locus-tag	class	description
SPNOXC_RS00010	COG0592	DNA-directed DNA polymerase activity
SPNOXC_RS00020	COG0012	GTP binding
SPNOXC_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPNOXC_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPNOXC_RS00060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SPNOXC_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPNOXC_RS00220	COG0629	single-stranded DNA binding
SPNOXC_RS00240	COG0582	viral genome integration into host DNA
SPNOXC_RS00355	COG5263	repeat protein
SPNOXC_RS00355	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPNOXC_RS00375	COG0756	dUTP diphosphatase activity
SPNOXC_RS00385	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SPNOXC_RS00405	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPNOXC_RS00430	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPNOXC_RS00430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPNOXC_RS00435	COG1832	CoA-binding protein
SPNOXC_RS00445	COG2855	membrane
SPNOXC_RS00450	COG0436	Aminotransferase
SPNOXC_RS00485	COG2274	protein secretion by the type I secretion system
SPNOXC_RS00490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPNOXC_RS00500	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPNOXC_RS00505	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SPNOXC_RS00515	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPNOXC_RS00530	COG0151	Belongs to the GarS family
SPNOXC_RS00535	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPNOXC_RS00550	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPNOXC_RS00555	COG3583	domain protein
SPNOXC_RS00555	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPNOXC_RS00555	COG3064	Membrane
SPNOXC_RS00570	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPNOXC_RS00575	COG3715	PTS system
SPNOXC_RS00580	COG3716	PTS system mannose fructose sorbose family IID component
SPNOXC_RS00590	COG2222	sugar isomerase
SPNOXC_RS00600	COG2514	catechol 2,3-dioxygenase activity
SPNOXC_RS00605	COG1937	Protein conserved in bacteria
SPNOXC_RS00630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPNOXC_RS00635	COG0569	domain protein
SPNOXC_RS00665	COG5002	protein histidine kinase activity
SPNOXC_RS00685	COG4209	transmembrane transport
SPNOXC_RS00690	COG0395	ABC-type sugar transport system, permease component
SPNOXC_RS00695	COG1653	transport
SPNOXC_RS00725	COG1695	Transcriptional regulator
SPNOXC_RS00750	COG0546	phosphoglycolate phosphatase activity
SPNOXC_RS00755	COG1760	l-serine dehydratase
SPNOXC_RS00760	COG1760	l-serine dehydratase
SPNOXC_RS00800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPNOXC_RS00840	COG2274	protein secretion by the type I secretion system
SPNOXC_RS00930	COG0445	tRNA wobble uridine modification
SPNOXC_RS00960	COG1214	PFAM Peptidase M22, glycoprotease
SPNOXC_RS00970	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SPNOXC_RS01005	COG0438	transferase activity, transferring glycosyl groups
SPNOXC_RS01075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPNOXC_RS01080	COG1464	Belongs to the NlpA lipoprotein family
SPNOXC_RS01085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPNOXC_RS01090	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPNOXC_RS01110	COG2972	Histidine kinase
SPNOXC_RS01115	COG4753	response regulator
SPNOXC_RS01115	COG2207	Transcriptional regulator
SPNOXC_RS01125	COG1780	Probably involved in ribonucleotide reductase function
SPNOXC_RS01155	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPNOXC_RS01155	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPNOXC_RS01175	COG2818	Glycosylase
SPNOXC_RS01200	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPNOXC_RS01205	COG0006	proline dipeptidase activity
SPNOXC_RS01210	COG1393	Belongs to the ArsC family
SPNOXC_RS01235	COG0285	dihydrofolate synthase activity
SPNOXC_RS01245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPNOXC_RS01310	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPNOXC_RS01335	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SPNOXC_RS01375	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SPNOXC_RS01390	COG0201	protein transport
SPNOXC_RS01400	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SPNOXC_RS01405	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SPNOXC_RS01415	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SPNOXC_RS01420	COG0202	RNA polymerase activity
SPNOXC_RS01430	COG3830	Belongs to the UPF0237 family
SPNOXC_RS01450	COG1178	ABC-type Fe3 transport system permease component
SPNOXC_RS01455	COG3842	ATPase activity
SPNOXC_RS01475	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPNOXC_RS01480	COG1349	DNA-binding transcription factor activity
SPNOXC_RS01490	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPNOXC_RS01495	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPNOXC_RS01500	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPNOXC_RS01505	COG1882	Formate acetyltransferase
SPNOXC_RS01555	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPNOXC_RS01560	COG4589	Belongs to the CDS family
SPNOXC_RS01565	COG0750	zinc metalloprotease
SPNOXC_RS01575	COG2723	6-phospho-beta-galactosidase activity
SPNOXC_RS01580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPNOXC_RS01590	COG1523	belongs to the glycosyl hydrolase 13 family
SPNOXC_RS01610	COG2176	DNA-directed DNA polymerase activity
SPNOXC_RS01630	COG2309	aminopeptidase activity
SPNOXC_RS01635	COG2261	transglycosylase associated protein
SPNOXC_RS01640	COG1187	pseudouridine synthase activity
SPNOXC_RS01650	COG3579	cysteine-type endopeptidase activity
SPNOXC_RS01655	COG3716	PTS system mannose fructose sorbose family IID component
SPNOXC_RS01660	COG3715	PTS system
SPNOXC_RS01670	COG1064	alcohol dehydrogenase
SPNOXC_RS01675	COG0561	phosphatase activity
SPNOXC_RS01680	COG2252	PERMEase
SPNOXC_RS01690	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SPNOXC_RS01695	COG0285	dihydrofolate synthase activity
SPNOXC_RS01700	COG0302	gtp cyclohydrolase
SPNOXC_RS01705	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SPNOXC_RS01705	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPNOXC_RS01715	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPNOXC_RS01730	COG2723	6-phospho-beta-galactosidase activity
SPNOXC_RS01745	COG3711	transcriptional antiterminator
