locus-tag	class	description
ES276_RS00010	COG0592	DNA-directed DNA polymerase activity
ES276_RS00020	COG0012	GTP binding
ES276_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ES276_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ES276_RS00050	COG0037	tRNA processing
ES276_RS00055	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ES276_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ES276_RS00135	COG0756	dUTP diphosphatase activity
ES276_RS00145	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ES276_RS00160	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ES276_RS00180	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES276_RS00180	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES276_RS00185	COG1832	CoA-binding protein
ES276_RS00190	COG2855	membrane
ES276_RS00195	COG0436	Aminotransferase
ES276_RS00210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES276_RS00225	COG2274	protein secretion by the type I secretion system
ES276_RS00230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ES276_RS00240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ES276_RS00245	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ES276_RS00250	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ES276_RS00255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ES276_RS00265	COG0138	bifunctional purine biosynthesis protein purh
ES276_RS00270	COG0151	Belongs to the GarS family
ES276_RS00280	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ES276_RS00295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ES276_RS00300	COG3064	Membrane
ES276_RS00300	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ES276_RS00300	COG3583	domain protein
ES276_RS00315	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES276_RS00320	COG3715	PTS system
ES276_RS00325	COG3716	PTS system mannose fructose sorbose family IID component
ES276_RS00335	COG2222	sugar isomerase
ES276_RS00345	COG2514	catechol 2,3-dioxygenase activity
ES276_RS00350	COG1937	Protein conserved in bacteria
ES276_RS00380	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ES276_RS00385	COG0569	domain protein
ES276_RS00390	COG1215	transferase activity, transferring glycosyl groups
ES276_RS00410	COG5002	protein histidine kinase activity
ES276_RS00440	COG4209	transmembrane transport
ES276_RS00445	COG0395	ABC-type sugar transport system, permease component
ES276_RS00450	COG1653	transport
ES276_RS00480	COG1695	Transcriptional regulator
ES276_RS00505	COG0546	phosphoglycolate phosphatase activity
ES276_RS00510	COG1760	l-serine dehydratase
ES276_RS00515	COG1760	l-serine dehydratase
ES276_RS00545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES276_RS00645	COG0494	nUDIX hydrolase
ES276_RS00650	COG0445	tRNA wobble uridine modification
ES276_RS00685	COG1214	PFAM Peptidase M22, glycoprotease
ES276_RS00695	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ES276_RS00715	COG0438	transferase activity, transferring glycosyl groups
ES276_RS00745	COG1396	sequence-specific DNA binding
ES276_RS00785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES276_RS00790	COG1464	Belongs to the NlpA lipoprotein family
ES276_RS00795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES276_RS00800	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ES276_RS00820	COG2972	Histidine kinase
ES276_RS00825	COG4753	response regulator
ES276_RS00825	COG2207	Transcriptional regulator
ES276_RS00835	COG1780	Probably involved in ribonucleotide reductase function
ES276_RS00865	COG0019	diaminopimelate decarboxylase activity
ES276_RS00900	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ES276_RS00900	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ES276_RS00920	COG2818	Glycosylase
ES276_RS00945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ES276_RS00950	COG0006	proline dipeptidase activity
ES276_RS00955	COG1393	Belongs to the ArsC family
ES276_RS00980	COG0285	dihydrofolate synthase activity
ES276_RS00990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES276_RS01005	COG1328	CTP reductase activity
ES276_RS01055	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ES276_RS01080	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ES276_RS01110	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ES276_RS01120	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ES276_RS01135	COG0201	protein transport
ES276_RS01145	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ES276_RS01150	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ES276_RS01160	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ES276_RS01165	COG0202	RNA polymerase activity
ES276_RS01170	COG0203	ribosomal protein L17
ES276_RS01175	COG3830	Belongs to the UPF0237 family
ES276_RS01180	COG2848	UPF0210 protein
ES276_RS01195	COG3842	ATPase activity
ES276_RS01205	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ES276_RS01210	COG1349	DNA-binding transcription factor activity
ES276_RS01220	COG1447	Phosphotransferase system cellobiose-specific component IIA
ES276_RS01225	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES276_RS01230	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES276_RS01235	COG1882	Formate acetyltransferase
ES276_RS01250	COG0495	leucyl-tRNA aminoacylation
ES276_RS01275	COG2255	four-way junction helicase activity
ES276_RS01285	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ES276_RS01290	COG4589	Belongs to the CDS family
ES276_RS01295	COG0750	zinc metalloprotease
ES276_RS01300	COG0442	prolyl-tRNA aminoacylation
ES276_RS01305	COG2723	6-phospho-beta-galactosidase activity
ES276_RS01310	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ES276_RS01320	COG1523	belongs to the glycosyl hydrolase 13 family
ES276_RS01360	COG2309	aminopeptidase activity
ES276_RS01365	COG2261	transglycosylase associated protein
ES276_RS01375	COG1187	pseudouridine synthase activity
ES276_RS01380	COG3579	cysteine-type endopeptidase activity
ES276_RS01385	COG3716	PTS system mannose fructose sorbose family IID component
ES276_RS01390	COG3715	PTS system
ES276_RS01400	COG1064	alcohol dehydrogenase
ES276_RS01405	COG0561	phosphatase activity
ES276_RS01410	COG2252	PERMEase
ES276_RS01420	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ES276_RS01425	COG0285	dihydrofolate synthase activity
ES276_RS01435	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ES276_RS01435	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ES276_RS01450	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ES276_RS01465	COG1373	ATPase (AAA superfamily
ES276_RS01475	COG0577	efflux transmembrane transporter activity
