locus-tag	class	description
E5Q10_RS00010	COG0592	DNA-directed DNA polymerase activity
E5Q10_RS00020	COG0012	GTP binding
E5Q10_RS00025	COG0193	aminoacyl-tRNA hydrolase activity
E5Q10_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E5Q10_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E5Q10_RS00050	COG0037	tRNA processing
E5Q10_RS00055	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E5Q10_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5Q10_RS00125	COG0756	dUTP diphosphatase activity
E5Q10_RS00135	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E5Q10_RS00150	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E5Q10_RS00175	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5Q10_RS00175	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5Q10_RS00180	COG1832	CoA-binding protein
E5Q10_RS00185	COG2855	membrane
E5Q10_RS00190	COG0436	Aminotransferase
E5Q10_RS00195	COG1381	Involved in DNA repair and RecF pathway recombination
E5Q10_RS00205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5Q10_RS00230	COG2274	protein secretion by the type I secretion system
E5Q10_RS00235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5Q10_RS00240	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E5Q10_RS00250	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5Q10_RS00255	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E5Q10_RS00260	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E5Q10_RS00265	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E5Q10_RS00275	COG0138	bifunctional purine biosynthesis protein purh
E5Q10_RS00280	COG0151	Belongs to the GarS family
E5Q10_RS00295	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E5Q10_RS00310	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E5Q10_RS00315	COG3525	Glycosyl hydrolase, family 20, catalytic domain
E5Q10_RS00315	COG3583	domain protein
E5Q10_RS00315	COG3064	Membrane
E5Q10_RS00330	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5Q10_RS00335	COG3715	PTS system
E5Q10_RS00340	COG3716	PTS system mannose fructose sorbose family IID component
E5Q10_RS00350	COG2222	sugar isomerase
E5Q10_RS00360	COG2514	catechol 2,3-dioxygenase activity
E5Q10_RS00365	COG1937	Protein conserved in bacteria
E5Q10_RS00405	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5Q10_RS00410	COG0569	domain protein
E5Q10_RS00415	COG1215	transferase activity, transferring glycosyl groups
E5Q10_RS00435	COG5002	protein histidine kinase activity
E5Q10_RS00465	COG4209	transmembrane transport
E5Q10_RS00470	COG0395	ABC-type sugar transport system, permease component
E5Q10_RS00480	COG1653	transport
E5Q10_RS00510	COG1695	Transcriptional regulator
E5Q10_RS00535	COG0546	phosphoglycolate phosphatase activity
E5Q10_RS00540	COG1760	l-serine dehydratase
E5Q10_RS00545	COG1760	l-serine dehydratase
E5Q10_RS00575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5Q10_RS00580	COG0137	argininosuccinate synthase activity
E5Q10_RS00605	COG2274	protein secretion by the type I secretion system
E5Q10_RS00700	COG0482	sulfurtransferase activity
E5Q10_RS00705	COG0494	nUDIX hydrolase
E5Q10_RS00710	COG0445	tRNA wobble uridine modification
E5Q10_RS00745	COG1214	PFAM Peptidase M22, glycoprotease
E5Q10_RS00755	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E5Q10_RS00775	COG0438	transferase activity, transferring glycosyl groups
E5Q10_RS00810	COG1396	sequence-specific DNA binding
E5Q10_RS00840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5Q10_RS00845	COG1464	Belongs to the NlpA lipoprotein family
E5Q10_RS00850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5Q10_RS00855	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E5Q10_RS00875	COG2972	Histidine kinase
E5Q10_RS00880	COG4753	response regulator
E5Q10_RS00880	COG2207	Transcriptional regulator
E5Q10_RS00890	COG1780	Probably involved in ribonucleotide reductase function
E5Q10_RS00930	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E5Q10_RS00930	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E5Q10_RS00950	COG2818	Glycosylase
E5Q10_RS00975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E5Q10_RS00980	COG0006	proline dipeptidase activity
E5Q10_RS00990	COG1393	Belongs to the ArsC family
E5Q10_RS01015	COG0285	dihydrofolate synthase activity
E5Q10_RS01025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5Q10_RS01055	COG0602	queuosine metabolic process
E5Q10_RS01090	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E5Q10_RS01115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E5Q10_RS01155	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E5Q10_RS01170	COG0201	protein transport
E5Q10_RS01180	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E5Q10_RS01185	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E5Q10_RS01195	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E5Q10_RS01200	COG0202	RNA polymerase activity
E5Q10_RS01210	COG3830	Belongs to the UPF0237 family
E5Q10_RS01230	COG1178	ABC-type Fe3 transport system permease component
E5Q10_RS01235	COG3842	ATPase activity
E5Q10_RS01250	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E5Q10_RS01255	COG1349	DNA-binding transcription factor activity
E5Q10_RS01265	COG1447	Phosphotransferase system cellobiose-specific component IIA
E5Q10_RS01270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E5Q10_RS01275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E5Q10_RS01280	COG1882	Formate acetyltransferase
E5Q10_RS01295	COG0495	leucyl-tRNA aminoacylation
E5Q10_RS01325	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E5Q10_RS01330	COG4589	Belongs to the CDS family
E5Q10_RS01335	COG0750	zinc metalloprotease
E5Q10_RS01340	COG0442	prolyl-tRNA aminoacylation
E5Q10_RS01345	COG2723	6-phospho-beta-galactosidase activity
E5Q10_RS01350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E5Q10_RS01360	COG1523	belongs to the glycosyl hydrolase 13 family
E5Q10_RS01385	COG2176	DNA-directed DNA polymerase activity
E5Q10_RS01405	COG2309	aminopeptidase activity
E5Q10_RS01410	COG2261	transglycosylase associated protein
E5Q10_RS01415	COG1187	pseudouridine synthase activity
E5Q10_RS01425	COG3579	cysteine-type endopeptidase activity
E5Q10_RS01430	COG3716	PTS system mannose fructose sorbose family IID component
E5Q10_RS01435	COG3715	PTS system
E5Q10_RS01445	COG1064	alcohol dehydrogenase
E5Q10_RS01450	COG0561	phosphatase activity
E5Q10_RS01455	COG2252	PERMEase
E5Q10_RS01465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E5Q10_RS01470	COG0285	dihydrofolate synthase activity
E5Q10_RS01475	COG0302	gtp cyclohydrolase
E5Q10_RS01480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E5Q10_RS01480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E5Q10_RS01490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E5Q10_RS01515	COG2723	6-phospho-beta-galactosidase activity
