locus-tag	class	description
SPN032672_RS00005	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPN032672_RS00020	COG1942	4-Oxalocrotonate Tautomerase
SPN032672_RS00025	COG1435	thymidine kinase activity
SPN032672_RS00035	COG2890	protein-(glutamine-N5) methyltransferase activity
SPN032672_RS00060	COG0741	lytic transglycosylase activity
SPN032672_RS00070	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPN032672_RS00095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPN032672_RS00100	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPN032672_RS00150	COG1597	lipid kinase activity
SPN032672_RS00155	COG0366	Alpha amylase catalytic
SPN032672_RS00195	COG1131	(ABC) transporter
SPN032672_RS00220	COG0772	Belongs to the SEDS family
SPN032672_RS00225	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SPN032672_RS00240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPN032672_RS00245	COG0358	DNA primase activity
SPN032672_RS00250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPN032672_RS00255	COG2151	metal-sulfur cluster biosynthetic enzyme
SPN032672_RS00260	COG0438	transferase activity, transferring glycosyl groups
SPN032672_RS00265	COG0438	transferase activity, transferring glycosyl groups
SPN032672_RS00290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPN032672_RS00300	COG4109	DRTGG domain
SPN032672_RS00305	COG0024	Methionine aminopeptidase
SPN032672_RS00320	COG0210	DNA helicase
SPN032672_RS00330	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPN032672_RS00350	COG1104	cysteine desulfurase activity
SPN032672_RS00355	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPN032672_RS00365	COG2357	RelA SpoT domain protein
SPN032672_RS00375	COG0564	pseudouridine synthase activity
SPN032672_RS00380	COG0280	phosphate acetyltransferase
SPN032672_RS00425	COG0196	riboflavin kinase activity
SPN032672_RS00430	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPN032672_RS00435	COG1307	EDD domain protein, DegV family
SPN032672_RS00445	COG0488	(ABC) transporter
SPN032672_RS00475	COG1523	belongs to the glycosyl hydrolase 13 family
SPN032672_RS00490	COG1012	belongs to the aldehyde dehydrogenase family
SPN032672_RS00495	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SPN032672_RS00505	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SPN032672_RS00515	COG0560	Phosphoserine phosphatase
SPN032672_RS00520	COG0560	Phosphoserine phosphatase
SPN032672_RS00540	COG4974	Belongs to the 'phage' integrase family
SPN032672_RS00605	COG0582	viral genome integration into host DNA
SPN032672_RS00640	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
SPN032672_RS00640	COG3583	domain protein
SPN032672_RS00645	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPN032672_RS00665	COG0095	Lipoate-protein ligase
SPN032672_RS00670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPN032672_RS00675	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPN032672_RS00680	COG0022	dehydrogenase e1 component
SPN032672_RS00685	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPN032672_RS00690	COG0534	Mate efflux family protein
SPN032672_RS00700	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPN032672_RS00705	COG1051	belongs to the nudix hydrolase family
SPN032672_RS00720	COG1011	Hydrolase
SPN032672_RS00745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPN032672_RS00750	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPN032672_RS00755	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPN032672_RS00760	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPN032672_RS00770	COG2723	6-phospho-beta-galactosidase activity
SPN032672_RS00785	COG3711	transcriptional antiterminator
SPN032672_RS00790	COG3684	Belongs to the aldolase LacD family
SPN032672_RS00845	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SPN032672_RS00850	COG0497	DNA recombination
SPN032672_RS00855	COG1438	arginine binding
SPN032672_RS00860	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPN032672_RS00895	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SPN032672_RS00915	COG3764	Sortase (surface protein transpeptidase)
SPN032672_RS00920	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPN032672_RS00930	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SPN032672_RS00945	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPN032672_RS00950	COG5002	protein histidine kinase activity
SPN032672_RS00955	COG0745	RESPONSE REGULATOR receiver
SPN032672_RS00960	COG1194	a g-specific adenine glycosylase
SPN032672_RS00975	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPN032672_RS00980	COG4684	Psort location CytoplasmicMembrane, score
SPN032672_RS00990	COG1827	regulation of RNA biosynthetic process
SPN032672_RS00995	COG2816	NAD+ diphosphatase activity
SPN032672_RS01020	COG0765	amino acid transport
SPN032672_RS01025	COG1126	abc transporter atp-binding protein
SPN032672_RS01030	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPN032672_RS01035	COG0552	protein localization to endoplasmic reticulum
SPN032672_RS01040	COG0561	phosphatase activity
SPN032672_RS01045	COG0561	phosphatase activity
SPN032672_RS01050	COG1196	nuclear chromosome segregation
SPN032672_RS01075	COG1401	restriction endodeoxyribonuclease activity
SPN032672_RS01090	COG0066	3-isopropylmalate dehydratase activity
SPN032672_RS01100	COG0473	3-isopropylmalate dehydrogenase activity
SPN032672_RS01105	COG0473	3-isopropylmalate dehydrogenase activity
SPN032672_RS01120	COG3142	Participates in the control of copper homeostasis
SPN032672_RS01125	COG2832	Protein of unknown function (DUF454)
SPN032672_RS01130	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPN032672_RS01140	COG0758	DNA mediated transformation
SPN032672_RS01145	COG4750	Nucleotidyl transferase
SPN032672_RS01160	COG1063	alcohol dehydrogenase
SPN032672_RS01175	COG3475	LICD family
SPN032672_RS01180	COG3475	LICD family
SPN032672_RS01190	COG0505	Belongs to the CarA family
SPN032672_RS01205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPN032672_RS01220	COG0488	(ABC) transporter
SPN032672_RS01225	COG0501	Belongs to the peptidase M48B family
SPN032672_RS01230	COG1704	LemA family
SPN032672_RS01245	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPN032672_RS01260	COG1078	dGTPase activity
SPN032672_RS01285	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPN032672_RS01290	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPN032672_RS01295	COG1605	Chorismate mutase
SPN032672_RS01295	COG0077	Prephenate dehydratase
SPN032672_RS01300	COG0716	FMN binding
SPN032672_RS01305	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPN032672_RS01330	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPN032672_RS01375	COG0295	cytidine deaminase activity
SPN032672_RS01405	COG0395	ABC-type sugar transport system, permease component
SPN032672_RS01410	COG4209	transmembrane transport