ES276_RS01485	COG0564	pseudouridine synthase activity
ES276_RS01495	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ES276_RS01595	COG1131	(ABC) transporter
ES276_RS01600	COG0842	Transport permease protein
ES276_RS01605	COG4585	Histidine kinase
ES276_RS01610	COG2197	response regulator
ES276_RS01615	COG1609	Transcriptional regulator
ES276_RS01625	COG0252	asparaginase activity
ES276_RS01630	COG0561	phosphatase activity
ES276_RS01635	COG0589	response to stress
ES276_RS01645	COG0436	Aminotransferase
ES276_RS01660	COG0084	hydrolase, TatD family'
ES276_RS01665	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ES276_RS01695	COG1162	GTPase activity
ES276_RS01705	COG1564	THIamine pyrophosphokinase
ES276_RS01720	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ES276_RS01730	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ES276_RS01740	COG1254	Belongs to the acylphosphatase family
ES276_RS01745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ES276_RS01760	COG0742	ribosomal rna small subunit methyltransferase
ES276_RS01770	COG3480	Lon protease (S16) C-terminal proteolytic domain
ES276_RS01780	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ES276_RS01795	COG1253	flavin adenine dinucleotide binding
ES276_RS01825	COG1136	(ABC) transporter
ES276_RS01825	COG0577	efflux transmembrane transporter activity
ES276_RS01845	COG0802	atpase or kinase
ES276_RS01855	COG1316	TRANSCRIPTIONal
ES276_RS01875	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES276_RS01875	COG5263	repeat protein
ES276_RS01965	COG1132	(ABC) transporter
ES276_RS02005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES276_RS02010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES276_RS02015	COG4221	oxidoreductase activity
ES276_RS02050	COG2137	regulation of response to DNA damage stimulus
ES276_RS02055	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ES276_RS02170	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ES276_RS02170	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ES276_RS02175	COG2207	Transcriptional regulator
ES276_RS02180	COG3345	alpha-galactosidase
ES276_RS02185	COG1653	transport
ES276_RS02190	COG1175	transmembrane transport
ES276_RS02195	COG0395	ABC-type sugar transport system, permease component
ES276_RS02205	COG0366	Alpha amylase catalytic
ES276_RS02215	COG4166	transmembrane transport
ES276_RS02220	COG0601	transmembrane transport
ES276_RS02225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES276_RS02230	COG0444	Belongs to the ABC transporter superfamily
ES276_RS02235	COG4608	Belongs to the ABC transporter superfamily
ES276_RS02245	COG2188	Transcriptional regulator
ES276_RS02250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES276_RS02250	COG1263	PTS System
ES276_RS02255	COG0366	Alpha amylase catalytic
ES276_RS02270	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ES276_RS02280	COG0517	IMP dehydrogenase activity
ES276_RS02300	COG1187	pseudouridine synthase activity
ES276_RS02305	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ES276_RS02310	COG4607	ABC-type enterochelin transport system periplasmic component
ES276_RS02315	COG4604	ABC transporter, ATP-binding protein
ES276_RS02320	COG4605	iron ion homeostasis
ES276_RS02325	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES276_RS02335	COG1363	Peptidase, m42
ES276_RS02365	COG1174	glycine betaine transport
ES276_RS02370	COG3201	nicotinamide mononucleotide transporter
ES276_RS02380	COG1230	cation diffusion facilitator family transporter
ES276_RS02385	COG0789	Transcriptional regulator
ES276_RS02390	COG1063	alcohol dehydrogenase
ES276_RS02395	COG1609	Transcriptional regulator
ES276_RS02400	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ES276_RS02405	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ES276_RS02425	COG2233	PERMEase
ES276_RS02430	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ES276_RS02445	COG0708	Exodeoxyribonuclease III
ES276_RS02460	COG1132	(ABC) transporter
ES276_RS02465	COG1132	(ABC) transporter
ES276_RS02470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ES276_RS02475	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES276_RS02480	COG5434	Belongs to the glycosyl hydrolase 28 family
ES276_RS02495	COG0704	Plays a role in the regulation of phosphate uptake
ES276_RS02500	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ES276_RS02505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ES276_RS02525	COG1178	ABC-type Fe3 transport system permease component
ES276_RS02530	COG1285	pathogenesis
ES276_RS02550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ES276_RS02555	COG0512	Glutamine amidotransferase of anthranilate synthase
ES276_RS02585	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ES276_RS02600	COG3237	CsbD-like
ES276_RS02620	COG2261	transglycosylase associated protein
ES276_RS02625	COG3711	transcriptional antiterminator
ES276_RS02635	COG4209	transmembrane transport
ES276_RS02640	COG0395	ABC-type sugar transport system, permease component
ES276_RS02645	COG1653	transport
ES276_RS02650	COG1621	beta-fructofuranosidase activity
ES276_RS02675	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ES276_RS02710	COG1051	belongs to the nudix hydrolase family
ES276_RS02715	COG2264	protein methyltransferase activity
ES276_RS02720	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ES276_RS02725	COG1164	Oligoendopeptidase f
ES276_RS02735	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ES276_RS02745	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ES276_RS02750	COG3118	belongs to the thioredoxin family
ES276_RS02785	COG1442	glycosyl transferase family 8
ES276_RS02785	COG1216	Glycosyl transferase, family 2
ES276_RS02790	COG1442	glycosyl transferase family 8
ES276_RS02795	COG1442	glycosyl transferase family 8
ES276_RS02795	COG1216	Glycosyl transferase, family 2
ES276_RS02805	COG1442	glycosyl transferase family 8
ES276_RS02810	COG1442	glycosyl transferase family 8
ES276_RS02815	COG1442	glycosyl transferase family 8
ES276_RS02820	COG1215	transferase activity, transferring glycosyl groups
ES276_RS02825	COG0201	protein transport
ES276_RS02845	COG0653	protein targeting
ES276_RS02850	COG0438	transferase activity, transferring glycosyl groups
ES276_RS02855	COG0438	transferase activity, transferring glycosyl groups
ES276_RS02880	COG0668	transmembrane transport
ES276_RS02895	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ES276_RS02900	COG1534	Rna-binding protein
ES276_RS02905	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ES276_RS02910	COG1713	HD superfamily hydrolase involved in NAD metabolism
