locus-tag	class	description
SPP_RS00010	COG0592	DNA-directed DNA polymerase activity
SPP_RS00020	COG0012	GTP binding
SPP_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPP_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPP_RS00060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SPP_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPP_RS00265	COG0582	viral genome integration into host DNA
SPP_RS00395	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPP_RS00395	COG5263	repeat protein
SPP_RS00410	COG0756	dUTP diphosphatase activity
SPP_RS00420	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SPP_RS00440	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPP_RS00460	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPP_RS00460	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPP_RS00465	COG1832	CoA-binding protein
SPP_RS00475	COG2855	membrane
SPP_RS00480	COG0436	Aminotransferase
SPP_RS00495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPP_RS00520	COG2274	protein secretion by the type I secretion system
SPP_RS00525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPP_RS00535	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPP_RS00550	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPP_RS00565	COG0151	Belongs to the GarS family
SPP_RS00570	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPP_RS00585	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPP_RS00590	COG3064	Membrane
SPP_RS00590	COG3583	domain protein
SPP_RS00590	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPP_RS00605	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPP_RS00610	COG3715	PTS system
SPP_RS00615	COG3716	PTS system mannose fructose sorbose family IID component
SPP_RS00625	COG2222	sugar isomerase
SPP_RS00635	COG2514	catechol 2,3-dioxygenase activity
SPP_RS00670	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPP_RS00675	COG0569	domain protein
SPP_RS00705	COG5002	protein histidine kinase activity
SPP_RS00725	COG4209	transmembrane transport
SPP_RS00730	COG0395	ABC-type sugar transport system, permease component
SPP_RS00735	COG1653	transport
SPP_RS00765	COG1695	Transcriptional regulator
SPP_RS00790	COG0546	phosphoglycolate phosphatase activity
SPP_RS00795	COG1760	l-serine dehydratase
SPP_RS00800	COG1760	l-serine dehydratase
SPP_RS00825	COG0577	efflux transmembrane transporter activity
SPP_RS00825	COG1136	(ABC) transporter
SPP_RS00830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPP_RS00920	COG0445	tRNA wobble uridine modification
SPP_RS00955	COG1214	PFAM Peptidase M22, glycoprotease
SPP_RS01050	COG1396	sequence-specific DNA binding
SPP_RS01080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPP_RS01085	COG1464	Belongs to the NlpA lipoprotein family
SPP_RS01090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPP_RS01095	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPP_RS01115	COG2972	Histidine kinase
SPP_RS01120	COG4753	response regulator
SPP_RS01120	COG2207	Transcriptional regulator
SPP_RS01130	COG1780	Probably involved in ribonucleotide reductase function
SPP_RS01160	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPP_RS01160	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPP_RS01180	COG2818	Glycosylase
SPP_RS01205	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPP_RS01210	COG0006	proline dipeptidase activity
SPP_RS01215	COG1393	Belongs to the ArsC family
SPP_RS01240	COG0285	dihydrofolate synthase activity
SPP_RS01250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPP_RS01280	COG0602	queuosine metabolic process
SPP_RS01315	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPP_RS01340	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SPP_RS01380	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SPP_RS01395	COG0201	protein transport
SPP_RS01405	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SPP_RS01410	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SPP_RS01420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SPP_RS01425	COG0202	RNA polymerase activity
SPP_RS01435	COG3830	Belongs to the UPF0237 family
SPP_RS01475	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPP_RS01480	COG1349	DNA-binding transcription factor activity
SPP_RS01490	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPP_RS01495	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPP_RS01500	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPP_RS01505	COG1882	Formate acetyltransferase
SPP_RS01550	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPP_RS01555	COG4589	Belongs to the CDS family
SPP_RS01560	COG0750	zinc metalloprotease
SPP_RS01570	COG2723	6-phospho-beta-galactosidase activity
SPP_RS01575	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPP_RS01590	COG1523	belongs to the glycosyl hydrolase 13 family
SPP_RS01610	COG2176	DNA-directed DNA polymerase activity
SPP_RS01630	COG2309	aminopeptidase activity
SPP_RS01635	COG2261	transglycosylase associated protein
SPP_RS01640	COG1187	pseudouridine synthase activity
SPP_RS01650	COG3579	cysteine-type endopeptidase activity
SPP_RS01655	COG3716	PTS system mannose fructose sorbose family IID component
SPP_RS01660	COG3715	PTS system
SPP_RS01670	COG1064	alcohol dehydrogenase
SPP_RS01675	COG0561	phosphatase activity
SPP_RS01680	COG2252	PERMEase
SPP_RS01690	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SPP_RS01695	COG0285	dihydrofolate synthase activity
SPP_RS01705	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SPP_RS01705	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPP_RS01715	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPP_RS01740	COG0386	Belongs to the glutathione peroxidase family
SPP_RS01745	COG5492	domain, Protein
SPP_RS01770	COG1028	Short-chain dehydrogenase reductase Sdr
SPP_RS01780	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SPP_RS01785	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPP_RS01790	COG3715	PTS system