E5Q10_RS01530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5Q10_RS01530	COG3711	transcriptional antiterminator
E5Q10_RS01545	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E5Q10_RS01565	COG0386	Belongs to the glutathione peroxidase family
E5Q10_RS01570	COG5492	domain, Protein
E5Q10_RS01605	COG1028	Short-chain dehydrogenase reductase Sdr
E5Q10_RS01615	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
E5Q10_RS01620	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5Q10_RS01625	COG3715	PTS system
E5Q10_RS01630	COG3716	PTS system mannose fructose sorbose family IID component
E5Q10_RS01645	COG1609	Transcriptional regulator
E5Q10_RS01670	COG4839	cell division protein FtsL
E5Q10_RS01675	COG0768	penicillin binding
E5Q10_RS01680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E5Q10_RS01695	COG4868	Belongs to the UPF0371 family
E5Q10_RS01700	COG0366	Alpha amylase catalytic
E5Q10_RS01705	COG4166	transmembrane transport
E5Q10_RS01735	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E5Q10_RS01740	COG0562	UDP-galactopyranose mutase
E5Q10_RS01745	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E5Q10_RS01755	COG1088	dTDP-glucose 4,6-dehydratase activity
E5Q10_RS01760	COG1091	dTDP-4-dehydrorhamnose reductase activity
E5Q10_RS01770	COG4372	Transposase
E5Q10_RS01780	COG4166	transmembrane transport
E5Q10_RS01790	COG0366	Alpha amylase catalytic
E5Q10_RS01795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5Q10_RS01820	COG0116	Belongs to the methyltransferase superfamily
E5Q10_RS01830	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E5Q10_RS01835	COG0745	RESPONSE REGULATOR receiver
E5Q10_RS01860	COG1304	FMN binding
E5Q10_RS01870	COG4585	Histidine kinase
E5Q10_RS01875	COG2197	response regulator
E5Q10_RS01915	COG2213	PTS system mannitol-specific
E5Q10_RS01920	COG3711	transcriptional antiterminator
E5Q10_RS01925	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5Q10_RS01930	COG0246	Mannitol dehydrogenase
E5Q10_RS01940	COG0544	peptidyl-prolyl cis-trans isomerase activity
E5Q10_RS01945	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5Q10_RS01950	COG0681	Belongs to the peptidase S26 family
E5Q10_RS01970	COG1193	negative regulation of DNA recombination
E5Q10_RS01975	COG1115	amino acid carrier protein
E5Q10_RS01990	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E5Q10_RS02000	COG0527	aspartate kinase activity
E5Q10_RS02010	COG1024	Enoyl-CoA hydratase
E5Q10_RS02015	COG1846	Transcriptional regulator
E5Q10_RS02025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5Q10_RS02035	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E5Q10_RS02040	COG1028	Short-chain dehydrogenase reductase Sdr
E5Q10_RS02045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5Q10_RS02060	COG0439	Biotin carboxylase
E5Q10_RS02065	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E5Q10_RS02105	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5Q10_RS02125	COG1442	glycosyl transferase family 8
E5Q10_RS02130	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E5Q10_RS02140	COG1461	Dihydroxyacetone kinase
E5Q10_RS02145	COG0028	Belongs to the TPP enzyme family
E5Q10_RS02150	COG0440	acetolactate synthase activity
E5Q10_RS02170	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E5Q10_RS02190	COG0765	amino acid transport
E5Q10_RS02210	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E5Q10_RS02215	COG1882	Formate acetyltransferase
E5Q10_RS02245	COG1846	Transcriptional regulator
E5Q10_RS02245	COG1940	carbohydrate kinase activity
E5Q10_RS02250	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E5Q10_RS02260	COG1447	Phosphotransferase system cellobiose-specific component IIA
E5Q10_RS02265	COG2723	6-phospho-beta-galactosidase activity
E5Q10_RS02270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E5Q10_RS02270	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E5Q10_RS02275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5Q10_RS02280	COG0569	domain protein
E5Q10_RS02295	COG1122	ATPase activity
E5Q10_RS02310	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
E5Q10_RS02315	COG0671	phosphoesterase, PA-phosphatase related
E5Q10_RS02325	COG1247	-acetyltransferase
E5Q10_RS02335	COG0504	CTP synthase activity
E5Q10_RS02340	COG1283	sodium-dependent phosphate transmembrane transporter activity
E5Q10_RS02350	COG0126	phosphoglycerate kinase activity
E5Q10_RS02360	COG0789	Transcriptional regulator
E5Q10_RS02365	COG0174	glutamine synthetase
E5Q10_RS02385	COG0732	type I restriction modification DNA specificity domain
E5Q10_RS02395	COG4974	Belongs to the 'phage' integrase family
E5Q10_RS02430	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E5Q10_RS02445	COG0484	heat shock protein binding
E5Q10_RS02455	COG0537	adenosine 5'-monophosphoramidase activity
E5Q10_RS02460	COG1131	(ABC) transporter
E5Q10_RS02485	COG3290	protein histidine kinase activity
E5Q10_RS02525	COG1266	CAAX protease self-immunity
E5Q10_RS02545	COG0195	Participates in both transcription termination and antitermination
E5Q10_RS02550	COG2740	Nucleic-acid-binding protein implicated in transcription termination
E5Q10_RS02565	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E5Q10_RS02610	COG0519	Catalyzes the synthesis of GMP from XMP
E5Q10_RS02620	COG0525	valine-tRNA ligase activity
E5Q10_RS02655	COG3711	transcriptional antiterminator
E5Q10_RS02660	COG2190	(PTS) system
E5Q10_RS02660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5Q10_RS02660	COG1263	PTS System
E5Q10_RS02675	COG0456	acetyltransferase
E5Q10_RS02680	COG0072	phenylalanine-tRNA ligase activity
E5Q10_RS02680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5Q10_RS02695	COG3620	sequence-specific DNA binding
E5Q10_RS02700	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E5Q10_RS02715	COG1185	polyribonucleotide nucleotidyltransferase activity
E5Q10_RS02720	COG1045	serine acetyltransferase
E5Q10_RS02735	COG0215	cysteine-tRNA ligase activity
E5Q10_RS02740	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
E5Q10_RS02755	COG0577	efflux transmembrane transporter activity
E5Q10_RS02760	COG1136	(ABC) transporter
E5Q10_RS02765	COG0577	efflux transmembrane transporter activity
E5Q10_RS02770	COG0745	RESPONSE REGULATOR receiver
E5Q10_RS02775	COG5002	protein histidine kinase activity
E5Q10_RS02780	COG0191	fructose-bisphosphate aldolase activity
E5Q10_RS02785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5Q10_RS02795	COG0765	amino acid transport
E5Q10_RS02800	COG0765	amino acid transport