ES276_RS02920	COG0799	negative regulation of ribosome biogenesis
ES276_RS02925	COG2226	methyltransferase
ES276_RS02930	COG1323	Belongs to the UPF0348 family
ES276_RS02940	COG4115	mRNA cleavage
ES276_RS02950	COG0194	GDP metabolic process
ES276_RS02960	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ES276_RS02970	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ES276_RS02970	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ES276_RS02975	COG0631	protein serine/threonine phosphatase activity
ES276_RS02980	COG2815	serine threonine protein kinase
ES276_RS02980	COG0515	serine threonine protein kinase
ES276_RS03005	COG3425	synthase
ES276_RS03020	COG1609	Transcriptional regulator
ES276_RS03025	COG1621	beta-fructofuranosidase activity
ES276_RS03030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES276_RS03030	COG1263	PTS System
ES276_RS03030	COG2190	(PTS) system
ES276_RS03035	COG1940	carbohydrate kinase activity
ES276_RS03055	COG4152	abc transporter atp-binding protein
ES276_RS03060	COG1668	transmembrane transport
ES276_RS03070	COG1131	(ABC) transporter
ES276_RS03075	COG1725	Transcriptional regulator
ES276_RS03090	COG1484	DNA-dependent DNA replication
ES276_RS03095	COG0778	Nitroreductase
ES276_RS03125	COG1131	(ABC) transporter
ES276_RS03135	COG0653	protein targeting
ES276_RS03140	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ES276_RS03145	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ES276_RS03160	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ES276_RS03170	COG3458	cephalosporin-C deacetylase activity
ES276_RS03195	COG1653	transport
ES276_RS03200	COG1175	transmembrane transport
ES276_RS03210	COG4409	exo-alpha-(2->6)-sialidase activity
ES276_RS03215	COG0673	inositol 2-dehydrogenase activity
ES276_RS03225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES276_RS03225	COG2190	(PTS) system
ES276_RS03225	COG1263	PTS System
ES276_RS03235	COG1175	transmembrane transport
ES276_RS03240	COG0395	ABC-type sugar transport system, permease component
ES276_RS03245	COG2731	YhcH YjgK YiaL family protein
ES276_RS03265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ES276_RS03280	COG0768	penicillin binding
ES276_RS03295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ES276_RS03300	COG1051	belongs to the nudix hydrolase family
ES276_RS03320	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ES276_RS03340	COG3599	regulation of cell shape
ES276_RS03365	COG1136	(ABC) transporter
ES276_RS03365	COG0577	efflux transmembrane transporter activity
ES276_RS03375	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ES276_RS03380	COG0803	Belongs to the bacterial solute-binding protein 9 family
ES276_RS03395	COG3590	peptidase
ES276_RS03440	COG1959	2 iron, 2 sulfur cluster binding
ES276_RS03455	COG0745	RESPONSE REGULATOR receiver
ES276_RS03460	COG5002	protein histidine kinase activity
ES276_RS03475	COG2910	NAD(P)H-binding
ES276_RS03490	COG0204	Acyl-transferase
ES276_RS03495	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ES276_RS03515	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES276_RS03520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES276_RS03520	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES276_RS03520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES276_RS03525	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ES276_RS03550	COG2384	SAM-dependent methyltransferase
ES276_RS03555	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ES276_RS03560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ES276_RS03570	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ES276_RS03575	COG0463	Glycosyl transferase, family 2
ES276_RS03595	COG2824	Alkylphosphonate utilization operon protein PhnA
ES276_RS03615	COG0351	phosphomethylpyrimidine kinase
ES276_RS03645	COG0006	proline dipeptidase activity
ES276_RS03650	COG3442	glutamine amidotransferase
ES276_RS03655	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ES276_RS03660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES276_RS03665	COG2223	nitrite transmembrane transporter activity
ES276_RS03670	COG0513	Belongs to the DEAD box helicase family
ES276_RS03675	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ES276_RS03680	COG1335	isochorismatase
ES276_RS03695	COG3842	ATPase activity
ES276_RS03705	COG2226	methyltransferase
ES276_RS03720	COG3935	DnaD domain protein
ES276_RS03730	COG4193	domain, Protein
ES276_RS03730	COG5263	repeat protein
ES276_RS03740	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ES276_RS03755	COG0251	oxidation-reduction process
ES276_RS03765	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ES276_RS03770	COG1481	regulation of sporulation
ES276_RS03780	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ES276_RS03800	COG1307	EDD domain protein, DegV family
ES276_RS03810	COG0617	tRNA 3'-terminal CCA addition
ES276_RS03815	COG0488	(ABC) transporter
ES276_RS03820	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES276_RS03830	COG0625	glutathione transferase activity
ES276_RS03835	COG0242	peptide deformylase activity
ES276_RS03850	COG3022	response to hydroperoxide
ES276_RS03865	COG0436	Aminotransferase
ES276_RS03875	COG0017	Asparaginyl-tRNA synthetase
ES276_RS03885	COG0629	single-stranded DNA binding
ES276_RS03890	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ES276_RS03900	COG1098	S1 RNA binding domain
ES276_RS03905	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ES276_RS03910	COG2827	Endonuclease containing a URI domain
ES276_RS03935	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ES276_RS03940	COG2244	polysaccharide biosynthetic process
ES276_RS03945	COG4166	transmembrane transport
ES276_RS03955	COG1132	(ABC) transporter
ES276_RS03960	COG0626	cystathionine gamma-synthase activity
ES276_RS03965	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ES276_RS03970	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ES276_RS03995	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ES276_RS04000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ES276_RS04040	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ES276_RS04055	COG2706	6-phosphogluconolactonase activity
ES276_RS04060	COG0628	permease
ES276_RS04080	COG1126	abc transporter atp-binding protein
ES276_RS04085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES276_RS04095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ES276_RS04140	COG1126	abc transporter atp-binding protein
ES276_RS04145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES276_RS04155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ES276_RS04180	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ES276_RS04225	COG0726	polysaccharide deacetylase
