05820	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
spnnt_RS05830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
spnnt_RS05840	COG3344	reverse transcriptase
spnnt_RS05860	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
spnnt_RS05925	COG0560	Phosphoserine phosphatase
spnnt_RS05930	COG2801	Transposase and inactivated derivatives
spnnt_RS05945	COG0560	Phosphoserine phosphatase
spnnt_RS05970	COG1523	belongs to the glycosyl hydrolase 13 family
spnnt_RS05990	COG0488	(ABC) transporter
spnnt_RS06000	COG1307	EDD domain protein, DegV family
spnnt_RS06005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
spnnt_RS06010	COG0196	riboflavin kinase activity
spnnt_RS06060	COG0280	phosphate acetyltransferase
spnnt_RS06065	COG0564	pseudouridine synthase activity
spnnt_RS06075	COG2357	RelA SpoT domain protein
spnnt_RS06085	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
spnnt_RS06090	COG1104	cysteine desulfurase activity
spnnt_RS06110	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
spnnt_RS06120	COG0210	DNA helicase
spnnt_RS06140	COG0024	Methionine aminopeptidase
spnnt_RS06145	COG4109	DRTGG domain
spnnt_RS06155	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
spnnt_RS06195	COG0438	transferase activity, transferring glycosyl groups
spnnt_RS06200	COG0438	transferase activity, transferring glycosyl groups
spnnt_RS06205	COG2151	metal-sulfur cluster biosynthetic enzyme
spnnt_RS06210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
spnnt_RS06215	COG0358	DNA primase activity
spnnt_RS06225	COG1122	ATPase activity
spnnt_RS06245	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
spnnt_RS06250	COG0772	Belongs to the SEDS family
spnnt_RS06260	COG4581	dead DEAH box helicase
spnnt_RS06270	COG0542	response to heat
spnnt_RS06275	COG1396	sequence-specific DNA binding
spnnt_RS06290	COG0366	Alpha amylase catalytic
spnnt_RS06295	COG1597	lipid kinase activity
spnnt_RS06315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
spnnt_RS06325	COG0741	lytic transglycosylase activity
spnnt_RS06350	COG2890	protein-(glutamine-N5) methyltransferase activity
spnnt_RS06360	COG1435	thymidine kinase activity
spnnt_RS06365	COG1942	4-Oxalocrotonate Tautomerase
spnnt_RS06370	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
spnnt_RS06380	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
spnnt_RS06390	COG4708	membrane
spnnt_RS06400	COG1970	mechanosensitive ion channel activity
spnnt_RS06410	COG2195	Cleaves the N-terminal amino acid of tripeptides
spnnt_RS06450	COG0803	Belongs to the bacterial solute-binding protein 9 family
spnnt_RS06450	COG3443	Belongs to the bacterial solute-binding protein 9 family
spnnt_RS06455	COG0531	amino acid
spnnt_RS06460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
spnnt_RS06465	COG0785	Cytochrome C biogenesis protein
spnnt_RS06490	COG0584	glycerophosphoryl diester phosphodiesterase
spnnt_RS06495	COG2176	DNA-directed DNA polymerase activity
spnnt_RS06505	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
spnnt_RS06515	COG0494	nUDIX hydrolase
spnnt_RS06535	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
spnnt_RS06550	COG2801	Transposase and inactivated derivatives
spnnt_RS06560	COG4122	O-methyltransferase activity
spnnt_RS06575	COG0500	methyltransferase
spnnt_RS06575	COG3615	Tellurite resistance protein tehB
spnnt_RS06585	COG0557	exoribonuclease II activity
spnnt_RS06600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
spnnt_RS06605	COG2814	Major facilitator Superfamily
spnnt_RS06610	COG0237	dephospho-CoA kinase activity
spnnt_RS06615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
spnnt_RS06625	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
spnnt_RS06635	COG1293	RNA-binding protein homologous to eukaryotic snRNP
spnnt_RS06640	COG4193	domain, Protein
spnnt_RS06640	COG5263	repeat protein
spnnt_RS06645	COG0167	dihydroorotate dehydrogenase activity
spnnt_RS06650	COG0543	2 iron, 2 sulfur cluster binding
spnnt_RS06680	COG3177	Filamentation induced by cAMP protein fic
spnnt_RS06700	COG3843	relaxase mobilization nuclease domain protein
spnnt_RS06775	COG1388	LysM domain
spnnt_RS06775	COG3942	CHAP domain
spnnt_RS06850	COG1131	(ABC) transporter
spnnt_RS06860	COG2333	competence protein COMEC
spnnt_RS06860	COG0658	competence protein
