locus-tag	class	description
HMPREF0837_RS00050	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HMPREF0837_RS00055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HMPREF0837_RS00060	COG0564	pseudouridine synthase activity
HMPREF0837_RS00070	COG0577	efflux transmembrane transporter activity
HMPREF0837_RS00090	COG0157	Belongs to the NadC ModD family
HMPREF0837_RS00100	COG4133	protoheme IX ABC transporter activity
HMPREF0837_RS00105	COG2188	Transcriptional regulator
HMPREF0837_RS00110	COG2723	6-phospho-beta-galactosidase activity
HMPREF0837_RS00115	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HMPREF0837_RS00125	COG1447	Phosphotransferase system cellobiose-specific component IIA
HMPREF0837_RS00130	COG1454	alcohol dehydrogenase
HMPREF0837_RS00130	COG1012	belongs to the aldehyde dehydrogenase family
HMPREF0837_RS00140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HMPREF0837_RS00150	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HMPREF0837_RS00170	COG3623	hexulose-6-phosphate isomerase
HMPREF0837_RS00180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF0837_RS00190	COG3037	sugar-specific permease SgaT UlaA
HMPREF0837_RS00200	COG1847	R3H domain protein
HMPREF0837_RS00205	COG0706	membrane insertase activity
HMPREF0837_RS00250	COG4537	Required for transformation and DNA binding
HMPREF0837_RS00255	COG1459	type II secretion system
HMPREF0837_RS00260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HMPREF0837_RS00270	COG1063	alcohol dehydrogenase
HMPREF0837_RS00295	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HMPREF0837_RS00300	COG3759	membrane
HMPREF0837_RS00315	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HMPREF0837_RS00315	COG0131	Imidazoleglycerol-phosphate dehydratase
HMPREF0837_RS00320	COG0534	Mate efflux family protein
HMPREF0837_RS00435	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HMPREF0837_RS00440	COG1132	(ABC) transporter
HMPREF0837_RS00450	COG1132	(ABC) transporter
HMPREF0837_RS00460	COG1438	arginine binding
HMPREF0837_RS00480	COG0745	RESPONSE REGULATOR receiver
HMPREF0837_RS00485	COG5002	protein histidine kinase activity
HMPREF0837_RS00490	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HMPREF0837_RS00495	COG0573	inorganic phosphate transmembrane transporter activity
HMPREF0837_RS00505	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HMPREF0837_RS00510	COG0704	Plays a role in the regulation of phosphate uptake
HMPREF0837_RS00530	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HMPREF0837_RS00540	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HMPREF0837_RS00555	COG0697	spore germination
HMPREF0837_RS00560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HMPREF0837_RS00560	COG4499	WXG100 protein secretion system (Wss), protein YukC
HMPREF0837_RS00570	COG2217	Heavy metal translocating P-type atpase
HMPREF0837_RS00580	COG2226	methyltransferase
HMPREF0837_RS00600	COG0058	SHG alpha-glucan phosphorylase activity
HMPREF0837_RS00605	COG1640	4-alpha-glucanotransferase
HMPREF0837_RS00610	COG2182	Extracellular solute-binding protein
HMPREF0837_RS00615	COG1175	transmembrane transport
HMPREF0837_RS00620	COG3833	ABC-type maltose transport systems, permease component
HMPREF0837_RS00625	COG5521	maltodextrose utilization protein MalA
HMPREF0837_RS00630	COG1609	Transcriptional regulator
HMPREF0837_RS00635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HMPREF0837_RS00670	COG1476	TRANSCRIPTIONal
HMPREF0837_RS00695	COG1396	sequence-specific DNA binding
HMPREF0837_RS00700	COG2151	metal-sulfur cluster biosynthetic enzyme
HMPREF0837_RS00710	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HMPREF0837_RS00715	COG3959	Transketolase, thiamine diphosphate binding domain
HMPREF0837_RS00730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF0837_RS00750	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HMPREF0837_RS00790	COG0383	alpha-mannosidase activity
HMPREF0837_RS00800	COG3537	Alpha-1,2-mannosidase
HMPREF0837_RS00820	COG0549	Belongs to the carbamate kinase family
HMPREF0837_RS00825	COG1288	antiporter activity
HMPREF0837_RS00830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HMPREF0837_RS00845	COG3064	Membrane
HMPREF0837_RS00845	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HMPREF0837_RS00845	COG3583	domain protein
HMPREF0837_RS00860	COG1454	alcohol dehydrogenase
HMPREF0837_RS00880	COG3716	PTS system mannose fructose sorbose family IID component
HMPREF0837_RS00890	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF0837_RS00910	COG1070	Carbohydrate kinase
HMPREF0837_RS00920	COG0803	Belongs to the bacterial solute-binding protein 9 family
HMPREF0837_RS00920	COG3443	Belongs to the bacterial solute-binding protein 9 family
HMPREF0837_RS00925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HMPREF0837_RS00930	COG1121	(ABC) transporter
HMPREF0837_RS00935	COG1846	Transcriptional regulator
HMPREF0837_RS00940	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HMPREF0837_RS00950	COG1696	Membrane protein involved in D-alanine export
HMPREF0837_RS00965	COG2211	Major facilitator Superfamily
HMPREF0837_RS00970	COG3344	reverse transcriptase
HMPREF0837_RS00990	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HMPREF0837_RS00995	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HMPREF0837_RS01045	COG1755	Isoprenylcysteine carboxyl methyltransferase
HMPREF0837_RS01050	COG5002	protein histidine kinase activity
HMPREF0837_RS01055	COG0745	RESPONSE REGULATOR receiver
HMPREF0837_RS01065	COG0542	response to heat
HMPREF0837_RS01070	COG4463	regulation of RNA biosynthetic process
HMPREF0837_RS01075	COG1116	anion transmembrane transporter activity
HMPREF0837_RS01080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HMPREF0837_RS01085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HMPREF0837_RS01105	COG0305	Participates in initiation and elongation during chromosome replication
HMPREF0837_RS01125	COG1040	competence protein
HMPREF0837_RS01135	COG1739	Uncharacterized protein family UPF0029
HMPREF0837_RS01150	COG3335	DDE superfamily endonuclease
HMPREF0837_RS01170	COG3942	CHAP domain
HMPREF0837_RS01180	COG1792	Involved in formation and maintenance of cell shape
HMPREF0837_RS01185	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HMPREF0837_RS01190	COG1122	ATPase activity
HMPREF0837_RS01195	COG1122	ATPase activity
HMPREF0837_RS01200	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HMPREF0837_RS01210	COG0612	Peptidase, M16
HMPREF0837_RS01215	COG0612	Peptidase, M16
HMPREF0837_RS01220	COG2501	S4 domain
HMPREF0837_RS01230	COG0516	GMP reductase activity
HMPREF0837_RS01230	COG0517	IMP dehydrogenase activity
HMPREF0837_RS01235	COG0180	Tryptophanyl-tRNA synthetase
HMPREF0837_RS01240	COG0488	(ABC) transporter
