locus-tag	class	description
SPN994039_RS00010	COG0592	DNA-directed DNA polymerase activity
SPN994039_RS00020	COG0012	GTP binding
SPN994039_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPN994039_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPN994039_RS00060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SPN994039_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPN994039_RS00235	COG0582	viral genome integration into host DNA
SPN994039_RS00350	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPN994039_RS00350	COG5263	repeat protein
SPN994039_RS00370	COG0756	dUTP diphosphatase activity
SPN994039_RS00380	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SPN994039_RS00400	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPN994039_RS00425	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPN994039_RS00425	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPN994039_RS00430	COG1832	CoA-binding protein
SPN994039_RS00440	COG2855	membrane
SPN994039_RS00445	COG0436	Aminotransferase
SPN994039_RS00480	COG2274	protein secretion by the type I secretion system
SPN994039_RS00485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPN994039_RS00495	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPN994039_RS00500	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SPN994039_RS00510	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPN994039_RS00525	COG0151	Belongs to the GarS family
SPN994039_RS00530	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPN994039_RS00545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPN994039_RS00550	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPN994039_RS00550	COG3064	Membrane
SPN994039_RS00550	COG3583	domain protein
SPN994039_RS00565	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN994039_RS00570	COG3715	PTS system
SPN994039_RS00575	COG3716	PTS system mannose fructose sorbose family IID component
SPN994039_RS00585	COG2222	sugar isomerase
SPN994039_RS00595	COG2514	catechol 2,3-dioxygenase activity
SPN994039_RS00600	COG1937	Protein conserved in bacteria
SPN994039_RS00625	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPN994039_RS00630	COG0569	domain protein
SPN994039_RS00660	COG5002	protein histidine kinase activity
SPN994039_RS00680	COG4209	transmembrane transport
SPN994039_RS00685	COG0395	ABC-type sugar transport system, permease component
SPN994039_RS00690	COG1653	transport
SPN994039_RS00720	COG1695	Transcriptional regulator
SPN994039_RS00745	COG0546	phosphoglycolate phosphatase activity
SPN994039_RS00750	COG1760	l-serine dehydratase
SPN994039_RS00755	COG1760	l-serine dehydratase
SPN994039_RS00770	COG2274	protein secretion by the type I secretion system
SPN994039_RS00860	COG0445	tRNA wobble uridine modification
SPN994039_RS00890	COG1214	PFAM Peptidase M22, glycoprotease
SPN994039_RS00900	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SPN994039_RS00935	COG0438	transferase activity, transferring glycosyl groups
SPN994039_RS01005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN994039_RS01010	COG1464	Belongs to the NlpA lipoprotein family
SPN994039_RS01015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPN994039_RS01020	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPN994039_RS01040	COG2972	Histidine kinase
SPN994039_RS01045	COG2207	Transcriptional regulator
SPN994039_RS01045	COG4753	response regulator
SPN994039_RS01055	COG1780	Probably involved in ribonucleotide reductase function
SPN994039_RS01085	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPN994039_RS01085	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPN994039_RS01105	COG2818	Glycosylase
SPN994039_RS01130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPN994039_RS01135	COG0006	proline dipeptidase activity
SPN994039_RS01140	COG1393	Belongs to the ArsC family
SPN994039_RS01165	COG0285	dihydrofolate synthase activity
SPN994039_RS01175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPN994039_RS01240	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPN994039_RS01265	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SPN994039_RS01305	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SPN994039_RS01320	COG0201	protein transport
SPN994039_RS01330	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SPN994039_RS01335	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SPN994039_RS01345	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SPN994039_RS01350	COG0202	RNA polymerase activity
SPN994039_RS01360	COG3830	Belongs to the UPF0237 family
SPN994039_RS01380	COG1178	ABC-type Fe3 transport system permease component
SPN994039_RS01385	COG3842	ATPase activity
SPN994039_RS01405	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPN994039_RS01410	COG1349	DNA-binding transcription factor activity
SPN994039_RS01420	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPN994039_RS01425	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN994039_RS01430	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN994039_RS01435	COG1882	Formate acetyltransferase
SPN994039_RS01485	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPN994039_RS01490	COG4589	Belongs to the CDS family
SPN994039_RS01495	COG0750	zinc metalloprotease
SPN994039_RS01505	COG2723	6-phospho-beta-galactosidase activity
SPN994039_RS01510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPN994039_RS01520	COG1523	belongs to the glycosyl hydrolase 13 family
SPN994039_RS01540	COG2176	DNA-directed DNA polymerase activity
SPN994039_RS01560	COG2309	aminopeptidase activity
SPN994039_RS01565	COG2261	transglycosylase associated protein
SPN994039_RS01570	COG1187	pseudouridine synthase activity
SPN994039_RS01580	COG3579	cysteine-type endopeptidase activity
SPN994039_RS01585	COG3716	PTS system mannose fructose sorbose family IID component
SPN994039_RS01590	COG3715	PTS system
SPN994039_RS01600	COG1064	alcohol dehydrogenase
SPN994039_RS01605	COG0561	phosphatase activity
SPN994039_RS01610	COG2252	PERMEase
SPN994039_RS01620	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SPN994039_RS01625	COG0285	dihydrofolate synthase activity
SPN994039_RS01630	COG0302	gtp cyclohydrolase
SPN994039_RS01635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SPN994039_RS01635	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPN994039_RS01645	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPN994039_RS01660	COG2723	6-phospho-beta-galactosidase activity
SPN994039_RS01675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPN994039_RS01675	COG3711	transcriptional antiterminator
SPN994039_RS01690	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN994039_RS01705	COG0386	Belongs to the glutathione peroxidase family
SPN994039_RS01720	COG0800	Aldolase
