locus-tag	class	description
KZH43_RS00010	COG0592	DNA-directed DNA polymerase activity
KZH43_RS00020	COG0012	GTP binding
KZH43_RS00025	COG0193	aminoacyl-tRNA hydrolase activity
KZH43_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KZH43_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KZH43_RS00050	COG0037	tRNA processing
KZH43_RS00055	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KZH43_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KZH43_RS00130	COG0756	dUTP diphosphatase activity
KZH43_RS00140	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KZH43_RS00155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KZH43_RS00170	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KZH43_RS00170	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KZH43_RS00175	COG1832	CoA-binding protein
KZH43_RS00180	COG2855	membrane
KZH43_RS00185	COG0436	Aminotransferase
KZH43_RS00190	COG1381	Involved in DNA repair and RecF pathway recombination
KZH43_RS00200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KZH43_RS00220	COG2274	protein secretion by the type I secretion system
KZH43_RS00225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KZH43_RS00230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KZH43_RS00235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KZH43_RS00240	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KZH43_RS00245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KZH43_RS00250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KZH43_RS00260	COG0138	bifunctional purine biosynthesis protein purh
KZH43_RS00265	COG0151	Belongs to the GarS family
KZH43_RS00270	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KZH43_RS00285	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KZH43_RS00290	COG3064	Membrane
KZH43_RS00290	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KZH43_RS00290	COG3583	domain protein
KZH43_RS00305	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KZH43_RS00310	COG3715	PTS system
KZH43_RS00315	COG3716	PTS system mannose fructose sorbose family IID component
KZH43_RS00325	COG2222	sugar isomerase
KZH43_RS00335	COG2514	catechol 2,3-dioxygenase activity
KZH43_RS00340	COG1937	Protein conserved in bacteria
KZH43_RS00375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KZH43_RS00380	COG0569	domain protein
KZH43_RS00385	COG1215	transferase activity, transferring glycosyl groups
KZH43_RS00405	COG5002	protein histidine kinase activity
KZH43_RS00435	COG4209	transmembrane transport
KZH43_RS00440	COG0395	ABC-type sugar transport system, permease component
KZH43_RS00445	COG1653	transport
KZH43_RS00475	COG1695	Transcriptional regulator
KZH43_RS00500	COG0546	phosphoglycolate phosphatase activity
KZH43_RS00505	COG1760	l-serine dehydratase
KZH43_RS00510	COG1760	l-serine dehydratase
KZH43_RS00540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KZH43_RS00545	COG0137	argininosuccinate synthase activity
KZH43_RS00645	COG0482	sulfurtransferase activity
KZH43_RS00650	COG0494	nUDIX hydrolase
KZH43_RS00655	COG0445	tRNA wobble uridine modification
KZH43_RS00680	COG1214	PFAM Peptidase M22, glycoprotease
KZH43_RS00690	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KZH43_RS00710	COG0438	transferase activity, transferring glycosyl groups
KZH43_RS00740	COG1396	sequence-specific DNA binding
KZH43_RS00770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KZH43_RS00775	COG1464	Belongs to the NlpA lipoprotein family
KZH43_RS00780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KZH43_RS00785	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KZH43_RS00805	COG2972	Histidine kinase
KZH43_RS00810	COG2207	Transcriptional regulator
KZH43_RS00810	COG4753	response regulator
KZH43_RS00820	COG1780	Probably involved in ribonucleotide reductase function
KZH43_RS00850	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KZH43_RS00850	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KZH43_RS00870	COG2818	Glycosylase
KZH43_RS00895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KZH43_RS00900	COG0006	proline dipeptidase activity
KZH43_RS00905	COG1393	Belongs to the ArsC family
KZH43_RS00930	COG0285	dihydrofolate synthase activity
KZH43_RS00940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KZH43_RS00970	COG0602	queuosine metabolic process
KZH43_RS01005	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KZH43_RS01030	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KZH43_RS01070	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KZH43_RS01085	COG0201	protein transport
KZH43_RS01095	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KZH43_RS01100	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KZH43_RS01110	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KZH43_RS01115	COG0202	RNA polymerase activity
KZH43_RS01125	COG3830	Belongs to the UPF0237 family
KZH43_RS01145	COG3842	ATPase activity
KZH43_RS01160	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KZH43_RS01165	COG1349	DNA-binding transcription factor activity
KZH43_RS01175	COG1447	Phosphotransferase system cellobiose-specific component IIA
KZH43_RS01180	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KZH43_RS01185	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KZH43_RS01190	COG1882	Formate acetyltransferase
KZH43_RS01205	COG0495	leucyl-tRNA aminoacylation
KZH43_RS01235	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KZH43_RS01240	COG4589	Belongs to the CDS family
KZH43_RS01245	COG0750	zinc metalloprotease
KZH43_RS01250	COG0442	prolyl-tRNA aminoacylation
KZH43_RS01255	COG2723	6-phospho-beta-galactosidase activity
KZH43_RS01260	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KZH43_RS01270	COG1523	belongs to the glycosyl hydrolase 13 family
KZH43_RS01290	COG2176	DNA-directed DNA polymerase activity
KZH43_RS01310	COG2309	aminopeptidase activity
KZH43_RS01315	COG2261	transglycosylase associated protein
KZH43_RS01320	COG1187	pseudouridine synthase activity
KZH43_RS01325	COG3579	cysteine-type endopeptidase activity
KZH43_RS01330	COG3716	PTS system mannose fructose sorbose family IID component
KZH43_RS01335	COG3715	PTS system
KZH43_RS01345	COG1064	alcohol dehydrogenase
KZH43_RS01350	COG0561	phosphatase activity
KZH43_RS01355	COG2252	PERMEase
KZH43_RS01365	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KZH43_RS01370	COG0285	dihydrofolate synthase activity
KZH43_RS01375	COG0302	gtp cyclohydrolase
