locus-tag	class	description
SPNA45_RS00010	COG0592	DNA-directed DNA polymerase activity
SPNA45_RS00020	COG0012	GTP binding
SPNA45_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPNA45_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPNA45_RS00060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SPNA45_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPNA45_RS00200	COG3935	DnaD domain protein
SPNA45_RS00240	COG0582	viral genome integration into host DNA
SPNA45_RS00360	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPNA45_RS00360	COG5263	repeat protein
SPNA45_RS00380	COG3537	Alpha-1,2-mannosidase
SPNA45_RS00390	COG0383	alpha-mannosidase activity
SPNA45_RS00425	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPNA45_RS00445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPNA45_RS00460	COG3959	Transketolase, thiamine diphosphate binding domain
SPNA45_RS00465	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPNA45_RS00480	COG2151	metal-sulfur cluster biosynthetic enzyme
SPNA45_RS00510	COG1476	TRANSCRIPTIONal
SPNA45_RS00540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPNA45_RS00550	COG1609	Transcriptional regulator
SPNA45_RS00555	COG5521	maltodextrose utilization protein MalA
SPNA45_RS00560	COG3833	ABC-type maltose transport systems, permease component
SPNA45_RS00565	COG1175	transmembrane transport
SPNA45_RS00570	COG2182	Extracellular solute-binding protein
SPNA45_RS00575	COG1640	4-alpha-glucanotransferase
SPNA45_RS00580	COG0058	SHG alpha-glucan phosphorylase activity
SPNA45_RS00600	COG2226	methyltransferase
SPNA45_RS00610	COG2217	Heavy metal translocating P-type atpase
SPNA45_RS00630	COG4499	WXG100 protein secretion system (Wss), protein YukC
SPNA45_RS00630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPNA45_RS00635	COG0697	spore germination
SPNA45_RS00650	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPNA45_RS00660	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPNA45_RS00680	COG0704	Plays a role in the regulation of phosphate uptake
SPNA45_RS00685	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPNA45_RS00695	COG0573	inorganic phosphate transmembrane transporter activity
SPNA45_RS00700	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPNA45_RS00705	COG5002	protein histidine kinase activity
SPNA45_RS00710	COG0745	RESPONSE REGULATOR receiver
SPNA45_RS00730	COG1438	arginine binding
SPNA45_RS00740	COG1132	(ABC) transporter
SPNA45_RS00745	COG1132	(ABC) transporter
SPNA45_RS00750	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPNA45_RS00765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SPNA45_RS00855	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SPNA45_RS00870	COG0582	viral genome integration into host DNA
SPNA45_RS00935	COG0534	Mate efflux family protein
SPNA45_RS00955	COG3759	membrane
SPNA45_RS00965	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SPNA45_RS00990	COG1063	alcohol dehydrogenase
SPNA45_RS01000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPNA45_RS01005	COG1459	type II secretion system
SPNA45_RS01010	COG4537	Required for transformation and DNA binding
SPNA45_RS01065	COG0706	membrane insertase activity
SPNA45_RS01070	COG1847	R3H domain protein
SPNA45_RS01080	COG3037	sugar-specific permease SgaT UlaA
SPNA45_RS01090	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPNA45_RS01100	COG3623	hexulose-6-phosphate isomerase
SPNA45_RS01120	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SPNA45_RS01130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPNA45_RS01140	COG1012	belongs to the aldehyde dehydrogenase family
SPNA45_RS01140	COG1454	alcohol dehydrogenase
SPNA45_RS01145	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPNA45_RS01155	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPNA45_RS01160	COG2723	6-phospho-beta-galactosidase activity
SPNA45_RS01165	COG2188	Transcriptional regulator
SPNA45_RS01170	COG4133	protoheme IX ABC transporter activity
SPNA45_RS01180	COG0157	Belongs to the NadC ModD family
SPNA45_RS01200	COG0577	efflux transmembrane transporter activity
SPNA45_RS01210	COG0564	pseudouridine synthase activity
SPNA45_RS01215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPNA45_RS01220	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPNA45_RS01330	COG1131	(ABC) transporter
SPNA45_RS01335	COG0842	Transport permease protein
SPNA45_RS01340	COG4585	Histidine kinase
SPNA45_RS01345	COG2197	response regulator
SPNA45_RS01350	COG1609	Transcriptional regulator
SPNA45_RS01360	COG0252	asparaginase activity
SPNA45_RS01365	COG0561	phosphatase activity
SPNA45_RS01370	COG0589	response to stress
SPNA45_RS01380	COG0436	Aminotransferase
SPNA45_RS01395	COG0084	hydrolase, TatD family'
SPNA45_RS01400	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SPNA45_RS01415	COG0577	efflux transmembrane transporter activity
SPNA45_RS01415	COG1136	(ABC) transporter
SPNA45_RS01430	COG1162	GTPase activity
SPNA45_RS01440	COG1564	THIamine pyrophosphokinase
SPNA45_RS01455	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPNA45_RS01465	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPNA45_RS01475	COG1254	Belongs to the acylphosphatase family
SPNA45_RS01480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPNA45_RS01495	COG0742	ribosomal rna small subunit methyltransferase
SPNA45_RS01505	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPNA45_RS01510	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPNA45_RS01525	COG1253	flavin adenine dinucleotide binding
SPNA45_RS01560	COG0577	efflux transmembrane transporter activity
SPNA45_RS01560	COG1136	(ABC) transporter
SPNA45_RS01585	COG0802	atpase or kinase
SPNA45_RS01595	COG1316	TRANSCRIPTIONal
SPNA45_RS01640	COG1132	(ABC) transporter
SPNA45_RS01675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPNA45_RS01680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPNA45_RS01685	COG4221	oxidoreductase activity
SPNA45_RS01780	COG0629	single-stranded DNA binding
SPNA45_RS01840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SPNA45_RS01945	COG5263	repeat protein