SPN994039_RS01735	COG1028	Short-chain dehydrogenase reductase Sdr
SPN994039_RS01745	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SPN994039_RS01750	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN994039_RS01755	COG3715	PTS system
SPN994039_RS01760	COG3716	PTS system mannose fructose sorbose family IID component
SPN994039_RS01775	COG1609	Transcriptional regulator
SPN994039_RS01805	COG4839	cell division protein FtsL
SPN994039_RS01810	COG0768	penicillin binding
SPN994039_RS01835	COG0366	Alpha amylase catalytic
SPN994039_RS01840	COG4166	transmembrane transport
SPN994039_RS01895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPN994039_RS01900	COG4166	transmembrane transport
SPN994039_RS01905	COG0366	Alpha amylase catalytic
SPN994039_RS01910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPN994039_RS01935	COG0116	Belongs to the methyltransferase superfamily
SPN994039_RS01945	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SPN994039_RS01950	COG0745	RESPONSE REGULATOR receiver
SPN994039_RS02005	COG4585	Histidine kinase
SPN994039_RS02010	COG2197	response regulator
SPN994039_RS02040	COG0582	viral genome integration into host DNA
SPN994039_RS02050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPN994039_RS02055	COG0681	Belongs to the peptidase S26 family
SPN994039_RS02080	COG1115	amino acid carrier protein
SPN994039_RS02095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SPN994039_RS02105	COG0527	aspartate kinase activity
SPN994039_RS02110	COG1024	Enoyl-CoA hydratase
SPN994039_RS02115	COG1846	Transcriptional regulator
SPN994039_RS02125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPN994039_RS02135	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPN994039_RS02140	COG1028	Short-chain dehydrogenase reductase Sdr
SPN994039_RS02145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPN994039_RS02160	COG0439	Biotin carboxylase
SPN994039_RS02165	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPN994039_RS02235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SPN994039_RS02245	COG1461	Dihydroxyacetone kinase
SPN994039_RS02250	COG0028	Belongs to the TPP enzyme family
SPN994039_RS02255	COG0440	acetolactate synthase activity
SPN994039_RS02275	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SPN994039_RS02290	COG0765	amino acid transport
SPN994039_RS02320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPN994039_RS02325	COG1882	Formate acetyltransferase
SPN994039_RS02360	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPN994039_RS02365	COG0569	domain protein
SPN994039_RS02385	COG1122	ATPase activity
SPN994039_RS02400	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPN994039_RS02405	COG0671	phosphoesterase, PA-phosphatase related
SPN994039_RS02415	COG1247	-acetyltransferase
SPN994039_RS02430	COG0504	CTP synthase activity
SPN994039_RS02435	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPN994039_RS02455	COG0789	Transcriptional regulator
SPN994039_RS02460	COG0174	glutamine synthetase
SPN994039_RS02470	COG0732	type I restriction modification DNA specificity domain
SPN994039_RS02475	COG4974	Belongs to the 'phage' integrase family
SPN994039_RS02535	COG0484	heat shock protein binding
SPN994039_RS02550	COG0537	adenosine 5'-monophosphoramidase activity
SPN994039_RS02555	COG1131	(ABC) transporter
SPN994039_RS02560	COG4473	ABC transporter
SPN994039_RS02580	COG3290	protein histidine kinase activity
SPN994039_RS02590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPN994039_RS02600	COG2274	protein secretion by the type I secretion system
SPN994039_RS02640	COG1266	CAAX protease self-immunity
SPN994039_RS02660	COG0195	Participates in both transcription termination and antitermination
SPN994039_RS02665	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPN994039_RS02730	COG0519	Catalyzes the synthesis of GMP from XMP
SPN994039_RS02740	COG0525	valine-tRNA ligase activity
SPN994039_RS02755	COG2801	Transposase and inactivated derivatives
SPN994039_RS02760	COG2801	Transposase and inactivated derivatives
SPN994039_RS02780	COG3711	transcriptional antiterminator
SPN994039_RS02785	COG2190	(PTS) system
SPN994039_RS02785	COG1263	PTS System
SPN994039_RS02785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN994039_RS02805	COG0456	acetyltransferase
SPN994039_RS02810	COG0072	phenylalanine-tRNA ligase activity
SPN994039_RS02810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPN994039_RS02830	COG3620	sequence-specific DNA binding
SPN994039_RS02835	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SPN994039_RS02850	COG1045	serine acetyltransferase
SPN994039_RS02860	COG0215	cysteine-tRNA ligase activity
SPN994039_RS02865	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPN994039_RS02885	COG0577	efflux transmembrane transporter activity
SPN994039_RS02890	COG1136	(ABC) transporter
SPN994039_RS02895	COG0577	efflux transmembrane transporter activity
SPN994039_RS02900	COG0745	RESPONSE REGULATOR receiver
SPN994039_RS02905	COG5002	protein histidine kinase activity
SPN994039_RS02910	COG0191	fructose-bisphosphate aldolase activity
SPN994039_RS02920	COG0765	amino acid transport
SPN994039_RS02925	COG0765	amino acid transport
SPN994039_RS02930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN994039_RS02940	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPN994039_RS02940	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPN994039_RS02970	COG0322	excinuclease ABC activity
SPN994039_RS02980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN994039_RS02995	COG1573	uracil-dna glycosylase
SPN994039_RS03005	COG1114	Component of the transport system for branched-chain amino acids
SPN994039_RS03010	COG1363	Peptidase, m42
SPN994039_RS03055	COG4555	ABC transporter
SPN994039_RS03090	COG1404	Belongs to the peptidase S8 family
SPN994039_RS03105	COG3775	system Galactitol-specific IIC component
SPN994039_RS03115	COG3250	beta-galactosidase activity
SPN994039_RS03135	COG1242	4 iron, 4 sulfur cluster binding
SPN994039_RS03140	COG1242	4 iron, 4 sulfur cluster binding
SPN994039_RS03145	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPN994039_RS03165	COG0785	Cytochrome C biogenesis protein
SPN994039_RS03170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPN994039_RS03175	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPN994039_RS03175	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPN994039_RS03180	COG2207	Transcriptional regulator
SPN994039_RS03180	COG4753	response regulator
SPN994039_RS03185	COG2972	Histidine kinase
SPN994039_RS03195	COG3064	Membrane
SPN994039_RS03200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPN994039_RS03215	COG1940	carbohydrate kinase activity