HMPREF0837_RS01250	COG1511	domain protein
HMPREF0837_RS01255	COG1511	domain protein
HMPREF0837_RS01300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HMPREF0837_RS01305	COG1475	DNA binding
HMPREF0837_RS01315	COG0592	DNA-directed DNA polymerase activity
HMPREF0837_RS01460	COG3645	SOS response
HMPREF0837_RS01465	COG4974	Belongs to the 'phage' integrase family
HMPREF0837_RS01470	COG0012	GTP binding
HMPREF0837_RS01480	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HMPREF0837_RS01485	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HMPREF0837_RS01510	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HMPREF0837_RS01515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HMPREF0837_RS01580	COG0756	dUTP diphosphatase activity
HMPREF0837_RS01590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HMPREF0837_RS01605	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HMPREF0837_RS01625	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HMPREF0837_RS01625	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HMPREF0837_RS01630	COG1832	CoA-binding protein
HMPREF0837_RS01640	COG2855	membrane
HMPREF0837_RS01645	COG0436	Aminotransferase
HMPREF0837_RS01650	COG1381	Involved in DNA repair and RecF pathway recombination
HMPREF0837_RS01660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HMPREF0837_RS01685	COG2274	protein secretion by the type I secretion system
HMPREF0837_RS01690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HMPREF0837_RS01700	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HMPREF0837_RS01705	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HMPREF0837_RS01715	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HMPREF0837_RS01730	COG0151	Belongs to the GarS family
HMPREF0837_RS01735	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HMPREF0837_RS01750	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HMPREF0837_RS01755	COG3064	Membrane
HMPREF0837_RS01755	COG3583	domain protein
HMPREF0837_RS01755	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HMPREF0837_RS01770	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF0837_RS01775	COG3715	PTS system
HMPREF0837_RS01780	COG3716	PTS system mannose fructose sorbose family IID component
HMPREF0837_RS01790	COG2222	sugar isomerase
HMPREF0837_RS01800	COG2514	catechol 2,3-dioxygenase activity
HMPREF0837_RS01805	COG1937	Protein conserved in bacteria
HMPREF0837_RS01830	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HMPREF0837_RS01835	COG0569	domain protein
HMPREF0837_RS01845	COG1215	transferase activity, transferring glycosyl groups
HMPREF0837_RS01865	COG5002	protein histidine kinase activity
HMPREF0837_RS01890	COG4209	transmembrane transport
HMPREF0837_RS01895	COG0395	ABC-type sugar transport system, permease component
HMPREF0837_RS01905	COG1653	transport
HMPREF0837_RS01930	COG1136	(ABC) transporter
HMPREF0837_RS01930	COG0577	efflux transmembrane transporter activity
HMPREF0837_RS01950	COG1695	Transcriptional regulator
HMPREF0837_RS01975	COG0546	phosphoglycolate phosphatase activity
HMPREF0837_RS01980	COG1760	l-serine dehydratase
HMPREF0837_RS01985	COG1760	l-serine dehydratase
HMPREF0837_RS01990	COG1705	Flagellar rod assembly protein muramidase FlgJ
HMPREF0837_RS01990	COG1388	LysM domain
HMPREF0837_RS02015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF0837_RS02020	COG0137	argininosuccinate synthase activity
HMPREF0837_RS02120	COG0494	nUDIX hydrolase
HMPREF0837_RS02125	COG0445	tRNA wobble uridine modification
HMPREF0837_RS02160	COG1214	PFAM Peptidase M22, glycoprotease
HMPREF0837_RS02200	COG0438	transferase activity, transferring glycosyl groups
HMPREF0837_RS02235	COG1396	sequence-specific DNA binding
HMPREF0837_RS02265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF0837_RS02270	COG1464	Belongs to the NlpA lipoprotein family
HMPREF0837_RS02275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HMPREF0837_RS02280	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HMPREF0837_RS02300	COG2972	Histidine kinase
HMPREF0837_RS02305	COG2207	Transcriptional regulator
HMPREF0837_RS02305	COG4753	response regulator
HMPREF0837_RS02315	COG1780	Probably involved in ribonucleotide reductase function
HMPREF0837_RS02345	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HMPREF0837_RS02345	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HMPREF0837_RS02365	COG2818	Glycosylase
HMPREF0837_RS02465	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HMPREF0837_RS02470	COG0006	proline dipeptidase activity
HMPREF0837_RS02475	COG1393	Belongs to the ArsC family
HMPREF0837_RS02500	COG0285	dihydrofolate synthase activity
HMPREF0837_RS02510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HMPREF0837_RS02575	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HMPREF0837_RS02600	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HMPREF0837_RS02640	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HMPREF0837_RS02655	COG0201	protein transport
HMPREF0837_RS02665	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HMPREF0837_RS02670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HMPREF0837_RS02680	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HMPREF0837_RS02685	COG0202	RNA polymerase activity
HMPREF0837_RS02695	COG3830	Belongs to the UPF0237 family
HMPREF0837_RS02715	COG1178	ABC-type Fe3 transport system permease component
HMPREF0837_RS02725	COG1840	ABC-type Fe3 transport system, periplasmic component
HMPREF0837_RS02740	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HMPREF0837_RS02745	COG1349	DNA-binding transcription factor activity
HMPREF0837_RS02755	COG1447	Phosphotransferase system cellobiose-specific component IIA
HMPREF0837_RS02760	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HMPREF0837_RS02765	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HMPREF0837_RS02770	COG1882	Formate acetyltransferase
HMPREF0837_RS02820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HMPREF0837_RS02825	COG4589	Belongs to the CDS family
HMPREF0837_RS02830	COG0750	zinc metalloprotease
HMPREF0837_RS02840	COG2723	6-phospho-beta-galactosidase activity
HMPREF0837_RS02845	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HMPREF0837_RS02860	COG1523	belongs to the glycosyl hydrolase 13 family
HMPREF0837_RS02880	COG2176	DNA-directed DNA polymerase activity
HMPREF0837_RS02900	COG2309	aminopeptidase activity
HMPREF0837_RS02905	COG2261	transglycosylase associated protein
HMPREF0837_RS02910	COG1187	pseudouridine synthase activity
HMPREF0837_RS02920	COG3579	cysteine-type endopeptidase activity
HMPREF0837_RS02925	COG3716	PTS system mannose fructose sorbose family IID component
HMPREF0837_RS02930	COG3715	PTS system
HMPREF0837_RS02940	COG1064	alcohol dehydrogenase
