locus-tag	class	description
C1H54_RS00010	COG0592	DNA-directed DNA polymerase activity
C1H54_RS00115	COG4974	Belongs to the 'phage' integrase family
C1H54_RS00120	COG0012	GTP binding
C1H54_RS00130	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C1H54_RS00135	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C1H54_RS00155	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C1H54_RS00160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1H54_RS00230	COG0756	dUTP diphosphatase activity
C1H54_RS00240	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C1H54_RS00255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C1H54_RS00280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1H54_RS00280	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1H54_RS00285	COG1832	CoA-binding protein
C1H54_RS00290	COG2855	membrane
C1H54_RS00295	COG0436	Aminotransferase
C1H54_RS00310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1H54_RS00350	COG1388	LysM domain
C1H54_RS00350	COG1134	teichoic acid transport
C1H54_RS00360	COG2274	protein secretion by the type I secretion system
C1H54_RS00365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1H54_RS00380	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1H54_RS00385	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C1H54_RS00395	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C1H54_RS00410	COG0151	Belongs to the GarS family
C1H54_RS00425	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C1H54_RS00440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1H54_RS00445	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1H54_RS00445	COG3064	Membrane
C1H54_RS00445	COG3583	domain protein
C1H54_RS00460	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1H54_RS00465	COG3715	PTS system
C1H54_RS00470	COG3716	PTS system mannose fructose sorbose family IID component
C1H54_RS00480	COG2222	sugar isomerase
C1H54_RS00490	COG2514	catechol 2,3-dioxygenase activity
C1H54_RS00495	COG1937	Protein conserved in bacteria
C1H54_RS00535	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1H54_RS00540	COG0569	domain protein
C1H54_RS00550	COG1215	transferase activity, transferring glycosyl groups
C1H54_RS00570	COG5002	protein histidine kinase activity
C1H54_RS00595	COG4209	transmembrane transport
C1H54_RS00600	COG0395	ABC-type sugar transport system, permease component
C1H54_RS00610	COG1653	transport
C1H54_RS00645	COG1695	Transcriptional regulator
C1H54_RS00670	COG0546	phosphoglycolate phosphatase activity
C1H54_RS00675	COG1760	l-serine dehydratase
C1H54_RS00680	COG1760	l-serine dehydratase
C1H54_RS00685	COG1388	LysM domain
C1H54_RS00685	COG1705	Flagellar rod assembly protein muramidase FlgJ
C1H54_RS00720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1H54_RS00725	COG0137	argininosuccinate synthase activity
C1H54_RS00740	COG2274	protein secretion by the type I secretion system
C1H54_RS00840	COG0494	nUDIX hydrolase
C1H54_RS00845	COG0445	tRNA wobble uridine modification
C1H54_RS00880	COG1214	PFAM Peptidase M22, glycoprotease
C1H54_RS00920	COG0438	transferase activity, transferring glycosyl groups
C1H54_RS00955	COG1396	sequence-specific DNA binding
C1H54_RS00985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1H54_RS00990	COG1464	Belongs to the NlpA lipoprotein family
C1H54_RS00995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1H54_RS01000	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C1H54_RS01020	COG2972	Histidine kinase
C1H54_RS01025	COG2207	Transcriptional regulator
C1H54_RS01025	COG4753	response regulator
C1H54_RS01035	COG1780	Probably involved in ribonucleotide reductase function
C1H54_RS01065	COG2818	Glycosylase
C1H54_RS01090	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1H54_RS01095	COG0006	proline dipeptidase activity
C1H54_RS01105	COG1393	Belongs to the ArsC family
C1H54_RS01130	COG0285	dihydrofolate synthase activity
C1H54_RS01140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1H54_RS01170	COG0602	queuosine metabolic process
C1H54_RS01205	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C1H54_RS01230	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C1H54_RS01250	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C1H54_RS01265	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C1H54_RS01275	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C1H54_RS01290	COG0201	protein transport
C1H54_RS01300	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C1H54_RS01305	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1H54_RS01315	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C1H54_RS01320	COG0202	RNA polymerase activity
C1H54_RS01330	COG3830	Belongs to the UPF0237 family
C1H54_RS01355	COG1178	ABC-type Fe3 transport system permease component
C1H54_RS01360	COG3842	ATPase activity
C1H54_RS01375	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1H54_RS01380	COG1349	DNA-binding transcription factor activity
C1H54_RS01390	COG1447	Phosphotransferase system cellobiose-specific component IIA
C1H54_RS01395	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C1H54_RS01400	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C1H54_RS01405	COG1882	Formate acetyltransferase
C1H54_RS01450	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C1H54_RS01455	COG4589	Belongs to the CDS family
C1H54_RS01460	COG0750	zinc metalloprotease
C1H54_RS01470	COG2723	6-phospho-beta-galactosidase activity
C1H54_RS01475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C1H54_RS01485	COG1523	belongs to the glycosyl hydrolase 13 family
C1H54_RS01530	COG2309	aminopeptidase activity
C1H54_RS01535	COG2261	transglycosylase associated protein
C1H54_RS01540	COG1187	pseudouridine synthase activity
C1H54_RS01550	COG3579	cysteine-type endopeptidase activity
C1H54_RS01560	COG3715	PTS system
C1H54_RS01570	COG1064	alcohol dehydrogenase
C1H54_RS01575	COG0561	phosphatase activity
C1H54_RS01580	COG2252	PERMEase