SPN994039_RS03230	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SPN994039_RS03235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPN994039_RS03240	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPN994039_RS03250	COG0300	oxidoreductase activity
SPN994039_RS03265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPN994039_RS03275	COG1187	pseudouridine synthase activity
SPN994039_RS03280	COG1217	gtp-binding protein TYPA
SPN994039_RS03300	COG1136	(ABC) transporter
SPN994039_RS03315	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SPN994039_RS03325	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SPN994039_RS03350	COG1131	(ABC) transporter
SPN994039_RS03355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN994039_RS03360	COG1126	abc transporter atp-binding protein
SPN994039_RS03365	COG1129	ABC transporter
SPN994039_RS03370	COG4215	(ABC) transporter
SPN994039_RS03375	COG4597	amino acid ABC transporter
SPN994039_RS03380	COG1304	FMN binding
SPN994039_RS03390	COG1304	FMN binding
SPN994039_RS03405	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SPN994039_RS03410	COG0352	thiamine-phosphate diphosphorylase activity
SPN994039_RS03420	COG4172	Belongs to the ABC transporter superfamily
SPN994039_RS03430	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SPN994039_RS03445	COG0352	thiamine-phosphate diphosphorylase activity
SPN994039_RS03465	COG2217	Heavy metal translocating P-type atpase
SPN994039_RS03470	COG0028	Belongs to the TPP enzyme family
SPN994039_RS03490	COG2723	6-phospho-beta-galactosidase activity
SPN994039_RS03495	COG1482	cell wall glycoprotein biosynthetic process
SPN994039_RS03500	COG0733	neurotransmitter:sodium symporter activity
SPN994039_RS03510	COG0789	Transcriptional regulator
SPN994039_RS03520	COG2081	HI0933 family
SPN994039_RS03525	COG1307	EDD domain protein, DegV family
SPN994039_RS03535	COG2131	deaminase
SPN994039_RS03540	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SPN994039_RS03580	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPN994039_RS03580	COG0617	tRNA 3'-terminal CCA addition
SPN994039_RS03580	COG0517	IMP dehydrogenase activity
SPN994039_RS03585	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SPN994039_RS03590	COG2884	Cell division ATP-binding protein ftsE
SPN994039_RS03595	COG2177	Part of the ABC transporter FtsEX involved in
SPN994039_RS03600	COG2190	(PTS) system
SPN994039_RS03600	COG1263	PTS System
SPN994039_RS03600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN994039_RS03610	COG0513	Belongs to the DEAD box helicase family
SPN994039_RS03620	COG0167	dihydroorotate dehydrogenase activity
SPN994039_RS03630	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SPN994039_RS03635	COG4470	Protein conserved in bacteria
SPN994039_RS03650	COG0488	(ABC) transporter
SPN994039_RS03655	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SPN994039_RS03675	COG1837	Belongs to the UPF0109 family
SPN994039_RS03695	COG1328	CTP reductase activity
SPN994039_RS03695	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPN994039_RS03705	COG4443	Transcriptional Coactivator p15 (PC4)
SPN994039_RS03715	COG1268	BioY protein
SPN994039_RS03720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPN994039_RS03725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPN994039_RS03730	COG1136	(ABC) transporter
SPN994039_RS03735	COG0577	efflux transmembrane transporter activity
SPN994039_RS03740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPN994039_RS03740	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPN994039_RS03760	COG4989	oxidoreductase activity
SPN994039_RS03770	COG1028	Short-chain dehydrogenase reductase Sdr
SPN994039_RS03800	COG0745	RESPONSE REGULATOR receiver
SPN994039_RS03805	COG5002	protein histidine kinase activity
SPN994039_RS03820	COG1199	ATP-dependent helicase activity
SPN994039_RS03820	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SPN994039_RS03825	COG0772	Belongs to the SEDS family
SPN994039_RS03830	COG0693	protein deglycase activity
SPN994039_RS03840	COG0187	DNA topoisomerase II activity
SPN994039_RS03860	COG0494	nUDIX hydrolase
SPN994039_RS03875	COG0542	response to heat
SPN994039_RS03880	COG4703	Protein of unknown function (DUF1797)
SPN994039_RS03885	COG0765	amino acid transport
SPN994039_RS03890	COG1126	abc transporter atp-binding protein
SPN994039_RS03895	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPN994039_RS03900	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SPN994039_RS03920	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SPN994039_RS03965	COG2813	Specifically methylates the guanine in position
SPN994039_RS03970	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SPN994039_RS03980	COG0295	cytidine deaminase activity
SPN994039_RS03985	COG1744	ABC transporter substrate-binding protein PnrA-like
SPN994039_RS03990	COG3845	ABC transporter
SPN994039_RS03995	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPN994039_RS04000	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPN994039_RS04015	COG2801	Transposase and inactivated derivatives
SPN994039_RS04020	COG2801	Transposase and inactivated derivatives
SPN994039_RS04035	COG0187	DNA topoisomerase II activity
SPN994039_RS04045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPN994039_RS04050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPN994039_RS04055	COG4166	transmembrane transport
SPN994039_RS04090	COG0539	negative regulation of cytoplasmic translation
SPN994039_RS04110	COG1956	GAF domain-containing protein
SPN994039_RS04115	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPN994039_RS04130	COG0719	Fe-S assembly protein
SPN994039_RS04135	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPN994039_RS04145	COG0719	Fe-S assembly protein
SPN994039_RS04155	COG1686	Belongs to the peptidase S11 family
SPN994039_RS04160	COG0628	permease
SPN994039_RS04170	COG1349	DNA-binding transcription factor activity
SPN994039_RS04175	COG1105	Belongs to the carbohydrate kinase PfkB family
SPN994039_RS04180	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPN994039_RS04180	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPN994039_RS04180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPN994039_RS04185	COG0697	spore germination
SPN994039_RS04185	COG1674	ftsk spoiiie
SPN994039_RS04195	COG1104	cysteine desulfurase activity
SPN994039_RS04265	COG1438	arginine binding
SPN994039_RS04285	COG0469	pyruvate kinase activity
SPN994039_RS04290	COG0582	viral genome integration into host DNA
SPN994039_RS04325	COG3689	TIGRFAM TIGR03943 family protein
SPN994039_RS04330	COG0701	Predicted permease
SPN994039_RS04340	COG2183	response to ionizing radiation
SPN994039_RS04360	COG1136	(ABC) transporter