E5Q10_RS02805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5Q10_RS02815	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E5Q10_RS02815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E5Q10_RS02845	COG0322	excinuclease ABC activity
E5Q10_RS02855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5Q10_RS02870	COG1573	uracil-dna glycosylase
E5Q10_RS02885	COG1114	Component of the transport system for branched-chain amino acids
E5Q10_RS02890	COG1363	Peptidase, m42
E5Q10_RS02930	COG4555	ABC transporter
E5Q10_RS02965	COG1404	Belongs to the peptidase S8 family
E5Q10_RS02980	COG3775	system Galactitol-specific IIC component
E5Q10_RS02990	COG3250	beta-galactosidase activity
E5Q10_RS03020	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
E5Q10_RS03040	COG0785	Cytochrome C biogenesis protein
E5Q10_RS03045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5Q10_RS03050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5Q10_RS03050	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5Q10_RS03060	COG4753	response regulator
E5Q10_RS03060	COG2207	Transcriptional regulator
E5Q10_RS03065	COG2972	Histidine kinase
E5Q10_RS03070	COG4475	Protein of unknown function (DUF436)
E5Q10_RS03075	COG3064	Membrane
E5Q10_RS03080	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E5Q10_RS03095	COG1940	carbohydrate kinase activity
E5Q10_RS03110	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E5Q10_RS03115	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E5Q10_RS03120	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
E5Q10_RS03130	COG0300	oxidoreductase activity
E5Q10_RS03145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5Q10_RS03155	COG1187	pseudouridine synthase activity
E5Q10_RS03160	COG1217	gtp-binding protein TYPA
E5Q10_RS03180	COG1136	(ABC) transporter
E5Q10_RS03185	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E5Q10_RS03190	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E5Q10_RS03195	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E5Q10_RS03235	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E5Q10_RS03260	COG1131	(ABC) transporter
E5Q10_RS03270	COG1126	abc transporter atp-binding protein
E5Q10_RS03275	COG0765	amino acid transport
E5Q10_RS03285	COG1304	FMN binding
E5Q10_RS03300	COG1304	FMN binding
E5Q10_RS03315	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
E5Q10_RS03320	COG0352	thiamine-phosphate diphosphorylase activity
E5Q10_RS03335	COG4172	Belongs to the ABC transporter superfamily
E5Q10_RS03345	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E5Q10_RS03355	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
E5Q10_RS03360	COG0352	thiamine-phosphate diphosphorylase activity
E5Q10_RS03380	COG2217	Heavy metal translocating P-type atpase
E5Q10_RS03385	COG0028	Belongs to the TPP enzyme family
E5Q10_RS03400	COG2723	6-phospho-beta-galactosidase activity
E5Q10_RS03405	COG1482	cell wall glycoprotein biosynthetic process
E5Q10_RS03410	COG0733	neurotransmitter:sodium symporter activity
E5Q10_RS03425	COG2081	HI0933 family
E5Q10_RS03430	COG1307	EDD domain protein, DegV family
E5Q10_RS03440	COG2131	deaminase
E5Q10_RS03445	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E5Q10_RS03490	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E5Q10_RS03490	COG0617	tRNA 3'-terminal CCA addition
E5Q10_RS03490	COG0517	IMP dehydrogenase activity
E5Q10_RS03500	COG2884	Cell division ATP-binding protein ftsE
E5Q10_RS03505	COG2177	Part of the ABC transporter FtsEX involved in
E5Q10_RS03510	COG2190	(PTS) system
E5Q10_RS03510	COG1263	PTS System
E5Q10_RS03510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5Q10_RS03520	COG0513	Belongs to the DEAD box helicase family
E5Q10_RS03535	COG0167	dihydroorotate dehydrogenase activity
E5Q10_RS03545	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E5Q10_RS03550	COG4470	Protein conserved in bacteria
E5Q10_RS03555	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E5Q10_RS03565	COG0488	(ABC) transporter
E5Q10_RS03595	COG1837	Belongs to the UPF0109 family
E5Q10_RS03625	COG1328	CTP reductase activity
E5Q10_RS03625	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E5Q10_RS03635	COG4443	Transcriptional Coactivator p15 (PC4)
E5Q10_RS03645	COG1268	BioY protein
E5Q10_RS03650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5Q10_RS03655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5Q10_RS03660	COG1136	(ABC) transporter
E5Q10_RS03665	COG0577	efflux transmembrane transporter activity
E5Q10_RS03670	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5Q10_RS03670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5Q10_RS03690	COG4989	oxidoreductase activity
E5Q10_RS03700	COG1028	Short-chain dehydrogenase reductase Sdr
E5Q10_RS03730	COG0745	RESPONSE REGULATOR receiver
E5Q10_RS03735	COG5002	protein histidine kinase activity
E5Q10_RS03755	COG0772	Belongs to the SEDS family
E5Q10_RS03760	COG0693	protein deglycase activity
E5Q10_RS03770	COG0187	DNA topoisomerase II activity
E5Q10_RS03805	COG0494	nUDIX hydrolase
E5Q10_RS03815	COG0542	response to heat
E5Q10_RS03820	COG4703	Protein of unknown function (DUF1797)
E5Q10_RS03825	COG0765	amino acid transport
E5Q10_RS03830	COG1126	abc transporter atp-binding protein
E5Q10_RS03835	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E5Q10_RS03840	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E5Q10_RS03850	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E5Q10_RS03860	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E5Q10_RS03915	COG2813	Specifically methylates the guanine in position
E5Q10_RS03920	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E5Q10_RS03925	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E5Q10_RS03930	COG0295	cytidine deaminase activity
E5Q10_RS03935	COG1744	ABC transporter substrate-binding protein PnrA-like
E5Q10_RS03940	COG3845	ABC transporter
E5Q10_RS03945	COG4603	Belongs to the binding-protein-dependent transport system permease family
E5Q10_RS03950	COG1079	Belongs to the binding-protein-dependent transport system permease family
E5Q10_RS03965	COG0187	DNA topoisomerase II activity
E5Q10_RS03970	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E5Q10_RS03975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E5Q10_RS03980	COG4166	transmembrane transport
E5Q10_RS04015	COG0539	negative regulation of cytoplasmic translation
E5Q10_RS04025	COG1956	GAF domain-containing protein
E5Q10_RS04030	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E5Q10_RS04045	COG0719	Fe-S assembly protein
E5Q10_RS04050	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E5Q10_RS04060	COG0719	Fe-S assembly protein
E5Q10_RS04065	COG1686	Belongs to the peptidase S11 family
E5Q10_RS04070	COG0628	permease
E5Q10_RS04090	COG1349	DNA-binding transcription factor activity
E5Q10_RS04095	COG1105	Belongs to the carbohydrate kinase PfkB family