KZH43_RS01380	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KZH43_RS01380	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KZH43_RS01390	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KZH43_RS01410	COG2723	6-phospho-beta-galactosidase activity
KZH43_RS01425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KZH43_RS01425	COG3711	transcriptional antiterminator
KZH43_RS01440	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KZH43_RS01455	COG0386	Belongs to the glutathione peroxidase family
KZH43_RS01460	COG5492	domain, Protein
KZH43_RS01485	COG1028	Short-chain dehydrogenase reductase Sdr
KZH43_RS01495	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
KZH43_RS01500	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KZH43_RS01505	COG3715	PTS system
KZH43_RS01510	COG3716	PTS system mannose fructose sorbose family IID component
KZH43_RS01525	COG1609	Transcriptional regulator
KZH43_RS01550	COG4839	cell division protein FtsL
KZH43_RS01555	COG0768	penicillin binding
KZH43_RS01560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KZH43_RS01575	COG4868	Belongs to the UPF0371 family
KZH43_RS01580	COG0366	Alpha amylase catalytic
KZH43_RS01585	COG4166	transmembrane transport
KZH43_RS01655	COG0366	Alpha amylase catalytic
KZH43_RS01660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KZH43_RS01685	COG0116	Belongs to the methyltransferase superfamily
KZH43_RS01695	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KZH43_RS01700	COG0745	RESPONSE REGULATOR receiver
KZH43_RS01725	COG1304	FMN binding
KZH43_RS01735	COG4585	Histidine kinase
KZH43_RS01740	COG2197	response regulator
KZH43_RS01780	COG2213	PTS system mannitol-specific
KZH43_RS01785	COG3711	transcriptional antiterminator
KZH43_RS01790	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KZH43_RS01795	COG0246	Mannitol dehydrogenase
KZH43_RS01800	COG0544	peptidyl-prolyl cis-trans isomerase activity
KZH43_RS01805	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KZH43_RS01810	COG0681	Belongs to the peptidase S26 family
KZH43_RS01835	COG1115	amino acid carrier protein
KZH43_RS01850	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KZH43_RS01860	COG0527	aspartate kinase activity
KZH43_RS01865	COG1024	Enoyl-CoA hydratase
KZH43_RS01880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KZH43_RS01890	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KZH43_RS01895	COG1028	Short-chain dehydrogenase reductase Sdr
KZH43_RS01900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KZH43_RS01915	COG0439	Biotin carboxylase
KZH43_RS01920	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KZH43_RS01955	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KZH43_RS01980	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KZH43_RS01990	COG1461	Dihydroxyacetone kinase
KZH43_RS01995	COG0028	Belongs to the TPP enzyme family
KZH43_RS02000	COG0440	acetolactate synthase activity
KZH43_RS02020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KZH43_RS02035	COG0765	amino acid transport
KZH43_RS02055	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KZH43_RS02060	COG1882	Formate acetyltransferase
KZH43_RS02080	COG1846	Transcriptional regulator
KZH43_RS02080	COG1940	carbohydrate kinase activity
KZH43_RS02085	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KZH43_RS02095	COG1447	Phosphotransferase system cellobiose-specific component IIA
KZH43_RS02100	COG2723	6-phospho-beta-galactosidase activity
KZH43_RS02105	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KZH43_RS02105	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KZH43_RS02110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KZH43_RS02115	COG0569	domain protein
KZH43_RS02135	COG1122	ATPase activity
KZH43_RS02150	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
KZH43_RS02155	COG0671	phosphoesterase, PA-phosphatase related
KZH43_RS02165	COG1247	-acetyltransferase
KZH43_RS02175	COG0504	CTP synthase activity
KZH43_RS02190	COG0126	phosphoglycerate kinase activity
KZH43_RS02200	COG0789	Transcriptional regulator
KZH43_RS02205	COG0174	glutamine synthetase
KZH43_RS02220	COG4974	Belongs to the 'phage' integrase family
KZH43_RS02230	COG0732	type I restriction modification DNA specificity domain
KZH43_RS02255	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KZH43_RS02270	COG0484	heat shock protein binding
KZH43_RS02280	COG0537	adenosine 5'-monophosphoramidase activity
KZH43_RS02285	COG1131	(ABC) transporter
KZH43_RS02310	COG3290	protein histidine kinase activity
KZH43_RS02345	COG1266	CAAX protease self-immunity
KZH43_RS02365	COG0195	Participates in both transcription termination and antitermination
KZH43_RS02370	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KZH43_RS02385	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KZH43_RS02435	COG0519	Catalyzes the synthesis of GMP from XMP
KZH43_RS02445	COG0525	valine-tRNA ligase activity
KZH43_RS02470	COG3711	transcriptional antiterminator
KZH43_RS02475	COG2190	(PTS) system
KZH43_RS02475	COG1263	PTS System
KZH43_RS02475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KZH43_RS02490	COG0456	acetyltransferase
KZH43_RS02495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KZH43_RS02495	COG0072	phenylalanine-tRNA ligase activity
KZH43_RS02510	COG3620	sequence-specific DNA binding
KZH43_RS02515	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KZH43_RS02525	COG1185	polyribonucleotide nucleotidyltransferase activity
KZH43_RS02530	COG1045	serine acetyltransferase
KZH43_RS02540	COG0215	cysteine-tRNA ligase activity
KZH43_RS02545	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
KZH43_RS02565	COG0577	efflux transmembrane transporter activity
KZH43_RS02570	COG1136	(ABC) transporter
KZH43_RS02575	COG0577	efflux transmembrane transporter activity
KZH43_RS02585	COG0745	RESPONSE REGULATOR receiver
KZH43_RS02590	COG5002	protein histidine kinase activity
KZH43_RS02595	COG0191	fructose-bisphosphate aldolase activity
KZH43_RS02600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KZH43_RS02605	COG0765	amino acid transport
KZH43_RS02610	COG0765	amino acid transport
KZH43_RS02615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KZH43_RS02625	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KZH43_RS02625	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KZH43_RS02665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KZH43_RS02680	COG1573	uracil-dna glycosylase
KZH43_RS02695	COG1114	Component of the transport system for branched-chain amino acids
KZH43_RS02700	COG1363	Peptidase, m42
KZH43_RS02740	COG4555	ABC transporter