SPN994039_RS04365	COG0577	efflux transmembrane transporter activity
SPN994039_RS04380	COG1982	Orn Lys Arg decarboxylase major
SPN994039_RS04395	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SPN994039_RS04415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPN994039_RS04420	COG0561	phosphatase activity
SPN994039_RS04440	COG0583	DNA-binding transcription factor activity
SPN994039_RS04445	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPN994039_RS04450	COG0564	pseudouridine synthase activity
SPN994039_RS04455	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPN994039_RS04470	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPN994039_RS04480	COG0470	DNA polymerase III
SPN994039_RS04525	COG0528	UMP kinase activity
SPN994039_RS04535	COG2996	Protein conserved in bacteria
SPN994039_RS04545	COG1702	phosphate starvation-inducible protein PhoH
SPN994039_RS04560	COG0686	Belongs to the AlaDH PNT family
SPN994039_RS04565	COG0686	Belongs to the AlaDH PNT family
SPN994039_RS04570	COG0686	Belongs to the AlaDH PNT family
SPN994039_RS04575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPN994039_RS04580	COG1596	polysaccharide export
SPN994039_RS04580	COG1555	photosystem II stabilization
SPN994039_RS04585	COG2333	competence protein COMEC
SPN994039_RS04585	COG0658	competence protein
SPN994039_RS04595	COG1131	(ABC) transporter
SPN994039_RS04625	COG0543	2 iron, 2 sulfur cluster binding
SPN994039_RS04630	COG0167	dihydroorotate dehydrogenase activity
SPN994039_RS04635	COG5263	repeat protein
SPN994039_RS04635	COG4193	domain, Protein
SPN994039_RS04640	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPN994039_RS04650	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPN994039_RS04660	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPN994039_RS04665	COG0237	dephospho-CoA kinase activity
SPN994039_RS04670	COG2814	Major facilitator Superfamily
SPN994039_RS04675	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPN994039_RS04685	COG0557	exoribonuclease II activity
SPN994039_RS04695	COG3615	Tellurite resistance protein tehB
SPN994039_RS04695	COG0500	methyltransferase
SPN994039_RS04710	COG4122	O-methyltransferase activity
SPN994039_RS04720	COG2801	Transposase and inactivated derivatives
SPN994039_RS04735	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SPN994039_RS04755	COG0494	nUDIX hydrolase
SPN994039_RS04765	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPN994039_RS04775	COG2176	DNA-directed DNA polymerase activity
SPN994039_RS04780	COG0584	glycerophosphoryl diester phosphodiesterase
SPN994039_RS04800	COG0785	Cytochrome C biogenesis protein
SPN994039_RS04805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPN994039_RS04810	COG0531	amino acid
SPN994039_RS04815	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPN994039_RS04815	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPN994039_RS04860	COG1970	mechanosensitive ion channel activity
SPN994039_RS04870	COG4708	membrane
SPN994039_RS04880	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPN994039_RS04890	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SPN994039_RS04895	COG1942	4-Oxalocrotonate Tautomerase
SPN994039_RS04900	COG1435	thymidine kinase activity
SPN994039_RS04905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SPN994039_RS04910	COG2890	protein-(glutamine-N5) methyltransferase activity
SPN994039_RS04935	COG0741	lytic transglycosylase activity
SPN994039_RS04945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPN994039_RS04965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPN994039_RS04970	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPN994039_RS05020	COG1597	lipid kinase activity
SPN994039_RS05025	COG0366	Alpha amylase catalytic
SPN994039_RS05040	COG1396	sequence-specific DNA binding
SPN994039_RS05045	COG0542	response to heat
SPN994039_RS05050	COG0613	PHP domain protein
SPN994039_RS05075	COG1181	Belongs to the D-alanine--D-alanine ligase family
SPN994039_RS05080	COG0148	phosphopyruvate hydratase activity
SPN994039_RS05085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPN994039_RS05090	COG3959	Transketolase, thiamine diphosphate binding domain
SPN994039_RS05095	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPN994039_RS05100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SPN994039_RS05110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SPN994039_RS05125	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
SPN994039_RS05125	COG0028	Belongs to the TPP enzyme family
SPN994039_RS05140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPN994039_RS05150	COG4555	ABC transporter
SPN994039_RS05165	COG2723	6-phospho-beta-galactosidase activity
SPN994039_RS05170	COG1396	sequence-specific DNA binding
SPN994039_RS05195	COG0772	Belongs to the SEDS family
SPN994039_RS05200	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SPN994039_RS05215	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPN994039_RS05220	COG0358	DNA primase activity
SPN994039_RS05225	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPN994039_RS05230	COG2151	metal-sulfur cluster biosynthetic enzyme
SPN994039_RS05235	COG0438	transferase activity, transferring glycosyl groups
SPN994039_RS05240	COG0438	transferase activity, transferring glycosyl groups
SPN994039_RS05265	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPN994039_RS05275	COG4109	DRTGG domain
SPN994039_RS05280	COG0024	Methionine aminopeptidase
SPN994039_RS05295	COG0210	DNA helicase
SPN994039_RS05305	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPN994039_RS05325	COG1104	cysteine desulfurase activity
SPN994039_RS05330	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPN994039_RS05340	COG2357	RelA SpoT domain protein
SPN994039_RS05350	COG0564	pseudouridine synthase activity
SPN994039_RS05355	COG0280	phosphate acetyltransferase
SPN994039_RS05395	COG0196	riboflavin kinase activity
SPN994039_RS05400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPN994039_RS05405	COG1307	EDD domain protein, DegV family
SPN994039_RS05415	COG0488	(ABC) transporter
SPN994039_RS05435	COG1523	belongs to the glycosyl hydrolase 13 family
SPN994039_RS05445	COG1012	belongs to the aldehyde dehydrogenase family
SPN994039_RS05450	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SPN994039_RS05460	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SPN994039_RS05470	COG0560	Phosphoserine phosphatase
SPN994039_RS05475	COG0560	Phosphoserine phosphatase
SPN994039_RS05495	COG0582	viral genome integration into host DNA
SPN994039_RS05520	COG1074	ATP-dependent DNA helicase activity
SPN994039_RS05535	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPN994039_RS05540	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SPN994039_RS05555	COG0095	Lipoate-protein ligase
