locus-tag	class	description
SPN033038_RS00005	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPN033038_RS00020	COG1942	4-Oxalocrotonate Tautomerase
SPN033038_RS00025	COG1435	thymidine kinase activity
SPN033038_RS00035	COG2890	protein-(glutamine-N5) methyltransferase activity
SPN033038_RS00060	COG0741	lytic transglycosylase activity
SPN033038_RS00070	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPN033038_RS00100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPN033038_RS00105	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPN033038_RS00155	COG1597	lipid kinase activity
SPN033038_RS00160	COG0366	Alpha amylase catalytic
SPN033038_RS00200	COG1131	(ABC) transporter
SPN033038_RS00225	COG0772	Belongs to the SEDS family
SPN033038_RS00230	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SPN033038_RS00245	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPN033038_RS00250	COG0358	DNA primase activity
SPN033038_RS00255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPN033038_RS00260	COG2151	metal-sulfur cluster biosynthetic enzyme
SPN033038_RS00265	COG0438	transferase activity, transferring glycosyl groups
SPN033038_RS00270	COG0438	transferase activity, transferring glycosyl groups
SPN033038_RS00295	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPN033038_RS00305	COG4109	DRTGG domain
SPN033038_RS00310	COG0024	Methionine aminopeptidase
SPN033038_RS00330	COG0210	DNA helicase
SPN033038_RS00340	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPN033038_RS00360	COG1104	cysteine desulfurase activity
SPN033038_RS00365	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPN033038_RS00375	COG2357	RelA SpoT domain protein
SPN033038_RS00385	COG0564	pseudouridine synthase activity
SPN033038_RS00390	COG0280	phosphate acetyltransferase
SPN033038_RS00440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPN033038_RS00445	COG1307	EDD domain protein, DegV family
SPN033038_RS00455	COG0488	(ABC) transporter
SPN033038_RS00485	COG1523	belongs to the glycosyl hydrolase 13 family
SPN033038_RS00500	COG1012	belongs to the aldehyde dehydrogenase family
SPN033038_RS00505	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SPN033038_RS00515	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SPN033038_RS00525	COG0560	Phosphoserine phosphatase
SPN033038_RS00530	COG0560	Phosphoserine phosphatase
SPN033038_RS00550	COG4974	Belongs to the 'phage' integrase family
SPN033038_RS00615	COG0582	viral genome integration into host DNA
SPN033038_RS00650	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
SPN033038_RS00650	COG3583	domain protein
SPN033038_RS00655	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPN033038_RS00675	COG0095	Lipoate-protein ligase
SPN033038_RS00680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPN033038_RS00685	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPN033038_RS00690	COG0022	dehydrogenase e1 component
SPN033038_RS00695	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPN033038_RS00700	COG0534	Mate efflux family protein
SPN033038_RS00710	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPN033038_RS00715	COG1051	belongs to the nudix hydrolase family
SPN033038_RS00730	COG1011	Hydrolase
SPN033038_RS00755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPN033038_RS00760	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPN033038_RS00765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPN033038_RS00770	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPN033038_RS00780	COG2723	6-phospho-beta-galactosidase activity
SPN033038_RS00795	COG3711	transcriptional antiterminator
SPN033038_RS00800	COG3684	Belongs to the aldolase LacD family
SPN033038_RS00855	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SPN033038_RS00860	COG0497	DNA recombination
SPN033038_RS00865	COG1438	arginine binding
SPN033038_RS00905	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SPN033038_RS00925	COG3764	Sortase (surface protein transpeptidase)
SPN033038_RS00930	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPN033038_RS00940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SPN033038_RS00955	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPN033038_RS00960	COG5002	protein histidine kinase activity
SPN033038_RS00965	COG0745	RESPONSE REGULATOR receiver
SPN033038_RS00970	COG1194	a g-specific adenine glycosylase
SPN033038_RS00985	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPN033038_RS00990	COG4684	Psort location CytoplasmicMembrane, score
SPN033038_RS01000	COG1827	regulation of RNA biosynthetic process
SPN033038_RS01005	COG2816	NAD+ diphosphatase activity
SPN033038_RS01030	COG0765	amino acid transport
SPN033038_RS01035	COG1126	abc transporter atp-binding protein
SPN033038_RS01040	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPN033038_RS01045	COG0552	protein localization to endoplasmic reticulum
SPN033038_RS01050	COG0561	phosphatase activity
SPN033038_RS01055	COG0561	phosphatase activity
SPN033038_RS01060	COG1196	nuclear chromosome segregation
SPN033038_RS01085	COG1401	restriction endodeoxyribonuclease activity
SPN033038_RS01100	COG0066	3-isopropylmalate dehydratase activity
SPN033038_RS01110	COG0473	3-isopropylmalate dehydrogenase activity
SPN033038_RS01115	COG0473	3-isopropylmalate dehydrogenase activity
SPN033038_RS01130	COG3142	Participates in the control of copper homeostasis
SPN033038_RS01135	COG2832	Protein of unknown function (DUF454)
SPN033038_RS01140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPN033038_RS01150	COG0758	DNA mediated transformation
SPN033038_RS01155	COG4750	Nucleotidyl transferase
SPN033038_RS01170	COG1063	alcohol dehydrogenase
SPN033038_RS01185	COG3475	LICD family
SPN033038_RS01190	COG3475	LICD family
SPN033038_RS01200	COG0505	Belongs to the CarA family
SPN033038_RS01215	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPN033038_RS01230	COG0488	(ABC) transporter
SPN033038_RS01235	COG0501	Belongs to the peptidase M48B family
SPN033038_RS01240	COG1704	LemA family
SPN033038_RS01255	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPN033038_RS01270	COG1078	dGTPase activity
SPN033038_RS01295	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPN033038_RS01300	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPN033038_RS01305	COG1605	Chorismate mutase
SPN033038_RS01305	COG0077	Prephenate dehydratase
SPN033038_RS01310	COG0716	FMN binding
SPN033038_RS01315	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPN033038_RS01345	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPN033038_RS01390	COG0295	cytidine deaminase activity
SPN033038_RS01420	COG0395	ABC-type sugar transport system, permease component
SPN033038_RS01425	COG4209	transmembrane transport
SPN033038_RS01430	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SPN033038_RS01445	COG2801	Transposase and inactivated derivatives