spnnt_RS06865	COG1596	polysaccharide export
spnnt_RS06865	COG1555	photosystem II stabilization
spnnt_RS06870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
spnnt_RS06875	COG0686	Belongs to the AlaDH PNT family
spnnt_RS06880	COG0686	Belongs to the AlaDH PNT family
spnnt_RS06895	COG1702	phosphate starvation-inducible protein PhoH
spnnt_RS06905	COG2996	Protein conserved in bacteria
spnnt_RS06915	COG0528	UMP kinase activity
spnnt_RS06965	COG0470	DNA polymerase III
spnnt_RS06975	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
spnnt_RS07000	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
spnnt_RS07005	COG0564	pseudouridine synthase activity
spnnt_RS07010	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
spnnt_RS07015	COG0583	DNA-binding transcription factor activity
spnnt_RS07035	COG0561	phosphatase activity
spnnt_RS07040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
spnnt_RS07060	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
spnnt_RS07065	COG1982	Orn Lys Arg decarboxylase major
spnnt_RS07075	COG0577	efflux transmembrane transporter activity
spnnt_RS07080	COG1136	(ABC) transporter
spnnt_RS07100	COG2183	response to ionizing radiation
spnnt_RS07115	COG0701	Predicted permease
spnnt_RS07120	COG3689	TIGRFAM TIGR03943 family protein
spnnt_RS07155	COG0582	viral genome integration into host DNA
spnnt_RS07160	COG0469	pyruvate kinase activity
spnnt_RS07180	COG1438	arginine binding
spnnt_RS07260	COG1104	cysteine desulfurase activity
spnnt_RS07270	COG0697	spore germination
spnnt_RS07270	COG1674	ftsk spoiiie
spnnt_RS07275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
spnnt_RS07275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
spnnt_RS07275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
spnnt_RS07280	COG1105	Belongs to the carbohydrate kinase PfkB family
spnnt_RS07285	COG1349	DNA-binding transcription factor activity
spnnt_RS07295	COG0628	permease
spnnt_RS07300	COG1686	Belongs to the peptidase S11 family
spnnt_RS07310	COG0719	Fe-S assembly protein
spnnt_RS07320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
spnnt_RS07325	COG0719	Fe-S assembly protein
spnnt_RS07340	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
spnnt_RS07345	COG1956	GAF domain-containing protein
spnnt_RS07365	COG0539	negative regulation of cytoplasmic translation
spnnt_RS07405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
spnnt_RS07410	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
spnnt_RS07420	COG0187	DNA topoisomerase II activity
spnnt_RS07430	COG2801	Transposase and inactivated derivatives
spnnt_RS07440	COG1079	Belongs to the binding-protein-dependent transport system permease family
spnnt_RS07445	COG4603	Belongs to the binding-protein-dependent transport system permease family
spnnt_RS07450	COG3845	ABC transporter
spnnt_RS07455	COG1744	ABC transporter substrate-binding protein PnrA-like
spnnt_RS07460	COG0295	cytidine deaminase activity
spnnt_RS07470	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
spnnt_RS07475	COG2813	Specifically methylates the guanine in position
spnnt_RS07520	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
spnnt_RS07540	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
spnnt_RS07545	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
spnnt_RS07550	COG1126	abc transporter atp-binding protein
spnnt_RS07555	COG0765	amino acid transport
spnnt_RS07560	COG4703	Protein of unknown function (DUF1797)
spnnt_RS07565	COG0542	response to heat
spnnt_RS07580	COG0494	nUDIX hydrolase
spnnt_RS07595	COG3335	DDE superfamily endonuclease
spnnt_RS07615	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
spnnt_RS07665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
spnnt_RS07675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
spnnt_RS07680	COG1126	abc transporter atp-binding protein
spnnt_RS07690	COG0457	Tetratricopeptide repeat
spnnt_RS07695	COG0628	permease
spnnt_RS07700	COG2706	6-phosphogluconolactonase activity
spnnt_RS07715	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
spnnt_RS07765	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
spnnt_RS07790	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
spnnt_RS07795	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