SPNOXC_RS01745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPNOXC_RS01760	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPNOXC_RS01775	COG0386	Belongs to the glutathione peroxidase family
SPNOXC_RS01790	COG0800	Aldolase
SPNOXC_RS01805	COG1028	Short-chain dehydrogenase reductase Sdr
SPNOXC_RS01815	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SPNOXC_RS01820	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPNOXC_RS01825	COG3715	PTS system
SPNOXC_RS01830	COG3716	PTS system mannose fructose sorbose family IID component
SPNOXC_RS01845	COG1609	Transcriptional regulator
SPNOXC_RS01875	COG4839	cell division protein FtsL
SPNOXC_RS01880	COG0768	penicillin binding
SPNOXC_RS01905	COG0366	Alpha amylase catalytic
SPNOXC_RS01910	COG4166	transmembrane transport
SPNOXC_RS01965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPNOXC_RS01970	COG4166	transmembrane transport
SPNOXC_RS01975	COG0366	Alpha amylase catalytic
SPNOXC_RS01980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPNOXC_RS02005	COG0116	Belongs to the methyltransferase superfamily
SPNOXC_RS02015	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SPNOXC_RS02020	COG0745	RESPONSE REGULATOR receiver
SPNOXC_RS02075	COG4585	Histidine kinase
SPNOXC_RS02080	COG2197	response regulator
SPNOXC_RS02110	COG0582	viral genome integration into host DNA
SPNOXC_RS02120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPNOXC_RS02125	COG0681	Belongs to the peptidase S26 family
SPNOXC_RS02150	COG1115	amino acid carrier protein
SPNOXC_RS02165	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SPNOXC_RS02175	COG0527	aspartate kinase activity
SPNOXC_RS02180	COG1024	Enoyl-CoA hydratase
SPNOXC_RS02185	COG1846	Transcriptional regulator
SPNOXC_RS02195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPNOXC_RS02205	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPNOXC_RS02210	COG1028	Short-chain dehydrogenase reductase Sdr
SPNOXC_RS02215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPNOXC_RS02230	COG0439	Biotin carboxylase
SPNOXC_RS02235	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPNOXC_RS02305	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SPNOXC_RS02315	COG1461	Dihydroxyacetone kinase
SPNOXC_RS02320	COG0028	Belongs to the TPP enzyme family
SPNOXC_RS02325	COG0440	acetolactate synthase activity
SPNOXC_RS02345	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SPNOXC_RS02360	COG0765	amino acid transport
SPNOXC_RS02390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPNOXC_RS02395	COG1882	Formate acetyltransferase
SPNOXC_RS02430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPNOXC_RS02435	COG0569	domain protein
SPNOXC_RS02455	COG1122	ATPase activity
SPNOXC_RS02470	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPNOXC_RS02475	COG0671	phosphoesterase, PA-phosphatase related
SPNOXC_RS02485	COG1247	-acetyltransferase
SPNOXC_RS02500	COG0504	CTP synthase activity
SPNOXC_RS02505	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPNOXC_RS02525	COG0789	Transcriptional regulator
SPNOXC_RS02530	COG0174	glutamine synthetase
SPNOXC_RS02540	COG0732	type I restriction modification DNA specificity domain
SPNOXC_RS02550	COG4974	Belongs to the 'phage' integrase family
SPNOXC_RS02600	COG0484	heat shock protein binding
SPNOXC_RS02615	COG0537	adenosine 5'-monophosphoramidase activity
SPNOXC_RS02620	COG1131	(ABC) transporter
SPNOXC_RS02625	COG4473	ABC transporter
SPNOXC_RS02645	COG3290	protein histidine kinase activity
SPNOXC_RS02655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPNOXC_RS02665	COG2274	protein secretion by the type I secretion system
SPNOXC_RS02705	COG1266	CAAX protease self-immunity
SPNOXC_RS02725	COG0195	Participates in both transcription termination and antitermination
SPNOXC_RS02730	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPNOXC_RS02795	COG0519	Catalyzes the synthesis of GMP from XMP
SPNOXC_RS02805	COG0525	valine-tRNA ligase activity
SPNOXC_RS02820	COG2801	Transposase and inactivated derivatives
SPNOXC_RS02825	COG2801	Transposase and inactivated derivatives
SPNOXC_RS02845	COG3711	transcriptional antiterminator
SPNOXC_RS02850	COG2190	(PTS) system
SPNOXC_RS02850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPNOXC_RS02850	COG1263	PTS System
SPNOXC_RS02870	COG0456	acetyltransferase
SPNOXC_RS02875	COG0072	phenylalanine-tRNA ligase activity
SPNOXC_RS02875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPNOXC_RS02895	COG3620	sequence-specific DNA binding
SPNOXC_RS02900	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SPNOXC_RS02915	COG1045	serine acetyltransferase
SPNOXC_RS02925	COG0215	cysteine-tRNA ligase activity
SPNOXC_RS02930	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPNOXC_RS02950	COG0577	efflux transmembrane transporter activity
SPNOXC_RS02955	COG1136	(ABC) transporter
SPNOXC_RS02960	COG0577	efflux transmembrane transporter activity
SPNOXC_RS02965	COG0745	RESPONSE REGULATOR receiver
SPNOXC_RS02970	COG5002	protein histidine kinase activity
SPNOXC_RS02975	COG0191	fructose-bisphosphate aldolase activity
SPNOXC_RS02985	COG0765	amino acid transport
SPNOXC_RS02990	COG0765	amino acid transport
SPNOXC_RS02995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPNOXC_RS03005	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPNOXC_RS03005	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPNOXC_RS03035	COG0322	excinuclease ABC activity
SPNOXC_RS03045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPNOXC_RS03060	COG1573	uracil-dna glycosylase
SPNOXC_RS03070	COG1114	Component of the transport system for branched-chain amino acids
SPNOXC_RS03075	COG1363	Peptidase, m42
SPNOXC_RS03120	COG4555	ABC transporter
SPNOXC_RS03155	COG1404	Belongs to the peptidase S8 family
SPNOXC_RS03170	COG3775	system Galactitol-specific IIC component
SPNOXC_RS03180	COG3250	beta-galactosidase activity
SPNOXC_RS03200	COG1242	4 iron, 4 sulfur cluster binding
SPNOXC_RS03205	COG1242	4 iron, 4 sulfur cluster binding
SPNOXC_RS03210	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPNOXC_RS03230	COG0785	Cytochrome C biogenesis protein
SPNOXC_RS03235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPNOXC_RS03240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPNOXC_RS03240	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPNOXC_RS03245	COG4753	response regulator
SPNOXC_RS03245	COG2207	Transcriptional regulator
SPNOXC_RS03250	COG2972	Histidine kinase
SPNOXC_RS03260	COG3064	Membrane