SPP_RS01795	COG3716	PTS system mannose fructose sorbose family IID component
SPP_RS01810	COG1609	Transcriptional regulator
SPP_RS01840	COG4839	cell division protein FtsL
SPP_RS01845	COG0768	penicillin binding
SPP_RS01875	COG0366	Alpha amylase catalytic
SPP_RS01880	COG4166	transmembrane transport
SPP_RS01920	COG3944	biosynthesis protein
SPP_RS01980	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SPP_RS01990	COG1088	dTDP-glucose 4,6-dehydratase activity
SPP_RS02005	COG4372	Transposase
SPP_RS02010	COG4166	transmembrane transport
SPP_RS02015	COG0366	Alpha amylase catalytic
SPP_RS02020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPP_RS02045	COG0116	Belongs to the methyltransferase superfamily
SPP_RS02055	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SPP_RS02060	COG0745	RESPONSE REGULATOR receiver
SPP_RS02110	COG4585	Histidine kinase
SPP_RS02115	COG2197	response regulator
SPP_RS02145	COG0582	viral genome integration into host DNA
SPP_RS02155	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPP_RS02160	COG0681	Belongs to the peptidase S26 family
SPP_RS02185	COG1115	amino acid carrier protein
SPP_RS02210	COG0527	aspartate kinase activity
SPP_RS02215	COG1024	Enoyl-CoA hydratase
SPP_RS02220	COG1846	Transcriptional regulator
SPP_RS02230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPP_RS02240	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPP_RS02245	COG1028	Short-chain dehydrogenase reductase Sdr
SPP_RS02250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPP_RS02265	COG0439	Biotin carboxylase
SPP_RS02270	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPP_RS02310	COG1063	alcohol dehydrogenase
SPP_RS02335	COG1442	glycosyl transferase family 8
SPP_RS02340	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SPP_RS02350	COG1461	Dihydroxyacetone kinase
SPP_RS02355	COG0028	Belongs to the TPP enzyme family
SPP_RS02360	COG0440	acetolactate synthase activity
SPP_RS02380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SPP_RS02395	COG0765	amino acid transport
SPP_RS02425	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPP_RS02430	COG1882	Formate acetyltransferase
SPP_RS02460	COG1940	carbohydrate kinase activity
SPP_RS02460	COG1846	Transcriptional regulator
SPP_RS02465	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPP_RS02475	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPP_RS02480	COG2723	6-phospho-beta-galactosidase activity
SPP_RS02485	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPP_RS02485	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPP_RS02490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPP_RS02495	COG0569	domain protein
SPP_RS02515	COG1122	ATPase activity
SPP_RS02530	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPP_RS02535	COG0671	phosphoesterase, PA-phosphatase related
SPP_RS02545	COG1247	-acetyltransferase
SPP_RS02555	COG0504	CTP synthase activity
SPP_RS02560	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPP_RS02580	COG0789	Transcriptional regulator
SPP_RS02585	COG0174	glutamine synthetase
SPP_RS02600	COG4974	Belongs to the 'phage' integrase family
SPP_RS02610	COG0732	type I restriction modification DNA specificity domain
SPP_RS02660	COG0484	heat shock protein binding
SPP_RS02670	COG0537	adenosine 5'-monophosphoramidase activity
SPP_RS02675	COG1131	(ABC) transporter
SPP_RS02700	COG3290	protein histidine kinase activity
SPP_RS02710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPP_RS02715	COG2274	protein secretion by the type I secretion system
SPP_RS02775	COG1266	CAAX protease self-immunity
SPP_RS02795	COG0195	Participates in both transcription termination and antitermination
SPP_RS02800	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPP_RS02865	COG0519	Catalyzes the synthesis of GMP from XMP
SPP_RS02875	COG0525	valine-tRNA ligase activity
SPP_RS02890	COG2801	Transposase and inactivated derivatives
SPP_RS02925	COG3711	transcriptional antiterminator
SPP_RS02930	COG2190	(PTS) system
SPP_RS02930	COG1263	PTS System
SPP_RS02930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPP_RS02945	COG0456	acetyltransferase
SPP_RS02950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPP_RS02950	COG0072	phenylalanine-tRNA ligase activity
SPP_RS02970	COG3620	sequence-specific DNA binding
SPP_RS02995	COG1045	serine acetyltransferase
SPP_RS03005	COG0215	cysteine-tRNA ligase activity
SPP_RS03010	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPP_RS03030	COG0577	efflux transmembrane transporter activity
SPP_RS03035	COG1136	(ABC) transporter
SPP_RS03040	COG0577	efflux transmembrane transporter activity
SPP_RS03045	COG0745	RESPONSE REGULATOR receiver
SPP_RS03050	COG5002	protein histidine kinase activity
SPP_RS03055	COG0191	fructose-bisphosphate aldolase activity
SPP_RS03060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SPP_RS03065	COG0765	amino acid transport
SPP_RS03070	COG0765	amino acid transport
SPP_RS03075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPP_RS03085	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPP_RS03085	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPP_RS03125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPP_RS03140	COG1573	uracil-dna glycosylase
SPP_RS03150	COG1114	Component of the transport system for branched-chain amino acids
SPP_RS03155	COG1363	Peptidase, m42
SPP_RS03200	COG4555	ABC transporter
SPP_RS03235	COG1404	Belongs to the peptidase S8 family
SPP_RS03255	COG3775	system Galactitol-specific IIC component
SPP_RS03260	COG3250	beta-galactosidase activity
SPP_RS03285	COG1242	4 iron, 4 sulfur cluster binding
SPP_RS03310	COG0785	Cytochrome C biogenesis protein
SPP_RS03315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPP_RS03320	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPP_RS03320	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPP_RS03325	COG2207	Transcriptional regulator
SPP_RS03325	COG4753	response regulator