ES276_RS04230	COG0656	L-ascorbic acid biosynthetic process
ES276_RS04240	COG0752	glycyl-tRNA synthetase alpha subunit
ES276_RS04255	COG1053	succinate dehydrogenase
ES276_RS04255	COG3976	FMN-binding domain protein
ES276_RS04255	COG0431	NADPH-dependent FMN reductase
ES276_RS04285	COG1272	protein, Hemolysin III
ES276_RS04300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ES276_RS04305	COG1393	Belongs to the ArsC family
ES276_RS04315	COG1126	abc transporter atp-binding protein
ES276_RS04325	COG0492	ferredoxin-NADP+ reductase activity
ES276_RS04350	COG0561	phosphatase activity
ES276_RS04365	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ES276_RS04370	COG0697	spore germination
ES276_RS04375	COG2188	Transcriptional regulator
ES276_RS04425	COG1132	(ABC) transporter
ES276_RS04440	COG1283	sodium-dependent phosphate transmembrane transporter activity
ES276_RS04450	COG0126	phosphoglycerate kinase activity
ES276_RS04460	COG0789	Transcriptional regulator
ES276_RS04465	COG0174	glutamine synthetase
ES276_RS04480	COG0732	type I restriction modification DNA specificity domain
ES276_RS04490	COG4974	Belongs to the 'phage' integrase family
ES276_RS04525	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ES276_RS04535	COG0484	heat shock protein binding
ES276_RS04545	COG0537	adenosine 5'-monophosphoramidase activity
ES276_RS04550	COG1131	(ABC) transporter
ES276_RS04575	COG3290	protein histidine kinase activity
ES276_RS04585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ES276_RS04665	COG1266	CAAX protease self-immunity
ES276_RS04685	COG0195	Participates in both transcription termination and antitermination
ES276_RS04690	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ES276_RS04700	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ES276_RS04700	COG3064	Membrane
ES276_RS04705	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ES276_RS04750	COG0519	Catalyzes the synthesis of GMP from XMP
ES276_RS04760	COG0525	valine-tRNA ligase activity
ES276_RS04815	COG0456	acetyltransferase
ES276_RS04820	COG0072	phenylalanine-tRNA ligase activity
ES276_RS04820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES276_RS04835	COG3620	sequence-specific DNA binding
ES276_RS04840	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ES276_RS04850	COG1185	polyribonucleotide nucleotidyltransferase activity
ES276_RS04855	COG1045	serine acetyltransferase
ES276_RS04865	COG0215	cysteine-tRNA ligase activity
ES276_RS04870	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ES276_RS04895	COG0577	efflux transmembrane transporter activity
ES276_RS04900	COG1136	(ABC) transporter
ES276_RS04905	COG0577	efflux transmembrane transporter activity
ES276_RS04915	COG0745	RESPONSE REGULATOR receiver
ES276_RS04920	COG5002	protein histidine kinase activity
ES276_RS04925	COG0191	fructose-bisphosphate aldolase activity
ES276_RS04930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ES276_RS04935	COG0765	amino acid transport
ES276_RS04940	COG0765	amino acid transport
ES276_RS04945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES276_RS04985	COG0322	excinuclease ABC activity
ES276_RS04995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES276_RS05010	COG1573	uracil-dna glycosylase
ES276_RS05020	COG1114	Component of the transport system for branched-chain amino acids
ES276_RS05025	COG1363	Peptidase, m42
ES276_RS05065	COG4555	ABC transporter
ES276_RS05095	COG1404	Belongs to the peptidase S8 family
ES276_RS05115	COG3775	system Galactitol-specific IIC component
ES276_RS05125	COG3250	beta-galactosidase activity
ES276_RS05145	COG1242	4 iron, 4 sulfur cluster binding
ES276_RS05150	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ES276_RS05170	COG0785	Cytochrome C biogenesis protein
ES276_RS05175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES276_RS05180	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ES276_RS05180	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ES276_RS05185	COG2207	Transcriptional regulator
ES276_RS05185	COG4753	response regulator
ES276_RS05190	COG2972	Histidine kinase
ES276_RS05195	COG4475	Protein of unknown function (DUF436)
ES276_RS05200	COG3064	Membrane
ES276_RS05205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ES276_RS05220	COG1940	carbohydrate kinase activity
ES276_RS05240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ES276_RS05245	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ES276_RS05255	COG0300	oxidoreductase activity
ES276_RS05270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ES276_RS05280	COG1187	pseudouridine synthase activity
ES276_RS05285	COG1217	gtp-binding protein TYPA
ES276_RS05305	COG1136	(ABC) transporter
ES276_RS05310	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ES276_RS05315	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ES276_RS05320	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ES276_RS05355	COG0284	orotidine-5'-phosphate decarboxylase activity
ES276_RS05360	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ES276_RS05380	COG1131	(ABC) transporter
ES276_RS05385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES276_RS05395	COG1126	abc transporter atp-binding protein
ES276_RS05400	COG0765	amino acid transport
ES276_RS05405	COG0765	amino acid transport
ES276_RS05415	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ES276_RS05420	COG1304	FMN binding
ES276_RS05430	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ES276_RS05435	COG0352	thiamine-phosphate diphosphorylase activity
ES276_RS05445	COG4172	Belongs to the ABC transporter superfamily
ES276_RS05455	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ES276_RS05465	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ES276_RS05470	COG0352	thiamine-phosphate diphosphorylase activity
ES276_RS05495	COG0028	Belongs to the TPP enzyme family
ES276_RS05515	COG1482	cell wall glycoprotein biosynthetic process
ES276_RS05525	COG0789	Transcriptional regulator
ES276_RS05535	COG2081	HI0933 family
ES276_RS05540	COG1307	EDD domain protein, DegV family
ES276_RS05550	COG2131	deaminase
ES276_RS05555	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ES276_RS05595	COG0517	IMP dehydrogenase activity
ES276_RS05595	COG0617	tRNA 3'-terminal CCA addition
ES276_RS05595	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ES276_RS05605	COG2884	Cell division ATP-binding protein ftsE
ES276_RS05610	COG2177	Part of the ABC transporter FtsEX involved in
ES276_RS05615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES276_RS05615	COG2190	(PTS) system
