locus-tag	class	description
SP_RS00010	COG0592	DNA-directed DNA polymerase activity
SP_RS00020	COG0012	GTP binding
SP_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SP_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SP_RS00055	COG0037	tRNA processing
SP_RS00060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SP_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SP_RS00145	COG0756	dUTP diphosphatase activity
SP_RS00155	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SP_RS00175	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SP_RS00195	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SP_RS00195	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SP_RS00200	COG1832	CoA-binding protein
SP_RS00210	COG2855	membrane
SP_RS00215	COG0436	Aminotransferase
SP_RS00230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SP_RS00255	COG2274	protein secretion by the type I secretion system
SP_RS00260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SP_RS00265	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SP_RS00270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SP_RS00275	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SP_RS00280	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SP_RS00285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SP_RS00300	COG0151	Belongs to the GarS family
SP_RS00305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SP_RS00320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SP_RS00325	COG3583	domain protein
SP_RS00325	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SP_RS00325	COG3064	Membrane
SP_RS00340	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SP_RS00345	COG3715	PTS system
SP_RS00350	COG3716	PTS system mannose fructose sorbose family IID component
SP_RS00360	COG2222	sugar isomerase
SP_RS00380	COG3583	domain protein
SP_RS00385	COG2514	catechol 2,3-dioxygenase activity
SP_RS00390	COG0110	maltose O-acetyltransferase activity
SP_RS00405	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SP_RS00410	COG0569	domain protein
SP_RS00415	COG1215	transferase activity, transferring glycosyl groups
SP_RS00435	COG5002	protein histidine kinase activity
SP_RS00460	COG4209	transmembrane transport
SP_RS00465	COG0395	ABC-type sugar transport system, permease component
SP_RS00475	COG1653	transport
SP_RS00505	COG1695	Transcriptional regulator
SP_RS00530	COG0546	phosphoglycolate phosphatase activity
SP_RS00535	COG1760	l-serine dehydratase
SP_RS00540	COG1760	l-serine dehydratase
SP_RS00570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SP_RS00605	COG0494	nUDIX hydrolase
SP_RS00610	COG0445	tRNA wobble uridine modification
SP_RS00645	COG1214	PFAM Peptidase M22, glycoprotease
SP_RS00655	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SP_RS00690	COG0438	transferase activity, transferring glycosyl groups
SP_RS00725	COG1396	sequence-specific DNA binding
SP_RS00765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SP_RS00770	COG1464	Belongs to the NlpA lipoprotein family
SP_RS00775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SP_RS00780	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SP_RS00800	COG2972	Histidine kinase
SP_RS00805	COG2207	Transcriptional regulator
SP_RS00805	COG4753	response regulator
SP_RS00815	COG1780	Probably involved in ribonucleotide reductase function
SP_RS00845	COG0019	diaminopimelate decarboxylase activity
SP_RS00875	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SP_RS00875	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SP_RS00895	COG2818	Glycosylase
SP_RS00920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SP_RS00925	COG0006	proline dipeptidase activity
SP_RS00930	COG1393	Belongs to the ArsC family
SP_RS00955	COG0285	dihydrofolate synthase activity
SP_RS00965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SP_RS00980	COG1328	CTP reductase activity
SP_RS01030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SP_RS01055	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SP_RS01085	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SP_RS01095	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SP_RS01110	COG0201	protein transport
SP_RS01120	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SP_RS01125	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SP_RS01135	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SP_RS01140	COG0202	RNA polymerase activity
SP_RS01145	COG0203	ribosomal protein L17
SP_RS01150	COG3830	Belongs to the UPF0237 family
SP_RS01155	COG2848	UPF0210 protein
SP_RS01180	COG3842	ATPase activity
SP_RS01190	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SP_RS01195	COG1349	DNA-binding transcription factor activity
SP_RS01205	COG1447	Phosphotransferase system cellobiose-specific component IIA
SP_RS01210	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SP_RS01215	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SP_RS01220	COG1882	Formate acetyltransferase
SP_RS01235	COG0495	leucyl-tRNA aminoacylation
SP_RS01255	COG3344	reverse transcriptase
SP_RS01270	COG2255	four-way junction helicase activity
SP_RS01280	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SP_RS01285	COG4589	Belongs to the CDS family
SP_RS01290	COG0750	zinc metalloprotease
SP_RS01295	COG0442	prolyl-tRNA aminoacylation
SP_RS01300	COG2723	6-phospho-beta-galactosidase activity
SP_RS01305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SP_RS01315	COG1523	belongs to the glycosyl hydrolase 13 family
SP_RS01325	COG0049	tRNA binding
SP_RS01335	COG2176	DNA-directed DNA polymerase activity
SP_RS01355	COG2309	aminopeptidase activity
SP_RS01360	COG2261	transglycosylase associated protein
SP_RS01370	COG1187	pseudouridine synthase activity
SP_RS01380	COG3579	cysteine-type endopeptidase activity
SP_RS01385	COG3716	PTS system mannose fructose sorbose family IID component
SP_RS01390	COG3715	PTS system
SP_RS01400	COG1064	alcohol dehydrogenase
SP_RS01405	COG0561	phosphatase activity
SP_RS01410	COG2252	PERMEase
SP_RS01420	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SP_RS01425	COG0285	dihydrofolate synthase activity
SP_RS01435	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SP_RS01435	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SP_RS01445	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SP_RS01455	COG1373	ATPase (AAA superfamily
SP_RS01480	COG2723	6-phospho-beta-galactosidase activity
SP_RS01510	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SP_RS01525	COG0386	Belongs to the glutathione peroxidase family
SP_RS01530	COG5492	domain, Protein
SP_RS01555	COG1028	Short-chain dehydrogenase reductase Sdr
SP_RS01565	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SP_RS01570	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SP_RS01575	COG3715	PTS system