KZH43_RS02770	COG1404	Belongs to the peptidase S8 family
KZH43_RS02785	COG3775	system Galactitol-specific IIC component
KZH43_RS02790	COG3250	beta-galactosidase activity
KZH43_RS02810	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KZH43_RS02830	COG0785	Cytochrome C biogenesis protein
KZH43_RS02835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KZH43_RS02840	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KZH43_RS02840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KZH43_RS02845	COG4753	response regulator
KZH43_RS02845	COG2207	Transcriptional regulator
KZH43_RS02850	COG2972	Histidine kinase
KZH43_RS02855	COG4475	Protein of unknown function (DUF436)
KZH43_RS02860	COG3064	Membrane
KZH43_RS02865	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KZH43_RS02880	COG1940	carbohydrate kinase activity
KZH43_RS02900	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KZH43_RS02905	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
KZH43_RS02915	COG0300	oxidoreductase activity
KZH43_RS02930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KZH43_RS02940	COG1187	pseudouridine synthase activity
KZH43_RS02945	COG1217	gtp-binding protein TYPA
KZH43_RS02965	COG1136	(ABC) transporter
KZH43_RS02970	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KZH43_RS02975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KZH43_RS02980	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KZH43_RS03015	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KZH43_RS03040	COG1131	(ABC) transporter
KZH43_RS03045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KZH43_RS03050	COG1126	abc transporter atp-binding protein
KZH43_RS03055	COG4215	(ABC) transporter
KZH43_RS03065	COG1304	FMN binding
KZH43_RS03075	COG1304	FMN binding
KZH43_RS03085	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
KZH43_RS03090	COG0352	thiamine-phosphate diphosphorylase activity
KZH43_RS03100	COG4172	Belongs to the ABC transporter superfamily
KZH43_RS03110	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KZH43_RS03120	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
KZH43_RS03125	COG0352	thiamine-phosphate diphosphorylase activity
KZH43_RS03145	COG2217	Heavy metal translocating P-type atpase
KZH43_RS03150	COG0028	Belongs to the TPP enzyme family
KZH43_RS03170	COG1482	cell wall glycoprotein biosynthetic process
KZH43_RS03175	COG0733	neurotransmitter:sodium symporter activity
KZH43_RS03190	COG2081	HI0933 family
KZH43_RS03195	COG1307	EDD domain protein, DegV family
KZH43_RS03205	COG2131	deaminase
KZH43_RS03210	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KZH43_RS03250	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KZH43_RS03250	COG0617	tRNA 3'-terminal CCA addition
KZH43_RS03250	COG0517	IMP dehydrogenase activity
KZH43_RS03260	COG2884	Cell division ATP-binding protein ftsE
KZH43_RS03265	COG2177	Part of the ABC transporter FtsEX involved in
KZH43_RS03270	COG1263	PTS System
KZH43_RS03270	COG2190	(PTS) system
KZH43_RS03270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KZH43_RS03280	COG0513	Belongs to the DEAD box helicase family
KZH43_RS03290	COG0167	dihydroorotate dehydrogenase activity
KZH43_RS03300	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KZH43_RS03305	COG4470	Protein conserved in bacteria
KZH43_RS03310	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KZH43_RS03320	COG0488	(ABC) transporter
KZH43_RS03345	COG1837	Belongs to the UPF0109 family
KZH43_RS03370	COG1328	CTP reductase activity
KZH43_RS03370	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KZH43_RS03380	COG4443	Transcriptional Coactivator p15 (PC4)
KZH43_RS03390	COG1268	BioY protein
KZH43_RS03395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KZH43_RS03400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KZH43_RS03405	COG1136	(ABC) transporter
KZH43_RS03410	COG0577	efflux transmembrane transporter activity
KZH43_RS03415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KZH43_RS03415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KZH43_RS03435	COG4989	oxidoreductase activity
KZH43_RS03445	COG1028	Short-chain dehydrogenase reductase Sdr
KZH43_RS03475	COG0745	RESPONSE REGULATOR receiver
KZH43_RS03480	COG5002	protein histidine kinase activity
KZH43_RS03500	COG0772	Belongs to the SEDS family
KZH43_RS03505	COG0693	protein deglycase activity
KZH43_RS03515	COG0187	DNA topoisomerase II activity
KZH43_RS03540	COG0494	nUDIX hydrolase
KZH43_RS03550	COG0542	response to heat
KZH43_RS03555	COG4703	Protein of unknown function (DUF1797)
KZH43_RS03560	COG0765	amino acid transport
KZH43_RS03565	COG1126	abc transporter atp-binding protein
KZH43_RS03570	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KZH43_RS03575	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KZH43_RS03585	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
KZH43_RS03595	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KZH43_RS03640	COG2813	Specifically methylates the guanine in position
KZH43_RS03645	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KZH43_RS03650	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KZH43_RS03655	COG0295	cytidine deaminase activity
KZH43_RS03660	COG1744	ABC transporter substrate-binding protein PnrA-like
KZH43_RS03670	COG4603	Belongs to the binding-protein-dependent transport system permease family
KZH43_RS03675	COG1079	Belongs to the binding-protein-dependent transport system permease family
KZH43_RS03690	COG0187	DNA topoisomerase II activity
KZH43_RS03695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KZH43_RS03700	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KZH43_RS03705	COG4166	transmembrane transport
KZH43_RS03740	COG0539	negative regulation of cytoplasmic translation
KZH43_RS03750	COG1956	GAF domain-containing protein
KZH43_RS03755	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KZH43_RS03770	COG0719	Fe-S assembly protein
KZH43_RS03775	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KZH43_RS03785	COG0719	Fe-S assembly protein
KZH43_RS03790	COG1686	Belongs to the peptidase S11 family
KZH43_RS03795	COG0628	permease
KZH43_RS03810	COG1349	DNA-binding transcription factor activity
KZH43_RS03815	COG1105	Belongs to the carbohydrate kinase PfkB family
KZH43_RS03820	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KZH43_RS03820	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KZH43_RS03820	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KZH43_RS03825	COG1674	ftsk spoiiie
KZH43_RS03825	COG0697	spore germination