ES276_RS05615	COG1263	PTS System
ES276_RS05625	COG0513	Belongs to the DEAD box helicase family
ES276_RS05635	COG0167	dihydroorotate dehydrogenase activity
ES276_RS05645	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ES276_RS05650	COG4470	Protein conserved in bacteria
ES276_RS05655	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ES276_RS05665	COG0488	(ABC) transporter
ES276_RS05690	COG1837	Belongs to the UPF0109 family
ES276_RS05705	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ES276_RS05715	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ES276_RS05715	COG1328	CTP reductase activity
ES276_RS05725	COG4443	Transcriptional Coactivator p15 (PC4)
ES276_RS05735	COG1268	BioY protein
ES276_RS05740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES276_RS05745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ES276_RS05750	COG1136	(ABC) transporter
ES276_RS05755	COG0577	efflux transmembrane transporter activity
ES276_RS05760	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES276_RS05760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES276_RS05780	COG4989	oxidoreductase activity
ES276_RS05790	COG1028	Short-chain dehydrogenase reductase Sdr
ES276_RS05815	COG0745	RESPONSE REGULATOR receiver
ES276_RS05820	COG5002	protein histidine kinase activity
ES276_RS05840	COG0772	Belongs to the SEDS family
ES276_RS05845	COG0693	protein deglycase activity
ES276_RS05855	COG0187	DNA topoisomerase II activity
ES276_RS05860	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ES276_RS05895	COG0542	response to heat
ES276_RS05900	COG4703	Protein of unknown function (DUF1797)
ES276_RS05905	COG0765	amino acid transport
ES276_RS05910	COG1126	abc transporter atp-binding protein
ES276_RS05915	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ES276_RS05920	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ES276_RS05940	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ES276_RS05985	COG2813	Specifically methylates the guanine in position
ES276_RS05990	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ES276_RS06000	COG0295	cytidine deaminase activity
ES276_RS06005	COG1744	ABC transporter substrate-binding protein PnrA-like
ES276_RS06010	COG3845	ABC transporter
ES276_RS06015	COG4603	Belongs to the binding-protein-dependent transport system permease family
ES276_RS06020	COG1079	Belongs to the binding-protein-dependent transport system permease family
ES276_RS06035	COG0187	DNA topoisomerase II activity
ES276_RS06040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ES276_RS06045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES276_RS06050	COG4166	transmembrane transport
ES276_RS06085	COG0539	negative regulation of cytoplasmic translation
ES276_RS06095	COG1956	GAF domain-containing protein
ES276_RS06100	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ES276_RS06115	COG0719	Fe-S assembly protein
ES276_RS06120	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ES276_RS06130	COG0719	Fe-S assembly protein
ES276_RS06135	COG1686	Belongs to the peptidase S11 family
ES276_RS06140	COG0628	permease
ES276_RS06155	COG1349	DNA-binding transcription factor activity
ES276_RS06160	COG1105	Belongs to the carbohydrate kinase PfkB family
ES276_RS06165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES276_RS06165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES276_RS06165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES276_RS06170	COG0697	spore germination
ES276_RS06170	COG1674	ftsk spoiiie
ES276_RS06180	COG1104	cysteine desulfurase activity
ES276_RS06240	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
ES276_RS06245	COG1438	arginine binding
ES276_RS06265	COG0469	pyruvate kinase activity
ES276_RS06270	COG0582	viral genome integration into host DNA
ES276_RS06300	COG3689	TIGRFAM TIGR03943 family protein
ES276_RS06305	COG0701	Predicted permease
ES276_RS06310	COG3955	Domain of unknown function (DUF1919)
ES276_RS06315	COG2183	response to ionizing radiation
ES276_RS06335	COG1136	(ABC) transporter
ES276_RS06340	COG0577	efflux transmembrane transporter activity
ES276_RS06355	COG1982	Orn Lys Arg decarboxylase major
ES276_RS06370	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ES276_RS06390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ES276_RS06395	COG0561	phosphatase activity
ES276_RS06415	COG0583	DNA-binding transcription factor activity
ES276_RS06420	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ES276_RS06425	COG0564	pseudouridine synthase activity
ES276_RS06430	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ES276_RS06435	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ES276_RS06445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES276_RS06455	COG0470	DNA polymerase III
ES276_RS06500	COG0528	UMP kinase activity
ES276_RS06510	COG2996	Protein conserved in bacteria
ES276_RS06520	COG1702	phosphate starvation-inducible protein PhoH
ES276_RS06540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES276_RS06545	COG1555	photosystem II stabilization
ES276_RS06545	COG1596	polysaccharide export
ES276_RS06550	COG0658	competence protein
ES276_RS06550	COG2333	competence protein COMEC
ES276_RS06555	COG1131	(ABC) transporter
ES276_RS06590	COG0543	2 iron, 2 sulfur cluster binding
ES276_RS06595	COG0167	dihydroorotate dehydrogenase activity
ES276_RS06600	COG4193	domain, Protein
ES276_RS06600	COG5263	repeat protein
ES276_RS06605	COG1293	RNA-binding protein homologous to eukaryotic snRNP
ES276_RS06615	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ES276_RS06625	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ES276_RS06630	COG0237	dephospho-CoA kinase activity
ES276_RS06635	COG2814	Major facilitator Superfamily
ES276_RS06650	COG0557	exoribonuclease II activity
ES276_RS06660	COG0500	methyltransferase
ES276_RS06660	COG3615	Tellurite resistance protein tehB
ES276_RS06675	COG4122	O-methyltransferase activity
ES276_RS06700	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ES276_RS06715	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ES276_RS06720	COG0494	nUDIX hydrolase
ES276_RS06730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ES276_RS06740	COG2176	DNA-directed DNA polymerase activity
ES276_RS06745	COG0584	glycerophosphoryl diester phosphodiesterase
ES276_RS06765	COG0785	Cytochrome C biogenesis protein
ES276_RS06770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES276_RS06775	COG0531	amino acid
ES276_RS06780	COG3443	Belongs to the bacterial solute-binding protein 9 family
ES276_RS06780	COG0803	Belongs to the bacterial solute-binding protein 9 family