SPP_RS03330	COG2972	Histidine kinase
SPP_RS03340	COG3064	Membrane
SPP_RS03345	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPP_RS03360	COG1940	carbohydrate kinase activity
SPP_RS03380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPP_RS03385	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPP_RS03395	COG0300	oxidoreductase activity
SPP_RS03410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPP_RS03420	COG1187	pseudouridine synthase activity
SPP_RS03425	COG1217	gtp-binding protein TYPA
SPP_RS03445	COG1136	(ABC) transporter
SPP_RS03460	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SPP_RS03470	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SPP_RS03495	COG1131	(ABC) transporter
SPP_RS03500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPP_RS03520	COG1304	FMN binding
SPP_RS03530	COG1304	FMN binding
SPP_RS03545	COG0352	thiamine-phosphate diphosphorylase activity
SPP_RS03555	COG4172	Belongs to the ABC transporter superfamily
SPP_RS03565	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SPP_RS03580	COG0352	thiamine-phosphate diphosphorylase activity
SPP_RS03600	COG2217	Heavy metal translocating P-type atpase
SPP_RS03605	COG0028	Belongs to the TPP enzyme family
SPP_RS03620	COG3335	DDE superfamily endonuclease
SPP_RS03630	COG2723	6-phospho-beta-galactosidase activity
SPP_RS03635	COG1482	cell wall glycoprotein biosynthetic process
SPP_RS03640	COG0733	neurotransmitter:sodium symporter activity
SPP_RS03650	COG0789	Transcriptional regulator
SPP_RS03660	COG2081	HI0933 family
SPP_RS03665	COG1307	EDD domain protein, DegV family
SPP_RS03675	COG2131	deaminase
SPP_RS03680	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SPP_RS03720	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPP_RS03720	COG0617	tRNA 3'-terminal CCA addition
SPP_RS03720	COG0517	IMP dehydrogenase activity
SPP_RS03725	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SPP_RS03730	COG2884	Cell division ATP-binding protein ftsE
SPP_RS03735	COG2177	Part of the ABC transporter FtsEX involved in
SPP_RS03740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPP_RS03740	COG2190	(PTS) system
SPP_RS03740	COG1263	PTS System
SPP_RS03750	COG0513	Belongs to the DEAD box helicase family
SPP_RS03760	COG0167	dihydroorotate dehydrogenase activity
SPP_RS03770	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SPP_RS03775	COG4470	Protein conserved in bacteria
SPP_RS03790	COG0488	(ABC) transporter
SPP_RS03815	COG1837	Belongs to the UPF0109 family
SPP_RS03835	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPP_RS03835	COG1328	CTP reductase activity
SPP_RS03845	COG4443	Transcriptional Coactivator p15 (PC4)
SPP_RS03855	COG1268	BioY protein
SPP_RS03860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPP_RS03865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPP_RS03870	COG1136	(ABC) transporter
SPP_RS03875	COG0577	efflux transmembrane transporter activity
SPP_RS03880	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPP_RS03880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPP_RS03900	COG4989	oxidoreductase activity
SPP_RS03910	COG1028	Short-chain dehydrogenase reductase Sdr
SPP_RS03935	COG0745	RESPONSE REGULATOR receiver
SPP_RS03940	COG5002	protein histidine kinase activity
SPP_RS03960	COG0772	Belongs to the SEDS family
SPP_RS03965	COG0693	protein deglycase activity
SPP_RS03975	COG0187	DNA topoisomerase II activity
SPP_RS04005	COG3335	DDE superfamily endonuclease
SPP_RS04030	COG2801	Transposase and inactivated derivatives
SPP_RS04040	COG0494	nUDIX hydrolase
SPP_RS04060	COG0542	response to heat
SPP_RS04065	COG4703	Protein of unknown function (DUF1797)
SPP_RS04070	COG0765	amino acid transport
SPP_RS04075	COG1126	abc transporter atp-binding protein
SPP_RS04080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPP_RS04085	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SPP_RS04105	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SPP_RS04155	COG2813	Specifically methylates the guanine in position
SPP_RS04160	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SPP_RS04170	COG0295	cytidine deaminase activity
SPP_RS04175	COG1744	ABC transporter substrate-binding protein PnrA-like
SPP_RS04180	COG3845	ABC transporter
SPP_RS04185	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPP_RS04190	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPP_RS04210	COG2801	Transposase and inactivated derivatives
SPP_RS04220	COG0187	DNA topoisomerase II activity
SPP_RS04230	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPP_RS04235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPP_RS04240	COG4166	transmembrane transport
SPP_RS04275	COG0539	negative regulation of cytoplasmic translation
SPP_RS04280	COG1956	GAF domain-containing protein
SPP_RS04285	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPP_RS04300	COG0719	Fe-S assembly protein
SPP_RS04305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPP_RS04315	COG0719	Fe-S assembly protein
SPP_RS04325	COG1686	Belongs to the peptidase S11 family
SPP_RS04330	COG0628	permease
SPP_RS04340	COG1349	DNA-binding transcription factor activity
SPP_RS04345	COG1105	Belongs to the carbohydrate kinase PfkB family
SPP_RS04350	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPP_RS04350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPP_RS04350	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPP_RS04355	COG1674	ftsk spoiiie
SPP_RS04355	COG0697	spore germination
SPP_RS04365	COG1104	cysteine desulfurase activity
SPP_RS04420	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
SPP_RS04430	COG1438	arginine binding
SPP_RS04450	COG0469	pyruvate kinase activity
SPP_RS04455	COG0582	viral genome integration into host DNA
SPP_RS04490	COG3689	TIGRFAM TIGR03943 family protein
SPP_RS04495	COG0701	Predicted permease
SPP_RS04505	COG2183	response to ionizing radiation
SPP_RS04525	COG1136	(ABC) transporter
SPP_RS04530	COG0577	efflux transmembrane transporter activity