SPN033038_RS01460	COG0577	efflux transmembrane transporter activity
SPN033038_RS01460	COG1136	(ABC) transporter
SPN033038_RS01470	COG1770	oligopeptidase
SPN033038_RS01475	COG0515	serine threonine protein kinase
SPN033038_RS01510	COG0402	S-adenosylhomocysteine deaminase activity
SPN033038_RS01520	COG1132	(ABC) transporter
SPN033038_RS01525	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPN033038_RS01525	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPN033038_RS01560	COG1215	transferase activity, transferring glycosyl groups
SPN033038_RS01570	COG3475	LICD family
SPN033038_RS01585	COG0077	Prephenate dehydratase
SPN033038_RS01590	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SPN033038_RS01595	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SPN033038_RS01605	COG0287	Prephenate dehydrogenase
SPN033038_RS01630	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPN033038_RS01640	COG1131	(ABC) transporter
SPN033038_RS01680	COG3842	ATPase activity
SPN033038_RS01695	COG3527	Alpha-acetolactate decarboxylase
SPN033038_RS01700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPN033038_RS01705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN033038_RS01710	COG0704	Plays a role in the regulation of phosphate uptake
SPN033038_RS01715	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPN033038_RS01720	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPN033038_RS01725	COG0581	inorganic phosphate transmembrane transporter activity
SPN033038_RS01730	COG0573	inorganic phosphate transmembrane transporter activity
SPN033038_RS01735	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPN033038_RS01740	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPN033038_RS01740	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPN033038_RS01745	COG0483	inositol monophosphate 1-phosphatase activity
SPN033038_RS01755	COG1393	Belongs to the ArsC family
SPN033038_RS01765	COG0647	UMP catabolic process
SPN033038_RS01775	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPN033038_RS01835	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPN033038_RS01855	COG1131	(ABC) transporter
SPN033038_RS01860	COG0826	peptidase U32
SPN033038_RS01870	COG0826	peptidase U32
SPN033038_RS01895	COG1132	(ABC) transporter
SPN033038_RS01900	COG1132	(ABC) transporter
SPN033038_RS01915	COG1129	ABC transporter
SPN033038_RS01960	COG2188	Transcriptional regulator
SPN033038_RS01965	COG0697	spore germination
SPN033038_RS01970	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPN033038_RS01985	COG0561	phosphatase activity
SPN033038_RS02015	COG0492	ferredoxin-NADP+ reductase activity
SPN033038_RS02025	COG1126	abc transporter atp-binding protein
SPN033038_RS02035	COG1393	Belongs to the ArsC family
SPN033038_RS02055	COG1272	protein, Hemolysin III
SPN033038_RS02085	COG3976	FMN-binding domain protein
SPN033038_RS02085	COG1053	succinate dehydrogenase
SPN033038_RS02085	COG0431	NADPH-dependent FMN reductase
SPN033038_RS02120	COG0656	L-ascorbic acid biosynthetic process
SPN033038_RS02125	COG0726	polysaccharide deacetylase
SPN033038_RS02150	COG3335	DDE superfamily endonuclease
SPN033038_RS02165	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPN033038_RS02215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPN033038_RS02225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN033038_RS02230	COG1126	abc transporter atp-binding protein
SPN033038_RS02245	COG0628	permease
SPN033038_RS02250	COG2706	6-phosphogluconolactonase activity
SPN033038_RS02310	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPN033038_RS02335	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPN033038_RS02340	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SPN033038_RS02345	COG0626	cystathionine gamma-synthase activity
SPN033038_RS02355	COG1132	(ABC) transporter
SPN033038_RS02360	COG1132	(ABC) transporter
SPN033038_RS02365	COG4166	transmembrane transport
SPN033038_RS02370	COG2244	polysaccharide biosynthetic process
SPN033038_RS02375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPN033038_RS02405	COG2827	Endonuclease containing a URI domain
SPN033038_RS02410	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPN033038_RS02415	COG1098	S1 RNA binding domain
SPN033038_RS02425	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPN033038_RS02430	COG0629	single-stranded DNA binding
SPN033038_RS02440	COG0017	Asparaginyl-tRNA synthetase
SPN033038_RS02450	COG0436	Aminotransferase
SPN033038_RS02475	COG3711	transcriptional antiterminator
SPN033038_RS02495	COG0242	peptide deformylase activity
SPN033038_RS02500	COG0625	glutathione transferase activity
SPN033038_RS02510	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPN033038_RS02515	COG0488	(ABC) transporter
SPN033038_RS02520	COG0617	tRNA 3'-terminal CCA addition
SPN033038_RS02530	COG1307	EDD domain protein, DegV family
SPN033038_RS02550	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPN033038_RS02570	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SPN033038_RS02580	COG0251	oxidation-reduction process
SPN033038_RS02600	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPN033038_RS02610	COG5263	repeat protein
SPN033038_RS02610	COG4193	domain, Protein
SPN033038_RS02620	COG3935	DnaD domain protein
SPN033038_RS02635	COG2226	methyltransferase
SPN033038_RS02640	COG3842	ATPase activity
SPN033038_RS02650	COG1335	isochorismatase
SPN033038_RS02660	COG0513	Belongs to the DEAD box helicase family
SPN033038_RS02680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPN033038_RS02685	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPN033038_RS02690	COG3442	glutamine amidotransferase
SPN033038_RS02695	COG0006	proline dipeptidase activity
SPN033038_RS02705	COG2801	Transposase and inactivated derivatives
SPN033038_RS02720	COG4720	Psort location CytoplasmicMembrane, score
SPN033038_RS02725	COG0351	phosphomethylpyrimidine kinase
SPN033038_RS02750	COG2824	Alkylphosphonate utilization operon protein PhnA
SPN033038_RS02775	COG0463	Glycosyl transferase, family 2
SPN033038_RS02780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPN033038_RS02790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPN033038_RS02795	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SPN033038_RS02800	COG2384	SAM-dependent methyltransferase
SPN033038_RS02805	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SPN033038_RS02810	COG0204	Acyl-transferase
SPN033038_RS02825	COG2910	NAD(P)H-binding
SPN033038_RS02850	COG5002	protein histidine kinase activity
SPN033038_RS02855	COG0745	RESPONSE REGULATOR receiver
SPN033038_RS02870	COG1959	2 iron, 2 sulfur cluster binding
SPN033038_RS02955	COG3590	peptidase
SPN033038_RS02975	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPN033038_RS02980	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SPN033038_RS02995	COG0577	efflux transmembrane transporter activity
