locus-tag	class	description
SPN034156_RS00005	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPN034156_RS00015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SPN034156_RS00020	COG1942	4-Oxalocrotonate Tautomerase
SPN034156_RS00025	COG1435	thymidine kinase activity
SPN034156_RS00030	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SPN034156_RS00035	COG2890	protein-(glutamine-N5) methyltransferase activity
SPN034156_RS00060	COG0741	lytic transglycosylase activity
SPN034156_RS00070	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPN034156_RS00090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPN034156_RS00095	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPN034156_RS00145	COG1597	lipid kinase activity
SPN034156_RS00150	COG0366	Alpha amylase catalytic
SPN034156_RS00165	COG1396	sequence-specific DNA binding
SPN034156_RS00170	COG0542	response to heat
SPN034156_RS00175	COG0613	PHP domain protein
SPN034156_RS00200	COG1181	Belongs to the D-alanine--D-alanine ligase family
SPN034156_RS00205	COG0148	phosphopyruvate hydratase activity
SPN034156_RS00210	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPN034156_RS00215	COG3959	Transketolase, thiamine diphosphate binding domain
SPN034156_RS00220	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPN034156_RS00225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SPN034156_RS00235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SPN034156_RS00250	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
SPN034156_RS00250	COG0028	Belongs to the TPP enzyme family
SPN034156_RS00265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPN034156_RS00275	COG4555	ABC transporter
SPN034156_RS00290	COG2723	6-phospho-beta-galactosidase activity
SPN034156_RS00295	COG1396	sequence-specific DNA binding
SPN034156_RS00320	COG0772	Belongs to the SEDS family
SPN034156_RS00325	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SPN034156_RS00340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPN034156_RS00345	COG0358	DNA primase activity
SPN034156_RS00350	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPN034156_RS00355	COG2151	metal-sulfur cluster biosynthetic enzyme
SPN034156_RS00360	COG0438	transferase activity, transferring glycosyl groups
SPN034156_RS00365	COG0438	transferase activity, transferring glycosyl groups
SPN034156_RS00390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPN034156_RS00400	COG4109	DRTGG domain
SPN034156_RS00405	COG0024	Methionine aminopeptidase
SPN034156_RS00420	COG0210	DNA helicase
SPN034156_RS00430	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPN034156_RS00450	COG1104	cysteine desulfurase activity
SPN034156_RS00455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPN034156_RS00465	COG2357	RelA SpoT domain protein
SPN034156_RS00475	COG0564	pseudouridine synthase activity
SPN034156_RS00480	COG0280	phosphate acetyltransferase
SPN034156_RS00520	COG0196	riboflavin kinase activity
SPN034156_RS00525	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPN034156_RS00530	COG1307	EDD domain protein, DegV family
SPN034156_RS00540	COG0488	(ABC) transporter
SPN034156_RS00560	COG1523	belongs to the glycosyl hydrolase 13 family
SPN034156_RS00570	COG1012	belongs to the aldehyde dehydrogenase family
SPN034156_RS00575	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SPN034156_RS00585	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SPN034156_RS00595	COG0560	Phosphoserine phosphatase
SPN034156_RS00600	COG0560	Phosphoserine phosphatase
SPN034156_RS00620	COG0582	viral genome integration into host DNA
SPN034156_RS00645	COG1074	ATP-dependent DNA helicase activity
SPN034156_RS00665	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPN034156_RS00670	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SPN034156_RS00685	COG0095	Lipoate-protein ligase
SPN034156_RS00690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPN034156_RS00695	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPN034156_RS00700	COG0022	dehydrogenase e1 component
SPN034156_RS00705	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPN034156_RS00710	COG0534	Mate efflux family protein
SPN034156_RS00720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPN034156_RS00725	COG1051	belongs to the nudix hydrolase family
SPN034156_RS00740	COG1011	Hydrolase
SPN034156_RS00745	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SPN034156_RS00760	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPN034156_RS00765	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPN034156_RS00770	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPN034156_RS00775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPN034156_RS00805	COG3711	transcriptional antiterminator
SPN034156_RS00810	COG3684	Belongs to the aldolase LacD family
SPN034156_RS00865	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SPN034156_RS00870	COG0497	DNA recombination
SPN034156_RS00875	COG1438	arginine binding
SPN034156_RS00880	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPN034156_RS00915	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SPN034156_RS00935	COG3764	Sortase (surface protein transpeptidase)
SPN034156_RS00940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPN034156_RS00950	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SPN034156_RS00965	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPN034156_RS00970	COG5002	protein histidine kinase activity
SPN034156_RS00975	COG0745	RESPONSE REGULATOR receiver
SPN034156_RS00980	COG1194	a g-specific adenine glycosylase
SPN034156_RS00995	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPN034156_RS01000	COG4684	Psort location CytoplasmicMembrane, score
SPN034156_RS01010	COG1827	regulation of RNA biosynthetic process
SPN034156_RS01040	COG0765	amino acid transport
SPN034156_RS01045	COG1126	abc transporter atp-binding protein
SPN034156_RS01050	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPN034156_RS01055	COG0552	protein localization to endoplasmic reticulum
SPN034156_RS01060	COG0561	phosphatase activity
SPN034156_RS01065	COG0561	phosphatase activity
SPN034156_RS01070	COG1196	nuclear chromosome segregation
SPN034156_RS01095	COG1401	restriction endodeoxyribonuclease activity
SPN034156_RS01110	COG0066	3-isopropylmalate dehydratase activity
SPN034156_RS01140	COG3142	Participates in the control of copper homeostasis
SPN034156_RS01145	COG2832	Protein of unknown function (DUF454)
SPN034156_RS01150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPN034156_RS01160	COG0758	DNA mediated transformation
SPN034156_RS01165	COG4750	Nucleotidyl transferase
SPN034156_RS01180	COG1063	alcohol dehydrogenase
SPN034156_RS01195	COG3475	LICD family