spnnt_RS07800	COG0626	cystathionine gamma-synthase activity
spnnt_RS07805	COG1132	(ABC) transporter
spnnt_RS07810	COG1132	(ABC) transporter
spnnt_RS07820	COG4166	transmembrane transport
spnnt_RS07825	COG2244	polysaccharide biosynthetic process
spnnt_RS07830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
spnnt_RS07855	COG2827	Endonuclease containing a URI domain
spnnt_RS07860	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
spnnt_RS07865	COG1098	S1 RNA binding domain
spnnt_RS07890	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
spnnt_RS07895	COG0629	single-stranded DNA binding
spnnt_RS07905	COG0017	Asparaginyl-tRNA synthetase
spnnt_RS07915	COG0436	Aminotransferase
spnnt_RS07955	COG0242	peptide deformylase activity
spnnt_RS07960	COG0625	glutathione transferase activity
spnnt_RS07970	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
spnnt_RS07975	COG0488	(ABC) transporter
spnnt_RS07980	COG0617	tRNA 3'-terminal CCA addition
spnnt_RS07990	COG1307	EDD domain protein, DegV family
spnnt_RS08010	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
spnnt_RS08020	COG0492	ferredoxin-NADP+ reductase activity
spnnt_RS08025	COG5263	repeat protein
spnnt_RS08025	COG5632	N-Acetylmuramoyl-L-alanine amidase
spnnt_RS08305	COG0582	viral genome integration into host DNA
spnnt_RS08310	COG1481	regulation of sporulation
spnnt_RS08315	COG0391	Required for morphogenesis under gluconeogenic growth conditions
spnnt_RS08325	COG0251	oxidation-reduction process
spnnt_RS08345	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
spnnt_RS08355	COG4193	domain, Protein
spnnt_RS08355	COG5263	repeat protein
spnnt_RS08365	COG3935	DnaD domain protein
spnnt_RS08380	COG2226	methyltransferase
spnnt_RS08390	COG3842	ATPase activity
spnnt_RS08400	COG1335	isochorismatase
spnnt_RS08405	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
spnnt_RS08410	COG0513	Belongs to the DEAD box helicase family
spnnt_RS08415	COG2223	nitrite transmembrane transporter activity
spnnt_RS08420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
spnnt_RS08425	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
spnnt_RS08430	COG3442	glutamine amidotransferase
spnnt_RS08435	COG0006	proline dipeptidase activity
spnnt_RS08440	COG2801	Transposase and inactivated derivatives
spnnt_RS08455	COG4720	Psort location CytoplasmicMembrane, score
spnnt_RS08460	COG0351	phosphomethylpyrimidine kinase
spnnt_RS08485	COG2824	Alkylphosphonate utilization operon protein PhnA
spnnt_RS08505	COG0463	Glycosyl transferase, family 2
spnnt_RS08510	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
spnnt_RS08520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
spnnt_RS08525	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
spnnt_RS08530	COG2384	SAM-dependent methyltransferase
spnnt_RS08535	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
spnnt_RS08540	COG0204	Acyl-transferase
spnnt_RS08555	COG2910	NAD(P)H-binding
spnnt_RS08580	COG5002	protein histidine kinase activity
spnnt_RS08585	COG0745	RESPONSE REGULATOR receiver
spnnt_RS08600	COG1959	2 iron, 2 sulfur cluster binding
spnnt_RS08660	COG3590	peptidase
spnnt_RS08675	COG0803	Belongs to the bacterial solute-binding protein 9 family
spnnt_RS08680	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
spnnt_RS08690	COG0577	efflux transmembrane transporter activity
spnnt_RS08690	COG1136	(ABC) transporter
spnnt_RS08735	COG3599	regulation of cell shape
spnnt_RS08755	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
spnnt_RS08775	COG1051	belongs to the nudix hydrolase family
spnnt_RS08780	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
spnnt_RS08795	COG0768	penicillin binding
spnnt_RS08810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
spnnt_RS08830	COG0395	ABC-type sugar transport system, permease component
spnnt_RS08835	COG1175	transmembrane transport
spnnt_RS08855	COG0673	inositol 2-dehydrogenase activity
spnnt_RS08860	COG4409	exo-alpha-(2->6)-sialidase activity
spnnt_RS08870	COG1175	transmembrane transport
spnnt_RS08875	COG1653	transport
spnnt_RS08905	COG3458	cephalosporin-C deacetylase activity
spnnt_RS08910	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
spnnt_RS08925	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
spnnt_RS08930	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