SPNA45_RS01945	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPNA45_RS01995	COG3231	kanamycin kinase activity
SPNA45_RS02000	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPNA45_RS02125	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPNA45_RS02125	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPNA45_RS02130	COG2207	Transcriptional regulator
SPNA45_RS02135	COG3345	alpha-galactosidase
SPNA45_RS02140	COG1653	transport
SPNA45_RS02150	COG0395	ABC-type sugar transport system, permease component
SPNA45_RS02155	COG0366	Alpha amylase catalytic
SPNA45_RS02170	COG4166	transmembrane transport
SPNA45_RS02180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPNA45_RS02185	COG0444	Belongs to the ABC transporter superfamily
SPNA45_RS02190	COG4608	Belongs to the ABC transporter superfamily
SPNA45_RS02200	COG4120	Belongs to the binding-protein-dependent transport system permease family
SPNA45_RS02210	COG2188	Transcriptional regulator
SPNA45_RS02215	COG1263	PTS System
SPNA45_RS02215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPNA45_RS02220	COG0366	Alpha amylase catalytic
SPNA45_RS02235	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SPNA45_RS02245	COG0517	IMP dehydrogenase activity
SPNA45_RS02265	COG1187	pseudouridine synthase activity
SPNA45_RS02275	COG4607	ABC-type enterochelin transport system periplasmic component
SPNA45_RS02280	COG4604	ABC transporter, ATP-binding protein
SPNA45_RS02285	COG4605	iron ion homeostasis
SPNA45_RS02290	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPNA45_RS02305	COG1363	Peptidase, m42
SPNA45_RS02330	COG1174	glycine betaine transport
SPNA45_RS02335	COG3201	nicotinamide mononucleotide transporter
SPNA45_RS02345	COG1230	cation diffusion facilitator family transporter
SPNA45_RS02350	COG0789	Transcriptional regulator
SPNA45_RS02360	COG1609	Transcriptional regulator
SPNA45_RS02365	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPNA45_RS02390	COG2233	PERMEase
SPNA45_RS02410	COG0708	Exodeoxyribonuclease III
SPNA45_RS02435	COG1132	(ABC) transporter
SPNA45_RS02440	COG1132	(ABC) transporter
SPNA45_RS02445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPNA45_RS02450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SPNA45_RS02480	COG0704	Plays a role in the regulation of phosphate uptake
SPNA45_RS02485	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPNA45_RS02510	COG1178	ABC-type Fe3 transport system permease component
SPNA45_RS02515	COG1285	pathogenesis
SPNA45_RS02540	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPNA45_RS02545	COG0512	Glutamine amidotransferase of anthranilate synthase
SPNA45_RS02595	COG1846	Transcriptional regulator
SPNA45_RS02595	COG1940	carbohydrate kinase activity
SPNA45_RS02610	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPNA45_RS02615	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPNA45_RS02620	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPNA45_RS02630	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPNA45_RS02655	COG3237	CsbD-like
SPNA45_RS02680	COG3711	transcriptional antiterminator
SPNA45_RS02690	COG4209	transmembrane transport
SPNA45_RS02695	COG0395	ABC-type sugar transport system, permease component
SPNA45_RS02700	COG1653	transport
SPNA45_RS02705	COG1621	beta-fructofuranosidase activity
SPNA45_RS02755	COG0582	viral genome integration into host DNA
SPNA45_RS02765	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPNA45_RS02800	COG1051	belongs to the nudix hydrolase family
SPNA45_RS02815	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPNA45_RS02820	COG1164	Oligoendopeptidase f
SPNA45_RS02825	COG0640	Transcriptional regulator
SPNA45_RS02835	COG1131	(ABC) transporter
SPNA45_RS02850	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPNA45_RS02860	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SPNA45_RS02865	COG3118	belongs to the thioredoxin family
SPNA45_RS02890	COG0668	transmembrane transport
SPNA45_RS02905	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPNA45_RS02910	COG1534	Rna-binding protein
SPNA45_RS02915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SPNA45_RS02920	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPNA45_RS02930	COG0799	negative regulation of ribosome biogenesis
SPNA45_RS02935	COG2226	methyltransferase
SPNA45_RS02955	COG0194	GDP metabolic process
SPNA45_RS02965	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPNA45_RS02975	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPNA45_RS02975	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPNA45_RS02980	COG0631	protein serine/threonine phosphatase activity
SPNA45_RS02985	COG0515	serine threonine protein kinase
SPNA45_RS02985	COG2815	serine threonine protein kinase
SPNA45_RS03015	COG3425	synthase
SPNA45_RS03025	COG1609	Transcriptional regulator
SPNA45_RS03030	COG1621	beta-fructofuranosidase activity
SPNA45_RS03040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPNA45_RS03040	COG2190	(PTS) system
SPNA45_RS03040	COG1263	PTS System
SPNA45_RS03045	COG1940	carbohydrate kinase activity
SPNA45_RS03060	COG4152	abc transporter atp-binding protein
SPNA45_RS03065	COG1668	transmembrane transport
SPNA45_RS03075	COG1131	(ABC) transporter
SPNA45_RS03080	COG1725	Transcriptional regulator
SPNA45_RS03095	COG1484	DNA-dependent DNA replication
SPNA45_RS03100	COG0778	Nitroreductase
SPNA45_RS03130	COG1131	(ABC) transporter
SPNA45_RS03140	COG0653	protein targeting
SPNA45_RS03145	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPNA45_RS03150	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPNA45_RS03165	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPNA45_RS03175	COG3458	cephalosporin-C deacetylase activity
SPNA45_RS03195	COG1653	transport
SPNA45_RS03200	COG1175	transmembrane transport
SPNA45_RS03210	COG4409	exo-alpha-(2->6)-sialidase activity
SPNA45_RS03215	COG0673	inositol 2-dehydrogenase activity
SPNA45_RS03225	COG2190	(PTS) system
SPNA45_RS03225	COG1263	PTS System
SPNA45_RS03225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPNA45_RS03235	COG1175	transmembrane transport
SPNA45_RS03240	COG0395	ABC-type sugar transport system, permease component
