locus-tag	class	description
spr0002	COG0592	DNA-directed DNA polymerase activity
spr0004	COG0012	GTP binding
spr0005	COG0193	aminoacyl-tRNA hydrolase activity
spr0006	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
spr0007	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
spr0010	COG0037	tRNA processing
spr0011	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
spr0012	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
spr0016	COG3335	DDE superfamily endonuclease
spr0023	COG0756	dUTP diphosphatase activity
spr0025	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
spr0028	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
spr0032	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
spr0032	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
spr0033	COG1832	CoA-binding protein
spr0034	COG2855	membrane
spr0035	COG0436	Aminotransferase
spr0036	COG1381	Involved in DNA repair and RecF pathway recombination
spr0038	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
spr0043	COG2274	protein secretion by the type I secretion system
spr0044	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
spr0045	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
spr0046	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
spr0047	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
spr0048	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
spr0049	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
spr0051	COG0138	bifunctional purine biosynthesis protein purh
spr0052	COG0151	Belongs to the GarS family
spr0053	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
spr0056	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
spr0057	COG3583	domain protein
spr0057	COG3064	Membrane
spr0057	COG3525	Glycosyl hydrolase, family 20, catalytic domain
spr0060	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
spr0061	COG3715	PTS system
spr0062	COG3716	PTS system mannose fructose sorbose family IID component
spr0064	COG2222	sugar isomerase
spr0066	COG2514	catechol 2,3-dioxygenase activity
spr0067	COG1937	Protein conserved in bacteria
spr0070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
spr0071	COG0569	domain protein
spr0077	COG5002	protein histidine kinase activity
spr0081	COG4209	transmembrane transport
spr0082	COG0395	ABC-type sugar transport system, permease component
spr0083	COG1653	transport
spr0089	COG1695	Transcriptional regulator
spr0093	COG0546	phosphoglycolate phosphatase activity
spr0094	COG1760	l-serine dehydratase
spr0095	COG1760	l-serine dehydratase
spr0101	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
spr0102	COG0137	argininosuccinate synthase activity
spr0106	COG2274	protein secretion by the type I secretion system
spr0122	COG0482	sulfurtransferase activity
spr0123	COG0494	nUDIX hydrolase
spr0124	COG0445	tRNA wobble uridine modification
spr0129	COG1214	PFAM Peptidase M22, glycoprotease
spr0131	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
spr0135	COG0438	transferase activity, transferring glycosyl groups
spr0140	COG1396	sequence-specific DNA binding
spr0146	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
spr0147	COG1464	Belongs to the NlpA lipoprotein family
spr0148	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
spr0149	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
spr0153	COG2972	Histidine kinase
spr0154	COG2207	Transcriptional regulator
spr0154	COG4753	response regulator
spr0156	COG1780	Probably involved in ribonucleotide reductase function
spr0162	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
spr0162	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
spr0166	COG2818	Glycosylase
spr0171	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
spr0172	COG0006	proline dipeptidase activity
spr0173	COG1393	Belongs to the ArsC family
spr0178	COG0285	dihydrofolate synthase activity
spr0180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
spr0185	COG0602	queuosine metabolic process
spr0192	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
spr0198	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
spr0206	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
spr0209	COG0201	protein transport
spr0211	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
spr0212	COG0257	Belongs to the bacterial ribosomal protein bL36 family
spr0214	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
spr0215	COG0202	RNA polymerase activity
spr0217	COG3830	Belongs to the UPF0237 family
spr0221	COG1178	ABC-type Fe3 transport system permease component
spr0222	COG3842	ATPase activity
spr0226	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
spr0227	COG1349	DNA-binding transcription factor activity
spr0229	COG1447	Phosphotransferase system cellobiose-specific component IIA
spr0230	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
spr0231	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
spr0232	COG1882	Formate acetyltransferase
spr0235	COG0495	leucyl-tRNA aminoacylation
spr0240	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
spr0241	COG4589	Belongs to the CDS family
spr0242	COG0750	zinc metalloprotease
spr0243	COG0442	prolyl-tRNA aminoacylation
spr0244	COG2723	6-phospho-beta-galactosidase activity
spr0245	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
spr0247	COG1523	belongs to the glycosyl hydrolase 13 family
spr0251	COG2176	DNA-directed DNA polymerase activity
spr0254	COG2309	aminopeptidase activity
spr0255	COG2261	transglycosylase associated protein
spr0256	COG1187	pseudouridine synthase activity
spr0258	COG3579	cysteine-type endopeptidase activity
spr0259	COG3716	PTS system mannose fructose sorbose family IID component
spr0260	COG3715	PTS system
spr0262	COG1064	alcohol dehydrogenase
spr0263	COG0561	phosphatase activity
spr0264	COG2252	PERMEase
spr0266	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
spr0267	COG0285	dihydrofolate synthase activity
spr0268	COG0302	gtp cyclohydrolase
spr0269	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
spr0269	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