KZH43_RS03835	COG1104	cysteine desulfurase activity
KZH43_RS03840	COG0301	tRNA thio-modification
KZH43_RS03870	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
KZH43_RS03880	COG1438	arginine binding
KZH43_RS03885	COG2936	dipeptidyl-peptidase activity
KZH43_RS03895	COG0205	6-phosphofructokinase activity
KZH43_RS03900	COG0469	pyruvate kinase activity
KZH43_RS03935	COG3689	TIGRFAM TIGR03943 family protein
KZH43_RS03940	COG0701	Predicted permease
KZH43_RS03950	COG3955	Domain of unknown function (DUF1919)
KZH43_RS03955	COG2183	response to ionizing radiation
KZH43_RS03975	COG1136	(ABC) transporter
KZH43_RS03980	COG0577	efflux transmembrane transporter activity
KZH43_RS03995	COG1982	Orn Lys Arg decarboxylase major
KZH43_RS04005	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KZH43_RS04020	COG2957	Belongs to the agmatine deiminase family
KZH43_RS04025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KZH43_RS04030	COG0561	phosphatase activity
KZH43_RS04050	COG0583	DNA-binding transcription factor activity
KZH43_RS04055	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KZH43_RS04060	COG0564	pseudouridine synthase activity
KZH43_RS04065	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KZH43_RS04080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KZH43_RS04090	COG0470	DNA polymerase III
KZH43_RS04135	COG0528	UMP kinase activity
KZH43_RS04140	COG0233	cytoplasmic translational termination
KZH43_RS04145	COG2996	Protein conserved in bacteria
KZH43_RS04155	COG1702	phosphate starvation-inducible protein PhoH
KZH43_RS04190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KZH43_RS04195	COG1596	polysaccharide export
KZH43_RS04195	COG1555	photosystem II stabilization
KZH43_RS04200	COG2333	competence protein COMEC
KZH43_RS04200	COG0658	competence protein
KZH43_RS04240	COG0543	2 iron, 2 sulfur cluster binding
KZH43_RS04245	COG0167	dihydroorotate dehydrogenase activity
KZH43_RS04250	COG5263	repeat protein
KZH43_RS04250	COG4193	domain, Protein
KZH43_RS04255	COG1293	RNA-binding protein homologous to eukaryotic snRNP
KZH43_RS04265	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KZH43_RS04275	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KZH43_RS04280	COG0237	dephospho-CoA kinase activity
KZH43_RS04285	COG2814	Major facilitator Superfamily
KZH43_RS04300	COG0557	exoribonuclease II activity
KZH43_RS04310	COG3615	Tellurite resistance protein tehB
KZH43_RS04310	COG0500	methyltransferase
KZH43_RS04325	COG4122	O-methyltransferase activity
KZH43_RS04350	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KZH43_RS04365	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KZH43_RS04370	COG0494	nUDIX hydrolase
KZH43_RS04380	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KZH43_RS04390	COG2176	DNA-directed DNA polymerase activity
KZH43_RS04395	COG0584	glycerophosphoryl diester phosphodiesterase
KZH43_RS04415	COG0785	Cytochrome C biogenesis protein
KZH43_RS04420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KZH43_RS04425	COG0531	amino acid
KZH43_RS04430	COG0803	Belongs to the bacterial solute-binding protein 9 family
KZH43_RS04430	COG3443	Belongs to the bacterial solute-binding protein 9 family
KZH43_RS04465	COG2195	Cleaves the N-terminal amino acid of tripeptides
KZH43_RS04470	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KZH43_RS04475	COG1970	mechanosensitive ion channel activity
KZH43_RS04485	COG4708	membrane
KZH43_RS04495	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KZH43_RS04500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KZH43_RS04505	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KZH43_RS04510	COG1942	4-Oxalocrotonate Tautomerase
KZH43_RS04515	COG1435	thymidine kinase activity
KZH43_RS04530	COG2890	protein-(glutamine-N5) methyltransferase activity
KZH43_RS04545	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KZH43_RS04555	COG0741	lytic transglycosylase activity
KZH43_RS04565	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KZH43_RS04585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KZH43_RS04590	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KZH43_RS04640	COG1597	lipid kinase activity
KZH43_RS04645	COG0366	Alpha amylase catalytic
KZH43_RS04660	COG1396	sequence-specific DNA binding
KZH43_RS04665	COG0542	response to heat
KZH43_RS04670	COG0613	PHP domain protein
KZH43_RS04725	COG0318	PFAM AMP-dependent synthetase and ligase
KZH43_RS04765	COG0772	Belongs to the SEDS family
KZH43_RS04770	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
KZH43_RS04790	COG0358	DNA primase activity
KZH43_RS04795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KZH43_RS04800	COG2151	metal-sulfur cluster biosynthetic enzyme
KZH43_RS04805	COG0438	transferase activity, transferring glycosyl groups
KZH43_RS04810	COG0438	transferase activity, transferring glycosyl groups
KZH43_RS04825	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KZH43_RS04840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KZH43_RS04850	COG4109	DRTGG domain
KZH43_RS04855	COG0024	Methionine aminopeptidase
KZH43_RS04865	COG0210	DNA helicase
KZH43_RS04870	COG2003	Belongs to the UPF0758 family
KZH43_RS04875	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KZH43_RS04880	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KZH43_RS04895	COG1104	cysteine desulfurase activity
KZH43_RS04900	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KZH43_RS04910	COG2357	RelA SpoT domain protein
KZH43_RS04920	COG0564	pseudouridine synthase activity
KZH43_RS04925	COG0280	phosphate acetyltransferase
KZH43_RS04965	COG0196	riboflavin kinase activity
KZH43_RS04970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KZH43_RS04975	COG1307	EDD domain protein, DegV family
KZH43_RS04985	COG0488	(ABC) transporter
KZH43_RS05000	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KZH43_RS05005	COG1523	belongs to the glycosyl hydrolase 13 family
KZH43_RS05010	COG1012	belongs to the aldehyde dehydrogenase family
KZH43_RS05015	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KZH43_RS05020	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KZH43_RS05025	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KZH43_RS05030	COG0297	glycogen (starch) synthase activity
KZH43_RS05055	COG0582	viral genome integration into host DNA
KZH43_RS05070	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
KZH43_RS05075	COG1074	ATP-dependent DNA helicase activity
KZH43_RS05085	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