C1H54_RS01590	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1H54_RS01605	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C1H54_RS01605	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C1H54_RS01620	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C1H54_RS01645	COG0386	Belongs to the glutathione peroxidase family
C1H54_RS01650	COG5492	domain, Protein
C1H54_RS01690	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C1H54_RS01695	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1H54_RS01700	COG3715	PTS system
C1H54_RS01705	COG3716	PTS system mannose fructose sorbose family IID component
C1H54_RS01720	COG1609	Transcriptional regulator
C1H54_RS01745	COG4839	cell division protein FtsL
C1H54_RS01750	COG0768	penicillin binding
C1H54_RS01780	COG0366	Alpha amylase catalytic
C1H54_RS01785	COG4166	transmembrane transport
C1H54_RS01800	COG4464	protein tyrosine phosphatase activity
C1H54_RS01810	COG0489	protein tyrosine kinase activity
C1H54_RS01820	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C1H54_RS01835	COG1216	Glycosyl transferase, family 2
C1H54_RS01840	COG1216	Glycosyl transferase, family 2
C1H54_RS01840	COG1442	glycosyl transferase family 8
C1H54_RS01865	COG0371	Dehydrogenase
C1H54_RS01870	COG1213	nucleotidyl transferase
C1H54_RS01875	COG0647	UMP catabolic process
C1H54_RS01890	COG4166	transmembrane transport
C1H54_RS01900	COG0366	Alpha amylase catalytic
C1H54_RS01930	COG0116	Belongs to the methyltransferase superfamily
C1H54_RS01940	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C1H54_RS01945	COG0745	RESPONSE REGULATOR receiver
C1H54_RS02005	COG4585	Histidine kinase
C1H54_RS02010	COG2197	response regulator
C1H54_RS02040	COG0582	viral genome integration into host DNA
C1H54_RS02050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1H54_RS02055	COG0681	Belongs to the peptidase S26 family
C1H54_RS02075	COG1193	negative regulation of DNA recombination
C1H54_RS02080	COG1115	amino acid carrier protein
C1H54_RS02105	COG0527	aspartate kinase activity
C1H54_RS02115	COG1024	Enoyl-CoA hydratase
C1H54_RS02120	COG1846	Transcriptional regulator
C1H54_RS02130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1H54_RS02140	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C1H54_RS02145	COG1028	Short-chain dehydrogenase reductase Sdr
C1H54_RS02150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1H54_RS02165	COG0439	Biotin carboxylase
C1H54_RS02170	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C1H54_RS02225	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C1H54_RS02230	COG1442	glycosyl transferase family 8
C1H54_RS02235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C1H54_RS02245	COG1461	Dihydroxyacetone kinase
C1H54_RS02250	COG0028	Belongs to the TPP enzyme family
C1H54_RS02255	COG0440	acetolactate synthase activity
C1H54_RS02275	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1H54_RS02295	COG0765	amino acid transport
C1H54_RS02315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1H54_RS02325	COG1882	Formate acetyltransferase
C1H54_RS02360	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1H54_RS02365	COG0569	domain protein
C1H54_RS02380	COG1122	ATPase activity
C1H54_RS02395	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C1H54_RS02400	COG0671	phosphoesterase, PA-phosphatase related
C1H54_RS02420	COG0504	CTP synthase activity
C1H54_RS02425	COG1283	sodium-dependent phosphate transmembrane transporter activity
C1H54_RS02445	COG0789	Transcriptional regulator
C1H54_RS02450	COG0174	glutamine synthetase
C1H54_RS02495	COG4974	Belongs to the 'phage' integrase family
C1H54_RS02550	COG0484	heat shock protein binding
C1H54_RS02565	COG0537	adenosine 5'-monophosphoramidase activity
C1H54_RS02570	COG1131	(ABC) transporter
C1H54_RS02595	COG3290	protein histidine kinase activity
C1H54_RS02605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1H54_RS02715	COG1266	CAAX protease self-immunity
C1H54_RS02735	COG0195	Participates in both transcription termination and antitermination
C1H54_RS02740	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C1H54_RS02795	COG0519	Catalyzes the synthesis of GMP from XMP
C1H54_RS02805	COG0525	valine-tRNA ligase activity
C1H54_RS02830	COG3711	transcriptional antiterminator
C1H54_RS02835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1H54_RS02835	COG2190	(PTS) system
C1H54_RS02835	COG1263	PTS System
C1H54_RS02850	COG0456	acetyltransferase
C1H54_RS02855	COG0072	phenylalanine-tRNA ligase activity
C1H54_RS02855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1H54_RS02870	COG3620	sequence-specific DNA binding
C1H54_RS02875	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C1H54_RS02895	COG1045	serine acetyltransferase
C1H54_RS02910	COG0215	cysteine-tRNA ligase activity
C1H54_RS02915	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C1H54_RS02930	COG0577	efflux transmembrane transporter activity
C1H54_RS02935	COG1136	(ABC) transporter
C1H54_RS02940	COG0577	efflux transmembrane transporter activity
C1H54_RS02945	COG0745	RESPONSE REGULATOR receiver
C1H54_RS02950	COG5002	protein histidine kinase activity
C1H54_RS02955	COG0191	fructose-bisphosphate aldolase activity
C1H54_RS02960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1H54_RS02965	COG0765	amino acid transport
C1H54_RS02970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1H54_RS02980	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C1H54_RS02980	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C1H54_RS03020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1H54_RS03035	COG1573	uracil-dna glycosylase
C1H54_RS03050	COG1114	Component of the transport system for branched-chain amino acids
C1H54_RS03055	COG1363	Peptidase, m42
C1H54_RS03100	COG4555	ABC transporter
C1H54_RS03115	COG1404	Belongs to the peptidase S8 family
C1H54_RS03130	COG3775	system Galactitol-specific IIC component
C1H54_RS03165	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C1H54_RS03185	COG0785	Cytochrome C biogenesis protein