E5Q10_RS04100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5Q10_RS04100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5Q10_RS04100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5Q10_RS04105	COG1674	ftsk spoiiie
E5Q10_RS04105	COG0697	spore germination
E5Q10_RS04115	COG1104	cysteine desulfurase activity
E5Q10_RS04120	COG0301	tRNA thio-modification
E5Q10_RS04150	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
E5Q10_RS04160	COG1438	arginine binding
E5Q10_RS04165	COG2936	dipeptidyl-peptidase activity
E5Q10_RS04175	COG0205	6-phosphofructokinase activity
E5Q10_RS04180	COG0469	pyruvate kinase activity
E5Q10_RS04230	COG3689	TIGRFAM TIGR03943 family protein
E5Q10_RS04235	COG0701	Predicted permease
E5Q10_RS04250	COG3955	Domain of unknown function (DUF1919)
E5Q10_RS04255	COG2183	response to ionizing radiation
E5Q10_RS04275	COG1136	(ABC) transporter
E5Q10_RS04280	COG0577	efflux transmembrane transporter activity
E5Q10_RS04300	COG1982	Orn Lys Arg decarboxylase major
E5Q10_RS04310	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E5Q10_RS04325	COG2957	Belongs to the agmatine deiminase family
E5Q10_RS04330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5Q10_RS04335	COG0561	phosphatase activity
E5Q10_RS04355	COG0583	DNA-binding transcription factor activity
E5Q10_RS04360	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E5Q10_RS04365	COG0564	pseudouridine synthase activity
E5Q10_RS04370	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E5Q10_RS04375	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E5Q10_RS04385	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E5Q10_RS04390	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E5Q10_RS04395	COG0470	DNA polymerase III
E5Q10_RS04435	COG0528	UMP kinase activity
E5Q10_RS04440	COG0233	cytoplasmic translational termination
E5Q10_RS04445	COG2996	Protein conserved in bacteria
E5Q10_RS04455	COG1702	phosphate starvation-inducible protein PhoH
E5Q10_RS04475	COG0686	Belongs to the AlaDH PNT family
E5Q10_RS04480	COG0686	Belongs to the AlaDH PNT family
E5Q10_RS04485	COG0686	Belongs to the AlaDH PNT family
E5Q10_RS04490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5Q10_RS04495	COG1596	polysaccharide export
E5Q10_RS04495	COG1555	photosystem II stabilization
E5Q10_RS04500	COG2333	competence protein COMEC
E5Q10_RS04500	COG0658	competence protein
E5Q10_RS04510	COG1131	(ABC) transporter
E5Q10_RS04540	COG0543	2 iron, 2 sulfur cluster binding
E5Q10_RS04545	COG0167	dihydroorotate dehydrogenase activity
E5Q10_RS04550	COG5263	repeat protein
E5Q10_RS04550	COG4193	domain, Protein
E5Q10_RS04555	COG1293	RNA-binding protein homologous to eukaryotic snRNP
E5Q10_RS04565	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E5Q10_RS04575	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E5Q10_RS04580	COG0237	dephospho-CoA kinase activity
E5Q10_RS04585	COG2814	Major facilitator Superfamily
E5Q10_RS04600	COG0557	exoribonuclease II activity
E5Q10_RS04610	COG3615	Tellurite resistance protein tehB
E5Q10_RS04610	COG0500	methyltransferase
E5Q10_RS04625	COG4122	O-methyltransferase activity
E5Q10_RS04655	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E5Q10_RS04670	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E5Q10_RS04675	COG0494	nUDIX hydrolase
E5Q10_RS04685	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E5Q10_RS04695	COG2176	DNA-directed DNA polymerase activity
E5Q10_RS04700	COG0584	glycerophosphoryl diester phosphodiesterase
E5Q10_RS04720	COG0785	Cytochrome C biogenesis protein
E5Q10_RS04725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5Q10_RS04730	COG0531	amino acid
E5Q10_RS04735	COG3443	Belongs to the bacterial solute-binding protein 9 family
E5Q10_RS04735	COG0803	Belongs to the bacterial solute-binding protein 9 family
E5Q10_RS04770	COG2195	Cleaves the N-terminal amino acid of tripeptides
E5Q10_RS04775	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E5Q10_RS04780	COG1970	mechanosensitive ion channel activity
E5Q10_RS04790	COG4708	membrane
E5Q10_RS04800	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E5Q10_RS04805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5Q10_RS04810	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E5Q10_RS04815	COG1942	4-Oxalocrotonate Tautomerase
E5Q10_RS04820	COG1435	thymidine kinase activity
E5Q10_RS04835	COG2890	protein-(glutamine-N5) methyltransferase activity
E5Q10_RS04850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E5Q10_RS04860	COG0741	lytic transglycosylase activity
E5Q10_RS04870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E5Q10_RS04895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5Q10_RS04900	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5Q10_RS04950	COG1597	lipid kinase activity
E5Q10_RS04955	COG0366	Alpha amylase catalytic
E5Q10_RS04970	COG1396	sequence-specific DNA binding
E5Q10_RS04975	COG0542	response to heat
E5Q10_RS05000	COG3843	relaxase mobilization nuclease domain protein
E5Q10_RS05050	COG0318	PFAM AMP-dependent synthetase and ligase
E5Q10_RS05095	COG0772	Belongs to the SEDS family
E5Q10_RS05100	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E5Q10_RS05120	COG0358	DNA primase activity
E5Q10_RS05125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E5Q10_RS05130	COG2151	metal-sulfur cluster biosynthetic enzyme
E5Q10_RS05135	COG0438	transferase activity, transferring glycosyl groups
E5Q10_RS05140	COG0438	transferase activity, transferring glycosyl groups
E5Q10_RS05155	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E5Q10_RS05170	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E5Q10_RS05180	COG4109	DRTGG domain
E5Q10_RS05185	COG0024	Methionine aminopeptidase
E5Q10_RS05200	COG0210	DNA helicase
E5Q10_RS05205	COG2003	Belongs to the UPF0758 family
E5Q10_RS05210	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E5Q10_RS05215	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E5Q10_RS05230	COG1104	cysteine desulfurase activity
E5Q10_RS05235	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E5Q10_RS05245	COG2357	RelA SpoT domain protein
E5Q10_RS05255	COG0564	pseudouridine synthase activity
E5Q10_RS05260	COG0280	phosphate acetyltransferase
E5Q10_RS05300	COG0196	riboflavin kinase activity
E5Q10_RS05305	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E5Q10_RS05310	COG1307	EDD domain protein, DegV family
E5Q10_RS05320	COG0488	(ABC) transporter
E5Q10_RS05335	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E5Q10_RS05340	COG1523	belongs to the glycosyl hydrolase 13 family
E5Q10_RS05345	COG1012	belongs to the aldehyde dehydrogenase family