SP_RS01580	COG3716	PTS system mannose fructose sorbose family IID component
SP_RS01605	COG1609	Transcriptional regulator
SP_RS01630	COG0275	rRNA processing
SP_RS01635	COG4839	cell division protein FtsL
SP_RS01640	COG0768	penicillin binding
SP_RS01665	COG0366	Alpha amylase catalytic
SP_RS01695	COG4464	protein tyrosine phosphatase activity
SP_RS01700	COG3944	biosynthesis protein
SP_RS01705	COG0489	protein tyrosine kinase activity
SP_RS01710	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SP_RS01725	COG0438	transferase activity, transferring glycosyl groups
SP_RS01745	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SP_RS01760	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SP_RS01765	COG4372	Transposase
SP_RS01775	COG3335	DDE superfamily endonuclease
SP_RS01790	COG4166	transmembrane transport
SP_RS01795	COG0366	Alpha amylase catalytic
SP_RS01800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SP_RS01825	COG0116	Belongs to the methyltransferase superfamily
SP_RS01835	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SP_RS01840	COG0745	RESPONSE REGULATOR receiver
SP_RS01895	COG4585	Histidine kinase
SP_RS01900	COG2197	response regulator
SP_RS01935	COG2801	Transposase and inactivated derivatives
SP_RS01955	COG2213	PTS system mannitol-specific
SP_RS01960	COG3711	transcriptional antiterminator
SP_RS01965	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SP_RS01970	COG0246	Mannitol dehydrogenase
SP_RS01985	COG0544	peptidyl-prolyl cis-trans isomerase activity
SP_RS01990	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SP_RS01995	COG0681	Belongs to the peptidase S26 family
SP_RS02000	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SP_RS02015	COG1193	negative regulation of DNA recombination
SP_RS02020	COG1115	amino acid carrier protein
SP_RS02045	COG0527	aspartate kinase activity
SP_RS02050	COG1024	Enoyl-CoA hydratase
SP_RS02055	COG1846	Transcriptional regulator
SP_RS02065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SP_RS02075	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SP_RS02080	COG1028	Short-chain dehydrogenase reductase Sdr
SP_RS02085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SP_RS02095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SP_RS02100	COG0439	Biotin carboxylase
SP_RS02105	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SP_RS02165	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SP_RS02175	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SP_RS02185	COG1461	Dihydroxyacetone kinase
SP_RS02190	COG0028	Belongs to the TPP enzyme family
SP_RS02195	COG0440	acetolactate synthase activity
SP_RS02215	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SP_RS02230	COG0765	amino acid transport
SP_RS02260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SP_RS02265	COG1882	Formate acetyltransferase
SP_RS02335	COG1846	Transcriptional regulator
SP_RS02335	COG1940	carbohydrate kinase activity
SP_RS02340	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SP_RS02350	COG1447	Phosphotransferase system cellobiose-specific component IIA
SP_RS02355	COG2723	6-phospho-beta-galactosidase activity
SP_RS02360	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SP_RS02360	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SP_RS02365	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SP_RS02370	COG0569	domain protein
SP_RS02390	COG1122	ATPase activity
SP_RS02405	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SP_RS02410	COG0671	phosphoesterase, PA-phosphatase related
SP_RS02435	COG0504	CTP synthase activity
SP_RS02445	COG1283	sodium-dependent phosphate transmembrane transporter activity
SP_RS02455	COG0126	phosphoglycerate kinase activity
SP_RS02465	COG0789	Transcriptional regulator
SP_RS02470	COG0174	glutamine synthetase
SP_RS02485	COG4974	Belongs to the 'phage' integrase family
SP_RS02495	COG0732	type I restriction modification DNA specificity domain
SP_RS02525	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SP_RS02540	COG0484	heat shock protein binding
SP_RS02550	COG0537	adenosine 5'-monophosphoramidase activity
SP_RS02555	COG1131	(ABC) transporter
SP_RS02580	COG3290	protein histidine kinase activity
SP_RS02590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SP_RS02595	COG2274	protein secretion by the type I secretion system
SP_RS02600	COG2274	protein secretion by the type I secretion system
SP_RS02605	COG2274	protein secretion by the type I secretion system
SP_RS02695	COG1266	CAAX protease self-immunity
SP_RS02715	COG0195	Participates in both transcription termination and antitermination
SP_RS02720	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SP_RS02730	COG3064	Membrane
SP_RS02730	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SP_RS02735	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SP_RS02780	COG0519	Catalyzes the synthesis of GMP from XMP
SP_RS02790	COG0525	valine-tRNA ligase activity
SP_RS02850	COG3711	transcriptional antiterminator
SP_RS02855	COG2190	(PTS) system
SP_RS02855	COG1263	PTS System
SP_RS02855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SP_RS02870	COG0456	acetyltransferase
SP_RS02875	COG0072	phenylalanine-tRNA ligase activity
SP_RS02875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SP_RS02895	COG3620	sequence-specific DNA binding
SP_RS02900	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SP_RS02910	COG1185	polyribonucleotide nucleotidyltransferase activity
SP_RS02915	COG1045	serine acetyltransferase
SP_RS02925	COG0215	cysteine-tRNA ligase activity
SP_RS02930	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SP_RS02950	COG0577	efflux transmembrane transporter activity
SP_RS02955	COG1136	(ABC) transporter
SP_RS02960	COG0577	efflux transmembrane transporter activity
SP_RS02965	COG0745	RESPONSE REGULATOR receiver
SP_RS02970	COG5002	protein histidine kinase activity
SP_RS02975	COG0191	fructose-bisphosphate aldolase activity
SP_RS02980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SP_RS02985	COG0765	amino acid transport
SP_RS02990	COG0765	amino acid transport
SP_RS02995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SP_RS03005	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SP_RS03005	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SP_RS03035	COG0322	excinuclease ABC activity
SP_RS03045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SP_RS03060	COG1573	uracil-dna glycosylase
SP_RS03070	COG1114	Component of the transport system for branched-chain amino acids
SP_RS03075	COG1363	Peptidase, m42
SP_RS03115	COG4555	ABC transporter
SP_RS03145	COG1404	Belongs to the peptidase S8 family
SP_RS03150	COG4372	Transposase
SP_RS03165	COG3775	system Galactitol-specific IIC component
SP_RS03175	COG3250	beta-galactosidase activity
SP_RS03195	COG1242	4 iron, 4 sulfur cluster binding