HMPREF0837_RS02945	COG0561	phosphatase activity
HMPREF0837_RS02950	COG2252	PERMEase
HMPREF0837_RS02960	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HMPREF0837_RS02965	COG0285	dihydrofolate synthase activity
HMPREF0837_RS02975	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HMPREF0837_RS02975	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HMPREF0837_RS02985	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HMPREF0837_RS03010	COG0386	Belongs to the glutathione peroxidase family
HMPREF0837_RS03040	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF0837_RS03050	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HMPREF0837_RS03055	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF0837_RS03060	COG3715	PTS system
HMPREF0837_RS03065	COG3716	PTS system mannose fructose sorbose family IID component
HMPREF0837_RS03080	COG1609	Transcriptional regulator
HMPREF0837_RS03110	COG4839	cell division protein FtsL
HMPREF0837_RS03115	COG0768	penicillin binding
HMPREF0837_RS03140	COG0366	Alpha amylase catalytic
HMPREF0837_RS03145	COG4166	transmembrane transport
HMPREF0837_RS03160	COG4464	protein tyrosine phosphatase activity
HMPREF0837_RS03165	COG3944	biosynthesis protein
HMPREF0837_RS03170	COG0489	protein tyrosine kinase activity
HMPREF0837_RS03185	COG3475	LICD family
HMPREF0837_RS03205	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HMPREF0837_RS03210	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HMPREF0837_RS03220	COG1088	dTDP-glucose 4,6-dehydratase activity
HMPREF0837_RS03225	COG1091	dTDP-4-dehydrorhamnose reductase activity
HMPREF0837_RS03235	COG4166	transmembrane transport
HMPREF0837_RS03240	COG0366	Alpha amylase catalytic
HMPREF0837_RS03245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HMPREF0837_RS03270	COG0116	Belongs to the methyltransferase superfamily
HMPREF0837_RS03280	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HMPREF0837_RS03285	COG0745	RESPONSE REGULATOR receiver
HMPREF0837_RS03340	COG4585	Histidine kinase
HMPREF0837_RS03345	COG2197	response regulator
HMPREF0837_RS03375	COG0582	viral genome integration into host DNA
HMPREF0837_RS03385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HMPREF0837_RS03390	COG0681	Belongs to the peptidase S26 family
HMPREF0837_RS03415	COG1115	amino acid carrier protein
HMPREF0837_RS03440	COG0527	aspartate kinase activity
HMPREF0837_RS03445	COG1024	Enoyl-CoA hydratase
HMPREF0837_RS03450	COG1846	Transcriptional regulator
HMPREF0837_RS03460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HMPREF0837_RS03470	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HMPREF0837_RS03475	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF0837_RS03480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HMPREF0837_RS03495	COG0439	Biotin carboxylase
HMPREF0837_RS03500	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HMPREF0837_RS03535	COG1063	alcohol dehydrogenase
HMPREF0837_RS03565	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HMPREF0837_RS03575	COG1461	Dihydroxyacetone kinase
HMPREF0837_RS03580	COG0028	Belongs to the TPP enzyme family
HMPREF0837_RS03585	COG0440	acetolactate synthase activity
HMPREF0837_RS03605	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HMPREF0837_RS03620	COG0765	amino acid transport
HMPREF0837_RS03650	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMPREF0837_RS03655	COG1882	Formate acetyltransferase
HMPREF0837_RS03725	COG1940	carbohydrate kinase activity
HMPREF0837_RS03725	COG1846	Transcriptional regulator
HMPREF0837_RS03730	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HMPREF0837_RS03740	COG1447	Phosphotransferase system cellobiose-specific component IIA
HMPREF0837_RS03745	COG2723	6-phospho-beta-galactosidase activity
HMPREF0837_RS03750	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HMPREF0837_RS03750	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HMPREF0837_RS03755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HMPREF0837_RS03760	COG0569	domain protein
HMPREF0837_RS03780	COG1122	ATPase activity
HMPREF0837_RS03795	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HMPREF0837_RS03800	COG0671	phosphoesterase, PA-phosphatase related
HMPREF0837_RS03810	COG1247	-acetyltransferase
HMPREF0837_RS03825	COG0504	CTP synthase activity
HMPREF0837_RS03830	COG1283	sodium-dependent phosphate transmembrane transporter activity
HMPREF0837_RS03850	COG0789	Transcriptional regulator
HMPREF0837_RS03855	COG0174	glutamine synthetase
HMPREF0837_RS03870	COG4974	Belongs to the 'phage' integrase family
HMPREF0837_RS03880	COG0732	type I restriction modification DNA specificity domain
HMPREF0837_RS03925	COG0484	heat shock protein binding
HMPREF0837_RS03940	COG0537	adenosine 5'-monophosphoramidase activity
HMPREF0837_RS03945	COG1131	(ABC) transporter
HMPREF0837_RS03950	COG4473	ABC transporter
HMPREF0837_RS03970	COG3290	protein histidine kinase activity
HMPREF0837_RS03985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HMPREF0837_RS04055	COG1266	CAAX protease self-immunity
HMPREF0837_RS04075	COG0195	Participates in both transcription termination and antitermination
HMPREF0837_RS04080	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HMPREF0837_RS04145	COG0519	Catalyzes the synthesis of GMP from XMP
HMPREF0837_RS04155	COG0525	valine-tRNA ligase activity
HMPREF0837_RS04175	COG2801	Transposase and inactivated derivatives
HMPREF0837_RS04190	COG3711	transcriptional antiterminator
HMPREF0837_RS04195	COG2190	(PTS) system
HMPREF0837_RS04195	COG1263	PTS System
HMPREF0837_RS04195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF0837_RS04210	COG0456	acetyltransferase
HMPREF0837_RS04215	COG0072	phenylalanine-tRNA ligase activity
HMPREF0837_RS04215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPREF0837_RS04235	COG3620	sequence-specific DNA binding
HMPREF0837_RS04245	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HMPREF0837_RS04255	COG1045	serine acetyltransferase
HMPREF0837_RS04265	COG0215	cysteine-tRNA ligase activity
HMPREF0837_RS04270	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HMPREF0837_RS04290	COG0577	efflux transmembrane transporter activity
HMPREF0837_RS04295	COG1136	(ABC) transporter
HMPREF0837_RS04300	COG0577	efflux transmembrane transporter activity
HMPREF0837_RS04305	COG0745	RESPONSE REGULATOR receiver
HMPREF0837_RS04310	COG5002	protein histidine kinase activity
HMPREF0837_RS04315	COG0191	fructose-bisphosphate aldolase activity
HMPREF0837_RS04320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HMPREF0837_RS04330	COG0765	amino acid transport
HMPREF0837_RS04335	COG0765	amino acid transport