SPN994039_RS05560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPN994039_RS05565	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPN994039_RS05570	COG0022	dehydrogenase e1 component
SPN994039_RS05575	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPN994039_RS05580	COG0534	Mate efflux family protein
SPN994039_RS05590	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPN994039_RS05595	COG1051	belongs to the nudix hydrolase family
SPN994039_RS05610	COG1011	Hydrolase
SPN994039_RS05615	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SPN994039_RS05630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPN994039_RS05635	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPN994039_RS05640	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPN994039_RS05645	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPN994039_RS05675	COG3711	transcriptional antiterminator
SPN994039_RS05680	COG3684	Belongs to the aldolase LacD family
SPN994039_RS05735	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SPN994039_RS05740	COG0497	DNA recombination
SPN994039_RS05745	COG1438	arginine binding
SPN994039_RS05750	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPN994039_RS05785	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SPN994039_RS05805	COG3764	Sortase (surface protein transpeptidase)
SPN994039_RS05810	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPN994039_RS05820	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SPN994039_RS05835	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPN994039_RS05840	COG5002	protein histidine kinase activity
SPN994039_RS05845	COG0745	RESPONSE REGULATOR receiver
SPN994039_RS05850	COG1194	a g-specific adenine glycosylase
SPN994039_RS05865	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPN994039_RS05870	COG4684	Psort location CytoplasmicMembrane, score
SPN994039_RS05880	COG1827	regulation of RNA biosynthetic process
SPN994039_RS05910	COG0765	amino acid transport
SPN994039_RS05915	COG1126	abc transporter atp-binding protein
SPN994039_RS05920	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPN994039_RS05925	COG0552	protein localization to endoplasmic reticulum
SPN994039_RS05930	COG0561	phosphatase activity
SPN994039_RS05935	COG0561	phosphatase activity
SPN994039_RS05940	COG1196	nuclear chromosome segregation
SPN994039_RS05965	COG1401	restriction endodeoxyribonuclease activity
SPN994039_RS05980	COG0066	3-isopropylmalate dehydratase activity
SPN994039_RS06010	COG3142	Participates in the control of copper homeostasis
SPN994039_RS06015	COG2832	Protein of unknown function (DUF454)
SPN994039_RS06020	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPN994039_RS06030	COG0758	DNA mediated transformation
SPN994039_RS06035	COG4750	Nucleotidyl transferase
SPN994039_RS06050	COG1063	alcohol dehydrogenase
SPN994039_RS06065	COG3475	LICD family
SPN994039_RS06070	COG3475	LICD family
SPN994039_RS06080	COG0505	Belongs to the CarA family
SPN994039_RS06095	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPN994039_RS06110	COG0488	(ABC) transporter
SPN994039_RS06120	COG1704	LemA family
SPN994039_RS06135	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPN994039_RS06150	COG1078	dGTPase activity
SPN994039_RS06170	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPN994039_RS06175	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPN994039_RS06180	COG0077	Prephenate dehydratase
SPN994039_RS06180	COG1605	Chorismate mutase
SPN994039_RS06185	COG0716	FMN binding
SPN994039_RS06190	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPN994039_RS06210	COG3335	DDE superfamily endonuclease
SPN994039_RS06220	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPN994039_RS06250	COG3335	DDE superfamily endonuclease
SPN994039_RS06280	COG1136	(ABC) transporter
SPN994039_RS06280	COG0577	efflux transmembrane transporter activity
SPN994039_RS06290	COG0515	serine threonine protein kinase
SPN994039_RS06330	COG0402	S-adenosylhomocysteine deaminase activity
SPN994039_RS06340	COG1132	(ABC) transporter
SPN994039_RS06345	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPN994039_RS06345	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPN994039_RS06380	COG1215	transferase activity, transferring glycosyl groups
SPN994039_RS06390	COG3475	LICD family
SPN994039_RS06400	COG0077	Prephenate dehydratase
SPN994039_RS06405	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SPN994039_RS06420	COG0287	Prephenate dehydrogenase
SPN994039_RS06445	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPN994039_RS06455	COG1131	(ABC) transporter
SPN994039_RS06495	COG3842	ATPase activity
SPN994039_RS06510	COG3527	Alpha-acetolactate decarboxylase
SPN994039_RS06515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPN994039_RS06520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN994039_RS06525	COG0704	Plays a role in the regulation of phosphate uptake
SPN994039_RS06530	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPN994039_RS06535	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPN994039_RS06540	COG0581	inorganic phosphate transmembrane transporter activity
SPN994039_RS06545	COG0573	inorganic phosphate transmembrane transporter activity
SPN994039_RS06550	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPN994039_RS06555	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPN994039_RS06555	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPN994039_RS06560	COG0483	inositol monophosphate 1-phosphatase activity
SPN994039_RS06570	COG1393	Belongs to the ArsC family
SPN994039_RS06580	COG0647	UMP catabolic process
SPN994039_RS06590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPN994039_RS06625	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SPN994039_RS06635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPN994039_RS06645	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPN994039_RS06680	COG0826	peptidase U32
SPN994039_RS06705	COG1132	(ABC) transporter
SPN994039_RS06710	COG1132	(ABC) transporter
SPN994039_RS06725	COG1129	ABC transporter
SPN994039_RS06735	COG4372	Transposase
SPN994039_RS06770	COG2188	Transcriptional regulator
SPN994039_RS06775	COG0697	spore germination
SPN994039_RS06780	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPN994039_RS06795	COG0561	phosphatase activity
SPN994039_RS06825	COG0492	ferredoxin-NADP+ reductase activity
SPN994039_RS06835	COG1126	abc transporter atp-binding protein
SPN994039_RS06845	COG1393	Belongs to the ArsC family
SPN994039_RS06850	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SPN994039_RS06865	COG1272	protein, Hemolysin III
SPN994039_RS06905	COG0751	glycine-tRNA ligase activity