ES276_RS06790	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ES276_RS06795	COG1011	Hydrolase
ES276_RS06810	COG1051	belongs to the nudix hydrolase family
ES276_RS06815	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ES276_RS06825	COG0534	Mate efflux family protein
ES276_RS06830	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES276_RS06835	COG0022	dehydrogenase e1 component
ES276_RS06840	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES276_RS06845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES276_RS06850	COG0095	Lipoate-protein ligase
ES276_RS06855	COG4974	Belongs to the 'phage' integrase family
ES276_RS06865	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ES276_RS06870	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ES276_RS06875	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ES276_RS06875	COG3583	domain protein
ES276_RS06885	COG1074	ATP-dependent DNA helicase activity
ES276_RS06890	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ES276_RS06905	COG0582	viral genome integration into host DNA
ES276_RS06925	COG0560	Phosphoserine phosphatase
ES276_RS06930	COG0560	Phosphoserine phosphatase
ES276_RS06940	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ES276_RS06950	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ES276_RS06955	COG1012	belongs to the aldehyde dehydrogenase family
ES276_RS06960	COG1523	belongs to the glycosyl hydrolase 13 family
ES276_RS06980	COG0488	(ABC) transporter
ES276_RS06990	COG1307	EDD domain protein, DegV family
ES276_RS06995	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES276_RS07000	COG0196	riboflavin kinase activity
ES276_RS07040	COG0280	phosphate acetyltransferase
ES276_RS07045	COG0564	pseudouridine synthase activity
ES276_RS07055	COG2357	RelA SpoT domain protein
ES276_RS07065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ES276_RS07070	COG1104	cysteine desulfurase activity
ES276_RS07090	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ES276_RS07100	COG0210	DNA helicase
ES276_RS07110	COG0024	Methionine aminopeptidase
ES276_RS07115	COG4109	DRTGG domain
ES276_RS07125	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ES276_RS07150	COG0438	transferase activity, transferring glycosyl groups
ES276_RS07155	COG0438	transferase activity, transferring glycosyl groups
ES276_RS07160	COG2151	metal-sulfur cluster biosynthetic enzyme
ES276_RS07165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ES276_RS07170	COG0358	DNA primase activity
ES276_RS07175	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ES276_RS07190	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ES276_RS07195	COG0772	Belongs to the SEDS family
ES276_RS07205	COG1396	sequence-specific DNA binding
ES276_RS07220	COG4555	ABC transporter
ES276_RS07225	COG1121	(ABC) transporter
ES276_RS07230	COG0515	serine threonine protein kinase
ES276_RS07250	COG3843	relaxase mobilization nuclease domain protein
ES276_RS07265	COG1196	nuclear chromosome segregation
ES276_RS07270	COG0613	PHP domain protein
ES276_RS07275	COG0542	response to heat
ES276_RS07280	COG1396	sequence-specific DNA binding
ES276_RS07295	COG1597	lipid kinase activity
ES276_RS07350	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES276_RS07355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES276_RS07380	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ES276_RS07390	COG0741	lytic transglycosylase activity
ES276_RS07400	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ES276_RS07415	COG2890	protein-(glutamine-N5) methyltransferase activity
ES276_RS07420	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ES276_RS07430	COG1435	thymidine kinase activity
ES276_RS07435	COG1942	4-Oxalocrotonate Tautomerase
ES276_RS07440	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ES276_RS07455	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ES276_RS07465	COG4708	membrane
ES276_RS07475	COG1970	mechanosensitive ion channel activity
ES276_RS07525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES276_RS07530	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ES276_RS07535	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES276_RS07540	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES276_RS07555	COG2723	6-phospho-beta-galactosidase activity
ES276_RS07570	COG3711	transcriptional antiterminator
ES276_RS07580	COG3684	Belongs to the aldolase LacD family
ES276_RS07585	COG1105	Belongs to the carbohydrate kinase PfkB family
ES276_RS07595	COG0698	ribose 5-phosphate isomerase
ES276_RS07630	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ES276_RS07635	COG0497	DNA recombination
ES276_RS07640	COG1438	arginine binding
ES276_RS07645	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ES276_RS07675	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ES276_RS07695	COG3764	Sortase (surface protein transpeptidase)
ES276_RS07700	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ES276_RS07730	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ES276_RS07735	COG5002	protein histidine kinase activity
ES276_RS07740	COG0745	RESPONSE REGULATOR receiver
ES276_RS07745	COG1194	a g-specific adenine glycosylase
ES276_RS07750	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ES276_RS07760	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ES276_RS07765	COG4684	Psort location CytoplasmicMembrane, score
ES276_RS07775	COG1827	regulation of RNA biosynthetic process
ES276_RS07780	COG2816	NAD+ diphosphatase activity
ES276_RS07805	COG0765	amino acid transport
ES276_RS07810	COG1126	abc transporter atp-binding protein
ES276_RS07815	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ES276_RS07820	COG0552	protein localization to endoplasmic reticulum
ES276_RS07825	COG0561	phosphatase activity
ES276_RS07830	COG0561	phosphatase activity
ES276_RS07835	COG1196	nuclear chromosome segregation
ES276_RS07860	COG1401	restriction endodeoxyribonuclease activity
ES276_RS07875	COG0066	3-isopropylmalate dehydratase activity
ES276_RS07885	COG0473	3-isopropylmalate dehydrogenase activity
ES276_RS07905	COG3142	Participates in the control of copper homeostasis
ES276_RS07910	COG2832	Protein of unknown function (DUF454)
ES276_RS07915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ES276_RS07930	COG0758	DNA mediated transformation
ES276_RS07935	COG4750	Nucleotidyl transferase
ES276_RS07950	COG1063	alcohol dehydrogenase
ES276_RS07955	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ES276_RS07965	COG3475	LICD family
ES276_RS07970	COG3475	LICD family
ES276_RS07980	COG0505	Belongs to the CarA family