C1H54_RS03190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1H54_RS03195	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1H54_RS03195	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1H54_RS03200	COG2207	Transcriptional regulator
C1H54_RS03200	COG4753	response regulator
C1H54_RS03205	COG2972	Histidine kinase
C1H54_RS03215	COG3064	Membrane
C1H54_RS03220	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1H54_RS03235	COG1940	carbohydrate kinase activity
C1H54_RS03255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C1H54_RS03260	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C1H54_RS03270	COG0300	oxidoreductase activity
C1H54_RS03290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1H54_RS03300	COG1187	pseudouridine synthase activity
C1H54_RS03305	COG1217	gtp-binding protein TYPA
C1H54_RS03325	COG1136	(ABC) transporter
C1H54_RS03340	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C1H54_RS03345	COG0284	orotidine-5'-phosphate decarboxylase activity
C1H54_RS03350	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C1H54_RS03375	COG1131	(ABC) transporter
C1H54_RS03380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1H54_RS03385	COG1126	abc transporter atp-binding protein
C1H54_RS03390	COG0765	amino acid transport
C1H54_RS03400	COG1304	FMN binding
C1H54_RS03415	COG1304	FMN binding
C1H54_RS03440	COG0352	thiamine-phosphate diphosphorylase activity
C1H54_RS03455	COG4172	Belongs to the ABC transporter superfamily
C1H54_RS03465	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C1H54_RS03480	COG0352	thiamine-phosphate diphosphorylase activity
C1H54_RS03500	COG2217	Heavy metal translocating P-type atpase
C1H54_RS03510	COG0028	Belongs to the TPP enzyme family
C1H54_RS03525	COG2723	6-phospho-beta-galactosidase activity
C1H54_RS03530	COG1482	cell wall glycoprotein biosynthetic process
C1H54_RS03540	COG0789	Transcriptional regulator
C1H54_RS03550	COG2081	HI0933 family
C1H54_RS03555	COG1307	EDD domain protein, DegV family
C1H54_RS03565	COG2131	deaminase
C1H54_RS03570	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C1H54_RS03615	COG0617	tRNA 3'-terminal CCA addition
C1H54_RS03615	COG0517	IMP dehydrogenase activity
C1H54_RS03615	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C1H54_RS03625	COG2884	Cell division ATP-binding protein ftsE
C1H54_RS03630	COG2177	Part of the ABC transporter FtsEX involved in
C1H54_RS03635	COG2190	(PTS) system
C1H54_RS03635	COG1263	PTS System
C1H54_RS03635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1H54_RS03645	COG0513	Belongs to the DEAD box helicase family
C1H54_RS03660	COG0167	dihydroorotate dehydrogenase activity
C1H54_RS03670	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C1H54_RS03675	COG4470	Protein conserved in bacteria
C1H54_RS03690	COG0488	(ABC) transporter
C1H54_RS03745	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C1H54_RS03745	COG1328	CTP reductase activity
C1H54_RS03755	COG4443	Transcriptional Coactivator p15 (PC4)
C1H54_RS03760	COG1268	BioY protein
C1H54_RS03800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1H54_RS03805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1H54_RS03810	COG1136	(ABC) transporter
C1H54_RS03815	COG0577	efflux transmembrane transporter activity
C1H54_RS03820	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1H54_RS03820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1H54_RS03835	COG4989	oxidoreductase activity
C1H54_RS03845	COG1028	Short-chain dehydrogenase reductase Sdr
C1H54_RS03875	COG0745	RESPONSE REGULATOR receiver
C1H54_RS03880	COG5002	protein histidine kinase activity
C1H54_RS03905	COG0772	Belongs to the SEDS family
C1H54_RS03910	COG0693	protein deglycase activity
C1H54_RS03920	COG0187	DNA topoisomerase II activity
C1H54_RS03925	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C1H54_RS03975	COG0542	response to heat
C1H54_RS03980	COG4703	Protein of unknown function (DUF1797)
C1H54_RS03985	COG0765	amino acid transport
C1H54_RS03990	COG1126	abc transporter atp-binding protein
C1H54_RS03995	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C1H54_RS04000	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C1H54_RS04020	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C1H54_RS04070	COG2813	Specifically methylates the guanine in position
C1H54_RS04075	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C1H54_RS04085	COG0295	cytidine deaminase activity
C1H54_RS04090	COG1744	ABC transporter substrate-binding protein PnrA-like
C1H54_RS04100	COG4603	Belongs to the binding-protein-dependent transport system permease family
C1H54_RS04105	COG1079	Belongs to the binding-protein-dependent transport system permease family
C1H54_RS04125	COG0187	DNA topoisomerase II activity
C1H54_RS04130	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1H54_RS04135	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1H54_RS04140	COG4166	transmembrane transport
C1H54_RS04175	COG0539	negative regulation of cytoplasmic translation
C1H54_RS04185	COG1956	GAF domain-containing protein
C1H54_RS04190	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C1H54_RS04205	COG0719	Fe-S assembly protein
C1H54_RS04210	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1H54_RS04220	COG0719	Fe-S assembly protein
C1H54_RS04225	COG1686	Belongs to the peptidase S11 family
C1H54_RS04230	COG0628	permease
C1H54_RS04245	COG1349	DNA-binding transcription factor activity
C1H54_RS04250	COG1105	Belongs to the carbohydrate kinase PfkB family
C1H54_RS04255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1H54_RS04255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1H54_RS04255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1H54_RS04260	COG1674	ftsk spoiiie
C1H54_RS04260	COG0697	spore germination
C1H54_RS04270	COG1104	cysteine desulfurase activity
C1H54_RS04320	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
C1H54_RS04325	COG1438	arginine binding