spr0271	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
spr0276	COG2723	6-phospho-beta-galactosidase activity
spr0279	COG3711	transcriptional antiterminator
spr0279	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
spr0282	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
spr0285	COG0386	Belongs to the glutathione peroxidase family
spr0286	COG5492	domain, Protein
spr0290	COG1028	Short-chain dehydrogenase reductase Sdr
spr0292	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
spr0293	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
spr0294	COG3715	PTS system
spr0295	COG3716	PTS system mannose fructose sorbose family IID component
spr0298	COG1609	Transcriptional regulator
spr0303	COG4839	cell division protein FtsL
spr0304	COG0768	penicillin binding
spr0305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
spr0309	COG4868	Belongs to the UPF0371 family
spr0310	COG0366	Alpha amylase catalytic
spr0311	COG4166	transmembrane transport
spr0318	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
spr0319	COG0562	UDP-galactopyranose mutase
spr0320	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
spr0322	COG1088	dTDP-glucose 4,6-dehydratase activity
spr0323	COG1091	dTDP-4-dehydrorhamnose reductase activity
spr0325	COG4372	Transposase
spr0327	COG4166	transmembrane transport
spr0328	COG0366	Alpha amylase catalytic
spr0329	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
spr0333	COG0116	Belongs to the methyltransferase superfamily
spr0335	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
spr0336	COG0745	RESPONSE REGULATOR receiver
spr0341	COG1304	FMN binding
spr0343	COG4585	Histidine kinase
spr0344	COG2197	response regulator
spr0356	COG2213	PTS system mannitol-specific
spr0357	COG3711	transcriptional antiterminator
spr0358	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
spr0359	COG0246	Mannitol dehydrogenase
spr0362	COG0544	peptidyl-prolyl cis-trans isomerase activity
spr0363	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
spr0364	COG0681	Belongs to the peptidase S26 family
spr0368	COG1193	negative regulation of DNA recombination
spr0369	COG1115	amino acid carrier protein
spr0372	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
spr0374	COG0527	aspartate kinase activity
spr0375	COG1024	Enoyl-CoA hydratase
spr0376	COG1846	Transcriptional regulator
spr0378	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
spr0380	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
spr0381	COG1028	Short-chain dehydrogenase reductase Sdr
spr0382	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
spr0385	COG0439	Biotin carboxylase
spr0386	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
spr0393	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
spr0397	COG1442	glycosyl transferase family 8
spr0398	COG0227	Belongs to the bacterial ribosomal protein bL28 family
spr0400	COG1461	Dihydroxyacetone kinase
spr0401	COG0028	Belongs to the TPP enzyme family
spr0402	COG0440	acetolactate synthase activity
spr0406	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
spr0409	COG0765	amino acid transport
spr0414	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
spr0415	COG1882	Formate acetyltransferase
spr0420	COG1846	Transcriptional regulator
spr0420	COG1940	carbohydrate kinase activity
spr0421	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
spr0423	COG1447	Phosphotransferase system cellobiose-specific component IIA
spr0424	COG2723	6-phospho-beta-galactosidase activity
spr0425	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
spr0425	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
spr0426	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
spr0427	COG0569	domain protein
spr0430	COG1122	ATPase activity
spr0433	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
spr0434	COG0671	phosphoesterase, PA-phosphatase related
spr0436	COG1247	-acetyltransferase
spr0438	COG0504	CTP synthase activity
spr0439	COG1283	sodium-dependent phosphate transmembrane transporter activity
spr0441	COG0126	phosphoglycerate kinase activity
spr0443	COG0789	Transcriptional regulator
spr0444	COG0174	glutamine synthetase
spr0445	COG0732	type I restriction modification DNA specificity domain
spr0447	COG4974	Belongs to the 'phage' integrase family
spr0454	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
spr0456	COG0484	heat shock protein binding
spr0458	COG0537	adenosine 5'-monophosphoramidase activity
spr0459	COG1131	(ABC) transporter
spr0464	COG3290	protein histidine kinase activity
spr0474	COG1266	CAAX protease self-immunity
spr0478	COG0195	Participates in both transcription termination and antitermination
spr0479	COG2740	Nucleic-acid-binding protein implicated in transcription termination
spr0482	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
spr0490	COG0519	Catalyzes the synthesis of GMP from XMP
spr0492	COG0525	valine-tRNA ligase activity
spr0504	COG3711	transcriptional antiterminator
spr0505	COG2190	(PTS) system
spr0505	COG1263	PTS System
spr0505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
spr0508	COG0456	acetyltransferase
spr0509	COG0072	phenylalanine-tRNA ligase activity
spr0509	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
spr0513	COG3620	sequence-specific DNA binding
spr0514	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
spr0516	COG1185	polyribonucleotide nucleotidyltransferase activity
spr0517	COG1045	serine acetyltransferase
spr0519	COG0215	cysteine-tRNA ligase activity
spr0520	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
spr0524	COG0577	efflux transmembrane transporter activity
spr0525	COG1136	(ABC) transporter
spr0526	COG0577	efflux transmembrane transporter activity
spr0528	COG0745	RESPONSE REGULATOR receiver
spr0529	COG5002	protein histidine kinase activity
spr0530	COG0191	fructose-bisphosphate aldolase activity
spr0531	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
spr0532	COG0765	amino acid transport
spr0533	COG0765	amino acid transport
spr0534	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