E5Q10_RS05355	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E5Q10_RS05360	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E5Q10_RS05365	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E5Q10_RS05370	COG0297	glycogen (starch) synthase activity
E5Q10_RS05395	COG0582	viral genome integration into host DNA
E5Q10_RS05415	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
E5Q10_RS05420	COG1074	ATP-dependent DNA helicase activity
E5Q10_RS05435	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E5Q10_RS05435	COG3583	domain protein
E5Q10_RS05450	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E5Q10_RS05455	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E5Q10_RS05470	COG0095	Lipoate-protein ligase
E5Q10_RS05475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5Q10_RS05480	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5Q10_RS05485	COG0022	dehydrogenase e1 component
E5Q10_RS05490	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E5Q10_RS05495	COG0534	Mate efflux family protein
E5Q10_RS05505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E5Q10_RS05510	COG1051	belongs to the nudix hydrolase family
E5Q10_RS05525	COG1011	Hydrolase
E5Q10_RS05550	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5Q10_RS05555	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E5Q10_RS05560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5Q10_RS05565	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5Q10_RS05580	COG2723	6-phospho-beta-galactosidase activity
E5Q10_RS05595	COG3711	transcriptional antiterminator
E5Q10_RS05600	COG3684	Belongs to the aldolase LacD family
E5Q10_RS05650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E5Q10_RS05655	COG0497	DNA recombination
E5Q10_RS05660	COG1438	arginine binding
E5Q10_RS05665	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E5Q10_RS05680	COG1570	exodeoxyribonuclease VII activity
E5Q10_RS05700	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E5Q10_RS05725	COG3764	Sortase (surface protein transpeptidase)
E5Q10_RS05730	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E5Q10_RS05760	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E5Q10_RS05765	COG5002	protein histidine kinase activity
E5Q10_RS05770	COG0745	RESPONSE REGULATOR receiver
E5Q10_RS05775	COG1194	a g-specific adenine glycosylase
E5Q10_RS05795	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E5Q10_RS05800	COG4684	Psort location CytoplasmicMembrane, score
E5Q10_RS05810	COG1827	regulation of RNA biosynthetic process
E5Q10_RS05830	COG0556	nucleotide-excision repair
E5Q10_RS05840	COG0765	amino acid transport
E5Q10_RS05845	COG1126	abc transporter atp-binding protein
E5Q10_RS05850	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E5Q10_RS05855	COG0552	protein localization to endoplasmic reticulum
E5Q10_RS05860	COG0561	phosphatase activity
E5Q10_RS05865	COG0561	phosphatase activity
E5Q10_RS05870	COG1196	nuclear chromosome segregation
E5Q10_RS05895	COG1401	restriction endodeoxyribonuclease activity
E5Q10_RS05905	COG0066	3-isopropylmalate dehydratase activity
E5Q10_RS05915	COG0473	3-isopropylmalate dehydrogenase activity
E5Q10_RS05930	COG3142	Participates in the control of copper homeostasis
E5Q10_RS05935	COG2832	Protein of unknown function (DUF454)
E5Q10_RS05940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E5Q10_RS05955	COG0758	DNA mediated transformation
E5Q10_RS05960	COG4750	Nucleotidyl transferase
E5Q10_RS05975	COG1063	alcohol dehydrogenase
E5Q10_RS05980	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E5Q10_RS05990	COG3475	LICD family
E5Q10_RS05995	COG3475	LICD family
E5Q10_RS06000	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E5Q10_RS06005	COG0505	Belongs to the CarA family
E5Q10_RS06010	COG0540	Belongs to the ATCase OTCase family
E5Q10_RS06020	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E5Q10_RS06035	COG0488	(ABC) transporter
E5Q10_RS06045	COG1704	LemA family
E5Q10_RS06060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E5Q10_RS06075	COG1078	dGTPase activity
E5Q10_RS06090	COG0335	large ribosomal subunit rRNA binding
E5Q10_RS06095	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E5Q10_RS06100	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E5Q10_RS06105	COG1605	Chorismate mutase
E5Q10_RS06105	COG0077	Prephenate dehydratase
E5Q10_RS06110	COG0716	FMN binding
E5Q10_RS06115	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E5Q10_RS06140	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E5Q10_RS06180	COG0295	cytidine deaminase activity
E5Q10_RS06185	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E5Q10_RS06200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5Q10_RS06205	COG0601	transmembrane transport
E5Q10_RS06220	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
E5Q10_RS06255	COG1136	(ABC) transporter
E5Q10_RS06255	COG0577	efflux transmembrane transporter activity
E5Q10_RS06265	COG1770	oligopeptidase
E5Q10_RS06270	COG0515	serine threonine protein kinase
E5Q10_RS06325	COG0402	S-adenosylhomocysteine deaminase activity
E5Q10_RS06340	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5Q10_RS06340	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5Q10_RS06360	COG4862	establishment of competence for transformation
E5Q10_RS06375	COG1215	transferase activity, transferring glycosyl groups
E5Q10_RS06385	COG3475	LICD family
E5Q10_RS06395	COG0077	Prephenate dehydratase
E5Q10_RS06400	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E5Q10_RS06405	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E5Q10_RS06415	COG0287	Prephenate dehydrogenase
E5Q10_RS06440	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E5Q10_RS06455	COG1131	(ABC) transporter
E5Q10_RS06465	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E5Q10_RS06495	COG3842	ATPase activity
E5Q10_RS06510	COG3527	Alpha-acetolactate decarboxylase
E5Q10_RS06515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5Q10_RS06520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5Q10_RS06525	COG0704	Plays a role in the regulation of phosphate uptake
E5Q10_RS06530	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E5Q10_RS06535	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E5Q10_RS06540	COG0581	inorganic phosphate transmembrane transporter activity
E5Q10_RS06545	COG0573	inorganic phosphate transmembrane transporter activity
E5Q10_RS06550	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E5Q10_RS06555	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5Q10_RS06555	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E5Q10_RS06560	COG0483	inositol monophosphate 1-phosphatase activity
E5Q10_RS06570	COG1393	Belongs to the ArsC family
E5Q10_RS06580	COG0647	UMP catabolic process