SPN032672_RS01415	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SPN032672_RS01430	COG2801	Transposase and inactivated derivatives
SPN032672_RS01445	COG0577	efflux transmembrane transporter activity
SPN032672_RS01445	COG1136	(ABC) transporter
SPN032672_RS01455	COG1770	oligopeptidase
SPN032672_RS01460	COG0515	serine threonine protein kinase
SPN032672_RS01495	COG0402	S-adenosylhomocysteine deaminase activity
SPN032672_RS01505	COG1132	(ABC) transporter
SPN032672_RS01510	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPN032672_RS01510	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPN032672_RS01545	COG1215	transferase activity, transferring glycosyl groups
SPN032672_RS01555	COG3475	LICD family
SPN032672_RS01570	COG0077	Prephenate dehydratase
SPN032672_RS01575	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SPN032672_RS01580	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SPN032672_RS01590	COG0287	Prephenate dehydrogenase
SPN032672_RS01615	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPN032672_RS01625	COG1131	(ABC) transporter
SPN032672_RS01665	COG3842	ATPase activity
SPN032672_RS01680	COG3527	Alpha-acetolactate decarboxylase
SPN032672_RS01685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPN032672_RS01690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN032672_RS01695	COG0704	Plays a role in the regulation of phosphate uptake
SPN032672_RS01700	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPN032672_RS01705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPN032672_RS01710	COG0581	inorganic phosphate transmembrane transporter activity
SPN032672_RS01715	COG0573	inorganic phosphate transmembrane transporter activity
SPN032672_RS01720	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPN032672_RS01725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPN032672_RS01725	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPN032672_RS01730	COG0483	inositol monophosphate 1-phosphatase activity
SPN032672_RS01740	COG1393	Belongs to the ArsC family
SPN032672_RS01750	COG0647	UMP catabolic process
SPN032672_RS01760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPN032672_RS01820	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPN032672_RS01840	COG1131	(ABC) transporter
SPN032672_RS01845	COG0826	peptidase U32
SPN032672_RS01855	COG0826	peptidase U32
SPN032672_RS01880	COG1132	(ABC) transporter
SPN032672_RS01885	COG1132	(ABC) transporter
SPN032672_RS01900	COG1129	ABC transporter
SPN032672_RS01945	COG2188	Transcriptional regulator
SPN032672_RS01950	COG0697	spore germination
SPN032672_RS01955	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPN032672_RS01970	COG0561	phosphatase activity
SPN032672_RS02000	COG0492	ferredoxin-NADP+ reductase activity
SPN032672_RS02010	COG1126	abc transporter atp-binding protein
SPN032672_RS02020	COG1393	Belongs to the ArsC family
SPN032672_RS02040	COG1272	protein, Hemolysin III
SPN032672_RS02070	COG0431	NADPH-dependent FMN reductase
SPN032672_RS02070	COG1053	succinate dehydrogenase
SPN032672_RS02070	COG3976	FMN-binding domain protein
SPN032672_RS02105	COG0656	L-ascorbic acid biosynthetic process
SPN032672_RS02110	COG0726	polysaccharide deacetylase
SPN032672_RS02140	COG3335	DDE superfamily endonuclease
SPN032672_RS02155	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPN032672_RS02205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPN032672_RS02215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN032672_RS02220	COG1126	abc transporter atp-binding protein
SPN032672_RS02235	COG0628	permease
SPN032672_RS02240	COG2706	6-phosphogluconolactonase activity
SPN032672_RS02300	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPN032672_RS02325	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPN032672_RS02330	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SPN032672_RS02335	COG0626	cystathionine gamma-synthase activity
SPN032672_RS02345	COG1132	(ABC) transporter
SPN032672_RS02350	COG1132	(ABC) transporter
SPN032672_RS02355	COG4166	transmembrane transport
SPN032672_RS02360	COG2244	polysaccharide biosynthetic process
SPN032672_RS02365	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPN032672_RS02395	COG2827	Endonuclease containing a URI domain
SPN032672_RS02400	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPN032672_RS02405	COG1098	S1 RNA binding domain
SPN032672_RS02415	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPN032672_RS02420	COG0629	single-stranded DNA binding
SPN032672_RS02430	COG0017	Asparaginyl-tRNA synthetase
SPN032672_RS02440	COG0436	Aminotransferase
SPN032672_RS02465	COG3711	transcriptional antiterminator
SPN032672_RS02485	COG0242	peptide deformylase activity
SPN032672_RS02490	COG0625	glutathione transferase activity
SPN032672_RS02500	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPN032672_RS02505	COG0488	(ABC) transporter
SPN032672_RS02510	COG0617	tRNA 3'-terminal CCA addition
SPN032672_RS02520	COG1307	EDD domain protein, DegV family
SPN032672_RS02540	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPN032672_RS02560	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SPN032672_RS02570	COG0251	oxidation-reduction process
SPN032672_RS02590	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPN032672_RS02600	COG4193	domain, Protein
SPN032672_RS02600	COG5263	repeat protein
SPN032672_RS02610	COG3935	DnaD domain protein
SPN032672_RS02625	COG2226	methyltransferase
SPN032672_RS02635	COG3842	ATPase activity
SPN032672_RS02655	COG0513	Belongs to the DEAD box helicase family
SPN032672_RS02675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPN032672_RS02680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPN032672_RS02685	COG3442	glutamine amidotransferase
SPN032672_RS02690	COG0006	proline dipeptidase activity
SPN032672_RS02695	COG2801	Transposase and inactivated derivatives
SPN032672_RS02710	COG4720	Psort location CytoplasmicMembrane, score
SPN032672_RS02715	COG0351	phosphomethylpyrimidine kinase
SPN032672_RS02740	COG2824	Alkylphosphonate utilization operon protein PhnA
SPN032672_RS02765	COG0463	Glycosyl transferase, family 2
SPN032672_RS02770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPN032672_RS02780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPN032672_RS02785	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SPN032672_RS02790	COG2384	SAM-dependent methyltransferase
SPN032672_RS02795	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SPN032672_RS02800	COG0204	Acyl-transferase
SPN032672_RS02815	COG2910	NAD(P)H-binding
SPN032672_RS02840	COG5002	protein histidine kinase activity
SPN032672_RS02845	COG0745	RESPONSE REGULATOR receiver
SPN032672_RS02860	COG1959	2 iron, 2 sulfur cluster binding
SPN032672_RS02940	COG3590	peptidase
SPN032672_RS02960	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPN032672_RS02965	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SPN032672_RS02980	COG0577	efflux transmembrane transporter activity