SPNA45_RS03245	COG2731	YhcH YjgK YiaL family protein
SPNA45_RS03260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPNA45_RS03275	COG0768	penicillin binding
SPNA45_RS03290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPNA45_RS03295	COG1051	belongs to the nudix hydrolase family
SPNA45_RS03315	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPNA45_RS03335	COG3599	regulation of cell shape
SPNA45_RS03385	COG0577	efflux transmembrane transporter activity
SPNA45_RS03385	COG1136	(ABC) transporter
SPNA45_RS03395	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SPNA45_RS03400	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPNA45_RS03415	COG3590	peptidase
SPNA45_RS03470	COG1959	2 iron, 2 sulfur cluster binding
SPNA45_RS03485	COG0745	RESPONSE REGULATOR receiver
SPNA45_RS03490	COG5002	protein histidine kinase activity
SPNA45_RS03510	COG2910	NAD(P)H-binding
SPNA45_RS03525	COG0204	Acyl-transferase
SPNA45_RS03530	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SPNA45_RS03540	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SPNA45_RS03550	COG2801	Transposase and inactivated derivatives
SPNA45_RS03570	COG2384	SAM-dependent methyltransferase
SPNA45_RS03575	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SPNA45_RS03580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPNA45_RS03590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPNA45_RS03595	COG0463	Glycosyl transferase, family 2
SPNA45_RS03615	COG2824	Alkylphosphonate utilization operon protein PhnA
SPNA45_RS03640	COG0351	phosphomethylpyrimidine kinase
SPNA45_RS03645	COG4720	Psort location CytoplasmicMembrane, score
SPNA45_RS03655	COG2801	Transposase and inactivated derivatives
SPNA45_RS03660	COG0006	proline dipeptidase activity
SPNA45_RS03665	COG3442	glutamine amidotransferase
SPNA45_RS03670	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPNA45_RS03675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPNA45_RS03680	COG2223	nitrite transmembrane transporter activity
SPNA45_RS03685	COG0513	Belongs to the DEAD box helicase family
SPNA45_RS03705	COG3842	ATPase activity
SPNA45_RS03715	COG2226	methyltransferase
SPNA45_RS03730	COG3935	DnaD domain protein
SPNA45_RS03750	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPNA45_RS03770	COG0251	oxidation-reduction process
SPNA45_RS03780	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SPNA45_RS03800	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPNA45_RS03830	COG0617	tRNA 3'-terminal CCA addition
SPNA45_RS03835	COG0488	(ABC) transporter
SPNA45_RS03840	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPNA45_RS03850	COG0625	glutathione transferase activity
SPNA45_RS03855	COG0242	peptide deformylase activity
SPNA45_RS03890	COG0436	Aminotransferase
SPNA45_RS03900	COG0017	Asparaginyl-tRNA synthetase
SPNA45_RS03910	COG0629	single-stranded DNA binding
SPNA45_RS03915	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPNA45_RS03925	COG1098	S1 RNA binding domain
SPNA45_RS03930	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPNA45_RS03935	COG2827	Endonuclease containing a URI domain
SPNA45_RS03960	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPNA45_RS03965	COG2244	polysaccharide biosynthetic process
SPNA45_RS03970	COG4166	transmembrane transport
SPNA45_RS03975	COG1132	(ABC) transporter
SPNA45_RS03980	COG1132	(ABC) transporter
SPNA45_RS03985	COG0626	cystathionine gamma-synthase activity
SPNA45_RS03990	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SPNA45_RS03995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPNA45_RS04020	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPNA45_RS04100	COG2706	6-phosphogluconolactonase activity
SPNA45_RS04105	COG0628	permease
SPNA45_RS04120	COG1126	abc transporter atp-binding protein
SPNA45_RS04125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPNA45_RS04135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPNA45_RS04175	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPNA45_RS04210	COG0726	polysaccharide deacetylase
SPNA45_RS04215	COG0656	L-ascorbic acid biosynthetic process
SPNA45_RS04240	COG3976	FMN-binding domain protein
SPNA45_RS04240	COG1053	succinate dehydrogenase
SPNA45_RS04240	COG0431	NADPH-dependent FMN reductase
SPNA45_RS04270	COG1272	protein, Hemolysin III
SPNA45_RS04285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SPNA45_RS04290	COG1393	Belongs to the ArsC family
SPNA45_RS04300	COG1126	abc transporter atp-binding protein
SPNA45_RS04310	COG0492	ferredoxin-NADP+ reductase activity
SPNA45_RS04345	COG0561	phosphatase activity
SPNA45_RS04360	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPNA45_RS04365	COG0697	spore germination
SPNA45_RS04370	COG2188	Transcriptional regulator
SPNA45_RS04410	COG1129	ABC transporter
SPNA45_RS04425	COG1132	(ABC) transporter
SPNA45_RS04455	COG0826	peptidase U32
SPNA45_RS04470	COG1131	(ABC) transporter
SPNA45_RS04495	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPNA45_RS04555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPNA45_RS04565	COG0647	UMP catabolic process
SPNA45_RS04575	COG1393	Belongs to the ArsC family
SPNA45_RS04585	COG0483	inositol monophosphate 1-phosphatase activity
SPNA45_RS04590	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPNA45_RS04590	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPNA45_RS04595	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPNA45_RS04600	COG0573	inorganic phosphate transmembrane transporter activity
SPNA45_RS04605	COG0581	inorganic phosphate transmembrane transporter activity
SPNA45_RS04610	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPNA45_RS04615	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPNA45_RS04620	COG0704	Plays a role in the regulation of phosphate uptake
SPNA45_RS04625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPNA45_RS04630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPNA45_RS04635	COG3527	Alpha-acetolactate decarboxylase
SPNA45_RS04650	COG3842	ATPase activity
SPNA45_RS04690	COG1131	(ABC) transporter
SPNA45_RS04700	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPNA45_RS04725	COG0287	Prephenate dehydrogenase