SPN994039_RS06920	COG0656	L-ascorbic acid biosynthetic process
SPN994039_RS06925	COG0726	polysaccharide deacetylase
SPN994039_RS06945	COG3335	DDE superfamily endonuclease
SPN994039_RS06960	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPN994039_RS06995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPN994039_RS07005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPN994039_RS07010	COG1126	abc transporter atp-binding protein
SPN994039_RS07025	COG0628	permease
SPN994039_RS07030	COG2706	6-phosphogluconolactonase activity
SPN994039_RS07045	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SPN994039_RS07100	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPN994039_RS07125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPN994039_RS07130	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SPN994039_RS07135	COG0626	cystathionine gamma-synthase activity
SPN994039_RS07140	COG1132	(ABC) transporter
SPN994039_RS07145	COG1132	(ABC) transporter
SPN994039_RS07155	COG4166	transmembrane transport
SPN994039_RS07160	COG2244	polysaccharide biosynthetic process
SPN994039_RS07165	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPN994039_RS07190	COG2827	Endonuclease containing a URI domain
SPN994039_RS07195	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPN994039_RS07200	COG1098	S1 RNA binding domain
SPN994039_RS07210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPN994039_RS07215	COG0629	single-stranded DNA binding
SPN994039_RS07225	COG0017	Asparaginyl-tRNA synthetase
SPN994039_RS07235	COG0436	Aminotransferase
SPN994039_RS07270	COG0242	peptide deformylase activity
SPN994039_RS07275	COG0625	glutathione transferase activity
SPN994039_RS07285	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPN994039_RS07290	COG0488	(ABC) transporter
SPN994039_RS07295	COG0617	tRNA 3'-terminal CCA addition
SPN994039_RS07305	COG1307	EDD domain protein, DegV family
SPN994039_RS07325	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPN994039_RS07345	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SPN994039_RS07355	COG0251	oxidation-reduction process
SPN994039_RS07375	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPN994039_RS07395	COG3935	DnaD domain protein
SPN994039_RS07410	COG2226	methyltransferase
SPN994039_RS07420	COG3842	ATPase activity
SPN994039_RS07430	COG1335	isochorismatase
SPN994039_RS07440	COG0513	Belongs to the DEAD box helicase family
SPN994039_RS07445	COG2223	nitrite transmembrane transporter activity
SPN994039_RS07450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPN994039_RS07455	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPN994039_RS07460	COG3442	glutamine amidotransferase
SPN994039_RS07465	COG0006	proline dipeptidase activity
SPN994039_RS07470	COG2801	Transposase and inactivated derivatives
SPN994039_RS07475	COG2801	Transposase and inactivated derivatives
SPN994039_RS07490	COG4720	Psort location CytoplasmicMembrane, score
SPN994039_RS07495	COG0351	phosphomethylpyrimidine kinase
SPN994039_RS07520	COG2824	Alkylphosphonate utilization operon protein PhnA
SPN994039_RS07540	COG0463	Glycosyl transferase, family 2
SPN994039_RS07545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPN994039_RS07555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPN994039_RS07560	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SPN994039_RS07565	COG2384	SAM-dependent methyltransferase
SPN994039_RS07580	COG2801	Transposase and inactivated derivatives
SPN994039_RS07585	COG2801	Transposase and inactivated derivatives
SPN994039_RS07600	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SPN994039_RS07605	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SPN994039_RS07610	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
SPN994039_RS07610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPN994039_RS07610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPN994039_RS07615	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPN994039_RS07635	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SPN994039_RS07640	COG0204	Acyl-transferase
SPN994039_RS07655	COG2910	NAD(P)H-binding
SPN994039_RS07675	COG5002	protein histidine kinase activity
SPN994039_RS07680	COG0745	RESPONSE REGULATOR receiver
SPN994039_RS07695	COG1959	2 iron, 2 sulfur cluster binding
SPN994039_RS07755	COG3590	peptidase
SPN994039_RS07770	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPN994039_RS07775	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SPN994039_RS07790	COG0577	efflux transmembrane transporter activity
SPN994039_RS07790	COG1136	(ABC) transporter
SPN994039_RS07835	COG3599	regulation of cell shape
SPN994039_RS07855	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPN994039_RS07875	COG1051	belongs to the nudix hydrolase family
SPN994039_RS07880	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPN994039_RS07895	COG0768	penicillin binding
SPN994039_RS07910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPN994039_RS07925	COG2731	YhcH YjgK YiaL family protein
SPN994039_RS07930	COG0395	ABC-type sugar transport system, permease component
SPN994039_RS07935	COG1175	transmembrane transport
SPN994039_RS07945	COG1263	PTS System
SPN994039_RS07945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN994039_RS07945	COG2190	(PTS) system
SPN994039_RS07955	COG0673	inositol 2-dehydrogenase activity
SPN994039_RS07960	COG4409	exo-alpha-(2->6)-sialidase activity
SPN994039_RS07970	COG1175	transmembrane transport
SPN994039_RS07975	COG1653	transport
SPN994039_RS07995	COG3458	cephalosporin-C deacetylase activity
SPN994039_RS08000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPN994039_RS08015	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPN994039_RS08020	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPN994039_RS08025	COG0653	protein targeting
SPN994039_RS08035	COG1131	(ABC) transporter
SPN994039_RS08065	COG0778	Nitroreductase
SPN994039_RS08070	COG1484	DNA-dependent DNA replication
SPN994039_RS08085	COG1725	Transcriptional regulator
SPN994039_RS08090	COG1131	(ABC) transporter
SPN994039_RS08100	COG1668	transmembrane transport
SPN994039_RS08105	COG4152	abc transporter atp-binding protein
SPN994039_RS08120	COG1940	carbohydrate kinase activity
SPN994039_RS08125	COG1263	PTS System
SPN994039_RS08125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN994039_RS08125	COG2190	(PTS) system
SPN994039_RS08135	COG1621	beta-fructofuranosidase activity
SPN994039_RS08140	COG1609	Transcriptional regulator
SPN994039_RS08150	COG3425	synthase
SPN994039_RS08180	COG2815	serine threonine protein kinase
SPN994039_RS08180	COG0515	serine threonine protein kinase
SPN994039_RS08185	COG0631	protein serine/threonine phosphatase activity