spr0537	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
spr0537	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
spr0543	COG0322	excinuclease ABC activity
spr0545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
spr0548	COG1573	uracil-dna glycosylase
spr0551	COG1114	Component of the transport system for branched-chain amino acids
spr0552	COG1363	Peptidase, m42
spr0557	COG4555	ABC transporter
spr0561	COG1404	Belongs to the peptidase S8 family
spr0564	COG3775	system Galactitol-specific IIC component
spr0565	COG3250	beta-galactosidase activity
spr0569	COG1242	4 iron, 4 sulfur cluster binding
spr0570	COG1242	4 iron, 4 sulfur cluster binding
spr0571	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
spr0575	COG0785	Cytochrome C biogenesis protein
spr0576	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
spr0577	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
spr0577	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
spr0578	COG4753	response regulator
spr0578	COG2207	Transcriptional regulator
spr0579	COG2972	Histidine kinase
spr0580	COG4475	Protein of unknown function (DUF436)
spr0581	COG3064	Membrane
spr0582	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
spr0584	COG1940	carbohydrate kinase activity
spr0588	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
spr0589	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
spr0590	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
spr0592	COG0300	oxidoreductase activity
spr0595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
spr0597	COG1187	pseudouridine synthase activity
spr0598	COG1217	gtp-binding protein TYPA
spr0602	COG1136	(ABC) transporter
spr0603	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
spr0604	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
spr0605	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
spr0614	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
spr0619	COG1131	(ABC) transporter
spr0622	COG1126	abc transporter atp-binding protein
spr0623	COG0765	amino acid transport
spr0627	COG1304	FMN binding
spr0629	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
spr0630	COG0352	thiamine-phosphate diphosphorylase activity
spr0632	COG4172	Belongs to the ABC transporter superfamily
spr0634	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
spr0636	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
spr0637	COG0352	thiamine-phosphate diphosphorylase activity
spr0641	COG2217	Heavy metal translocating P-type atpase
spr0642	COG0028	Belongs to the TPP enzyme family
spr0644	COG3335	DDE superfamily endonuclease
spr0647	COG1482	cell wall glycoprotein biosynthetic process
spr0648	COG0733	neurotransmitter:sodium symporter activity
spr0649	COG0789	Transcriptional regulator
spr0651	COG2081	HI0933 family
spr0652	COG1307	EDD domain protein, DegV family
spr0654	COG2131	deaminase
spr0655	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
spr0664	COG0617	tRNA 3'-terminal CCA addition
spr0664	COG0517	IMP dehydrogenase activity
spr0664	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
spr0665	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
spr0666	COG2884	Cell division ATP-binding protein ftsE
spr0667	COG2177	Part of the ABC transporter FtsEX involved in
spr0668	COG2190	(PTS) system
spr0668	COG1263	PTS System
spr0668	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
spr0670	COG0513	Belongs to the DEAD box helicase family
spr0672	COG0167	dihydroorotate dehydrogenase activity
spr0674	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
spr0675	COG4470	Protein conserved in bacteria
spr0676	COG0820	rRNA (adenine-C2-)-methyltransferase activity
spr0678	COG0488	(ABC) transporter
spr0683	COG1837	Belongs to the UPF0109 family
spr0688	COG1328	CTP reductase activity
spr0688	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
spr0690	COG4443	Transcriptional Coactivator p15 (PC4)
spr0691	COG1268	BioY protein
spr0692	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
spr0693	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
spr0694	COG1136	(ABC) transporter
spr0695	COG0577	efflux transmembrane transporter activity
spr0696	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
spr0696	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
spr0699	COG4989	oxidoreductase activity
spr0701	COG1028	Short-chain dehydrogenase reductase Sdr
spr0707	COG0745	RESPONSE REGULATOR receiver
spr0708	COG5002	protein histidine kinase activity
spr0712	COG0772	Belongs to the SEDS family
spr0713	COG0693	protein deglycase activity
spr0715	COG0187	DNA topoisomerase II activity
spr0718	COG3335	DDE superfamily endonuclease
spr0721	COG0494	nUDIX hydrolase
spr0725	COG0542	response to heat
spr0726	COG4703	Protein of unknown function (DUF1797)
spr0727	COG0765	amino acid transport
spr0728	COG1126	abc transporter atp-binding protein
spr0729	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
spr0730	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
spr0732	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
spr0734	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
spr0743	COG2813	Specifically methylates the guanine in position
spr0744	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
spr0745	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
spr0746	COG0295	cytidine deaminase activity
spr0747	COG1744	ABC transporter substrate-binding protein PnrA-like
spr0748	COG3845	ABC transporter
spr0749	COG4603	Belongs to the binding-protein-dependent transport system permease family
spr0750	COG1079	Belongs to the binding-protein-dependent transport system permease family
spr0756	COG0187	DNA topoisomerase II activity
spr0757	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
spr0758	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
spr0764	COG0539	negative regulation of cytoplasmic translation
spr0768	COG1956	GAF domain-containing protein
spr0769	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
spr0772	COG0719	Fe-S assembly protein
spr0773	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