SPNA45_RS04740	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SPNA45_RS04745	COG0077	Prephenate dehydratase
SPNA45_RS04755	COG3475	LICD family
SPNA45_RS04765	COG1215	transferase activity, transferring glycosyl groups
SPNA45_RS04800	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPNA45_RS04800	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPNA45_RS04805	COG1132	(ABC) transporter
SPNA45_RS04820	COG0402	S-adenosylhomocysteine deaminase activity
SPNA45_RS04835	COG0582	viral genome integration into host DNA
SPNA45_RS04920	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPNA45_RS04970	COG3335	DDE superfamily endonuclease
SPNA45_RS04980	COG4372	Transposase
SPNA45_RS05010	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPNA45_RS05020	COG2837	iron assimilation
SPNA45_RS05035	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPNA45_RS05040	COG0716	FMN binding
SPNA45_RS05045	COG1605	Chorismate mutase
SPNA45_RS05045	COG0077	Prephenate dehydratase
SPNA45_RS05050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPNA45_RS05055	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPNA45_RS05080	COG1078	dGTPase activity
SPNA45_RS05095	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPNA45_RS05110	COG1704	LemA family
SPNA45_RS05130	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPNA45_RS05145	COG0505	Belongs to the CarA family
SPNA45_RS05155	COG3475	LICD family
SPNA45_RS05160	COG3475	LICD family
SPNA45_RS05175	COG1063	alcohol dehydrogenase
SPNA45_RS05190	COG4750	Nucleotidyl transferase
SPNA45_RS05195	COG0758	DNA mediated transformation
SPNA45_RS05205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPNA45_RS05210	COG2832	Protein of unknown function (DUF454)
SPNA45_RS05215	COG3142	Participates in the control of copper homeostasis
SPNA45_RS05230	COG0473	3-isopropylmalate dehydrogenase activity
SPNA45_RS05240	COG0066	3-isopropylmalate dehydratase activity
SPNA45_RS05280	COG1196	nuclear chromosome segregation
SPNA45_RS05320	COG0561	phosphatase activity
SPNA45_RS05325	COG0561	phosphatase activity
SPNA45_RS05330	COG0552	protein localization to endoplasmic reticulum
SPNA45_RS05335	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPNA45_RS05340	COG1126	abc transporter atp-binding protein
SPNA45_RS05345	COG0765	amino acid transport
SPNA45_RS05375	COG1827	regulation of RNA biosynthetic process
SPNA45_RS05385	COG4684	Psort location CytoplasmicMembrane, score
SPNA45_RS05390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPNA45_RS05405	COG1194	a g-specific adenine glycosylase
SPNA45_RS05410	COG0745	RESPONSE REGULATOR receiver
SPNA45_RS05415	COG5002	protein histidine kinase activity
SPNA45_RS05420	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPNA45_RS05450	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPNA45_RS05455	COG3764	Sortase (surface protein transpeptidase)
SPNA45_RS05475	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SPNA45_RS05495	COG1570	exodeoxyribonuclease VII activity
SPNA45_RS05510	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPNA45_RS05515	COG1438	arginine binding
SPNA45_RS05520	COG0497	DNA recombination
SPNA45_RS05525	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SPNA45_RS05550	COG3775	system Galactitol-specific IIC component
SPNA45_RS05560	COG3250	beta-galactosidase activity
SPNA45_RS05580	COG1242	4 iron, 4 sulfur cluster binding
SPNA45_RS05585	COG1242	4 iron, 4 sulfur cluster binding
SPNA45_RS05590	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPNA45_RS05615	COG0785	Cytochrome C biogenesis protein
SPNA45_RS05620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPNA45_RS05625	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPNA45_RS05625	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPNA45_RS05630	COG4753	response regulator
SPNA45_RS05630	COG2207	Transcriptional regulator
SPNA45_RS05635	COG2972	Histidine kinase
SPNA45_RS05650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPNA45_RS05665	COG1940	carbohydrate kinase activity
SPNA45_RS05685	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPNA45_RS05690	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPNA45_RS05700	COG0300	oxidoreductase activity
SPNA45_RS05715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPNA45_RS05725	COG1187	pseudouridine synthase activity
SPNA45_RS05730	COG1217	gtp-binding protein TYPA
SPNA45_RS05750	COG1136	(ABC) transporter
SPNA45_RS05765	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SPNA45_RS05800	COG2826	transposase and inactivated derivatives, IS30 family
SPNA45_RS05805	COG0284	orotidine-5'-phosphate decarboxylase activity
SPNA45_RS05810	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SPNA45_RS05835	COG1131	(ABC) transporter
SPNA45_RS05840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPNA45_RS05845	COG1126	abc transporter atp-binding protein
SPNA45_RS05850	COG1129	ABC transporter
SPNA45_RS05855	COG4215	(ABC) transporter
SPNA45_RS05865	COG1304	FMN binding
SPNA45_RS05875	COG1304	FMN binding
SPNA45_RS05890	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SPNA45_RS05895	COG0352	thiamine-phosphate diphosphorylase activity
SPNA45_RS05915	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SPNA45_RS05930	COG0352	thiamine-phosphate diphosphorylase activity
SPNA45_RS05950	COG2217	Heavy metal translocating P-type atpase
SPNA45_RS05955	COG0028	Belongs to the TPP enzyme family
SPNA45_RS05965	COG3335	DDE superfamily endonuclease
SPNA45_RS05985	COG2723	6-phospho-beta-galactosidase activity
SPNA45_RS05990	COG1482	cell wall glycoprotein biosynthetic process
SPNA45_RS06010	COG2081	HI0933 family
SPNA45_RS06015	COG1307	EDD domain protein, DegV family
SPNA45_RS06025	COG2131	deaminase
SPNA45_RS06030	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SPNA45_RS06075	COG0517	IMP dehydrogenase activity
SPNA45_RS06075	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPNA45_RS06075	COG0617	tRNA 3'-terminal CCA addition
SPNA45_RS06080	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SPNA45_RS06085	COG2884	Cell division ATP-binding protein ftsE