SP_RS03200	COG1242	4 iron, 4 sulfur cluster binding
SP_RS03205	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SP_RS03230	COG0785	Cytochrome C biogenesis protein
SP_RS03235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SP_RS03240	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SP_RS03240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SP_RS03245	COG2207	Transcriptional regulator
SP_RS03245	COG4753	response regulator
SP_RS03250	COG2972	Histidine kinase
SP_RS03255	COG4475	Protein of unknown function (DUF436)
SP_RS03260	COG3064	Membrane
SP_RS03265	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SP_RS03280	COG1940	carbohydrate kinase activity
SP_RS03300	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SP_RS03305	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SP_RS03315	COG0300	oxidoreductase activity
SP_RS03330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SP_RS03340	COG1187	pseudouridine synthase activity
SP_RS03345	COG1217	gtp-binding protein TYPA
SP_RS03365	COG1136	(ABC) transporter
SP_RS03370	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SP_RS03375	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SP_RS03380	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SP_RS03420	COG2826	transposase and inactivated derivatives, IS30 family
SP_RS03425	COG0284	orotidine-5'-phosphate decarboxylase activity
SP_RS03430	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SP_RS03455	COG1131	(ABC) transporter
SP_RS03460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SP_RS03470	COG1126	abc transporter atp-binding protein
SP_RS03475	COG0765	amino acid transport
SP_RS03480	COG0765	amino acid transport
SP_RS03485	COG1304	FMN binding
SP_RS03490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SP_RS03500	COG1304	FMN binding
SP_RS03510	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SP_RS03515	COG0352	thiamine-phosphate diphosphorylase activity
SP_RS03525	COG4172	Belongs to the ABC transporter superfamily
SP_RS03535	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SP_RS03545	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SP_RS03550	COG0352	thiamine-phosphate diphosphorylase activity
SP_RS03570	COG2217	Heavy metal translocating P-type atpase
SP_RS03575	COG0028	Belongs to the TPP enzyme family
SP_RS03585	COG3335	DDE superfamily endonuclease
SP_RS03600	COG2723	6-phospho-beta-galactosidase activity
SP_RS03605	COG1482	cell wall glycoprotein biosynthetic process
SP_RS03610	COG0733	neurotransmitter:sodium symporter activity
SP_RS03620	COG0789	Transcriptional regulator
SP_RS03630	COG2081	HI0933 family
SP_RS03635	COG1307	EDD domain protein, DegV family
SP_RS03645	COG2131	deaminase
SP_RS03650	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SP_RS03690	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SP_RS03690	COG0617	tRNA 3'-terminal CCA addition
SP_RS03690	COG0517	IMP dehydrogenase activity
SP_RS03695	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SP_RS03700	COG2884	Cell division ATP-binding protein ftsE
SP_RS03705	COG2177	Part of the ABC transporter FtsEX involved in
SP_RS03710	COG1263	PTS System
SP_RS03710	COG2190	(PTS) system
SP_RS03710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SP_RS03720	COG0513	Belongs to the DEAD box helicase family
SP_RS03730	COG0167	dihydroorotate dehydrogenase activity
SP_RS03740	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SP_RS03745	COG4470	Protein conserved in bacteria
SP_RS03750	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SP_RS03760	COG0488	(ABC) transporter
SP_RS03785	COG1837	Belongs to the UPF0109 family
SP_RS03795	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SP_RS03805	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SP_RS03805	COG1328	CTP reductase activity
SP_RS03815	COG4443	Transcriptional Coactivator p15 (PC4)
SP_RS03825	COG1268	BioY protein
SP_RS03830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SP_RS03835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SP_RS03840	COG1136	(ABC) transporter
SP_RS03845	COG0577	efflux transmembrane transporter activity
SP_RS03850	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SP_RS03850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SP_RS03870	COG4989	oxidoreductase activity
SP_RS03880	COG1028	Short-chain dehydrogenase reductase Sdr
SP_RS03905	COG0745	RESPONSE REGULATOR receiver
SP_RS03910	COG5002	protein histidine kinase activity
SP_RS03935	COG0772	Belongs to the SEDS family
SP_RS03940	COG0693	protein deglycase activity
SP_RS03950	COG0187	DNA topoisomerase II activity
SP_RS03955	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SP_RS03965	COG3335	DDE superfamily endonuclease
SP_RS03990	COG2801	Transposase and inactivated derivatives
SP_RS04015	COG0542	response to heat
SP_RS04020	COG4703	Protein of unknown function (DUF1797)
SP_RS04025	COG0765	amino acid transport
SP_RS04030	COG1126	abc transporter atp-binding protein
SP_RS04035	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SP_RS04050	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SP_RS04055	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SP_RS04065	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SP_RS04100	COG0268	Binds directly to 16S ribosomal RNA
SP_RS04105	COG1072	(Pantothenic acid kinase))
SP_RS04115	COG2813	Specifically methylates the guanine in position
SP_RS04120	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SP_RS04130	COG0295	cytidine deaminase activity
SP_RS04135	COG1744	ABC transporter substrate-binding protein PnrA-like
SP_RS04140	COG3845	ABC transporter
SP_RS04145	COG4603	Belongs to the binding-protein-dependent transport system permease family
SP_RS04150	COG1079	Belongs to the binding-protein-dependent transport system permease family
SP_RS04165	COG2801	Transposase and inactivated derivatives
SP_RS04170	COG2801	Transposase and inactivated derivatives
SP_RS04180	COG0187	DNA topoisomerase II activity
SP_RS04190	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SP_RS04195	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SP_RS04200	COG4166	transmembrane transport
SP_RS04235	COG0539	negative regulation of cytoplasmic translation
SP_RS04255	COG1956	GAF domain-containing protein
SP_RS04260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SP_RS04275	COG0719	Fe-S assembly protein
SP_RS04280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SP_RS04290	COG0719	Fe-S assembly protein
SP_RS04300	COG1686	Belongs to the peptidase S11 family
SP_RS04305	COG0628	permease
SP_RS04315	COG1349	DNA-binding transcription factor activity
SP_RS04320	COG1105	Belongs to the carbohydrate kinase PfkB family
SP_RS04325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SP_RS04325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SP_RS04325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SP_RS04330	COG1674	ftsk spoiiie