spnnt_RS08935	COG0653	protein targeting
spnnt_RS08945	COG1131	(ABC) transporter
spnnt_RS08975	COG0778	Nitroreductase
spnnt_RS08980	COG1484	DNA-dependent DNA replication
spnnt_RS08995	COG1725	Transcriptional regulator
spnnt_RS09000	COG1131	(ABC) transporter
spnnt_RS09010	COG1668	transmembrane transport
spnnt_RS09015	COG4152	abc transporter atp-binding protein
spnnt_RS09035	COG1940	carbohydrate kinase activity
spnnt_RS09040	COG1263	PTS System
spnnt_RS09040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
spnnt_RS09040	COG2190	(PTS) system
spnnt_RS09050	COG1621	beta-fructofuranosidase activity
spnnt_RS09055	COG1609	Transcriptional regulator
spnnt_RS09065	COG3425	synthase
spnnt_RS09095	COG2815	serine threonine protein kinase
spnnt_RS09095	COG0515	serine threonine protein kinase
spnnt_RS09100	COG0631	protein serine/threonine phosphatase activity
spnnt_RS09105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
spnnt_RS09105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
spnnt_RS09115	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
spnnt_RS09125	COG0194	GDP metabolic process
spnnt_RS09155	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
spnnt_RS09160	COG4115	mRNA cleavage
spnnt_RS09175	COG2226	methyltransferase
spnnt_RS09180	COG0799	negative regulation of ribosome biogenesis
spnnt_RS09185	COG1713	HD superfamily hydrolase involved in NAD metabolism
spnnt_RS09190	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
spnnt_RS09195	COG1534	Rna-binding protein
spnnt_RS09200	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
spnnt_RS09215	COG0668	transmembrane transport
spnnt_RS09220	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
spnnt_RS09240	COG3118	belongs to the thioredoxin family
spnnt_RS09250	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
spnnt_RS09270	COG1131	(ABC) transporter
spnnt_RS09275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
spnnt_RS09280	COG0640	Transcriptional regulator
spnnt_RS09285	COG1164	Oligoendopeptidase f
spnnt_RS09290	COG1385	rRNA (uridine-N3-)-methyltransferase activity
spnnt_RS09300	COG1051	belongs to the nudix hydrolase family
spnnt_RS09335	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
spnnt_RS09350	COG3711	transcriptional antiterminator
spnnt_RS09355	COG2261	transglycosylase associated protein
spnnt_RS09375	COG3237	CsbD-like
spnnt_RS09430	COG0512	Glutamine amidotransferase of anthranilate synthase
spnnt_RS09435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
spnnt_RS09460	COG1285	pathogenesis
spnnt_RS09465	COG1178	ABC-type Fe3 transport system permease component
spnnt_RS09485	COG5434	Belongs to the glycosyl hydrolase 28 family
spnnt_RS09500	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
spnnt_RS09505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
spnnt_RS09510	COG1132	(ABC) transporter
spnnt_RS09515	COG1132	(ABC) transporter
spnnt_RS09540	COG0708	Exodeoxyribonuclease III
spnnt_RS09560	COG2233	PERMEase
spnnt_RS09590	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
spnnt_RS09595	COG1609	Transcriptional regulator
spnnt_RS09600	COG1063	alcohol dehydrogenase
spnnt_RS09605	COG0789	Transcriptional regulator
spnnt_RS09610	COG1230	cation diffusion facilitator family transporter
spnnt_RS09620	COG3201	nicotinamide mononucleotide transporter
spnnt_RS09625	COG1174	glycine betaine transport
spnnt_RS09650	COG1363	Peptidase, m42
spnnt_RS09665	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
spnnt_RS09670	COG4605	iron ion homeostasis
spnnt_RS09675	COG4604	ABC transporter, ATP-binding protein
spnnt_RS09680	COG4607	ABC-type enterochelin transport system periplasmic component
spnnt_RS09690	COG1187	pseudouridine synthase activity
spnnt_RS09710	COG0517	IMP dehydrogenase activity
spnnt_RS09720	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
spnnt_RS09735	COG0366	Alpha amylase catalytic
spnnt_RS09740	COG1263	PTS System
spnnt_RS09740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
spnnt_RS09745	COG2188	Transcriptional regulator
spnnt_RS09755	COG4608	Belongs to the ABC transporter superfamily
spnnt_RS09760	COG0444	Belongs to the ABC transporter superfamily
spnnt_RS09765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
spnnt_RS09770	COG0601	transmembrane transport