C1H54_RS04345	COG0469	pyruvate kinase activity
C1H54_RS04350	COG0582	viral genome integration into host DNA
C1H54_RS04400	COG3689	TIGRFAM TIGR03943 family protein
C1H54_RS04405	COG0701	Predicted permease
C1H54_RS04420	COG2183	response to ionizing radiation
C1H54_RS04440	COG1136	(ABC) transporter
C1H54_RS04445	COG0577	efflux transmembrane transporter activity
C1H54_RS04465	COG1982	Orn Lys Arg decarboxylase major
C1H54_RS04475	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C1H54_RS04495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1H54_RS04500	COG0561	phosphatase activity
C1H54_RS04520	COG0583	DNA-binding transcription factor activity
C1H54_RS04525	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C1H54_RS04530	COG0564	pseudouridine synthase activity
C1H54_RS04535	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C1H54_RS04550	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C1H54_RS04560	COG0470	DNA polymerase III
C1H54_RS04600	COG0528	UMP kinase activity
C1H54_RS04610	COG2996	Protein conserved in bacteria
C1H54_RS04620	COG1702	phosphate starvation-inducible protein PhoH
C1H54_RS04640	COG0686	Belongs to the AlaDH PNT family
C1H54_RS04645	COG0686	Belongs to the AlaDH PNT family
C1H54_RS04650	COG0686	Belongs to the AlaDH PNT family
C1H54_RS04660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1H54_RS04670	COG2333	competence protein COMEC
C1H54_RS04670	COG0658	competence protein
C1H54_RS04680	COG1131	(ABC) transporter
C1H54_RS04710	COG0543	2 iron, 2 sulfur cluster binding
C1H54_RS04715	COG0167	dihydroorotate dehydrogenase activity
C1H54_RS04720	COG4193	domain, Protein
C1H54_RS04720	COG5263	repeat protein
C1H54_RS04735	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C1H54_RS04745	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1H54_RS04750	COG0237	dephospho-CoA kinase activity
C1H54_RS04755	COG2814	Major facilitator Superfamily
C1H54_RS04760	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C1H54_RS04770	COG0557	exoribonuclease II activity
C1H54_RS04780	COG3615	Tellurite resistance protein tehB
C1H54_RS04780	COG0500	methyltransferase
C1H54_RS04795	COG4122	O-methyltransferase activity
C1H54_RS04825	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C1H54_RS04845	COG0494	nUDIX hydrolase
C1H54_RS04855	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C1H54_RS04865	COG2176	DNA-directed DNA polymerase activity
C1H54_RS04870	COG0584	glycerophosphoryl diester phosphodiesterase
C1H54_RS04890	COG0785	Cytochrome C biogenesis protein
C1H54_RS04895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1H54_RS04900	COG0531	amino acid
C1H54_RS04905	COG0803	Belongs to the bacterial solute-binding protein 9 family
C1H54_RS04905	COG3443	Belongs to the bacterial solute-binding protein 9 family
C1H54_RS04940	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1H54_RS04950	COG1970	mechanosensitive ion channel activity
C1H54_RS04960	COG4708	membrane
C1H54_RS04970	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1H54_RS04985	COG1942	4-Oxalocrotonate Tautomerase
C1H54_RS04990	COG1435	thymidine kinase activity
C1H54_RS05000	COG2890	protein-(glutamine-N5) methyltransferase activity
C1H54_RS05035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1H54_RS05055	COG0772	Belongs to the SEDS family
C1H54_RS05060	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C1H54_RS05075	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C1H54_RS05080	COG0358	DNA primase activity
C1H54_RS05085	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1H54_RS05090	COG2151	metal-sulfur cluster biosynthetic enzyme
C1H54_RS05095	COG0438	transferase activity, transferring glycosyl groups
C1H54_RS05100	COG0438	transferase activity, transferring glycosyl groups
C1H54_RS05125	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C1H54_RS05135	COG4109	DRTGG domain
C1H54_RS05140	COG0024	Methionine aminopeptidase
C1H54_RS05155	COG0210	DNA helicase
C1H54_RS05165	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C1H54_RS05185	COG1104	cysteine desulfurase activity
C1H54_RS05190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C1H54_RS05200	COG2357	RelA SpoT domain protein
C1H54_RS05210	COG0564	pseudouridine synthase activity
C1H54_RS05215	COG0280	phosphate acetyltransferase
C1H54_RS05275	COG0196	riboflavin kinase activity
C1H54_RS05280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C1H54_RS05285	COG1307	EDD domain protein, DegV family
C1H54_RS05295	COG0488	(ABC) transporter
C1H54_RS05315	COG1523	belongs to the glycosyl hydrolase 13 family
C1H54_RS05320	COG1012	belongs to the aldehyde dehydrogenase family
C1H54_RS05330	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C1H54_RS05340	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C1H54_RS05370	COG0582	viral genome integration into host DNA
C1H54_RS05390	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C1H54_RS05405	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C1H54_RS05405	COG3583	domain protein
C1H54_RS05410	COG3064	Membrane
C1H54_RS05430	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C1H54_RS05450	COG0095	Lipoate-protein ligase
C1H54_RS05455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1H54_RS05460	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1H54_RS05465	COG0022	dehydrogenase e1 component
C1H54_RS05470	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C1H54_RS05475	COG0534	Mate efflux family protein
C1H54_RS05485	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1H54_RS05490	COG1051	belongs to the nudix hydrolase family
C1H54_RS05505	COG1011	Hydrolase
C1H54_RS05510	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
C1H54_RS05525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1H54_RS05530	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C1H54_RS05535	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1H54_RS05540	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1H54_RS05575	COG3711	transcriptional antiterminator