SPP_RS04545	COG1982	Orn Lys Arg decarboxylase major
SPP_RS04560	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SPP_RS04580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPP_RS04585	COG0561	phosphatase activity
SPP_RS04605	COG0583	DNA-binding transcription factor activity
SPP_RS04610	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPP_RS04615	COG0564	pseudouridine synthase activity
SPP_RS04620	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPP_RS04635	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPP_RS04645	COG0470	DNA polymerase III
SPP_RS04690	COG0528	UMP kinase activity
SPP_RS04700	COG2996	Protein conserved in bacteria
SPP_RS04710	COG1702	phosphate starvation-inducible protein PhoH
SPP_RS04725	COG0686	Belongs to the AlaDH PNT family
SPP_RS04730	COG0686	Belongs to the AlaDH PNT family
SPP_RS04735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPP_RS04740	COG1596	polysaccharide export
SPP_RS04740	COG1555	photosystem II stabilization
SPP_RS04745	COG0658	competence protein
SPP_RS04745	COG2333	competence protein COMEC
SPP_RS04755	COG1131	(ABC) transporter
SPP_RS04785	COG0543	2 iron, 2 sulfur cluster binding
SPP_RS04790	COG0167	dihydroorotate dehydrogenase activity
SPP_RS04795	COG4193	domain, Protein
SPP_RS04795	COG5263	repeat protein
SPP_RS04800	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPP_RS04810	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPP_RS04820	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPP_RS04825	COG0237	dephospho-CoA kinase activity
SPP_RS04830	COG2814	Major facilitator Superfamily
SPP_RS04835	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPP_RS04845	COG0557	exoribonuclease II activity
SPP_RS04855	COG3615	Tellurite resistance protein tehB
SPP_RS04855	COG0500	methyltransferase
SPP_RS04870	COG4122	O-methyltransferase activity
SPP_RS04880	COG2801	Transposase and inactivated derivatives
SPP_RS04900	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SPP_RS04920	COG0494	nUDIX hydrolase
SPP_RS04930	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPP_RS04940	COG2176	DNA-directed DNA polymerase activity
SPP_RS04945	COG0584	glycerophosphoryl diester phosphodiesterase
SPP_RS04970	COG0785	Cytochrome C biogenesis protein
SPP_RS04975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPP_RS04980	COG0531	amino acid
SPP_RS04985	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPP_RS04985	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPP_RS05025	COG1970	mechanosensitive ion channel activity
SPP_RS05035	COG4708	membrane
SPP_RS05045	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPP_RS05055	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SPP_RS05060	COG1942	4-Oxalocrotonate Tautomerase
SPP_RS05065	COG1435	thymidine kinase activity
SPP_RS05080	COG2890	protein-(glutamine-N5) methyltransferase activity
SPP_RS05105	COG0741	lytic transglycosylase activity
SPP_RS05115	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPP_RS05135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPP_RS05140	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPP_RS05165	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SPP_RS05195	COG1597	lipid kinase activity
SPP_RS05215	COG1396	sequence-specific DNA binding
SPP_RS05220	COG0542	response to heat
SPP_RS05225	COG0613	PHP domain protein
SPP_RS05280	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPP_RS05300	COG1396	sequence-specific DNA binding
SPP_RS05310	COG0772	Belongs to the SEDS family
SPP_RS05315	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SPP_RS05330	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPP_RS05335	COG0358	DNA primase activity
SPP_RS05340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPP_RS05345	COG2151	metal-sulfur cluster biosynthetic enzyme
SPP_RS05350	COG0438	transferase activity, transferring glycosyl groups
SPP_RS05355	COG0438	transferase activity, transferring glycosyl groups
SPP_RS05380	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPP_RS05390	COG4109	DRTGG domain
SPP_RS05395	COG0024	Methionine aminopeptidase
SPP_RS05415	COG0210	DNA helicase
SPP_RS05425	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPP_RS05445	COG1104	cysteine desulfurase activity
SPP_RS05450	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPP_RS05460	COG2357	RelA SpoT domain protein
SPP_RS05470	COG0564	pseudouridine synthase activity
SPP_RS05475	COG0280	phosphate acetyltransferase
SPP_RS05525	COG0196	riboflavin kinase activity
SPP_RS05530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPP_RS05535	COG1307	EDD domain protein, DegV family
SPP_RS05545	COG0488	(ABC) transporter
SPP_RS05565	COG1523	belongs to the glycosyl hydrolase 13 family
SPP_RS05580	COG1012	belongs to the aldehyde dehydrogenase family
SPP_RS05585	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SPP_RS05595	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SPP_RS05605	COG0560	Phosphoserine phosphatase
SPP_RS05630	COG0582	viral genome integration into host DNA
SPP_RS05645	COG1074	ATP-dependent DNA helicase activity
SPP_RS05660	COG3583	domain protein
SPP_RS05660	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
SPP_RS05665	COG3064	Membrane
SPP_RS05675	COG0270	DNA (cytosine-5-)-methyltransferase activity
SPP_RS05730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SPP_RS05740	COG0741	lytic transglycosylase activity
SPP_RS05740	COG0791	NLP P60 protein
SPP_RS05770	COG2946	Replication initiation factor
SPP_RS05775	COG1674	ftsk spoiiie
SPP_RS05885	COG1396	sequence-specific DNA binding
SPP_RS05890	COG0542	response to heat
SPP_RS05900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPP_RS05925	COG3843	relaxase mobilization nuclease domain protein
SPP_RS05940	COG0582	viral genome integration into host DNA
SPP_RS05945	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPP_RS05965	COG0095	Lipoate-protein ligase