KZH43_RS05085	COG3583	domain protein
KZH43_RS05095	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KZH43_RS05100	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KZH43_RS05115	COG0095	Lipoate-protein ligase
KZH43_RS05120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KZH43_RS05125	COG0508	dehydrogenase complex catalyzes the overall conversion of
KZH43_RS05130	COG0022	dehydrogenase e1 component
KZH43_RS05135	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KZH43_RS05140	COG0534	Mate efflux family protein
KZH43_RS05150	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KZH43_RS05155	COG1051	belongs to the nudix hydrolase family
KZH43_RS05170	COG1011	Hydrolase
KZH43_RS05190	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KZH43_RS05195	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KZH43_RS05200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KZH43_RS05205	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KZH43_RS05220	COG2723	6-phospho-beta-galactosidase activity
KZH43_RS05235	COG3711	transcriptional antiterminator
KZH43_RS05240	COG3684	Belongs to the aldolase LacD family
KZH43_RS05290	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KZH43_RS05295	COG0497	DNA recombination
KZH43_RS05300	COG1438	arginine binding
KZH43_RS05305	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KZH43_RS05320	COG1570	exodeoxyribonuclease VII activity
KZH43_RS05335	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KZH43_RS05360	COG3764	Sortase (surface protein transpeptidase)
KZH43_RS05365	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KZH43_RS05395	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KZH43_RS05400	COG5002	protein histidine kinase activity
KZH43_RS05405	COG0745	RESPONSE REGULATOR receiver
KZH43_RS05410	COG1194	a g-specific adenine glycosylase
KZH43_RS05425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KZH43_RS05430	COG4684	Psort location CytoplasmicMembrane, score
KZH43_RS05440	COG1827	regulation of RNA biosynthetic process
KZH43_RS05460	COG0556	nucleotide-excision repair
KZH43_RS05470	COG0765	amino acid transport
KZH43_RS05475	COG1126	abc transporter atp-binding protein
KZH43_RS05480	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KZH43_RS05485	COG0552	protein localization to endoplasmic reticulum
KZH43_RS05490	COG0561	phosphatase activity
KZH43_RS05495	COG0561	phosphatase activity
KZH43_RS05500	COG1196	nuclear chromosome segregation
KZH43_RS05545	COG0066	3-isopropylmalate dehydratase activity
KZH43_RS05555	COG0473	3-isopropylmalate dehydrogenase activity
KZH43_RS05570	COG3142	Participates in the control of copper homeostasis
KZH43_RS05575	COG2832	Protein of unknown function (DUF454)
KZH43_RS05580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KZH43_RS05590	COG0758	DNA mediated transformation
KZH43_RS05595	COG4750	Nucleotidyl transferase
KZH43_RS05610	COG1063	alcohol dehydrogenase
KZH43_RS05615	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KZH43_RS05625	COG3475	LICD family
KZH43_RS05630	COG3475	LICD family
KZH43_RS05640	COG0505	Belongs to the CarA family
KZH43_RS05645	COG0540	Belongs to the ATCase OTCase family
KZH43_RS05655	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KZH43_RS05670	COG0488	(ABC) transporter
KZH43_RS05680	COG1704	LemA family
KZH43_RS05695	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KZH43_RS05710	COG1078	dGTPase activity
KZH43_RS05725	COG0335	large ribosomal subunit rRNA binding
KZH43_RS05730	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KZH43_RS05735	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KZH43_RS05740	COG1605	Chorismate mutase
KZH43_RS05740	COG0077	Prephenate dehydratase
KZH43_RS05745	COG0716	FMN binding
KZH43_RS05750	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KZH43_RS05775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KZH43_RS05805	COG0295	cytidine deaminase activity
KZH43_RS05810	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KZH43_RS05825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KZH43_RS05830	COG0601	transmembrane transport
KZH43_RS05845	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
KZH43_RS05885	COG1770	oligopeptidase
KZH43_RS05890	COG0515	serine threonine protein kinase
KZH43_RS05940	COG0402	S-adenosylhomocysteine deaminase activity
KZH43_RS05955	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KZH43_RS05955	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KZH43_RS05975	COG4862	establishment of competence for transformation
KZH43_RS05990	COG1215	transferase activity, transferring glycosyl groups
KZH43_RS06000	COG3475	LICD family
KZH43_RS06010	COG0077	Prephenate dehydratase
KZH43_RS06015	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KZH43_RS06020	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KZH43_RS06030	COG0287	Prephenate dehydrogenase
KZH43_RS06055	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KZH43_RS06065	COG1131	(ABC) transporter
KZH43_RS06075	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KZH43_RS06105	COG3842	ATPase activity
KZH43_RS06120	COG3527	Alpha-acetolactate decarboxylase
KZH43_RS06125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KZH43_RS06130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KZH43_RS06135	COG0704	Plays a role in the regulation of phosphate uptake
KZH43_RS06140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KZH43_RS06145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KZH43_RS06150	COG0581	inorganic phosphate transmembrane transporter activity
KZH43_RS06155	COG0573	inorganic phosphate transmembrane transporter activity
KZH43_RS06160	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KZH43_RS06165	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KZH43_RS06165	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
KZH43_RS06170	COG0483	inositol monophosphate 1-phosphatase activity
KZH43_RS06180	COG1393	Belongs to the ArsC family
KZH43_RS06190	COG0647	UMP catabolic process
KZH43_RS06200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KZH43_RS06235	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KZH43_RS06245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KZH43_RS06255	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KZH43_RS06275	COG1131	(ABC) transporter
KZH43_RS06280	COG0826	peptidase U32
KZH43_RS06310	COG1132	(ABC) transporter
KZH43_RS06325	COG1129	ABC transporter
KZH43_RS06365	COG2188	Transcriptional regulator
KZH43_RS06370	COG0697	spore germination