SPNA45_RS06090	COG2177	Part of the ABC transporter FtsEX involved in
SPNA45_RS06095	COG1263	PTS System
SPNA45_RS06095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPNA45_RS06095	COG2190	(PTS) system
SPNA45_RS06105	COG0513	Belongs to the DEAD box helicase family
SPNA45_RS06115	COG0167	dihydroorotate dehydrogenase activity
SPNA45_RS06125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SPNA45_RS06130	COG4470	Protein conserved in bacteria
SPNA45_RS06145	COG0488	(ABC) transporter
SPNA45_RS06170	COG1837	Belongs to the UPF0109 family
SPNA45_RS06195	COG1328	CTP reductase activity
SPNA45_RS06195	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPNA45_RS06205	COG4443	Transcriptional Coactivator p15 (PC4)
SPNA45_RS06215	COG1268	BioY protein
SPNA45_RS06225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPNA45_RS06230	COG1136	(ABC) transporter
SPNA45_RS06235	COG0577	efflux transmembrane transporter activity
SPNA45_RS06240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPNA45_RS06240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPNA45_RS06260	COG4989	oxidoreductase activity
SPNA45_RS06270	COG1028	Short-chain dehydrogenase reductase Sdr
SPNA45_RS06295	COG0745	RESPONSE REGULATOR receiver
SPNA45_RS06300	COG5002	protein histidine kinase activity
SPNA45_RS06320	COG0772	Belongs to the SEDS family
SPNA45_RS06325	COG0693	protein deglycase activity
SPNA45_RS06335	COG0187	DNA topoisomerase II activity
SPNA45_RS06355	COG2801	Transposase and inactivated derivatives
SPNA45_RS06370	COG0494	nUDIX hydrolase
SPNA45_RS06390	COG0542	response to heat
SPNA45_RS06395	COG4703	Protein of unknown function (DUF1797)
SPNA45_RS06400	COG0765	amino acid transport
SPNA45_RS06405	COG1126	abc transporter atp-binding protein
SPNA45_RS06410	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPNA45_RS06415	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SPNA45_RS06435	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SPNA45_RS06480	COG2813	Specifically methylates the guanine in position
SPNA45_RS06485	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SPNA45_RS06495	COG0295	cytidine deaminase activity
SPNA45_RS06500	COG1744	ABC transporter substrate-binding protein PnrA-like
SPNA45_RS06505	COG3845	ABC transporter
SPNA45_RS06510	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPNA45_RS06515	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPNA45_RS06535	COG0187	DNA topoisomerase II activity
SPNA45_RS06545	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPNA45_RS06550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPNA45_RS06555	COG4166	transmembrane transport
SPNA45_RS06590	COG0539	negative regulation of cytoplasmic translation
SPNA45_RS06610	COG1956	GAF domain-containing protein
SPNA45_RS06615	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPNA45_RS06630	COG0719	Fe-S assembly protein
SPNA45_RS06635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPNA45_RS06645	COG0719	Fe-S assembly protein
SPNA45_RS06655	COG1686	Belongs to the peptidase S11 family
SPNA45_RS06660	COG0628	permease
SPNA45_RS06670	COG1349	DNA-binding transcription factor activity
SPNA45_RS06675	COG1105	Belongs to the carbohydrate kinase PfkB family
SPNA45_RS06680	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPNA45_RS06680	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPNA45_RS06680	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPNA45_RS06685	COG0697	spore germination
SPNA45_RS06685	COG1674	ftsk spoiiie
SPNA45_RS06695	COG1104	cysteine desulfurase activity
SPNA45_RS06755	COG1438	arginine binding
SPNA45_RS06775	COG0469	pyruvate kinase activity
SPNA45_RS06780	COG0582	viral genome integration into host DNA
SPNA45_RS06815	COG3689	TIGRFAM TIGR03943 family protein
SPNA45_RS06820	COG0701	Predicted permease
SPNA45_RS06830	COG2183	response to ionizing radiation
SPNA45_RS06855	COG1136	(ABC) transporter
SPNA45_RS06860	COG0577	efflux transmembrane transporter activity
SPNA45_RS06880	COG1982	Orn Lys Arg decarboxylase major
SPNA45_RS06895	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SPNA45_RS06915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPNA45_RS06930	COG0561	phosphatase activity
SPNA45_RS06950	COG0583	DNA-binding transcription factor activity
SPNA45_RS06955	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPNA45_RS06960	COG0564	pseudouridine synthase activity
SPNA45_RS06965	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPNA45_RS06980	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPNA45_RS06990	COG0470	DNA polymerase III
SPNA45_RS07035	COG0528	UMP kinase activity
SPNA45_RS07045	COG2996	Protein conserved in bacteria
SPNA45_RS07055	COG1702	phosphate starvation-inducible protein PhoH
SPNA45_RS07070	COG0686	Belongs to the AlaDH PNT family
SPNA45_RS07075	COG0686	Belongs to the AlaDH PNT family
SPNA45_RS07080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPNA45_RS07085	COG1596	polysaccharide export
SPNA45_RS07085	COG1555	photosystem II stabilization
SPNA45_RS07100	COG1131	(ABC) transporter
SPNA45_RS07130	COG0543	2 iron, 2 sulfur cluster binding
SPNA45_RS07135	COG0167	dihydroorotate dehydrogenase activity
SPNA45_RS07140	COG4193	domain, Protein
SPNA45_RS07140	COG5263	repeat protein
SPNA45_RS07145	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPNA45_RS07155	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPNA45_RS07165	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPNA45_RS07170	COG0237	dephospho-CoA kinase activity
SPNA45_RS07175	COG2814	Major facilitator Superfamily
SPNA45_RS07180	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPNA45_RS07190	COG0557	exoribonuclease II activity
SPNA45_RS07200	COG3615	Tellurite resistance protein tehB
SPNA45_RS07200	COG0500	methyltransferase
SPNA45_RS07215	COG4122	O-methyltransferase activity
SPNA45_RS07225	COG2801	Transposase and inactivated derivatives
SPNA45_RS07240	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SPNA45_RS07260	COG0494	nUDIX hydrolase
SPNA45_RS07270	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPNA45_RS07280	COG2176	DNA-directed DNA polymerase activity