SPP_RS05970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPP_RS05975	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPP_RS05980	COG0022	dehydrogenase e1 component
SPP_RS05985	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPP_RS05990	COG0534	Mate efflux family protein
SPP_RS06000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPP_RS06005	COG1051	belongs to the nudix hydrolase family
SPP_RS06020	COG1011	Hydrolase
SPP_RS06050	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPP_RS06055	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPP_RS06060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPP_RS06065	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPP_RS06075	COG2723	6-phospho-beta-galactosidase activity
SPP_RS06090	COG3711	transcriptional antiterminator
SPP_RS06095	COG3684	Belongs to the aldolase LacD family
SPP_RS06150	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SPP_RS06155	COG0497	DNA recombination
SPP_RS06160	COG1438	arginine binding
SPP_RS06165	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPP_RS06200	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SPP_RS06220	COG3764	Sortase (surface protein transpeptidase)
SPP_RS06225	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPP_RS06235	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SPP_RS06250	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPP_RS06255	COG5002	protein histidine kinase activity
SPP_RS06260	COG0745	RESPONSE REGULATOR receiver
SPP_RS06265	COG1194	a g-specific adenine glycosylase
SPP_RS06280	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPP_RS06285	COG4684	Psort location CytoplasmicMembrane, score
SPP_RS06295	COG1827	regulation of RNA biosynthetic process
SPP_RS06325	COG0765	amino acid transport
SPP_RS06330	COG1126	abc transporter atp-binding protein
SPP_RS06335	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPP_RS06340	COG0552	protein localization to endoplasmic reticulum
SPP_RS06345	COG0561	phosphatase activity
SPP_RS06350	COG0561	phosphatase activity
SPP_RS06355	COG1196	nuclear chromosome segregation
SPP_RS06380	COG1401	restriction endodeoxyribonuclease activity
SPP_RS06395	COG0066	3-isopropylmalate dehydratase activity
SPP_RS06405	COG0473	3-isopropylmalate dehydrogenase activity
SPP_RS06425	COG3142	Participates in the control of copper homeostasis
SPP_RS06430	COG2832	Protein of unknown function (DUF454)
SPP_RS06435	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPP_RS06445	COG0758	DNA mediated transformation
SPP_RS06450	COG4750	Nucleotidyl transferase
SPP_RS06465	COG1063	alcohol dehydrogenase
SPP_RS06480	COG3475	LICD family
SPP_RS06485	COG3475	LICD family
SPP_RS06495	COG0505	Belongs to the CarA family
SPP_RS06510	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPP_RS06520	COG0488	(ABC) transporter
SPP_RS06530	COG1704	LemA family
SPP_RS06545	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPP_RS06560	COG1078	dGTPase activity
SPP_RS06585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPP_RS06590	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPP_RS06595	COG0077	Prephenate dehydratase
SPP_RS06595	COG1605	Chorismate mutase
SPP_RS06600	COG0716	FMN binding
SPP_RS06605	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPP_RS06630	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPP_RS06660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPP_RS06665	COG0295	cytidine deaminase activity
SPP_RS06670	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SPP_RS06680	COG4608	Belongs to the ABC transporter superfamily
SPP_RS06690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPP_RS06695	COG0601	transmembrane transport
SPP_RS06710	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SPP_RS06750	COG0270	DNA (cytosine-5-)-methyltransferase activity
SPP_RS06775	COG0402	S-adenosylhomocysteine deaminase activity
SPP_RS06785	COG1132	(ABC) transporter
SPP_RS06790	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPP_RS06790	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPP_RS06825	COG1215	transferase activity, transferring glycosyl groups
SPP_RS06835	COG3475	LICD family
SPP_RS06845	COG0077	Prephenate dehydratase
SPP_RS06850	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SPP_RS06865	COG0287	Prephenate dehydrogenase
SPP_RS06890	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPP_RS06900	COG4555	ABC transporter
SPP_RS06940	COG3842	ATPase activity
SPP_RS06955	COG3527	Alpha-acetolactate decarboxylase
SPP_RS06960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPP_RS06970	COG0704	Plays a role in the regulation of phosphate uptake
SPP_RS06975	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPP_RS06980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPP_RS06985	COG0581	inorganic phosphate transmembrane transporter activity
SPP_RS06990	COG0573	inorganic phosphate transmembrane transporter activity
SPP_RS06995	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPP_RS07000	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPP_RS07000	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPP_RS07005	COG0483	inositol monophosphate 1-phosphatase activity
SPP_RS07015	COG1393	Belongs to the ArsC family
SPP_RS07025	COG0647	UMP catabolic process
SPP_RS07035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPP_RS07095	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPP_RS07120	COG1131	(ABC) transporter
SPP_RS07130	COG0826	peptidase U32
SPP_RS07135	COG0826	peptidase U32
SPP_RS07160	COG1132	(ABC) transporter
SPP_RS07165	COG1132	(ABC) transporter
SPP_RS07180	COG1129	ABC transporter
SPP_RS07220	COG2188	Transcriptional regulator
SPP_RS07225	COG0697	spore germination
SPP_RS07230	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPP_RS07245	COG0561	phosphatase activity
SPP_RS07275	COG0492	ferredoxin-NADP+ reductase activity
SPP_RS07285	COG1126	abc transporter atp-binding protein
SPP_RS07295	COG1393	Belongs to the ArsC family