SP_RS04330	COG0697	spore germination
SP_RS04340	COG1104	cysteine desulfurase activity
SP_RS04400	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
SP_RS04405	COG1438	arginine binding
SP_RS04425	COG0469	pyruvate kinase activity
SP_RS04465	COG3689	TIGRFAM TIGR03943 family protein
SP_RS04470	COG0701	Predicted permease
SP_RS04480	COG3955	Domain of unknown function (DUF1919)
SP_RS04485	COG2183	response to ionizing radiation
SP_RS04505	COG1136	(ABC) transporter
SP_RS04510	COG0577	efflux transmembrane transporter activity
SP_RS04525	COG1982	Orn Lys Arg decarboxylase major
SP_RS04540	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SP_RS04560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SP_RS04565	COG0561	phosphatase activity
SP_RS04585	COG0583	DNA-binding transcription factor activity
SP_RS04590	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SP_RS04595	COG0564	pseudouridine synthase activity
SP_RS04600	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SP_RS04605	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SP_RS04610	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SP_RS04615	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SP_RS04625	COG0470	DNA polymerase III
SP_RS04670	COG0528	UMP kinase activity
SP_RS04680	COG2996	Protein conserved in bacteria
SP_RS04690	COG1702	phosphate starvation-inducible protein PhoH
SP_RS04715	COG0686	Belongs to the AlaDH PNT family
SP_RS04720	COG0686	Belongs to the AlaDH PNT family
SP_RS04725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SP_RS04730	COG1555	photosystem II stabilization
SP_RS04730	COG1596	polysaccharide export
SP_RS04735	COG0658	competence protein
SP_RS04735	COG2333	competence protein COMEC
SP_RS04745	COG1131	(ABC) transporter
SP_RS04775	COG0543	2 iron, 2 sulfur cluster binding
SP_RS04780	COG0167	dihydroorotate dehydrogenase activity
SP_RS04785	COG5263	repeat protein
SP_RS04785	COG4193	domain, Protein
SP_RS04790	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SP_RS04800	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SP_RS04810	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SP_RS04815	COG0237	dephospho-CoA kinase activity
SP_RS04820	COG2814	Major facilitator Superfamily
SP_RS04825	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SP_RS04835	COG0557	exoribonuclease II activity
SP_RS04845	COG0500	methyltransferase
SP_RS04845	COG3615	Tellurite resistance protein tehB
SP_RS04860	COG4122	O-methyltransferase activity
SP_RS04870	COG2801	Transposase and inactivated derivatives
SP_RS04885	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SP_RS04900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SP_RS04905	COG0494	nUDIX hydrolase
SP_RS04915	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SP_RS04925	COG2176	DNA-directed DNA polymerase activity
SP_RS04930	COG0584	glycerophosphoryl diester phosphodiesterase
SP_RS04955	COG0785	Cytochrome C biogenesis protein
SP_RS04960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SP_RS04965	COG0531	amino acid
SP_RS04970	COG3443	Belongs to the bacterial solute-binding protein 9 family
SP_RS04970	COG0803	Belongs to the bacterial solute-binding protein 9 family
SP_RS05000	COG2195	Cleaves the N-terminal amino acid of tripeptides
SP_RS05005	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SP_RS05010	COG1970	mechanosensitive ion channel activity
SP_RS05020	COG4708	membrane
SP_RS05030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SP_RS05045	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SP_RS05050	COG1942	4-Oxalocrotonate Tautomerase
SP_RS05055	COG1435	thymidine kinase activity
SP_RS05065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SP_RS05070	COG2890	protein-(glutamine-N5) methyltransferase activity
SP_RS05085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SP_RS05095	COG0741	lytic transglycosylase activity
SP_RS05105	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SP_RS05125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SP_RS05130	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SP_RS05175	COG1597	lipid kinase activity
SP_RS05195	COG1396	sequence-specific DNA binding
SP_RS05200	COG0542	response to heat
SP_RS05205	COG0613	PHP domain protein
SP_RS05210	COG1196	nuclear chromosome segregation
SP_RS05225	COG3843	relaxase mobilization nuclease domain protein
SP_RS05245	COG0515	serine threonine protein kinase
SP_RS05250	COG1122	ATPase activity
SP_RS05265	COG1396	sequence-specific DNA binding
SP_RS05275	COG0772	Belongs to the SEDS family
SP_RS05280	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SP_RS05295	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SP_RS05300	COG0358	DNA primase activity
SP_RS05305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SP_RS05310	COG2151	metal-sulfur cluster biosynthetic enzyme
SP_RS05315	COG0438	transferase activity, transferring glycosyl groups
SP_RS05320	COG0438	transferase activity, transferring glycosyl groups
SP_RS05345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SP_RS05355	COG4109	DRTGG domain
SP_RS05360	COG0024	Methionine aminopeptidase
SP_RS05385	COG0210	DNA helicase
SP_RS05395	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SP_RS05415	COG1104	cysteine desulfurase activity
SP_RS05420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SP_RS05430	COG2357	RelA SpoT domain protein
SP_RS05440	COG0564	pseudouridine synthase activity
SP_RS05445	COG0280	phosphate acetyltransferase
SP_RS05495	COG0196	riboflavin kinase activity
SP_RS05500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SP_RS05505	COG1307	EDD domain protein, DegV family
SP_RS05515	COG0488	(ABC) transporter
SP_RS05530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SP_RS05535	COG1523	belongs to the glycosyl hydrolase 13 family
SP_RS05545	COG1012	belongs to the aldehyde dehydrogenase family
SP_RS05550	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SP_RS05560	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SP_RS05570	COG0560	Phosphoserine phosphatase
SP_RS05575	COG0560	Phosphoserine phosphatase
SP_RS05655	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
SP_RS05660	COG3620	sequence-specific DNA binding
SP_RS05680	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SP_RS05685	COG1074	ATP-dependent DNA helicase activity
SP_RS05695	COG3583	domain protein
SP_RS05695	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
SP_RS05700	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SP_RS05705	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SP_RS05715	COG4974	Belongs to the 'phage' integrase family
SP_RS05720	COG0095	Lipoate-protein ligase
SP_RS05725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SP_RS05730	COG0508	dehydrogenase complex catalyzes the overall conversion of