SPN033038_RS02995	COG1136	(ABC) transporter
SPN033038_RS03040	COG3599	regulation of cell shape
SPN033038_RS03060	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPN033038_RS03080	COG1051	belongs to the nudix hydrolase family
SPN033038_RS03085	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPN033038_RS03100	COG0768	penicillin binding
SPN033038_RS03115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPN033038_RS03135	COG2731	YhcH YjgK YiaL family protein
SPN033038_RS03140	COG0395	ABC-type sugar transport system, permease component
SPN033038_RS03145	COG1175	transmembrane transport
SPN033038_RS03155	COG1263	PTS System
SPN033038_RS03155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN033038_RS03155	COG2190	(PTS) system
SPN033038_RS03165	COG0673	inositol 2-dehydrogenase activity
SPN033038_RS03170	COG4409	exo-alpha-(2->6)-sialidase activity
SPN033038_RS03180	COG1175	transmembrane transport
SPN033038_RS03185	COG1653	transport
SPN033038_RS03205	COG3458	cephalosporin-C deacetylase activity
SPN033038_RS03210	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPN033038_RS03225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPN033038_RS03230	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPN033038_RS03235	COG0653	protein targeting
SPN033038_RS03245	COG1131	(ABC) transporter
SPN033038_RS03275	COG0778	Nitroreductase
SPN033038_RS03280	COG1484	DNA-dependent DNA replication
SPN033038_RS03295	COG1725	Transcriptional regulator
SPN033038_RS03300	COG1131	(ABC) transporter
SPN033038_RS03310	COG1668	transmembrane transport
SPN033038_RS03315	COG4152	abc transporter atp-binding protein
SPN033038_RS03335	COG1940	carbohydrate kinase activity
SPN033038_RS03340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN033038_RS03340	COG2190	(PTS) system
SPN033038_RS03340	COG1263	PTS System
SPN033038_RS03350	COG1621	beta-fructofuranosidase activity
SPN033038_RS03355	COG1609	Transcriptional regulator
SPN033038_RS03365	COG3425	synthase
SPN033038_RS03390	COG0515	serine threonine protein kinase
SPN033038_RS03390	COG2815	serine threonine protein kinase
SPN033038_RS03395	COG0631	protein serine/threonine phosphatase activity
SPN033038_RS03400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPN033038_RS03400	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPN033038_RS03410	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPN033038_RS03420	COG0194	GDP metabolic process
SPN033038_RS03450	COG0799	negative regulation of ribosome biogenesis
SPN033038_RS03460	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPN033038_RS03465	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SPN033038_RS03470	COG1534	Rna-binding protein
SPN033038_RS03475	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPN033038_RS03490	COG0668	transmembrane transport
SPN033038_RS03520	COG0438	transferase activity, transferring glycosyl groups
SPN033038_RS03525	COG0438	transferase activity, transferring glycosyl groups
SPN033038_RS03530	COG0653	protein targeting
SPN033038_RS03550	COG0201	protein transport
SPN033038_RS03555	COG1215	transferase activity, transferring glycosyl groups
SPN033038_RS03560	COG1215	transferase activity, transferring glycosyl groups
SPN033038_RS03565	COG1442	glycosyl transferase family 8
SPN033038_RS03570	COG1442	glycosyl transferase family 8
SPN033038_RS03575	COG1442	glycosyl transferase family 8
SPN033038_RS03580	COG0438	transferase activity, transferring glycosyl groups
SPN033038_RS03585	COG1442	glycosyl transferase family 8
SPN033038_RS03585	COG1216	Glycosyl transferase, family 2
SPN033038_RS03590	COG1442	glycosyl transferase family 8
SPN033038_RS03595	COG1216	Glycosyl transferase, family 2
SPN033038_RS03595	COG1442	glycosyl transferase family 8
SPN033038_RS03600	COG1442	glycosyl transferase family 8
SPN033038_RS03600	COG1216	Glycosyl transferase, family 2
SPN033038_RS03625	COG3118	belongs to the thioredoxin family
SPN033038_RS03630	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SPN033038_RS03635	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPN033038_RS03650	COG1164	Oligoendopeptidase f
SPN033038_RS03655	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPN033038_RS03660	COG2264	protein methyltransferase activity
SPN033038_RS03665	COG1051	belongs to the nudix hydrolase family
SPN033038_RS03710	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPN033038_RS03720	COG1621	beta-fructofuranosidase activity
SPN033038_RS03725	COG0395	ABC-type sugar transport system, permease component
SPN033038_RS03740	COG1175	transmembrane transport
SPN033038_RS03750	COG1609	Transcriptional regulator
SPN033038_RS03755	COG3711	transcriptional antiterminator
SPN033038_RS03780	COG3237	CsbD-like
SPN033038_RS03800	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPN033038_RS03810	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN033038_RS03815	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPN033038_RS03820	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN033038_RS03835	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN033038_RS03840	COG1940	carbohydrate kinase activity
SPN033038_RS03840	COG1846	Transcriptional regulator
SPN033038_RS03850	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SPN033038_RS03890	COG0512	Glutamine amidotransferase of anthranilate synthase
SPN033038_RS03895	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPN033038_RS03920	COG1285	pathogenesis
SPN033038_RS03925	COG1178	ABC-type Fe3 transport system permease component
SPN033038_RS03955	COG5434	Belongs to the glycosyl hydrolase 28 family
SPN033038_RS03970	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SPN033038_RS03975	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPN033038_RS03980	COG1132	(ABC) transporter
SPN033038_RS03985	COG1132	(ABC) transporter
SPN033038_RS04010	COG0708	Exodeoxyribonuclease III
SPN033038_RS04030	COG2233	PERMEase
SPN033038_RS04060	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPN033038_RS04065	COG1609	Transcriptional regulator
SPN033038_RS04070	COG1063	alcohol dehydrogenase
SPN033038_RS04075	COG0789	Transcriptional regulator
SPN033038_RS04080	COG1230	cation diffusion facilitator family transporter
SPN033038_RS04090	COG3201	nicotinamide mononucleotide transporter
SPN033038_RS04095	COG1174	glycine betaine transport
SPN033038_RS04120	COG1363	Peptidase, m42
SPN033038_RS04135	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPN033038_RS04140	COG4605	iron ion homeostasis
SPN033038_RS04145	COG4604	ABC transporter, ATP-binding protein
SPN033038_RS04150	COG4607	ABC-type enterochelin transport system periplasmic component
SPN033038_RS04160	COG1187	pseudouridine synthase activity
SPN033038_RS04180	COG0517	IMP dehydrogenase activity