SPN034156_RS01200	COG3475	LICD family
SPN034156_RS01210	COG0505	Belongs to the CarA family
SPN034156_RS01225	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPN034156_RS01240	COG0488	(ABC) transporter
SPN034156_RS01250	COG1704	LemA family
SPN034156_RS01265	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPN034156_RS01280	COG1078	dGTPase activity
SPN034156_RS01300	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPN034156_RS01305	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPN034156_RS01310	COG1605	Chorismate mutase
SPN034156_RS01310	COG0077	Prephenate dehydratase
SPN034156_RS01315	COG0716	FMN binding
SPN034156_RS01320	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPN034156_RS01345	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPN034156_RS01380	COG3335	DDE superfamily endonuclease
SPN034156_RS01410	COG0577	efflux transmembrane transporter activity
SPN034156_RS01410	COG1136	(ABC) transporter
SPN034156_RS01420	COG0515	serine threonine protein kinase
SPN034156_RS01460	COG0402	S-adenosylhomocysteine deaminase activity
SPN034156_RS01470	COG1132	(ABC) transporter
SPN034156_RS01475	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPN034156_RS01475	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPN034156_RS01510	COG1215	transferase activity, transferring glycosyl groups
SPN034156_RS01520	COG3475	LICD family
SPN034156_RS01530	COG0077	Prephenate dehydratase
SPN034156_RS01535	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SPN034156_RS01550	COG0287	Prephenate dehydrogenase
SPN034156_RS01575	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPN034156_RS01585	COG1131	(ABC) transporter
SPN034156_RS01625	COG3842	ATPase activity
SPN034156_RS01640	COG3527	Alpha-acetolactate decarboxylase
SPN034156_RS01645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPN034156_RS01650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN034156_RS01655	COG0704	Plays a role in the regulation of phosphate uptake
SPN034156_RS01660	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPN034156_RS01665	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPN034156_RS01670	COG0581	inorganic phosphate transmembrane transporter activity
SPN034156_RS01675	COG0573	inorganic phosphate transmembrane transporter activity
SPN034156_RS01680	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPN034156_RS01685	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPN034156_RS01685	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPN034156_RS01690	COG0483	inositol monophosphate 1-phosphatase activity
SPN034156_RS01700	COG1393	Belongs to the ArsC family
SPN034156_RS01710	COG0647	UMP catabolic process
SPN034156_RS01720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPN034156_RS01755	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SPN034156_RS01780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPN034156_RS01790	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPN034156_RS01825	COG0826	peptidase U32
SPN034156_RS01850	COG1132	(ABC) transporter
SPN034156_RS01855	COG1132	(ABC) transporter
SPN034156_RS01870	COG1129	ABC transporter
SPN034156_RS01880	COG4372	Transposase
SPN034156_RS01915	COG2188	Transcriptional regulator
SPN034156_RS01925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPN034156_RS01940	COG0561	phosphatase activity
SPN034156_RS01970	COG0492	ferredoxin-NADP+ reductase activity
SPN034156_RS01980	COG1126	abc transporter atp-binding protein
SPN034156_RS01990	COG1393	Belongs to the ArsC family
SPN034156_RS01995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SPN034156_RS02010	COG1272	protein, Hemolysin III
SPN034156_RS02040	COG3976	FMN-binding domain protein
SPN034156_RS02040	COG1053	succinate dehydrogenase
SPN034156_RS02040	COG0431	NADPH-dependent FMN reductase
SPN034156_RS02050	COG0751	glycine-tRNA ligase activity
SPN034156_RS02065	COG0656	L-ascorbic acid biosynthetic process
SPN034156_RS02070	COG0726	polysaccharide deacetylase
SPN034156_RS02090	COG3335	DDE superfamily endonuclease
SPN034156_RS02105	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPN034156_RS02140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPN034156_RS02150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN034156_RS02155	COG1126	abc transporter atp-binding protein
SPN034156_RS02170	COG0628	permease
SPN034156_RS02175	COG2706	6-phosphogluconolactonase activity
SPN034156_RS02190	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SPN034156_RS02245	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPN034156_RS02270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPN034156_RS02275	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SPN034156_RS02280	COG0626	cystathionine gamma-synthase activity
SPN034156_RS02285	COG1132	(ABC) transporter
SPN034156_RS02290	COG1132	(ABC) transporter
SPN034156_RS02300	COG4166	transmembrane transport
SPN034156_RS02305	COG2244	polysaccharide biosynthetic process
SPN034156_RS02310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPN034156_RS02335	COG2827	Endonuclease containing a URI domain
SPN034156_RS02340	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPN034156_RS02345	COG1098	S1 RNA binding domain
SPN034156_RS02355	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPN034156_RS02360	COG0629	single-stranded DNA binding
SPN034156_RS02370	COG0017	Asparaginyl-tRNA synthetase
SPN034156_RS02380	COG0436	Aminotransferase
SPN034156_RS02415	COG0242	peptide deformylase activity
SPN034156_RS02420	COG0625	glutathione transferase activity
SPN034156_RS02430	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPN034156_RS02435	COG0488	(ABC) transporter
SPN034156_RS02440	COG0617	tRNA 3'-terminal CCA addition
SPN034156_RS02450	COG1307	EDD domain protein, DegV family
SPN034156_RS02470	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPN034156_RS02485	COG1481	regulation of sporulation
SPN034156_RS02490	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SPN034156_RS02500	COG0251	oxidation-reduction process
SPN034156_RS02520	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPN034156_RS02540	COG3935	DnaD domain protein
SPN034156_RS02555	COG2226	methyltransferase
SPN034156_RS02565	COG3842	ATPase activity
SPN034156_RS02575	COG1335	isochorismatase
SPN034156_RS02585	COG0513	Belongs to the DEAD box helicase family
SPN034156_RS02590	COG2223	nitrite transmembrane transporter activity
SPN034156_RS02595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPN034156_RS02600	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPN034156_RS02605	COG3442	glutamine amidotransferase
SPN034156_RS02610	COG0006	proline dipeptidase activity
SPN034156_RS02615	COG2801	Transposase and inactivated derivatives