SPN032672_RS02980	COG1136	(ABC) transporter
SPN032672_RS03025	COG3599	regulation of cell shape
SPN032672_RS03045	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPN032672_RS03065	COG1051	belongs to the nudix hydrolase family
SPN032672_RS03070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPN032672_RS03085	COG0768	penicillin binding
SPN032672_RS03100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPN032672_RS03120	COG2731	YhcH YjgK YiaL family protein
SPN032672_RS03125	COG0395	ABC-type sugar transport system, permease component
SPN032672_RS03130	COG1175	transmembrane transport
SPN032672_RS03140	COG2190	(PTS) system
SPN032672_RS03140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN032672_RS03140	COG1263	PTS System
SPN032672_RS03150	COG0673	inositol 2-dehydrogenase activity
SPN032672_RS03155	COG4409	exo-alpha-(2->6)-sialidase activity
SPN032672_RS03165	COG1175	transmembrane transport
SPN032672_RS03170	COG1653	transport
SPN032672_RS03190	COG3458	cephalosporin-C deacetylase activity
SPN032672_RS03195	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPN032672_RS03210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPN032672_RS03215	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPN032672_RS03220	COG0653	protein targeting
SPN032672_RS03230	COG1131	(ABC) transporter
SPN032672_RS03260	COG0778	Nitroreductase
SPN032672_RS03265	COG1484	DNA-dependent DNA replication
SPN032672_RS03280	COG1725	Transcriptional regulator
SPN032672_RS03285	COG1131	(ABC) transporter
SPN032672_RS03295	COG1668	transmembrane transport
SPN032672_RS03300	COG4152	abc transporter atp-binding protein
SPN032672_RS03320	COG1940	carbohydrate kinase activity
SPN032672_RS03325	COG2190	(PTS) system
SPN032672_RS03325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN032672_RS03325	COG1263	PTS System
SPN032672_RS03335	COG1621	beta-fructofuranosidase activity
SPN032672_RS03340	COG1609	Transcriptional regulator
SPN032672_RS03350	COG3425	synthase
SPN032672_RS03375	COG2815	serine threonine protein kinase
SPN032672_RS03375	COG0515	serine threonine protein kinase
SPN032672_RS03380	COG0631	protein serine/threonine phosphatase activity
SPN032672_RS03385	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPN032672_RS03385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPN032672_RS03395	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPN032672_RS03405	COG0194	GDP metabolic process
SPN032672_RS03430	COG2226	methyltransferase
SPN032672_RS03435	COG0799	negative regulation of ribosome biogenesis
SPN032672_RS03445	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPN032672_RS03450	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SPN032672_RS03455	COG1534	Rna-binding protein
SPN032672_RS03460	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPN032672_RS03475	COG0668	transmembrane transport
SPN032672_RS03505	COG0438	transferase activity, transferring glycosyl groups
SPN032672_RS03510	COG0438	transferase activity, transferring glycosyl groups
SPN032672_RS03515	COG0653	protein targeting
SPN032672_RS03535	COG0201	protein transport
SPN032672_RS03540	COG1215	transferase activity, transferring glycosyl groups
SPN032672_RS03545	COG1215	transferase activity, transferring glycosyl groups
SPN032672_RS03550	COG1442	glycosyl transferase family 8
SPN032672_RS03555	COG1442	glycosyl transferase family 8
SPN032672_RS03560	COG1442	glycosyl transferase family 8
SPN032672_RS03565	COG0438	transferase activity, transferring glycosyl groups
SPN032672_RS03570	COG1216	Glycosyl transferase, family 2
SPN032672_RS03570	COG1442	glycosyl transferase family 8
SPN032672_RS03575	COG1442	glycosyl transferase family 8
SPN032672_RS03580	COG1216	Glycosyl transferase, family 2
SPN032672_RS03580	COG1442	glycosyl transferase family 8
SPN032672_RS03585	COG1216	Glycosyl transferase, family 2
SPN032672_RS03585	COG1442	glycosyl transferase family 8
SPN032672_RS03610	COG3118	belongs to the thioredoxin family
SPN032672_RS03615	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SPN032672_RS03620	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPN032672_RS03635	COG1164	Oligoendopeptidase f
SPN032672_RS03640	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPN032672_RS03645	COG2264	protein methyltransferase activity
SPN032672_RS03650	COG1051	belongs to the nudix hydrolase family
SPN032672_RS03690	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPN032672_RS03700	COG1621	beta-fructofuranosidase activity
SPN032672_RS03705	COG0395	ABC-type sugar transport system, permease component
SPN032672_RS03720	COG1175	transmembrane transport
SPN032672_RS03730	COG1609	Transcriptional regulator
SPN032672_RS03735	COG3711	transcriptional antiterminator
SPN032672_RS03760	COG3237	CsbD-like
SPN032672_RS03780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPN032672_RS03790	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN032672_RS03795	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPN032672_RS03800	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN032672_RS03815	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN032672_RS03820	COG1846	Transcriptional regulator
SPN032672_RS03820	COG1940	carbohydrate kinase activity
SPN032672_RS03830	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SPN032672_RS03870	COG0512	Glutamine amidotransferase of anthranilate synthase
SPN032672_RS03875	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPN032672_RS03900	COG1285	pathogenesis
SPN032672_RS03905	COG1178	ABC-type Fe3 transport system permease component
SPN032672_RS03935	COG5434	Belongs to the glycosyl hydrolase 28 family
SPN032672_RS03950	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SPN032672_RS03955	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPN032672_RS03960	COG1132	(ABC) transporter
SPN032672_RS03965	COG1132	(ABC) transporter
SPN032672_RS03990	COG0708	Exodeoxyribonuclease III
SPN032672_RS04010	COG2233	PERMEase
SPN032672_RS04040	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPN032672_RS04045	COG1609	Transcriptional regulator
SPN032672_RS04050	COG1063	alcohol dehydrogenase
SPN032672_RS04055	COG0789	Transcriptional regulator
SPN032672_RS04060	COG1230	cation diffusion facilitator family transporter
SPN032672_RS04070	COG3201	nicotinamide mononucleotide transporter
SPN032672_RS04075	COG1174	glycine betaine transport
SPN032672_RS04100	COG1363	Peptidase, m42
SPN032672_RS04115	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPN032672_RS04120	COG4605	iron ion homeostasis
SPN032672_RS04125	COG4604	ABC transporter, ATP-binding protein
SPN032672_RS04130	COG4607	ABC-type enterochelin transport system periplasmic component
SPN032672_RS04140	COG1187	pseudouridine synthase activity
SPN032672_RS04160	COG0517	IMP dehydrogenase activity