SPNA45_RS07285	COG0584	glycerophosphoryl diester phosphodiesterase
SPNA45_RS07310	COG0785	Cytochrome C biogenesis protein
SPNA45_RS07315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPNA45_RS07320	COG0531	amino acid
SPNA45_RS07325	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPNA45_RS07325	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPNA45_RS07355	COG2195	Cleaves the N-terminal amino acid of tripeptides
SPNA45_RS07360	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SPNA45_RS07375	COG4708	membrane
SPNA45_RS07385	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPNA45_RS07400	COG1942	4-Oxalocrotonate Tautomerase
SPNA45_RS07415	COG2890	protein-(glutamine-N5) methyltransferase activity
SPNA45_RS07440	COG0741	lytic transglycosylase activity
SPNA45_RS07450	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPNA45_RS07475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPNA45_RS07480	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPNA45_RS07555	COG1597	lipid kinase activity
SPNA45_RS07560	COG0366	Alpha amylase catalytic
SPNA45_RS07575	COG1396	sequence-specific DNA binding
SPNA45_RS07580	COG0542	response to heat
SPNA45_RS07585	COG0613	PHP domain protein
SPNA45_RS07590	COG0613	PHP domain protein
SPNA45_RS07595	COG1196	nuclear chromosome segregation
SPNA45_RS07610	COG3843	relaxase mobilization nuclease domain protein
SPNA45_RS07645	COG1131	(ABC) transporter
SPNA45_RS07655	COG1396	sequence-specific DNA binding
SPNA45_RS07660	COG0772	Belongs to the SEDS family
SPNA45_RS07665	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SPNA45_RS07685	COG0358	DNA primase activity
SPNA45_RS07690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPNA45_RS07695	COG2151	metal-sulfur cluster biosynthetic enzyme
SPNA45_RS07700	COG0438	transferase activity, transferring glycosyl groups
SPNA45_RS07705	COG0438	transferase activity, transferring glycosyl groups
SPNA45_RS07730	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPNA45_RS07740	COG4109	DRTGG domain
SPNA45_RS07745	COG0024	Methionine aminopeptidase
SPNA45_RS07760	COG0210	DNA helicase
SPNA45_RS07770	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPNA45_RS07790	COG1104	cysteine desulfurase activity
SPNA45_RS07795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPNA45_RS07805	COG2357	RelA SpoT domain protein
SPNA45_RS07815	COG0564	pseudouridine synthase activity
SPNA45_RS07820	COG0280	phosphate acetyltransferase
SPNA45_RS07870	COG0196	riboflavin kinase activity
SPNA45_RS07875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPNA45_RS07880	COG1307	EDD domain protein, DegV family
SPNA45_RS07885	COG0776	regulation of translation
SPNA45_RS07890	COG0488	(ABC) transporter
SPNA45_RS07910	COG1523	belongs to the glycosyl hydrolase 13 family
SPNA45_RS07920	COG1012	belongs to the aldehyde dehydrogenase family
SPNA45_RS07925	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SPNA45_RS07935	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SPNA45_RS07945	COG0560	Phosphoserine phosphatase
SPNA45_RS07950	COG0560	Phosphoserine phosphatase
SPNA45_RS08000	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPNA45_RS08005	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SPNA45_RS08020	COG0095	Lipoate-protein ligase
SPNA45_RS08025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPNA45_RS08030	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPNA45_RS08035	COG0022	dehydrogenase e1 component
SPNA45_RS08040	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPNA45_RS08045	COG0534	Mate efflux family protein
SPNA45_RS08055	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPNA45_RS08060	COG1051	belongs to the nudix hydrolase family
SPNA45_RS08075	COG1011	Hydrolase
SPNA45_RS08080	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SPNA45_RS08095	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPNA45_RS08100	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPNA45_RS08105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPNA45_RS08110	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPNA45_RS08125	COG2723	6-phospho-beta-galactosidase activity
SPNA45_RS08140	COG3711	transcriptional antiterminator
SPNA45_RS08145	COG3684	Belongs to the aldolase LacD family
SPNA45_RS08195	COG4372	Transposase
SPNA45_RS08255	COG4555	ABC transporter
SPNA45_RS08305	COG1363	Peptidase, m42
SPNA45_RS08310	COG1114	Component of the transport system for branched-chain amino acids
SPNA45_RS08320	COG1573	uracil-dna glycosylase
SPNA45_RS08375	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPNA45_RS08375	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPNA45_RS08385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPNA45_RS08390	COG0765	amino acid transport
SPNA45_RS08395	COG0765	amino acid transport
SPNA45_RS08400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SPNA45_RS08405	COG0191	fructose-bisphosphate aldolase activity
SPNA45_RS08410	COG5002	protein histidine kinase activity
SPNA45_RS08415	COG0745	RESPONSE REGULATOR receiver
SPNA45_RS08420	COG0577	efflux transmembrane transporter activity
SPNA45_RS08425	COG1136	(ABC) transporter
SPNA45_RS08430	COG0577	efflux transmembrane transporter activity
SPNA45_RS08450	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPNA45_RS08455	COG0215	cysteine-tRNA ligase activity
SPNA45_RS08465	COG1045	serine acetyltransferase
SPNA45_RS08485	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SPNA45_RS08490	COG3620	sequence-specific DNA binding
SPNA45_RS08530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPNA45_RS08530	COG0072	phenylalanine-tRNA ligase activity
SPNA45_RS08535	COG0456	acetyltransferase
SPNA45_RS08550	COG2190	(PTS) system
SPNA45_RS08550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPNA45_RS08550	COG1263	PTS System
SPNA45_RS08555	COG3711	transcriptional antiterminator
SPNA45_RS08580	COG2801	Transposase and inactivated derivatives
SPNA45_RS08595	COG0525	valine-tRNA ligase activity
SPNA45_RS08605	COG0519	Catalyzes the synthesis of GMP from XMP