C1H54_RS05580	COG3684	Belongs to the aldolase LacD family
C1H54_RS05630	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C1H54_RS05635	COG0497	DNA recombination
C1H54_RS05640	COG1438	arginine binding
C1H54_RS05645	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C1H54_RS05680	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C1H54_RS05700	COG3764	Sortase (surface protein transpeptidase)
C1H54_RS05705	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1H54_RS05715	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1H54_RS05735	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C1H54_RS05740	COG5002	protein histidine kinase activity
C1H54_RS05745	COG0745	RESPONSE REGULATOR receiver
C1H54_RS05750	COG1194	a g-specific adenine glycosylase
C1H54_RS05765	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C1H54_RS05770	COG4684	Psort location CytoplasmicMembrane, score
C1H54_RS05780	COG1827	regulation of RNA biosynthetic process
C1H54_RS05785	COG2816	NAD+ diphosphatase activity
C1H54_RS05800	COG0556	nucleotide-excision repair
C1H54_RS05810	COG0765	amino acid transport
C1H54_RS05815	COG1126	abc transporter atp-binding protein
C1H54_RS05820	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C1H54_RS05825	COG0552	protein localization to endoplasmic reticulum
C1H54_RS05830	COG0561	phosphatase activity
C1H54_RS05835	COG0561	phosphatase activity
C1H54_RS05840	COG1196	nuclear chromosome segregation
C1H54_RS05865	COG1401	restriction endodeoxyribonuclease activity
C1H54_RS05875	COG0066	3-isopropylmalate dehydratase activity
C1H54_RS05900	COG3142	Participates in the control of copper homeostasis
C1H54_RS05905	COG2832	Protein of unknown function (DUF454)
C1H54_RS05910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1H54_RS05920	COG0758	DNA mediated transformation
C1H54_RS05925	COG4750	Nucleotidyl transferase
C1H54_RS05940	COG1063	alcohol dehydrogenase
C1H54_RS05955	COG3475	LICD family
C1H54_RS05960	COG3475	LICD family
C1H54_RS05970	COG0505	Belongs to the CarA family
C1H54_RS05985	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C1H54_RS06000	COG0488	(ABC) transporter
C1H54_RS06010	COG1704	LemA family
C1H54_RS06025	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C1H54_RS06040	COG1078	dGTPase activity
C1H54_RS06065	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1H54_RS06070	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1H54_RS06075	COG1605	Chorismate mutase
C1H54_RS06075	COG0077	Prephenate dehydratase
C1H54_RS06080	COG0716	FMN binding
C1H54_RS06085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C1H54_RS06105	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C1H54_RS06180	COG1674	ftsk spoiiie
C1H54_RS06190	COG2946	Replication initiation factor
C1H54_RS06240	COG0791	NLP P60 protein
C1H54_RS06240	COG0741	lytic transglycosylase activity
C1H54_RS06355	COG0270	DNA (cytosine-5-)-methyltransferase activity
C1H54_RS06385	COG0402	S-adenosylhomocysteine deaminase activity
C1H54_RS06395	COG1132	(ABC) transporter
C1H54_RS06400	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1H54_RS06400	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1H54_RS06435	COG1215	transferase activity, transferring glycosyl groups
C1H54_RS06460	COG0077	Prephenate dehydratase
C1H54_RS06465	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C1H54_RS06505	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1H54_RS06520	COG4555	ABC transporter
C1H54_RS06555	COG1177	transmembrane transport
C1H54_RS06560	COG3842	ATPase activity
C1H54_RS06575	COG3527	Alpha-acetolactate decarboxylase
C1H54_RS06580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1H54_RS06585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1H54_RS06590	COG0704	Plays a role in the regulation of phosphate uptake
C1H54_RS06595	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1H54_RS06600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1H54_RS06605	COG0581	inorganic phosphate transmembrane transporter activity
C1H54_RS06610	COG0573	inorganic phosphate transmembrane transporter activity
C1H54_RS06615	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C1H54_RS06620	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1H54_RS06620	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C1H54_RS06625	COG0483	inositol monophosphate 1-phosphatase activity
C1H54_RS06635	COG1393	Belongs to the ArsC family
C1H54_RS06645	COG0647	UMP catabolic process
C1H54_RS06655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1H54_RS06675	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C1H54_RS06690	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C1H54_RS06710	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C1H54_RS06730	COG1131	(ABC) transporter
C1H54_RS06745	COG0826	peptidase U32
C1H54_RS06775	COG1132	(ABC) transporter
C1H54_RS06780	COG1132	(ABC) transporter
C1H54_RS06795	COG1129	ABC transporter
C1H54_RS06805	COG4372	Transposase
C1H54_RS06845	COG2188	Transcriptional regulator
C1H54_RS06850	COG0697	spore germination
C1H54_RS06855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C1H54_RS06870	COG0561	phosphatase activity
C1H54_RS06905	COG0492	ferredoxin-NADP+ reductase activity
C1H54_RS06915	COG1126	abc transporter atp-binding protein
C1H54_RS06925	COG1393	Belongs to the ArsC family
C1H54_RS06945	COG1272	protein, Hemolysin III
C1H54_RS06975	COG0431	NADPH-dependent FMN reductase
C1H54_RS06975	COG1053	succinate dehydrogenase
C1H54_RS06975	COG3976	FMN-binding domain protein
C1H54_RS07000	COG0656	L-ascorbic acid biosynthetic process
C1H54_RS07005	COG0726	polysaccharide deacetylase
C1H54_RS07040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C1H54_RS07080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1H54_RS07090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1H54_RS07095	COG1126	abc transporter atp-binding protein
C1H54_RS07110	COG0628	permease