SPN032672_RS04170	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SPN032672_RS04185	COG0366	Alpha amylase catalytic
SPN032672_RS04190	COG1263	PTS System
SPN032672_RS04190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN032672_RS04195	COG2188	Transcriptional regulator
SPN032672_RS04200	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPN032672_RS04220	COG4608	Belongs to the ABC transporter superfamily
SPN032672_RS04225	COG0444	Belongs to the ABC transporter superfamily
SPN032672_RS04230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPN032672_RS04235	COG0601	transmembrane transport
SPN032672_RS04240	COG4166	transmembrane transport
SPN032672_RS04250	COG0366	Alpha amylase catalytic
SPN032672_RS04260	COG0395	ABC-type sugar transport system, permease component
SPN032672_RS04265	COG1175	transmembrane transport
SPN032672_RS04270	COG1653	transport
SPN032672_RS04275	COG3345	alpha-galactosidase
SPN032672_RS04280	COG2207	Transcriptional regulator
SPN032672_RS04285	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPN032672_RS04285	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPN032672_RS04410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPN032672_RS04415	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SPN032672_RS04440	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPN032672_RS04445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPN032672_RS04455	COG0012	GTP binding
SPN032672_RS04465	COG0592	DNA-directed DNA polymerase activity
SPN032672_RS04475	COG1475	DNA binding
SPN032672_RS04480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPN032672_RS04525	COG1511	domain protein
SPN032672_RS04545	COG2801	Transposase and inactivated derivatives
SPN032672_RS04555	COG0488	(ABC) transporter
SPN032672_RS04560	COG0180	Tryptophanyl-tRNA synthetase
SPN032672_RS04565	COG0517	IMP dehydrogenase activity
SPN032672_RS04565	COG0516	GMP reductase activity
SPN032672_RS04575	COG2501	S4 domain
SPN032672_RS04580	COG0612	Peptidase, M16
SPN032672_RS04585	COG0612	Peptidase, M16
SPN032672_RS04595	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPN032672_RS04605	COG1122	ATPase activity
SPN032672_RS04610	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPN032672_RS04615	COG1792	Involved in formation and maintenance of cell shape
SPN032672_RS04625	COG3942	CHAP domain
SPN032672_RS04645	COG3335	DDE superfamily endonuclease
SPN032672_RS04660	COG1739	Uncharacterized protein family UPF0029
SPN032672_RS04665	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPN032672_RS04670	COG1040	competence protein
SPN032672_RS04690	COG0305	Participates in initiation and elongation during chromosome replication
SPN032672_RS04710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SPN032672_RS04715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SPN032672_RS04720	COG1116	anion transmembrane transporter activity
SPN032672_RS04725	COG4463	regulation of RNA biosynthetic process
SPN032672_RS04730	COG0542	response to heat
SPN032672_RS04735	COG0745	RESPONSE REGULATOR receiver
SPN032672_RS04740	COG5002	protein histidine kinase activity
SPN032672_RS04745	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPN032672_RS04750	COG0366	Alpha amylase catalytic
SPN032672_RS04760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPN032672_RS04780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SPN032672_RS04785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPN032672_RS04805	COG3344	reverse transcriptase
SPN032672_RS04825	COG1696	Membrane protein involved in D-alanine export
SPN032672_RS04835	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPN032672_RS04840	COG1846	Transcriptional regulator
SPN032672_RS04845	COG1121	(ABC) transporter
SPN032672_RS04850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPN032672_RS04855	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPN032672_RS04855	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPN032672_RS04865	COG1070	Carbohydrate kinase
SPN032672_RS04885	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN032672_RS04895	COG3716	PTS system mannose fructose sorbose family IID component
SPN032672_RS04930	COG1454	alcohol dehydrogenase
SPN032672_RS04940	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPN032672_RS04940	COG3583	domain protein
SPN032672_RS04940	COG3064	Membrane
SPN032672_RS04955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPN032672_RS04960	COG1288	antiporter activity
SPN032672_RS04965	COG0549	Belongs to the carbamate kinase family
SPN032672_RS04985	COG3537	Alpha-1,2-mannosidase
SPN032672_RS04995	COG0383	alpha-mannosidase activity
SPN032672_RS05035	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPN032672_RS05055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPN032672_RS05070	COG3959	Transketolase, thiamine diphosphate binding domain
SPN032672_RS05075	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPN032672_RS05085	COG2151	metal-sulfur cluster biosynthetic enzyme
SPN032672_RS05100	COG0124	histidyl-tRNA synthetase
SPN032672_RS05115	COG1476	TRANSCRIPTIONal
SPN032672_RS05150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPN032672_RS05160	COG1609	Transcriptional regulator
SPN032672_RS05165	COG5521	maltodextrose utilization protein MalA
SPN032672_RS05170	COG3833	ABC-type maltose transport systems, permease component
SPN032672_RS05175	COG1175	transmembrane transport
SPN032672_RS05180	COG2182	Extracellular solute-binding protein
SPN032672_RS05185	COG1640	4-alpha-glucanotransferase
SPN032672_RS05190	COG0058	SHG alpha-glucan phosphorylase activity
SPN032672_RS05210	COG2226	methyltransferase
SPN032672_RS05220	COG2217	Heavy metal translocating P-type atpase
SPN032672_RS05230	COG4499	WXG100 protein secretion system (Wss), protein YukC
SPN032672_RS05230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPN032672_RS05235	COG0697	spore germination
SPN032672_RS05250	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPN032672_RS05260	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPN032672_RS05280	COG0704	Plays a role in the regulation of phosphate uptake
SPN032672_RS05285	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPN032672_RS05295	COG0573	inorganic phosphate transmembrane transporter activity
SPN032672_RS05300	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPN032672_RS05305	COG5002	protein histidine kinase activity
SPN032672_RS05310	COG0745	RESPONSE REGULATOR receiver
SPN032672_RS05330	COG1438	arginine binding
SPN032672_RS05340	COG1132	(ABC) transporter
SPN032672_RS05350	COG1132	(ABC) transporter
SPN032672_RS05355	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPN032672_RS05470	COG0534	Mate efflux family protein
SPN032672_RS05475	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SPN032672_RS05475	COG0131	Imidazoleglycerol-phosphate dehydratase
SPN032672_RS05490	COG3759	membrane