SPNOXC_RS03265	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPNOXC_RS03280	COG1940	carbohydrate kinase activity
SPNOXC_RS03295	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SPNOXC_RS03300	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPNOXC_RS03305	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPNOXC_RS03315	COG0300	oxidoreductase activity
SPNOXC_RS03330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPNOXC_RS03340	COG1187	pseudouridine synthase activity
SPNOXC_RS03345	COG1217	gtp-binding protein TYPA
SPNOXC_RS03365	COG1136	(ABC) transporter
SPNOXC_RS03380	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SPNOXC_RS03390	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SPNOXC_RS03415	COG1131	(ABC) transporter
SPNOXC_RS03420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPNOXC_RS03425	COG1126	abc transporter atp-binding protein
SPNOXC_RS03430	COG1129	ABC transporter
SPNOXC_RS03435	COG4215	(ABC) transporter
SPNOXC_RS03440	COG4597	amino acid ABC transporter
SPNOXC_RS03445	COG1304	FMN binding
SPNOXC_RS03455	COG1304	FMN binding
SPNOXC_RS03470	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SPNOXC_RS03475	COG0352	thiamine-phosphate diphosphorylase activity
SPNOXC_RS03485	COG4172	Belongs to the ABC transporter superfamily
SPNOXC_RS03495	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SPNOXC_RS03510	COG0352	thiamine-phosphate diphosphorylase activity
SPNOXC_RS03530	COG2217	Heavy metal translocating P-type atpase
SPNOXC_RS03535	COG0028	Belongs to the TPP enzyme family
SPNOXC_RS03555	COG2723	6-phospho-beta-galactosidase activity
SPNOXC_RS03560	COG1482	cell wall glycoprotein biosynthetic process
SPNOXC_RS03565	COG0733	neurotransmitter:sodium symporter activity
SPNOXC_RS03575	COG0789	Transcriptional regulator
SPNOXC_RS03585	COG2081	HI0933 family
SPNOXC_RS03590	COG1307	EDD domain protein, DegV family
SPNOXC_RS03600	COG2131	deaminase
SPNOXC_RS03605	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SPNOXC_RS03645	COG0517	IMP dehydrogenase activity
SPNOXC_RS03645	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPNOXC_RS03645	COG0617	tRNA 3'-terminal CCA addition
SPNOXC_RS03650	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SPNOXC_RS03655	COG2884	Cell division ATP-binding protein ftsE
SPNOXC_RS03660	COG2177	Part of the ABC transporter FtsEX involved in
SPNOXC_RS03665	COG1263	PTS System
SPNOXC_RS03665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPNOXC_RS03665	COG2190	(PTS) system
SPNOXC_RS03675	COG0513	Belongs to the DEAD box helicase family
SPNOXC_RS03685	COG0167	dihydroorotate dehydrogenase activity
SPNOXC_RS03695	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SPNOXC_RS03700	COG4470	Protein conserved in bacteria
SPNOXC_RS03715	COG0488	(ABC) transporter
SPNOXC_RS03720	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SPNOXC_RS03740	COG1837	Belongs to the UPF0109 family
SPNOXC_RS03760	COG1328	CTP reductase activity
SPNOXC_RS03760	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPNOXC_RS03770	COG4443	Transcriptional Coactivator p15 (PC4)
SPNOXC_RS03780	COG1268	BioY protein
SPNOXC_RS03785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPNOXC_RS03790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPNOXC_RS03795	COG1136	(ABC) transporter
SPNOXC_RS03800	COG0577	efflux transmembrane transporter activity
SPNOXC_RS03805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPNOXC_RS03805	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPNOXC_RS03825	COG4989	oxidoreductase activity
SPNOXC_RS03835	COG1028	Short-chain dehydrogenase reductase Sdr
SPNOXC_RS03865	COG0745	RESPONSE REGULATOR receiver
SPNOXC_RS03870	COG5002	protein histidine kinase activity
SPNOXC_RS03890	COG0772	Belongs to the SEDS family
SPNOXC_RS03895	COG0693	protein deglycase activity
SPNOXC_RS03905	COG0187	DNA topoisomerase II activity
SPNOXC_RS03925	COG0494	nUDIX hydrolase
SPNOXC_RS03940	COG0542	response to heat
SPNOXC_RS03945	COG4703	Protein of unknown function (DUF1797)
SPNOXC_RS03950	COG0765	amino acid transport
SPNOXC_RS03960	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPNOXC_RS03965	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SPNOXC_RS03985	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SPNOXC_RS04030	COG2813	Specifically methylates the guanine in position
SPNOXC_RS04035	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SPNOXC_RS04045	COG0295	cytidine deaminase activity
SPNOXC_RS04050	COG1744	ABC transporter substrate-binding protein PnrA-like
SPNOXC_RS04055	COG3845	ABC transporter
SPNOXC_RS04060	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPNOXC_RS04065	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPNOXC_RS04080	COG2801	Transposase and inactivated derivatives
SPNOXC_RS04085	COG2801	Transposase and inactivated derivatives
SPNOXC_RS04100	COG0187	DNA topoisomerase II activity
SPNOXC_RS04110	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPNOXC_RS04115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPNOXC_RS04120	COG4166	transmembrane transport
SPNOXC_RS04155	COG0539	negative regulation of cytoplasmic translation
SPNOXC_RS04175	COG1956	GAF domain-containing protein
SPNOXC_RS04180	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPNOXC_RS04195	COG0719	Fe-S assembly protein
SPNOXC_RS04200	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPNOXC_RS04210	COG0719	Fe-S assembly protein
SPNOXC_RS04220	COG1686	Belongs to the peptidase S11 family
SPNOXC_RS04225	COG0628	permease
SPNOXC_RS04235	COG1349	DNA-binding transcription factor activity
SPNOXC_RS04240	COG1105	Belongs to the carbohydrate kinase PfkB family
SPNOXC_RS04245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPNOXC_RS04245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPNOXC_RS04245	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPNOXC_RS04250	COG0697	spore germination
SPNOXC_RS04250	COG1674	ftsk spoiiie
SPNOXC_RS04260	COG1104	cysteine desulfurase activity
SPNOXC_RS04330	COG1438	arginine binding
SPNOXC_RS04350	COG0469	pyruvate kinase activity
SPNOXC_RS04355	COG0582	viral genome integration into host DNA
SPNOXC_RS04390	COG3689	TIGRFAM TIGR03943 family protein
SPNOXC_RS04395	COG0701	Predicted permease
SPNOXC_RS04405	COG2183	response to ionizing radiation
SPNOXC_RS04425	COG1136	(ABC) transporter
SPNOXC_RS04430	COG0577	efflux transmembrane transporter activity