SPN994039_RS08190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPN994039_RS08190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPN994039_RS08200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPN994039_RS08210	COG0194	GDP metabolic process
SPN994039_RS08225	COG1323	Belongs to the UPF0348 family
SPN994039_RS08230	COG2226	methyltransferase
SPN994039_RS08235	COG0799	negative regulation of ribosome biogenesis
SPN994039_RS08245	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPN994039_RS08250	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SPN994039_RS08255	COG1534	Rna-binding protein
SPN994039_RS08260	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPN994039_RS08275	COG0668	transmembrane transport
SPN994039_RS08300	COG3118	belongs to the thioredoxin family
SPN994039_RS08305	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SPN994039_RS08315	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPN994039_RS08330	COG1164	Oligoendopeptidase f
SPN994039_RS08335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPN994039_RS08345	COG1051	belongs to the nudix hydrolase family
SPN994039_RS08380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPN994039_RS08435	COG1621	beta-fructofuranosidase activity
SPN994039_RS08440	COG1653	transport
SPN994039_RS08445	COG0395	ABC-type sugar transport system, permease component
SPN994039_RS08450	COG4209	transmembrane transport
SPN994039_RS08460	COG3711	transcriptional antiterminator
SPN994039_RS08485	COG3237	CsbD-like
SPN994039_RS08505	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPN994039_RS08515	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN994039_RS08520	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPN994039_RS08525	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN994039_RS08535	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN994039_RS08540	COG1940	carbohydrate kinase activity
SPN994039_RS08540	COG1846	Transcriptional regulator
SPN994039_RS08550	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SPN994039_RS08590	COG0512	Glutamine amidotransferase of anthranilate synthase
SPN994039_RS08595	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPN994039_RS08620	COG1285	pathogenesis
SPN994039_RS08625	COG1178	ABC-type Fe3 transport system permease component
SPN994039_RS08650	COG5434	Belongs to the glycosyl hydrolase 28 family
SPN994039_RS08665	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SPN994039_RS08670	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPN994039_RS08675	COG1132	(ABC) transporter
SPN994039_RS08680	COG1132	(ABC) transporter
SPN994039_RS08705	COG0708	Exodeoxyribonuclease III
SPN994039_RS08725	COG2233	PERMEase
SPN994039_RS08750	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPN994039_RS08755	COG1609	Transcriptional regulator
SPN994039_RS08760	COG1063	alcohol dehydrogenase
SPN994039_RS08765	COG0789	Transcriptional regulator
SPN994039_RS08770	COG1230	cation diffusion facilitator family transporter
SPN994039_RS08780	COG3201	nicotinamide mononucleotide transporter
SPN994039_RS08785	COG1174	glycine betaine transport
SPN994039_RS08810	COG1363	Peptidase, m42
SPN994039_RS08815	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPN994039_RS08825	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPN994039_RS08830	COG4605	iron ion homeostasis
SPN994039_RS08835	COG4604	ABC transporter, ATP-binding protein
SPN994039_RS08840	COG4607	ABC-type enterochelin transport system periplasmic component
SPN994039_RS08850	COG1187	pseudouridine synthase activity
SPN994039_RS08880	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SPN994039_RS08895	COG0366	Alpha amylase catalytic
SPN994039_RS08900	COG1263	PTS System
SPN994039_RS08900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPN994039_RS08905	COG2188	Transcriptional regulator
SPN994039_RS08925	COG4608	Belongs to the ABC transporter superfamily
SPN994039_RS08930	COG0444	Belongs to the ABC transporter superfamily
SPN994039_RS08935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPN994039_RS08940	COG0601	transmembrane transport
SPN994039_RS08945	COG4166	transmembrane transport
SPN994039_RS08955	COG0366	Alpha amylase catalytic
SPN994039_RS08965	COG0395	ABC-type sugar transport system, permease component
SPN994039_RS08970	COG1175	transmembrane transport
SPN994039_RS08975	COG1653	transport
SPN994039_RS08980	COG3345	alpha-galactosidase
SPN994039_RS08985	COG2207	Transcriptional regulator
SPN994039_RS08990	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPN994039_RS08990	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPN994039_RS09105	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPN994039_RS09145	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SPN994039_RS09155	COG4221	oxidoreductase activity
SPN994039_RS09160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPN994039_RS09165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPN994039_RS09200	COG1132	(ABC) transporter
SPN994039_RS09290	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPN994039_RS09290	COG5263	repeat protein
SPN994039_RS09310	COG1316	TRANSCRIPTIONal
SPN994039_RS09320	COG0802	atpase or kinase
SPN994039_RS09345	COG1136	(ABC) transporter
SPN994039_RS09345	COG0577	efflux transmembrane transporter activity
SPN994039_RS09375	COG1253	flavin adenine dinucleotide binding
SPN994039_RS09390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPN994039_RS09395	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPN994039_RS09405	COG0742	ribosomal rna small subunit methyltransferase
SPN994039_RS09425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPN994039_RS09430	COG1254	Belongs to the acylphosphatase family
SPN994039_RS09440	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPN994039_RS09450	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPN994039_RS09465	COG1564	THIamine pyrophosphokinase
SPN994039_RS09475	COG1162	GTPase activity
SPN994039_RS09510	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SPN994039_RS09515	COG0084	hydrolase, TatD family'
SPN994039_RS09530	COG0436	Aminotransferase
SPN994039_RS09540	COG0589	response to stress
SPN994039_RS09545	COG0561	phosphatase activity
SPN994039_RS09550	COG0252	asparaginase activity
SPN994039_RS09560	COG1609	Transcriptional regulator
SPN994039_RS09565	COG2197	response regulator
SPN994039_RS09570	COG4585	Histidine kinase
SPN994039_RS09575	COG0842	Transport permease protein
SPN994039_RS09580	COG1131	(ABC) transporter
SPN994039_RS09680	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPN994039_RS09685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPN994039_RS09690	COG0564	pseudouridine synthase activity
SPN994039_RS09700	COG0577	efflux transmembrane transporter activity