SP_RS05735	COG0022	dehydrogenase e1 component
SP_RS05740	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SP_RS05745	COG0534	Mate efflux family protein
SP_RS05755	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SP_RS05760	COG1051	belongs to the nudix hydrolase family
SP_RS05775	COG1011	Hydrolase
SP_RS05780	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SP_RS05800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SP_RS05805	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SP_RS05810	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SP_RS05815	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SP_RS05825	COG2723	6-phospho-beta-galactosidase activity
SP_RS05840	COG3711	transcriptional antiterminator
SP_RS05850	COG3684	Belongs to the aldolase LacD family
SP_RS05855	COG1105	Belongs to the carbohydrate kinase PfkB family
SP_RS05865	COG0698	ribose 5-phosphate isomerase
SP_RS05900	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SP_RS05905	COG0497	DNA recombination
SP_RS05910	COG1438	arginine binding
SP_RS05915	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SP_RS05950	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SP_RS05970	COG3764	Sortase (surface protein transpeptidase)
SP_RS05975	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SP_RS06005	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SP_RS06010	COG5002	protein histidine kinase activity
SP_RS06015	COG0745	RESPONSE REGULATOR receiver
SP_RS06020	COG1194	a g-specific adenine glycosylase
SP_RS06025	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SP_RS06035	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SP_RS06040	COG4684	Psort location CytoplasmicMembrane, score
SP_RS06050	COG1827	regulation of RNA biosynthetic process
SP_RS06080	COG0765	amino acid transport
SP_RS06085	COG1126	abc transporter atp-binding protein
SP_RS06090	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SP_RS06095	COG0552	protein localization to endoplasmic reticulum
SP_RS06100	COG0561	phosphatase activity
SP_RS06105	COG0561	phosphatase activity
SP_RS06110	COG1196	nuclear chromosome segregation
SP_RS06115	COG0571	ribonuclease III activity
SP_RS06125	COG0516	GMP reductase activity
SP_RS06135	COG1401	restriction endodeoxyribonuclease activity
SP_RS06150	COG0066	3-isopropylmalate dehydratase activity
SP_RS06160	COG0473	3-isopropylmalate dehydrogenase activity
SP_RS06165	COG0473	3-isopropylmalate dehydrogenase activity
SP_RS06180	COG3142	Participates in the control of copper homeostasis
SP_RS06185	COG2832	Protein of unknown function (DUF454)
SP_RS06195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SP_RS06205	COG0758	DNA mediated transformation
SP_RS06210	COG4750	Nucleotidyl transferase
SP_RS06225	COG1063	alcohol dehydrogenase
SP_RS06230	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SP_RS06240	COG3475	LICD family
SP_RS06245	COG3475	LICD family
SP_RS06255	COG0505	Belongs to the CarA family
SP_RS06270	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SP_RS06285	COG0488	(ABC) transporter
SP_RS06290	COG0501	Belongs to the peptidase M48B family
SP_RS06295	COG1704	LemA family
SP_RS06310	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SP_RS06325	COG1078	dGTPase activity
SP_RS06350	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SP_RS06355	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SP_RS06360	COG1605	Chorismate mutase
SP_RS06360	COG0077	Prephenate dehydratase
SP_RS06365	COG0716	FMN binding
SP_RS06370	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SP_RS06390	COG3335	DDE superfamily endonuclease
SP_RS06400	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SP_RS06485	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SP_RS06490	COG1269	ATP hydrolysis coupled proton transport
SP_RS06505	COG0673	inositol 2-dehydrogenase activity
SP_RS06510	COG4409	exo-alpha-(2->6)-sialidase activity
SP_RS06520	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SP_RS06525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SP_RS06530	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SP_RS06535	COG1737	Transcriptional regulator
SP_RS06580	COG0577	efflux transmembrane transporter activity
SP_RS06580	COG1136	(ABC) transporter
SP_RS06590	COG1770	oligopeptidase
SP_RS06595	COG0515	serine threonine protein kinase
SP_RS06635	COG0402	S-adenosylhomocysteine deaminase activity
SP_RS06645	COG1132	(ABC) transporter
SP_RS06650	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SP_RS06650	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SP_RS06670	COG4862	establishment of competence for transformation
SP_RS06685	COG1215	transferase activity, transferring glycosyl groups
SP_RS06695	COG3475	LICD family
SP_RS06710	COG0077	Prephenate dehydratase
SP_RS06715	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SP_RS06720	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SP_RS06725	COG3679	Belongs to the UPF0342 family
SP_RS06730	COG0287	Prephenate dehydrogenase
SP_RS06740	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SP_RS06755	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SP_RS06770	COG1131	(ABC) transporter
SP_RS06780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SP_RS06810	COG3842	ATPase activity
SP_RS06825	COG3527	Alpha-acetolactate decarboxylase
SP_RS06830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SP_RS06835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SP_RS06840	COG0704	Plays a role in the regulation of phosphate uptake
SP_RS06845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SP_RS06850	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SP_RS06855	COG0581	inorganic phosphate transmembrane transporter activity
SP_RS06860	COG0573	inorganic phosphate transmembrane transporter activity
SP_RS06865	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SP_RS06870	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SP_RS06870	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SP_RS06875	COG0483	inositol monophosphate 1-phosphatase activity
SP_RS06885	COG1393	Belongs to the ArsC family
SP_RS06895	COG0647	UMP catabolic process
SP_RS06905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SP_RS06920	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SP_RS06940	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SP_RS06970	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SP_RS06995	COG1131	(ABC) transporter
SP_RS07010	COG0826	peptidase U32
SP_RS07035	COG1132	(ABC) transporter
SP_RS07040	COG1132	(ABC) transporter
SP_RS07055	COG1129	ABC transporter
SP_RS07070	COG4372	Transposase
SP_RS07105	COG2188	Transcriptional regulator
SP_RS07110	COG0697	spore germination
SP_RS07115	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SP_RS07130	COG0561	phosphatase activity