spr0775	COG0719	Fe-S assembly protein
spr0776	COG1686	Belongs to the peptidase S11 family
spr0777	COG0628	permease
spr0778	COG1349	DNA-binding transcription factor activity
spr0779	COG1105	Belongs to the carbohydrate kinase PfkB family
spr0780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
spr0780	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
spr0780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
spr0781	COG0697	spore germination
spr0781	COG1674	ftsk spoiiie
spr0783	COG1104	cysteine desulfurase activity
spr0784	COG0301	tRNA thio-modification
spr0792	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
spr0793	COG1438	arginine binding
spr0794	COG2936	dipeptidyl-peptidase activity
spr0796	COG0205	6-phosphofructokinase activity
spr0797	COG0469	pyruvate kinase activity
spr0804	COG3689	TIGRFAM TIGR03943 family protein
spr0805	COG0701	Predicted permease
spr0808	COG2183	response to ionizing radiation
spr0812	COG1136	(ABC) transporter
spr0813	COG0577	efflux transmembrane transporter activity
spr0816	COG1982	Orn Lys Arg decarboxylase major
spr0819	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
spr0822	COG2957	Belongs to the agmatine deiminase family
spr0823	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
spr0824	COG0561	phosphatase activity
spr0828	COG0583	DNA-binding transcription factor activity
spr0829	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
spr0830	COG0564	pseudouridine synthase activity
spr0831	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
spr0832	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
spr0834	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
spr0835	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
spr0836	COG0470	DNA polymerase III
spr0845	COG0528	UMP kinase activity
spr0846	COG0233	cytoplasmic translational termination
spr0847	COG2996	Protein conserved in bacteria
spr0849	COG1702	phosphate starvation-inducible protein PhoH
spr0855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
spr0856	COG1596	polysaccharide export
spr0856	COG1555	photosystem II stabilization
spr0857	COG2333	competence protein COMEC
spr0857	COG0658	competence protein
spr0865	COG0543	2 iron, 2 sulfur cluster binding
spr0866	COG0167	dihydroorotate dehydrogenase activity
spr0867	COG5263	repeat protein
spr0867	COG4193	domain, Protein
spr0868	COG1293	RNA-binding protein homologous to eukaryotic snRNP
spr0870	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
spr0872	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
spr0873	COG0237	dephospho-CoA kinase activity
spr0875	COG2814	Major facilitator Superfamily
spr0878	COG0557	exoribonuclease II activity
spr0880	COG3615	Tellurite resistance protein tehB
spr0880	COG0500	methyltransferase
spr0883	COG4122	O-methyltransferase activity
spr0888	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
spr0891	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
spr0892	COG0494	nUDIX hydrolase
spr0894	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
spr0896	COG2176	DNA-directed DNA polymerase activity
spr0897	COG0584	glycerophosphoryl diester phosphodiesterase
spr0903	COG0785	Cytochrome C biogenesis protein
spr0904	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
spr0905	COG0531	amino acid
spr0906	COG0803	Belongs to the bacterial solute-binding protein 9 family
spr0906	COG3443	Belongs to the bacterial solute-binding protein 9 family
spr0913	COG2195	Cleaves the N-terminal amino acid of tripeptides
spr0914	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
spr0915	COG1970	mechanosensitive ion channel activity
spr0917	COG4708	membrane
spr0918	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
spr0919	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
spr0920	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
spr0921	COG1942	4-Oxalocrotonate Tautomerase
spr0922	COG1435	thymidine kinase activity
spr0925	COG2890	protein-(glutamine-N5) methyltransferase activity
spr0928	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
spr0930	COG0741	lytic transglycosylase activity
spr0932	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
spr0935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
spr0936	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
spr0947	COG1597	lipid kinase activity
spr0948	COG0366	Alpha amylase catalytic
spr0951	COG1396	sequence-specific DNA binding
spr0952	COG0542	response to heat
spr0966	COG0318	PFAM AMP-dependent synthetase and ligase
spr0973	COG0772	Belongs to the SEDS family
spr0974	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
spr0978	COG0358	DNA primase activity
spr0979	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
spr0980	COG2151	metal-sulfur cluster biosynthetic enzyme
spr0981	COG0438	transferase activity, transferring glycosyl groups
spr0982	COG0438	transferase activity, transferring glycosyl groups
spr0984	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
spr0989	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
spr0991	COG4109	DRTGG domain
spr0992	COG0024	Methionine aminopeptidase
spr0995	COG0210	DNA helicase
spr0996	COG2003	Belongs to the UPF0758 family
spr0997	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
spr0998	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
spr1001	COG1104	cysteine desulfurase activity
spr1002	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
spr1004	COG2357	RelA SpoT domain protein
spr1006	COG0564	pseudouridine synthase activity
spr1007	COG0280	phosphate acetyltransferase
spr1014	COG0211	Belongs to the bacterial ribosomal protein bL27 family
spr1017	COG0196	riboflavin kinase activity
spr1018	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
spr1019	COG1307	EDD domain protein, DegV family
spr1021	COG0488	(ABC) transporter
spr1024	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
spr1025	COG1523	belongs to the glycosyl hydrolase 13 family
spr1028	COG1012	belongs to the aldehyde dehydrogenase family
spr1029	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