SPN034156_RS02630	COG4720	Psort location CytoplasmicMembrane, score
SPN034156_RS02635	COG0351	phosphomethylpyrimidine kinase
SPN034156_RS02660	COG2824	Alkylphosphonate utilization operon protein PhnA
SPN034156_RS02680	COG0463	Glycosyl transferase, family 2
SPN034156_RS02685	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPN034156_RS02695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPN034156_RS02700	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SPN034156_RS02705	COG2384	SAM-dependent methyltransferase
SPN034156_RS02720	COG2801	Transposase and inactivated derivatives
SPN034156_RS02725	COG2801	Transposase and inactivated derivatives
SPN034156_RS02740	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SPN034156_RS02745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SPN034156_RS02750	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPN034156_RS02750	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
SPN034156_RS02750	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPN034156_RS02755	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPN034156_RS02775	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SPN034156_RS02780	COG0204	Acyl-transferase
SPN034156_RS02795	COG2910	NAD(P)H-binding
SPN034156_RS02820	COG5002	protein histidine kinase activity
SPN034156_RS02825	COG0745	RESPONSE REGULATOR receiver
SPN034156_RS02840	COG1959	2 iron, 2 sulfur cluster binding
SPN034156_RS02890	COG3590	peptidase
SPN034156_RS02910	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPN034156_RS02915	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SPN034156_RS02925	COG1136	(ABC) transporter
SPN034156_RS02925	COG0577	efflux transmembrane transporter activity
SPN034156_RS02970	COG3599	regulation of cell shape
SPN034156_RS02990	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPN034156_RS03010	COG1051	belongs to the nudix hydrolase family
SPN034156_RS03015	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPN034156_RS03030	COG0768	penicillin binding
SPN034156_RS03045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPN034156_RS03060	COG2731	YhcH YjgK YiaL family protein
SPN034156_RS03065	COG0395	ABC-type sugar transport system, permease component
SPN034156_RS03070	COG1175	transmembrane transport
SPN034156_RS03080	COG2190	(PTS) system
SPN034156_RS03080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN034156_RS03080	COG1263	PTS System
SPN034156_RS03090	COG0673	inositol 2-dehydrogenase activity
SPN034156_RS03095	COG4409	exo-alpha-(2->6)-sialidase activity
SPN034156_RS03105	COG1175	transmembrane transport
SPN034156_RS03110	COG1653	transport
SPN034156_RS03130	COG3458	cephalosporin-C deacetylase activity
SPN034156_RS03135	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPN034156_RS03150	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPN034156_RS03155	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPN034156_RS03170	COG1131	(ABC) transporter
SPN034156_RS03200	COG0778	Nitroreductase
SPN034156_RS03205	COG1484	DNA-dependent DNA replication
SPN034156_RS03220	COG1725	Transcriptional regulator
SPN034156_RS03225	COG1131	(ABC) transporter
SPN034156_RS03235	COG1668	transmembrane transport
SPN034156_RS03240	COG4152	abc transporter atp-binding protein
SPN034156_RS03255	COG1940	carbohydrate kinase activity
SPN034156_RS03260	COG2190	(PTS) system
SPN034156_RS03260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN034156_RS03260	COG1263	PTS System
SPN034156_RS03270	COG1621	beta-fructofuranosidase activity
SPN034156_RS03275	COG1609	Transcriptional regulator
SPN034156_RS03285	COG3425	synthase
SPN034156_RS03315	COG2815	serine threonine protein kinase
SPN034156_RS03315	COG0515	serine threonine protein kinase
SPN034156_RS03320	COG0631	protein serine/threonine phosphatase activity
SPN034156_RS03325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPN034156_RS03325	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPN034156_RS03335	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPN034156_RS03345	COG0194	GDP metabolic process
SPN034156_RS03360	COG1323	Belongs to the UPF0348 family
SPN034156_RS03365	COG2226	methyltransferase
SPN034156_RS03370	COG0799	negative regulation of ribosome biogenesis
SPN034156_RS03380	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPN034156_RS03385	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SPN034156_RS03390	COG1534	Rna-binding protein
SPN034156_RS03395	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPN034156_RS03410	COG0668	transmembrane transport
SPN034156_RS03435	COG3118	belongs to the thioredoxin family
SPN034156_RS03440	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SPN034156_RS03450	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPN034156_RS03465	COG1164	Oligoendopeptidase f
SPN034156_RS03470	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPN034156_RS03475	COG2264	protein methyltransferase activity
SPN034156_RS03480	COG1051	belongs to the nudix hydrolase family
SPN034156_RS03515	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPN034156_RS03525	COG1621	beta-fructofuranosidase activity
SPN034156_RS03530	COG1653	transport
SPN034156_RS03535	COG0395	ABC-type sugar transport system, permease component
SPN034156_RS03540	COG4209	transmembrane transport
SPN034156_RS03550	COG3711	transcriptional antiterminator
SPN034156_RS03575	COG3237	CsbD-like
SPN034156_RS03590	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SPN034156_RS03615	COG0135	phosphoribosylanthranilate isomerase activity
SPN034156_RS03630	COG0512	Glutamine amidotransferase of anthranilate synthase
SPN034156_RS03635	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPN034156_RS03660	COG1285	pathogenesis
SPN034156_RS03665	COG1178	ABC-type Fe3 transport system permease component
SPN034156_RS03690	COG5434	Belongs to the glycosyl hydrolase 28 family
SPN034156_RS03705	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SPN034156_RS03710	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPN034156_RS03715	COG1132	(ABC) transporter
SPN034156_RS03720	COG1132	(ABC) transporter
SPN034156_RS03745	COG0708	Exodeoxyribonuclease III
SPN034156_RS03765	COG2233	PERMEase
SPN034156_RS03790	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPN034156_RS03795	COG1609	Transcriptional regulator
SPN034156_RS03800	COG1063	alcohol dehydrogenase
SPN034156_RS03805	COG0789	Transcriptional regulator
SPN034156_RS03810	COG1230	cation diffusion facilitator family transporter
SPN034156_RS03820	COG3201	nicotinamide mononucleotide transporter
SPN034156_RS03825	COG1174	glycine betaine transport
SPN034156_RS03850	COG1363	Peptidase, m42
SPN034156_RS03855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPN034156_RS03865	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPN034156_RS03870	COG4605	iron ion homeostasis