SPN032672_RS05495	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SPN032672_RS05520	COG1063	alcohol dehydrogenase
SPN032672_RS05530	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPN032672_RS05535	COG1459	type II secretion system
SPN032672_RS05540	COG4537	Required for transformation and DNA binding
SPN032672_RS05595	COG0706	membrane insertase activity
SPN032672_RS05600	COG1847	R3H domain protein
SPN032672_RS05610	COG3037	sugar-specific permease SgaT UlaA
SPN032672_RS05620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPN032672_RS05630	COG3623	hexulose-6-phosphate isomerase
SPN032672_RS05650	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SPN032672_RS05660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPN032672_RS05670	COG1012	belongs to the aldehyde dehydrogenase family
SPN032672_RS05670	COG1454	alcohol dehydrogenase
SPN032672_RS05675	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPN032672_RS05685	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN032672_RS05690	COG2723	6-phospho-beta-galactosidase activity
SPN032672_RS05695	COG2188	Transcriptional regulator
SPN032672_RS05700	COG4133	protoheme IX ABC transporter activity
SPN032672_RS05710	COG0157	Belongs to the NadC ModD family
SPN032672_RS05725	COG0577	efflux transmembrane transporter activity
SPN032672_RS05735	COG0564	pseudouridine synthase activity
SPN032672_RS05740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPN032672_RS05745	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPN032672_RS05845	COG1131	(ABC) transporter
SPN032672_RS05850	COG0842	Transport permease protein
SPN032672_RS05855	COG4585	Histidine kinase
SPN032672_RS05860	COG2197	response regulator
SPN032672_RS05865	COG1609	Transcriptional regulator
SPN032672_RS05875	COG0252	asparaginase activity
SPN032672_RS05880	COG0561	phosphatase activity
SPN032672_RS05885	COG0589	response to stress
SPN032672_RS05895	COG0436	Aminotransferase
SPN032672_RS05915	COG0084	hydrolase, TatD family'
SPN032672_RS05920	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SPN032672_RS05960	COG1162	GTPase activity
SPN032672_RS05970	COG1564	THIamine pyrophosphokinase
SPN032672_RS05985	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPN032672_RS05995	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPN032672_RS06005	COG1254	Belongs to the acylphosphatase family
SPN032672_RS06010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPN032672_RS06030	COG0742	ribosomal rna small subunit methyltransferase
SPN032672_RS06035	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SPN032672_RS06040	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPN032672_RS06050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPN032672_RS06065	COG1253	flavin adenine dinucleotide binding
SPN032672_RS06100	COG1136	(ABC) transporter
SPN032672_RS06130	COG0802	atpase or kinase
SPN032672_RS06140	COG1316	TRANSCRIPTIONal
SPN032672_RS06170	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPN032672_RS06170	COG5263	repeat protein
SPN032672_RS06260	COG1132	(ABC) transporter
SPN032672_RS06295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPN032672_RS06300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPN032672_RS06305	COG4221	oxidoreductase activity
SPN032672_RS06340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPN032672_RS06385	COG3335	DDE superfamily endonuclease
SPN032672_RS06420	COG0756	dUTP diphosphatase activity
SPN032672_RS06430	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SPN032672_RS06445	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPN032672_RS06465	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPN032672_RS06465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPN032672_RS06470	COG1832	CoA-binding protein
SPN032672_RS06480	COG2855	membrane
SPN032672_RS06485	COG0436	Aminotransferase
SPN032672_RS06500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPN032672_RS06520	COG2274	protein secretion by the type I secretion system
SPN032672_RS06525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPN032672_RS06535	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPN032672_RS06540	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SPN032672_RS06550	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPN032672_RS06565	COG0151	Belongs to the GarS family
SPN032672_RS06570	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPN032672_RS06585	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPN032672_RS06590	COG3583	domain protein
SPN032672_RS06590	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPN032672_RS06590	COG3064	Membrane
SPN032672_RS06605	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN032672_RS06610	COG3715	PTS system
SPN032672_RS06615	COG3716	PTS system mannose fructose sorbose family IID component
SPN032672_RS06625	COG2222	sugar isomerase
SPN032672_RS06635	COG2514	catechol 2,3-dioxygenase activity
SPN032672_RS06640	COG1937	Protein conserved in bacteria
SPN032672_RS06665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPN032672_RS06670	COG0569	domain protein
SPN032672_RS06680	COG1215	transferase activity, transferring glycosyl groups
SPN032672_RS06700	COG5002	protein histidine kinase activity
SPN032672_RS06720	COG4209	transmembrane transport
SPN032672_RS06725	COG0395	ABC-type sugar transport system, permease component
SPN032672_RS06730	COG1653	transport
SPN032672_RS06760	COG1695	Transcriptional regulator
SPN032672_RS06785	COG0546	phosphoglycolate phosphatase activity
SPN032672_RS06790	COG1760	l-serine dehydratase
SPN032672_RS06795	COG1760	l-serine dehydratase
SPN032672_RS06900	COG0445	tRNA wobble uridine modification
SPN032672_RS06935	COG1214	PFAM Peptidase M22, glycoprotease
SPN032672_RS06970	COG0438	transferase activity, transferring glycosyl groups
SPN032672_RS07015	COG1396	sequence-specific DNA binding
SPN032672_RS07055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN032672_RS07065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN032672_RS07070	COG1464	Belongs to the NlpA lipoprotein family
SPN032672_RS07075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPN032672_RS07080	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPN032672_RS07100	COG2972	Histidine kinase
SPN032672_RS07105	COG2207	Transcriptional regulator
SPN032672_RS07105	COG4753	response regulator
SPN032672_RS07115	COG1780	Probably involved in ribonucleotide reductase function
SPN032672_RS07150	COG0019	diaminopimelate decarboxylase activity
SPN032672_RS07180	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPN032672_RS07180	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPN032672_RS07200	COG2818	Glycosylase
SPN032672_RS07225	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPN032672_RS07230	COG0006	proline dipeptidase activity
SPN032672_RS07240	COG1393	Belongs to the ArsC family