E5Q10_RS06590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5Q10_RS06610	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E5Q10_RS06625	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E5Q10_RS06635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5Q10_RS06645	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E5Q10_RS06665	COG1131	(ABC) transporter
E5Q10_RS06680	COG0826	peptidase U32
E5Q10_RS06715	COG1132	(ABC) transporter
E5Q10_RS06730	COG1129	ABC transporter
E5Q10_RS06775	COG2188	Transcriptional regulator
E5Q10_RS06780	COG0697	spore germination
E5Q10_RS06785	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E5Q10_RS06800	COG0561	phosphatase activity
E5Q10_RS06835	COG0492	ferredoxin-NADP+ reductase activity
E5Q10_RS06845	COG1126	abc transporter atp-binding protein
E5Q10_RS06855	COG1393	Belongs to the ArsC family
E5Q10_RS06860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E5Q10_RS06875	COG1272	protein, Hemolysin III
E5Q10_RS06880	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
E5Q10_RS06905	COG1053	succinate dehydrogenase
E5Q10_RS06905	COG0431	NADPH-dependent FMN reductase
E5Q10_RS06905	COG3976	FMN-binding domain protein
E5Q10_RS06915	COG0751	glycine-tRNA ligase activity
E5Q10_RS06920	COG0752	glycyl-tRNA synthetase alpha subunit
E5Q10_RS06930	COG0656	L-ascorbic acid biosynthetic process
E5Q10_RS06935	COG0726	polysaccharide deacetylase
E5Q10_RS06985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E5Q10_RS07020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5Q10_RS07035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5Q10_RS07040	COG1126	abc transporter atp-binding protein
E5Q10_RS07055	COG0628	permease
E5Q10_RS07060	COG2706	6-phosphogluconolactonase activity
E5Q10_RS07075	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E5Q10_RS07125	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E5Q10_RS07150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E5Q10_RS07155	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E5Q10_RS07160	COG0626	cystathionine gamma-synthase activity
E5Q10_RS07170	COG1132	(ABC) transporter
E5Q10_RS07180	COG4166	transmembrane transport
E5Q10_RS07185	COG2244	polysaccharide biosynthetic process
E5Q10_RS07190	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E5Q10_RS07215	COG2827	Endonuclease containing a URI domain
E5Q10_RS07220	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E5Q10_RS07225	COG1098	S1 RNA binding domain
E5Q10_RS07235	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E5Q10_RS07240	COG0629	single-stranded DNA binding
E5Q10_RS07250	COG0017	Asparaginyl-tRNA synthetase
E5Q10_RS07260	COG0436	Aminotransferase
E5Q10_RS07285	COG3711	transcriptional antiterminator
E5Q10_RS07310	COG0242	peptide deformylase activity
E5Q10_RS07315	COG0625	glutathione transferase activity
E5Q10_RS07325	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E5Q10_RS07330	COG0488	(ABC) transporter
E5Q10_RS07335	COG0617	tRNA 3'-terminal CCA addition
E5Q10_RS07345	COG1307	EDD domain protein, DegV family
E5Q10_RS07355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5Q10_RS07365	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E5Q10_RS07375	COG0492	ferredoxin-NADP+ reductase activity
E5Q10_RS07380	COG1481	regulation of sporulation
E5Q10_RS07385	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E5Q10_RS07390	COG1660	Displays ATPase and GTPase activities
E5Q10_RS07395	COG0251	oxidation-reduction process
E5Q10_RS07415	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E5Q10_RS07425	COG4193	domain, Protein
E5Q10_RS07425	COG5263	repeat protein
E5Q10_RS07435	COG3935	DnaD domain protein
E5Q10_RS07450	COG2226	methyltransferase
E5Q10_RS07455	COG3842	ATPase activity
E5Q10_RS07465	COG1335	isochorismatase
E5Q10_RS07470	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
E5Q10_RS07480	COG0513	Belongs to the DEAD box helicase family
E5Q10_RS07485	COG2223	nitrite transmembrane transporter activity
E5Q10_RS07490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5Q10_RS07495	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E5Q10_RS07500	COG3442	glutamine amidotransferase
E5Q10_RS07505	COG0006	proline dipeptidase activity
E5Q10_RS07520	COG4720	Psort location CytoplasmicMembrane, score
E5Q10_RS07525	COG0351	phosphomethylpyrimidine kinase
E5Q10_RS07550	COG2824	Alkylphosphonate utilization operon protein PhnA
E5Q10_RS07570	COG0463	Glycosyl transferase, family 2
E5Q10_RS07575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5Q10_RS07580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5Q10_RS07585	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E5Q10_RS07590	COG2384	SAM-dependent methyltransferase
E5Q10_RS07595	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E5Q10_RS07600	COG0204	Acyl-transferase
E5Q10_RS07615	COG2910	NAD(P)H-binding
E5Q10_RS07645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E5Q10_RS07650	COG5002	protein histidine kinase activity
E5Q10_RS07655	COG0745	RESPONSE REGULATOR receiver
E5Q10_RS07670	COG1959	2 iron, 2 sulfur cluster binding
E5Q10_RS07730	COG3590	peptidase
E5Q10_RS07745	COG0803	Belongs to the bacterial solute-binding protein 9 family
E5Q10_RS07750	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E5Q10_RS07760	COG1136	(ABC) transporter
E5Q10_RS07760	COG0577	efflux transmembrane transporter activity
E5Q10_RS07790	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E5Q10_RS07800	COG3599	regulation of cell shape
E5Q10_RS07820	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E5Q10_RS07840	COG1051	belongs to the nudix hydrolase family
E5Q10_RS07845	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E5Q10_RS07850	COG1181	Belongs to the D-alanine--D-alanine ligase family
E5Q10_RS07860	COG0768	penicillin binding
E5Q10_RS07895	COG2731	YhcH YjgK YiaL family protein
E5Q10_RS07900	COG0395	ABC-type sugar transport system, permease component
E5Q10_RS07905	COG1175	transmembrane transport
E5Q10_RS07915	COG2190	(PTS) system
E5Q10_RS07915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5Q10_RS07915	COG1263	PTS System
E5Q10_RS07925	COG0673	inositol 2-dehydrogenase activity
E5Q10_RS07930	COG4409	exo-alpha-(2->6)-sialidase activity
E5Q10_RS07940	COG1175	transmembrane transport
E5Q10_RS07945	COG1653	transport
E5Q10_RS07965	COG3458	cephalosporin-C deacetylase activity
E5Q10_RS07975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E5Q10_RS07990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5Q10_RS07995	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5Q10_RS08000	COG0653	protein targeting
E5Q10_RS08010	COG1131	(ABC) transporter
E5Q10_RS08055	COG1484	DNA-dependent DNA replication
E5Q10_RS08070	COG1725	Transcriptional regulator
E5Q10_RS08075	COG1131	(ABC) transporter
E5Q10_RS08085	COG1668	transmembrane transport