HMPREF0837_RS04340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF0837_RS04350	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HMPREF0837_RS04350	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HMPREF0837_RS04390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF0837_RS04405	COG1573	uracil-dna glycosylase
HMPREF0837_RS04415	COG1114	Component of the transport system for branched-chain amino acids
HMPREF0837_RS04420	COG1363	Peptidase, m42
HMPREF0837_RS04460	COG4555	ABC transporter
HMPREF0837_RS04485	COG1404	Belongs to the peptidase S8 family
HMPREF0837_RS04500	COG3775	system Galactitol-specific IIC component
HMPREF0837_RS04510	COG3250	beta-galactosidase activity
HMPREF0837_RS04545	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HMPREF0837_RS04565	COG0785	Cytochrome C biogenesis protein
HMPREF0837_RS04570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HMPREF0837_RS04575	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMPREF0837_RS04575	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMPREF0837_RS04580	COG4753	response regulator
HMPREF0837_RS04580	COG2207	Transcriptional regulator
HMPREF0837_RS04585	COG2972	Histidine kinase
HMPREF0837_RS04595	COG3064	Membrane
HMPREF0837_RS04600	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HMPREF0837_RS04615	COG1940	carbohydrate kinase activity
HMPREF0837_RS04635	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HMPREF0837_RS04640	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HMPREF0837_RS04650	COG0300	oxidoreductase activity
HMPREF0837_RS04665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HMPREF0837_RS04675	COG1187	pseudouridine synthase activity
HMPREF0837_RS04680	COG1217	gtp-binding protein TYPA
HMPREF0837_RS04700	COG1136	(ABC) transporter
HMPREF0837_RS04715	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HMPREF0837_RS04725	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HMPREF0837_RS04750	COG1131	(ABC) transporter
HMPREF0837_RS04755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF0837_RS04765	COG1126	abc transporter atp-binding protein
HMPREF0837_RS04770	COG1129	ABC transporter
HMPREF0837_RS04785	COG0765	amino acid transport
HMPREF0837_RS04795	COG1304	FMN binding
HMPREF0837_RS04800	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HMPREF0837_RS04810	COG1304	FMN binding
HMPREF0837_RS04825	COG0352	thiamine-phosphate diphosphorylase activity
HMPREF0837_RS04835	COG4172	Belongs to the ABC transporter superfamily
HMPREF0837_RS04845	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HMPREF0837_RS04860	COG0352	thiamine-phosphate diphosphorylase activity
HMPREF0837_RS04880	COG2217	Heavy metal translocating P-type atpase
HMPREF0837_RS04885	COG0028	Belongs to the TPP enzyme family
HMPREF0837_RS04895	COG3335	DDE superfamily endonuclease
HMPREF0837_RS04905	COG2723	6-phospho-beta-galactosidase activity
HMPREF0837_RS04910	COG1482	cell wall glycoprotein biosynthetic process
HMPREF0837_RS04915	COG0733	neurotransmitter:sodium symporter activity
HMPREF0837_RS04920	COG0789	Transcriptional regulator
HMPREF0837_RS04930	COG2081	HI0933 family
HMPREF0837_RS04935	COG1307	EDD domain protein, DegV family
HMPREF0837_RS04945	COG2131	deaminase
HMPREF0837_RS04950	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HMPREF0837_RS04990	COG0617	tRNA 3'-terminal CCA addition
HMPREF0837_RS04990	COG0517	IMP dehydrogenase activity
HMPREF0837_RS04990	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HMPREF0837_RS04995	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HMPREF0837_RS05000	COG2884	Cell division ATP-binding protein ftsE
HMPREF0837_RS05005	COG2177	Part of the ABC transporter FtsEX involved in
HMPREF0837_RS05010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF0837_RS05010	COG1263	PTS System
HMPREF0837_RS05010	COG2190	(PTS) system
HMPREF0837_RS05020	COG0513	Belongs to the DEAD box helicase family
HMPREF0837_RS05030	COG0167	dihydroorotate dehydrogenase activity
HMPREF0837_RS05040	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HMPREF0837_RS05045	COG4470	Protein conserved in bacteria
HMPREF0837_RS05060	COG0488	(ABC) transporter
HMPREF0837_RS05085	COG1837	Belongs to the UPF0109 family
HMPREF0837_RS05105	COG3335	DDE superfamily endonuclease
HMPREF0837_RS05115	COG0513	Belongs to the DEAD box helicase family
HMPREF0837_RS05130	COG0726	polysaccharide deacetylase
HMPREF0837_RS05135	COG0656	L-ascorbic acid biosynthetic process
HMPREF0837_RS05160	COG3976	FMN-binding domain protein
HMPREF0837_RS05160	COG1053	succinate dehydrogenase
HMPREF0837_RS05160	COG0431	NADPH-dependent FMN reductase
HMPREF0837_RS05190	COG1272	protein, Hemolysin III
HMPREF0837_RS05205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HMPREF0837_RS05210	COG1393	Belongs to the ArsC family
HMPREF0837_RS05220	COG1126	abc transporter atp-binding protein
HMPREF0837_RS05230	COG0492	ferredoxin-NADP+ reductase activity
HMPREF0837_RS05260	COG0561	phosphatase activity
HMPREF0837_RS05275	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HMPREF0837_RS05280	COG0697	spore germination
HMPREF0837_RS05285	COG2188	Transcriptional regulator
HMPREF0837_RS05315	COG1132	(ABC) transporter
HMPREF0837_RS05320	COG1132	(ABC) transporter
HMPREF0837_RS05335	COG1129	ABC transporter
HMPREF0837_RS05365	COG0826	peptidase U32
HMPREF0837_RS05370	COG0826	peptidase U32
HMPREF0837_RS05375	COG1131	(ABC) transporter
HMPREF0837_RS05395	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HMPREF0837_RS05405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HMPREF0837_RS05425	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HMPREF0837_RS05460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HMPREF0837_RS05470	COG0647	UMP catabolic process
HMPREF0837_RS05480	COG1393	Belongs to the ArsC family
HMPREF0837_RS05490	COG0483	inositol monophosphate 1-phosphatase activity
HMPREF0837_RS05495	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HMPREF0837_RS05495	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HMPREF0837_RS05500	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HMPREF0837_RS05505	COG0573	inorganic phosphate transmembrane transporter activity
HMPREF0837_RS05510	COG0581	inorganic phosphate transmembrane transporter activity
HMPREF0837_RS05515	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HMPREF0837_RS05520	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HMPREF0837_RS05525	COG0704	Plays a role in the regulation of phosphate uptake
HMPREF0837_RS05530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF0837_RS05535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HMPREF0837_RS05540	COG3527	Alpha-acetolactate decarboxylase
HMPREF0837_RS05555	COG3842	ATPase activity
HMPREF0837_RS05595	COG1131	(ABC) transporter
HMPREF0837_RS05605	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HMPREF0837_RS05630	COG0287	Prephenate dehydrogenase