SPN034156_RS03875	COG4604	ABC transporter, ATP-binding protein
SPN034156_RS03880	COG4607	ABC-type enterochelin transport system periplasmic component
SPN034156_RS03890	COG1187	pseudouridine synthase activity
SPN034156_RS03910	COG0517	IMP dehydrogenase activity
SPN034156_RS03920	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SPN034156_RS03940	COG0366	Alpha amylase catalytic
SPN034156_RS03945	COG1263	PTS System
SPN034156_RS03945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN034156_RS03950	COG2188	Transcriptional regulator
SPN034156_RS03970	COG4608	Belongs to the ABC transporter superfamily
SPN034156_RS03975	COG0444	Belongs to the ABC transporter superfamily
SPN034156_RS03980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPN034156_RS03985	COG0601	transmembrane transport
SPN034156_RS03990	COG4166	transmembrane transport
SPN034156_RS04005	COG0395	ABC-type sugar transport system, permease component
SPN034156_RS04010	COG1175	transmembrane transport
SPN034156_RS04015	COG1653	transport
SPN034156_RS04020	COG3345	alpha-galactosidase
SPN034156_RS04025	COG2207	Transcriptional regulator
SPN034156_RS04030	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPN034156_RS04030	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPN034156_RS04150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPN034156_RS04200	COG4221	oxidoreductase activity
SPN034156_RS04205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPN034156_RS04210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPN034156_RS04285	COG3842	ATPase activity
SPN034156_RS04290	COG1178	ABC-type Fe3 transport system permease component
SPN034156_RS04295	COG1285	pathogenesis
SPN034156_RS04355	COG5263	repeat protein
SPN034156_RS04355	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPN034156_RS04375	COG1316	TRANSCRIPTIONal
SPN034156_RS04385	COG0802	atpase or kinase
SPN034156_RS04410	COG1136	(ABC) transporter
SPN034156_RS04440	COG1253	flavin adenine dinucleotide binding
SPN034156_RS04455	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPN034156_RS04465	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPN034156_RS04475	COG0742	ribosomal rna small subunit methyltransferase
SPN034156_RS04495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPN034156_RS04500	COG1254	Belongs to the acylphosphatase family
SPN034156_RS04510	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPN034156_RS04520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPN034156_RS04535	COG1564	THIamine pyrophosphokinase
SPN034156_RS04545	COG1162	GTPase activity
SPN034156_RS04550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SPN034156_RS04575	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SPN034156_RS04580	COG0084	hydrolase, TatD family'
SPN034156_RS04600	COG0436	Aminotransferase
SPN034156_RS04610	COG0589	response to stress
SPN034156_RS04615	COG0561	phosphatase activity
SPN034156_RS04620	COG0252	asparaginase activity
SPN034156_RS04630	COG1609	Transcriptional regulator
SPN034156_RS04635	COG2197	response regulator
SPN034156_RS04640	COG4585	Histidine kinase
SPN034156_RS04645	COG0842	Transport permease protein
SPN034156_RS04650	COG1131	(ABC) transporter
SPN034156_RS04755	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPN034156_RS04760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPN034156_RS04795	COG0157	Belongs to the NadC ModD family
SPN034156_RS04805	COG4133	protoheme IX ABC transporter activity
SPN034156_RS04810	COG2188	Transcriptional regulator
SPN034156_RS04815	COG2723	6-phospho-beta-galactosidase activity
SPN034156_RS04820	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN034156_RS04830	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPN034156_RS04835	COG1012	belongs to the aldehyde dehydrogenase family
SPN034156_RS04835	COG1454	alcohol dehydrogenase
SPN034156_RS04845	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPN034156_RS04855	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SPN034156_RS04875	COG3623	hexulose-6-phosphate isomerase
SPN034156_RS04885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPN034156_RS04895	COG3037	sugar-specific permease SgaT UlaA
SPN034156_RS04905	COG1847	R3H domain protein
SPN034156_RS04910	COG0706	membrane insertase activity
SPN034156_RS04960	COG4537	Required for transformation and DNA binding
SPN034156_RS04965	COG1459	type II secretion system
SPN034156_RS04970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPN034156_RS04980	COG1063	alcohol dehydrogenase
SPN034156_RS05005	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SPN034156_RS05010	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SPN034156_RS05015	COG3759	membrane
SPN034156_RS05030	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SPN034156_RS05030	COG0131	Imidazoleglycerol-phosphate dehydratase
SPN034156_RS05035	COG0534	Mate efflux family protein
SPN034156_RS05150	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPN034156_RS05155	COG1132	(ABC) transporter
SPN034156_RS05165	COG1132	(ABC) transporter
SPN034156_RS05175	COG1438	arginine binding
SPN034156_RS05195	COG0745	RESPONSE REGULATOR receiver
SPN034156_RS05200	COG5002	protein histidine kinase activity
SPN034156_RS05205	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPN034156_RS05210	COG0573	inorganic phosphate transmembrane transporter activity
SPN034156_RS05220	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPN034156_RS05225	COG0704	Plays a role in the regulation of phosphate uptake
SPN034156_RS05245	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPN034156_RS05255	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPN034156_RS05270	COG0697	spore germination
SPN034156_RS05275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPN034156_RS05275	COG4499	WXG100 protein secretion system (Wss), protein YukC
SPN034156_RS05285	COG2217	Heavy metal translocating P-type atpase
SPN034156_RS05295	COG2226	methyltransferase
SPN034156_RS05320	COG0058	SHG alpha-glucan phosphorylase activity
SPN034156_RS05325	COG1640	4-alpha-glucanotransferase
SPN034156_RS05330	COG2182	Extracellular solute-binding protein
SPN034156_RS05335	COG1175	transmembrane transport
SPN034156_RS05340	COG3833	ABC-type maltose transport systems, permease component
SPN034156_RS05345	COG5521	maltodextrose utilization protein MalA
SPN034156_RS05350	COG1609	Transcriptional regulator
SPN034156_RS05355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPN034156_RS05390	COG1476	TRANSCRIPTIONal
SPN034156_RS05420	COG2151	metal-sulfur cluster biosynthetic enzyme
SPN034156_RS05430	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPN034156_RS05435	COG3959	Transketolase, thiamine diphosphate binding domain