SP_RS07165	COG0492	ferredoxin-NADP+ reductase activity
SP_RS07175	COG1126	abc transporter atp-binding protein
SP_RS07185	COG1393	Belongs to the ArsC family
SP_RS07190	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SP_RS07205	COG1272	protein, Hemolysin III
SP_RS07235	COG0431	NADPH-dependent FMN reductase
SP_RS07235	COG1053	succinate dehydrogenase
SP_RS07235	COG3976	FMN-binding domain protein
SP_RS07250	COG0752	glycyl-tRNA synthetase alpha subunit
SP_RS07260	COG0656	L-ascorbic acid biosynthetic process
SP_RS07265	COG0726	polysaccharide deacetylase
SP_RS07295	COG3335	DDE superfamily endonuclease
SP_RS07300	COG2801	Transposase and inactivated derivatives
SP_RS07340	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SP_RS07375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SP_RS07385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SP_RS07390	COG1126	abc transporter atp-binding protein
SP_RS07410	COG0628	permease
SP_RS07415	COG2706	6-phosphogluconolactonase activity
SP_RS07430	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SP_RS07470	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SP_RS07475	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SP_RS07500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SP_RS07505	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SP_RS07510	COG0626	cystathionine gamma-synthase activity
SP_RS07515	COG1132	(ABC) transporter
SP_RS07520	COG1132	(ABC) transporter
SP_RS07525	COG4166	transmembrane transport
SP_RS07530	COG2244	polysaccharide biosynthetic process
SP_RS07535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SP_RS07560	COG2827	Endonuclease containing a URI domain
SP_RS07565	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SP_RS07570	COG1098	S1 RNA binding domain
SP_RS07580	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SP_RS07585	COG0629	single-stranded DNA binding
SP_RS07595	COG0017	Asparaginyl-tRNA synthetase
SP_RS07605	COG0436	Aminotransferase
SP_RS07625	COG3022	response to hydroperoxide
SP_RS07640	COG0242	peptide deformylase activity
SP_RS07645	COG0625	glutathione transferase activity
SP_RS07655	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SP_RS07660	COG0488	(ABC) transporter
SP_RS07665	COG0617	tRNA 3'-terminal CCA addition
SP_RS07675	COG1307	EDD domain protein, DegV family
SP_RS07695	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SP_RS07710	COG1481	regulation of sporulation
SP_RS07715	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SP_RS07725	COG0251	oxidation-reduction process
SP_RS07745	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SP_RS07755	COG5263	repeat protein
SP_RS07755	COG4193	domain, Protein
SP_RS07765	COG3935	DnaD domain protein
SP_RS07770	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SP_RS07780	COG2226	methyltransferase
SP_RS07790	COG3842	ATPase activity
SP_RS07805	COG1335	isochorismatase
SP_RS07810	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SP_RS07815	COG0513	Belongs to the DEAD box helicase family
SP_RS07820	COG2223	nitrite transmembrane transporter activity
SP_RS07825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SP_RS07830	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SP_RS07835	COG3442	glutamine amidotransferase
SP_RS07840	COG0006	proline dipeptidase activity
SP_RS07845	COG2801	Transposase and inactivated derivatives
SP_RS07850	COG2801	Transposase and inactivated derivatives
SP_RS07870	COG4720	Psort location CytoplasmicMembrane, score
SP_RS07875	COG0351	phosphomethylpyrimidine kinase
SP_RS07900	COG2824	Alkylphosphonate utilization operon protein PhnA
SP_RS07905	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SP_RS07920	COG0463	Glycosyl transferase, family 2
SP_RS07925	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SP_RS07930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SP_RS07935	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SP_RS07940	COG2384	SAM-dependent methyltransferase
SP_RS07950	COG2801	Transposase and inactivated derivatives
SP_RS07955	COG2801	Transposase and inactivated derivatives
SP_RS07965	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SP_RS07970	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SP_RS07975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SP_RS07975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SP_RS07975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SP_RS07980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SP_RS08005	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SP_RS08010	COG0204	Acyl-transferase
SP_RS08025	COG2910	NAD(P)H-binding
SP_RS08040	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SP_RS08045	COG5002	protein histidine kinase activity
SP_RS08050	COG0745	RESPONSE REGULATOR receiver
SP_RS08065	COG1959	2 iron, 2 sulfur cluster binding
SP_RS08130	COG3590	peptidase
SP_RS08145	COG0803	Belongs to the bacterial solute-binding protein 9 family
SP_RS08150	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SP_RS08160	COG1136	(ABC) transporter
SP_RS08160	COG0577	efflux transmembrane transporter activity
SP_RS08190	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SP_RS08205	COG3599	regulation of cell shape
SP_RS08225	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SP_RS08245	COG1051	belongs to the nudix hydrolase family
SP_RS08250	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SP_RS08255	COG1181	Belongs to the D-alanine--D-alanine ligase family
SP_RS08265	COG0768	penicillin binding
SP_RS08280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SP_RS08300	COG2731	YhcH YjgK YiaL family protein
SP_RS08305	COG0395	ABC-type sugar transport system, permease component
SP_RS08310	COG1175	transmembrane transport
SP_RS08320	COG2190	(PTS) system
SP_RS08320	COG1263	PTS System
SP_RS08320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SP_RS08330	COG0673	inositol 2-dehydrogenase activity
SP_RS08335	COG4409	exo-alpha-(2->6)-sialidase activity
SP_RS08345	COG1175	transmembrane transport
SP_RS08350	COG1653	transport
SP_RS08380	COG3458	cephalosporin-C deacetylase activity
SP_RS08390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SP_RS08405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SP_RS08410	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SP_RS08415	COG0653	protein targeting
SP_RS08425	COG1131	(ABC) transporter
SP_RS08455	COG0778	Nitroreductase
SP_RS08460	COG1484	DNA-dependent DNA replication
SP_RS08475	COG1725	Transcriptional regulator
SP_RS08480	COG1131	(ABC) transporter
SP_RS08490	COG1668	transmembrane transport
SP_RS08495	COG4152	abc transporter atp-binding protein
SP_RS08515	COG1940	carbohydrate kinase activity
SP_RS08520	COG2190	(PTS) system
SP_RS08520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SP_RS08520	COG1263	PTS System