KZH43_RS06375	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KZH43_RS06390	COG0561	phosphatase activity
KZH43_RS06410	COG0492	ferredoxin-NADP+ reductase activity
KZH43_RS06420	COG1126	abc transporter atp-binding protein
KZH43_RS06430	COG1393	Belongs to the ArsC family
KZH43_RS06435	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KZH43_RS06455	COG1272	protein, Hemolysin III
KZH43_RS06460	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
KZH43_RS06485	COG0431	NADPH-dependent FMN reductase
KZH43_RS06485	COG1053	succinate dehydrogenase
KZH43_RS06485	COG3976	FMN-binding domain protein
KZH43_RS06495	COG0751	glycine-tRNA ligase activity
KZH43_RS06500	COG0752	glycyl-tRNA synthetase alpha subunit
KZH43_RS06510	COG0656	L-ascorbic acid biosynthetic process
KZH43_RS06515	COG0726	polysaccharide deacetylase
KZH43_RS06560	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KZH43_RS06585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KZH43_RS06595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KZH43_RS06600	COG1126	abc transporter atp-binding protein
KZH43_RS06615	COG0628	permease
KZH43_RS06620	COG2706	6-phosphogluconolactonase activity
KZH43_RS06635	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KZH43_RS06680	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KZH43_RS06705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KZH43_RS06710	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KZH43_RS06715	COG0626	cystathionine gamma-synthase activity
KZH43_RS06725	COG4166	transmembrane transport
KZH43_RS06730	COG2244	polysaccharide biosynthetic process
KZH43_RS06735	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KZH43_RS06760	COG2827	Endonuclease containing a URI domain
KZH43_RS06765	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KZH43_RS06770	COG1098	S1 RNA binding domain
KZH43_RS06780	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KZH43_RS06785	COG0629	single-stranded DNA binding
KZH43_RS06795	COG0017	Asparaginyl-tRNA synthetase
KZH43_RS06805	COG0436	Aminotransferase
KZH43_RS06825	COG3711	transcriptional antiterminator
KZH43_RS06845	COG0242	peptide deformylase activity
KZH43_RS06850	COG0625	glutathione transferase activity
KZH43_RS06860	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KZH43_RS06865	COG0488	(ABC) transporter
KZH43_RS06870	COG0617	tRNA 3'-terminal CCA addition
KZH43_RS06880	COG1307	EDD domain protein, DegV family
KZH43_RS06890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KZH43_RS06900	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KZH43_RS06905	COG0492	ferredoxin-NADP+ reductase activity
KZH43_RS06910	COG1481	regulation of sporulation
KZH43_RS06915	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KZH43_RS06920	COG1660	Displays ATPase and GTPase activities
KZH43_RS06925	COG0251	oxidation-reduction process
KZH43_RS06945	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KZH43_RS06955	COG4193	domain, Protein
KZH43_RS06955	COG5263	repeat protein
KZH43_RS06965	COG3935	DnaD domain protein
KZH43_RS06980	COG2226	methyltransferase
KZH43_RS06990	COG3842	ATPase activity
KZH43_RS07000	COG1335	isochorismatase
KZH43_RS07005	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
KZH43_RS07010	COG0513	Belongs to the DEAD box helicase family
KZH43_RS07015	COG2223	nitrite transmembrane transporter activity
KZH43_RS07025	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KZH43_RS07030	COG3442	glutamine amidotransferase
KZH43_RS07035	COG0006	proline dipeptidase activity
KZH43_RS07050	COG4720	Psort location CytoplasmicMembrane, score
KZH43_RS07055	COG0351	phosphomethylpyrimidine kinase
KZH43_RS07075	COG2824	Alkylphosphonate utilization operon protein PhnA
KZH43_RS07095	COG0463	Glycosyl transferase, family 2
KZH43_RS07100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KZH43_RS07105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KZH43_RS07110	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KZH43_RS07115	COG2384	SAM-dependent methyltransferase
KZH43_RS07120	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KZH43_RS07125	COG0204	Acyl-transferase
KZH43_RS07140	COG2910	NAD(P)H-binding
KZH43_RS07160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KZH43_RS07165	COG5002	protein histidine kinase activity
KZH43_RS07170	COG0745	RESPONSE REGULATOR receiver
KZH43_RS07185	COG1959	2 iron, 2 sulfur cluster binding
KZH43_RS07245	COG3590	peptidase
KZH43_RS07260	COG0803	Belongs to the bacterial solute-binding protein 9 family
KZH43_RS07265	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KZH43_RS07275	COG0577	efflux transmembrane transporter activity
KZH43_RS07275	COG1136	(ABC) transporter
KZH43_RS07295	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KZH43_RS07300	COG3599	regulation of cell shape
KZH43_RS07320	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KZH43_RS07340	COG1051	belongs to the nudix hydrolase family
KZH43_RS07345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KZH43_RS07350	COG1181	Belongs to the D-alanine--D-alanine ligase family
KZH43_RS07360	COG0768	penicillin binding
KZH43_RS07390	COG2731	YhcH YjgK YiaL family protein
KZH43_RS07395	COG0395	ABC-type sugar transport system, permease component
KZH43_RS07400	COG1175	transmembrane transport
KZH43_RS07410	COG2190	(PTS) system
KZH43_RS07410	COG1263	PTS System
KZH43_RS07410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KZH43_RS07420	COG0673	inositol 2-dehydrogenase activity
KZH43_RS07425	COG4409	exo-alpha-(2->6)-sialidase activity
KZH43_RS07435	COG1175	transmembrane transport
KZH43_RS07440	COG1653	transport
KZH43_RS07465	COG3458	cephalosporin-C deacetylase activity
KZH43_RS07470	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KZH43_RS07485	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KZH43_RS07490	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KZH43_RS07495	COG0653	protein targeting
KZH43_RS07505	COG1131	(ABC) transporter
KZH43_RS07550	COG1484	DNA-dependent DNA replication
KZH43_RS07565	COG1725	Transcriptional regulator
KZH43_RS07570	COG1131	(ABC) transporter
KZH43_RS07580	COG1668	transmembrane transport
KZH43_RS07585	COG4152	abc transporter atp-binding protein
KZH43_RS07605	COG1940	carbohydrate kinase activity
KZH43_RS07610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KZH43_RS07610	COG1263	PTS System
KZH43_RS07610	COG2190	(PTS) system
KZH43_RS07615	COG1621	beta-fructofuranosidase activity
KZH43_RS07620	COG1609	Transcriptional regulator
KZH43_RS07630	COG3425	synthase