SPNA45_RS08655	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SPNA45_RS08670	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPNA45_RS08675	COG0195	Participates in both transcription termination and antitermination
SPNA45_RS08695	COG1266	CAAX protease self-immunity
SPNA45_RS08725	COG2274	protein secretion by the type I secretion system
SPNA45_RS08730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPNA45_RS08765	COG1131	(ABC) transporter
SPNA45_RS08770	COG0537	adenosine 5'-monophosphoramidase activity
SPNA45_RS08780	COG0484	heat shock protein binding
SPNA45_RS08820	COG0174	glutamine synthetase
SPNA45_RS08825	COG0789	Transcriptional regulator
SPNA45_RS08845	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPNA45_RS08850	COG0504	CTP synthase activity
SPNA45_RS08865	COG1247	-acetyltransferase
SPNA45_RS08875	COG0671	phosphoesterase, PA-phosphatase related
SPNA45_RS08880	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPNA45_RS08895	COG1122	ATPase activity
SPNA45_RS08915	COG0569	domain protein
SPNA45_RS08920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPNA45_RS08955	COG1882	Formate acetyltransferase
SPNA45_RS08960	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPNA45_RS08990	COG0765	amino acid transport
SPNA45_RS09005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SPNA45_RS09025	COG0440	acetolactate synthase activity
SPNA45_RS09030	COG0028	Belongs to the TPP enzyme family
SPNA45_RS09035	COG1461	Dihydroxyacetone kinase
SPNA45_RS09045	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SPNA45_RS09105	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPNA45_RS09110	COG0439	Biotin carboxylase
SPNA45_RS09125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPNA45_RS09130	COG1028	Short-chain dehydrogenase reductase Sdr
SPNA45_RS09135	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPNA45_RS09145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPNA45_RS09155	COG1846	Transcriptional regulator
SPNA45_RS09160	COG1024	Enoyl-CoA hydratase
SPNA45_RS09165	COG0527	aspartate kinase activity
SPNA45_RS09190	COG1115	amino acid carrier protein
SPNA45_RS09215	COG0681	Belongs to the peptidase S26 family
SPNA45_RS09220	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPNA45_RS09245	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPNA45_RS09255	COG2213	PTS system mannitol-specific
SPNA45_RS09270	COG2801	Transposase and inactivated derivatives
SPNA45_RS09275	COG2801	Transposase and inactivated derivatives
SPNA45_RS09310	COG2197	response regulator
SPNA45_RS09315	COG4585	Histidine kinase
SPNA45_RS09370	COG0745	RESPONSE REGULATOR receiver
SPNA45_RS09375	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SPNA45_RS09385	COG0116	Belongs to the methyltransferase superfamily
SPNA45_RS09410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPNA45_RS09415	COG0366	Alpha amylase catalytic
SPNA45_RS09420	COG4166	transmembrane transport
SPNA45_RS09430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPNA45_RS09490	COG4166	transmembrane transport
SPNA45_RS09495	COG0366	Alpha amylase catalytic
SPNA45_RS09510	COG3344	reverse transcriptase
SPNA45_RS09525	COG0768	penicillin binding
SPNA45_RS09530	COG4839	cell division protein FtsL
SPNA45_RS09560	COG1609	Transcriptional regulator
SPNA45_RS09575	COG3716	PTS system mannose fructose sorbose family IID component
SPNA45_RS09580	COG3715	PTS system
SPNA45_RS09585	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPNA45_RS09590	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SPNA45_RS09600	COG1028	Short-chain dehydrogenase reductase Sdr
SPNA45_RS09625	COG5492	domain, Protein
SPNA45_RS09630	COG0386	Belongs to the glutathione peroxidase family
SPNA45_RS09645	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPNA45_RS09675	COG2723	6-phospho-beta-galactosidase activity
SPNA45_RS09700	COG1674	ftsk spoiiie
SPNA45_RS09715	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SPNA45_RS09740	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPNA45_RS09750	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SPNA45_RS09750	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPNA45_RS09760	COG0285	dihydrofolate synthase activity
SPNA45_RS09765	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SPNA45_RS09775	COG2252	PERMEase
SPNA45_RS09780	COG0561	phosphatase activity
SPNA45_RS09785	COG1064	alcohol dehydrogenase
SPNA45_RS09795	COG3715	PTS system
SPNA45_RS09800	COG3716	PTS system mannose fructose sorbose family IID component
SPNA45_RS09805	COG3579	cysteine-type endopeptidase activity
SPNA45_RS09815	COG1187	pseudouridine synthase activity
SPNA45_RS09820	COG2261	transglycosylase associated protein
SPNA45_RS09825	COG2309	aminopeptidase activity
SPNA45_RS09845	COG2176	DNA-directed DNA polymerase activity
SPNA45_RS09865	COG1523	belongs to the glycosyl hydrolase 13 family
SPNA45_RS09875	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPNA45_RS09880	COG2723	6-phospho-beta-galactosidase activity
SPNA45_RS09890	COG0750	zinc metalloprotease
SPNA45_RS09895	COG4589	Belongs to the CDS family
SPNA45_RS09900	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPNA45_RS09950	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPNA45_RS09955	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPNA45_RS09960	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPNA45_RS09970	COG1349	DNA-binding transcription factor activity
SPNA45_RS09975	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPNA45_RS09995	COG3842	ATPase activity
SPNA45_RS10020	COG3830	Belongs to the UPF0237 family
SPNA45_RS10035	COG0202	RNA polymerase activity
SPNA45_RS10040	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SPNA45_RS10050	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SPNA45_RS10055	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SPNA45_RS10065	COG0201	protein transport
SPNA45_RS10080	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SPNA45_RS10120	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SPNA45_RS10145	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPNA45_RS10180	COG0602	queuosine metabolic process