HMPREF0837_RS05645	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HMPREF0837_RS05650	COG0077	Prephenate dehydratase
HMPREF0837_RS05660	COG3475	LICD family
HMPREF0837_RS05670	COG1215	transferase activity, transferring glycosyl groups
HMPREF0837_RS05705	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMPREF0837_RS05705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMPREF0837_RS05710	COG1132	(ABC) transporter
HMPREF0837_RS05720	COG0402	S-adenosylhomocysteine deaminase activity
HMPREF0837_RS05740	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HMPREF0837_RS05750	COG3335	DDE superfamily endonuclease
HMPREF0837_RS05765	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HMPREF0837_RS05770	COG0716	FMN binding
HMPREF0837_RS05775	COG1605	Chorismate mutase
HMPREF0837_RS05775	COG0077	Prephenate dehydratase
HMPREF0837_RS05780	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HMPREF0837_RS05785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HMPREF0837_RS05810	COG1078	dGTPase activity
HMPREF0837_RS05825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HMPREF0837_RS05840	COG1704	LemA family
HMPREF0837_RS05850	COG0488	(ABC) transporter
HMPREF0837_RS05860	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HMPREF0837_RS05875	COG0505	Belongs to the CarA family
HMPREF0837_RS05885	COG3475	LICD family
HMPREF0837_RS05890	COG3475	LICD family
HMPREF0837_RS05905	COG1063	alcohol dehydrogenase
HMPREF0837_RS05920	COG4750	Nucleotidyl transferase
HMPREF0837_RS05925	COG0758	DNA mediated transformation
HMPREF0837_RS05935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HMPREF0837_RS05940	COG2832	Protein of unknown function (DUF454)
HMPREF0837_RS05945	COG3142	Participates in the control of copper homeostasis
HMPREF0837_RS05965	COG0473	3-isopropylmalate dehydrogenase activity
HMPREF0837_RS05975	COG0066	3-isopropylmalate dehydratase activity
HMPREF0837_RS05990	COG1401	restriction endodeoxyribonuclease activity
HMPREF0837_RS06015	COG1196	nuclear chromosome segregation
HMPREF0837_RS06020	COG0561	phosphatase activity
HMPREF0837_RS06025	COG0561	phosphatase activity
HMPREF0837_RS06030	COG0552	protein localization to endoplasmic reticulum
HMPREF0837_RS06035	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HMPREF0837_RS06040	COG1126	abc transporter atp-binding protein
HMPREF0837_RS06045	COG0765	amino acid transport
HMPREF0837_RS06070	COG2816	NAD+ diphosphatase activity
HMPREF0837_RS06075	COG1827	regulation of RNA biosynthetic process
HMPREF0837_RS06085	COG4684	Psort location CytoplasmicMembrane, score
HMPREF0837_RS06090	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HMPREF0837_RS06105	COG1194	a g-specific adenine glycosylase
HMPREF0837_RS06110	COG0745	RESPONSE REGULATOR receiver
HMPREF0837_RS06115	COG5002	protein histidine kinase activity
HMPREF0837_RS06120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HMPREF0837_RS06135	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HMPREF0837_RS06150	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMPREF0837_RS06155	COG3764	Sortase (surface protein transpeptidase)
HMPREF0837_RS06175	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HMPREF0837_RS06210	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HMPREF0837_RS06215	COG1438	arginine binding
HMPREF0837_RS06220	COG0497	DNA recombination
HMPREF0837_RS06225	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HMPREF0837_RS06285	COG3684	Belongs to the aldolase LacD family
HMPREF0837_RS06290	COG3711	transcriptional antiterminator
HMPREF0837_RS06305	COG2723	6-phospho-beta-galactosidase activity
HMPREF0837_RS06320	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMPREF0837_RS06325	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMPREF0837_RS06330	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HMPREF0837_RS06335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF0837_RS06350	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HMPREF0837_RS06355	COG1011	Hydrolase
HMPREF0837_RS06370	COG1051	belongs to the nudix hydrolase family
HMPREF0837_RS06375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HMPREF0837_RS06385	COG0534	Mate efflux family protein
HMPREF0837_RS06390	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HMPREF0837_RS06395	COG0022	dehydrogenase e1 component
HMPREF0837_RS06400	COG0508	dehydrogenase complex catalyzes the overall conversion of
HMPREF0837_RS06405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMPREF0837_RS06410	COG0095	Lipoate-protein ligase
HMPREF0837_RS06430	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HMPREF0837_RS06435	COG3583	domain protein
HMPREF0837_RS06435	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HMPREF0837_RS06490	COG0560	Phosphoserine phosphatase
HMPREF0837_RS06500	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HMPREF0837_RS06510	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HMPREF0837_RS06515	COG1012	belongs to the aldehyde dehydrogenase family
HMPREF0837_RS06525	COG1523	belongs to the glycosyl hydrolase 13 family
HMPREF0837_RS06545	COG0488	(ABC) transporter
HMPREF0837_RS06555	COG1307	EDD domain protein, DegV family
HMPREF0837_RS06560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HMPREF0837_RS06565	COG0196	riboflavin kinase activity
HMPREF0837_RS06615	COG0280	phosphate acetyltransferase
HMPREF0837_RS06620	COG0564	pseudouridine synthase activity
HMPREF0837_RS06630	COG2357	RelA SpoT domain protein
HMPREF0837_RS06640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HMPREF0837_RS06645	COG1104	cysteine desulfurase activity
HMPREF0837_RS06665	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HMPREF0837_RS06675	COG0210	DNA helicase
HMPREF0837_RS06695	COG0024	Methionine aminopeptidase
HMPREF0837_RS06700	COG4109	DRTGG domain
HMPREF0837_RS06710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HMPREF0837_RS06750	COG0438	transferase activity, transferring glycosyl groups
HMPREF0837_RS06755	COG0438	transferase activity, transferring glycosyl groups
HMPREF0837_RS06760	COG2151	metal-sulfur cluster biosynthetic enzyme
HMPREF0837_RS06765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMPREF0837_RS06770	COG0358	DNA primase activity
HMPREF0837_RS06790	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HMPREF0837_RS06795	COG0772	Belongs to the SEDS family
HMPREF0837_RS06840	COG1597	lipid kinase activity
HMPREF0837_RS06915	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF0837_RS06920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF0837_RS06940	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HMPREF0837_RS06950	COG0741	lytic transglycosylase activity
HMPREF0837_RS06975	COG2890	protein-(glutamine-N5) methyltransferase activity
HMPREF0837_RS06985	COG1435	thymidine kinase activity