E5Q10_RS08090	COG4152	abc transporter atp-binding protein
E5Q10_RS08110	COG1940	carbohydrate kinase activity
E5Q10_RS08115	COG2190	(PTS) system
E5Q10_RS08115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5Q10_RS08115	COG1263	PTS System
E5Q10_RS08130	COG1621	beta-fructofuranosidase activity
E5Q10_RS08135	COG1609	Transcriptional regulator
E5Q10_RS08145	COG3425	synthase
E5Q10_RS08170	COG2815	serine threonine protein kinase
E5Q10_RS08170	COG0515	serine threonine protein kinase
E5Q10_RS08175	COG0631	protein serine/threonine phosphatase activity
E5Q10_RS08180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5Q10_RS08180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5Q10_RS08190	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E5Q10_RS08200	COG0194	GDP metabolic process
E5Q10_RS08210	COG4115	mRNA cleavage
E5Q10_RS08220	COG1323	Belongs to the UPF0348 family
E5Q10_RS08225	COG2226	methyltransferase
E5Q10_RS08230	COG0799	negative regulation of ribosome biogenesis
E5Q10_RS08240	COG1713	HD superfamily hydrolase involved in NAD metabolism
E5Q10_RS08245	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E5Q10_RS08250	COG1534	Rna-binding protein
E5Q10_RS08255	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E5Q10_RS08270	COG0668	transmembrane transport
E5Q10_RS08280	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E5Q10_RS08300	COG3118	belongs to the thioredoxin family
E5Q10_RS08305	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E5Q10_RS08320	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E5Q10_RS08330	COG1164	Oligoendopeptidase f
E5Q10_RS08335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E5Q10_RS08340	COG2264	protein methyltransferase activity
E5Q10_RS08345	COG1051	belongs to the nudix hydrolase family
E5Q10_RS08390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E5Q10_RS08400	COG1621	beta-fructofuranosidase activity
E5Q10_RS08405	COG0395	ABC-type sugar transport system, permease component
E5Q10_RS08410	COG1175	transmembrane transport
E5Q10_RS08420	COG1609	Transcriptional regulator
E5Q10_RS08425	COG3711	transcriptional antiterminator
E5Q10_RS08450	COG3237	CsbD-like
E5Q10_RS08485	COG0159	tryptophan synthase activity
E5Q10_RS08490	COG0133	tryptophan synthase activity
E5Q10_RS08495	COG0135	phosphoribosylanthranilate isomerase activity
E5Q10_RS08510	COG0512	Glutamine amidotransferase of anthranilate synthase
E5Q10_RS08515	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E5Q10_RS08535	COG1285	pathogenesis
E5Q10_RS08540	COG1178	ABC-type Fe3 transport system permease component
E5Q10_RS08560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5Q10_RS08565	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
E5Q10_RS08570	COG0704	Plays a role in the regulation of phosphate uptake
E5Q10_RS08585	COG5434	Belongs to the glycosyl hydrolase 28 family
E5Q10_RS08595	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E5Q10_RS08600	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5Q10_RS08610	COG1132	(ABC) transporter
E5Q10_RS08615	COG1132	(ABC) transporter
E5Q10_RS08635	COG0708	Exodeoxyribonuclease III
E5Q10_RS08650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5Q10_RS08655	COG2233	PERMEase
E5Q10_RS08675	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
E5Q10_RS08680	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E5Q10_RS08685	COG1609	Transcriptional regulator
E5Q10_RS08690	COG1063	alcohol dehydrogenase
E5Q10_RS08695	COG0789	Transcriptional regulator
E5Q10_RS08700	COG1230	cation diffusion facilitator family transporter
E5Q10_RS08710	COG3201	nicotinamide mononucleotide transporter
E5Q10_RS08725	COG1174	glycine betaine transport
E5Q10_RS08750	COG1363	Peptidase, m42
E5Q10_RS08765	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5Q10_RS08770	COG4605	iron ion homeostasis
E5Q10_RS08775	COG4604	ABC transporter, ATP-binding protein
E5Q10_RS08780	COG4607	ABC-type enterochelin transport system periplasmic component
E5Q10_RS08790	COG1187	pseudouridine synthase activity
E5Q10_RS08810	COG0517	IMP dehydrogenase activity
E5Q10_RS08820	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E5Q10_RS08835	COG0366	Alpha amylase catalytic
E5Q10_RS08845	COG1263	PTS System
E5Q10_RS08845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5Q10_RS08850	COG2188	Transcriptional regulator
E5Q10_RS08860	COG4608	Belongs to the ABC transporter superfamily
E5Q10_RS08865	COG0444	Belongs to the ABC transporter superfamily
E5Q10_RS08870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5Q10_RS08875	COG0601	transmembrane transport
E5Q10_RS08880	COG4166	transmembrane transport
E5Q10_RS08895	COG0366	Alpha amylase catalytic
E5Q10_RS08900	COG0395	ABC-type sugar transport system, permease component
E5Q10_RS08905	COG1175	transmembrane transport
E5Q10_RS08910	COG1653	transport
E5Q10_RS08915	COG3345	alpha-galactosidase
E5Q10_RS08920	COG2207	Transcriptional regulator
E5Q10_RS08925	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E5Q10_RS08925	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E5Q10_RS09045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E5Q10_RS09075	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E5Q10_RS09085	COG4221	oxidoreductase activity
E5Q10_RS09090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5Q10_RS09095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5Q10_RS09220	COG5263	repeat protein
E5Q10_RS09220	COG5632	N-Acetylmuramoyl-L-alanine amidase
E5Q10_RS09240	COG1058	Belongs to the CinA family
E5Q10_RS09240	COG1546	Belongs to the CinA family
E5Q10_RS09245	COG1316	TRANSCRIPTIONal
E5Q10_RS09255	COG0802	atpase or kinase
E5Q10_RS09320	COG1136	(ABC) transporter
E5Q10_RS09330	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E5Q10_RS09345	COG1253	flavin adenine dinucleotide binding
E5Q10_RS09360	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E5Q10_RS09370	COG3480	Lon protease (S16) C-terminal proteolytic domain
E5Q10_RS09375	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E5Q10_RS09380	COG0742	ribosomal rna small subunit methyltransferase
E5Q10_RS09385	COG2502	aspartate--ammonia ligase
E5Q10_RS09400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5Q10_RS09405	COG1254	Belongs to the acylphosphatase family
E5Q10_RS09410	COG0706	membrane insertase activity
E5Q10_RS09415	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E5Q10_RS09425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5Q10_RS09445	COG1564	THIamine pyrophosphokinase
E5Q10_RS09455	COG1162	GTPase activity
E5Q10_RS09460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E5Q10_RS09485	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
E5Q10_RS09490	COG0084	hydrolase, TatD family'