ES276_RS07995	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ES276_RS08010	COG0488	(ABC) transporter
ES276_RS08020	COG1704	LemA family
ES276_RS08035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ES276_RS08050	COG1078	dGTPase activity
ES276_RS08080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ES276_RS08085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ES276_RS08090	COG0077	Prephenate dehydratase
ES276_RS08090	COG1605	Chorismate mutase
ES276_RS08095	COG0716	FMN binding
ES276_RS08100	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ES276_RS08120	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES276_RS08155	COG0295	cytidine deaminase activity
ES276_RS08165	COG2081	HI0933 family
ES276_RS08180	COG0395	ABC-type sugar transport system, permease component
ES276_RS08185	COG4209	transmembrane transport
ES276_RS08190	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
ES276_RS08220	COG0577	efflux transmembrane transporter activity
ES276_RS08220	COG1136	(ABC) transporter
ES276_RS08275	COG0402	S-adenosylhomocysteine deaminase activity
ES276_RS08285	COG1132	(ABC) transporter
ES276_RS08290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ES276_RS08290	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ES276_RS08310	COG4862	establishment of competence for transformation
ES276_RS08325	COG1215	transferase activity, transferring glycosyl groups
ES276_RS08335	COG3475	LICD family
ES276_RS08345	COG0077	Prephenate dehydratase
ES276_RS08350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ES276_RS08355	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ES276_RS08365	COG0287	Prephenate dehydrogenase
ES276_RS08390	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ES276_RS08400	COG1131	(ABC) transporter
ES276_RS08410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ES276_RS08440	COG3842	ATPase activity
ES276_RS08455	COG3527	Alpha-acetolactate decarboxylase
ES276_RS08460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES276_RS08465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES276_RS08470	COG0704	Plays a role in the regulation of phosphate uptake
ES276_RS08475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES276_RS08480	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES276_RS08485	COG0581	inorganic phosphate transmembrane transporter activity
ES276_RS08490	COG0573	inorganic phosphate transmembrane transporter activity
ES276_RS08495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ES276_RS08500	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
ES276_RS08500	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ES276_RS08505	COG0483	inositol monophosphate 1-phosphatase activity
ES276_RS08515	COG1393	Belongs to the ArsC family
ES276_RS08525	COG0647	UMP catabolic process
ES276_RS08535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ES276_RS08595	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ES276_RS08630	COG0826	peptidase U32
ES276_RS08660	COG0504	CTP synthase activity
ES276_RS08670	COG1247	-acetyltransferase
ES276_RS08680	COG0671	phosphoesterase, PA-phosphatase related
ES276_RS08685	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ES276_RS08700	COG1122	ATPase activity
ES276_RS08720	COG0569	domain protein
ES276_RS08725	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ES276_RS08730	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES276_RS08730	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES276_RS08735	COG2723	6-phospho-beta-galactosidase activity
ES276_RS08740	COG1447	Phosphotransferase system cellobiose-specific component IIA
ES276_RS08750	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES276_RS08755	COG1846	Transcriptional regulator
ES276_RS08755	COG1940	carbohydrate kinase activity
ES276_RS08815	COG1882	Formate acetyltransferase
ES276_RS08820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ES276_RS08845	COG0765	amino acid transport
ES276_RS08860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ES276_RS08880	COG0440	acetolactate synthase activity
ES276_RS08885	COG0028	Belongs to the TPP enzyme family
ES276_RS08890	COG1461	Dihydroxyacetone kinase
ES276_RS08900	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ES276_RS08910	COG1442	glycosyl transferase family 8
ES276_RS08915	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ES276_RS08975	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ES276_RS08980	COG0439	Biotin carboxylase
ES276_RS08985	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ES276_RS08995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ES276_RS09000	COG1028	Short-chain dehydrogenase reductase Sdr
ES276_RS09005	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ES276_RS09015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES276_RS09025	COG1846	Transcriptional regulator
ES276_RS09030	COG1024	Enoyl-CoA hydratase
ES276_RS09035	COG0527	aspartate kinase activity
ES276_RS09060	COG1115	amino acid carrier protein
ES276_RS09085	COG0681	Belongs to the peptidase S26 family
ES276_RS09090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ES276_RS09105	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES276_RS09110	COG3711	transcriptional antiterminator
ES276_RS09115	COG2213	PTS system mannitol-specific
ES276_RS09150	COG2197	response regulator
ES276_RS09155	COG4585	Histidine kinase
ES276_RS09215	COG0745	RESPONSE REGULATOR receiver
ES276_RS09220	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ES276_RS09230	COG0116	Belongs to the methyltransferase superfamily
ES276_RS09260	COG0366	Alpha amylase catalytic
ES276_RS09265	COG4166	transmembrane transport
ES276_RS09295	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ES276_RS09310	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ES276_RS09330	COG0438	transferase activity, transferring glycosyl groups
ES276_RS09345	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ES276_RS09350	COG0489	protein tyrosine kinase activity
ES276_RS09355	COG3944	biosynthesis protein
ES276_RS09360	COG4464	protein tyrosine phosphatase activity
ES276_RS09375	COG4166	transmembrane transport
ES276_RS09380	COG0366	Alpha amylase catalytic
ES276_RS09405	COG0768	penicillin binding
ES276_RS09410	COG4839	cell division protein FtsL
ES276_RS09415	COG0275	rRNA processing
ES276_RS09440	COG1609	Transcriptional regulator
ES276_RS09455	COG3716	PTS system mannose fructose sorbose family IID component
ES276_RS09460	COG3715	PTS system
ES276_RS09465	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES276_RS09470	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ES276_RS09480	COG1028	Short-chain dehydrogenase reductase Sdr