SPP_RS07315	COG1272	protein, Hemolysin III
SPP_RS07345	COG0431	NADPH-dependent FMN reductase
SPP_RS07345	COG3976	FMN-binding domain protein
SPP_RS07345	COG1053	succinate dehydrogenase
SPP_RS07370	COG0656	L-ascorbic acid biosynthetic process
SPP_RS07375	COG0726	polysaccharide deacetylase
SPP_RS07400	COG3335	DDE superfamily endonuclease
SPP_RS07415	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPP_RS07450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPP_RS07460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPP_RS07465	COG1126	abc transporter atp-binding protein
SPP_RS07480	COG0628	permease
SPP_RS07485	COG2706	6-phosphogluconolactonase activity
SPP_RS07550	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPP_RS07575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPP_RS07580	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SPP_RS07585	COG0626	cystathionine gamma-synthase activity
SPP_RS07590	COG1132	(ABC) transporter
SPP_RS07605	COG1132	(ABC) transporter
SPP_RS07610	COG4166	transmembrane transport
SPP_RS07615	COG2244	polysaccharide biosynthetic process
SPP_RS07620	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPP_RS07650	COG2827	Endonuclease containing a URI domain
SPP_RS07655	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPP_RS07660	COG1098	S1 RNA binding domain
SPP_RS07670	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPP_RS07675	COG0629	single-stranded DNA binding
SPP_RS07685	COG0017	Asparaginyl-tRNA synthetase
SPP_RS07695	COG0436	Aminotransferase
SPP_RS07735	COG0242	peptide deformylase activity
SPP_RS07740	COG0625	glutathione transferase activity
SPP_RS07750	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPP_RS07755	COG0488	(ABC) transporter
SPP_RS07770	COG1307	EDD domain protein, DegV family
SPP_RS07790	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPP_RS07810	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SPP_RS07820	COG0251	oxidation-reduction process
SPP_RS07840	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPP_RS07850	COG5263	repeat protein
SPP_RS07850	COG4193	domain, Protein
SPP_RS07860	COG3935	DnaD domain protein
SPP_RS07875	COG2226	methyltransferase
SPP_RS07885	COG3842	ATPase activity
SPP_RS07895	COG1335	isochorismatase
SPP_RS07905	COG0513	Belongs to the DEAD box helicase family
SPP_RS07910	COG2223	nitrite transmembrane transporter activity
SPP_RS07915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPP_RS07920	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPP_RS07925	COG3442	glutamine amidotransferase
SPP_RS07930	COG0006	proline dipeptidase activity
SPP_RS07935	COG2801	Transposase and inactivated derivatives
SPP_RS07950	COG4720	Psort location CytoplasmicMembrane, score
SPP_RS07955	COG0351	phosphomethylpyrimidine kinase
SPP_RS07980	COG2824	Alkylphosphonate utilization operon protein PhnA
SPP_RS08000	COG0463	Glycosyl transferase, family 2
SPP_RS08005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPP_RS08015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPP_RS08020	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SPP_RS08025	COG2384	SAM-dependent methyltransferase
SPP_RS08045	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SPP_RS08050	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SPP_RS08055	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPP_RS08055	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPP_RS08055	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
SPP_RS08060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPP_RS08080	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SPP_RS08085	COG0204	Acyl-transferase
SPP_RS08100	COG2910	NAD(P)H-binding
SPP_RS08120	COG5002	protein histidine kinase activity
SPP_RS08125	COG0745	RESPONSE REGULATOR receiver
SPP_RS08140	COG1959	2 iron, 2 sulfur cluster binding
SPP_RS08195	COG3590	peptidase
SPP_RS08210	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPP_RS08215	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SPP_RS08225	COG1136	(ABC) transporter
SPP_RS08225	COG0577	efflux transmembrane transporter activity
SPP_RS08270	COG3599	regulation of cell shape
SPP_RS08290	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPP_RS08310	COG1051	belongs to the nudix hydrolase family
SPP_RS08315	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPP_RS08330	COG0768	penicillin binding
SPP_RS08345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPP_RS08365	COG2731	YhcH YjgK YiaL family protein
SPP_RS08370	COG0395	ABC-type sugar transport system, permease component
SPP_RS08375	COG1175	transmembrane transport
SPP_RS08385	COG1263	PTS System
SPP_RS08385	COG2190	(PTS) system
SPP_RS08385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPP_RS08395	COG0673	inositol 2-dehydrogenase activity
SPP_RS08400	COG4409	exo-alpha-(2->6)-sialidase activity
SPP_RS08410	COG1175	transmembrane transport
SPP_RS08415	COG1653	transport
SPP_RS08440	COG3458	cephalosporin-C deacetylase activity
SPP_RS08445	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPP_RS08460	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPP_RS08465	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPP_RS08480	COG1131	(ABC) transporter
SPP_RS08510	COG0778	Nitroreductase
SPP_RS08515	COG1484	DNA-dependent DNA replication
SPP_RS08530	COG1725	Transcriptional regulator
SPP_RS08535	COG1131	(ABC) transporter
SPP_RS08545	COG1668	transmembrane transport
SPP_RS08550	COG4152	abc transporter atp-binding protein
SPP_RS08570	COG1940	carbohydrate kinase activity
SPP_RS08575	COG2190	(PTS) system
SPP_RS08575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPP_RS08575	COG1263	PTS System
SPP_RS08585	COG1621	beta-fructofuranosidase activity
SPP_RS08590	COG1609	Transcriptional regulator
SPP_RS08600	COG3425	synthase
SPP_RS08630	COG2815	serine threonine protein kinase
SPP_RS08630	COG0515	serine threonine protein kinase
SPP_RS08635	COG0631	protein serine/threonine phosphatase activity