SP_RS08530	COG1621	beta-fructofuranosidase activity
SP_RS08535	COG1609	Transcriptional regulator
SP_RS08545	COG3425	synthase
SP_RS08570	COG2815	serine threonine protein kinase
SP_RS08570	COG0515	serine threonine protein kinase
SP_RS08575	COG0631	protein serine/threonine phosphatase activity
SP_RS08580	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SP_RS08580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SP_RS08590	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SP_RS08600	COG0194	GDP metabolic process
SP_RS08610	COG4115	mRNA cleavage
SP_RS08620	COG1323	Belongs to the UPF0348 family
SP_RS08625	COG2226	methyltransferase
SP_RS08630	COG0799	negative regulation of ribosome biogenesis
SP_RS08640	COG1713	HD superfamily hydrolase involved in NAD metabolism
SP_RS08645	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SP_RS08650	COG1534	Rna-binding protein
SP_RS08655	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SP_RS08670	COG0668	transmembrane transport
SP_RS08700	COG0438	transferase activity, transferring glycosyl groups
SP_RS08705	COG0438	transferase activity, transferring glycosyl groups
SP_RS08710	COG0653	protein targeting
SP_RS08730	COG0201	protein transport
SP_RS08735	COG1215	transferase activity, transferring glycosyl groups
SP_RS08740	COG1442	glycosyl transferase family 8
SP_RS08745	COG1442	glycosyl transferase family 8
SP_RS08750	COG1442	glycosyl transferase family 8
SP_RS08755	COG0438	transferase activity, transferring glycosyl groups
SP_RS08765	COG1442	glycosyl transferase family 8
SP_RS08765	COG1216	Glycosyl transferase, family 2
SP_RS08770	COG1442	glycosyl transferase family 8
SP_RS08775	COG1216	Glycosyl transferase, family 2
SP_RS08775	COG1442	glycosyl transferase family 8
SP_RS08805	COG3118	belongs to the thioredoxin family
SP_RS08810	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SP_RS08820	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SP_RS08835	COG1164	Oligoendopeptidase f
SP_RS08840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SP_RS08845	COG2264	protein methyltransferase activity
SP_RS08850	COG1051	belongs to the nudix hydrolase family
SP_RS08885	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SP_RS08910	COG1621	beta-fructofuranosidase activity
SP_RS08915	COG1653	transport
SP_RS08920	COG0395	ABC-type sugar transport system, permease component
SP_RS08925	COG4209	transmembrane transport
SP_RS08935	COG3711	transcriptional antiterminator
SP_RS08960	COG3237	CsbD-like
SP_RS08975	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SP_RS08990	COG0159	tryptophan synthase activity
SP_RS09015	COG0512	Glutamine amidotransferase of anthranilate synthase
SP_RS09020	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SP_RS09045	COG1285	pathogenesis
SP_RS09050	COG1178	ABC-type Fe3 transport system permease component
SP_RS09070	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SP_RS09075	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SP_RS09080	COG0704	Plays a role in the regulation of phosphate uptake
SP_RS09095	COG5434	Belongs to the glycosyl hydrolase 28 family
SP_RS09110	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SP_RS09115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SP_RS09120	COG1132	(ABC) transporter
SP_RS09125	COG1132	(ABC) transporter
SP_RS09150	COG0708	Exodeoxyribonuclease III
SP_RS09165	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SP_RS09170	COG2233	PERMEase
SP_RS09190	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SP_RS09195	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SP_RS09200	COG1609	Transcriptional regulator
SP_RS09205	COG1063	alcohol dehydrogenase
SP_RS09210	COG0789	Transcriptional regulator
SP_RS09215	COG1230	cation diffusion facilitator family transporter
SP_RS09225	COG3201	nicotinamide mononucleotide transporter
SP_RS09230	COG1174	glycine betaine transport
SP_RS09255	COG1363	Peptidase, m42
SP_RS09270	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SP_RS09275	COG4605	iron ion homeostasis
SP_RS09280	COG4604	ABC transporter, ATP-binding protein
SP_RS09285	COG4607	ABC-type enterochelin transport system periplasmic component
SP_RS09290	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SP_RS09295	COG1187	pseudouridine synthase activity
SP_RS09315	COG0517	IMP dehydrogenase activity
SP_RS09325	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SP_RS09345	COG0366	Alpha amylase catalytic
SP_RS09350	COG1263	PTS System
SP_RS09350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SP_RS09355	COG2188	Transcriptional regulator
SP_RS09375	COG4608	Belongs to the ABC transporter superfamily
SP_RS09380	COG0444	Belongs to the ABC transporter superfamily
SP_RS09385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SP_RS09390	COG0601	transmembrane transport
SP_RS09395	COG4166	transmembrane transport
SP_RS09405	COG0366	Alpha amylase catalytic
SP_RS09415	COG0395	ABC-type sugar transport system, permease component
SP_RS09420	COG1175	transmembrane transport
SP_RS09425	COG1653	transport
SP_RS09430	COG3345	alpha-galactosidase
SP_RS09435	COG2207	Transcriptional regulator
SP_RS09440	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SP_RS09440	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SP_RS09555	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SP_RS09560	COG2137	regulation of response to DNA damage stimulus
SP_RS09600	COG4221	oxidoreductase activity
SP_RS09605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SP_RS09610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SP_RS09650	COG1132	(ABC) transporter
SP_RS09740	COG5263	repeat protein
SP_RS09740	COG5632	N-Acetylmuramoyl-L-alanine amidase
SP_RS09755	COG1058	Belongs to the CinA family
SP_RS09755	COG1546	Belongs to the CinA family
SP_RS09760	COG1316	TRANSCRIPTIONal
SP_RS09770	COG0802	atpase or kinase
SP_RS09835	COG1136	(ABC) transporter
SP_RS09865	COG1253	flavin adenine dinucleotide binding
SP_RS09880	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SP_RS09890	COG3480	Lon protease (S16) C-terminal proteolytic domain
SP_RS09900	COG0742	ribosomal rna small subunit methyltransferase
SP_RS09920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SP_RS09925	COG1254	Belongs to the acylphosphatase family
SP_RS09935	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SP_RS09945	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SP_RS09960	COG1564	THIamine pyrophosphokinase
SP_RS09970	COG1162	GTPase activity
SP_RS10000	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SP_RS10005	COG0084	hydrolase, TatD family'
SP_RS10020	COG0436	Aminotransferase
SP_RS10030	COG0589	response to stress
SP_RS10035	COG0561	phosphatase activity
SP_RS10040	COG0252	asparaginase activity
SP_RS10050	COG1609	Transcriptional regulator
SP_RS10055	COG2197	response regulator