SPN032672_RS07265	COG0285	dihydrofolate synthase activity
SPN032672_RS07275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPN032672_RS07340	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPN032672_RS07365	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SPN032672_RS07405	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SPN032672_RS07420	COG0201	protein transport
SPN032672_RS07435	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SPN032672_RS07440	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SPN032672_RS07450	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SPN032672_RS07455	COG0202	RNA polymerase activity
SPN032672_RS07465	COG3830	Belongs to the UPF0237 family
SPN032672_RS07505	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPN032672_RS07510	COG1349	DNA-binding transcription factor activity
SPN032672_RS07520	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPN032672_RS07525	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN032672_RS07530	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN032672_RS07535	COG1882	Formate acetyltransferase
SPN032672_RS07580	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPN032672_RS07585	COG4589	Belongs to the CDS family
SPN032672_RS07590	COG0750	zinc metalloprotease
SPN032672_RS07600	COG2723	6-phospho-beta-galactosidase activity
SPN032672_RS07605	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPN032672_RS07615	COG1523	belongs to the glycosyl hydrolase 13 family
SPN032672_RS07635	COG2176	DNA-directed DNA polymerase activity
SPN032672_RS07655	COG2309	aminopeptidase activity
SPN032672_RS07660	COG2261	transglycosylase associated protein
SPN032672_RS07665	COG1187	pseudouridine synthase activity
SPN032672_RS07675	COG3579	cysteine-type endopeptidase activity
SPN032672_RS07680	COG3716	PTS system mannose fructose sorbose family IID component
SPN032672_RS07685	COG3715	PTS system
SPN032672_RS07695	COG1064	alcohol dehydrogenase
SPN032672_RS07700	COG0561	phosphatase activity
SPN032672_RS07705	COG2252	PERMEase
SPN032672_RS07715	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SPN032672_RS07720	COG0285	dihydrofolate synthase activity
SPN032672_RS07730	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPN032672_RS07730	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SPN032672_RS07745	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPN032672_RS07765	COG2723	6-phospho-beta-galactosidase activity
SPN032672_RS07780	COG3711	transcriptional antiterminator
SPN032672_RS07780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPN032672_RS07795	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN032672_RS07810	COG0386	Belongs to the glutathione peroxidase family
SPN032672_RS07815	COG5492	domain, Protein
SPN032672_RS07840	COG1028	Short-chain dehydrogenase reductase Sdr
SPN032672_RS07850	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SPN032672_RS07855	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN032672_RS07860	COG3715	PTS system
SPN032672_RS07865	COG3716	PTS system mannose fructose sorbose family IID component
SPN032672_RS07880	COG1609	Transcriptional regulator
SPN032672_RS07910	COG4839	cell division protein FtsL
SPN032672_RS07915	COG0768	penicillin binding
SPN032672_RS07990	COG3344	reverse transcriptase
SPN032672_RS08005	COG0366	Alpha amylase catalytic
SPN032672_RS08010	COG4166	transmembrane transport
SPN032672_RS08050	COG3944	biosynthesis protein
SPN032672_RS08110	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SPN032672_RS08120	COG1088	dTDP-glucose 4,6-dehydratase activity
SPN032672_RS08135	COG4372	Transposase
SPN032672_RS08140	COG4166	transmembrane transport
SPN032672_RS08145	COG0366	Alpha amylase catalytic
SPN032672_RS08150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPN032672_RS08175	COG0116	Belongs to the methyltransferase superfamily
SPN032672_RS08185	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SPN032672_RS08190	COG0745	RESPONSE REGULATOR receiver
SPN032672_RS08240	COG4585	Histidine kinase
SPN032672_RS08245	COG2197	response regulator
SPN032672_RS08275	COG0582	viral genome integration into host DNA
SPN032672_RS08285	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPN032672_RS08290	COG0681	Belongs to the peptidase S26 family
SPN032672_RS08315	COG1115	amino acid carrier protein
SPN032672_RS08340	COG0527	aspartate kinase activity
SPN032672_RS08345	COG1024	Enoyl-CoA hydratase
SPN032672_RS08350	COG1846	Transcriptional regulator
SPN032672_RS08360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPN032672_RS08370	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPN032672_RS08375	COG1028	Short-chain dehydrogenase reductase Sdr
SPN032672_RS08380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPN032672_RS08395	COG0439	Biotin carboxylase
SPN032672_RS08400	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPN032672_RS08435	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SPN032672_RS08460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SPN032672_RS08470	COG1461	Dihydroxyacetone kinase
SPN032672_RS08475	COG0028	Belongs to the TPP enzyme family
SPN032672_RS08480	COG0440	acetolactate synthase activity
SPN032672_RS08500	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SPN032672_RS08515	COG0765	amino acid transport
SPN032672_RS08540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPN032672_RS08545	COG1882	Formate acetyltransferase
SPN032672_RS08575	COG1846	Transcriptional regulator
SPN032672_RS08575	COG1940	carbohydrate kinase activity
SPN032672_RS08580	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN032672_RS08590	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPN032672_RS08595	COG2723	6-phospho-beta-galactosidase activity
SPN032672_RS08600	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN032672_RS08600	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN032672_RS08605	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPN032672_RS08610	COG0569	domain protein
SPN032672_RS08630	COG1122	ATPase activity
SPN032672_RS08645	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPN032672_RS08650	COG0671	phosphoesterase, PA-phosphatase related
SPN032672_RS08670	COG1132	(ABC) transporter
SPN032672_RS08685	COG1247	-acetyltransferase
SPN032672_RS08695	COG0504	CTP synthase activity
SPN032672_RS08700	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPN032672_RS08720	COG0789	Transcriptional regulator
SPN032672_RS08725	COG0174	glutamine synthetase
SPN032672_RS08735	COG0732	type I restriction modification DNA specificity domain
SPN032672_RS08740	COG0732	type I restriction modification DNA specificity domain
SPN032672_RS08780	COG0484	heat shock protein binding
SPN032672_RS08795	COG0537	adenosine 5'-monophosphoramidase activity
SPN032672_RS08800	COG1131	(ABC) transporter
SPN032672_RS08825	COG3290	protein histidine kinase activity