spr1030	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
spr1031	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
spr1032	COG0297	glycogen (starch) synthase activity
spr1039	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
spr1040	COG1074	ATP-dependent DNA helicase activity
spr1042	COG3583	domain protein
spr1042	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
spr1043	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
spr1044	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
spr1047	COG0095	Lipoate-protein ligase
spr1048	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
spr1049	COG0508	dehydrogenase complex catalyzes the overall conversion of
spr1050	COG0022	dehydrogenase e1 component
spr1051	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
spr1052	COG0534	Mate efflux family protein
spr1053	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
spr1054	COG1051	belongs to the nudix hydrolase family
spr1057	COG1011	Hydrolase
spr1063	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
spr1064	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
spr1065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
spr1066	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
spr1069	COG2723	6-phospho-beta-galactosidase activity
spr1072	COG3711	transcriptional antiterminator
spr1073	COG3684	Belongs to the aldolase LacD family
spr1083	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
spr1084	COG0497	DNA recombination
spr1085	COG1438	arginine binding
spr1086	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
spr1089	COG1570	exodeoxyribonuclease VII activity
spr1092	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
spr1098	COG3764	Sortase (surface protein transpeptidase)
spr1099	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
spr1105	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
spr1106	COG5002	protein histidine kinase activity
spr1107	COG0745	RESPONSE REGULATOR receiver
spr1108	COG1194	a g-specific adenine glycosylase
spr1111	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
spr1112	COG4684	Psort location CytoplasmicMembrane, score
spr1114	COG1827	regulation of RNA biosynthetic process
spr1118	COG0556	nucleotide-excision repair
spr1120	COG0765	amino acid transport
spr1121	COG1126	abc transporter atp-binding protein
spr1122	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
spr1123	COG0552	protein localization to endoplasmic reticulum
spr1124	COG0561	phosphatase activity
spr1125	COG0561	phosphatase activity
spr1126	COG1196	nuclear chromosome segregation
spr1130	COG1401	restriction endodeoxyribonuclease activity
spr1135	COG0473	3-isopropylmalate dehydrogenase activity
spr1139	COG3142	Participates in the control of copper homeostasis
spr1140	COG2832	Protein of unknown function (DUF454)
spr1141	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
spr1144	COG0758	DNA mediated transformation
spr1145	COG4750	Nucleotidyl transferase
spr1148	COG1063	alcohol dehydrogenase
spr1149	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
spr1151	COG3475	LICD family
spr1152	COG3475	LICD family
spr1153	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
spr1154	COG0505	Belongs to the CarA family
spr1155	COG0540	Belongs to the ATCase OTCase family
spr1157	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
spr1161	COG0488	(ABC) transporter
spr1163	COG1704	LemA family
spr1166	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
spr1169	COG1078	dGTPase activity
spr1171	COG0335	large ribosomal subunit rRNA binding
spr1172	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
spr1173	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
spr1174	COG0077	Prephenate dehydratase
spr1174	COG1605	Chorismate mutase
spr1175	COG0716	FMN binding
spr1176	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
spr1179	COG2837	iron assimilation
spr1181	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
spr1188	COG0295	cytidine deaminase activity
spr1189	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
spr1192	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
spr1193	COG0601	transmembrane transport
spr1196	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
spr1202	COG1136	(ABC) transporter
spr1202	COG0577	efflux transmembrane transporter activity
spr1204	COG1770	oligopeptidase
spr1205	COG0515	serine threonine protein kinase
spr1214	COG0402	S-adenosylhomocysteine deaminase activity
spr1217	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
spr1217	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
spr1220	COG4862	establishment of competence for transformation
spr1223	COG1215	transferase activity, transferring glycosyl groups
spr1225	COG3475	LICD family
spr1227	COG0077	Prephenate dehydratase
spr1228	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
spr1229	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
spr1231	COG0287	Prephenate dehydrogenase
spr1236	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
spr1238	COG1131	(ABC) transporter
spr1240	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
spr1246	COG3842	ATPase activity
spr1249	COG3527	Alpha-acetolactate decarboxylase
spr1250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
spr1251	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
spr1252	COG0704	Plays a role in the regulation of phosphate uptake
spr1253	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
spr1254	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
spr1255	COG0581	inorganic phosphate transmembrane transporter activity
spr1256	COG0573	inorganic phosphate transmembrane transporter activity
spr1257	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
spr1260	COG0483	inositol monophosphate 1-phosphatase activity
spr1262	COG1393	Belongs to the ArsC family
spr1264	COG0647	UMP catabolic process
spr1266	COG0635	Involved in the biosynthesis of porphyrin-containing compound
spr1270	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
spr1273	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
spr1275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