HMPREF0837_RS06990	COG1942	4-Oxalocrotonate Tautomerase
HMPREF0837_RS07005	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HMPREF0837_RS07015	COG4708	membrane
HMPREF0837_RS07025	COG1970	mechanosensitive ion channel activity
HMPREF0837_RS07040	COG4509	Sortase family
HMPREF0837_RS07050	COG0681	Belongs to the peptidase S26 family
HMPREF0837_RS07100	COG3443	Belongs to the bacterial solute-binding protein 9 family
HMPREF0837_RS07100	COG0803	Belongs to the bacterial solute-binding protein 9 family
HMPREF0837_RS07105	COG0531	amino acid
HMPREF0837_RS07110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HMPREF0837_RS07115	COG0785	Cytochrome C biogenesis protein
HMPREF0837_RS07150	COG0584	glycerophosphoryl diester phosphodiesterase
HMPREF0837_RS07155	COG2176	DNA-directed DNA polymerase activity
HMPREF0837_RS07165	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HMPREF0837_RS07175	COG0494	nUDIX hydrolase
HMPREF0837_RS07195	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HMPREF0837_RS07220	COG4122	O-methyltransferase activity
HMPREF0837_RS07235	COG3615	Tellurite resistance protein tehB
HMPREF0837_RS07235	COG0500	methyltransferase
HMPREF0837_RS07245	COG0557	exoribonuclease II activity
HMPREF0837_RS07260	COG2814	Major facilitator Superfamily
HMPREF0837_RS07265	COG0237	dephospho-CoA kinase activity
HMPREF0837_RS07270	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HMPREF0837_RS07280	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HMPREF0837_RS07290	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HMPREF0837_RS07295	COG4193	domain, Protein
HMPREF0837_RS07295	COG5263	repeat protein
HMPREF0837_RS07300	COG0167	dihydroorotate dehydrogenase activity
HMPREF0837_RS07305	COG0543	2 iron, 2 sulfur cluster binding
HMPREF0837_RS07335	COG1131	(ABC) transporter
HMPREF0837_RS07345	COG0658	competence protein
HMPREF0837_RS07345	COG2333	competence protein COMEC
HMPREF0837_RS07350	COG1555	photosystem II stabilization
HMPREF0837_RS07350	COG1596	polysaccharide export
HMPREF0837_RS07355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HMPREF0837_RS07360	COG0686	Belongs to the AlaDH PNT family
HMPREF0837_RS07365	COG0686	Belongs to the AlaDH PNT family
HMPREF0837_RS07370	COG0686	Belongs to the AlaDH PNT family
HMPREF0837_RS07385	COG1702	phosphate starvation-inducible protein PhoH
HMPREF0837_RS07395	COG2996	Protein conserved in bacteria
HMPREF0837_RS07405	COG0528	UMP kinase activity
HMPREF0837_RS07425	COG0470	DNA polymerase III
HMPREF0837_RS07435	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HMPREF0837_RS07450	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HMPREF0837_RS07455	COG0564	pseudouridine synthase activity
HMPREF0837_RS07460	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HMPREF0837_RS07465	COG0583	DNA-binding transcription factor activity
HMPREF0837_RS07485	COG0561	phosphatase activity
HMPREF0837_RS07490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HMPREF0837_RS07510	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HMPREF0837_RS07525	COG1982	Orn Lys Arg decarboxylase major
HMPREF0837_RS07540	COG0577	efflux transmembrane transporter activity
HMPREF0837_RS07545	COG1136	(ABC) transporter
HMPREF0837_RS07565	COG2183	response to ionizing radiation
HMPREF0837_RS07575	COG0701	Predicted permease
HMPREF0837_RS07580	COG3689	TIGRFAM TIGR03943 family protein
HMPREF0837_RS07620	COG0469	pyruvate kinase activity
HMPREF0837_RS07640	COG1438	arginine binding
HMPREF0837_RS07650	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HMPREF0837_RS07710	COG1104	cysteine desulfurase activity
HMPREF0837_RS07720	COG0697	spore germination
HMPREF0837_RS07720	COG1674	ftsk spoiiie
HMPREF0837_RS07725	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF0837_RS07725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF0837_RS07725	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF0837_RS07730	COG1105	Belongs to the carbohydrate kinase PfkB family
HMPREF0837_RS07735	COG1349	DNA-binding transcription factor activity
HMPREF0837_RS07745	COG0628	permease
HMPREF0837_RS07750	COG1686	Belongs to the peptidase S11 family
HMPREF0837_RS07760	COG0719	Fe-S assembly protein
HMPREF0837_RS07770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HMPREF0837_RS07775	COG0719	Fe-S assembly protein
HMPREF0837_RS07790	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HMPREF0837_RS07795	COG1956	GAF domain-containing protein
HMPREF0837_RS07800	COG0539	negative regulation of cytoplasmic translation
HMPREF0837_RS07835	COG4166	transmembrane transport
HMPREF0837_RS07840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HMPREF0837_RS07845	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMPREF0837_RS07855	COG0187	DNA topoisomerase II activity
HMPREF0837_RS07865	COG2801	Transposase and inactivated derivatives
HMPREF0837_RS07880	COG1079	Belongs to the binding-protein-dependent transport system permease family
HMPREF0837_RS07885	COG4603	Belongs to the binding-protein-dependent transport system permease family
HMPREF0837_RS07890	COG3845	ABC transporter
HMPREF0837_RS07895	COG1744	ABC transporter substrate-binding protein PnrA-like
HMPREF0837_RS07900	COG0295	cytidine deaminase activity
HMPREF0837_RS07910	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HMPREF0837_RS07915	COG2813	Specifically methylates the guanine in position
HMPREF0837_RS07960	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HMPREF0837_RS07980	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HMPREF0837_RS07985	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HMPREF0837_RS07990	COG1126	abc transporter atp-binding protein
HMPREF0837_RS07995	COG0765	amino acid transport
HMPREF0837_RS08000	COG4703	Protein of unknown function (DUF1797)
HMPREF0837_RS08005	COG0542	response to heat
HMPREF0837_RS08020	COG0494	nUDIX hydrolase
HMPREF0837_RS08030	COG2801	Transposase and inactivated derivatives
HMPREF0837_RS08050	COG3335	DDE superfamily endonuclease
HMPREF0837_RS08065	COG0187	DNA topoisomerase II activity
HMPREF0837_RS08075	COG0693	protein deglycase activity
HMPREF0837_RS08080	COG0772	Belongs to the SEDS family
HMPREF0837_RS08105	COG5002	protein histidine kinase activity
HMPREF0837_RS08110	COG0745	RESPONSE REGULATOR receiver
HMPREF0837_RS08135	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF0837_RS08145	COG4989	oxidoreductase activity
HMPREF0837_RS08165	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPREF0837_RS08165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPREF0837_RS08170	COG0577	efflux transmembrane transporter activity
HMPREF0837_RS08175	COG1136	(ABC) transporter
HMPREF0837_RS08180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HMPREF0837_RS08185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMPREF0837_RS08190	COG1268	BioY protein