SPN034156_RS05450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPN034156_RS05470	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPN034156_RS05485	COG0383	alpha-mannosidase activity
SPN034156_RS05495	COG3537	Alpha-1,2-mannosidase
SPN034156_RS05515	COG0549	Belongs to the carbamate kinase family
SPN034156_RS05520	COG1288	antiporter activity
SPN034156_RS05525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPN034156_RS05540	COG3583	domain protein
SPN034156_RS05540	COG3064	Membrane
SPN034156_RS05540	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPN034156_RS05550	COG1454	alcohol dehydrogenase
SPN034156_RS05555	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
SPN034156_RS05570	COG3716	PTS system mannose fructose sorbose family IID component
SPN034156_RS05580	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN034156_RS05610	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPN034156_RS05610	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPN034156_RS05615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPN034156_RS05620	COG1121	(ABC) transporter
SPN034156_RS05625	COG1846	Transcriptional regulator
SPN034156_RS05630	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPN034156_RS05640	COG1696	Membrane protein involved in D-alanine export
SPN034156_RS05655	COG2211	Major facilitator Superfamily
SPN034156_RS05660	COG3344	reverse transcriptase
SPN034156_RS05675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPN034156_RS05680	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SPN034156_RS05700	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPN034156_RS05705	COG0366	Alpha amylase catalytic
SPN034156_RS05715	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPN034156_RS05720	COG5002	protein histidine kinase activity
SPN034156_RS05725	COG0745	RESPONSE REGULATOR receiver
SPN034156_RS05730	COG0542	response to heat
SPN034156_RS05735	COG4463	regulation of RNA biosynthetic process
SPN034156_RS05740	COG1116	anion transmembrane transporter activity
SPN034156_RS05745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SPN034156_RS05750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SPN034156_RS05770	COG0305	Participates in initiation and elongation during chromosome replication
SPN034156_RS05790	COG1040	competence protein
SPN034156_RS05795	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPN034156_RS05800	COG1739	Uncharacterized protein family UPF0029
SPN034156_RS05815	COG3335	DDE superfamily endonuclease
SPN034156_RS05835	COG3942	CHAP domain
SPN034156_RS05845	COG1792	Involved in formation and maintenance of cell shape
SPN034156_RS05850	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPN034156_RS05855	COG1122	ATPase activity
SPN034156_RS05860	COG1122	ATPase activity
SPN034156_RS05865	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPN034156_RS05875	COG0612	Peptidase, M16
SPN034156_RS05880	COG0612	Peptidase, M16
SPN034156_RS05885	COG2501	S4 domain
SPN034156_RS05895	COG0517	IMP dehydrogenase activity
SPN034156_RS05895	COG0516	GMP reductase activity
SPN034156_RS05900	COG0180	Tryptophanyl-tRNA synthetase
SPN034156_RS05905	COG0488	(ABC) transporter
SPN034156_RS05915	COG1511	domain protein
SPN034156_RS05925	COG1511	domain protein
SPN034156_RS05970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPN034156_RS05975	COG1475	DNA binding
SPN034156_RS05985	COG0592	DNA-directed DNA polymerase activity
SPN034156_RS05995	COG0012	GTP binding
SPN034156_RS06005	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPN034156_RS06010	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPN034156_RS06035	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SPN034156_RS06040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPN034156_RS06195	COG0629	single-stranded DNA binding
SPN034156_RS06330	COG5263	repeat protein
SPN034156_RS06330	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPN034156_RS06350	COG0756	dUTP diphosphatase activity
SPN034156_RS06360	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SPN034156_RS06380	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPN034156_RS06405	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPN034156_RS06405	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPN034156_RS06410	COG1832	CoA-binding protein
SPN034156_RS06420	COG2855	membrane
SPN034156_RS06425	COG0436	Aminotransferase
SPN034156_RS06460	COG2274	protein secretion by the type I secretion system
SPN034156_RS06465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPN034156_RS06475	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPN034156_RS06480	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SPN034156_RS06490	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPN034156_RS06505	COG0151	Belongs to the GarS family
SPN034156_RS06510	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPN034156_RS06525	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPN034156_RS06530	COG3583	domain protein
SPN034156_RS06530	COG3064	Membrane
SPN034156_RS06530	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPN034156_RS06545	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN034156_RS06550	COG3715	PTS system
SPN034156_RS06555	COG3716	PTS system mannose fructose sorbose family IID component
SPN034156_RS06565	COG2222	sugar isomerase
SPN034156_RS06575	COG2514	catechol 2,3-dioxygenase activity
SPN034156_RS06580	COG1937	Protein conserved in bacteria
SPN034156_RS06605	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPN034156_RS06610	COG0569	domain protein
SPN034156_RS06640	COG5002	protein histidine kinase activity
SPN034156_RS06665	COG4209	transmembrane transport
SPN034156_RS06670	COG0395	ABC-type sugar transport system, permease component
SPN034156_RS06675	COG1653	transport
SPN034156_RS06705	COG1695	Transcriptional regulator
SPN034156_RS06730	COG0546	phosphoglycolate phosphatase activity
SPN034156_RS06735	COG1760	l-serine dehydratase
SPN034156_RS06740	COG1760	l-serine dehydratase
SPN034156_RS06770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN034156_RS06855	COG0494	nUDIX hydrolase
SPN034156_RS06860	COG0445	tRNA wobble uridine modification
SPN034156_RS06895	COG1214	PFAM Peptidase M22, glycoprotease
SPN034156_RS06925	COG0438	transferase activity, transferring glycosyl groups
SPN034156_RS06960	COG1396	sequence-specific DNA binding
SPN034156_RS06995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN034156_RS07000	COG1464	Belongs to the NlpA lipoprotein family
SPN034156_RS07005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPN034156_RS07010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPN034156_RS07030	COG2972	Histidine kinase
SPN034156_RS07035	COG4753	response regulator