SPN994039_RS09700	COG1136	(ABC) transporter
SPN994039_RS09720	COG0157	Belongs to the NadC ModD family
SPN994039_RS09730	COG4133	protoheme IX ABC transporter activity
SPN994039_RS09735	COG2188	Transcriptional regulator
SPN994039_RS09740	COG2723	6-phospho-beta-galactosidase activity
SPN994039_RS09745	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPN994039_RS09755	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPN994039_RS09760	COG1012	belongs to the aldehyde dehydrogenase family
SPN994039_RS09760	COG1454	alcohol dehydrogenase
SPN994039_RS09770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPN994039_RS09780	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SPN994039_RS09800	COG3623	hexulose-6-phosphate isomerase
SPN994039_RS09810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPN994039_RS09820	COG3037	sugar-specific permease SgaT UlaA
SPN994039_RS09830	COG1847	R3H domain protein
SPN994039_RS09835	COG0706	membrane insertase activity
SPN994039_RS09885	COG4537	Required for transformation and DNA binding
SPN994039_RS09890	COG1459	type II secretion system
SPN994039_RS09895	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPN994039_RS09905	COG1063	alcohol dehydrogenase
SPN994039_RS09930	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SPN994039_RS09935	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SPN994039_RS09940	COG3759	membrane
SPN994039_RS09955	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SPN994039_RS09955	COG0131	Imidazoleglycerol-phosphate dehydratase
SPN994039_RS09960	COG0534	Mate efflux family protein
SPN994039_RS10075	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPN994039_RS10080	COG1132	(ABC) transporter
SPN994039_RS10090	COG1132	(ABC) transporter
SPN994039_RS10100	COG1438	arginine binding
SPN994039_RS10120	COG0745	RESPONSE REGULATOR receiver
SPN994039_RS10125	COG5002	protein histidine kinase activity
SPN994039_RS10130	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPN994039_RS10135	COG0573	inorganic phosphate transmembrane transporter activity
SPN994039_RS10145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPN994039_RS10150	COG0704	Plays a role in the regulation of phosphate uptake
SPN994039_RS10170	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPN994039_RS10180	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPN994039_RS10195	COG0697	spore germination
SPN994039_RS10200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPN994039_RS10200	COG4499	WXG100 protein secretion system (Wss), protein YukC
SPN994039_RS10210	COG2217	Heavy metal translocating P-type atpase
SPN994039_RS10220	COG2226	methyltransferase
SPN994039_RS10245	COG0058	SHG alpha-glucan phosphorylase activity
SPN994039_RS10250	COG1640	4-alpha-glucanotransferase
SPN994039_RS10255	COG2182	Extracellular solute-binding protein
SPN994039_RS10260	COG1175	transmembrane transport
SPN994039_RS10265	COG3833	ABC-type maltose transport systems, permease component
SPN994039_RS10270	COG5521	maltodextrose utilization protein MalA
SPN994039_RS10275	COG1609	Transcriptional regulator
SPN994039_RS10280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPN994039_RS10315	COG1476	TRANSCRIPTIONal
SPN994039_RS10345	COG2151	metal-sulfur cluster biosynthetic enzyme
SPN994039_RS10360	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPN994039_RS10365	COG3959	Transketolase, thiamine diphosphate binding domain
SPN994039_RS10380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPN994039_RS10400	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPN994039_RS10415	COG0383	alpha-mannosidase activity
SPN994039_RS10425	COG3537	Alpha-1,2-mannosidase
SPN994039_RS10445	COG0549	Belongs to the carbamate kinase family
SPN994039_RS10450	COG1288	antiporter activity
SPN994039_RS10455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPN994039_RS10470	COG3583	domain protein
SPN994039_RS10470	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPN994039_RS10470	COG3064	Membrane
SPN994039_RS10485	COG1454	alcohol dehydrogenase
SPN994039_RS10490	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
SPN994039_RS10495	COG0235	Class ii aldolase
SPN994039_RS10525	COG1175	transmembrane transport
SPN994039_RS10530	COG1653	transport
SPN994039_RS10535	COG1070	Carbohydrate kinase
SPN994039_RS10545	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPN994039_RS10545	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPN994039_RS10550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPN994039_RS10555	COG1121	(ABC) transporter
SPN994039_RS10560	COG1846	Transcriptional regulator
SPN994039_RS10565	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPN994039_RS10575	COG1696	Membrane protein involved in D-alanine export
SPN994039_RS10590	COG2211	Major facilitator Superfamily
SPN994039_RS10595	COG3344	reverse transcriptase
SPN994039_RS10610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPN994039_RS10615	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SPN994039_RS10635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPN994039_RS10645	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPN994039_RS10650	COG5002	protein histidine kinase activity
SPN994039_RS10655	COG0745	RESPONSE REGULATOR receiver
SPN994039_RS10665	COG0542	response to heat
SPN994039_RS10670	COG4463	regulation of RNA biosynthetic process
SPN994039_RS10675	COG1116	anion transmembrane transporter activity
SPN994039_RS10680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SPN994039_RS10685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SPN994039_RS10705	COG0305	Participates in initiation and elongation during chromosome replication
SPN994039_RS10725	COG1040	competence protein
SPN994039_RS10730	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPN994039_RS10735	COG1739	Uncharacterized protein family UPF0029
SPN994039_RS10750	COG3335	DDE superfamily endonuclease
SPN994039_RS10770	COG3942	CHAP domain
SPN994039_RS10780	COG1792	Involved in formation and maintenance of cell shape
SPN994039_RS10785	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPN994039_RS10790	COG1122	ATPase activity
SPN994039_RS10795	COG1122	ATPase activity
SPN994039_RS10800	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPN994039_RS10810	COG0612	Peptidase, M16
SPN994039_RS10815	COG0612	Peptidase, M16
SPN994039_RS10820	COG2501	S4 domain
SPN994039_RS10830	COG0516	GMP reductase activity
SPN994039_RS10830	COG0517	IMP dehydrogenase activity
SPN994039_RS10835	COG0180	Tryptophanyl-tRNA synthetase
SPN994039_RS10840	COG0488	(ABC) transporter
SPN994039_RS10850	COG1511	domain protein
SPN994039_RS10860	COG1511	domain protein
SPN994039_RS10905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPN994039_RS10910	COG1475	DNA binding