SPN032672_RS08835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPN032672_RS08840	COG2274	protein secretion by the type I secretion system
SPN032672_RS08845	COG2274	protein secretion by the type I secretion system
SPN032672_RS08940	COG1266	CAAX protease self-immunity
SPN032672_RS08960	COG0195	Participates in both transcription termination and antitermination
SPN032672_RS08965	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPN032672_RS09045	COG0519	Catalyzes the synthesis of GMP from XMP
SPN032672_RS09055	COG0525	valine-tRNA ligase activity
SPN032672_RS09070	COG2801	Transposase and inactivated derivatives
SPN032672_RS09075	COG2801	Transposase and inactivated derivatives
SPN032672_RS09095	COG3711	transcriptional antiterminator
SPN032672_RS09100	COG1263	PTS System
SPN032672_RS09100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN032672_RS09100	COG2190	(PTS) system
SPN032672_RS09115	COG0456	acetyltransferase
SPN032672_RS09120	COG0072	phenylalanine-tRNA ligase activity
SPN032672_RS09120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPN032672_RS09135	COG3620	sequence-specific DNA binding
SPN032672_RS09155	COG1045	serine acetyltransferase
SPN032672_RS09165	COG0215	cysteine-tRNA ligase activity
SPN032672_RS09170	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPN032672_RS09205	COG0577	efflux transmembrane transporter activity
SPN032672_RS09210	COG1136	(ABC) transporter
SPN032672_RS09215	COG0577	efflux transmembrane transporter activity
SPN032672_RS09220	COG0745	RESPONSE REGULATOR receiver
SPN032672_RS09225	COG5002	protein histidine kinase activity
SPN032672_RS09230	COG0191	fructose-bisphosphate aldolase activity
SPN032672_RS09235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SPN032672_RS09240	COG0765	amino acid transport
SPN032672_RS09245	COG0765	amino acid transport
SPN032672_RS09250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN032672_RS09260	COG1126	abc transporter atp-binding protein
SPN032672_RS09265	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPN032672_RS09265	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPN032672_RS09305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN032672_RS09320	COG1573	uracil-dna glycosylase
SPN032672_RS09330	COG1114	Component of the transport system for branched-chain amino acids
SPN032672_RS09335	COG1363	Peptidase, m42
SPN032672_RS09375	COG4555	ABC transporter
SPN032672_RS09410	COG1404	Belongs to the peptidase S8 family
SPN032672_RS09415	COG4372	Transposase
SPN032672_RS09430	COG3775	system Galactitol-specific IIC component
SPN032672_RS09440	COG3250	beta-galactosidase activity
SPN032672_RS09460	COG1242	4 iron, 4 sulfur cluster binding
SPN032672_RS09465	COG1242	4 iron, 4 sulfur cluster binding
SPN032672_RS09470	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPN032672_RS09490	COG0785	Cytochrome C biogenesis protein
SPN032672_RS09495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPN032672_RS09500	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPN032672_RS09500	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPN032672_RS09505	COG2207	Transcriptional regulator
SPN032672_RS09505	COG4753	response regulator
SPN032672_RS09510	COG2972	Histidine kinase
SPN032672_RS09520	COG3064	Membrane
SPN032672_RS09525	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPN032672_RS09540	COG1940	carbohydrate kinase activity
SPN032672_RS09560	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPN032672_RS09565	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPN032672_RS09575	COG0300	oxidoreductase activity
SPN032672_RS09590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPN032672_RS09600	COG1187	pseudouridine synthase activity
SPN032672_RS09605	COG1217	gtp-binding protein TYPA
SPN032672_RS09625	COG1136	(ABC) transporter
SPN032672_RS09640	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SPN032672_RS09670	COG2826	transposase and inactivated derivatives, IS30 family
SPN032672_RS09680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SPN032672_RS09705	COG1131	(ABC) transporter
SPN032672_RS09715	COG1126	abc transporter atp-binding protein
SPN032672_RS09720	COG1129	ABC transporter
SPN032672_RS09725	COG4215	(ABC) transporter
SPN032672_RS09730	COG0765	amino acid transport
SPN032672_RS09735	COG1304	FMN binding
SPN032672_RS09740	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SPN032672_RS09745	COG1304	FMN binding
SPN032672_RS09755	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SPN032672_RS09760	COG0352	thiamine-phosphate diphosphorylase activity
SPN032672_RS09770	COG4172	Belongs to the ABC transporter superfamily
SPN032672_RS09780	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SPN032672_RS09795	COG0352	thiamine-phosphate diphosphorylase activity
SPN032672_RS09815	COG2217	Heavy metal translocating P-type atpase
SPN032672_RS09820	COG0028	Belongs to the TPP enzyme family
SPN032672_RS09830	COG2723	6-phospho-beta-galactosidase activity
SPN032672_RS09835	COG1482	cell wall glycoprotein biosynthetic process
SPN032672_RS09840	COG0733	neurotransmitter:sodium symporter activity
SPN032672_RS09860	COG2081	HI0933 family
SPN032672_RS09865	COG1307	EDD domain protein, DegV family
SPN032672_RS09875	COG2131	deaminase
SPN032672_RS09880	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SPN032672_RS09920	COG0517	IMP dehydrogenase activity
SPN032672_RS09920	COG0617	tRNA 3'-terminal CCA addition
SPN032672_RS09920	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPN032672_RS09925	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SPN032672_RS09930	COG2884	Cell division ATP-binding protein ftsE
SPN032672_RS09935	COG2177	Part of the ABC transporter FtsEX involved in
SPN032672_RS09945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN032672_RS09945	COG1263	PTS System
SPN032672_RS09945	COG2190	(PTS) system
SPN032672_RS09955	COG0513	Belongs to the DEAD box helicase family
SPN032672_RS09965	COG0167	dihydroorotate dehydrogenase activity
SPN032672_RS09975	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SPN032672_RS09980	COG4470	Protein conserved in bacteria
SPN032672_RS10010	COG0488	(ABC) transporter
SPN032672_RS10035	COG1837	Belongs to the UPF0109 family
SPN032672_RS10055	COG1328	CTP reductase activity
SPN032672_RS10055	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPN032672_RS10065	COG4443	Transcriptional Coactivator p15 (PC4)
SPN032672_RS10070	COG1268	BioY protein
SPN032672_RS10085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPN032672_RS10090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPN032672_RS10095	COG1136	(ABC) transporter
SPN032672_RS10100	COG0577	efflux transmembrane transporter activity
SPN032672_RS10105	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPN032672_RS10105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPN032672_RS10125	COG4989	oxidoreductase activity