SPN034156_RS07035	COG2207	Transcriptional regulator
SPN034156_RS07045	COG1780	Probably involved in ribonucleotide reductase function
SPN034156_RS07075	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPN034156_RS07075	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPN034156_RS07095	COG2818	Glycosylase
SPN034156_RS07120	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPN034156_RS07125	COG0006	proline dipeptidase activity
SPN034156_RS07135	COG1393	Belongs to the ArsC family
SPN034156_RS07160	COG0285	dihydrofolate synthase activity
SPN034156_RS07170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPN034156_RS07235	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPN034156_RS07260	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SPN034156_RS07300	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SPN034156_RS07315	COG0201	protein transport
SPN034156_RS07325	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SPN034156_RS07330	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SPN034156_RS07340	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SPN034156_RS07345	COG0202	RNA polymerase activity
SPN034156_RS07355	COG3830	Belongs to the UPF0237 family
SPN034156_RS07375	COG1178	ABC-type Fe3 transport system permease component
SPN034156_RS07380	COG3842	ATPase activity
SPN034156_RS07400	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPN034156_RS07405	COG1349	DNA-binding transcription factor activity
SPN034156_RS07415	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPN034156_RS07420	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN034156_RS07425	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN034156_RS07430	COG1882	Formate acetyltransferase
SPN034156_RS07480	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPN034156_RS07485	COG4589	Belongs to the CDS family
SPN034156_RS07490	COG0750	zinc metalloprotease
SPN034156_RS07500	COG2723	6-phospho-beta-galactosidase activity
SPN034156_RS07505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPN034156_RS07535	COG2176	DNA-directed DNA polymerase activity
SPN034156_RS07555	COG2309	aminopeptidase activity
SPN034156_RS07560	COG2261	transglycosylase associated protein
SPN034156_RS07565	COG1187	pseudouridine synthase activity
SPN034156_RS07575	COG3579	cysteine-type endopeptidase activity
SPN034156_RS07580	COG3716	PTS system mannose fructose sorbose family IID component
SPN034156_RS07585	COG3715	PTS system
SPN034156_RS07595	COG1064	alcohol dehydrogenase
SPN034156_RS07600	COG0561	phosphatase activity
SPN034156_RS07605	COG2252	PERMEase
SPN034156_RS07615	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SPN034156_RS07620	COG0285	dihydrofolate synthase activity
SPN034156_RS07625	COG0302	gtp cyclohydrolase
SPN034156_RS07630	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SPN034156_RS07630	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPN034156_RS07640	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPN034156_RS07655	COG2723	6-phospho-beta-galactosidase activity
SPN034156_RS07670	COG3711	transcriptional antiterminator
SPN034156_RS07670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPN034156_RS07685	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN034156_RS07685	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN034156_RS07700	COG0386	Belongs to the glutathione peroxidase family
SPN034156_RS07715	COG0800	Aldolase
SPN034156_RS07730	COG1028	Short-chain dehydrogenase reductase Sdr
SPN034156_RS07740	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SPN034156_RS07745	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN034156_RS07750	COG3715	PTS system
SPN034156_RS07755	COG3716	PTS system mannose fructose sorbose family IID component
SPN034156_RS07770	COG1609	Transcriptional regulator
SPN034156_RS07800	COG4839	cell division protein FtsL
SPN034156_RS07805	COG0768	penicillin binding
SPN034156_RS07830	COG0366	Alpha amylase catalytic
SPN034156_RS07835	COG4166	transmembrane transport
SPN034156_RS07890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPN034156_RS07895	COG4166	transmembrane transport
SPN034156_RS07900	COG0366	Alpha amylase catalytic
SPN034156_RS07905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPN034156_RS07930	COG0116	Belongs to the methyltransferase superfamily
SPN034156_RS07940	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SPN034156_RS07945	COG0745	RESPONSE REGULATOR receiver
SPN034156_RS08000	COG4585	Histidine kinase
SPN034156_RS08005	COG2197	response regulator
SPN034156_RS08030	COG0582	viral genome integration into host DNA
SPN034156_RS08040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPN034156_RS08045	COG0681	Belongs to the peptidase S26 family
SPN034156_RS08070	COG1115	amino acid carrier protein
SPN034156_RS08095	COG0527	aspartate kinase activity
SPN034156_RS08100	COG1024	Enoyl-CoA hydratase
SPN034156_RS08105	COG1846	Transcriptional regulator
SPN034156_RS08115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPN034156_RS08125	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPN034156_RS08130	COG1028	Short-chain dehydrogenase reductase Sdr
SPN034156_RS08135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPN034156_RS08150	COG0439	Biotin carboxylase
SPN034156_RS08155	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPN034156_RS08215	COG1442	glycosyl transferase family 8
SPN034156_RS08220	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SPN034156_RS08230	COG1461	Dihydroxyacetone kinase
SPN034156_RS08235	COG0028	Belongs to the TPP enzyme family
SPN034156_RS08240	COG0440	acetolactate synthase activity
SPN034156_RS08260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SPN034156_RS08275	COG0765	amino acid transport
SPN034156_RS08305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPN034156_RS08310	COG1882	Formate acetyltransferase
SPN034156_RS08340	COG1846	Transcriptional regulator
SPN034156_RS08340	COG1940	carbohydrate kinase activity
SPN034156_RS08345	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN034156_RS08355	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPN034156_RS08360	COG2723	6-phospho-beta-galactosidase activity
SPN034156_RS08365	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN034156_RS08365	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN034156_RS08370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPN034156_RS08375	COG0569	domain protein
SPN034156_RS08395	COG1122	ATPase activity
SPN034156_RS08410	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPN034156_RS08415	COG0671	phosphoesterase, PA-phosphatase related
SPN034156_RS08425	COG1247	-acetyltransferase
SPN034156_RS08440	COG0504	CTP synthase activity