KZH43_RS07655	COG2815	serine threonine protein kinase
KZH43_RS07655	COG0515	serine threonine protein kinase
KZH43_RS07660	COG0631	protein serine/threonine phosphatase activity
KZH43_RS07665	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KZH43_RS07665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KZH43_RS07675	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KZH43_RS07685	COG0194	GDP metabolic process
KZH43_RS07695	COG4115	mRNA cleavage
KZH43_RS07705	COG1323	Belongs to the UPF0348 family
KZH43_RS07710	COG2226	methyltransferase
KZH43_RS07715	COG0799	negative regulation of ribosome biogenesis
KZH43_RS07725	COG1713	HD superfamily hydrolase involved in NAD metabolism
KZH43_RS07730	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KZH43_RS07735	COG1534	Rna-binding protein
KZH43_RS07740	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KZH43_RS07755	COG0668	transmembrane transport
KZH43_RS07780	COG3118	belongs to the thioredoxin family
KZH43_RS07785	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KZH43_RS07795	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KZH43_RS07805	COG1164	Oligoendopeptidase f
KZH43_RS07810	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KZH43_RS07815	COG2264	protein methyltransferase activity
KZH43_RS07820	COG1051	belongs to the nudix hydrolase family
KZH43_RS07855	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KZH43_RS07865	COG1621	beta-fructofuranosidase activity
KZH43_RS07870	COG0395	ABC-type sugar transport system, permease component
KZH43_RS07875	COG1175	transmembrane transport
KZH43_RS07885	COG1609	Transcriptional regulator
KZH43_RS07890	COG3711	transcriptional antiterminator
KZH43_RS07915	COG3237	CsbD-like
KZH43_RS07950	COG0159	tryptophan synthase activity
KZH43_RS07955	COG0133	tryptophan synthase activity
KZH43_RS07960	COG0135	phosphoribosylanthranilate isomerase activity
KZH43_RS07975	COG0512	Glutamine amidotransferase of anthranilate synthase
KZH43_RS07980	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KZH43_RS08005	COG1285	pathogenesis
KZH43_RS08010	COG1178	ABC-type Fe3 transport system permease component
KZH43_RS08030	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KZH43_RS08035	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
KZH43_RS08040	COG0704	Plays a role in the regulation of phosphate uptake
KZH43_RS08055	COG5434	Belongs to the glycosyl hydrolase 28 family
KZH43_RS08060	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KZH43_RS08065	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KZH43_RS08070	COG1132	(ABC) transporter
KZH43_RS08075	COG1132	(ABC) transporter
KZH43_RS08090	COG0708	Exodeoxyribonuclease III
KZH43_RS08105	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KZH43_RS08110	COG2233	PERMEase
KZH43_RS08130	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
KZH43_RS08135	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KZH43_RS08140	COG1609	Transcriptional regulator
KZH43_RS08145	COG1063	alcohol dehydrogenase
KZH43_RS08150	COG0789	Transcriptional regulator
KZH43_RS08155	COG1230	cation diffusion facilitator family transporter
KZH43_RS08165	COG3201	nicotinamide mononucleotide transporter
KZH43_RS08175	COG1174	glycine betaine transport
KZH43_RS08200	COG1363	Peptidase, m42
KZH43_RS08210	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KZH43_RS08215	COG4605	iron ion homeostasis
KZH43_RS08220	COG4604	ABC transporter, ATP-binding protein
KZH43_RS08225	COG4607	ABC-type enterochelin transport system periplasmic component
KZH43_RS08235	COG1187	pseudouridine synthase activity
KZH43_RS08255	COG0517	IMP dehydrogenase activity
KZH43_RS08265	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KZH43_RS08280	COG0366	Alpha amylase catalytic
KZH43_RS08285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KZH43_RS08285	COG1263	PTS System
KZH43_RS08290	COG2188	Transcriptional regulator
KZH43_RS08300	COG4608	Belongs to the ABC transporter superfamily
KZH43_RS08305	COG0444	Belongs to the ABC transporter superfamily
KZH43_RS08310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KZH43_RS08315	COG0601	transmembrane transport
KZH43_RS08320	COG4166	transmembrane transport
KZH43_RS08330	COG0366	Alpha amylase catalytic
KZH43_RS08340	COG0395	ABC-type sugar transport system, permease component
KZH43_RS08345	COG1175	transmembrane transport
KZH43_RS08350	COG1653	transport
KZH43_RS08355	COG3345	alpha-galactosidase
KZH43_RS08360	COG2207	Transcriptional regulator
KZH43_RS08365	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KZH43_RS08365	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KZH43_RS08485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KZH43_RS08515	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KZH43_RS08525	COG4221	oxidoreductase activity
KZH43_RS08530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KZH43_RS08535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KZH43_RS08655	COG5263	repeat protein
KZH43_RS08655	COG5632	N-Acetylmuramoyl-L-alanine amidase
KZH43_RS08670	COG1058	Belongs to the CinA family
KZH43_RS08670	COG1546	Belongs to the CinA family
KZH43_RS08675	COG1316	TRANSCRIPTIONal
KZH43_RS08685	COG0802	atpase or kinase
KZH43_RS08740	COG1136	(ABC) transporter
KZH43_RS08765	COG1253	flavin adenine dinucleotide binding
KZH43_RS08780	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KZH43_RS08790	COG3480	Lon protease (S16) C-terminal proteolytic domain
KZH43_RS08795	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KZH43_RS08800	COG0742	ribosomal rna small subunit methyltransferase
KZH43_RS08805	COG2502	aspartate--ammonia ligase
KZH43_RS08815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KZH43_RS08820	COG1254	Belongs to the acylphosphatase family
KZH43_RS08825	COG0706	membrane insertase activity
KZH43_RS08830	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KZH43_RS08840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KZH43_RS08855	COG1564	THIamine pyrophosphokinase
KZH43_RS08865	COG1162	GTPase activity
KZH43_RS08870	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KZH43_RS08895	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KZH43_RS08900	COG0084	hydrolase, TatD family'
KZH43_RS08915	COG0436	Aminotransferase
KZH43_RS08925	COG0589	response to stress
KZH43_RS08930	COG0561	phosphatase activity
KZH43_RS08935	COG0252	asparaginase activity
KZH43_RS08945	COG1609	Transcriptional regulator
KZH43_RS08950	COG2197	response regulator
KZH43_RS08955	COG4585	Histidine kinase