SPNA45_RS10210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPNA45_RS10220	COG0285	dihydrofolate synthase activity
SPNA45_RS10245	COG1393	Belongs to the ArsC family
SPNA45_RS10250	COG0006	proline dipeptidase activity
SPNA45_RS10255	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPNA45_RS10280	COG2818	Glycosylase
SPNA45_RS10300	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPNA45_RS10300	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPNA45_RS10330	COG1780	Probably involved in ribonucleotide reductase function
SPNA45_RS10340	COG0582	viral genome integration into host DNA
SPNA45_RS10345	COG3645	SOS response
SPNA45_RS10455	COG4753	response regulator
SPNA45_RS10455	COG2207	Transcriptional regulator
SPNA45_RS10460	COG2972	Histidine kinase
SPNA45_RS10480	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPNA45_RS10485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPNA45_RS10490	COG1464	Belongs to the NlpA lipoprotein family
SPNA45_RS10495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPNA45_RS10530	COG1396	sequence-specific DNA binding
SPNA45_RS10600	COG1214	PFAM Peptidase M22, glycoprotease
SPNA45_RS10635	COG0445	tRNA wobble uridine modification
SPNA45_RS10640	COG0494	nUDIX hydrolase
SPNA45_RS10760	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPNA45_RS10760	COG1388	LysM domain
SPNA45_RS10765	COG1760	l-serine dehydratase
SPNA45_RS10770	COG1760	l-serine dehydratase
SPNA45_RS10775	COG0546	phosphoglycolate phosphatase activity
SPNA45_RS10800	COG1695	Transcriptional regulator
SPNA45_RS10825	COG1653	transport
SPNA45_RS10830	COG0395	ABC-type sugar transport system, permease component
SPNA45_RS10835	COG4209	transmembrane transport
SPNA45_RS10855	COG5002	protein histidine kinase activity
SPNA45_RS10875	COG1215	transferase activity, transferring glycosyl groups
SPNA45_RS10880	COG0569	domain protein
SPNA45_RS10885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPNA45_RS10915	COG2514	catechol 2,3-dioxygenase activity
SPNA45_RS10925	COG2222	sugar isomerase
SPNA45_RS10935	COG3716	PTS system mannose fructose sorbose family IID component
SPNA45_RS10940	COG3715	PTS system
SPNA45_RS10945	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPNA45_RS10960	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPNA45_RS10960	COG3583	domain protein
SPNA45_RS10960	COG3064	Membrane
SPNA45_RS10965	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPNA45_RS10980	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPNA45_RS10985	COG0151	Belongs to the GarS family
SPNA45_RS11000	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPNA45_RS11010	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SPNA45_RS11015	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPNA45_RS11030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPNA45_RS11035	COG2274	protein secretion by the type I secretion system
SPNA45_RS11075	COG0436	Aminotransferase
SPNA45_RS11080	COG2855	membrane
SPNA45_RS11090	COG1832	CoA-binding protein
SPNA45_RS11095	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPNA45_RS11095	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPNA45_RS11110	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPNA45_RS11125	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SPNA45_RS11135	COG0756	dUTP diphosphatase activity
SPNA45_RS11155	COG0549	Belongs to the carbamate kinase family
SPNA45_RS11160	COG1288	antiporter activity
SPNA45_RS11165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPNA45_RS11185	COG1454	alcohol dehydrogenase
SPNA45_RS11205	COG3716	PTS system mannose fructose sorbose family IID component
SPNA45_RS11215	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPNA45_RS11220	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPNA45_RS11235	COG1070	Carbohydrate kinase
SPNA45_RS11245	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPNA45_RS11245	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPNA45_RS11250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPNA45_RS11255	COG1121	(ABC) transporter
SPNA45_RS11260	COG1846	Transcriptional regulator
SPNA45_RS11265	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPNA45_RS11275	COG1696	Membrane protein involved in D-alanine export
SPNA45_RS11290	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPNA45_RS11295	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SPNA45_RS11315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPNA45_RS11355	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPNA45_RS11360	COG5002	protein histidine kinase activity
SPNA45_RS11365	COG0745	RESPONSE REGULATOR receiver
SPNA45_RS11370	COG0542	response to heat
SPNA45_RS11375	COG4463	regulation of RNA biosynthetic process
SPNA45_RS11380	COG1116	anion transmembrane transporter activity
SPNA45_RS11385	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SPNA45_RS11390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SPNA45_RS11410	COG0305	Participates in initiation and elongation during chromosome replication
SPNA45_RS11430	COG1040	competence protein
SPNA45_RS11435	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPNA45_RS11440	COG1739	Uncharacterized protein family UPF0029
SPNA45_RS11455	COG3335	DDE superfamily endonuclease
SPNA45_RS11475	COG3942	CHAP domain
SPNA45_RS11485	COG1792	Involved in formation and maintenance of cell shape
SPNA45_RS11490	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPNA45_RS11495	COG1122	ATPase activity
SPNA45_RS11500	COG1122	ATPase activity
SPNA45_RS11505	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPNA45_RS11515	COG0612	Peptidase, M16
SPNA45_RS11520	COG0612	Peptidase, M16
SPNA45_RS11525	COG2501	S4 domain
SPNA45_RS11535	COG0516	GMP reductase activity
SPNA45_RS11535	COG0517	IMP dehydrogenase activity
SPNA45_RS11540	COG0180	Tryptophanyl-tRNA synthetase
SPNA45_RS11545	COG0488	(ABC) transporter
SPNA45_RS11555	COG1511	domain protein
SPNA45_RS11560	COG1511	domain protein
SPNA45_RS11605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPNA45_RS11610	COG1475	DNA binding
SPNA45_RS11660	COG2274	protein secretion by the type I secretion system