HMPREF0837_RS08200	COG4443	Transcriptional Coactivator p15 (PC4)
HMPREF0837_RS08210	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HMPREF0837_RS08210	COG1328	CTP reductase activity
HMPREF0837_RS08240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HMPREF0837_RS08275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HMPREF0837_RS08285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF0837_RS08290	COG1126	abc transporter atp-binding protein
HMPREF0837_RS08300	COG0457	Tetratricopeptide repeat
HMPREF0837_RS08305	COG0628	permease
HMPREF0837_RS08310	COG2706	6-phosphogluconolactonase activity
HMPREF0837_RS08375	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HMPREF0837_RS08400	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HMPREF0837_RS08405	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HMPREF0837_RS08410	COG0626	cystathionine gamma-synthase activity
HMPREF0837_RS08415	COG1132	(ABC) transporter
HMPREF0837_RS08420	COG1132	(ABC) transporter
HMPREF0837_RS08430	COG4166	transmembrane transport
HMPREF0837_RS08435	COG2244	polysaccharide biosynthetic process
HMPREF0837_RS08440	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HMPREF0837_RS08465	COG2827	Endonuclease containing a URI domain
HMPREF0837_RS08470	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HMPREF0837_RS08475	COG1098	S1 RNA binding domain
HMPREF0837_RS08485	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HMPREF0837_RS08490	COG0629	single-stranded DNA binding
HMPREF0837_RS08500	COG0017	Asparaginyl-tRNA synthetase
HMPREF0837_RS08510	COG0436	Aminotransferase
HMPREF0837_RS08535	COG3711	transcriptional antiterminator
HMPREF0837_RS08555	COG0242	peptide deformylase activity
HMPREF0837_RS08560	COG0625	glutathione transferase activity
HMPREF0837_RS08570	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HMPREF0837_RS08575	COG0488	(ABC) transporter
HMPREF0837_RS08580	COG0617	tRNA 3'-terminal CCA addition
HMPREF0837_RS08590	COG1307	EDD domain protein, DegV family
HMPREF0837_RS08610	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HMPREF0837_RS08625	COG1481	regulation of sporulation
HMPREF0837_RS08630	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HMPREF0837_RS08640	COG0251	oxidation-reduction process
HMPREF0837_RS08660	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HMPREF0837_RS08670	COG4193	domain, Protein
HMPREF0837_RS08670	COG5263	repeat protein
HMPREF0837_RS08680	COG3935	DnaD domain protein
HMPREF0837_RS08695	COG2226	methyltransferase
HMPREF0837_RS08705	COG3842	ATPase activity
HMPREF0837_RS08715	COG1335	isochorismatase
HMPREF0837_RS08725	COG0513	Belongs to the DEAD box helicase family
HMPREF0837_RS08730	COG2223	nitrite transmembrane transporter activity
HMPREF0837_RS08735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMPREF0837_RS08740	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HMPREF0837_RS08745	COG3442	glutamine amidotransferase
HMPREF0837_RS08750	COG0006	proline dipeptidase activity
HMPREF0837_RS08755	COG2801	Transposase and inactivated derivatives
HMPREF0837_RS08770	COG4720	Psort location CytoplasmicMembrane, score
HMPREF0837_RS08775	COG0351	phosphomethylpyrimidine kinase
HMPREF0837_RS08800	COG2824	Alkylphosphonate utilization operon protein PhnA
HMPREF0837_RS08820	COG0463	Glycosyl transferase, family 2
HMPREF0837_RS08825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HMPREF0837_RS08835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HMPREF0837_RS08840	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HMPREF0837_RS08845	COG2384	SAM-dependent methyltransferase
HMPREF0837_RS08860	COG2801	Transposase and inactivated derivatives
HMPREF0837_RS08870	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HMPREF0837_RS08875	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF0837_RS08875	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HMPREF0837_RS08875	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF0837_RS08880	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF0837_RS08900	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HMPREF0837_RS08905	COG0204	Acyl-transferase
HMPREF0837_RS08920	COG2910	NAD(P)H-binding
HMPREF0837_RS08945	COG5002	protein histidine kinase activity
HMPREF0837_RS08950	COG0745	RESPONSE REGULATOR receiver
HMPREF0837_RS08965	COG1959	2 iron, 2 sulfur cluster binding
HMPREF0837_RS09030	COG3590	peptidase
HMPREF0837_RS09045	COG0803	Belongs to the bacterial solute-binding protein 9 family
HMPREF0837_RS09050	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HMPREF0837_RS09060	COG0577	efflux transmembrane transporter activity
HMPREF0837_RS09060	COG1136	(ABC) transporter
HMPREF0837_RS09105	COG3599	regulation of cell shape
HMPREF0837_RS09125	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HMPREF0837_RS09145	COG1051	belongs to the nudix hydrolase family
HMPREF0837_RS09150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HMPREF0837_RS09165	COG0768	penicillin binding
HMPREF0837_RS09180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HMPREF0837_RS09200	COG2731	YhcH YjgK YiaL family protein
HMPREF0837_RS09205	COG0395	ABC-type sugar transport system, permease component
HMPREF0837_RS09210	COG1175	transmembrane transport
HMPREF0837_RS09220	COG1263	PTS System
HMPREF0837_RS09220	COG2190	(PTS) system
HMPREF0837_RS09220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF0837_RS09230	COG0673	inositol 2-dehydrogenase activity
HMPREF0837_RS09235	COG4409	exo-alpha-(2->6)-sialidase activity
HMPREF0837_RS09245	COG1175	transmembrane transport
HMPREF0837_RS09250	COG1653	transport
HMPREF0837_RS09275	COG3458	cephalosporin-C deacetylase activity
HMPREF0837_RS09280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HMPREF0837_RS09295	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HMPREF0837_RS09300	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HMPREF0837_RS09315	COG1131	(ABC) transporter
HMPREF0837_RS09345	COG0778	Nitroreductase
HMPREF0837_RS09350	COG1484	DNA-dependent DNA replication
HMPREF0837_RS09365	COG1725	Transcriptional regulator
HMPREF0837_RS09370	COG1131	(ABC) transporter
HMPREF0837_RS09380	COG1668	transmembrane transport
HMPREF0837_RS09385	COG4152	abc transporter atp-binding protein
HMPREF0837_RS09405	COG1940	carbohydrate kinase activity
HMPREF0837_RS09410	COG2190	(PTS) system
HMPREF0837_RS09410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF0837_RS09410	COG1263	PTS System
HMPREF0837_RS09415	COG1621	beta-fructofuranosidase activity
HMPREF0837_RS09420	COG1609	Transcriptional regulator
HMPREF0837_RS09430	COG3425	synthase
HMPREF0837_RS09460	COG2815	serine threonine protein kinase
HMPREF0837_RS09460	COG0515	serine threonine protein kinase