spnnt_RS09775	COG4166	transmembrane transport
spnnt_RS09785	COG0366	Alpha amylase catalytic
spnnt_RS09790	COG0395	ABC-type sugar transport system, permease component
spnnt_RS09795	COG1175	transmembrane transport
spnnt_RS09800	COG1653	transport
spnnt_RS09805	COG3345	alpha-galactosidase
spnnt_RS09810	COG2207	Transcriptional regulator
spnnt_RS09815	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
spnnt_RS09815	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
spnnt_RS09930	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
spnnt_RS09935	COG3231	kanamycin kinase activity
spnnt_RS09985	COG4221	oxidoreductase activity
spnnt_RS09990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
spnnt_RS09995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
spnnt_RS10035	COG1132	(ABC) transporter
spnnt_RS10135	COG5263	repeat protein
spnnt_RS10135	COG5632	N-Acetylmuramoyl-L-alanine amidase
spnnt_RS10155	COG1316	TRANSCRIPTIONal
spnnt_RS10165	COG0802	atpase or kinase
spnnt_RS10205	COG1253	flavin adenine dinucleotide binding
spnnt_RS10220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
spnnt_RS10225	COG3480	Lon protease (S16) C-terminal proteolytic domain
spnnt_RS10230	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
spnnt_RS10235	COG0742	ribosomal rna small subunit methyltransferase
spnnt_RS10250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
spnnt_RS10255	COG1254	Belongs to the acylphosphatase family
spnnt_RS10265	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
spnnt_RS10275	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
spnnt_RS10290	COG1564	THIamine pyrophosphokinase
spnnt_RS10300	COG1162	GTPase activity
spnnt_RS10315	COG1136	(ABC) transporter
spnnt_RS10315	COG0577	efflux transmembrane transporter activity
spnnt_RS10330	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
spnnt_RS10335	COG0084	hydrolase, TatD family'
spnnt_RS10350	COG0436	Aminotransferase
spnnt_RS10360	COG0589	response to stress
spnnt_RS10365	COG0561	phosphatase activity
spnnt_RS10370	COG0252	asparaginase activity
spnnt_RS10375	COG1609	Transcriptional regulator
spnnt_RS10380	COG2197	response regulator
spnnt_RS10385	COG4585	Histidine kinase
spnnt_RS10390	COG0842	Transport permease protein
spnnt_RS10395	COG1131	(ABC) transporter
spnnt_RS10495	COG0267	Belongs to the bacterial ribosomal protein bL33 family
spnnt_RS10500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
spnnt_RS10505	COG0564	pseudouridine synthase activity
spnnt_RS10515	COG0577	efflux transmembrane transporter activity
spnnt_RS10530	COG0157	Belongs to the NadC ModD family
spnnt_RS10540	COG4133	protoheme IX ABC transporter activity
spnnt_RS10545	COG2188	Transcriptional regulator
spnnt_RS10555	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
spnnt_RS10565	COG1447	Phosphotransferase system cellobiose-specific component IIA
spnnt_RS10570	COG1012	belongs to the aldehyde dehydrogenase family
spnnt_RS10570	COG1454	alcohol dehydrogenase
spnnt_RS10580	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
spnnt_RS10590	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
spnnt_RS10610	COG3623	hexulose-6-phosphate isomerase
spnnt_RS10620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
spnnt_RS10630	COG3037	sugar-specific permease SgaT UlaA
spnnt_RS10640	COG1847	R3H domain protein
spnnt_RS10645	COG0706	membrane insertase activity
spnnt_RS10695	COG4537	Required for transformation and DNA binding
spnnt_RS10700	COG1459	type II secretion system
spnnt_RS10705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
spnnt_RS10740	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
spnnt_RS10745	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
spnnt_RS10760	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
spnnt_RS10760	COG0131	Imidazoleglycerol-phosphate dehydratase
spnnt_RS10765	COG0534	Mate efflux family protein
spnnt_RS10825	COG0582	viral genome integration into host DNA
spnnt_RS10830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
spnnt_RS10840	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
spnnt_RS10845	COG2801	Transposase and inactivated derivatives
spnnt_RS10955	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
spnnt_RS10960	COG1132	(ABC) transporter