SPN034156_RS08445	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPN034156_RS08465	COG0789	Transcriptional regulator
SPN034156_RS08470	COG0174	glutamine synthetase
SPN034156_RS08485	COG4974	Belongs to the 'phage' integrase family
SPN034156_RS08495	COG0732	type I restriction modification DNA specificity domain
SPN034156_RS08525	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SPN034156_RS08540	COG0484	heat shock protein binding
SPN034156_RS08555	COG0537	adenosine 5'-monophosphoramidase activity
SPN034156_RS08560	COG1131	(ABC) transporter
SPN034156_RS08585	COG3290	protein histidine kinase activity
SPN034156_RS08595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPN034156_RS08600	COG2274	protein secretion by the type I secretion system
SPN034156_RS08605	COG2274	protein secretion by the type I secretion system
SPN034156_RS08610	COG2274	protein secretion by the type I secretion system
SPN034156_RS08630	COG1266	CAAX protease self-immunity
SPN034156_RS08650	COG0195	Participates in both transcription termination and antitermination
SPN034156_RS08655	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPN034156_RS08720	COG0519	Catalyzes the synthesis of GMP from XMP
SPN034156_RS08730	COG0525	valine-tRNA ligase activity
SPN034156_RS08745	COG2801	Transposase and inactivated derivatives
SPN034156_RS08750	COG2801	Transposase and inactivated derivatives
SPN034156_RS08770	COG3711	transcriptional antiterminator
SPN034156_RS08775	COG2190	(PTS) system
SPN034156_RS08775	COG1263	PTS System
SPN034156_RS08775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN034156_RS08795	COG0456	acetyltransferase
SPN034156_RS08800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPN034156_RS08800	COG0072	phenylalanine-tRNA ligase activity
SPN034156_RS08820	COG3620	sequence-specific DNA binding
SPN034156_RS08825	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SPN034156_RS08840	COG1045	serine acetyltransferase
SPN034156_RS08850	COG0215	cysteine-tRNA ligase activity
SPN034156_RS08855	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPN034156_RS08875	COG0577	efflux transmembrane transporter activity
SPN034156_RS08880	COG1136	(ABC) transporter
SPN034156_RS08885	COG0577	efflux transmembrane transporter activity
SPN034156_RS08890	COG0745	RESPONSE REGULATOR receiver
SPN034156_RS08895	COG5002	protein histidine kinase activity
SPN034156_RS08900	COG0191	fructose-bisphosphate aldolase activity
SPN034156_RS08910	COG0765	amino acid transport
SPN034156_RS08915	COG0765	amino acid transport
SPN034156_RS08920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN034156_RS08930	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPN034156_RS08930	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPN034156_RS08960	COG0322	excinuclease ABC activity
SPN034156_RS08970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN034156_RS08985	COG1573	uracil-dna glycosylase
SPN034156_RS08995	COG1114	Component of the transport system for branched-chain amino acids
SPN034156_RS09000	COG1363	Peptidase, m42
SPN034156_RS09045	COG4555	ABC transporter
SPN034156_RS09080	COG1404	Belongs to the peptidase S8 family
SPN034156_RS09095	COG3775	system Galactitol-specific IIC component
SPN034156_RS09105	COG3250	beta-galactosidase activity
SPN034156_RS09125	COG1242	4 iron, 4 sulfur cluster binding
SPN034156_RS09130	COG1242	4 iron, 4 sulfur cluster binding
SPN034156_RS09135	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPN034156_RS09155	COG0785	Cytochrome C biogenesis protein
SPN034156_RS09160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPN034156_RS09165	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPN034156_RS09165	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPN034156_RS09170	COG4753	response regulator
SPN034156_RS09170	COG2207	Transcriptional regulator
SPN034156_RS09175	COG2972	Histidine kinase
SPN034156_RS09185	COG3064	Membrane
SPN034156_RS09190	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPN034156_RS09205	COG1940	carbohydrate kinase activity
SPN034156_RS09220	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SPN034156_RS09225	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPN034156_RS09230	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPN034156_RS09240	COG0300	oxidoreductase activity
SPN034156_RS09255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPN034156_RS09265	COG1187	pseudouridine synthase activity
SPN034156_RS09270	COG1217	gtp-binding protein TYPA
SPN034156_RS09290	COG1136	(ABC) transporter
SPN034156_RS09305	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SPN034156_RS09315	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SPN034156_RS09340	COG1131	(ABC) transporter
SPN034156_RS09345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN034156_RS09350	COG1126	abc transporter atp-binding protein
SPN034156_RS09355	COG1129	ABC transporter
SPN034156_RS09360	COG4215	(ABC) transporter
SPN034156_RS09365	COG4597	amino acid ABC transporter
SPN034156_RS09370	COG1304	FMN binding
SPN034156_RS09380	COG1304	FMN binding
SPN034156_RS09395	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SPN034156_RS09400	COG0352	thiamine-phosphate diphosphorylase activity
SPN034156_RS09410	COG4172	Belongs to the ABC transporter superfamily
SPN034156_RS09420	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SPN034156_RS09435	COG0352	thiamine-phosphate diphosphorylase activity
SPN034156_RS09455	COG2217	Heavy metal translocating P-type atpase
SPN034156_RS09460	COG0028	Belongs to the TPP enzyme family
SPN034156_RS09480	COG2723	6-phospho-beta-galactosidase activity
SPN034156_RS09485	COG1482	cell wall glycoprotein biosynthetic process
SPN034156_RS09490	COG0733	neurotransmitter:sodium symporter activity
SPN034156_RS09500	COG0789	Transcriptional regulator
SPN034156_RS09510	COG2081	HI0933 family
SPN034156_RS09515	COG1307	EDD domain protein, DegV family
SPN034156_RS09525	COG2131	deaminase
SPN034156_RS09530	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SPN034156_RS09570	COG0517	IMP dehydrogenase activity
SPN034156_RS09570	COG0617	tRNA 3'-terminal CCA addition
SPN034156_RS09570	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPN034156_RS09575	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SPN034156_RS09580	COG2884	Cell division ATP-binding protein ftsE
SPN034156_RS09585	COG2177	Part of the ABC transporter FtsEX involved in
SPN034156_RS09590	COG1263	PTS System
SPN034156_RS09590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN034156_RS09590	COG2190	(PTS) system
SPN034156_RS09600	COG0513	Belongs to the DEAD box helicase family
SPN034156_RS09610	COG0167	dihydroorotate dehydrogenase activity
SPN034156_RS09620	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SPN034156_RS09625	COG4470	Protein conserved in bacteria