SPN033038_RS04190	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SPN033038_RS04205	COG0366	Alpha amylase catalytic
SPN033038_RS04210	COG1263	PTS System
SPN033038_RS04210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN033038_RS04215	COG2188	Transcriptional regulator
SPN033038_RS04220	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPN033038_RS04240	COG4608	Belongs to the ABC transporter superfamily
SPN033038_RS04245	COG0444	Belongs to the ABC transporter superfamily
SPN033038_RS04250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPN033038_RS04255	COG0601	transmembrane transport
SPN033038_RS04260	COG4166	transmembrane transport
SPN033038_RS04270	COG0366	Alpha amylase catalytic
SPN033038_RS04280	COG0395	ABC-type sugar transport system, permease component
SPN033038_RS04285	COG1175	transmembrane transport
SPN033038_RS04290	COG1653	transport
SPN033038_RS04295	COG3345	alpha-galactosidase
SPN033038_RS04300	COG2207	Transcriptional regulator
SPN033038_RS04305	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPN033038_RS04305	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPN033038_RS04425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPN033038_RS04460	COG4221	oxidoreductase activity
SPN033038_RS04465	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPN033038_RS04470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPN033038_RS04505	COG1132	(ABC) transporter
SPN033038_RS04595	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPN033038_RS04595	COG5263	repeat protein
SPN033038_RS04625	COG1316	TRANSCRIPTIONal
SPN033038_RS04635	COG0802	atpase or kinase
SPN033038_RS04665	COG1136	(ABC) transporter
SPN033038_RS04695	COG1253	flavin adenine dinucleotide binding
SPN033038_RS04710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPN033038_RS04720	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPN033038_RS04725	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SPN033038_RS04730	COG0742	ribosomal rna small subunit methyltransferase
SPN033038_RS04750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPN033038_RS04755	COG1254	Belongs to the acylphosphatase family
SPN033038_RS04765	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPN033038_RS04775	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPN033038_RS04790	COG1564	THIamine pyrophosphokinase
SPN033038_RS04800	COG1162	GTPase activity
SPN033038_RS04840	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SPN033038_RS04845	COG0084	hydrolase, TatD family'
SPN033038_RS04865	COG0436	Aminotransferase
SPN033038_RS04875	COG0589	response to stress
SPN033038_RS04880	COG0561	phosphatase activity
SPN033038_RS04885	COG0252	asparaginase activity
SPN033038_RS04895	COG1609	Transcriptional regulator
SPN033038_RS04900	COG2197	response regulator
SPN033038_RS04905	COG4585	Histidine kinase
SPN033038_RS04910	COG0842	Transport permease protein
SPN033038_RS04915	COG1131	(ABC) transporter
SPN033038_RS05005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPN033038_RS05010	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SPN033038_RS05035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPN033038_RS05040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPN033038_RS05050	COG0012	GTP binding
SPN033038_RS05060	COG0592	DNA-directed DNA polymerase activity
SPN033038_RS05070	COG1475	DNA binding
SPN033038_RS05075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPN033038_RS05120	COG1511	domain protein
SPN033038_RS05140	COG2801	Transposase and inactivated derivatives
SPN033038_RS05150	COG0488	(ABC) transporter
SPN033038_RS05155	COG0180	Tryptophanyl-tRNA synthetase
SPN033038_RS05160	COG0516	GMP reductase activity
SPN033038_RS05160	COG0517	IMP dehydrogenase activity
SPN033038_RS05170	COG2501	S4 domain
SPN033038_RS05175	COG0612	Peptidase, M16
SPN033038_RS05180	COG0612	Peptidase, M16
SPN033038_RS05190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPN033038_RS05195	COG1122	ATPase activity
SPN033038_RS05200	COG1122	ATPase activity
SPN033038_RS05205	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPN033038_RS05210	COG1792	Involved in formation and maintenance of cell shape
SPN033038_RS05220	COG3942	CHAP domain
SPN033038_RS05240	COG3335	DDE superfamily endonuclease
SPN033038_RS05255	COG1739	Uncharacterized protein family UPF0029
SPN033038_RS05260	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPN033038_RS05265	COG1040	competence protein
SPN033038_RS05285	COG0305	Participates in initiation and elongation during chromosome replication
SPN033038_RS05305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SPN033038_RS05310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SPN033038_RS05315	COG1116	anion transmembrane transporter activity
SPN033038_RS05320	COG4463	regulation of RNA biosynthetic process
SPN033038_RS05325	COG0542	response to heat
SPN033038_RS05330	COG0745	RESPONSE REGULATOR receiver
SPN033038_RS05335	COG5002	protein histidine kinase activity
SPN033038_RS05340	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPN033038_RS05345	COG0366	Alpha amylase catalytic
SPN033038_RS05355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPN033038_RS05375	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SPN033038_RS05380	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPN033038_RS05400	COG3344	reverse transcriptase
SPN033038_RS05420	COG1696	Membrane protein involved in D-alanine export
SPN033038_RS05430	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPN033038_RS05435	COG1846	Transcriptional regulator
SPN033038_RS05440	COG1121	(ABC) transporter
SPN033038_RS05445	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPN033038_RS05450	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPN033038_RS05450	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPN033038_RS05460	COG1070	Carbohydrate kinase
SPN033038_RS05480	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN033038_RS05490	COG3716	PTS system mannose fructose sorbose family IID component
SPN033038_RS05525	COG1454	alcohol dehydrogenase
SPN033038_RS05535	COG3064	Membrane
SPN033038_RS05535	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPN033038_RS05535	COG3583	domain protein
SPN033038_RS05550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPN033038_RS05555	COG1288	antiporter activity
SPN033038_RS05560	COG0549	Belongs to the carbamate kinase family
SPN033038_RS05580	COG3537	Alpha-1,2-mannosidase
SPN033038_RS05590	COG0383	alpha-mannosidase activity
SPN033038_RS05630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPN033038_RS05650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPN033038_RS05665	COG3959	Transketolase, thiamine diphosphate binding domain
SPN033038_RS05670	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPN033038_RS05680	COG2151	metal-sulfur cluster biosynthetic enzyme