SPN032672_RS10135	COG1028	Short-chain dehydrogenase reductase Sdr
SPN032672_RS10165	COG0745	RESPONSE REGULATOR receiver
SPN032672_RS10170	COG5002	protein histidine kinase activity
SPN032672_RS10190	COG0772	Belongs to the SEDS family
SPN032672_RS10195	COG0693	protein deglycase activity
SPN032672_RS10205	COG0187	DNA topoisomerase II activity
SPN032672_RS10225	COG0494	nUDIX hydrolase
SPN032672_RS10240	COG0542	response to heat
SPN032672_RS10245	COG4703	Protein of unknown function (DUF1797)
SPN032672_RS10250	COG0765	amino acid transport
SPN032672_RS10255	COG1126	abc transporter atp-binding protein
SPN032672_RS10260	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPN032672_RS10265	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SPN032672_RS10285	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SPN032672_RS10325	COG2813	Specifically methylates the guanine in position
SPN032672_RS10330	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SPN032672_RS10340	COG0295	cytidine deaminase activity
SPN032672_RS10345	COG1744	ABC transporter substrate-binding protein PnrA-like
SPN032672_RS10350	COG3845	ABC transporter
SPN032672_RS10355	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPN032672_RS10360	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPN032672_RS10380	COG2801	Transposase and inactivated derivatives
SPN032672_RS10390	COG0187	DNA topoisomerase II activity
SPN032672_RS10400	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPN032672_RS10405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPN032672_RS10410	COG4166	transmembrane transport
SPN032672_RS10445	COG0539	negative regulation of cytoplasmic translation
SPN032672_RS10450	COG1956	GAF domain-containing protein
SPN032672_RS10455	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPN032672_RS10470	COG0719	Fe-S assembly protein
SPN032672_RS10475	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPN032672_RS10485	COG0719	Fe-S assembly protein
SPN032672_RS10490	COG1686	Belongs to the peptidase S11 family
SPN032672_RS10495	COG0628	permease
SPN032672_RS10505	COG1349	DNA-binding transcription factor activity
SPN032672_RS10510	COG1105	Belongs to the carbohydrate kinase PfkB family
SPN032672_RS10515	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPN032672_RS10515	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPN032672_RS10515	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPN032672_RS10520	COG1674	ftsk spoiiie
SPN032672_RS10520	COG0697	spore germination
SPN032672_RS10530	COG1104	cysteine desulfurase activity
SPN032672_RS10570	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
SPN032672_RS10615	COG1737	Transcriptional regulator
SPN032672_RS10620	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SPN032672_RS10625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPN032672_RS10630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPN032672_RS10640	COG4409	exo-alpha-(2->6)-sialidase activity
SPN032672_RS10645	COG0673	inositol 2-dehydrogenase activity
SPN032672_RS10675	COG1269	ATP hydrolysis coupled proton transport
SPN032672_RS10680	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPN032672_RS10730	COG1438	arginine binding
SPN032672_RS10750	COG0469	pyruvate kinase activity
SPN032672_RS10760	COG0582	viral genome integration into host DNA
SPN032672_RS10795	COG3689	TIGRFAM TIGR03943 family protein
SPN032672_RS10800	COG0701	Predicted permease
SPN032672_RS10810	COG2183	response to ionizing radiation
SPN032672_RS10830	COG1136	(ABC) transporter
SPN032672_RS10835	COG0577	efflux transmembrane transporter activity
SPN032672_RS10855	COG1982	Orn Lys Arg decarboxylase major
SPN032672_RS10870	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SPN032672_RS10890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPN032672_RS10895	COG0561	phosphatase activity
SPN032672_RS10915	COG0583	DNA-binding transcription factor activity
SPN032672_RS10920	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPN032672_RS10925	COG0564	pseudouridine synthase activity
SPN032672_RS10930	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPN032672_RS10945	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPN032672_RS10955	COG0470	DNA polymerase III
SPN032672_RS11000	COG0528	UMP kinase activity
SPN032672_RS11010	COG2996	Protein conserved in bacteria
SPN032672_RS11020	COG1702	phosphate starvation-inducible protein PhoH
SPN032672_RS11035	COG0686	Belongs to the AlaDH PNT family
SPN032672_RS11040	COG0686	Belongs to the AlaDH PNT family
SPN032672_RS11045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPN032672_RS11050	COG1596	polysaccharide export
SPN032672_RS11050	COG1555	photosystem II stabilization
SPN032672_RS11055	COG2333	competence protein COMEC
SPN032672_RS11055	COG0658	competence protein
SPN032672_RS11065	COG1131	(ABC) transporter
SPN032672_RS11095	COG0543	2 iron, 2 sulfur cluster binding
SPN032672_RS11100	COG0167	dihydroorotate dehydrogenase activity
SPN032672_RS11105	COG5263	repeat protein
SPN032672_RS11105	COG4193	domain, Protein
SPN032672_RS11110	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPN032672_RS11120	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPN032672_RS11130	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPN032672_RS11135	COG0237	dephospho-CoA kinase activity
SPN032672_RS11140	COG2814	Major facilitator Superfamily
SPN032672_RS11145	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPN032672_RS11155	COG0557	exoribonuclease II activity
SPN032672_RS11165	COG0500	methyltransferase
SPN032672_RS11165	COG3615	Tellurite resistance protein tehB
SPN032672_RS11195	COG4122	O-methyltransferase activity
SPN032672_RS11205	COG2801	Transposase and inactivated derivatives
SPN032672_RS11220	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SPN032672_RS11240	COG0494	nUDIX hydrolase
SPN032672_RS11250	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPN032672_RS11260	COG2176	DNA-directed DNA polymerase activity
SPN032672_RS11265	COG0584	glycerophosphoryl diester phosphodiesterase
SPN032672_RS11285	COG0785	Cytochrome C biogenesis protein
SPN032672_RS11290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPN032672_RS11295	COG0531	amino acid
SPN032672_RS11300	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPN032672_RS11300	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPN032672_RS11340	COG2195	Cleaves the N-terminal amino acid of tripeptides
SPN032672_RS11360	COG0681	Belongs to the peptidase S26 family
SPN032672_RS11370	COG4509	Sortase family
SPN032672_RS11380	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SPN032672_RS11385	COG1970	mechanosensitive ion channel activity
SPN032672_RS11395	COG4708	membrane
SPN032672_RS11410	COG3335	DDE superfamily endonuclease
SPN032672_RS11435	COG0577	efflux transmembrane transporter activity
SPN032672_RS11435	COG1136	(ABC) transporter