C1H54_RS07115	COG2706	6-phosphogluconolactonase activity
C1H54_RS07180	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C1H54_RS07205	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1H54_RS07210	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C1H54_RS07215	COG0626	cystathionine gamma-synthase activity
C1H54_RS07220	COG1132	(ABC) transporter
C1H54_RS07225	COG1132	(ABC) transporter
C1H54_RS07230	COG4166	transmembrane transport
C1H54_RS07235	COG2244	polysaccharide biosynthetic process
C1H54_RS07240	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1H54_RS07265	COG2827	Endonuclease containing a URI domain
C1H54_RS07270	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C1H54_RS07275	COG1098	S1 RNA binding domain
C1H54_RS07285	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C1H54_RS07290	COG0629	single-stranded DNA binding
C1H54_RS07305	COG0436	Aminotransferase
C1H54_RS07345	COG0242	peptide deformylase activity
C1H54_RS07350	COG0625	glutathione transferase activity
C1H54_RS07360	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C1H54_RS07365	COG0488	(ABC) transporter
C1H54_RS07370	COG0617	tRNA 3'-terminal CCA addition
C1H54_RS07380	COG1307	EDD domain protein, DegV family
C1H54_RS07400	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C1H54_RS07420	COG5263	repeat protein
C1H54_RS07420	COG5632	N-Acetylmuramoyl-L-alanine amidase
C1H54_RS07520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1H54_RS07695	COG0582	viral genome integration into host DNA
C1H54_RS07700	COG1481	regulation of sporulation
C1H54_RS07705	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C1H54_RS07715	COG0251	oxidation-reduction process
C1H54_RS07735	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C1H54_RS07755	COG3935	DnaD domain protein
C1H54_RS07770	COG2226	methyltransferase
C1H54_RS07775	COG3842	ATPase activity
C1H54_RS07785	COG1335	isochorismatase
C1H54_RS07800	COG0513	Belongs to the DEAD box helicase family
C1H54_RS07805	COG2223	nitrite transmembrane transporter activity
C1H54_RS07810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1H54_RS07815	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C1H54_RS07820	COG3442	glutamine amidotransferase
C1H54_RS07825	COG0006	proline dipeptidase activity
C1H54_RS07840	COG4720	Psort location CytoplasmicMembrane, score
C1H54_RS07845	COG0351	phosphomethylpyrimidine kinase
C1H54_RS07870	COG2824	Alkylphosphonate utilization operon protein PhnA
C1H54_RS07890	COG0463	Glycosyl transferase, family 2
C1H54_RS07895	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1H54_RS07900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1H54_RS07905	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C1H54_RS07910	COG2384	SAM-dependent methyltransferase
C1H54_RS07920	COG0204	Acyl-transferase
C1H54_RS07935	COG2910	NAD(P)H-binding
C1H54_RS07970	COG5002	protein histidine kinase activity
C1H54_RS07975	COG0745	RESPONSE REGULATOR receiver
C1H54_RS07990	COG1959	2 iron, 2 sulfur cluster binding
C1H54_RS08025	COG3590	peptidase
C1H54_RS08040	COG0803	Belongs to the bacterial solute-binding protein 9 family
C1H54_RS08045	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C1H54_RS08055	COG1136	(ABC) transporter
C1H54_RS08055	COG0577	efflux transmembrane transporter activity
C1H54_RS08090	COG3599	regulation of cell shape
C1H54_RS08110	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C1H54_RS08130	COG1051	belongs to the nudix hydrolase family
C1H54_RS08135	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C1H54_RS08150	COG0768	penicillin binding
C1H54_RS08165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1H54_RS08185	COG2731	YhcH YjgK YiaL family protein
C1H54_RS08190	COG0395	ABC-type sugar transport system, permease component
C1H54_RS08195	COG1175	transmembrane transport
C1H54_RS08205	COG1263	PTS System
C1H54_RS08205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1H54_RS08205	COG2190	(PTS) system
C1H54_RS08220	COG4409	exo-alpha-(2->6)-sialidase activity
C1H54_RS08230	COG1175	transmembrane transport
C1H54_RS08235	COG1653	transport
C1H54_RS08255	COG3458	cephalosporin-C deacetylase activity
C1H54_RS08270	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C1H54_RS08285	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1H54_RS08290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1H54_RS08305	COG1131	(ABC) transporter
C1H54_RS08335	COG0778	Nitroreductase
C1H54_RS08340	COG1484	DNA-dependent DNA replication
C1H54_RS08355	COG1725	Transcriptional regulator
C1H54_RS08360	COG1131	(ABC) transporter
C1H54_RS08370	COG1668	transmembrane transport
C1H54_RS08375	COG4152	abc transporter atp-binding protein
C1H54_RS08395	COG1940	carbohydrate kinase activity
C1H54_RS08400	COG2190	(PTS) system
C1H54_RS08400	COG1263	PTS System
C1H54_RS08400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1H54_RS08415	COG1621	beta-fructofuranosidase activity
C1H54_RS08420	COG1609	Transcriptional regulator
C1H54_RS08430	COG3425	synthase
C1H54_RS08455	COG2815	serine threonine protein kinase
C1H54_RS08455	COG0515	serine threonine protein kinase
C1H54_RS08460	COG0631	protein serine/threonine phosphatase activity
C1H54_RS08465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1H54_RS08465	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1H54_RS08475	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C1H54_RS08485	COG0194	GDP metabolic process
C1H54_RS08495	COG4115	mRNA cleavage
C1H54_RS08515	COG2226	methyltransferase
C1H54_RS08520	COG0799	negative regulation of ribosome biogenesis
C1H54_RS08530	COG1713	HD superfamily hydrolase involved in NAD metabolism
C1H54_RS08535	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C1H54_RS08540	COG1534	Rna-binding protein
C1H54_RS08545	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C1H54_RS08560	COG0668	transmembrane transport
C1H54_RS08590	COG3118	belongs to the thioredoxin family