HMPREF0837_RS09465	COG0631	protein serine/threonine phosphatase activity
HMPREF0837_RS09470	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HMPREF0837_RS09470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HMPREF0837_RS09480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HMPREF0837_RS09490	COG0194	GDP metabolic process
HMPREF0837_RS09510	COG2226	methyltransferase
HMPREF0837_RS09515	COG0799	negative regulation of ribosome biogenesis
HMPREF0837_RS09525	COG1713	HD superfamily hydrolase involved in NAD metabolism
HMPREF0837_RS09530	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HMPREF0837_RS09535	COG1534	Rna-binding protein
HMPREF0837_RS09540	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HMPREF0837_RS09555	COG0668	transmembrane transport
HMPREF0837_RS09580	COG3118	belongs to the thioredoxin family
HMPREF0837_RS09585	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HMPREF0837_RS09595	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HMPREF0837_RS09615	COG1164	Oligoendopeptidase f
HMPREF0837_RS09620	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HMPREF0837_RS09680	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HMPREF0837_RS09690	COG1621	beta-fructofuranosidase activity
HMPREF0837_RS09695	COG1653	transport
HMPREF0837_RS09700	COG0395	ABC-type sugar transport system, permease component
HMPREF0837_RS09705	COG4209	transmembrane transport
HMPREF0837_RS09715	COG3711	transcriptional antiterminator
HMPREF0837_RS09740	COG3237	CsbD-like
HMPREF0837_RS09755	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HMPREF0837_RS09795	COG0512	Glutamine amidotransferase of anthranilate synthase
HMPREF0837_RS09800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HMPREF0837_RS09825	COG1285	pathogenesis
HMPREF0837_RS09830	COG1178	ABC-type Fe3 transport system permease component
HMPREF0837_RS09850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HMPREF0837_RS09855	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HMPREF0837_RS09860	COG0704	Plays a role in the regulation of phosphate uptake
HMPREF0837_RS09875	COG5434	Belongs to the glycosyl hydrolase 28 family
HMPREF0837_RS09880	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HMPREF0837_RS09885	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HMPREF0837_RS09890	COG1132	(ABC) transporter
HMPREF0837_RS09895	COG1132	(ABC) transporter
HMPREF0837_RS09915	COG0708	Exodeoxyribonuclease III
HMPREF0837_RS09935	COG2233	PERMEase
HMPREF0837_RS09960	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HMPREF0837_RS09965	COG1609	Transcriptional regulator
HMPREF0837_RS09970	COG1063	alcohol dehydrogenase
HMPREF0837_RS09975	COG0789	Transcriptional regulator
HMPREF0837_RS09980	COG1230	cation diffusion facilitator family transporter
HMPREF0837_RS09990	COG3201	nicotinamide mononucleotide transporter
HMPREF0837_RS09995	COG1174	glycine betaine transport
HMPREF0837_RS10020	COG1363	Peptidase, m42
HMPREF0837_RS10035	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF0837_RS10040	COG4605	iron ion homeostasis
HMPREF0837_RS10045	COG4604	ABC transporter, ATP-binding protein
HMPREF0837_RS10050	COG4607	ABC-type enterochelin transport system periplasmic component
HMPREF0837_RS10060	COG1187	pseudouridine synthase activity
HMPREF0837_RS10080	COG0517	IMP dehydrogenase activity
HMPREF0837_RS10090	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HMPREF0837_RS10105	COG0366	Alpha amylase catalytic
HMPREF0837_RS10110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF0837_RS10110	COG1263	PTS System
HMPREF0837_RS10115	COG2188	Transcriptional regulator
HMPREF0837_RS10145	COG4608	Belongs to the ABC transporter superfamily
HMPREF0837_RS10150	COG0444	Belongs to the ABC transporter superfamily
HMPREF0837_RS10155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF0837_RS10160	COG0601	transmembrane transport
HMPREF0837_RS10165	COG4166	transmembrane transport
HMPREF0837_RS10175	COG0366	Alpha amylase catalytic
HMPREF0837_RS10185	COG0395	ABC-type sugar transport system, permease component
HMPREF0837_RS10190	COG1175	transmembrane transport
HMPREF0837_RS10195	COG1653	transport
HMPREF0837_RS10200	COG3345	alpha-galactosidase
HMPREF0837_RS10205	COG2207	Transcriptional regulator
HMPREF0837_RS10210	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HMPREF0837_RS10210	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HMPREF0837_RS10325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HMPREF0837_RS10375	COG4221	oxidoreductase activity
HMPREF0837_RS10380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPREF0837_RS10385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HMPREF0837_RS10430	COG1132	(ABC) transporter
HMPREF0837_RS10485	COG3842	ATPase activity
HMPREF0837_RS10490	COG1178	ABC-type Fe3 transport system permease component
HMPREF0837_RS10495	COG1285	pathogenesis
HMPREF0837_RS10555	COG5263	repeat protein
HMPREF0837_RS10555	COG5632	N-Acetylmuramoyl-L-alanine amidase
HMPREF0837_RS10575	COG1316	TRANSCRIPTIONal
HMPREF0837_RS10585	COG0802	atpase or kinase
HMPREF0837_RS10615	COG1674	ftsk spoiiie
HMPREF0837_RS10620	COG2946	Replication initiation factor
HMPREF0837_RS10670	COG0791	NLP P60 protein
HMPREF0837_RS10670	COG0741	lytic transglycosylase activity
HMPREF0837_RS10710	COG0488	(ABC) transporter
HMPREF0837_RS10760	COG0577	efflux transmembrane transporter activity
HMPREF0837_RS10760	COG1136	(ABC) transporter
HMPREF0837_RS10790	COG1253	flavin adenine dinucleotide binding
HMPREF0837_RS10805	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HMPREF0837_RS10815	COG3480	Lon protease (S16) C-terminal proteolytic domain
HMPREF0837_RS10825	COG0742	ribosomal rna small subunit methyltransferase
HMPREF0837_RS10845	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HMPREF0837_RS10850	COG1254	Belongs to the acylphosphatase family
HMPREF0837_RS10860	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HMPREF0837_RS10870	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HMPREF0837_RS10885	COG1564	THIamine pyrophosphokinase
HMPREF0837_RS10895	COG1162	GTPase activity
HMPREF0837_RS10920	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HMPREF0837_RS10925	COG0084	hydrolase, TatD family'
HMPREF0837_RS10940	COG0436	Aminotransferase
HMPREF0837_RS10950	COG0589	response to stress
HMPREF0837_RS10955	COG0561	phosphatase activity
HMPREF0837_RS10960	COG0252	asparaginase activity
HMPREF0837_RS10970	COG1609	Transcriptional regulator
HMPREF0837_RS10975	COG2197	response regulator
HMPREF0837_RS10980	COG4585	Histidine kinase
HMPREF0837_RS10985	COG0842	Transport permease protein
HMPREF0837_RS10990	COG1131	(ABC) transporter
HMPREF0837_RS11085	COG2274	protein secretion by the type I secretion system
HMPREF0837_RS11090	COG2274	protein secretion by the type I secretion system