spr1277	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
spr1281	COG1131	(ABC) transporter
spr1282	COG0826	peptidase U32
spr1284	COG0826	peptidase U32
spr1290	COG1132	(ABC) transporter
spr1293	COG1129	ABC transporter
spr1301	COG2188	Transcriptional regulator
spr1302	COG0697	spore germination
spr1303	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
spr1306	COG0561	phosphatase activity
spr1312	COG0492	ferredoxin-NADP+ reductase activity
spr1314	COG1126	abc transporter atp-binding protein
spr1316	COG1393	Belongs to the ArsC family
spr1317	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
spr1320	COG1272	protein, Hemolysin III
spr1321	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
spr1326	COG0431	NADPH-dependent FMN reductase
spr1326	COG1053	succinate dehydrogenase
spr1326	COG3976	FMN-binding domain protein
spr1328	COG0751	glycine-tRNA ligase activity
spr1329	COG0752	glycyl-tRNA synthetase alpha subunit
spr1332	COG0656	L-ascorbic acid biosynthetic process
spr1333	COG0726	polysaccharide deacetylase
spr1344	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
spr1351	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
spr1353	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
spr1354	COG1126	abc transporter atp-binding protein
spr1357	COG0628	permease
spr1358	COG2706	6-phosphogluconolactonase activity
spr1361	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
spr1370	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
spr1375	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
spr1376	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
spr1377	COG0626	cystathionine gamma-synthase activity
spr1382	COG4166	transmembrane transport
spr1383	COG2244	polysaccharide biosynthetic process
spr1384	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
spr1390	COG2827	Endonuclease containing a URI domain
spr1391	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
spr1392	COG1098	S1 RNA binding domain
spr1394	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
spr1395	COG0629	single-stranded DNA binding
spr1397	COG0017	Asparaginyl-tRNA synthetase
spr1399	COG0436	Aminotransferase
spr1404	COG3711	transcriptional antiterminator
spr1408	COG0242	peptide deformylase activity
spr1409	COG0625	glutathione transferase activity
spr1411	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
spr1412	COG0488	(ABC) transporter
spr1413	COG0617	tRNA 3'-terminal CCA addition
spr1415	COG1307	EDD domain protein, DegV family
spr1417	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
spr1419	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
spr1421	COG0492	ferredoxin-NADP+ reductase activity
spr1422	COG1481	regulation of sporulation
spr1423	COG0391	Required for morphogenesis under gluconeogenic growth conditions
spr1424	COG1660	Displays ATPase and GTPase activities
spr1425	COG0251	oxidation-reduction process
spr1429	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
spr1431	COG5263	repeat protein
spr1431	COG4193	domain, Protein
spr1433	COG3935	DnaD domain protein
spr1436	COG2226	methyltransferase
spr1437	COG3842	ATPase activity
spr1438	COG1335	isochorismatase
spr1439	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
spr1440	COG0513	Belongs to the DEAD box helicase family
spr1441	COG2223	nitrite transmembrane transporter activity
spr1442	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
spr1443	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
spr1444	COG3442	glutamine amidotransferase
spr1445	COG0006	proline dipeptidase activity
spr1446	COG2801	Transposase and inactivated derivatives
spr1447	COG2801	Transposase and inactivated derivatives
spr1449	COG4720	Psort location CytoplasmicMembrane, score
spr1450	COG0351	phosphomethylpyrimidine kinase
spr1455	COG2824	Alkylphosphonate utilization operon protein PhnA
spr1459	COG0463	Glycosyl transferase, family 2
spr1460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
spr1461	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
spr1462	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
spr1463	COG2384	SAM-dependent methyltransferase
spr1464	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
spr1465	COG0204	Acyl-transferase
spr1468	COG2910	NAD(P)H-binding
spr1472	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
spr1473	COG5002	protein histidine kinase activity
spr1474	COG0745	RESPONSE REGULATOR receiver
spr1477	COG1959	2 iron, 2 sulfur cluster binding
spr1491	COG3590	peptidase
spr1494	COG0803	Belongs to the bacterial solute-binding protein 9 family
spr1495	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
spr1497	COG1136	(ABC) transporter
spr1497	COG0577	efflux transmembrane transporter activity
spr1502	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
spr1505	COG3599	regulation of cell shape
spr1509	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
spr1513	COG1051	belongs to the nudix hydrolase family
spr1514	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
spr1515	COG1181	Belongs to the D-alanine--D-alanine ligase family
spr1517	COG0768	penicillin binding
spr1524	COG2731	YhcH YjgK YiaL family protein
spr1525	COG0395	ABC-type sugar transport system, permease component
spr1526	COG1175	transmembrane transport
spr1528	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
spr1528	COG1263	PTS System
spr1528	COG2190	(PTS) system
spr1530	COG0673	inositol 2-dehydrogenase activity
spr1531	COG4409	exo-alpha-(2->6)-sialidase activity
spr1533	COG1175	transmembrane transport
spr1534	COG1653	transport
spr1538	COG3458	cephalosporin-C deacetylase activity
spr1539	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
spr1542	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
spr1543	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
spr1544	COG0653	protein targeting
spr1546	COG1131	(ABC) transporter
spr1555	COG1484	DNA-dependent DNA replication
spr1558	COG1725	Transcriptional regulator
spr1559	COG1131	(ABC) transporter
spr1561	COG1668	transmembrane transport