C1H54_RS08595	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C1H54_RS08605	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C1H54_RS08620	COG1131	(ABC) transporter
C1H54_RS08625	COG0640	Transcriptional regulator
C1H54_RS08630	COG1164	Oligoendopeptidase f
C1H54_RS08635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C1H54_RS08640	COG2264	protein methyltransferase activity
C1H54_RS08645	COG1051	belongs to the nudix hydrolase family
C1H54_RS08690	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C1H54_RS08700	COG1621	beta-fructofuranosidase activity
C1H54_RS08705	COG1653	transport
C1H54_RS08710	COG0395	ABC-type sugar transport system, permease component
C1H54_RS08715	COG4209	transmembrane transport
C1H54_RS08725	COG3711	transcriptional antiterminator
C1H54_RS08730	COG2261	transglycosylase associated protein
C1H54_RS08750	COG3237	CsbD-like
C1H54_RS08770	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C1H54_RS08780	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C1H54_RS08785	COG1447	Phosphotransferase system cellobiose-specific component IIA
C1H54_RS08790	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C1H54_RS08800	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C1H54_RS08805	COG1846	Transcriptional regulator
C1H54_RS08805	COG1940	carbohydrate kinase activity
C1H54_RS08845	COG0135	phosphoribosylanthranilate isomerase activity
C1H54_RS08860	COG0512	Glutamine amidotransferase of anthranilate synthase
C1H54_RS08865	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1H54_RS08890	COG1285	pathogenesis
C1H54_RS08895	COG1178	ABC-type Fe3 transport system permease component
C1H54_RS08915	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1H54_RS08920	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C1H54_RS08925	COG0704	Plays a role in the regulation of phosphate uptake
C1H54_RS08935	COG5434	Belongs to the glycosyl hydrolase 28 family
C1H54_RS08945	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1H54_RS08950	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1H54_RS08960	COG1132	(ABC) transporter
C1H54_RS08965	COG1132	(ABC) transporter
C1H54_RS08985	COG0708	Exodeoxyribonuclease III
C1H54_RS09005	COG2233	PERMEase
C1H54_RS09030	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C1H54_RS09035	COG1609	Transcriptional regulator
C1H54_RS09040	COG1063	alcohol dehydrogenase
C1H54_RS09045	COG0789	Transcriptional regulator
C1H54_RS09050	COG1230	cation diffusion facilitator family transporter
C1H54_RS09060	COG3201	nicotinamide mononucleotide transporter
C1H54_RS09065	COG1174	glycine betaine transport
C1H54_RS09090	COG1363	Peptidase, m42
C1H54_RS09110	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1H54_RS09115	COG4605	iron ion homeostasis
C1H54_RS09120	COG4604	ABC transporter, ATP-binding protein
C1H54_RS09125	COG4607	ABC-type enterochelin transport system periplasmic component
C1H54_RS09135	COG1187	pseudouridine synthase activity
C1H54_RS09155	COG0517	IMP dehydrogenase activity
C1H54_RS09165	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C1H54_RS09180	COG0366	Alpha amylase catalytic
C1H54_RS09190	COG1263	PTS System
C1H54_RS09190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1H54_RS09195	COG2188	Transcriptional regulator
C1H54_RS09200	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C1H54_RS09205	COG4120	Belongs to the binding-protein-dependent transport system permease family
C1H54_RS09215	COG4608	Belongs to the ABC transporter superfamily
C1H54_RS09220	COG0444	Belongs to the ABC transporter superfamily
C1H54_RS09225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1H54_RS09230	COG0601	transmembrane transport
C1H54_RS09235	COG4166	transmembrane transport
C1H54_RS09255	COG0366	Alpha amylase catalytic
C1H54_RS09260	COG0395	ABC-type sugar transport system, permease component
C1H54_RS09270	COG1653	transport
C1H54_RS09275	COG3345	alpha-galactosidase
C1H54_RS09280	COG2207	Transcriptional regulator
C1H54_RS09285	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C1H54_RS09285	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C1H54_RS09400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1H54_RS09445	COG4221	oxidoreductase activity
C1H54_RS09450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1H54_RS09455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1H54_RS09555	COG3842	ATPase activity
C1H54_RS09560	COG1178	ABC-type Fe3 transport system permease component
C1H54_RS09565	COG1285	pathogenesis
C1H54_RS09585	COG5632	N-Acetylmuramoyl-L-alanine amidase
C1H54_RS09585	COG5263	repeat protein
C1H54_RS09605	COG1316	TRANSCRIPTIONal
C1H54_RS09615	COG0802	atpase or kinase
C1H54_RS09645	COG1253	flavin adenine dinucleotide binding
C1H54_RS09660	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C1H54_RS09670	COG3480	Lon protease (S16) C-terminal proteolytic domain
C1H54_RS09680	COG0742	ribosomal rna small subunit methyltransferase
C1H54_RS09700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1H54_RS09705	COG1254	Belongs to the acylphosphatase family
C1H54_RS09720	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1H54_RS09730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C1H54_RS09750	COG1564	THIamine pyrophosphokinase
C1H54_RS09760	COG1162	GTPase activity
C1H54_RS09795	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C1H54_RS09800	COG0084	hydrolase, TatD family'
C1H54_RS09820	COG0436	Aminotransferase
C1H54_RS09830	COG0589	response to stress
C1H54_RS09835	COG0561	phosphatase activity
C1H54_RS09840	COG0252	asparaginase activity
C1H54_RS09850	COG1609	Transcriptional regulator
C1H54_RS09855	COG2197	response regulator
C1H54_RS09860	COG4585	Histidine kinase
C1H54_RS09865	COG0842	Transport permease protein
C1H54_RS09870	COG1131	(ABC) transporter
C1H54_RS09970	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C1H54_RS09975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1H54_RS09980	COG0564	pseudouridine synthase activity
C1H54_RS09990	COG0577	efflux transmembrane transporter activity