SPNOXC_RS04445	COG1982	Orn Lys Arg decarboxylase major
SPNOXC_RS04465	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SPNOXC_RS04485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPNOXC_RS04490	COG0561	phosphatase activity
SPNOXC_RS04510	COG0583	DNA-binding transcription factor activity
SPNOXC_RS04515	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPNOXC_RS04520	COG0564	pseudouridine synthase activity
SPNOXC_RS04525	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPNOXC_RS04540	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPNOXC_RS04550	COG0470	DNA polymerase III
SPNOXC_RS04595	COG0528	UMP kinase activity
SPNOXC_RS04605	COG2996	Protein conserved in bacteria
SPNOXC_RS04615	COG1702	phosphate starvation-inducible protein PhoH
SPNOXC_RS04630	COG0686	Belongs to the AlaDH PNT family
SPNOXC_RS04635	COG0686	Belongs to the AlaDH PNT family
SPNOXC_RS04640	COG0686	Belongs to the AlaDH PNT family
SPNOXC_RS04645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPNOXC_RS04650	COG1596	polysaccharide export
SPNOXC_RS04650	COG1555	photosystem II stabilization
SPNOXC_RS04655	COG0658	competence protein
SPNOXC_RS04655	COG2333	competence protein COMEC
SPNOXC_RS04665	COG1131	(ABC) transporter
SPNOXC_RS04695	COG0543	2 iron, 2 sulfur cluster binding
SPNOXC_RS04700	COG0167	dihydroorotate dehydrogenase activity
SPNOXC_RS04705	COG5263	repeat protein
SPNOXC_RS04705	COG4193	domain, Protein
SPNOXC_RS04710	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPNOXC_RS04720	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPNOXC_RS04730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPNOXC_RS04735	COG0237	dephospho-CoA kinase activity
SPNOXC_RS04740	COG2814	Major facilitator Superfamily
SPNOXC_RS04745	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPNOXC_RS04755	COG0557	exoribonuclease II activity
SPNOXC_RS04765	COG3615	Tellurite resistance protein tehB
SPNOXC_RS04765	COG0500	methyltransferase
SPNOXC_RS04780	COG4122	O-methyltransferase activity
SPNOXC_RS04790	COG2801	Transposase and inactivated derivatives
SPNOXC_RS04805	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SPNOXC_RS04825	COG0494	nUDIX hydrolase
SPNOXC_RS04835	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPNOXC_RS04845	COG2176	DNA-directed DNA polymerase activity
SPNOXC_RS04850	COG0584	glycerophosphoryl diester phosphodiesterase
SPNOXC_RS04870	COG0785	Cytochrome C biogenesis protein
SPNOXC_RS04875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPNOXC_RS04880	COG0531	amino acid
SPNOXC_RS04885	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPNOXC_RS04885	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPNOXC_RS04930	COG1970	mechanosensitive ion channel activity
SPNOXC_RS04940	COG4708	membrane
SPNOXC_RS04950	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPNOXC_RS04960	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SPNOXC_RS04965	COG1942	4-Oxalocrotonate Tautomerase
SPNOXC_RS04970	COG1435	thymidine kinase activity
SPNOXC_RS04975	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SPNOXC_RS04980	COG2890	protein-(glutamine-N5) methyltransferase activity
SPNOXC_RS05005	COG0741	lytic transglycosylase activity
SPNOXC_RS05015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPNOXC_RS05035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPNOXC_RS05040	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPNOXC_RS05090	COG1597	lipid kinase activity
SPNOXC_RS05095	COG0366	Alpha amylase catalytic
SPNOXC_RS05110	COG1396	sequence-specific DNA binding
SPNOXC_RS05115	COG0542	response to heat
SPNOXC_RS05120	COG0613	PHP domain protein
SPNOXC_RS05145	COG1181	Belongs to the D-alanine--D-alanine ligase family
SPNOXC_RS05150	COG0148	phosphopyruvate hydratase activity
SPNOXC_RS05155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPNOXC_RS05160	COG3959	Transketolase, thiamine diphosphate binding domain
SPNOXC_RS05165	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPNOXC_RS05170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SPNOXC_RS05180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SPNOXC_RS05195	COG0028	Belongs to the TPP enzyme family
SPNOXC_RS05195	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
SPNOXC_RS05210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPNOXC_RS05220	COG4555	ABC transporter
SPNOXC_RS05235	COG2723	6-phospho-beta-galactosidase activity
SPNOXC_RS05240	COG1396	sequence-specific DNA binding
SPNOXC_RS05265	COG0772	Belongs to the SEDS family
SPNOXC_RS05270	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SPNOXC_RS05285	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPNOXC_RS05290	COG0358	DNA primase activity
SPNOXC_RS05295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPNOXC_RS05300	COG2151	metal-sulfur cluster biosynthetic enzyme
SPNOXC_RS05305	COG0438	transferase activity, transferring glycosyl groups
SPNOXC_RS05310	COG0438	transferase activity, transferring glycosyl groups
SPNOXC_RS05335	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPNOXC_RS05345	COG4109	DRTGG domain
SPNOXC_RS05350	COG0024	Methionine aminopeptidase
SPNOXC_RS05365	COG0210	DNA helicase
SPNOXC_RS05375	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPNOXC_RS05395	COG1104	cysteine desulfurase activity
SPNOXC_RS05400	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPNOXC_RS05410	COG2357	RelA SpoT domain protein
SPNOXC_RS05420	COG0564	pseudouridine synthase activity
SPNOXC_RS05425	COG0280	phosphate acetyltransferase
SPNOXC_RS05465	COG0196	riboflavin kinase activity
SPNOXC_RS05470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPNOXC_RS05475	COG1307	EDD domain protein, DegV family
SPNOXC_RS05485	COG0488	(ABC) transporter
SPNOXC_RS05505	COG1523	belongs to the glycosyl hydrolase 13 family
SPNOXC_RS05515	COG1012	belongs to the aldehyde dehydrogenase family
SPNOXC_RS05520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SPNOXC_RS05530	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SPNOXC_RS05540	COG0560	Phosphoserine phosphatase
SPNOXC_RS05545	COG0560	Phosphoserine phosphatase
SPNOXC_RS05565	COG0582	viral genome integration into host DNA
SPNOXC_RS05590	COG1074	ATP-dependent DNA helicase activity
SPNOXC_RS05610	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPNOXC_RS05615	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SPNOXC_RS05630	COG0095	Lipoate-protein ligase