SPN033038_RS05695	COG0124	histidyl-tRNA synthetase
SPN033038_RS05710	COG1476	TRANSCRIPTIONal
SPN033038_RS05745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPN033038_RS05755	COG1609	Transcriptional regulator
SPN033038_RS05760	COG5521	maltodextrose utilization protein MalA
SPN033038_RS05770	COG3833	ABC-type maltose transport systems, permease component
SPN033038_RS05775	COG1175	transmembrane transport
SPN033038_RS05780	COG2182	Extracellular solute-binding protein
SPN033038_RS05785	COG1640	4-alpha-glucanotransferase
SPN033038_RS05790	COG0058	SHG alpha-glucan phosphorylase activity
SPN033038_RS05810	COG2226	methyltransferase
SPN033038_RS05820	COG2217	Heavy metal translocating P-type atpase
SPN033038_RS05830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPN033038_RS05830	COG4499	WXG100 protein secretion system (Wss), protein YukC
SPN033038_RS05835	COG0697	spore germination
SPN033038_RS05850	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPN033038_RS05860	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPN033038_RS05880	COG0704	Plays a role in the regulation of phosphate uptake
SPN033038_RS05885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPN033038_RS05895	COG0573	inorganic phosphate transmembrane transporter activity
SPN033038_RS05900	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPN033038_RS05905	COG5002	protein histidine kinase activity
SPN033038_RS05910	COG0745	RESPONSE REGULATOR receiver
SPN033038_RS05930	COG1438	arginine binding
SPN033038_RS05940	COG1132	(ABC) transporter
SPN033038_RS05950	COG1132	(ABC) transporter
SPN033038_RS05955	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPN033038_RS06070	COG0534	Mate efflux family protein
SPN033038_RS06075	COG0131	Imidazoleglycerol-phosphate dehydratase
SPN033038_RS06075	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SPN033038_RS06090	COG3759	membrane
SPN033038_RS06095	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SPN033038_RS06120	COG1063	alcohol dehydrogenase
SPN033038_RS06130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPN033038_RS06135	COG1459	type II secretion system
SPN033038_RS06140	COG4537	Required for transformation and DNA binding
SPN033038_RS06195	COG0706	membrane insertase activity
SPN033038_RS06200	COG1847	R3H domain protein
SPN033038_RS06210	COG3037	sugar-specific permease SgaT UlaA
SPN033038_RS06220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPN033038_RS06230	COG3623	hexulose-6-phosphate isomerase
SPN033038_RS06250	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SPN033038_RS06260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPN033038_RS06275	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPN033038_RS06285	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN033038_RS06290	COG2723	6-phospho-beta-galactosidase activity
SPN033038_RS06295	COG2188	Transcriptional regulator
SPN033038_RS06300	COG4133	protoheme IX ABC transporter activity
SPN033038_RS06310	COG0157	Belongs to the NadC ModD family
SPN033038_RS06325	COG0577	efflux transmembrane transporter activity
SPN033038_RS06335	COG0564	pseudouridine synthase activity
SPN033038_RS06340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPN033038_RS06345	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPN033038_RS06410	COG3335	DDE superfamily endonuclease
SPN033038_RS06445	COG0756	dUTP diphosphatase activity
SPN033038_RS06455	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SPN033038_RS06470	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPN033038_RS06495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPN033038_RS06495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPN033038_RS06500	COG1832	CoA-binding protein
SPN033038_RS06510	COG2855	membrane
SPN033038_RS06515	COG0436	Aminotransferase
SPN033038_RS06530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPN033038_RS06550	COG2274	protein secretion by the type I secretion system
SPN033038_RS06555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPN033038_RS06565	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPN033038_RS06570	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SPN033038_RS06580	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPN033038_RS06595	COG0151	Belongs to the GarS family
SPN033038_RS06600	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPN033038_RS06615	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPN033038_RS06620	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPN033038_RS06620	COG3583	domain protein
SPN033038_RS06620	COG3064	Membrane
SPN033038_RS06635	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN033038_RS06640	COG3715	PTS system
SPN033038_RS06645	COG3716	PTS system mannose fructose sorbose family IID component
SPN033038_RS06655	COG2222	sugar isomerase
SPN033038_RS06665	COG2514	catechol 2,3-dioxygenase activity
SPN033038_RS06670	COG1937	Protein conserved in bacteria
SPN033038_RS06695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPN033038_RS06700	COG0569	domain protein
SPN033038_RS06710	COG1215	transferase activity, transferring glycosyl groups
SPN033038_RS06730	COG5002	protein histidine kinase activity
SPN033038_RS06750	COG4209	transmembrane transport
SPN033038_RS06755	COG0395	ABC-type sugar transport system, permease component
SPN033038_RS06760	COG1653	transport
SPN033038_RS06790	COG1695	Transcriptional regulator
SPN033038_RS06815	COG0546	phosphoglycolate phosphatase activity
SPN033038_RS06820	COG1760	l-serine dehydratase
SPN033038_RS06825	COG1760	l-serine dehydratase
SPN033038_RS06930	COG0445	tRNA wobble uridine modification
SPN033038_RS06965	COG1214	PFAM Peptidase M22, glycoprotease
SPN033038_RS07000	COG0438	transferase activity, transferring glycosyl groups
SPN033038_RS07045	COG1396	sequence-specific DNA binding
SPN033038_RS07085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN033038_RS07095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN033038_RS07100	COG1464	Belongs to the NlpA lipoprotein family
SPN033038_RS07105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPN033038_RS07110	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPN033038_RS07130	COG2972	Histidine kinase
SPN033038_RS07135	COG4753	response regulator
SPN033038_RS07135	COG2207	Transcriptional regulator
SPN033038_RS07145	COG1780	Probably involved in ribonucleotide reductase function
SPN033038_RS07180	COG0019	diaminopimelate decarboxylase activity
SPN033038_RS07210	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPN033038_RS07210	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPN033038_RS07230	COG2818	Glycosylase
SPN033038_RS07255	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPN033038_RS07260	COG0006	proline dipeptidase activity
SPN033038_RS07270	COG1393	Belongs to the ArsC family