C1H54_RS10000	COG0157	Belongs to the NadC ModD family
C1H54_RS10015	COG1129	ABC transporter
C1H54_RS10020	COG2188	Transcriptional regulator
C1H54_RS10025	COG2723	6-phospho-beta-galactosidase activity
C1H54_RS10030	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C1H54_RS10040	COG1447	Phosphotransferase system cellobiose-specific component IIA
C1H54_RS10045	COG1454	alcohol dehydrogenase
C1H54_RS10045	COG1012	belongs to the aldehyde dehydrogenase family
C1H54_RS10055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1H54_RS10065	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C1H54_RS10085	COG3623	hexulose-6-phosphate isomerase
C1H54_RS10095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1H54_RS10105	COG3037	sugar-specific permease SgaT UlaA
C1H54_RS10115	COG1847	R3H domain protein
C1H54_RS10120	COG0706	membrane insertase activity
C1H54_RS10165	COG4537	Required for transformation and DNA binding
C1H54_RS10170	COG1459	type II secretion system
C1H54_RS10175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1H54_RS10185	COG1063	alcohol dehydrogenase
C1H54_RS10210	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C1H54_RS10215	COG3759	membrane
C1H54_RS10230	COG0131	Imidazoleglycerol-phosphate dehydratase
C1H54_RS10230	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1H54_RS10235	COG0534	Mate efflux family protein
C1H54_RS10350	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C1H54_RS10355	COG1132	(ABC) transporter
C1H54_RS10365	COG1132	(ABC) transporter
C1H54_RS10375	COG1438	arginine binding
C1H54_RS10405	COG5002	protein histidine kinase activity
C1H54_RS10410	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C1H54_RS10415	COG0573	inorganic phosphate transmembrane transporter activity
C1H54_RS10425	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1H54_RS10430	COG0704	Plays a role in the regulation of phosphate uptake
C1H54_RS10450	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C1H54_RS10460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C1H54_RS10475	COG0697	spore germination
C1H54_RS10490	COG2217	Heavy metal translocating P-type atpase
C1H54_RS10500	COG2226	methyltransferase
C1H54_RS10520	COG0058	SHG alpha-glucan phosphorylase activity
C1H54_RS10525	COG1640	4-alpha-glucanotransferase
C1H54_RS10530	COG2182	Extracellular solute-binding protein
C1H54_RS10535	COG1175	transmembrane transport
C1H54_RS10540	COG3833	ABC-type maltose transport systems, permease component
C1H54_RS10545	COG5521	maltodextrose utilization protein MalA
C1H54_RS10550	COG1609	Transcriptional regulator
C1H54_RS10560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C1H54_RS10565	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C1H54_RS10595	COG1476	TRANSCRIPTIONal
C1H54_RS10630	COG2151	metal-sulfur cluster biosynthetic enzyme
C1H54_RS10645	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1H54_RS10650	COG3959	Transketolase, thiamine diphosphate binding domain
C1H54_RS10685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C1H54_RS10715	COG0383	alpha-mannosidase activity
C1H54_RS10725	COG3537	Alpha-1,2-mannosidase
C1H54_RS10750	COG0549	Belongs to the carbamate kinase family
C1H54_RS10755	COG1288	antiporter activity
C1H54_RS10760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1H54_RS10770	COG3583	domain protein
C1H54_RS10770	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1H54_RS10770	COG3064	Membrane
C1H54_RS10785	COG1454	alcohol dehydrogenase
C1H54_RS10790	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
C1H54_RS10805	COG3716	PTS system mannose fructose sorbose family IID component
C1H54_RS10815	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1H54_RS10835	COG1070	Carbohydrate kinase
C1H54_RS10845	COG3443	Belongs to the bacterial solute-binding protein 9 family
C1H54_RS10845	COG0803	Belongs to the bacterial solute-binding protein 9 family
C1H54_RS10850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1H54_RS10855	COG1121	(ABC) transporter
C1H54_RS10860	COG1846	Transcriptional regulator
C1H54_RS10875	COG1696	Membrane protein involved in D-alanine export
C1H54_RS10890	COG2211	Major facilitator Superfamily
C1H54_RS10900	COG3344	reverse transcriptase
C1H54_RS10930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C1H54_RS10935	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C1H54_RS10955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1H54_RS10965	COG1755	Isoprenylcysteine carboxyl methyltransferase
C1H54_RS10970	COG5002	protein histidine kinase activity
C1H54_RS10975	COG0745	RESPONSE REGULATOR receiver
C1H54_RS10985	COG0542	response to heat
C1H54_RS10990	COG4463	regulation of RNA biosynthetic process
C1H54_RS10995	COG1116	anion transmembrane transporter activity
C1H54_RS11000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1H54_RS11005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1H54_RS11025	COG0305	Participates in initiation and elongation during chromosome replication
C1H54_RS11045	COG1040	competence protein
C1H54_RS11050	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C1H54_RS11055	COG1739	Uncharacterized protein family UPF0029
C1H54_RS11095	COG3942	CHAP domain
C1H54_RS11105	COG1792	Involved in formation and maintenance of cell shape
C1H54_RS11110	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C1H54_RS11115	COG1122	ATPase activity
C1H54_RS11120	COG1122	ATPase activity
C1H54_RS11125	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C1H54_RS11135	COG0612	Peptidase, M16
C1H54_RS11140	COG0612	Peptidase, M16
C1H54_RS11145	COG2501	S4 domain
C1H54_RS11155	COG0516	GMP reductase activity
C1H54_RS11155	COG0517	IMP dehydrogenase activity
C1H54_RS11160	COG0180	Tryptophanyl-tRNA synthetase
C1H54_RS11165	COG0488	(ABC) transporter
C1H54_RS11175	COG1511	domain protein
C1H54_RS11175	COG1511	domain protein
C1H54_RS11220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1H54_RS11225	COG1475	DNA binding