SPNOXC_RS05635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPNOXC_RS05640	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPNOXC_RS05645	COG0022	dehydrogenase e1 component
SPNOXC_RS05650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPNOXC_RS05655	COG0534	Mate efflux family protein
SPNOXC_RS05665	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPNOXC_RS05670	COG1051	belongs to the nudix hydrolase family
SPNOXC_RS05685	COG1011	Hydrolase
SPNOXC_RS05690	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SPNOXC_RS05705	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPNOXC_RS05710	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPNOXC_RS05715	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPNOXC_RS05720	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPNOXC_RS05750	COG3711	transcriptional antiterminator
SPNOXC_RS05755	COG3684	Belongs to the aldolase LacD family
SPNOXC_RS05810	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SPNOXC_RS05815	COG0497	DNA recombination
SPNOXC_RS05820	COG1438	arginine binding
SPNOXC_RS05825	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPNOXC_RS05860	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SPNOXC_RS05880	COG3764	Sortase (surface protein transpeptidase)
SPNOXC_RS05885	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPNOXC_RS05895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SPNOXC_RS05910	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPNOXC_RS05915	COG5002	protein histidine kinase activity
SPNOXC_RS05920	COG0745	RESPONSE REGULATOR receiver
SPNOXC_RS05925	COG1194	a g-specific adenine glycosylase
SPNOXC_RS05940	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPNOXC_RS05945	COG4684	Psort location CytoplasmicMembrane, score
SPNOXC_RS05955	COG1827	regulation of RNA biosynthetic process
SPNOXC_RS05985	COG0765	amino acid transport
SPNOXC_RS05990	COG1126	abc transporter atp-binding protein
SPNOXC_RS05995	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPNOXC_RS06000	COG0552	protein localization to endoplasmic reticulum
SPNOXC_RS06005	COG0561	phosphatase activity
SPNOXC_RS06010	COG0561	phosphatase activity
SPNOXC_RS06015	COG1196	nuclear chromosome segregation
SPNOXC_RS06040	COG1401	restriction endodeoxyribonuclease activity
SPNOXC_RS06055	COG0066	3-isopropylmalate dehydratase activity
SPNOXC_RS06085	COG3142	Participates in the control of copper homeostasis
SPNOXC_RS06090	COG2832	Protein of unknown function (DUF454)
SPNOXC_RS06095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPNOXC_RS06105	COG0758	DNA mediated transformation
SPNOXC_RS06110	COG4750	Nucleotidyl transferase
SPNOXC_RS06125	COG1063	alcohol dehydrogenase
SPNOXC_RS06140	COG3475	LICD family
SPNOXC_RS06145	COG3475	LICD family
SPNOXC_RS06155	COG0505	Belongs to the CarA family
SPNOXC_RS06170	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPNOXC_RS06185	COG0488	(ABC) transporter
SPNOXC_RS06195	COG1704	LemA family
SPNOXC_RS06210	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPNOXC_RS06225	COG1078	dGTPase activity
SPNOXC_RS06245	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPNOXC_RS06250	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPNOXC_RS06255	COG1605	Chorismate mutase
SPNOXC_RS06255	COG0077	Prephenate dehydratase
SPNOXC_RS06260	COG0716	FMN binding
SPNOXC_RS06265	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPNOXC_RS06285	COG3335	DDE superfamily endonuclease
SPNOXC_RS06295	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPNOXC_RS06325	COG3335	DDE superfamily endonuclease
SPNOXC_RS06355	COG0577	efflux transmembrane transporter activity
SPNOXC_RS06355	COG1136	(ABC) transporter
SPNOXC_RS06365	COG0515	serine threonine protein kinase
SPNOXC_RS06405	COG0402	S-adenosylhomocysteine deaminase activity
SPNOXC_RS06415	COG1132	(ABC) transporter
SPNOXC_RS06420	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPNOXC_RS06420	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPNOXC_RS06455	COG1215	transferase activity, transferring glycosyl groups
SPNOXC_RS06465	COG3475	LICD family
SPNOXC_RS06475	COG0077	Prephenate dehydratase
SPNOXC_RS06480	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SPNOXC_RS06495	COG0287	Prephenate dehydrogenase
SPNOXC_RS06520	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPNOXC_RS06530	COG1131	(ABC) transporter
SPNOXC_RS06570	COG3842	ATPase activity
SPNOXC_RS06585	COG3527	Alpha-acetolactate decarboxylase
SPNOXC_RS06590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPNOXC_RS06595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPNOXC_RS06600	COG0704	Plays a role in the regulation of phosphate uptake
SPNOXC_RS06605	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPNOXC_RS06610	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPNOXC_RS06615	COG0581	inorganic phosphate transmembrane transporter activity
SPNOXC_RS06620	COG0573	inorganic phosphate transmembrane transporter activity
SPNOXC_RS06625	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPNOXC_RS06630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPNOXC_RS06630	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPNOXC_RS06635	COG0483	inositol monophosphate 1-phosphatase activity
SPNOXC_RS06645	COG1393	Belongs to the ArsC family
SPNOXC_RS06655	COG0647	UMP catabolic process
SPNOXC_RS06665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPNOXC_RS06700	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SPNOXC_RS06710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPNOXC_RS06720	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPNOXC_RS06755	COG0826	peptidase U32
SPNOXC_RS06780	COG1132	(ABC) transporter
SPNOXC_RS06785	COG1132	(ABC) transporter
SPNOXC_RS06800	COG1129	ABC transporter
SPNOXC_RS06810	COG4372	Transposase
SPNOXC_RS06845	COG2188	Transcriptional regulator
SPNOXC_RS06850	COG0697	spore germination
SPNOXC_RS06855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPNOXC_RS06870	COG0561	phosphatase activity
SPNOXC_RS06900	COG0492	ferredoxin-NADP+ reductase activity
SPNOXC_RS06910	COG1126	abc transporter atp-binding protein
SPNOXC_RS06920	COG1393	Belongs to the ArsC family
SPNOXC_RS06925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SPNOXC_RS06940	COG1272	protein, Hemolysin III
SPNOXC_RS06970	COG1053	succinate dehydrogenase
SPNOXC_RS06970	COG3976	FMN-binding domain protein