SPN033038_RS07295	COG0285	dihydrofolate synthase activity
SPN033038_RS07305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPN033038_RS07370	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPN033038_RS07395	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SPN033038_RS07435	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SPN033038_RS07450	COG0201	protein transport
SPN033038_RS07465	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SPN033038_RS07470	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SPN033038_RS07480	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SPN033038_RS07485	COG0202	RNA polymerase activity
SPN033038_RS07495	COG3830	Belongs to the UPF0237 family
SPN033038_RS07535	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPN033038_RS07540	COG1349	DNA-binding transcription factor activity
SPN033038_RS07550	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPN033038_RS07555	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN033038_RS07560	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN033038_RS07565	COG1882	Formate acetyltransferase
SPN033038_RS07610	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPN033038_RS07615	COG4589	Belongs to the CDS family
SPN033038_RS07620	COG0750	zinc metalloprotease
SPN033038_RS07630	COG2723	6-phospho-beta-galactosidase activity
SPN033038_RS07635	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPN033038_RS07645	COG1523	belongs to the glycosyl hydrolase 13 family
SPN033038_RS07665	COG2176	DNA-directed DNA polymerase activity
SPN033038_RS07685	COG2309	aminopeptidase activity
SPN033038_RS07690	COG2261	transglycosylase associated protein
SPN033038_RS07695	COG1187	pseudouridine synthase activity
SPN033038_RS07705	COG3579	cysteine-type endopeptidase activity
SPN033038_RS07710	COG3716	PTS system mannose fructose sorbose family IID component
SPN033038_RS07715	COG3715	PTS system
SPN033038_RS07725	COG1064	alcohol dehydrogenase
SPN033038_RS07730	COG0561	phosphatase activity
SPN033038_RS07735	COG2252	PERMEase
SPN033038_RS07745	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SPN033038_RS07750	COG0285	dihydrofolate synthase activity
SPN033038_RS07760	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SPN033038_RS07760	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPN033038_RS07775	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPN033038_RS07795	COG2723	6-phospho-beta-galactosidase activity
SPN033038_RS07810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPN033038_RS07810	COG3711	transcriptional antiterminator
SPN033038_RS07825	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN033038_RS07840	COG0386	Belongs to the glutathione peroxidase family
SPN033038_RS07845	COG5492	domain, Protein
SPN033038_RS07870	COG1028	Short-chain dehydrogenase reductase Sdr
SPN033038_RS07880	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SPN033038_RS07885	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN033038_RS07890	COG3715	PTS system
SPN033038_RS07895	COG3716	PTS system mannose fructose sorbose family IID component
SPN033038_RS07910	COG1609	Transcriptional regulator
SPN033038_RS07940	COG4839	cell division protein FtsL
SPN033038_RS07945	COG0768	penicillin binding
SPN033038_RS08020	COG3344	reverse transcriptase
SPN033038_RS08035	COG0366	Alpha amylase catalytic
SPN033038_RS08040	COG4166	transmembrane transport
SPN033038_RS08080	COG3944	biosynthesis protein
SPN033038_RS08140	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SPN033038_RS08150	COG1088	dTDP-glucose 4,6-dehydratase activity
SPN033038_RS08165	COG4372	Transposase
SPN033038_RS08170	COG4166	transmembrane transport
SPN033038_RS08175	COG0366	Alpha amylase catalytic
SPN033038_RS08180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPN033038_RS08205	COG0116	Belongs to the methyltransferase superfamily
SPN033038_RS08215	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SPN033038_RS08220	COG0745	RESPONSE REGULATOR receiver
SPN033038_RS08270	COG4585	Histidine kinase
SPN033038_RS08275	COG2197	response regulator
SPN033038_RS08305	COG0582	viral genome integration into host DNA
SPN033038_RS08315	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPN033038_RS08320	COG0681	Belongs to the peptidase S26 family
SPN033038_RS08345	COG1115	amino acid carrier protein
SPN033038_RS08370	COG0527	aspartate kinase activity
SPN033038_RS08375	COG1024	Enoyl-CoA hydratase
SPN033038_RS08380	COG1846	Transcriptional regulator
SPN033038_RS08390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPN033038_RS08400	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPN033038_RS08405	COG1028	Short-chain dehydrogenase reductase Sdr
SPN033038_RS08410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPN033038_RS08425	COG0439	Biotin carboxylase
SPN033038_RS08430	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPN033038_RS08465	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SPN033038_RS08490	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SPN033038_RS08500	COG1461	Dihydroxyacetone kinase
SPN033038_RS08505	COG0028	Belongs to the TPP enzyme family
SPN033038_RS08510	COG0440	acetolactate synthase activity
SPN033038_RS08530	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SPN033038_RS08555	COG0765	amino acid transport
SPN033038_RS08580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPN033038_RS08585	COG1882	Formate acetyltransferase
SPN033038_RS08615	COG1846	Transcriptional regulator
SPN033038_RS08615	COG1940	carbohydrate kinase activity
SPN033038_RS08620	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN033038_RS08630	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPN033038_RS08635	COG2723	6-phospho-beta-galactosidase activity
SPN033038_RS08640	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN033038_RS08640	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN033038_RS08645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPN033038_RS08650	COG0569	domain protein
SPN033038_RS08670	COG1122	ATPase activity
SPN033038_RS08685	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPN033038_RS08690	COG0671	phosphoesterase, PA-phosphatase related
SPN033038_RS08710	COG1132	(ABC) transporter
SPN033038_RS08725	COG1247	-acetyltransferase
SPN033038_RS08735	COG0504	CTP synthase activity
SPN033038_RS08740	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPN033038_RS08760	COG0789	Transcriptional regulator
SPN033038_RS08765	COG0174	glutamine synthetase
SPN033038_RS08775	COG0732	type I restriction modification DNA specificity domain
SPN033038_RS08780	COG0732	type I restriction modification DNA specificity domain
SPN033038_RS08820	COG0484	heat shock protein binding
SPN033038_RS08835	COG0537	adenosine 5'-monophosphoramidase activity
SPN033038_RS08840	COG1131	(ABC) transporter
SPN033038_RS08865	COG3290	protein histidine kinase activity