SPP_RS08640	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPP_RS08640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPP_RS08650	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPP_RS08660	COG0194	GDP metabolic process
SPP_RS08680	COG2226	methyltransferase
SPP_RS08685	COG0799	negative regulation of ribosome biogenesis
SPP_RS08695	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPP_RS08700	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SPP_RS08705	COG1534	Rna-binding protein
SPP_RS08710	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPP_RS08725	COG0668	transmembrane transport
SPP_RS08750	COG3118	belongs to the thioredoxin family
SPP_RS08755	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SPP_RS08760	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPP_RS08775	COG1131	(ABC) transporter
SPP_RS08780	COG0640	Transcriptional regulator
SPP_RS08785	COG1164	Oligoendopeptidase f
SPP_RS08790	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPP_RS08800	COG1051	belongs to the nudix hydrolase family
SPP_RS08835	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPP_RS08845	COG1621	beta-fructofuranosidase activity
SPP_RS08850	COG0395	ABC-type sugar transport system, permease component
SPP_RS08855	COG1175	transmembrane transport
SPP_RS08865	COG1609	Transcriptional regulator
SPP_RS08870	COG3711	transcriptional antiterminator
SPP_RS08895	COG3237	CsbD-like
SPP_RS08910	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPP_RS08915	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPP_RS08925	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPP_RS08935	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPP_RS08940	COG1846	Transcriptional regulator
SPP_RS08940	COG1940	carbohydrate kinase activity
SPP_RS08950	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SPP_RS08990	COG0512	Glutamine amidotransferase of anthranilate synthase
SPP_RS08995	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPP_RS09020	COG1285	pathogenesis
SPP_RS09025	COG1178	ABC-type Fe3 transport system permease component
SPP_RS09050	COG5434	Belongs to the glycosyl hydrolase 28 family
SPP_RS09065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SPP_RS09070	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPP_RS09075	COG1132	(ABC) transporter
SPP_RS09080	COG1132	(ABC) transporter
SPP_RS09105	COG0708	Exodeoxyribonuclease III
SPP_RS09125	COG2233	PERMEase
SPP_RS09155	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPP_RS09160	COG1609	Transcriptional regulator
SPP_RS09165	COG1063	alcohol dehydrogenase
SPP_RS09170	COG0789	Transcriptional regulator
SPP_RS09175	COG1230	cation diffusion facilitator family transporter
SPP_RS09185	COG3201	nicotinamide mononucleotide transporter
SPP_RS09195	COG1174	glycine betaine transport
SPP_RS09220	COG1363	Peptidase, m42
SPP_RS09235	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPP_RS09240	COG4605	iron ion homeostasis
SPP_RS09245	COG4604	ABC transporter, ATP-binding protein
SPP_RS09250	COG4607	ABC-type enterochelin transport system periplasmic component
SPP_RS09260	COG1187	pseudouridine synthase activity
SPP_RS09280	COG0517	IMP dehydrogenase activity
SPP_RS09290	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SPP_RS09305	COG0366	Alpha amylase catalytic
SPP_RS09310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPP_RS09310	COG1263	PTS System
SPP_RS09315	COG2188	Transcriptional regulator
SPP_RS09320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPP_RS09335	COG4608	Belongs to the ABC transporter superfamily
SPP_RS09340	COG0444	Belongs to the ABC transporter superfamily
SPP_RS09345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPP_RS09350	COG0601	transmembrane transport
SPP_RS09355	COG4166	transmembrane transport
SPP_RS09365	COG0366	Alpha amylase catalytic
SPP_RS09375	COG0395	ABC-type sugar transport system, permease component
SPP_RS09380	COG1175	transmembrane transport
SPP_RS09385	COG1653	transport
SPP_RS09390	COG3345	alpha-galactosidase
SPP_RS09395	COG2207	Transcriptional regulator
SPP_RS09400	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPP_RS09400	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPP_RS09515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPP_RS09520	COG3231	kanamycin kinase activity
SPP_RS09555	COG4221	oxidoreductase activity
SPP_RS09560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPP_RS09565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPP_RS09600	COG1132	(ABC) transporter
SPP_RS09695	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPP_RS09695	COG5263	repeat protein
SPP_RS09715	COG1316	TRANSCRIPTIONal
SPP_RS09725	COG0802	atpase or kinase
SPP_RS09750	COG1136	(ABC) transporter
SPP_RS09780	COG1253	flavin adenine dinucleotide binding
SPP_RS09795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPP_RS09800	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPP_RS09810	COG0742	ribosomal rna small subunit methyltransferase
SPP_RS09825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPP_RS09830	COG1254	Belongs to the acylphosphatase family
SPP_RS09840	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPP_RS09850	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPP_RS09865	COG1564	THIamine pyrophosphokinase
SPP_RS09875	COG1162	GTPase activity
SPP_RS09920	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SPP_RS09925	COG0084	hydrolase, TatD family'
SPP_RS09940	COG0436	Aminotransferase
SPP_RS09950	COG0589	response to stress
SPP_RS09955	COG0561	phosphatase activity
SPP_RS09960	COG0252	asparaginase activity
SPP_RS09970	COG1609	Transcriptional regulator
SPP_RS09975	COG2197	response regulator
SPP_RS09980	COG4585	Histidine kinase
SPP_RS09985	COG0842	Transport permease protein
SPP_RS09990	COG1131	(ABC) transporter
SPP_RS10090	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPP_RS10095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPP_RS10100	COG0564	pseudouridine synthase activity