SPNOXC_RS06970	COG0431	NADPH-dependent FMN reductase
SPNOXC_RS06980	COG0751	glycine-tRNA ligase activity
SPNOXC_RS06995	COG0656	L-ascorbic acid biosynthetic process
SPNOXC_RS07000	COG0726	polysaccharide deacetylase
SPNOXC_RS07020	COG3335	DDE superfamily endonuclease
SPNOXC_RS07035	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPNOXC_RS07070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPNOXC_RS07080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPNOXC_RS07085	COG1126	abc transporter atp-binding protein
SPNOXC_RS07100	COG0628	permease
SPNOXC_RS07105	COG2706	6-phosphogluconolactonase activity
SPNOXC_RS07120	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SPNOXC_RS07175	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPNOXC_RS07200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPNOXC_RS07205	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SPNOXC_RS07210	COG0626	cystathionine gamma-synthase activity
SPNOXC_RS07215	COG1132	(ABC) transporter
SPNOXC_RS07220	COG1132	(ABC) transporter
SPNOXC_RS07230	COG4166	transmembrane transport
SPNOXC_RS07235	COG2244	polysaccharide biosynthetic process
SPNOXC_RS07240	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPNOXC_RS07265	COG2827	Endonuclease containing a URI domain
SPNOXC_RS07270	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPNOXC_RS07275	COG1098	S1 RNA binding domain
SPNOXC_RS07285	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPNOXC_RS07290	COG0629	single-stranded DNA binding
SPNOXC_RS07300	COG0017	Asparaginyl-tRNA synthetase
SPNOXC_RS07310	COG0436	Aminotransferase
SPNOXC_RS07345	COG0242	peptide deformylase activity
SPNOXC_RS07350	COG0625	glutathione transferase activity
SPNOXC_RS07360	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPNOXC_RS07365	COG0488	(ABC) transporter
SPNOXC_RS07370	COG0617	tRNA 3'-terminal CCA addition
SPNOXC_RS07380	COG1307	EDD domain protein, DegV family
SPNOXC_RS07400	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPNOXC_RS07420	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SPNOXC_RS07430	COG0251	oxidation-reduction process
SPNOXC_RS07450	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPNOXC_RS07470	COG3935	DnaD domain protein
SPNOXC_RS07485	COG2226	methyltransferase
SPNOXC_RS07495	COG3842	ATPase activity
SPNOXC_RS07505	COG1335	isochorismatase
SPNOXC_RS07515	COG0513	Belongs to the DEAD box helicase family
SPNOXC_RS07520	COG2223	nitrite transmembrane transporter activity
SPNOXC_RS07525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPNOXC_RS07530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPNOXC_RS07535	COG3442	glutamine amidotransferase
SPNOXC_RS07540	COG0006	proline dipeptidase activity
SPNOXC_RS07545	COG2801	Transposase and inactivated derivatives
SPNOXC_RS07560	COG4720	Psort location CytoplasmicMembrane, score
SPNOXC_RS07565	COG0351	phosphomethylpyrimidine kinase
SPNOXC_RS07590	COG2824	Alkylphosphonate utilization operon protein PhnA
SPNOXC_RS07610	COG0463	Glycosyl transferase, family 2
SPNOXC_RS07615	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPNOXC_RS07625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPNOXC_RS07630	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SPNOXC_RS07635	COG2384	SAM-dependent methyltransferase
SPNOXC_RS07650	COG2801	Transposase and inactivated derivatives
SPNOXC_RS07655	COG2801	Transposase and inactivated derivatives
SPNOXC_RS07670	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SPNOXC_RS07675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SPNOXC_RS07680	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPNOXC_RS07680	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
SPNOXC_RS07680	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPNOXC_RS07685	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPNOXC_RS07705	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SPNOXC_RS07710	COG0204	Acyl-transferase
SPNOXC_RS07725	COG2910	NAD(P)H-binding
SPNOXC_RS07745	COG5002	protein histidine kinase activity
SPNOXC_RS07750	COG0745	RESPONSE REGULATOR receiver
SPNOXC_RS07765	COG1959	2 iron, 2 sulfur cluster binding
SPNOXC_RS07825	COG3590	peptidase
SPNOXC_RS07840	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPNOXC_RS07845	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SPNOXC_RS07860	COG0577	efflux transmembrane transporter activity
SPNOXC_RS07860	COG1136	(ABC) transporter
SPNOXC_RS07905	COG3599	regulation of cell shape
SPNOXC_RS07925	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPNOXC_RS07945	COG1051	belongs to the nudix hydrolase family
SPNOXC_RS07950	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPNOXC_RS07965	COG0768	penicillin binding
SPNOXC_RS07980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPNOXC_RS07995	COG2731	YhcH YjgK YiaL family protein
SPNOXC_RS08000	COG0395	ABC-type sugar transport system, permease component
SPNOXC_RS08005	COG1175	transmembrane transport
SPNOXC_RS08015	COG2190	(PTS) system
SPNOXC_RS08015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPNOXC_RS08015	COG1263	PTS System
SPNOXC_RS08025	COG0673	inositol 2-dehydrogenase activity
SPNOXC_RS08030	COG4409	exo-alpha-(2->6)-sialidase activity
SPNOXC_RS08040	COG1175	transmembrane transport
SPNOXC_RS08045	COG1653	transport
SPNOXC_RS08065	COG3458	cephalosporin-C deacetylase activity
SPNOXC_RS08070	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPNOXC_RS08085	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPNOXC_RS08090	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPNOXC_RS08095	COG0653	protein targeting
SPNOXC_RS08105	COG1131	(ABC) transporter
SPNOXC_RS08135	COG0778	Nitroreductase
SPNOXC_RS08140	COG1484	DNA-dependent DNA replication
SPNOXC_RS08155	COG1725	Transcriptional regulator
SPNOXC_RS08160	COG1131	(ABC) transporter
SPNOXC_RS08170	COG1668	transmembrane transport
SPNOXC_RS08175	COG4152	abc transporter atp-binding protein
SPNOXC_RS08190	COG1940	carbohydrate kinase activity
SPNOXC_RS08195	COG1263	PTS System
SPNOXC_RS08195	COG2190	(PTS) system
SPNOXC_RS08195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPNOXC_RS08205	COG1621	beta-fructofuranosidase activity
SPNOXC_RS08210	COG1609	Transcriptional regulator
SPNOXC_RS08220	COG3425	synthase
SPNOXC_RS08250	COG0515	serine threonine protein kinase
SPNOXC_RS08250	COG2815	serine threonine protein kinase
SPNOXC_RS08255	COG0631	protein serine/threonine phosphatase activity