spr1562	COG4152	abc transporter atp-binding protein
spr1565	COG1940	carbohydrate kinase activity
spr1566	COG1263	PTS System
spr1566	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
spr1566	COG2190	(PTS) system
spr1568	COG1621	beta-fructofuranosidase activity
spr1569	COG1609	Transcriptional regulator
spr1571	COG3425	synthase
spr1577	COG0515	serine threonine protein kinase
spr1577	COG2815	serine threonine protein kinase
spr1578	COG0631	protein serine/threonine phosphatase activity
spr1579	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
spr1579	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
spr1581	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
spr1583	COG0194	GDP metabolic process
spr1585	COG4115	mRNA cleavage
spr1587	COG1323	Belongs to the UPF0348 family
spr1588	COG2226	methyltransferase
spr1589	COG0799	negative regulation of ribosome biogenesis
spr1591	COG1713	HD superfamily hydrolase involved in NAD metabolism
spr1592	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
spr1593	COG1534	Rna-binding protein
spr1594	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
spr1597	COG0668	transmembrane transport
spr1598	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
spr1602	COG3118	belongs to the thioredoxin family
spr1603	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
spr1604	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
spr1606	COG1164	Oligoendopeptidase f
spr1607	COG1385	rRNA (uridine-N3-)-methyltransferase activity
spr1608	COG2264	protein methyltransferase activity
spr1609	COG1051	belongs to the nudix hydrolase family
spr1616	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
spr1617	COG1621	beta-fructofuranosidase activity
spr1618	COG0395	ABC-type sugar transport system, permease component
spr1619	COG1175	transmembrane transport
spr1621	COG1609	Transcriptional regulator
spr1622	COG3711	transcriptional antiterminator
spr1626	COG3237	CsbD-like
spr1631	COG0159	tryptophan synthase activity
spr1632	COG0133	tryptophan synthase activity
spr1633	COG0135	phosphoribosylanthranilate isomerase activity
spr1636	COG0512	Glutamine amidotransferase of anthranilate synthase
spr1637	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
spr1641	COG1285	pathogenesis
spr1643	COG1178	ABC-type Fe3 transport system permease component
spr1647	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
spr1648	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
spr1649	COG0704	Plays a role in the regulation of phosphate uptake
spr1652	COG5434	Belongs to the glycosyl hydrolase 28 family
spr1654	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
spr1655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
spr1656	COG1132	(ABC) transporter
spr1657	COG1132	(ABC) transporter
spr1660	COG0708	Exodeoxyribonuclease III
spr1662	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
spr1663	COG2233	PERMEase
spr1667	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
spr1668	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
spr1669	COG1609	Transcriptional regulator
spr1670	COG1063	alcohol dehydrogenase
spr1671	COG0789	Transcriptional regulator
spr1672	COG1230	cation diffusion facilitator family transporter
spr1674	COG3201	nicotinamide mononucleotide transporter
spr1677	COG1174	glycine betaine transport
spr1682	COG1363	Peptidase, m42
spr1684	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
spr1685	COG4605	iron ion homeostasis
spr1686	COG4604	ABC transporter, ATP-binding protein
spr1687	COG4607	ABC-type enterochelin transport system periplasmic component
spr1689	COG1187	pseudouridine synthase activity
spr1693	COG0517	IMP dehydrogenase activity
spr1695	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
spr1698	COG0366	Alpha amylase catalytic
spr1699	COG1263	PTS System
spr1699	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
spr1700	COG2188	Transcriptional regulator
spr1703	COG4608	Belongs to the ABC transporter superfamily
spr1704	COG0444	Belongs to the ABC transporter superfamily
spr1705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
spr1706	COG0601	transmembrane transport
spr1707	COG4166	transmembrane transport
spr1709	COG0366	Alpha amylase catalytic
spr1710	COG0395	ABC-type sugar transport system, permease component
spr1711	COG1175	transmembrane transport
spr1712	COG1653	transport
spr1713	COG3345	alpha-galactosidase
spr1714	COG2207	Transcriptional regulator
spr1715	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
spr1715	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
spr1717	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
spr1723	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
spr1725	COG4221	oxidoreductase activity
spr1726	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
spr1727	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
spr1734	COG1132	(ABC) transporter
spr1754	COG5632	N-Acetylmuramoyl-L-alanine amidase
spr1754	COG5263	repeat protein
spr1758	COG1058	Belongs to the CinA family
spr1758	COG1546	Belongs to the CinA family
spr1759	COG1316	TRANSCRIPTIONal
spr1761	COG0802	atpase or kinase
spr1773	COG1136	(ABC) transporter
spr1776	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
spr1778	COG1253	flavin adenine dinucleotide binding
spr1781	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
spr1782	COG3480	Lon protease (S16) C-terminal proteolytic domain
spr1783	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
spr1784	COG0742	ribosomal rna small subunit methyltransferase
spr1785	COG2502	aspartate--ammonia ligase
spr1788	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
spr1789	COG1254	Belongs to the acylphosphatase family
spr1790	COG0706	membrane insertase activity
spr1791	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
spr1793	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
spr1796	COG1564	THIamine pyrophosphokinase
spr1798	COG1162	GTPase activity
spr1799	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
spr1804	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
spr1805	COG0084	hydrolase, TatD family'