ES276_RS09510	COG5492	domain, Protein
ES276_RS09515	COG0386	Belongs to the glutathione peroxidase family
ES276_RS09560	COG2723	6-phospho-beta-galactosidase activity
ES276_RS09575	COG0157	Belongs to the NadC ModD family
ES276_RS09590	COG1129	ABC transporter
ES276_RS09595	COG2188	Transcriptional regulator
ES276_RS09600	COG2723	6-phospho-beta-galactosidase activity
ES276_RS09605	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES276_RS09615	COG1447	Phosphotransferase system cellobiose-specific component IIA
ES276_RS09620	COG1012	belongs to the aldehyde dehydrogenase family
ES276_RS09620	COG1454	alcohol dehydrogenase
ES276_RS09630	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ES276_RS09640	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ES276_RS09660	COG3623	hexulose-6-phosphate isomerase
ES276_RS09670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES276_RS09680	COG3037	sugar-specific permease SgaT UlaA
ES276_RS09690	COG1847	R3H domain protein
ES276_RS09695	COG0706	membrane insertase activity
ES276_RS09700	COG0594	ribonuclease P activity
ES276_RS09705	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ES276_RS09740	COG4537	Required for transformation and DNA binding
ES276_RS09745	COG1459	type II secretion system
ES276_RS09750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ES276_RS09760	COG1063	alcohol dehydrogenase
ES276_RS09785	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ES276_RS09790	COG3759	membrane
ES276_RS09805	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ES276_RS09805	COG0131	Imidazoleglycerol-phosphate dehydratase
ES276_RS09810	COG0534	Mate efflux family protein
ES276_RS09910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ES276_RS09925	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ES276_RS09930	COG1132	(ABC) transporter
ES276_RS09940	COG1132	(ABC) transporter
ES276_RS09950	COG1438	arginine binding
ES276_RS09955	COG0018	arginyl-trna synthetase
ES276_RS09970	COG0745	RESPONSE REGULATOR receiver
ES276_RS09975	COG5002	protein histidine kinase activity
ES276_RS09980	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ES276_RS09985	COG0573	inorganic phosphate transmembrane transporter activity
ES276_RS09995	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES276_RS10000	COG0704	Plays a role in the regulation of phosphate uptake
ES276_RS10020	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ES276_RS10040	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ES276_RS10055	COG0697	spore germination
ES276_RS10060	COG4499	WXG100 protein secretion system (Wss), protein YukC
ES276_RS10060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES276_RS10070	COG2217	Heavy metal translocating P-type atpase
ES276_RS10080	COG2226	methyltransferase
ES276_RS10095	COG0058	SHG alpha-glucan phosphorylase activity
ES276_RS10100	COG1640	4-alpha-glucanotransferase
ES276_RS10105	COG2182	Extracellular solute-binding protein
ES276_RS10110	COG1175	transmembrane transport
ES276_RS10115	COG3833	ABC-type maltose transport systems, permease component
ES276_RS10120	COG5521	maltodextrose utilization protein MalA
ES276_RS10125	COG1609	Transcriptional regulator
ES276_RS10135	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES276_RS10140	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ES276_RS10170	COG1476	TRANSCRIPTIONal
ES276_RS10185	COG0124	histidyl-tRNA synthetase
ES276_RS10200	COG2151	metal-sulfur cluster biosynthetic enzyme
ES276_RS10225	COG3959	Transketolase, thiamine diphosphate binding domain
ES276_RS10240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES276_RS10260	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ES276_RS10300	COG0383	alpha-mannosidase activity
ES276_RS10310	COG3537	Alpha-1,2-mannosidase
ES276_RS10330	COG0549	Belongs to the carbamate kinase family
ES276_RS10335	COG1288	antiporter activity
ES276_RS10340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES276_RS10350	COG3064	Membrane
ES276_RS10350	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ES276_RS10350	COG3583	domain protein
ES276_RS10365	COG1454	alcohol dehydrogenase
ES276_RS10370	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
ES276_RS10385	COG3716	PTS system mannose fructose sorbose family IID component
ES276_RS10395	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES276_RS10415	COG1070	Carbohydrate kinase
ES276_RS10425	COG0803	Belongs to the bacterial solute-binding protein 9 family
ES276_RS10425	COG3443	Belongs to the bacterial solute-binding protein 9 family
ES276_RS10430	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES276_RS10435	COG1121	(ABC) transporter
ES276_RS10440	COG1846	Transcriptional regulator
ES276_RS10445	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ES276_RS10455	COG1696	Membrane protein involved in D-alanine export
ES276_RS10470	COG2211	Major facilitator Superfamily
ES276_RS10490	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ES276_RS10495	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ES276_RS10515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ES276_RS10525	COG1755	Isoprenylcysteine carboxyl methyltransferase
ES276_RS10530	COG5002	protein histidine kinase activity
ES276_RS10535	COG0745	RESPONSE REGULATOR receiver
ES276_RS10540	COG0542	response to heat
ES276_RS10545	COG4463	regulation of RNA biosynthetic process
ES276_RS10550	COG1116	anion transmembrane transporter activity
ES276_RS10555	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ES276_RS10560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ES276_RS10580	COG0305	Participates in initiation and elongation during chromosome replication
ES276_RS10600	COG1040	competence protein
ES276_RS10605	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ES276_RS10610	COG1739	Uncharacterized protein family UPF0029
ES276_RS10640	COG0052	Belongs to the universal ribosomal protein uS2 family
ES276_RS10645	COG3942	CHAP domain
ES276_RS10655	COG1792	Involved in formation and maintenance of cell shape
ES276_RS10660	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ES276_RS10665	COG1122	ATPase activity
ES276_RS10670	COG1122	ATPase activity
ES276_RS10675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ES276_RS10685	COG0612	Peptidase, M16
ES276_RS10690	COG0612	Peptidase, M16
ES276_RS10695	COG2501	S4 domain
ES276_RS10705	COG0516	GMP reductase activity
ES276_RS10705	COG0517	IMP dehydrogenase activity
ES276_RS10710	COG0180	Tryptophanyl-tRNA synthetase
ES276_RS10715	COG0488	(ABC) transporter
ES276_RS10775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES276_RS10780	COG1475	DNA binding