SP_RS10060	COG4585	Histidine kinase
SP_RS10065	COG0842	Transport permease protein
SP_RS10070	COG1131	(ABC) transporter
SP_RS10170	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SP_RS10175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SP_RS10180	COG0564	pseudouridine synthase activity
SP_RS10190	COG0577	efflux transmembrane transporter activity
SP_RS10205	COG0157	Belongs to the NadC ModD family
SP_RS10215	COG4133	protoheme IX ABC transporter activity
SP_RS10220	COG2188	Transcriptional regulator
SP_RS10225	COG2723	6-phospho-beta-galactosidase activity
SP_RS10230	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SP_RS10240	COG1447	Phosphotransferase system cellobiose-specific component IIA
SP_RS10245	COG1012	belongs to the aldehyde dehydrogenase family
SP_RS10245	COG1454	alcohol dehydrogenase
SP_RS10255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SP_RS10265	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SP_RS10285	COG3623	hexulose-6-phosphate isomerase
SP_RS10295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SP_RS10305	COG3037	sugar-specific permease SgaT UlaA
SP_RS10315	COG1847	R3H domain protein
SP_RS10320	COG0706	membrane insertase activity
SP_RS10325	COG0594	ribonuclease P activity
SP_RS10330	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SP_RS10370	COG4537	Required for transformation and DNA binding
SP_RS10375	COG1459	type II secretion system
SP_RS10380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SP_RS10390	COG1063	alcohol dehydrogenase
SP_RS10415	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SP_RS10420	COG3759	membrane
SP_RS10435	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SP_RS10435	COG0131	Imidazoleglycerol-phosphate dehydratase
SP_RS10440	COG0534	Mate efflux family protein
SP_RS10540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SP_RS10545	COG0166	Belongs to the GPI family
SP_RS10555	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SP_RS10560	COG1132	(ABC) transporter
SP_RS10570	COG1132	(ABC) transporter
SP_RS10580	COG1438	arginine binding
SP_RS10585	COG0018	arginyl-trna synthetase
SP_RS10600	COG0745	RESPONSE REGULATOR receiver
SP_RS10605	COG5002	protein histidine kinase activity
SP_RS10610	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SP_RS10615	COG0573	inorganic phosphate transmembrane transporter activity
SP_RS10625	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SP_RS10630	COG0704	Plays a role in the regulation of phosphate uptake
SP_RS10650	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SP_RS10670	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SP_RS10675	COG1473	amidohydrolase
SP_RS10685	COG0697	spore germination
SP_RS10690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SP_RS10690	COG4499	WXG100 protein secretion system (Wss), protein YukC
SP_RS10700	COG2217	Heavy metal translocating P-type atpase
SP_RS10710	COG2226	methyltransferase
SP_RS10735	COG0058	SHG alpha-glucan phosphorylase activity
SP_RS10740	COG1640	4-alpha-glucanotransferase
SP_RS10745	COG2182	Extracellular solute-binding protein
SP_RS10750	COG1175	transmembrane transport
SP_RS10755	COG3833	ABC-type maltose transport systems, permease component
SP_RS10760	COG5521	maltodextrose utilization protein MalA
SP_RS10765	COG1609	Transcriptional regulator
SP_RS10775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SP_RS10780	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SP_RS10810	COG1476	TRANSCRIPTIONal
SP_RS10825	COG0124	histidyl-tRNA synthetase
SP_RS10840	COG2151	metal-sulfur cluster biosynthetic enzyme
SP_RS10855	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SP_RS10860	COG3959	Transketolase, thiamine diphosphate binding domain
SP_RS10875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SP_RS10895	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SP_RS10935	COG0383	alpha-mannosidase activity
SP_RS10945	COG3537	Alpha-1,2-mannosidase
SP_RS10965	COG0549	Belongs to the carbamate kinase family
SP_RS10970	COG1288	antiporter activity
SP_RS10975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SP_RS10990	COG3583	domain protein
SP_RS10990	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SP_RS10990	COG3064	Membrane
SP_RS11005	COG1454	alcohol dehydrogenase
SP_RS11010	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
SP_RS11025	COG3716	PTS system mannose fructose sorbose family IID component
SP_RS11035	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SP_RS11055	COG1070	Carbohydrate kinase
SP_RS11065	COG3443	Belongs to the bacterial solute-binding protein 9 family
SP_RS11065	COG0803	Belongs to the bacterial solute-binding protein 9 family
SP_RS11070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SP_RS11075	COG1121	(ABC) transporter
SP_RS11080	COG1846	Transcriptional regulator
SP_RS11085	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SP_RS11095	COG1696	Membrane protein involved in D-alanine export
SP_RS11120	COG2211	Major facilitator Superfamily
SP_RS11130	COG3344	reverse transcriptase
SP_RS11155	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SP_RS11160	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SP_RS11180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SP_RS11190	COG1755	Isoprenylcysteine carboxyl methyltransferase
SP_RS11195	COG5002	protein histidine kinase activity
SP_RS11200	COG0745	RESPONSE REGULATOR receiver
SP_RS11210	COG0542	response to heat
SP_RS11215	COG4463	regulation of RNA biosynthetic process
SP_RS11220	COG1116	anion transmembrane transporter activity
SP_RS11225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SP_RS11230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SP_RS11250	COG0305	Participates in initiation and elongation during chromosome replication
SP_RS11270	COG1040	competence protein
SP_RS11275	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SP_RS11280	COG1739	Uncharacterized protein family UPF0029
SP_RS11295	COG3335	DDE superfamily endonuclease
SP_RS11310	COG0052	Belongs to the universal ribosomal protein uS2 family
SP_RS11315	COG3942	CHAP domain
SP_RS11325	COG1792	Involved in formation and maintenance of cell shape
SP_RS11330	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SP_RS11335	COG1122	ATPase activity
SP_RS11340	COG1122	ATPase activity
SP_RS11345	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SP_RS11355	COG0612	Peptidase, M16
SP_RS11360	COG0612	Peptidase, M16
SP_RS11365	COG2501	S4 domain
SP_RS11375	COG0516	GMP reductase activity
SP_RS11375	COG0517	IMP dehydrogenase activity
SP_RS11380	COG0180	Tryptophanyl-tRNA synthetase
SP_RS11385	COG0488	(ABC) transporter
SP_RS11395	COG1511	domain protein
SP_RS11405	COG1511	domain protein
SP_RS11450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SP_RS11455	COG1475	DNA binding