SPN033038_RS08875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPN033038_RS08880	COG2274	protein secretion by the type I secretion system
SPN033038_RS08885	COG2274	protein secretion by the type I secretion system
SPN033038_RS08980	COG1266	CAAX protease self-immunity
SPN033038_RS09000	COG0195	Participates in both transcription termination and antitermination
SPN033038_RS09005	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPN033038_RS09085	COG0519	Catalyzes the synthesis of GMP from XMP
SPN033038_RS09095	COG0525	valine-tRNA ligase activity
SPN033038_RS09110	COG2801	Transposase and inactivated derivatives
SPN033038_RS09115	COG2801	Transposase and inactivated derivatives
SPN033038_RS09135	COG3711	transcriptional antiterminator
SPN033038_RS09140	COG2190	(PTS) system
SPN033038_RS09140	COG1263	PTS System
SPN033038_RS09140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN033038_RS09155	COG0456	acetyltransferase
SPN033038_RS09160	COG0072	phenylalanine-tRNA ligase activity
SPN033038_RS09160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPN033038_RS09175	COG3620	sequence-specific DNA binding
SPN033038_RS09195	COG1045	serine acetyltransferase
SPN033038_RS09205	COG0215	cysteine-tRNA ligase activity
SPN033038_RS09210	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPN033038_RS09245	COG0577	efflux transmembrane transporter activity
SPN033038_RS09250	COG1136	(ABC) transporter
SPN033038_RS09255	COG0577	efflux transmembrane transporter activity
SPN033038_RS09260	COG0745	RESPONSE REGULATOR receiver
SPN033038_RS09265	COG5002	protein histidine kinase activity
SPN033038_RS09270	COG0191	fructose-bisphosphate aldolase activity
SPN033038_RS09275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SPN033038_RS09280	COG0765	amino acid transport
SPN033038_RS09285	COG0765	amino acid transport
SPN033038_RS09290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN033038_RS09300	COG1126	abc transporter atp-binding protein
SPN033038_RS09305	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPN033038_RS09305	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPN033038_RS09345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN033038_RS09360	COG1573	uracil-dna glycosylase
SPN033038_RS09370	COG1114	Component of the transport system for branched-chain amino acids
SPN033038_RS09375	COG1363	Peptidase, m42
SPN033038_RS09415	COG4555	ABC transporter
SPN033038_RS09450	COG1404	Belongs to the peptidase S8 family
SPN033038_RS09455	COG4372	Transposase
SPN033038_RS09470	COG3775	system Galactitol-specific IIC component
SPN033038_RS09480	COG3250	beta-galactosidase activity
SPN033038_RS09500	COG1242	4 iron, 4 sulfur cluster binding
SPN033038_RS09505	COG1242	4 iron, 4 sulfur cluster binding
SPN033038_RS09510	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPN033038_RS09530	COG0785	Cytochrome C biogenesis protein
SPN033038_RS09535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPN033038_RS09540	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPN033038_RS09540	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPN033038_RS09545	COG4753	response regulator
SPN033038_RS09545	COG2207	Transcriptional regulator
SPN033038_RS09550	COG2972	Histidine kinase
SPN033038_RS09560	COG3064	Membrane
SPN033038_RS09565	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPN033038_RS09580	COG1940	carbohydrate kinase activity
SPN033038_RS09600	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPN033038_RS09605	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPN033038_RS09615	COG0300	oxidoreductase activity
SPN033038_RS09630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPN033038_RS09640	COG1187	pseudouridine synthase activity
SPN033038_RS09645	COG1217	gtp-binding protein TYPA
SPN033038_RS09665	COG1136	(ABC) transporter
SPN033038_RS09680	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SPN033038_RS09710	COG2826	transposase and inactivated derivatives, IS30 family
SPN033038_RS09720	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SPN033038_RS09745	COG1131	(ABC) transporter
SPN033038_RS09755	COG1126	abc transporter atp-binding protein
SPN033038_RS09760	COG1129	ABC transporter
SPN033038_RS09765	COG4215	(ABC) transporter
SPN033038_RS09770	COG0765	amino acid transport
SPN033038_RS09775	COG1304	FMN binding
SPN033038_RS09780	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SPN033038_RS09785	COG1304	FMN binding
SPN033038_RS09795	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SPN033038_RS09800	COG0352	thiamine-phosphate diphosphorylase activity
SPN033038_RS09810	COG4172	Belongs to the ABC transporter superfamily
SPN033038_RS09820	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SPN033038_RS09835	COG0352	thiamine-phosphate diphosphorylase activity
SPN033038_RS09855	COG2217	Heavy metal translocating P-type atpase
SPN033038_RS09860	COG0028	Belongs to the TPP enzyme family
SPN033038_RS09870	COG2723	6-phospho-beta-galactosidase activity
SPN033038_RS09875	COG1482	cell wall glycoprotein biosynthetic process
SPN033038_RS09880	COG0733	neurotransmitter:sodium symporter activity
SPN033038_RS09900	COG2081	HI0933 family
SPN033038_RS09905	COG1307	EDD domain protein, DegV family
SPN033038_RS09915	COG2131	deaminase
SPN033038_RS09920	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SPN033038_RS09965	COG0617	tRNA 3'-terminal CCA addition
SPN033038_RS09965	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPN033038_RS09965	COG0517	IMP dehydrogenase activity
SPN033038_RS09970	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SPN033038_RS09975	COG2884	Cell division ATP-binding protein ftsE
SPN033038_RS09980	COG2177	Part of the ABC transporter FtsEX involved in
SPN033038_RS09990	COG1263	PTS System
SPN033038_RS09990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN033038_RS09990	COG2190	(PTS) system
SPN033038_RS10000	COG0513	Belongs to the DEAD box helicase family
SPN033038_RS10010	COG0167	dihydroorotate dehydrogenase activity
SPN033038_RS10020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SPN033038_RS10025	COG4470	Protein conserved in bacteria
SPN033038_RS10055	COG0488	(ABC) transporter
SPN033038_RS10080	COG1837	Belongs to the UPF0109 family
SPN033038_RS10100	COG1328	CTP reductase activity
SPN033038_RS10100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPN033038_RS10110	COG4443	Transcriptional Coactivator p15 (PC4)
SPN033038_RS10115	COG1268	BioY protein
SPN033038_RS10130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPN033038_RS10135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPN033038_RS10140	COG1136	(ABC) transporter
SPN033038_RS10145	COG0577	efflux transmembrane transporter activity
SPN033038_RS10150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPN033038_RS10150	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPN033038_RS10170	COG4989	oxidoreductase activity