SPNOXC_RS08260	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPNOXC_RS08260	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPNOXC_RS08270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPNOXC_RS08280	COG0194	GDP metabolic process
SPNOXC_RS08295	COG1323	Belongs to the UPF0348 family
SPNOXC_RS08300	COG2226	methyltransferase
SPNOXC_RS08305	COG0799	negative regulation of ribosome biogenesis
SPNOXC_RS08315	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPNOXC_RS08320	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SPNOXC_RS08325	COG1534	Rna-binding protein
SPNOXC_RS08330	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPNOXC_RS08345	COG0668	transmembrane transport
SPNOXC_RS08370	COG3118	belongs to the thioredoxin family
SPNOXC_RS08375	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SPNOXC_RS08385	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPNOXC_RS08400	COG1164	Oligoendopeptidase f
SPNOXC_RS08405	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPNOXC_RS08415	COG1051	belongs to the nudix hydrolase family
SPNOXC_RS08450	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPNOXC_RS08505	COG1621	beta-fructofuranosidase activity
SPNOXC_RS08510	COG1653	transport
SPNOXC_RS08515	COG0395	ABC-type sugar transport system, permease component
SPNOXC_RS08520	COG4209	transmembrane transport
SPNOXC_RS08530	COG3711	transcriptional antiterminator
SPNOXC_RS08555	COG3237	CsbD-like
SPNOXC_RS08575	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPNOXC_RS08585	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPNOXC_RS08590	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPNOXC_RS08595	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPNOXC_RS08605	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPNOXC_RS08610	COG1846	Transcriptional regulator
SPNOXC_RS08610	COG1940	carbohydrate kinase activity
SPNOXC_RS08620	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SPNOXC_RS08660	COG0512	Glutamine amidotransferase of anthranilate synthase
SPNOXC_RS08665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPNOXC_RS08690	COG1285	pathogenesis
SPNOXC_RS08695	COG1178	ABC-type Fe3 transport system permease component
SPNOXC_RS08720	COG5434	Belongs to the glycosyl hydrolase 28 family
SPNOXC_RS08735	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SPNOXC_RS08740	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPNOXC_RS08745	COG1132	(ABC) transporter
SPNOXC_RS08750	COG1132	(ABC) transporter
SPNOXC_RS08775	COG0708	Exodeoxyribonuclease III
SPNOXC_RS08795	COG2233	PERMEase
SPNOXC_RS08820	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPNOXC_RS08825	COG1609	Transcriptional regulator
SPNOXC_RS08830	COG1063	alcohol dehydrogenase
SPNOXC_RS08835	COG0789	Transcriptional regulator
SPNOXC_RS08840	COG1230	cation diffusion facilitator family transporter
SPNOXC_RS08850	COG3201	nicotinamide mononucleotide transporter
SPNOXC_RS08855	COG1174	glycine betaine transport
SPNOXC_RS08880	COG1363	Peptidase, m42
SPNOXC_RS08885	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPNOXC_RS08895	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPNOXC_RS08900	COG4605	iron ion homeostasis
SPNOXC_RS08905	COG4604	ABC transporter, ATP-binding protein
SPNOXC_RS08910	COG4607	ABC-type enterochelin transport system periplasmic component
SPNOXC_RS08920	COG1187	pseudouridine synthase activity
SPNOXC_RS08950	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SPNOXC_RS08965	COG0366	Alpha amylase catalytic
SPNOXC_RS08970	COG1263	PTS System
SPNOXC_RS08970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPNOXC_RS08975	COG2188	Transcriptional regulator
SPNOXC_RS08995	COG4608	Belongs to the ABC transporter superfamily
SPNOXC_RS09000	COG0444	Belongs to the ABC transporter superfamily
SPNOXC_RS09005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPNOXC_RS09010	COG0601	transmembrane transport
SPNOXC_RS09015	COG4166	transmembrane transport
SPNOXC_RS09025	COG0366	Alpha amylase catalytic
SPNOXC_RS09035	COG0395	ABC-type sugar transport system, permease component
SPNOXC_RS09040	COG1175	transmembrane transport
SPNOXC_RS09045	COG1653	transport
SPNOXC_RS09050	COG3345	alpha-galactosidase
SPNOXC_RS09055	COG2207	Transcriptional regulator
SPNOXC_RS09060	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPNOXC_RS09060	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPNOXC_RS09175	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPNOXC_RS09215	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SPNOXC_RS09225	COG4221	oxidoreductase activity
SPNOXC_RS09230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPNOXC_RS09235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPNOXC_RS09270	COG1132	(ABC) transporter
SPNOXC_RS09360	COG5263	repeat protein
SPNOXC_RS09360	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPNOXC_RS09380	COG1316	TRANSCRIPTIONal
SPNOXC_RS09390	COG0802	atpase or kinase
SPNOXC_RS09415	COG1136	(ABC) transporter
SPNOXC_RS09415	COG0577	efflux transmembrane transporter activity
SPNOXC_RS09445	COG1253	flavin adenine dinucleotide binding
SPNOXC_RS09460	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPNOXC_RS09465	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPNOXC_RS09475	COG0742	ribosomal rna small subunit methyltransferase
SPNOXC_RS09495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPNOXC_RS09500	COG1254	Belongs to the acylphosphatase family
SPNOXC_RS09510	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPNOXC_RS09520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPNOXC_RS09535	COG1564	THIamine pyrophosphokinase
SPNOXC_RS09545	COG1162	GTPase activity
SPNOXC_RS09580	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SPNOXC_RS09585	COG0084	hydrolase, TatD family'
SPNOXC_RS09600	COG0436	Aminotransferase
SPNOXC_RS09610	COG0589	response to stress
SPNOXC_RS09615	COG0561	phosphatase activity
SPNOXC_RS09620	COG0252	asparaginase activity
SPNOXC_RS09630	COG1609	Transcriptional regulator
SPNOXC_RS09635	COG2197	response regulator
SPNOXC_RS09640	COG4585	Histidine kinase
SPNOXC_RS09645	COG0842	Transport permease protein
SPNOXC_RS09650	COG1131	(ABC) transporter
SPNOXC_RS09750	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPNOXC_RS09755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPNOXC_RS09760	COG0564	pseudouridine synthase activity