SPP_RS10110	COG0577	efflux transmembrane transporter activity
SPP_RS10125	COG0157	Belongs to the NadC ModD family
SPP_RS10135	COG4133	protoheme IX ABC transporter activity
SPP_RS10140	COG2188	Transcriptional regulator
SPP_RS10145	COG2723	6-phospho-beta-galactosidase activity
SPP_RS10150	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPP_RS10160	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPP_RS10165	COG1454	alcohol dehydrogenase
SPP_RS10165	COG1012	belongs to the aldehyde dehydrogenase family
SPP_RS10175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPP_RS10185	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SPP_RS10205	COG3623	hexulose-6-phosphate isomerase
SPP_RS10215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPP_RS10225	COG3037	sugar-specific permease SgaT UlaA
SPP_RS10235	COG1847	R3H domain protein
SPP_RS10240	COG0706	membrane insertase activity
SPP_RS10290	COG4537	Required for transformation and DNA binding
SPP_RS10295	COG1459	type II secretion system
SPP_RS10300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPP_RS10310	COG1063	alcohol dehydrogenase
SPP_RS10335	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SPP_RS10340	COG3759	membrane
SPP_RS10360	COG0131	Imidazoleglycerol-phosphate dehydratase
SPP_RS10360	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SPP_RS10365	COG0534	Mate efflux family protein
SPP_RS10465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SPP_RS10480	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPP_RS10485	COG1132	(ABC) transporter
SPP_RS10495	COG1132	(ABC) transporter
SPP_RS10505	COG1438	arginine binding
SPP_RS10525	COG0745	RESPONSE REGULATOR receiver
SPP_RS10530	COG5002	protein histidine kinase activity
SPP_RS10535	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPP_RS10540	COG0573	inorganic phosphate transmembrane transporter activity
SPP_RS10550	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPP_RS10555	COG0704	Plays a role in the regulation of phosphate uptake
SPP_RS10575	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPP_RS10590	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPP_RS10605	COG0697	spore germination
SPP_RS10610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPP_RS10610	COG4499	WXG100 protein secretion system (Wss), protein YukC
SPP_RS10620	COG2217	Heavy metal translocating P-type atpase
SPP_RS10630	COG2226	methyltransferase
SPP_RS10650	COG0058	SHG alpha-glucan phosphorylase activity
SPP_RS10655	COG1640	4-alpha-glucanotransferase
SPP_RS10660	COG2182	Extracellular solute-binding protein
SPP_RS10665	COG1175	transmembrane transport
SPP_RS10670	COG3833	ABC-type maltose transport systems, permease component
SPP_RS10675	COG5521	maltodextrose utilization protein MalA
SPP_RS10680	COG1609	Transcriptional regulator
SPP_RS10695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPP_RS10730	COG1476	TRANSCRIPTIONal
SPP_RS10760	COG2151	metal-sulfur cluster biosynthetic enzyme
SPP_RS10775	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPP_RS10780	COG3959	Transketolase, thiamine diphosphate binding domain
SPP_RS10795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPP_RS10815	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPP_RS10830	COG0383	alpha-mannosidase activity
SPP_RS10840	COG3537	Alpha-1,2-mannosidase
SPP_RS10860	COG0549	Belongs to the carbamate kinase family
SPP_RS10865	COG1288	antiporter activity
SPP_RS10870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPP_RS10890	COG1454	alcohol dehydrogenase
SPP_RS10910	COG3716	PTS system mannose fructose sorbose family IID component
SPP_RS10920	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPP_RS10940	COG1070	Carbohydrate kinase
SPP_RS10950	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPP_RS10950	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPP_RS10955	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPP_RS10960	COG1121	(ABC) transporter
SPP_RS10965	COG1846	Transcriptional regulator
SPP_RS10970	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPP_RS10980	COG1696	Membrane protein involved in D-alanine export
SPP_RS10995	COG2211	Major facilitator Superfamily
SPP_RS11000	COG3344	reverse transcriptase
SPP_RS11020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPP_RS11025	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SPP_RS11045	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPP_RS11055	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPP_RS11060	COG5002	protein histidine kinase activity
SPP_RS11065	COG0745	RESPONSE REGULATOR receiver
SPP_RS11075	COG0542	response to heat
SPP_RS11080	COG4463	regulation of RNA biosynthetic process
SPP_RS11085	COG1116	anion transmembrane transporter activity
SPP_RS11090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SPP_RS11095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SPP_RS11115	COG0305	Participates in initiation and elongation during chromosome replication
SPP_RS11135	COG1040	competence protein
SPP_RS11140	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPP_RS11145	COG1739	Uncharacterized protein family UPF0029
SPP_RS11160	COG3335	DDE superfamily endonuclease
SPP_RS11180	COG3942	CHAP domain
SPP_RS11190	COG1792	Involved in formation and maintenance of cell shape
SPP_RS11195	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPP_RS11200	COG1122	ATPase activity
SPP_RS11205	COG1122	ATPase activity
SPP_RS11210	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPP_RS11220	COG0612	Peptidase, M16
SPP_RS11225	COG0612	Peptidase, M16
SPP_RS11230	COG2501	S4 domain
SPP_RS11240	COG0516	GMP reductase activity
SPP_RS11240	COG0517	IMP dehydrogenase activity
SPP_RS11245	COG0180	Tryptophanyl-tRNA synthetase
SPP_RS11250	COG0488	(ABC) transporter
SPP_RS11260	COG1511	domain protein
SPP_RS11270	COG1511	domain protein
SPP_RS11315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPP_RS11320	COG1475	DNA binding