spr1808	COG0436	Aminotransferase
spr1810	COG0589	response to stress
spr1811	COG0561	phosphatase activity
spr1812	COG0252	asparaginase activity
spr1813	COG1609	Transcriptional regulator
spr1814	COG2197	response regulator
spr1815	COG4585	Histidine kinase
spr1816	COG0842	Transport permease protein
spr1817	COG1131	(ABC) transporter
spr1822	COG0267	Belongs to the bacterial ribosomal protein bL33 family
spr1823	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
spr1824	COG0564	pseudouridine synthase activity
spr1826	COG0577	efflux transmembrane transporter activity
spr1829	COG0157	Belongs to the NadC ModD family
spr1831	COG1129	ABC transporter
spr1832	COG2188	Transcriptional regulator
spr1833	COG2723	6-phospho-beta-galactosidase activity
spr1834	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
spr1836	COG1447	Phosphotransferase system cellobiose-specific component IIA
spr1837	COG1454	alcohol dehydrogenase
spr1837	COG1012	belongs to the aldehyde dehydrogenase family
spr1839	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
spr1841	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
spr1845	COG3623	hexulose-6-phosphate isomerase
spr1847	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
spr1849	COG3037	sugar-specific permease SgaT UlaA
spr1851	COG1847	R3H domain protein
spr1852	COG0706	membrane insertase activity
spr1854	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
spr1862	COG4537	Required for transformation and DNA binding
spr1863	COG1459	type II secretion system
spr1864	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
spr1866	COG1063	alcohol dehydrogenase
spr1876	COG0131	Imidazoleglycerol-phosphate dehydratase
spr1876	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
spr1877	COG0534	Mate efflux family protein
spr1881	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
spr1884	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
spr1885	COG1132	(ABC) transporter
spr1887	COG1132	(ABC) transporter
spr1889	COG1438	arginine binding
spr1893	COG0745	RESPONSE REGULATOR receiver
spr1894	COG5002	protein histidine kinase activity
spr1895	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
spr1896	COG0573	inorganic phosphate transmembrane transporter activity
spr1898	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
spr1899	COG0704	Plays a role in the regulation of phosphate uptake
spr1903	COG1210	Utp--glucose-1-phosphate uridylyltransferase
spr1905	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
spr1908	COG0697	spore germination
spr1909	COG4499	WXG100 protein secretion system (Wss), protein YukC
spr1909	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
spr1911	COG2217	Heavy metal translocating P-type atpase
spr1913	COG2226	methyltransferase
spr1916	COG0058	SHG alpha-glucan phosphorylase activity
spr1917	COG1640	4-alpha-glucanotransferase
spr1918	COG2182	Extracellular solute-binding protein
spr1919	COG1175	transmembrane transport
spr1920	COG3833	ABC-type maltose transport systems, permease component
spr1921	COG5521	maltodextrose utilization protein MalA
spr1922	COG1609	Transcriptional regulator
spr1923	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
spr1924	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
spr1929	COG1476	TRANSCRIPTIONal
spr1934	COG2151	metal-sulfur cluster biosynthetic enzyme
spr1936	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
spr1937	COG3959	Transketolase, thiamine diphosphate binding domain
spr1940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
spr1944	COG0267	Belongs to the bacterial ribosomal protein bL33 family
spr1951	COG0383	alpha-mannosidase activity
spr1953	COG3537	Alpha-1,2-mannosidase
spr1958	COG0549	Belongs to the carbamate kinase family
spr1959	COG1288	antiporter activity
spr1960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
spr1963	COG1454	alcohol dehydrogenase
spr1964	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
spr1967	COG3716	PTS system mannose fructose sorbose family IID component
spr1969	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
spr1973	COG1070	Carbohydrate kinase
spr1975	COG3443	Belongs to the bacterial solute-binding protein 9 family
spr1975	COG0803	Belongs to the bacterial solute-binding protein 9 family
spr1976	COG1108	ABC-type Mn2 Zn2 transport systems permease components
spr1977	COG1121	(ABC) transporter
spr1978	COG1846	Transcriptional regulator
spr1979	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
spr1981	COG1696	Membrane protein involved in D-alanine export
spr1983	COG2211	Major facilitator Superfamily
spr1988	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
spr1994	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
spr1996	COG1755	Isoprenylcysteine carboxyl methyltransferase
spr1997	COG5002	protein histidine kinase activity
spr1998	COG0745	RESPONSE REGULATOR receiver
spr1999	COG0542	response to heat
spr2001	COG4463	regulation of RNA biosynthetic process
spr2002	COG1116	anion transmembrane transporter activity
spr2003	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
spr2004	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
spr2008	COG0305	Participates in initiation and elongation during chromosome replication
spr2012	COG1040	competence protein
spr2013	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
spr2014	COG1739	Uncharacterized protein family UPF0029
spr2020	COG0052	Belongs to the universal ribosomal protein uS2 family
spr2021	COG3942	CHAP domain
spr2023	COG1792	Involved in formation and maintenance of cell shape
spr2024	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
spr2025	COG1122	ATPase activity
spr2026	COG1122	ATPase activity
spr2027	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
spr2029	COG0612	Peptidase, M16
spr2030	COG0612	Peptidase, M16
spr2031	COG2501	S4 domain
spr2033	COG0516	GMP reductase activity
spr2033	COG0517	IMP dehydrogenase activity
spr2034	COG0180	Tryptophanyl-tRNA synthetase
spr2035	COG0488	(ABC) transporter
spr2045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
spr2046	COG1475	DNA binding