SPN033038_RS10180	COG1028	Short-chain dehydrogenase reductase Sdr
SPN033038_RS10210	COG0745	RESPONSE REGULATOR receiver
SPN033038_RS10215	COG5002	protein histidine kinase activity
SPN033038_RS10235	COG0772	Belongs to the SEDS family
SPN033038_RS10240	COG0693	protein deglycase activity
SPN033038_RS10250	COG0187	DNA topoisomerase II activity
SPN033038_RS10270	COG0494	nUDIX hydrolase
SPN033038_RS10285	COG0542	response to heat
SPN033038_RS10290	COG4703	Protein of unknown function (DUF1797)
SPN033038_RS10295	COG0765	amino acid transport
SPN033038_RS10300	COG1126	abc transporter atp-binding protein
SPN033038_RS10305	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPN033038_RS10310	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SPN033038_RS10330	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SPN033038_RS10370	COG2813	Specifically methylates the guanine in position
SPN033038_RS10375	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SPN033038_RS10385	COG0295	cytidine deaminase activity
SPN033038_RS10390	COG1744	ABC transporter substrate-binding protein PnrA-like
SPN033038_RS10400	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPN033038_RS10405	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPN033038_RS10425	COG2801	Transposase and inactivated derivatives
SPN033038_RS10445	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPN033038_RS10450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPN033038_RS10455	COG4166	transmembrane transport
SPN033038_RS10490	COG0539	negative regulation of cytoplasmic translation
SPN033038_RS10495	COG1956	GAF domain-containing protein
SPN033038_RS10500	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPN033038_RS10515	COG0719	Fe-S assembly protein
SPN033038_RS10520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPN033038_RS10530	COG0719	Fe-S assembly protein
SPN033038_RS10535	COG1686	Belongs to the peptidase S11 family
SPN033038_RS10540	COG0628	permease
SPN033038_RS10550	COG1349	DNA-binding transcription factor activity
SPN033038_RS10555	COG1105	Belongs to the carbohydrate kinase PfkB family
SPN033038_RS10560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPN033038_RS10560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPN033038_RS10560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPN033038_RS10565	COG0697	spore germination
SPN033038_RS10565	COG1674	ftsk spoiiie
SPN033038_RS10575	COG1104	cysteine desulfurase activity
SPN033038_RS10615	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
SPN033038_RS10660	COG1737	Transcriptional regulator
SPN033038_RS10665	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SPN033038_RS10670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPN033038_RS10675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPN033038_RS10685	COG4409	exo-alpha-(2->6)-sialidase activity
SPN033038_RS10690	COG0673	inositol 2-dehydrogenase activity
SPN033038_RS10720	COG1269	ATP hydrolysis coupled proton transport
SPN033038_RS10725	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPN033038_RS10775	COG1438	arginine binding
SPN033038_RS10795	COG0469	pyruvate kinase activity
SPN033038_RS10805	COG0582	viral genome integration into host DNA
SPN033038_RS10840	COG3689	TIGRFAM TIGR03943 family protein
SPN033038_RS10845	COG0701	Predicted permease
SPN033038_RS10855	COG2183	response to ionizing radiation
SPN033038_RS10875	COG1136	(ABC) transporter
SPN033038_RS10880	COG0577	efflux transmembrane transporter activity
SPN033038_RS10900	COG1982	Orn Lys Arg decarboxylase major
SPN033038_RS10915	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SPN033038_RS10935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPN033038_RS10940	COG0561	phosphatase activity
SPN033038_RS10960	COG0583	DNA-binding transcription factor activity
SPN033038_RS10965	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPN033038_RS10970	COG0564	pseudouridine synthase activity
SPN033038_RS10975	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPN033038_RS10990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPN033038_RS11000	COG0470	DNA polymerase III
SPN033038_RS11045	COG0528	UMP kinase activity
SPN033038_RS11055	COG2996	Protein conserved in bacteria
SPN033038_RS11065	COG1702	phosphate starvation-inducible protein PhoH
SPN033038_RS11080	COG0686	Belongs to the AlaDH PNT family
SPN033038_RS11085	COG0686	Belongs to the AlaDH PNT family
SPN033038_RS11090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPN033038_RS11095	COG1596	polysaccharide export
SPN033038_RS11095	COG1555	photosystem II stabilization
SPN033038_RS11100	COG2333	competence protein COMEC
SPN033038_RS11100	COG0658	competence protein
SPN033038_RS11110	COG1131	(ABC) transporter
SPN033038_RS11140	COG0543	2 iron, 2 sulfur cluster binding
SPN033038_RS11145	COG0167	dihydroorotate dehydrogenase activity
SPN033038_RS11150	COG4193	domain, Protein
SPN033038_RS11150	COG5263	repeat protein
SPN033038_RS11155	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPN033038_RS11165	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPN033038_RS11175	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPN033038_RS11180	COG0237	dephospho-CoA kinase activity
SPN033038_RS11185	COG2814	Major facilitator Superfamily
SPN033038_RS11190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPN033038_RS11200	COG0557	exoribonuclease II activity
SPN033038_RS11210	COG3615	Tellurite resistance protein tehB
SPN033038_RS11210	COG0500	methyltransferase
SPN033038_RS11240	COG4122	O-methyltransferase activity
SPN033038_RS11250	COG2801	Transposase and inactivated derivatives
SPN033038_RS11265	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SPN033038_RS11285	COG0494	nUDIX hydrolase
SPN033038_RS11295	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPN033038_RS11305	COG2176	DNA-directed DNA polymerase activity
SPN033038_RS11310	COG0584	glycerophosphoryl diester phosphodiesterase
SPN033038_RS11330	COG0785	Cytochrome C biogenesis protein
SPN033038_RS11335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPN033038_RS11340	COG0531	amino acid
SPN033038_RS11345	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPN033038_RS11345	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPN033038_RS11385	COG2195	Cleaves the N-terminal amino acid of tripeptides
SPN033038_RS11405	COG0681	Belongs to the peptidase S26 family
SPN033038_RS11415	COG4509	Sortase family
SPN033038_RS11425	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SPN033038_RS11430	COG1970	mechanosensitive ion channel activity
SPN033038_RS11440	COG4708	membrane
SPN033038_RS11460	COG3335	DDE superfamily endonuclease
SPN033038_RS11500	COG1136	(ABC) transporter
SPN033038_RS11500	COG0577	efflux transmembrane transporter activity