E5Q10_RS09510	COG0436	Aminotransferase
E5Q10_RS09520	COG0589	response to stress
E5Q10_RS09525	COG0561	phosphatase activity
E5Q10_RS09530	COG0252	asparaginase activity
E5Q10_RS09540	COG1609	Transcriptional regulator
E5Q10_RS09545	COG2197	response regulator
E5Q10_RS09550	COG4585	Histidine kinase
E5Q10_RS09555	COG0842	Transport permease protein
E5Q10_RS09560	COG1131	(ABC) transporter
E5Q10_RS09660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E5Q10_RS09665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5Q10_RS09670	COG0564	pseudouridine synthase activity
E5Q10_RS09680	COG0577	efflux transmembrane transporter activity
E5Q10_RS09690	COG0157	Belongs to the NadC ModD family
E5Q10_RS09705	COG1129	ABC transporter
E5Q10_RS09710	COG2188	Transcriptional regulator
E5Q10_RS09715	COG2723	6-phospho-beta-galactosidase activity
E5Q10_RS09720	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E5Q10_RS09730	COG1447	Phosphotransferase system cellobiose-specific component IIA
E5Q10_RS09735	COG1012	belongs to the aldehyde dehydrogenase family
E5Q10_RS09735	COG1454	alcohol dehydrogenase
E5Q10_RS09745	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E5Q10_RS09755	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E5Q10_RS09775	COG3623	hexulose-6-phosphate isomerase
E5Q10_RS09785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5Q10_RS09795	COG3037	sugar-specific permease SgaT UlaA
E5Q10_RS09805	COG1847	R3H domain protein
E5Q10_RS09810	COG0706	membrane insertase activity
E5Q10_RS09820	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E5Q10_RS09855	COG4537	Required for transformation and DNA binding
E5Q10_RS09860	COG1459	type II secretion system
E5Q10_RS09865	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E5Q10_RS09875	COG1063	alcohol dehydrogenase
E5Q10_RS09920	COG0131	Imidazoleglycerol-phosphate dehydratase
E5Q10_RS09920	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E5Q10_RS09925	COG0534	Mate efflux family protein
E5Q10_RS10025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5Q10_RS10040	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E5Q10_RS10045	COG1132	(ABC) transporter
E5Q10_RS10055	COG1132	(ABC) transporter
E5Q10_RS10065	COG1438	arginine binding
E5Q10_RS10085	COG0745	RESPONSE REGULATOR receiver
E5Q10_RS10090	COG5002	protein histidine kinase activity
E5Q10_RS10095	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E5Q10_RS10100	COG0573	inorganic phosphate transmembrane transporter activity
E5Q10_RS10110	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E5Q10_RS10115	COG0704	Plays a role in the regulation of phosphate uptake
E5Q10_RS10135	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E5Q10_RS10145	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E5Q10_RS10160	COG0697	spore germination
E5Q10_RS10165	COG4499	WXG100 protein secretion system (Wss), protein YukC
E5Q10_RS10165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5Q10_RS10175	COG2217	Heavy metal translocating P-type atpase
E5Q10_RS10185	COG2226	methyltransferase
E5Q10_RS10205	COG0058	SHG alpha-glucan phosphorylase activity
E5Q10_RS10210	COG1640	4-alpha-glucanotransferase
E5Q10_RS10215	COG2182	Extracellular solute-binding protein
E5Q10_RS10220	COG1175	transmembrane transport
E5Q10_RS10225	COG3833	ABC-type maltose transport systems, permease component
E5Q10_RS10235	COG5521	maltodextrose utilization protein MalA
E5Q10_RS10240	COG1609	Transcriptional regulator
E5Q10_RS10250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E5Q10_RS10255	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E5Q10_RS10285	COG1476	TRANSCRIPTIONal
E5Q10_RS10320	COG2151	metal-sulfur cluster biosynthetic enzyme
E5Q10_RS10330	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E5Q10_RS10335	COG3959	Transketolase, thiamine diphosphate binding domain
E5Q10_RS10350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5Q10_RS10370	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E5Q10_RS10400	COG0383	alpha-mannosidase activity
E5Q10_RS10410	COG3537	Alpha-1,2-mannosidase
E5Q10_RS10435	COG0549	Belongs to the carbamate kinase family
E5Q10_RS10440	COG1288	antiporter activity
E5Q10_RS10445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5Q10_RS10475	COG1454	alcohol dehydrogenase
E5Q10_RS10480	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
E5Q10_RS10495	COG3716	PTS system mannose fructose sorbose family IID component
E5Q10_RS10505	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5Q10_RS10525	COG1070	Carbohydrate kinase
E5Q10_RS10535	COG0803	Belongs to the bacterial solute-binding protein 9 family
E5Q10_RS10535	COG3443	Belongs to the bacterial solute-binding protein 9 family
E5Q10_RS10540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E5Q10_RS10545	COG1121	(ABC) transporter
E5Q10_RS10550	COG1846	Transcriptional regulator
E5Q10_RS10555	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
E5Q10_RS10565	COG1696	Membrane protein involved in D-alanine export
E5Q10_RS10580	COG2211	Major facilitator Superfamily
E5Q10_RS10585	COG3344	reverse transcriptase
E5Q10_RS10610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E5Q10_RS10635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5Q10_RS10645	COG1755	Isoprenylcysteine carboxyl methyltransferase
E5Q10_RS10650	COG5002	protein histidine kinase activity
E5Q10_RS10655	COG0745	RESPONSE REGULATOR receiver
E5Q10_RS10675	COG4463	regulation of RNA biosynthetic process
E5Q10_RS10680	COG1116	anion transmembrane transporter activity
E5Q10_RS10685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5Q10_RS10690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5Q10_RS10710	COG0305	Participates in initiation and elongation during chromosome replication
E5Q10_RS10730	COG1040	competence protein
E5Q10_RS10735	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
E5Q10_RS10740	COG1739	Uncharacterized protein family UPF0029
E5Q10_RS10775	COG0052	Belongs to the universal ribosomal protein uS2 family
E5Q10_RS10780	COG3942	CHAP domain
E5Q10_RS10790	COG1792	Involved in formation and maintenance of cell shape
E5Q10_RS10795	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E5Q10_RS10800	COG1122	ATPase activity
E5Q10_RS10805	COG1122	ATPase activity
E5Q10_RS10810	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E5Q10_RS10820	COG0612	Peptidase, M16
E5Q10_RS10825	COG0612	Peptidase, M16
E5Q10_RS10830	COG2501	S4 domain
E5Q10_RS10840	COG0517	IMP dehydrogenase activity
E5Q10_RS10840	COG0516	GMP reductase activity
E5Q10_RS10845	COG0180	Tryptophanyl-tRNA synthetase
E5Q10_RS10850	COG0488	(ABC) transporter
E5Q10_RS10870	COG1511	domain protein
E5Q10_RS10915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5Q10_RS10920	COG1475	DNA binding