KZH43_RS08960	COG0842	Transport permease protein
KZH43_RS08965	COG1131	(ABC) transporter
KZH43_RS09065	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KZH43_RS09070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KZH43_RS09075	COG0564	pseudouridine synthase activity
KZH43_RS09085	COG0577	efflux transmembrane transporter activity
KZH43_RS09095	COG0157	Belongs to the NadC ModD family
KZH43_RS09105	COG1129	ABC transporter
KZH43_RS09110	COG2188	Transcriptional regulator
KZH43_RS09115	COG2723	6-phospho-beta-galactosidase activity
KZH43_RS09130	COG1447	Phosphotransferase system cellobiose-specific component IIA
KZH43_RS09135	COG1012	belongs to the aldehyde dehydrogenase family
KZH43_RS09135	COG1454	alcohol dehydrogenase
KZH43_RS09145	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KZH43_RS09155	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KZH43_RS09175	COG3623	hexulose-6-phosphate isomerase
KZH43_RS09185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KZH43_RS09195	COG3037	sugar-specific permease SgaT UlaA
KZH43_RS09205	COG1847	R3H domain protein
KZH43_RS09210	COG0706	membrane insertase activity
KZH43_RS09220	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KZH43_RS09255	COG4537	Required for transformation and DNA binding
KZH43_RS09260	COG1459	type II secretion system
KZH43_RS09265	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KZH43_RS09275	COG1063	alcohol dehydrogenase
KZH43_RS09320	COG0131	Imidazoleglycerol-phosphate dehydratase
KZH43_RS09320	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KZH43_RS09325	COG0534	Mate efflux family protein
KZH43_RS09425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KZH43_RS09440	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KZH43_RS09445	COG1132	(ABC) transporter
KZH43_RS09455	COG1132	(ABC) transporter
KZH43_RS09465	COG1438	arginine binding
KZH43_RS09485	COG0745	RESPONSE REGULATOR receiver
KZH43_RS09490	COG5002	protein histidine kinase activity
KZH43_RS09495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KZH43_RS09510	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KZH43_RS09515	COG0704	Plays a role in the regulation of phosphate uptake
KZH43_RS09535	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KZH43_RS09545	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KZH43_RS09560	COG0697	spore germination
KZH43_RS09565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KZH43_RS09565	COG4499	WXG100 protein secretion system (Wss), protein YukC
KZH43_RS09575	COG2217	Heavy metal translocating P-type atpase
KZH43_RS09585	COG2226	methyltransferase
KZH43_RS09595	COG0058	SHG alpha-glucan phosphorylase activity
KZH43_RS09600	COG1640	4-alpha-glucanotransferase
KZH43_RS09605	COG2182	Extracellular solute-binding protein
KZH43_RS09610	COG1175	transmembrane transport
KZH43_RS09615	COG3833	ABC-type maltose transport systems, permease component
KZH43_RS09620	COG5521	maltodextrose utilization protein MalA
KZH43_RS09625	COG1609	Transcriptional regulator
KZH43_RS09635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KZH43_RS09670	COG1476	TRANSCRIPTIONal
KZH43_RS09700	COG2151	metal-sulfur cluster biosynthetic enzyme
KZH43_RS09710	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KZH43_RS09715	COG3959	Transketolase, thiamine diphosphate binding domain
KZH43_RS09730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KZH43_RS09750	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KZH43_RS09785	COG0383	alpha-mannosidase activity
KZH43_RS09795	COG3537	Alpha-1,2-mannosidase
KZH43_RS09815	COG0549	Belongs to the carbamate kinase family
KZH43_RS09820	COG1288	antiporter activity
KZH43_RS09825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KZH43_RS09850	COG1454	alcohol dehydrogenase
KZH43_RS09855	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
KZH43_RS09870	COG3716	PTS system mannose fructose sorbose family IID component
KZH43_RS09880	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KZH43_RS09900	COG1070	Carbohydrate kinase
KZH43_RS09910	COG3443	Belongs to the bacterial solute-binding protein 9 family
KZH43_RS09910	COG0803	Belongs to the bacterial solute-binding protein 9 family
KZH43_RS09915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KZH43_RS09920	COG1121	(ABC) transporter
KZH43_RS09925	COG1846	Transcriptional regulator
KZH43_RS09930	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KZH43_RS09940	COG1696	Membrane protein involved in D-alanine export
KZH43_RS09955	COG2211	Major facilitator Superfamily
KZH43_RS09975	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KZH43_RS09980	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KZH43_RS10000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KZH43_RS10010	COG1755	Isoprenylcysteine carboxyl methyltransferase
KZH43_RS10015	COG5002	protein histidine kinase activity
KZH43_RS10020	COG0745	RESPONSE REGULATOR receiver
KZH43_RS10025	COG0542	response to heat
KZH43_RS10030	COG4463	regulation of RNA biosynthetic process
KZH43_RS10035	COG1116	anion transmembrane transporter activity
KZH43_RS10040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KZH43_RS10045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KZH43_RS10065	COG0305	Participates in initiation and elongation during chromosome replication
KZH43_RS10085	COG1040	competence protein
KZH43_RS10090	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
KZH43_RS10095	COG1739	Uncharacterized protein family UPF0029
KZH43_RS10125	COG0052	Belongs to the universal ribosomal protein uS2 family
KZH43_RS10130	COG3942	CHAP domain
KZH43_RS10140	COG1792	Involved in formation and maintenance of cell shape
KZH43_RS10145	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KZH43_RS10150	COG1122	ATPase activity
KZH43_RS10155	COG1122	ATPase activity
KZH43_RS10160	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KZH43_RS10170	COG0612	Peptidase, M16
KZH43_RS10175	COG0612	Peptidase, M16
KZH43_RS10180	COG2501	S4 domain
KZH43_RS10190	COG0516	GMP reductase activity
KZH43_RS10190	COG0517	IMP dehydrogenase activity
KZH43_RS10195	COG0180	Tryptophanyl-tRNA synthetase
KZH43_RS10200	COG0488	(ABC) transporter
KZH43_RS10210	COG1511	domain protein
KZH43_RS10225	COG1511	domain protein
KZH43_RS10270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KZH43_RS10275	COG1475	DNA binding
KZH43_RS10530	COG1196	nuclear chromosome segregation
KZH43_RS10550	COG0560	Phosphoserine phosphatase
KZH43_RS10630	COG1132	(ABC) transporter
KZH43_RS10695	COG1132	(ABC) transporter