spnnt_RS10970	COG1132	(ABC) transporter
spnnt_RS10980	COG1438	arginine binding
spnnt_RS11000	COG0745	RESPONSE REGULATOR receiver
spnnt_RS11005	COG5002	protein histidine kinase activity
spnnt_RS11010	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
spnnt_RS11015	COG0573	inorganic phosphate transmembrane transporter activity
spnnt_RS11025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
spnnt_RS11030	COG0704	Plays a role in the regulation of phosphate uptake
spnnt_RS11050	COG1210	Utp--glucose-1-phosphate uridylyltransferase
spnnt_RS11060	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
spnnt_RS11075	COG0697	spore germination
spnnt_RS11080	COG4499	WXG100 protein secretion system (Wss), protein YukC
spnnt_RS11080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
spnnt_RS11090	COG2217	Heavy metal translocating P-type atpase
spnnt_RS11100	COG2226	methyltransferase
spnnt_RS11125	COG0058	SHG alpha-glucan phosphorylase activity
spnnt_RS11130	COG1640	4-alpha-glucanotransferase
spnnt_RS11135	COG2182	Extracellular solute-binding protein
spnnt_RS11140	COG1175	transmembrane transport
spnnt_RS11145	COG3833	ABC-type maltose transport systems, permease component
spnnt_RS11150	COG5521	maltodextrose utilization protein MalA
spnnt_RS11155	COG1609	Transcriptional regulator
spnnt_RS11165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
spnnt_RS11200	COG1476	TRANSCRIPTIONal
spnnt_RS11230	COG0124	histidyl-tRNA synthetase
spnnt_RS11245	COG2151	metal-sulfur cluster biosynthetic enzyme
spnnt_RS11260	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
spnnt_RS11265	COG3959	Transketolase, thiamine diphosphate binding domain
spnnt_RS11280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
spnnt_RS11300	COG0267	Belongs to the bacterial ribosomal protein bL33 family
spnnt_RS11350	COG0383	alpha-mannosidase activity
spnnt_RS11380	COG3250	beta-galactosidase activity
spnnt_RS11400	COG3443	Belongs to the bacterial solute-binding protein 9 family
spnnt_RS11400	COG0803	Belongs to the bacterial solute-binding protein 9 family
spnnt_RS11405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
spnnt_RS11410	COG1121	(ABC) transporter
spnnt_RS11415	COG1846	Transcriptional regulator
spnnt_RS11420	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
spnnt_RS11430	COG1696	Membrane protein involved in D-alanine export
spnnt_RS11445	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
spnnt_RS11450	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
spnnt_RS11470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
spnnt_RS11495	COG1755	Isoprenylcysteine carboxyl methyltransferase
spnnt_RS11500	COG5002	protein histidine kinase activity
spnnt_RS11505	COG0745	RESPONSE REGULATOR receiver
spnnt_RS11510	COG0542	response to heat
spnnt_RS11515	COG4463	regulation of RNA biosynthetic process
spnnt_RS11520	COG1116	anion transmembrane transporter activity
spnnt_RS11525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
spnnt_RS11530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
spnnt_RS11550	COG0305	Participates in initiation and elongation during chromosome replication
spnnt_RS11570	COG1040	competence protein
spnnt_RS11575	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
spnnt_RS11580	COG1739	Uncharacterized protein family UPF0029
spnnt_RS11600	COG3335	DDE superfamily endonuclease
spnnt_RS11620	COG3942	CHAP domain
spnnt_RS11635	COG1792	Involved in formation and maintenance of cell shape
spnnt_RS11640	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
spnnt_RS11645	COG1122	ATPase activity
spnnt_RS11650	COG1122	ATPase activity
spnnt_RS11655	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
spnnt_RS11665	COG0612	Peptidase, M16
spnnt_RS11670	COG0612	Peptidase, M16
spnnt_RS11675	COG2501	S4 domain
spnnt_RS11685	COG0517	IMP dehydrogenase activity
spnnt_RS11685	COG0516	GMP reductase activity
spnnt_RS11690	COG0180	Tryptophanyl-tRNA synthetase
spnnt_RS11695	COG0488	(ABC) transporter
spnnt_RS11710	COG2801	Transposase and inactivated derivatives
spnnt_RS11715	COG1511	domain protein
spnnt_RS11720	COG1511	domain protein
spnnt_RS11765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
spnnt_RS11770	COG1475	DNA binding
spnnt_RS11895	COG3250	beta-galactosidase activity
spnnt_RS11900	COG3583	domain protein