SPN034156_RS09640	COG0488	(ABC) transporter
SPN034156_RS09645	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SPN034156_RS09665	COG1837	Belongs to the UPF0109 family
SPN034156_RS09685	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPN034156_RS09685	COG1328	CTP reductase activity
SPN034156_RS09695	COG4443	Transcriptional Coactivator p15 (PC4)
SPN034156_RS09705	COG1268	BioY protein
SPN034156_RS09710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPN034156_RS09715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPN034156_RS09720	COG1136	(ABC) transporter
SPN034156_RS09725	COG0577	efflux transmembrane transporter activity
SPN034156_RS09730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPN034156_RS09730	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPN034156_RS09750	COG4989	oxidoreductase activity
SPN034156_RS09760	COG1028	Short-chain dehydrogenase reductase Sdr
SPN034156_RS09790	COG0745	RESPONSE REGULATOR receiver
SPN034156_RS09795	COG5002	protein histidine kinase activity
SPN034156_RS09815	COG0772	Belongs to the SEDS family
SPN034156_RS09820	COG0693	protein deglycase activity
SPN034156_RS09830	COG0187	DNA topoisomerase II activity
SPN034156_RS09850	COG0494	nUDIX hydrolase
SPN034156_RS09865	COG0542	response to heat
SPN034156_RS09870	COG4703	Protein of unknown function (DUF1797)
SPN034156_RS09875	COG0765	amino acid transport
SPN034156_RS09880	COG1126	abc transporter atp-binding protein
SPN034156_RS09885	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPN034156_RS09890	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SPN034156_RS09910	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SPN034156_RS09955	COG2813	Specifically methylates the guanine in position
SPN034156_RS09960	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SPN034156_RS09970	COG0295	cytidine deaminase activity
SPN034156_RS09975	COG1744	ABC transporter substrate-binding protein PnrA-like
SPN034156_RS09980	COG3845	ABC transporter
SPN034156_RS09985	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPN034156_RS09990	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPN034156_RS10005	COG2801	Transposase and inactivated derivatives
SPN034156_RS10010	COG2801	Transposase and inactivated derivatives
SPN034156_RS10025	COG0187	DNA topoisomerase II activity
SPN034156_RS10035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPN034156_RS10040	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPN034156_RS10045	COG4166	transmembrane transport
SPN034156_RS10080	COG0539	negative regulation of cytoplasmic translation
SPN034156_RS10100	COG1956	GAF domain-containing protein
SPN034156_RS10105	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPN034156_RS10120	COG0719	Fe-S assembly protein
SPN034156_RS10125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPN034156_RS10135	COG0719	Fe-S assembly protein
SPN034156_RS10145	COG1686	Belongs to the peptidase S11 family
SPN034156_RS10150	COG0628	permease
SPN034156_RS10160	COG1349	DNA-binding transcription factor activity
SPN034156_RS10165	COG1105	Belongs to the carbohydrate kinase PfkB family
SPN034156_RS10170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPN034156_RS10170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPN034156_RS10170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPN034156_RS10175	COG1674	ftsk spoiiie
SPN034156_RS10175	COG0697	spore germination
SPN034156_RS10185	COG1104	cysteine desulfurase activity
SPN034156_RS10255	COG1438	arginine binding
SPN034156_RS10275	COG0469	pyruvate kinase activity
SPN034156_RS10310	COG3689	TIGRFAM TIGR03943 family protein
SPN034156_RS10315	COG0701	Predicted permease
SPN034156_RS10325	COG2183	response to ionizing radiation
SPN034156_RS10345	COG1136	(ABC) transporter
SPN034156_RS10350	COG0577	efflux transmembrane transporter activity
SPN034156_RS10370	COG1982	Orn Lys Arg decarboxylase major
SPN034156_RS10385	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SPN034156_RS10405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPN034156_RS10410	COG0561	phosphatase activity
SPN034156_RS10430	COG0583	DNA-binding transcription factor activity
SPN034156_RS10435	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPN034156_RS10440	COG0564	pseudouridine synthase activity
SPN034156_RS10445	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPN034156_RS10460	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPN034156_RS10470	COG0470	DNA polymerase III
SPN034156_RS10490	COG0528	UMP kinase activity
SPN034156_RS10510	COG1702	phosphate starvation-inducible protein PhoH
SPN034156_RS10525	COG0686	Belongs to the AlaDH PNT family
SPN034156_RS10530	COG0686	Belongs to the AlaDH PNT family
SPN034156_RS10535	COG0686	Belongs to the AlaDH PNT family
SPN034156_RS10540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPN034156_RS10545	COG1555	photosystem II stabilization
SPN034156_RS10545	COG1596	polysaccharide export
SPN034156_RS10550	COG2333	competence protein COMEC
SPN034156_RS10550	COG0658	competence protein
SPN034156_RS10560	COG1131	(ABC) transporter
SPN034156_RS10590	COG0543	2 iron, 2 sulfur cluster binding
SPN034156_RS10595	COG0167	dihydroorotate dehydrogenase activity
SPN034156_RS10600	COG4193	domain, Protein
SPN034156_RS10600	COG5263	repeat protein
SPN034156_RS10605	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPN034156_RS10615	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPN034156_RS10625	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPN034156_RS10630	COG0237	dephospho-CoA kinase activity
SPN034156_RS10635	COG2814	Major facilitator Superfamily
SPN034156_RS10640	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPN034156_RS10650	COG0557	exoribonuclease II activity
SPN034156_RS10660	COG0500	methyltransferase
SPN034156_RS10660	COG3615	Tellurite resistance protein tehB
SPN034156_RS10675	COG4122	O-methyltransferase activity
SPN034156_RS10685	COG2801	Transposase and inactivated derivatives
SPN034156_RS10700	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SPN034156_RS10720	COG0494	nUDIX hydrolase
SPN034156_RS10730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPN034156_RS10740	COG2176	DNA-directed DNA polymerase activity
SPN034156_RS10745	COG0584	glycerophosphoryl diester phosphodiesterase
SPN034156_RS10765	COG0785	Cytochrome C biogenesis protein
SPN034156_RS10770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPN034156_RS10775	COG0531	amino acid
SPN034156_RS10780	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPN034156_RS10780	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPN034156_RS10825	COG1970	mechanosensitive ion channel activity
SPN034156_RS10835	COG4708	membrane