SPNOXC_RS09770	COG0577	efflux transmembrane transporter activity
SPNOXC_RS09770	COG1136	(ABC) transporter
SPNOXC_RS09790	COG0157	Belongs to the NadC ModD family
SPNOXC_RS09800	COG4133	protoheme IX ABC transporter activity
SPNOXC_RS09805	COG2188	Transcriptional regulator
SPNOXC_RS09810	COG2723	6-phospho-beta-galactosidase activity
SPNOXC_RS09815	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPNOXC_RS09825	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPNOXC_RS09830	COG1012	belongs to the aldehyde dehydrogenase family
SPNOXC_RS09830	COG1454	alcohol dehydrogenase
SPNOXC_RS09840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPNOXC_RS09850	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SPNOXC_RS09870	COG3623	hexulose-6-phosphate isomerase
SPNOXC_RS09880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPNOXC_RS09900	COG1847	R3H domain protein
SPNOXC_RS09905	COG0706	membrane insertase activity
SPNOXC_RS09955	COG4537	Required for transformation and DNA binding
SPNOXC_RS09960	COG1459	type II secretion system
SPNOXC_RS09965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPNOXC_RS09975	COG1063	alcohol dehydrogenase
SPNOXC_RS10000	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SPNOXC_RS10005	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SPNOXC_RS10010	COG3759	membrane
SPNOXC_RS10025	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SPNOXC_RS10025	COG0131	Imidazoleglycerol-phosphate dehydratase
SPNOXC_RS10030	COG0534	Mate efflux family protein
SPNOXC_RS10145	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPNOXC_RS10150	COG1132	(ABC) transporter
SPNOXC_RS10160	COG1132	(ABC) transporter
SPNOXC_RS10170	COG1438	arginine binding
SPNOXC_RS10190	COG0745	RESPONSE REGULATOR receiver
SPNOXC_RS10195	COG5002	protein histidine kinase activity
SPNOXC_RS10200	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPNOXC_RS10205	COG0573	inorganic phosphate transmembrane transporter activity
SPNOXC_RS10215	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPNOXC_RS10220	COG0704	Plays a role in the regulation of phosphate uptake
SPNOXC_RS10240	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPNOXC_RS10250	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPNOXC_RS10265	COG0697	spore germination
SPNOXC_RS10270	COG4499	WXG100 protein secretion system (Wss), protein YukC
SPNOXC_RS10270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPNOXC_RS10280	COG2217	Heavy metal translocating P-type atpase
SPNOXC_RS10290	COG2226	methyltransferase
SPNOXC_RS10315	COG0058	SHG alpha-glucan phosphorylase activity
SPNOXC_RS10320	COG1640	4-alpha-glucanotransferase
SPNOXC_RS10325	COG2182	Extracellular solute-binding protein
SPNOXC_RS10330	COG1175	transmembrane transport
SPNOXC_RS10335	COG3833	ABC-type maltose transport systems, permease component
SPNOXC_RS10340	COG5521	maltodextrose utilization protein MalA
SPNOXC_RS10345	COG1609	Transcriptional regulator
SPNOXC_RS10350	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPNOXC_RS10385	COG1476	TRANSCRIPTIONal
SPNOXC_RS10415	COG2151	metal-sulfur cluster biosynthetic enzyme
SPNOXC_RS10430	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPNOXC_RS10435	COG3959	Transketolase, thiamine diphosphate binding domain
SPNOXC_RS10450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPNOXC_RS10470	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPNOXC_RS10485	COG0383	alpha-mannosidase activity
SPNOXC_RS10495	COG3537	Alpha-1,2-mannosidase
SPNOXC_RS10515	COG0549	Belongs to the carbamate kinase family
SPNOXC_RS10520	COG1288	antiporter activity
SPNOXC_RS10525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPNOXC_RS10540	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPNOXC_RS10540	COG3583	domain protein
SPNOXC_RS10540	COG3064	Membrane
SPNOXC_RS10550	COG1454	alcohol dehydrogenase
SPNOXC_RS10555	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
SPNOXC_RS10560	COG0235	Class ii aldolase
SPNOXC_RS10590	COG1175	transmembrane transport
SPNOXC_RS10595	COG1653	transport
SPNOXC_RS10600	COG1070	Carbohydrate kinase
SPNOXC_RS10610	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPNOXC_RS10610	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPNOXC_RS10615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPNOXC_RS10620	COG1121	(ABC) transporter
SPNOXC_RS10625	COG1846	Transcriptional regulator
SPNOXC_RS10630	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPNOXC_RS10640	COG1696	Membrane protein involved in D-alanine export
SPNOXC_RS10655	COG2211	Major facilitator Superfamily
SPNOXC_RS10660	COG3344	reverse transcriptase
SPNOXC_RS10675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPNOXC_RS10680	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SPNOXC_RS10700	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPNOXC_RS10710	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPNOXC_RS10715	COG5002	protein histidine kinase activity
SPNOXC_RS10720	COG0745	RESPONSE REGULATOR receiver
SPNOXC_RS10730	COG0542	response to heat
SPNOXC_RS10735	COG4463	regulation of RNA biosynthetic process
SPNOXC_RS10740	COG1116	anion transmembrane transporter activity
SPNOXC_RS10745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SPNOXC_RS10750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SPNOXC_RS10770	COG0305	Participates in initiation and elongation during chromosome replication
SPNOXC_RS10790	COG1040	competence protein
SPNOXC_RS10795	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPNOXC_RS10800	COG1739	Uncharacterized protein family UPF0029
SPNOXC_RS10815	COG3335	DDE superfamily endonuclease
SPNOXC_RS10835	COG3942	CHAP domain
SPNOXC_RS10845	COG1792	Involved in formation and maintenance of cell shape
SPNOXC_RS10850	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPNOXC_RS10855	COG1122	ATPase activity
SPNOXC_RS10860	COG1122	ATPase activity
SPNOXC_RS10865	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPNOXC_RS10875	COG0612	Peptidase, M16
SPNOXC_RS10880	COG0612	Peptidase, M16
SPNOXC_RS10885	COG2501	S4 domain
SPNOXC_RS10895	COG0517	IMP dehydrogenase activity
SPNOXC_RS10895	COG0516	GMP reductase activity
SPNOXC_RS10900	COG0180	Tryptophanyl-tRNA synthetase
SPNOXC_RS10905	COG0488	(ABC) transporter
SPNOXC_RS10915	COG1511	domain protein
SPNOXC_RS10925	COG1511	domain protein
SPNOXC_RS10970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPNOXC_RS10975	COG1475	DNA binding